TRBVB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of B cell differentiation (GO:0045579)5.95398257
2positive regulation of gamma-delta T cell activation (GO:0046645)5.43890284
3positive regulation of granulocyte differentiation (GO:0030854)5.07177209
4regulation of B cell differentiation (GO:0045577)4.99909647
5negative regulation of erythrocyte differentiation (GO:0045647)4.89755677
6negative regulation of T-helper cell differentiation (GO:0045623)4.78882204
7negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.78882204
8seminiferous tubule development (GO:0072520)4.66565028
9regulation of T-helper 1 cell differentiation (GO:0045625)4.59572166
10regulation of female gonad development (GO:2000194)4.49076561
11mucosal-associated lymphoid tissue development (GO:0048537)4.48221009
12Peyers patch development (GO:0048541)4.48221009
13definitive hemopoiesis (GO:0060216)4.42876579
14negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.33423071
15B cell receptor signaling pathway (GO:0050853)4.11690483
16mature B cell differentiation involved in immune response (GO:0002313)4.09209260
17cellular response to exogenous dsRNA (GO:0071360)4.02051295
18negative regulation of granulocyte differentiation (GO:0030853)3.93573511
19regulation of granulocyte differentiation (GO:0030852)3.75971423
20dosage compensation (GO:0007549)3.74992424
21regulation of B cell apoptotic process (GO:0002902)3.64687134
22negative regulation of B cell apoptotic process (GO:0002903)3.60968720
23regulation of gamma-delta T cell activation (GO:0046643)3.55627649
24mast cell degranulation (GO:0043303)3.53914505
25mast cell activation involved in immune response (GO:0002279)3.53914505
26poly(A)+ mRNA export from nucleus (GO:0016973)3.53013220
27regulation of B cell receptor signaling pathway (GO:0050855)3.53008795
28regulation of gamma-delta T cell differentiation (GO:0045586)3.49816282
29regulation of germinal center formation (GO:0002634)3.47735144
30regulation of dendritic cell antigen processing and presentation (GO:0002604)3.44003002
31positive thymic T cell selection (GO:0045059)3.42028694
32mast cell activation (GO:0045576)3.33980604
33immunoglobulin mediated immune response (GO:0016064)3.32429929
34negative thymic T cell selection (GO:0045060)3.29267546
35hepatocyte apoptotic process (GO:0097284)3.26275768
36lymphoid progenitor cell differentiation (GO:0002320)3.24559343
37mature B cell differentiation (GO:0002335)3.24203785
38autophagic vacuole fusion (GO:0000046)3.24166219
39cellular hyperosmotic response (GO:0071474)3.20009693
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19958137
41response to peptidoglycan (GO:0032494)3.19748559
42G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.19503399
43negative regulation of alpha-beta T cell differentiation (GO:0046639)3.11860693
44purine nucleotide salvage (GO:0032261)3.11442004
45purinergic nucleotide receptor signaling pathway (GO:0035590)3.08918258
46nucleotide salvage (GO:0043173)3.05691892
47negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.01234762
48organelle membrane fusion (GO:0090174)3.00986143
49CD4-positive, alpha-beta T cell activation (GO:0035710)3.00703621
50response to hydroperoxide (GO:0033194)3.00300637
51L-fucose catabolic process (GO:0042355)3.00210205
52fucose catabolic process (GO:0019317)3.00210205
53L-fucose metabolic process (GO:0042354)3.00210205
54negative regulation of interleukin-17 production (GO:0032700)2.99445345
55negative T cell selection (GO:0043383)2.98677383
56B cell mediated immunity (GO:0019724)2.98609439
57histamine secretion (GO:0001821)2.95049643
58regulation of interleukin-17 production (GO:0032660)2.94128892
59interkinetic nuclear migration (GO:0022027)2.88232439
60alpha-beta T cell activation (GO:0046631)2.87682044
61positive regulation of B cell activation (GO:0050871)2.87608292
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87587452
63response to host immune response (GO:0052572)2.87587452
64pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.87113821
65purine deoxyribonucleotide catabolic process (GO:0009155)2.86452841
66response to muramyl dipeptide (GO:0032495)2.85901721
67positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.83303023
68pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.83160423
69regulation of antigen processing and presentation (GO:0002577)2.77428214
70cellular response to dsRNA (GO:0071359)2.76118736
71regulation of chromatin silencing (GO:0031935)2.74867028
72regulation of B cell activation (GO:0050864)2.74096978
73regulation of T-helper 2 cell differentiation (GO:0045628)2.73652417
74positive regulation of antigen processing and presentation (GO:0002579)2.73516157
75negative regulation of interleukin-12 production (GO:0032695)2.72481731
76ribosomal small subunit assembly (GO:0000028)2.72401890
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72190680
78B cell differentiation (GO:0030183)2.71512712
79positive T cell selection (GO:0043368)2.70684920
80CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.68009708
81positive regulation of natural killer cell differentiation (GO:0032825)2.66866275
82viral transcription (GO:0019083)2.66632429
83megakaryocyte development (GO:0035855)2.66239320
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65925163
85regulation of histone phosphorylation (GO:0033127)2.64679402
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64477941
87response to host (GO:0075136)2.64477941
88response to host defenses (GO:0052200)2.64477941
89cellular extravasation (GO:0045123)2.64365669
90positive regulation of isotype switching (GO:0045830)2.64078605
91positive regulation of interleukin-17 production (GO:0032740)2.62139648
92regulation of erythrocyte differentiation (GO:0045646)2.62063791
93antigen processing and presentation of endogenous antigen (GO:0019883)2.60915828
94positive regulation of T-helper cell differentiation (GO:0045624)2.60723369
95neutrophil activation involved in immune response (GO:0002283)2.58757706
96negative regulation of T cell mediated immunity (GO:0002710)2.58201688
97B cell activation (GO:0042113)2.58193082
98histone H3-K9 modification (GO:0061647)2.56014283
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55292699
100pinocytosis (GO:0006907)2.55187065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.29167620
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.57927086
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.09913504
4SCL_19346495_ChIP-Seq_HPC-7_Human3.83707243
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.38479441
6VDR_21846776_ChIP-Seq_THP-1_Human3.35703421
7VDR_24763502_ChIP-Seq_THP-1_Human3.29050192
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98321292
9MYB_26560356_Chip-Seq_TH2_Human2.94386412
10E2F7_22180533_ChIP-Seq_HELA_Human2.88347671
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79072978
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67760081
13SPI1_23547873_ChIP-Seq_NB4_Human2.67531909
14MYC_22102868_ChIP-Seq_BL_Human2.63197509
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54622946
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53010545
17UTX_26944678_Chip-Seq_JUKART_Human2.35597287
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34048673
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29132578
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29111098
21MYB_26560356_Chip-Seq_TH1_Human2.28011493
22RUNX_20019798_ChIP-Seq_JUKART_Human2.27557286
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27190013
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24731911
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.22697996
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14173331
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09887135
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09801873
29GATA3_27048872_Chip-Seq_THYMUS_Human2.00308870
30MAF_26560356_Chip-Seq_TH1_Human1.97123949
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95275764
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89523302
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84588727
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.84234917
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.83633990
36VDR_24787735_ChIP-Seq_THP-1_Human1.82306964
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82275205
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81088081
39FOXP3_21729870_ChIP-Seq_TREG_Human1.80550132
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77295082
41VDR_23849224_ChIP-Seq_CD4+_Human1.73093984
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.72892404
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70719482
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.70465801
45CIITA_25753668_ChIP-Seq_RAJI_Human1.67807531
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.64106329
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62063260
48SPI1_23127762_ChIP-Seq_K562_Human1.60591519
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.60158535
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56269204
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55928365
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52846887
53GATA3_26560356_Chip-Seq_TH2_Human1.51482983
54MAF_26560356_Chip-Seq_TH2_Human1.50334896
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49583359
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47643852
57ZNF274_21170338_ChIP-Seq_K562_Hela1.45669143
58GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.44918163
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42999983
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42871041
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41565674
62TCF7_22412390_ChIP-Seq_EML_Mouse1.39419808
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30472241
64KDM2B_26808549_Chip-Seq_DND41_Human1.30403971
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29558348
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27832248
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25856068
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22969988
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.21607432
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21565930
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21194867
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18078853
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15749182
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15541383
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13117580
76RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12053401
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10989218
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.10846856
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08104710
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.07032835
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00836816
82KDM5A_27292631_Chip-Seq_BREAST_Human1.00361745
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99621465
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99199139
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96682449
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96600976
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95985473
88ETS1_20019798_ChIP-Seq_JURKAT_Human0.95050616
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95024959
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94781832
91ELK1_19687146_ChIP-ChIP_HELA_Human0.93636289
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90531411
93ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90394484
94PU_27001747_Chip-Seq_BMDM_Mouse0.89908297
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88728155
96ELF5_23300383_ChIP-Seq_T47D_Human0.88663077
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.88471956
98GATA1_19941826_ChIP-Seq_K562_Human0.87724513
99MYC_18555785_ChIP-Seq_MESCs_Mouse0.85430226
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83833185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.71063362
2MP0009278_abnormal_bone_marrow3.95037746
3MP0001835_abnormal_antigen_presentation3.78508759
4MP0005397_hematopoietic_system_phenotyp2.91059141
5MP0001545_abnormal_hematopoietic_system2.91059141
6MP0008057_abnormal_DNA_replication2.82566419
7MP0003436_decreased_susceptibility_to2.80983502
8MP0002148_abnormal_hypersensitivity_rea2.47587536
9MP0005464_abnormal_platelet_physiology2.44747994
10MP0005084_abnormal_gallbladder_morpholo2.32998938
11MP0001800_abnormal_humoral_immune2.28552040
12MP0004808_abnormal_hematopoietic_stem2.28261942
13MP0003763_abnormal_thymus_physiology2.23806017
14MP0006054_spinal_hemorrhage2.14949209
15MP0002420_abnormal_adaptive_immunity2.14399228
16MP0002398_abnormal_bone_marrow2.11036627
17MP0001819_abnormal_immune_cell2.10581210
18MP0005000_abnormal_immune_tolerance2.10363500
19MP0000685_abnormal_immune_system2.09314069
20MP0001790_abnormal_immune_system2.06112323
21MP0005387_immune_system_phenotype2.06112323
22MP0003183_abnormal_peptide_metabolism2.03616087
23MP0001853_heart_inflammation2.01899464
24MP0008007_abnormal_cellular_replicative2.01841009
25MP0003172_abnormal_lysosome_physiology1.98991965
26MP0002723_abnormal_immune_serum1.98279744
27MP0002419_abnormal_innate_immunity1.94445231
28MP0002452_abnormal_antigen_presenting1.93355173
29MP0002009_preneoplasia1.87934802
30MP0000716_abnormal_immune_system1.81541090
31MP0005025_abnormal_response_to1.79886764
32MP0000689_abnormal_spleen_morphology1.73089092
33MP0005075_abnormal_melanosome_morpholog1.72815234
34MP0002722_abnormal_immune_system1.69604944
35MP0002405_respiratory_system_inflammati1.67857808
36MP0009785_altered_susceptibility_to1.67301258
37MP0008058_abnormal_DNA_repair1.58327377
38MP0002429_abnormal_blood_cell1.57787662
39MP0001986_abnormal_taste_sensitivity1.54989431
40MP0003303_peritoneal_inflammation1.53259227
41MP0005671_abnormal_response_to1.52769771
42MP0003787_abnormal_imprinting1.50209801
43MP0000465_gastrointestinal_hemorrhage1.48652232
44MP0000703_abnormal_thymus_morphology1.47497643
45MP0002166_altered_tumor_susceptibility1.46078306
46MP0001873_stomach_inflammation1.42962278
47MP0003866_abnormal_defecation1.41842821
48MP0002822_catalepsy1.37362444
49MP0006292_abnormal_olfactory_placode1.33820757
50MP0000681_abnormal_thyroid_gland1.32054631
51MP0010155_abnormal_intestine_physiology1.28809136
52MP0005220_abnormal_exocrine_pancreas1.28275393
53MP0009764_decreased_sensitivity_to1.27268257
54MP0010094_abnormal_chromosome_stability1.24711924
55MP0002006_tumorigenesis1.24499931
56MP0003806_abnormal_nucleotide_metabolis1.20380029
57MP0003828_pulmonary_edema1.14619287
58MP0009840_abnormal_foam_cell1.14100267
59MP0003786_premature_aging1.12477909
60MP0008877_abnormal_DNA_methylation1.11451006
61MP0002019_abnormal_tumor_incidence1.07450214
62MP0004947_skin_inflammation1.01803720
63MP0001845_abnormal_inflammatory_respons1.01078431
64MP0008469_abnormal_protein_level1.01077795
65MP0003943_abnormal_hepatobiliary_system1.00466663
66MP0009765_abnormal_xenobiotic_induced1.00455984
67MP0003300_gastrointestinal_ulcer0.94010019
68MP0003724_increased_susceptibility_to0.92785107
69MP0005174_abnormal_tail_pigmentation0.91476744
70MP0001533_abnormal_skeleton_physiology0.91459591
71MP0003252_abnormal_bile_duct0.90467242
72MP0008995_early_reproductive_senescence0.89087906
73MP0008875_abnormal_xenobiotic_pharmacok0.88658678
74MP0009379_abnormal_foot_pigmentation0.88058669
75MP0004782_abnormal_surfactant_physiolog0.84157493
76MP0009697_abnormal_copulation0.82402901
77MP0005451_abnormal_body_composition0.81261147
78MP0005319_abnormal_enzyme/_coenzyme0.77647156
79MP0009115_abnormal_fat_cell0.70234942
80MP0003191_abnormal_cellular_cholesterol0.69863348
81MP0008961_abnormal_basal_metabolism0.69767452
82MP0004185_abnormal_adipocyte_glucose0.68962960
83MP0003656_abnormal_erythrocyte_physiolo0.67779597
84MP0000858_altered_metastatic_potential0.66171331
85MP0002876_abnormal_thyroid_physiology0.62929982
86MP0010352_gastrointestinal_tract_polyps0.60695899
87MP0002138_abnormal_hepatobiliary_system0.59279117
88MP0009763_increased_sensitivity_to0.59187919
89MP0000598_abnormal_liver_morphology0.58293228
90MP0005390_skeleton_phenotype0.57806067
91MP0002998_abnormal_bone_remodeling0.57508846
92MP0002083_premature_death0.55245966
93MP0000313_abnormal_cell_death0.55191692
94MP0001881_abnormal_mammary_gland0.54443975
95MP0005535_abnormal_body_temperature0.52834209
96MP0006036_abnormal_mitochondrial_physio0.52371597
97MP0010307_abnormal_tumor_latency0.51647397
98MP0000383_abnormal_hair_follicle0.51097338
99MP0005266_abnormal_metabolism0.49862552
100MP0008873_increased_physiological_sensi0.49498729

Predicted human phenotypes

RankGene SetZ-score
1Acute lymphatic leukemia (HP:0006721)6.75109563
2Agammaglobulinemia (HP:0004432)6.67104445
3Abnormality of B cell number (HP:0010975)6.63372127
4B lymphocytopenia (HP:0010976)6.42823299
5Panhypogammaglobulinemia (HP:0003139)6.20275730
6Acute myeloid leukemia (HP:0004808)5.62252666
7Elevated erythrocyte sedimentation rate (HP:0003565)4.83527605
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.16429367
9Myositis (HP:0100614)3.73931622
10Recurrent viral infections (HP:0004429)3.70292393
11Thrombocytosis (HP:0001894)3.56309499
12Meningitis (HP:0001287)3.51970795
13Spondylolisthesis (HP:0003302)3.50845368
14Viral hepatitis (HP:0006562)3.46615970
15Recurrent fungal infections (HP:0002841)3.33218951
16Cellulitis (HP:0100658)3.27537249
17Hypochromic microcytic anemia (HP:0004840)3.22056091
18Autoimmune hemolytic anemia (HP:0001890)3.21633138
19Polygenic inheritance (HP:0010982)3.17008686
20Encephalitis (HP:0002383)3.14979676
21Papilledema (HP:0001085)3.04178653
22Prolonged bleeding time (HP:0003010)3.02223095
23Abnormality of T cell physiology (HP:0011840)3.00017083
24Hypoplasia of the thymus (HP:0000778)2.97081582
25Gastrointestinal inflammation (HP:0004386)2.96290425
26Granulocytopenia (HP:0001913)2.94855465
27Colitis (HP:0002583)2.91618069
28Increased IgE level (HP:0003212)2.81802192
29Abnormality of the prostate (HP:0008775)2.74887411
30Stomatitis (HP:0010280)2.74262356
31Eosinophilia (HP:0001880)2.71351137
32Abnormality of T cells (HP:0002843)2.71025461
33Autoimmune thrombocytopenia (HP:0001973)2.70888584
34Chronic mucocutaneous candidiasis (HP:0002728)2.63910292
35Recurrent cutaneous fungal infections (HP:0011370)2.63910292
36Osteomyelitis (HP:0002754)2.61669682
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.59811868
38Metaphyseal dysplasia (HP:0100255)2.59428505
39Inflammation of the large intestine (HP:0002037)2.56862565
40Stomach cancer (HP:0012126)2.55456295
41Chronic otitis media (HP:0000389)2.54510894
42Severe combined immunodeficiency (HP:0004430)2.47931995
43Hypergammaglobulinemia (HP:0010702)2.42150573
44Thyroiditis (HP:0100646)2.38927311
45Microvesicular hepatic steatosis (HP:0001414)2.38714821
46Abnormality of eosinophils (HP:0001879)2.34175969
47Leukocytosis (HP:0001974)2.31747941
48Verrucae (HP:0200043)2.30057402
49Papilloma (HP:0012740)2.30057402
50Renal cortical cysts (HP:0000803)2.29487864
51Aplasia/Hypoplasia of the thymus (HP:0010515)2.22948807
52Thoracic kyphosis (HP:0002942)2.22562796
53Recurrent abscess formation (HP:0002722)2.22329636
54IgM deficiency (HP:0002850)2.19782792
55Alveolar cell carcinoma (HP:0006519)2.19560674
56Increased IgM level (HP:0003496)2.19544117
57Recurrent bacterial skin infections (HP:0005406)2.17330109
58Neoplasm of the tracheobronchial system (HP:0100552)2.15798016
59Epistaxis (HP:0000421)2.13307678
60Mediastinal lymphadenopathy (HP:0100721)2.11443049
61Myelodysplasia (HP:0002863)2.09897569
62Increased intramyocellular lipid droplets (HP:0012240)2.09468115
63Abnormal hemoglobin (HP:0011902)2.08356490
64Neutropenia (HP:0001875)2.05773072
65Fatigue (HP:0012378)2.04963659
66Hypochromic anemia (HP:0001931)2.04474745
67Thickened calvaria (HP:0002684)2.02492195
68Increased cerebral lipofuscin (HP:0011813)2.01393318
69Sepsis (HP:0100806)2.01361854
70Dysostosis multiplex (HP:0000943)1.97821377
71Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97071346
72Tubulointerstitial nephritis (HP:0001970)1.96176541
73Orchitis (HP:0100796)1.94778345
74Abnormality of T cell number (HP:0011839)1.93795000
75Interstitial pulmonary disease (HP:0006530)1.88878188
76Acute hepatic failure (HP:0006554)1.87050397
77T lymphocytopenia (HP:0005403)1.86808128
78Recurrent skin infections (HP:0001581)1.83681605
79Abnormality of male internal genitalia (HP:0000022)1.82391753
80Widely spaced teeth (HP:0000687)1.81748322
81Chronic obstructive pulmonary disease (HP:0006510)1.80912930
82Obstructive lung disease (HP:0006536)1.80912930
83Syringomyelia (HP:0003396)1.79571587
84Spinal cord lesions (HP:0100561)1.79571587
85Combined immunodeficiency (HP:0005387)1.79134950
86Pallor (HP:0000980)1.78871212
87Failure to thrive in infancy (HP:0001531)1.77835549
88Hepatitis (HP:0012115)1.77568826
89Chest pain (HP:0100749)1.76958428
90Increased muscle lipid content (HP:0009058)1.76303541
91Neurodegeneration (HP:0002180)1.72861687
92Decreased central vision (HP:0007663)1.72784273
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.72298722
94Vacuolated lymphocytes (HP:0001922)1.71430039
95Aplastic anemia (HP:0001915)1.70225664
96Recurrent lower respiratory tract infections (HP:0002783)1.69486733
97Abnormality of oral frenula (HP:0000190)1.69257022
98Vasculitis (HP:0002633)1.68925840
99Cutis marmorata (HP:0000965)1.67572047
100Skin rash (HP:0000988)1.67185423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT36.38947001
2KIT5.88173510
3MAP4K13.72579866
4SCYL23.20455999
5TXK2.60562404
6PIK3CG2.54162545
7FES2.29412603
8CSF1R2.25939802
9TEC2.23402554
10BMPR22.20940460
11BCKDK2.15482757
12PRPF4B2.04311704
13BTK1.95032288
14RIPK41.93691629
15SYK1.85591541
16TBK11.85245005
17NUAK11.68517082
18TNK21.56695775
19CDK61.56116318
20TAOK31.53920836
21MAP2K31.51078057
22TESK21.46372882
23EEF2K1.43033917
24ERN11.42883447
25ZAP701.42163296
26ITK1.33160212
27MATK1.31539098
28MAP3K141.30806211
29MKNK11.19533412
30IKBKE1.19316296
31RPS6KB21.15194300
32HCK1.12054581
33BRD41.10303832
34JAK31.09487336
35LYN1.01347440
36IKBKB1.00719455
37LCK0.99444432
38GRK60.98947756
39CCNB10.97521750
40MKNK20.93747850
41CDK120.92275885
42DAPK10.92046519
43HIPK20.91625408
44PIK3CA0.81927671
45BMPR1B0.79867312
46KDR0.72670662
47PIM10.72349537
48IRAK10.71646282
49PKN20.69395332
50VRK20.65438165
51EIF2AK30.65098656
52MAP3K110.64743572
53TRPM70.64089153
54MARK30.62237094
55CDK40.62163489
56MAPKAPK30.59901066
57LRRK20.57395627
58CHUK0.57183895
59JAK10.57085361
60CDK90.56705703
61MAP3K50.55856619
62IRAK40.54414340
63TGFBR10.52810990
64PRKCQ0.51294490
65ATR0.50652739
66MAPK30.50061529
67CDK80.49640796
68MAPK120.49406144
69PRKD20.47353874
70ABL10.42739784
71EIF2AK20.41517963
72DYRK1B0.38452814
73PASK0.35904044
74MAPK110.35201270
75RPS6KA40.32807419
76RPS6KL10.31032953
77RPS6KC10.31032953
78MAPK70.30971030
79MAPKAPK50.30584089
80TAOK20.29940327
81IGF1R0.28289138
82JAK20.28071799
83RPS6KA60.27638283
84MAPK10.25904977
85PBK0.25285943
86MAPKAPK20.25268721
87ACVR1B0.25162332
88MELK0.24827157
89STK390.24812028
90NME10.24762106
91TYK20.24307071
92SIK30.24223836
93TIE10.23965294
94AKT30.23735711
95IRAK30.23450978
96CDK70.23394264
97UHMK10.22974966
98DYRK30.22620507
99MAP3K70.21778680
100MAPK40.21635414

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.20915750
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.07364926
3Asthma_Homo sapiens_hsa053102.76858109
4Other glycan degradation_Homo sapiens_hsa005112.55389421
5Allograft rejection_Homo sapiens_hsa053302.43117030
6Leishmaniasis_Homo sapiens_hsa051402.35660671
7Base excision repair_Homo sapiens_hsa034102.24221839
8Acute myeloid leukemia_Homo sapiens_hsa052212.15458696
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13845572
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06822753
11Graft-versus-host disease_Homo sapiens_hsa053322.04156650
12Autoimmune thyroid disease_Homo sapiens_hsa053202.00718229
13DNA replication_Homo sapiens_hsa030301.94399831
14B cell receptor signaling pathway_Homo sapiens_hsa046621.92874512
15Homologous recombination_Homo sapiens_hsa034401.91671187
16Non-homologous end-joining_Homo sapiens_hsa034501.88479538
17Ribosome_Homo sapiens_hsa030101.88439857
18Type I diabetes mellitus_Homo sapiens_hsa049401.87822255
19Hematopoietic cell lineage_Homo sapiens_hsa046401.86538792
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83174423
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.72598265
22Platelet activation_Homo sapiens_hsa046111.57914471
23Antigen processing and presentation_Homo sapiens_hsa046121.50879113
24Herpes simplex infection_Homo sapiens_hsa051681.48915485
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41557214
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41482702
27Fanconi anemia pathway_Homo sapiens_hsa034601.40979779
28African trypanosomiasis_Homo sapiens_hsa051431.39775220
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39716889
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.36948727
31Tuberculosis_Homo sapiens_hsa051521.25647156
32Osteoclast differentiation_Homo sapiens_hsa043801.24783921
33Influenza A_Homo sapiens_hsa051641.22746721
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.17424235
35Mismatch repair_Homo sapiens_hsa034301.15318119
36Regulation of autophagy_Homo sapiens_hsa041401.13852262
37Toxoplasmosis_Homo sapiens_hsa051451.12663417
38Measles_Homo sapiens_hsa051621.10560954
39Rheumatoid arthritis_Homo sapiens_hsa053231.08282874
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06004083
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02886037
42Chronic myeloid leukemia_Homo sapiens_hsa052201.01833147
43Staphylococcus aureus infection_Homo sapiens_hsa051501.01790392
44Caffeine metabolism_Homo sapiens_hsa002321.01771687
45TNF signaling pathway_Homo sapiens_hsa046680.98490495
46Spliceosome_Homo sapiens_hsa030400.98172359
47Non-small cell lung cancer_Homo sapiens_hsa052230.96422695
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.96246806
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95976538
50Viral myocarditis_Homo sapiens_hsa054160.95148900
51Epstein-Barr virus infection_Homo sapiens_hsa051690.93619510
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91815497
53Nucleotide excision repair_Homo sapiens_hsa034200.91182901
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89663737
55Phototransduction_Homo sapiens_hsa047440.88827346
56Legionellosis_Homo sapiens_hsa051340.83404805
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83372479
58Pancreatic cancer_Homo sapiens_hsa052120.83343959
59Hepatitis B_Homo sapiens_hsa051610.83279903
60Systemic lupus erythematosus_Homo sapiens_hsa053220.82550077
61T cell receptor signaling pathway_Homo sapiens_hsa046600.82323259
62Pyrimidine metabolism_Homo sapiens_hsa002400.75861931
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74599419
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.73409757
65Viral carcinogenesis_Homo sapiens_hsa052030.73187919
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73070966
67Malaria_Homo sapiens_hsa051440.69895305
68Shigellosis_Homo sapiens_hsa051310.67801259
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67288506
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66377772
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63182067
72Purine metabolism_Homo sapiens_hsa002300.62033055
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61597304
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61421187
75Dorso-ventral axis formation_Homo sapiens_hsa043200.59192791
76One carbon pool by folate_Homo sapiens_hsa006700.59123958
77RNA degradation_Homo sapiens_hsa030180.58843008
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58168616
79Peroxisome_Homo sapiens_hsa041460.54583503
80mRNA surveillance pathway_Homo sapiens_hsa030150.54515969
81Hepatitis C_Homo sapiens_hsa051600.54109640
82RNA polymerase_Homo sapiens_hsa030200.53432779
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50264964
84HTLV-I infection_Homo sapiens_hsa051660.50080431
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48761247
86Lysine degradation_Homo sapiens_hsa003100.48419355
87mTOR signaling pathway_Homo sapiens_hsa041500.46956569
88Inositol phosphate metabolism_Homo sapiens_hsa005620.46177425
89Chemokine signaling pathway_Homo sapiens_hsa040620.45873295
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.43201819
91Insulin resistance_Homo sapiens_hsa049310.40848908
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.39532092
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.38768666
94RNA transport_Homo sapiens_hsa030130.38353500
95Pertussis_Homo sapiens_hsa051330.36036855
96Prolactin signaling pathway_Homo sapiens_hsa049170.33292530
97VEGF signaling pathway_Homo sapiens_hsa043700.32155596
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.30027761
99Apoptosis_Homo sapiens_hsa042100.28894122
100p53 signaling pathway_Homo sapiens_hsa041150.28671488

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