

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 9.60324579 |
| 2 | negative regulation of cell killing (GO:0031342) | 9.31979784 |
| 3 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 9.31979784 |
| 4 | negative T cell selection (GO:0043383) | 8.81973821 |
| 5 | positive T cell selection (GO:0043368) | 8.40882735 |
| 6 | regulation of gamma-delta T cell differentiation (GO:0045586) | 8.39592579 |
| 7 | interferon-gamma production (GO:0032609) | 8.34155594 |
| 8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 7.81713363 |
| 9 | positive thymic T cell selection (GO:0045059) | 7.72841382 |
| 10 | negative thymic T cell selection (GO:0045060) | 7.62969506 |
| 11 | regulation of gamma-delta T cell activation (GO:0046643) | 7.62469540 |
| 12 | activated T cell proliferation (GO:0050798) | 6.65536990 |
| 13 | thymic T cell selection (GO:0045061) | 6.64984785 |
| 14 | T cell selection (GO:0045058) | 6.54108317 |
| 15 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.29776238 |
| 16 | T cell migration (GO:0072678) | 6.06034915 |
| 17 | response to interleukin-15 (GO:0070672) | 6.04426173 |
| 18 | T cell receptor signaling pathway (GO:0050852) | 5.96520335 |
| 19 | cellular response to interleukin-15 (GO:0071350) | 5.93991657 |
| 20 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.74433613 |
| 21 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.74433613 |
| 22 | regulation of memory T cell differentiation (GO:0043380) | 5.62998194 |
| 23 | regulation of activation of Janus kinase activity (GO:0010533) | 5.57523718 |
| 24 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.36641320 |
| 25 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 5.01880656 |
| 26 | T cell costimulation (GO:0031295) | 5.01595075 |
| 27 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.97561933 |
| 28 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.97561933 |
| 29 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.93176484 |
| 30 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.93176484 |
| 31 | regulation of T cell mediated cytotoxicity (GO:0001914) | 4.93079858 |
| 32 | lymphocyte costimulation (GO:0031294) | 4.91520032 |
| 33 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 4.90985605 |
| 34 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.90710353 |
| 35 | regulation of T cell tolerance induction (GO:0002664) | 4.90338261 |
| 36 | leukocyte aggregation (GO:0070486) | 4.87911688 |
| 37 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.74651266 |
| 38 | tolerance induction (GO:0002507) | 4.74478851 |
| 39 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.72556268 |
| 40 | negative regulation of T cell mediated immunity (GO:0002710) | 4.66050780 |
| 41 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.64547303 |
| 42 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.59801615 |
| 43 | V(D)J recombination (GO:0033151) | 4.54470936 |
| 44 | positive regulation of isotype switching (GO:0045830) | 4.48896341 |
| 45 | mast cell activation (GO:0045576) | 4.41228323 |
| 46 | sleep (GO:0030431) | 4.37210393 |
| 47 | positive regulation of interleukin-17 production (GO:0032740) | 4.33659144 |
| 48 | T cell differentiation (GO:0030217) | 4.33092230 |
| 49 | positive regulation of defense response to virus by host (GO:0002230) | 4.23393383 |
| 50 | alpha-beta T cell activation (GO:0046631) | 4.11697770 |
| 51 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.10679631 |
| 52 | heterotypic cell-cell adhesion (GO:0034113) | 4.07972840 |
| 53 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.07949330 |
| 54 | alpha-beta T cell differentiation (GO:0046632) | 4.05800242 |
| 55 | response to muramyl dipeptide (GO:0032495) | 3.99312672 |
| 56 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.98694436 |
| 57 | regulation of response to tumor cell (GO:0002834) | 3.96805012 |
| 58 | positive regulation of response to tumor cell (GO:0002836) | 3.96805012 |
| 59 | positive regulation of immune response to tumor cell (GO:0002839) | 3.96805012 |
| 60 | regulation of immune response to tumor cell (GO:0002837) | 3.96805012 |
| 61 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.96757492 |
| 62 | positive regulation of DNA recombination (GO:0045911) | 3.94537792 |
| 63 | positive regulation of B cell mediated immunity (GO:0002714) | 3.92708730 |
| 64 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.92708730 |
| 65 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.92546690 |
| 66 | positive regulation of interleukin-2 production (GO:0032743) | 3.91690034 |
| 67 | positive regulation of tolerance induction (GO:0002645) | 3.88918298 |
| 68 | leukocyte cell-cell adhesion (GO:0007159) | 3.85778899 |
| 69 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.84091844 |
| 70 | positive regulation of cell killing (GO:0031343) | 3.80341927 |
| 71 | positive regulation of T cell mediated immunity (GO:0002711) | 3.78893338 |
| 72 | T cell activation (GO:0042110) | 3.78760795 |
| 73 | regulation of cell killing (GO:0031341) | 3.72327960 |
| 74 | positive regulation of T-helper 1 type immune response (GO:0002827) | 3.66766514 |
| 75 | regulation of isotype switching (GO:0045191) | 3.66261538 |
| 76 | positive regulation of humoral immune response (GO:0002922) | 3.66179458 |
| 77 | mast cell activation involved in immune response (GO:0002279) | 3.58635100 |
| 78 | mast cell degranulation (GO:0043303) | 3.58635100 |
| 79 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.58019692 |
| 80 | negative regulation of innate immune response (GO:0045824) | 3.54083004 |
| 81 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.53191043 |
| 82 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.52985878 |
| 83 | T cell proliferation (GO:0042098) | 3.52146327 |
| 84 | regulation of regulatory T cell differentiation (GO:0045589) | 3.52116716 |
| 85 | regulation of T-helper 1 type immune response (GO:0002825) | 3.51743728 |
| 86 | regulation of T cell mediated immunity (GO:0002709) | 3.50239294 |
| 87 | regulation of B cell differentiation (GO:0045577) | 3.49804916 |
| 88 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.47117668 |
| 89 | cytidine deamination (GO:0009972) | 3.46885832 |
| 90 | cytidine metabolic process (GO:0046087) | 3.46885832 |
| 91 | cytidine catabolic process (GO:0006216) | 3.46885832 |
| 92 | negative regulation of interleukin-10 production (GO:0032693) | 3.45613285 |
| 93 | natural killer cell activation (GO:0030101) | 3.45190630 |
| 94 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.45066423 |
| 95 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.44605616 |
| 96 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.43821896 |
| 97 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.43685174 |
| 98 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.43415566 |
| 99 | regulation of tolerance induction (GO:0002643) | 3.43228322 |
| 100 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.41689810 |
| 101 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.38975282 |
| 102 | regulation of defense response to virus by host (GO:0050691) | 3.37761370 |
| 103 | lymphocyte migration (GO:0072676) | 3.36599034 |
| 104 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.33497996 |
| 105 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.33313288 |
| 106 | regulation of response to interferon-gamma (GO:0060330) | 3.32821097 |
| 107 | negative regulation of T cell apoptotic process (GO:0070233) | 3.32316554 |
| 108 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.31145989 |
| 109 | regulation of B cell mediated immunity (GO:0002712) | 3.29263706 |
| 110 | leukocyte degranulation (GO:0043299) | 3.28374461 |
| 111 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 3.27106936 |
| 112 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.22768952 |
| 113 | dendritic cell chemotaxis (GO:0002407) | 3.22430987 |
| 114 | neutrophil activation (GO:0042119) | 3.22337558 |
| 115 | cellular defense response (GO:0006968) | 3.21944048 |
| 116 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.21223011 |
| 117 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.20774044 |
| 118 | B cell receptor signaling pathway (GO:0050853) | 3.20055246 |
| 119 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.19892308 |
| 120 | natural killer cell differentiation (GO:0001779) | 3.17034211 |
| 121 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.16448693 |
| 122 | positive regulation of T cell cytokine production (GO:0002726) | 3.14554554 |
| 123 | T cell differentiation involved in immune response (GO:0002292) | 3.14159427 |
| 124 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.14159427 |
| 125 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.14159427 |
| 126 | regulation of interleukin-17 production (GO:0032660) | 3.13940825 |
| 127 | T cell homeostasis (GO:0043029) | 3.13644305 |
| 128 | positive regulation of T cell activation (GO:0050870) | 3.11072449 |
| 129 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.08483621 |
| 130 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.08483621 |
| 131 | leukocyte tethering or rolling (GO:0050901) | 3.08006080 |
| 132 | positive regulation of granulocyte differentiation (GO:0030854) | 3.07406572 |
| 133 | DNA deamination (GO:0045006) | 3.05876884 |
| 134 | regulation of germinal center formation (GO:0002634) | 3.04756373 |
| 135 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.04503112 |
| 136 | regulation of interleukin-2 production (GO:0032663) | 3.02820952 |
| 137 | lymphocyte differentiation (GO:0030098) | 3.02299247 |
| 138 | regulation of lymphocyte mediated immunity (GO:0002706) | 3.01471193 |
| 139 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.01203150 |
| 140 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.00818152 |
| 141 | regulation of defense response to virus by virus (GO:0050690) | 3.00708037 |
| 142 | regulation of alpha-beta T cell activation (GO:0046634) | 3.00678771 |
| 143 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.00249956 |
| 144 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.00198908 |
| 145 | T-helper cell differentiation (GO:0042093) | 3.00198908 |
| 146 | positive regulation of immunoglobulin production (GO:0002639) | 3.00075239 |
| 147 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.97891068 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.23193254 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.75109513 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.93303037 |
| 4 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.29876936 |
| 5 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 4.03105248 |
| 6 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.94319797 |
| 7 | MYC_22102868_ChIP-Seq_BL_Human | 3.71632492 |
| 8 | MYB_26560356_Chip-Seq_TH2_Human | 3.64769757 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.36958641 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.34599043 |
| 11 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.20511983 |
| 12 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.14979309 |
| 13 | MAF_26560356_Chip-Seq_TH1_Human | 3.10072702 |
| 14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.08902463 |
| 15 | UTX_26944678_Chip-Seq_JUKART_Human | 2.99877442 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.97515772 |
| 17 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.87824315 |
| 18 | MYB_26560356_Chip-Seq_TH1_Human | 2.87344517 |
| 19 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.46258585 |
| 20 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.38732084 |
| 21 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.37354911 |
| 22 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.34234176 |
| 23 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.20649081 |
| 24 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.16676779 |
| 25 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.12902667 |
| 26 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.12893763 |
| 27 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.09516327 |
| 28 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.05338316 |
| 29 | MAF_26560356_Chip-Seq_TH2_Human | 1.99580954 |
| 30 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.96288409 |
| 31 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.95060452 |
| 32 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.94342262 |
| 33 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.91132601 |
| 34 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.89977652 |
| 35 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.89113597 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.88763755 |
| 37 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.84989089 |
| 38 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.78482543 |
| 39 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.78169254 |
| 40 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.77922300 |
| 41 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.75209137 |
| 42 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.72205799 |
| 43 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.67984994 |
| 44 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.66434664 |
| 45 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61522913 |
| 46 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.60060551 |
| 47 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.57243134 |
| 48 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.50802653 |
| 49 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.43783146 |
| 50 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.42346151 |
| 51 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.38028348 |
| 52 | SPI1_23127762_ChIP-Seq_K562_Human | 1.37797723 |
| 53 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.37222793 |
| 54 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35747558 |
| 55 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.30355515 |
| 56 | GATA3_26560356_Chip-Seq_TH2_Human | 1.26014038 |
| 57 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.23700319 |
| 58 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.23464438 |
| 59 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.20444156 |
| 60 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.20236205 |
| 61 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.14947861 |
| 62 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.14882504 |
| 63 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.13303970 |
| 64 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.11740099 |
| 65 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.11243564 |
| 66 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08363038 |
| 67 | GATA3_26560356_Chip-Seq_TH1_Human | 1.06234882 |
| 68 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.05849651 |
| 69 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.04770443 |
| 70 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.04665034 |
| 71 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.03307335 |
| 72 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.02728264 |
| 73 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.01861793 |
| 74 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.01754984 |
| 75 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.00955082 |
| 76 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.98875735 |
| 77 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95296987 |
| 78 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94744273 |
| 79 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.93646654 |
| 80 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.93626022 |
| 81 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.93586440 |
| 82 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93346739 |
| 83 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.90557856 |
| 84 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.90073513 |
| 85 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.89367818 |
| 86 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82319477 |
| 87 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.82279566 |
| 88 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.82278196 |
| 89 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.81672142 |
| 90 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.81433440 |
| 91 | P300_27268052_Chip-Seq_Bcells_Human | 0.80970200 |
| 92 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80596788 |
| 93 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.79987980 |
| 94 | GATA2_19941826_ChIP-Seq_K562_Human | 0.79849293 |
| 95 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.79369435 |
| 96 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.79253913 |
| 97 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78750173 |
| 98 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.77854349 |
| 99 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.77646061 |
| 100 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.77054354 |
| 101 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.76399964 |
| 102 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.76199825 |
| 103 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.75949013 |
| 104 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.75781737 |
| 105 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.74990430 |
| 106 | GATA1_22025678_ChIP-Seq_K562_Human | 0.74854332 |
| 107 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.74339791 |
| 108 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.73580110 |
| 109 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.73004456 |
| 110 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.71907849 |
| 111 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.69883290 |
| 112 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.69740396 |
| 113 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.67480374 |
| 114 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.65658287 |
| 115 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.63095307 |
| 116 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.61592609 |
| 117 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.61391464 |
| 118 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.61129900 |
| 119 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.59975850 |
| 120 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.58133832 |
| 121 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.57540583 |
| 122 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.56498070 |
| 123 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.54690928 |
| 124 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.54494845 |
| 125 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.54033823 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.28808962 |
| 2 | MP0005671_abnormal_response_to | 4.79011301 |
| 3 | MP0000685_abnormal_immune_system | 3.38197833 |
| 4 | MP0000703_abnormal_thymus_morphology | 3.34582621 |
| 5 | MP0002398_abnormal_bone_marrow | 3.13246381 |
| 6 | MP0001800_abnormal_humoral_immune | 3.09766375 |
| 7 | MP0002420_abnormal_adaptive_immunity | 3.00782555 |
| 8 | MP0001819_abnormal_immune_cell | 2.96516420 |
| 9 | MP0002166_altered_tumor_susceptibility | 2.87879878 |
| 10 | MP0009333_abnormal_splenocyte_physiolog | 2.85756481 |
| 11 | MP0002723_abnormal_immune_serum | 2.79883183 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.78703160 |
| 13 | MP0001835_abnormal_antigen_presentation | 2.73957765 |
| 14 | MP0000716_abnormal_immune_system | 2.65973463 |
| 15 | MP0005387_immune_system_phenotype | 2.65207059 |
| 16 | MP0001790_abnormal_immune_system | 2.65207059 |
| 17 | MP0002006_tumorigenesis | 2.64971596 |
| 18 | MP0002722_abnormal_immune_system | 2.61709098 |
| 19 | MP0009785_altered_susceptibility_to | 2.55510236 |
| 20 | MP0002452_abnormal_antigen_presenting | 2.54619820 |
| 21 | MP0002405_respiratory_system_inflammati | 2.42248957 |
| 22 | MP0005025_abnormal_response_to | 2.38969615 |
| 23 | MP0001873_stomach_inflammation | 2.35065025 |
| 24 | MP0000689_abnormal_spleen_morphology | 2.30159909 |
| 25 | MP0002933_joint_inflammation | 2.26691775 |
| 26 | MP0006082_CNS_inflammation | 2.26038498 |
| 27 | MP0010155_abnormal_intestine_physiology | 2.21364618 |
| 28 | MP0004947_skin_inflammation | 2.20728009 |
| 29 | MP0000858_altered_metastatic_potential | 2.15625495 |
| 30 | MP0002429_abnormal_blood_cell | 2.15008572 |
| 31 | MP0003436_decreased_susceptibility_to | 2.11490853 |
| 32 | MP0002396_abnormal_hematopoietic_system | 2.09339898 |
| 33 | MP0003866_abnormal_defecation | 2.03128805 |
| 34 | MP0002148_abnormal_hypersensitivity_rea | 1.99896182 |
| 35 | MP0005464_abnormal_platelet_physiology | 1.96758204 |
| 36 | MP0002419_abnormal_innate_immunity | 1.89539803 |
| 37 | MP0004381_abnormal_hair_follicle | 1.86304885 |
| 38 | MP0003300_gastrointestinal_ulcer | 1.85594054 |
| 39 | MP0002132_abnormal_respiratory_system | 1.83720103 |
| 40 | MP0003724_increased_susceptibility_to | 1.80051228 |
| 41 | MP0003195_calcinosis | 1.75669135 |
| 42 | MP0003448_altered_tumor_morphology | 1.72689905 |
| 43 | MP0001845_abnormal_inflammatory_respons | 1.69684191 |
| 44 | MP0002009_preneoplasia | 1.61848066 |
| 45 | MP0004808_abnormal_hematopoietic_stem | 1.60023982 |
| 46 | MP0009278_abnormal_bone_marrow | 1.42154432 |
| 47 | MP0003191_abnormal_cellular_cholesterol | 1.37098164 |
| 48 | MP0000465_gastrointestinal_hemorrhage | 1.30224525 |
| 49 | MP0000490_abnormal_crypts_of | 1.28852247 |
| 50 | MP0002877_abnormal_melanocyte_morpholog | 1.25774269 |
| 51 | MP0005174_abnormal_tail_pigmentation | 1.20967645 |
| 52 | MP0002019_abnormal_tumor_incidence | 1.20515247 |
| 53 | MP0005397_hematopoietic_system_phenotyp | 1.19947439 |
| 54 | MP0001545_abnormal_hematopoietic_system | 1.19947439 |
| 55 | MP0010352_gastrointestinal_tract_polyps | 1.17400934 |
| 56 | MP0002138_abnormal_hepatobiliary_system | 1.16430993 |
| 57 | MP0001853_heart_inflammation | 1.12411150 |
| 58 | MP0002998_abnormal_bone_remodeling | 1.10055799 |
| 59 | MP0003828_pulmonary_edema | 1.09395070 |
| 60 | MP0005409_darkened_coat_color | 1.02219349 |
| 61 | MP0001533_abnormal_skeleton_physiology | 0.98070215 |
| 62 | MP0005075_abnormal_melanosome_morpholog | 0.97132297 |
| 63 | MP0008961_abnormal_basal_metabolism | 0.96378739 |
| 64 | MP0005310_abnormal_salivary_gland | 0.95966482 |
| 65 | MP0003303_peritoneal_inflammation | 0.95595727 |
| 66 | MP0001986_abnormal_taste_sensitivity | 0.94667146 |
| 67 | MP0008469_abnormal_protein_level | 0.94040481 |
| 68 | MP0010094_abnormal_chromosome_stability | 0.92281258 |
| 69 | MP0002876_abnormal_thyroid_physiology | 0.92145032 |
| 70 | MP0005377_hearing/vestibular/ear_phenot | 0.88317999 |
| 71 | MP0003878_abnormal_ear_physiology | 0.88317999 |
| 72 | MP0003638_abnormal_response/metabolism_ | 0.87490990 |
| 73 | MP0005023_abnormal_wound_healing | 0.85614239 |
| 74 | MP0001851_eye_inflammation | 0.83680477 |
| 75 | MP0008007_abnormal_cellular_replicative | 0.83646128 |
| 76 | MP0008877_abnormal_DNA_methylation | 0.83526156 |
| 77 | MP0001765_abnormal_ion_homeostasis | 0.83153732 |
| 78 | MP0003183_abnormal_peptide_metabolism | 0.81844543 |
| 79 | MP0002095_abnormal_skin_pigmentation | 0.76326739 |
| 80 | MP0004510_myositis | 0.76070088 |
| 81 | MP0000015_abnormal_ear_pigmentation | 0.74662532 |
| 82 | MP0001348_abnormal_lacrimal_gland | 0.73801558 |
| 83 | MP0004147_increased_porphyrin_level | 0.71029716 |
| 84 | MP0003656_abnormal_erythrocyte_physiolo | 0.70655134 |
| 85 | MP0003795_abnormal_bone_structure | 0.69963294 |
| 86 | MP0009765_abnormal_xenobiotic_induced | 0.68671100 |
| 87 | MP0000249_abnormal_blood_vessel | 0.68449102 |
| 88 | MP0004130_abnormal_muscle_cell | 0.68021662 |
| 89 | MP0009763_increased_sensitivity_to | 0.66471196 |
| 90 | MP0001243_abnormal_dermal_layer | 0.65547174 |
| 91 | MP0008057_abnormal_DNA_replication | 0.64123159 |
| 92 | MP0004043_abnormal_pH_regulation | 0.63919710 |
| 93 | MP0001501_abnormal_sleep_pattern | 0.63815210 |
| 94 | MP0003252_abnormal_bile_duct | 0.60361948 |
| 95 | MP0000477_abnormal_intestine_morphology | 0.60319107 |
| 96 | MP0002136_abnormal_kidney_physiology | 0.60090298 |
| 97 | MP0003077_abnormal_cell_cycle | 0.59300784 |
| 98 | MP0003453_abnormal_keratinocyte_physiol | 0.57804827 |
| 99 | MP0005076_abnormal_cell_differentiation | 0.56130188 |
| 100 | MP0001919_abnormal_reproductive_system | 0.55815811 |
| 101 | MP0001216_abnormal_epidermal_layer | 0.53929318 |
| 102 | MP0004957_abnormal_blastocyst_morpholog | 0.53687214 |
| 103 | MP0001663_abnormal_digestive_system | 0.51173532 |
| 104 | MP0000609_abnormal_liver_physiology | 0.50862293 |
| 105 | MP0003045_fibrosis | 0.50748410 |
| 106 | MP0002163_abnormal_gland_morphology | 0.50172595 |
| 107 | MP0004134_abnormal_chest_morphology | 0.49642372 |
| 108 | MP0000367_abnormal_coat/_hair | 0.49414513 |
| 109 | MP0006072_abnormal_retinal_apoptosis | 0.47587507 |
| 110 | MP0003279_aneurysm | 0.46445401 |
| 111 | MP0008873_increased_physiological_sensi | 0.46189415 |
| 112 | MP0008770_decreased_survivor_rate | 0.45655906 |
| 113 | MP0001191_abnormal_skin_condition | 0.45633185 |
| 114 | MP0002653_abnormal_ependyma_morphology | 0.45140102 |
| 115 | MP0009764_decreased_sensitivity_to | 0.43669167 |
| 116 | MP0006054_spinal_hemorrhage | 0.43192477 |
| 117 | MP0001879_abnormal_lymphatic_vessel | 0.42807900 |
| 118 | MP0005166_decreased_susceptibility_to | 0.42422693 |
| 119 | MP0008058_abnormal_DNA_repair | 0.42289891 |
| 120 | MP0004185_abnormal_adipocyte_glucose | 0.42261683 |
| 121 | MP0003566_abnormal_cell_adhesion | 0.41650507 |
| 122 | MP0002089_abnormal_postnatal_growth/wei | 0.41472561 |
| 123 | MP0003091_abnormal_cell_migration | 0.40316286 |
| 124 | MP0005390_skeleton_phenotype | 0.40147129 |
| 125 | MP0004885_abnormal_endolymph | 0.39983983 |
| 126 | MP0010329_abnormal_lipoprotein_level | 0.39318076 |
| 127 | MP0000920_abnormal_myelination | 0.39121805 |
| 128 | MP0002083_premature_death | 0.38908645 |
| 129 | MP0005167_abnormal_blood-brain_barrier | 0.38515029 |
| 130 | MP0003172_abnormal_lysosome_physiology | 0.36387679 |
| 131 | MP0003787_abnormal_imprinting | 0.36294560 |
| 132 | MP0002693_abnormal_pancreas_physiology | 0.35930614 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of T cell number (HP:0011839) | 9.91596712 |
| 2 | Severe combined immunodeficiency (HP:0004430) | 5.84216628 |
| 3 | Abnormality of T cells (HP:0002843) | 5.81914403 |
| 4 | Combined immunodeficiency (HP:0005387) | 5.81523982 |
| 5 | Recurrent viral infections (HP:0004429) | 5.01294937 |
| 6 | Eosinophilia (HP:0001880) | 4.77136518 |
| 7 | Thyroiditis (HP:0100646) | 4.72319776 |
| 8 | Panhypogammaglobulinemia (HP:0003139) | 4.68951268 |
| 9 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.65266277 |
| 10 | Abnormality of eosinophils (HP:0001879) | 4.37427947 |
| 11 | Recurrent fungal infections (HP:0002841) | 4.25641626 |
| 12 | Abnormality of B cell number (HP:0010975) | 4.21551471 |
| 13 | B lymphocytopenia (HP:0010976) | 4.21551471 |
| 14 | Nasal polyposis (HP:0100582) | 3.98957146 |
| 15 | Myositis (HP:0100614) | 3.95725835 |
| 16 | Granulocytopenia (HP:0001913) | 3.94848522 |
| 17 | Hypoplasia of the thymus (HP:0000778) | 3.85442421 |
| 18 | IgG deficiency (HP:0004315) | 3.85156595 |
| 19 | Abnormality of the fingertips (HP:0001211) | 3.75314128 |
| 20 | Chronic otitis media (HP:0000389) | 3.67673366 |
| 21 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.62020552 |
| 22 | Leukocytosis (HP:0001974) | 3.58041710 |
| 23 | Pustule (HP:0200039) | 3.57895056 |
| 24 | Autoimmune hemolytic anemia (HP:0001890) | 3.51579659 |
| 25 | Joint swelling (HP:0001386) | 3.40258790 |
| 26 | Stomatitis (HP:0010280) | 3.36749980 |
| 27 | Autoimmune thrombocytopenia (HP:0001973) | 3.31792481 |
| 28 | Recurrent bronchitis (HP:0002837) | 3.26728136 |
| 29 | Anorexia (HP:0002039) | 3.19797336 |
| 30 | Abnormality of the nasal mucosa (HP:0000433) | 3.17341076 |
| 31 | Meningitis (HP:0001287) | 3.07404865 |
| 32 | Optic neuritis (HP:0100653) | 3.04690399 |
| 33 | Retrobulbar optic neuritis (HP:0100654) | 3.04690399 |
| 34 | Stomach cancer (HP:0012126) | 3.04490155 |
| 35 | Encephalitis (HP:0002383) | 3.01833430 |
| 36 | IgM deficiency (HP:0002850) | 2.93777094 |
| 37 | Keratitis (HP:0000491) | 2.85653996 |
| 38 | Recurrent cutaneous fungal infections (HP:0011370) | 2.81281580 |
| 39 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.81281580 |
| 40 | Spontaneous hematomas (HP:0007420) | 2.81272369 |
| 41 | Alveolar cell carcinoma (HP:0006519) | 2.79894461 |
| 42 | Glomerulopathy (HP:0100820) | 2.77351959 |
| 43 | Chronic diarrhea (HP:0002028) | 2.75451097 |
| 44 | Lymphopenia (HP:0001888) | 2.74951931 |
| 45 | Orchitis (HP:0100796) | 2.70793360 |
| 46 | Prolonged bleeding time (HP:0003010) | 2.65462652 |
| 47 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.64191410 |
| 48 | Agammaglobulinemia (HP:0004432) | 2.60999235 |
| 49 | Polyneuropathy (HP:0001271) | 2.57049629 |
| 50 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.56958941 |
| 51 | Hypoproteinemia (HP:0003075) | 2.55559818 |
| 52 | Abnormality of macrophages (HP:0004311) | 2.55213214 |
| 53 | Increased IgE level (HP:0003212) | 2.54828782 |
| 54 | Abnormality of oral frenula (HP:0000190) | 2.52153080 |
| 55 | Vertigo (HP:0002321) | 2.51482736 |
| 56 | Eczematoid dermatitis (HP:0000976) | 2.51261255 |
| 57 | Papilledema (HP:0001085) | 2.51095536 |
| 58 | Persistence of primary teeth (HP:0006335) | 2.46130152 |
| 59 | Abnormality of the pleura (HP:0002103) | 2.43379404 |
| 60 | Abnormal platelet volume (HP:0011876) | 2.42894929 |
| 61 | Keratoconjunctivitis sicca (HP:0001097) | 2.41465081 |
| 62 | Abnormal foot bone ossification (HP:0010675) | 2.39744443 |
| 63 | Inflammation of the large intestine (HP:0002037) | 2.37019493 |
| 64 | Verrucae (HP:0200043) | 2.36392779 |
| 65 | Papilloma (HP:0012740) | 2.36392779 |
| 66 | Premature loss of primary teeth (HP:0006323) | 2.34604040 |
| 67 | Gastrointestinal inflammation (HP:0004386) | 2.32857523 |
| 68 | Lymphoma (HP:0002665) | 2.31317586 |
| 69 | Recurrent abscess formation (HP:0002722) | 2.30623576 |
| 70 | Hemoptysis (HP:0002105) | 2.29903927 |
| 71 | Prostate neoplasm (HP:0100787) | 2.26607856 |
| 72 | Increased IgM level (HP:0003496) | 2.24249096 |
| 73 | Epistaxis (HP:0000421) | 2.23614844 |
| 74 | Basal cell carcinoma (HP:0002671) | 2.21835959 |
| 75 | Gastrointestinal infarctions (HP:0005244) | 2.21507555 |
| 76 | Hemiplegia (HP:0002301) | 2.21254998 |
| 77 | Acne (HP:0001061) | 2.20188991 |
| 78 | Epiphyseal dysplasia (HP:0002656) | 2.15627431 |
| 79 | Keratoconjunctivitis (HP:0001096) | 2.14763887 |
| 80 | Abnormality of T cell physiology (HP:0011840) | 2.12658447 |
| 81 | Obstructive lung disease (HP:0006536) | 2.12347670 |
| 82 | Chronic obstructive pulmonary disease (HP:0006510) | 2.12347670 |
| 83 | Vasculitis (HP:0002633) | 2.11859755 |
| 84 | Gastrointestinal stroma tumor (HP:0100723) | 2.11811122 |
| 85 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.11222614 |
| 86 | Pulmonary embolism (HP:0002204) | 2.03919994 |
| 87 | Pulmonary infiltrates (HP:0002113) | 2.03840623 |
| 88 | Abnormality of the pericardium (HP:0001697) | 2.03817775 |
| 89 | Bicuspid aortic valve (HP:0001647) | 2.03293329 |
| 90 | Thrombophlebitis (HP:0004418) | 2.00579436 |
| 91 | Abnormality of the endocardium (HP:0004306) | 2.00032074 |
| 92 | T lymphocytopenia (HP:0005403) | 10.4505751 |
| 93 | Pancreatitis (HP:0001733) | 1.99101858 |
| 94 | Urticaria (HP:0001025) | 1.97006063 |
| 95 | Hypergammaglobulinemia (HP:0010702) | 1.96743637 |
| 96 | Arterial thrombosis (HP:0004420) | 1.96740732 |
| 97 | Mediastinal lymphadenopathy (HP:0100721) | 1.95758368 |
| 98 | Recurrent otitis media (HP:0000403) | 1.94962860 |
| 99 | Hypochromic anemia (HP:0001931) | 1.94503277 |
| 100 | Broad palm (HP:0001169) | 1.92880611 |
| 101 | Renal cortical cysts (HP:0000803) | 1.88805618 |
| 102 | Chronic sinusitis (HP:0011109) | 1.88132716 |
| 103 | Abnormality of the prostate (HP:0008775) | 1.87380194 |
| 104 | Dislocated radial head (HP:0003083) | 1.87319118 |
| 105 | Irregular epiphyses (HP:0010582) | 1.86803541 |
| 106 | Increased mean platelet volume (HP:0011877) | 1.84758757 |
| 107 | Recurrent skin infections (HP:0001581) | 1.84661886 |
| 108 | Diplopia (HP:0000651) | 1.83631734 |
| 109 | Abnormality of binocular vision (HP:0011514) | 1.83631734 |
| 110 | Ureteral stenosis (HP:0000071) | 1.82952043 |
| 111 | Increased density of long bones (HP:0006392) | 1.81572110 |
| 112 | Aortic aneurysm (HP:0004942) | 1.79185922 |
| 113 | Trigonocephaly (HP:0000243) | 1.75496823 |
| 114 | Abnormality of the radial head (HP:0003995) | 1.73108050 |
| 115 | Bronchitis (HP:0012387) | 1.70225924 |
| 116 | Gingival bleeding (HP:0000225) | 1.69740663 |
| 117 | Abnormal tarsal ossification (HP:0008369) | 1.69206627 |
| 118 | Frequent falls (HP:0002359) | 1.68261683 |
| 119 | Bronchiectasis (HP:0002110) | 1.66499780 |
| 120 | Chest pain (HP:0100749) | 1.66011585 |
| 121 | Abnormality of the thymus (HP:0000777) | 1.65827754 |
| 122 | Recurrent sinusitis (HP:0011108) | 1.65424626 |
| 123 | Recurrent bacterial skin infections (HP:0005406) | 1.65200765 |
| 124 | Ureteral obstruction (HP:0006000) | 1.64729258 |
| 125 | Abnormal platelet function (HP:0011869) | 1.63378299 |
| 126 | Impaired platelet aggregation (HP:0003540) | 1.63378299 |
| 127 | Petechiae (HP:0000967) | 1.61597737 |
| 128 | Gangrene (HP:0100758) | 1.61207795 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.09355842 |
| 2 | MAP4K1 | 5.02779380 |
| 3 | TAOK3 | 4.37922440 |
| 4 | ITK | 3.71718486 |
| 5 | GRK6 | 3.30081693 |
| 6 | STK10 | 3.21054172 |
| 7 | JAK3 | 2.87644698 |
| 8 | ZAP70 | 2.73615405 |
| 9 | MST4 | 2.67520246 |
| 10 | MAP2K2 | 2.53281755 |
| 11 | CSK | 2.34928033 |
| 12 | TLK1 | 2.19200737 |
| 13 | FGFR4 | 2.14376508 |
| 14 | EEF2K | 2.02036717 |
| 15 | NLK | 2.00082060 |
| 16 | TYK2 | 1.92401981 |
| 17 | RIPK4 | 1.86229093 |
| 18 | LCK | 1.81907961 |
| 19 | FGFR3 | 1.79662678 |
| 20 | IKBKE | 1.66752796 |
| 21 | PRKCH | 1.65465782 |
| 22 | MAP3K10 | 1.65319914 |
| 23 | KIT | 1.61800230 |
| 24 | JAK1 | 1.60721353 |
| 25 | SYK | 1.60190276 |
| 26 | BMPR2 | 1.58703922 |
| 27 | MUSK | 1.46350938 |
| 28 | CLK1 | 1.44399820 |
| 29 | TEC | 1.42372710 |
| 30 | MATK | 1.40406284 |
| 31 | BTK | 1.39431488 |
| 32 | MAP3K14 | 1.38975128 |
| 33 | HCK | 1.38159265 |
| 34 | MARK3 | 1.30224879 |
| 35 | TNK2 | 1.25258274 |
| 36 | PRKD2 | 1.22455291 |
| 37 | PIM1 | 1.21754493 |
| 38 | LRRK2 | 1.21045100 |
| 39 | MAP3K7 | 1.20181324 |
| 40 | SIK2 | 1.20097331 |
| 41 | PKN2 | 1.16941876 |
| 42 | PRKCQ | 1.11676137 |
| 43 | NME2 | 1.10760117 |
| 44 | TSSK6 | 1.10415895 |
| 45 | MAP4K2 | 1.08189312 |
| 46 | TGFBR2 | 1.07771274 |
| 47 | KDR | 1.04853202 |
| 48 | PDGFRB | 1.04841648 |
| 49 | IRAK4 | 0.98525681 |
| 50 | ARAF | 0.96667953 |
| 51 | BLK | 0.96346089 |
| 52 | CDK4 | 0.96155324 |
| 53 | FGFR2 | 0.95395962 |
| 54 | FES | 0.92365123 |
| 55 | TYRO3 | 0.91460578 |
| 56 | TBK1 | 0.91453412 |
| 57 | CAMKK2 | 0.88712781 |
| 58 | IRAK1 | 0.87973723 |
| 59 | EPHB1 | 0.87577388 |
| 60 | TRIB3 | 0.84760211 |
| 61 | CDK12 | 0.83547977 |
| 62 | GRK7 | 0.83532112 |
| 63 | MAPK7 | 0.82117491 |
| 64 | HIPK2 | 0.81060242 |
| 65 | MAP3K13 | 0.80329276 |
| 66 | TESK2 | 0.77830919 |
| 67 | JAK2 | 0.77085476 |
| 68 | STK24 | 0.76994907 |
| 69 | EIF2AK2 | 0.72479029 |
| 70 | MARK2 | 0.71246799 |
| 71 | YES1 | 0.70100500 |
| 72 | SIK3 | 0.69754239 |
| 73 | CDK9 | 0.69372146 |
| 74 | RPS6KB2 | 0.69191824 |
| 75 | MELK | 0.67124054 |
| 76 | PIK3CG | 0.65928307 |
| 77 | MKNK2 | 0.64090232 |
| 78 | PASK | 0.63216687 |
| 79 | RPS6KA4 | 0.60984833 |
| 80 | CDK3 | 0.59498964 |
| 81 | PDK1 | 0.59290255 |
| 82 | MAPK12 | 0.59276604 |
| 83 | STK4 | 0.58886324 |
| 84 | PRPF4B | 0.58317867 |
| 85 | LYN | 0.57516456 |
| 86 | TTN | 0.57384305 |
| 87 | IKBKB | 0.54767216 |
| 88 | CDK6 | 0.53064786 |
| 89 | MOS | 0.51961639 |
| 90 | ALK | 0.51660054 |
| 91 | FGR | 0.51576498 |
| 92 | TRPM7 | 0.51337044 |
| 93 | MAPK4 | 0.50464784 |
| 94 | ZAK | 0.50071342 |
| 95 | PTK6 | 0.49714773 |
| 96 | FYN | 0.48245690 |
| 97 | STK38 | 0.47819262 |
| 98 | BRD4 | 0.47786431 |
| 99 | INSR | 0.47080644 |
| 100 | MAPKAPK2 | 0.46838989 |
| 101 | STK11 | 0.45182658 |
| 102 | RAF1 | 0.43878842 |
| 103 | SGK3 | 0.43562262 |
| 104 | DMPK | 0.42816392 |
| 105 | FGFR1 | 0.42000131 |
| 106 | NEK6 | 0.39985122 |
| 107 | NUAK1 | 0.37748004 |
| 108 | MAP2K3 | 0.34982002 |
| 109 | RET | 0.34414313 |
| 110 | CDC7 | 0.33800774 |
| 111 | MAPK13 | 0.31474817 |
| 112 | EPHA3 | 0.29978527 |
| 113 | CSF1R | 0.28306534 |
| 114 | RPS6KA6 | 0.28137739 |
| 115 | MAPK3 | 0.27920530 |
| 116 | ADRBK2 | 0.27579609 |
| 117 | TGFBR1 | 0.26839079 |
| 118 | TAOK1 | 0.26828296 |
| 119 | MAP3K1 | 0.26673318 |
| 120 | KSR2 | 0.26528937 |
| 121 | RPS6KC1 | 0.26326757 |
| 122 | RPS6KL1 | 0.26326757 |
| 123 | ABL1 | 0.26285419 |
| 124 | RPS6KA2 | 0.26129954 |
| 125 | PIK3CA | 0.25920030 |
| 126 | IGF1R | 0.25740008 |
| 127 | PRKD1 | 0.25217865 |
| 128 | NEK2 | 0.24642042 |
| 129 | MAPK11 | 0.24597665 |
| 130 | MAP3K8 | 0.24128719 |
| 131 | MAP2K6 | 0.23876394 |
| 132 | CSNK1A1L | 0.23779582 |
| 133 | CAMKK1 | 0.23560706 |
| 134 | CHUK | 0.22449228 |
| 135 | MAP2K1 | 0.19110526 |
| 136 | EGFR | 0.17906837 |
| 137 | PRKCD | 0.17040222 |
| 138 | MAP3K11 | 0.15585477 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.72482589 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.54671427 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.19839538 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.96330904 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.27837531 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.75420206 |
| 7 | Measles_Homo sapiens_hsa05162 | 2.71772736 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.43493948 |
| 9 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.09709824 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.94320631 |
| 11 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.89560001 |
| 12 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.75412386 |
| 13 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.67842494 |
| 14 | Leishmaniasis_Homo sapiens_hsa05140 | 1.67527019 |
| 15 | Allograft rejection_Homo sapiens_hsa05330 | 1.59564427 |
| 16 | Viral myocarditis_Homo sapiens_hsa05416 | 1.51413266 |
| 17 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.49933421 |
| 18 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.48799542 |
| 19 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.45809953 |
| 20 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.42492842 |
| 21 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.41841902 |
| 22 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.36645967 |
| 23 | Colorectal cancer_Homo sapiens_hsa05210 | 1.35220403 |
| 24 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.25365186 |
| 25 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.24445397 |
| 26 | HTLV-I infection_Homo sapiens_hsa05166 | 1.18916182 |
| 27 | Hepatitis B_Homo sapiens_hsa05161 | 1.18893676 |
| 28 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.14426844 |
| 29 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.11821717 |
| 30 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.11591606 |
| 31 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.09284481 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.05144565 |
| 33 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.05026862 |
| 34 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.03652381 |
| 35 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.02685705 |
| 36 | Platelet activation_Homo sapiens_hsa04611 | 1.02583373 |
| 37 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.01566418 |
| 38 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.96173455 |
| 39 | Ribosome_Homo sapiens_hsa03010 | 0.95467728 |
| 40 | Influenza A_Homo sapiens_hsa05164 | 0.95051269 |
| 41 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.91586711 |
| 42 | Endometrial cancer_Homo sapiens_hsa05213 | 0.89607558 |
| 43 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.87825742 |
| 44 | Apoptosis_Homo sapiens_hsa04210 | 0.86212601 |
| 45 | Thyroid cancer_Homo sapiens_hsa05216 | 0.85001849 |
| 46 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.82742740 |
| 47 | Asthma_Homo sapiens_hsa05310 | 0.82616412 |
| 48 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.80267918 |
| 49 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.79387755 |
| 50 | Shigellosis_Homo sapiens_hsa05131 | 0.77910111 |
| 51 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.77670776 |
| 52 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.75170560 |
| 53 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.74363890 |
| 54 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.73318819 |
| 55 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.72868751 |
| 56 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.71026172 |
| 57 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.70639874 |
| 58 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.69688918 |
| 59 | Spliceosome_Homo sapiens_hsa03040 | 0.69413695 |
| 60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.68934967 |
| 61 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.68370723 |
| 62 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.66967197 |
| 63 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.66112529 |
| 64 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.66068157 |
| 65 | Malaria_Homo sapiens_hsa05144 | 0.65878259 |
| 66 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.64454821 |
| 67 | Hepatitis C_Homo sapiens_hsa05160 | 0.64043251 |
| 68 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.59639179 |
| 69 | Prostate cancer_Homo sapiens_hsa05215 | 0.59605809 |
| 70 | Legionellosis_Homo sapiens_hsa05134 | 0.58556850 |
| 71 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.58385897 |
| 72 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.55783076 |
| 73 | DNA replication_Homo sapiens_hsa03030 | 0.54143012 |
| 74 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.53892191 |
| 75 | Adherens junction_Homo sapiens_hsa04520 | 0.53227882 |
| 76 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.52851512 |
| 77 | Tuberculosis_Homo sapiens_hsa05152 | 0.51879359 |
| 78 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.51758791 |
| 79 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.48750626 |
| 80 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.47355757 |
| 81 | Endocytosis_Homo sapiens_hsa04144 | 0.46613413 |
| 82 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.45415202 |
| 83 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.44466793 |
| 84 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.44313049 |
| 85 | Salmonella infection_Homo sapiens_hsa05132 | 0.43669371 |
| 86 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.43399597 |
| 87 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.42688330 |
| 88 | Phototransduction_Homo sapiens_hsa04744 | 0.42101313 |
| 89 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.42099642 |
| 90 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.40684536 |
| 91 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.40502895 |
| 92 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.40476645 |
| 93 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.38735024 |
| 94 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.38410219 |
| 95 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.38191699 |
| 96 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.36913112 |
| 97 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.36523071 |
| 98 | Focal adhesion_Homo sapiens_hsa04510 | 0.35852401 |
| 99 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.35489595 |
| 100 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.34088963 |
| 101 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.33522509 |
| 102 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.33255860 |
| 103 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.32658835 |
| 104 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.32559625 |
| 105 | Olfactory transduction_Homo sapiens_hsa04740 | 0.32434031 |
| 106 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.31803410 |
| 107 | Pathways in cancer_Homo sapiens_hsa05200 | 0.31762001 |
| 108 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.30716891 |
| 109 | Pertussis_Homo sapiens_hsa05133 | 0.30237427 |
| 110 | RNA degradation_Homo sapiens_hsa03018 | 0.30234290 |
| 111 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.28526747 |
| 112 | Lysine degradation_Homo sapiens_hsa00310 | 0.26577794 |
| 113 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.26125792 |
| 114 | Base excision repair_Homo sapiens_hsa03410 | 0.25781141 |
| 115 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.25691419 |
| 116 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.24434797 |
| 117 | Lysosome_Homo sapiens_hsa04142 | 0.23961427 |
| 118 | Insulin resistance_Homo sapiens_hsa04931 | 0.23740530 |
| 119 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.18212593 |
| 120 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.18153177 |
| 121 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.18007316 |
| 122 | Long-term potentiation_Homo sapiens_hsa04720 | 0.16317342 |
| 123 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.15858943 |
| 124 | Phagosome_Homo sapiens_hsa04145 | 0.15242599 |

