TRDJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)9.50477667
2positive regulation of extracellular matrix organization (GO:1903055)8.76306346
3limb bud formation (GO:0060174)8.30822935
4notochord development (GO:0030903)7.95246928
5endochondral ossification (GO:0001958)7.38431623
6replacement ossification (GO:0036075)7.38431623
7negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)7.32093128
8collagen fibril organization (GO:0030199)6.97827496
9nucleotide-sugar biosynthetic process (GO:0009226)6.40219523
10cartilage development (GO:0051216)6.31264532
11sphingomyelin metabolic process (GO:0006684)6.29070680
12cellular glucuronidation (GO:0052695)6.21806715
13proteoglycan metabolic process (GO:0006029)5.96916159
14regulation of extracellular matrix disassembly (GO:0010715)5.79039783
15hypotonic response (GO:0006971)5.67949737
16glucuronate metabolic process (GO:0019585)5.42238955
17uronic acid metabolic process (GO:0006063)5.42238955
18regulation of extracellular matrix organization (GO:1903053)5.39308034
19chondrocyte differentiation (GO:0002062)5.37898738
20chondroitin sulfate biosynthetic process (GO:0030206)5.28582222
21protein retention in ER lumen (GO:0006621)5.16522164
22collagen catabolic process (GO:0030574)4.98862441
23embryonic skeletal joint morphogenesis (GO:0060272)4.98025926
24skeletal system development (GO:0001501)4.96653745
25positive regulation of chondrocyte differentiation (GO:0032332)4.95712521
26UDP-N-acetylglucosamine metabolic process (GO:0006047)4.82109865
27keratan sulfate biosynthetic process (GO:0018146)4.72939841
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.71747352
29iron ion import (GO:0097286)4.70394226
30positive regulation of hormone biosynthetic process (GO:0046886)4.65605813
31collagen metabolic process (GO:0032963)4.62431775
32endothelial cell morphogenesis (GO:0001886)4.56841902
33multicellular organismal catabolic process (GO:0044243)4.55549021
34lipopolysaccharide biosynthetic process (GO:0009103)4.53205037
35regulation of plasminogen activation (GO:0010755)4.42006693
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.31881488
37multicellular organismal macromolecule metabolic process (GO:0044259)4.31328172
38connective tissue development (GO:0061448)4.24171056
39multicellular organismal metabolic process (GO:0044236)4.13720272
40positive regulation of cartilage development (GO:0061036)4.10929399
41positive regulation of endothelial cell differentiation (GO:0045603)3.98205450
42myelin assembly (GO:0032288)3.96270463
43oligosaccharide catabolic process (GO:0009313)3.86361519
44lipopolysaccharide metabolic process (GO:0008653)3.83691173
45glycoprotein metabolic process (GO:0009100)3.80550686
46extracellular matrix disassembly (GO:0022617)3.80485586
47keratan sulfate metabolic process (GO:0042339)3.74355067
48response to magnesium ion (GO:0032026)3.70592625
49cholesterol biosynthetic process (GO:0006695)3.65413505
50ossification (GO:0001503)3.62961733
51cellular response to BMP stimulus (GO:0071773)3.62950015
52response to BMP (GO:0071772)3.62950015
53nucleotide-sugar metabolic process (GO:0009225)3.62936137
54type B pancreatic cell development (GO:0003323)3.61270579
55glycosphingolipid catabolic process (GO:0046479)3.42211454
56regulation of type B pancreatic cell apoptotic process (GO:2000674)3.40081096
57positive regulation of hormone metabolic process (GO:0032352)3.38885468
58COPII vesicle coating (GO:0048208)3.34493696
59glycosaminoglycan biosynthetic process (GO:0006024)3.32436146
60endocardial cushion morphogenesis (GO:0003203)3.31499163
61neutrophil activation (GO:0042119)3.30427334
62aminoglycan biosynthetic process (GO:0006023)3.26703589
63sterol biosynthetic process (GO:0016126)3.26668086
64negative regulation of acute inflammatory response (GO:0002674)3.22945185
65chondroitin sulfate metabolic process (GO:0030204)3.22191248
66positive regulation of steroid hormone secretion (GO:2000833)3.21857285
67uterus development (GO:0060065)3.20722338
68regulation of steroid hormone biosynthetic process (GO:0090030)3.18976887
69endodermal cell differentiation (GO:0035987)3.17067740
70regulation of response to osmotic stress (GO:0047484)3.14702419
71positive regulation of alcohol biosynthetic process (GO:1902932)3.13667553
72regulation of cell maturation (GO:1903429)3.11563511
73glycosaminoglycan catabolic process (GO:0006027)3.08489461
74negative regulation of glycogen biosynthetic process (GO:0045719)3.05203909
75regulation of chondrocyte differentiation (GO:0032330)3.04992723
76extracellular matrix organization (GO:0030198)3.04380816
77glycolipid catabolic process (GO:0019377)3.03684763
78peptidyl-proline hydroxylation (GO:0019511)3.03440383
79extracellular structure organization (GO:0043062)3.03358585
80positive regulation of neurological system process (GO:0031646)3.02972608
81COPI coating of Golgi vesicle (GO:0048205)3.02476561
82Golgi transport vesicle coating (GO:0048200)3.02476561
83regulation of energy homeostasis (GO:2000505)3.02067824
84regulation of corticosteroid hormone secretion (GO:2000846)3.00164041
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.98990634
86sulfur compound catabolic process (GO:0044273)2.97319922
87regulation of cartilage development (GO:0061035)2.96903128
88positive regulation of vesicle fusion (GO:0031340)2.95306702
89tooth mineralization (GO:0034505)2.93587001
90positive regulation of steroid biosynthetic process (GO:0010893)2.90287558
91granulocyte activation (GO:0036230)2.88666475
92aminoglycan catabolic process (GO:0006026)2.88384421
93hyperosmotic salinity response (GO:0042538)2.83296605
94negative regulation of glycogen metabolic process (GO:0070874)2.82263186
95regulation of bone mineralization (GO:0030500)2.80785780
96negative regulation of endothelial cell proliferation (GO:0001937)2.73716145
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.7220559
98cartilage condensation (GO:0001502)12.2094005
99cell aggregation (GO:0098743)12.2094005
100chondrocyte development (GO:0002063)10.8885920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.67910943
2AR_21572438_ChIP-Seq_LNCaP_Human5.39187288
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.15026893
4SMAD_19615063_ChIP-ChIP_OVARY_Human4.49084210
5GATA1_22025678_ChIP-Seq_K562_Human3.93978028
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60100742
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.70974133
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55246553
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.42814835
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34788244
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19528960
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.07930023
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02591218
14WT1_19549856_ChIP-ChIP_CCG9911_Human1.99501796
15CJUN_26792858_Chip-Seq_BT549_Human1.91606620
16RXR_22108803_ChIP-Seq_LS180_Human1.78502373
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.73904268
18VDR_24787735_ChIP-Seq_THP-1_Human1.72773945
19RUNX_20019798_ChIP-Seq_JUKART_Human1.71191068
20CLOCK_20551151_ChIP-Seq_293T_Human1.62467253
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60969494
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.59905418
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55557038
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55037902
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46784842
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45742259
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44291824
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42910847
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40948083
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40618515
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40618515
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.34485533
33JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34227346
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33281945
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33281945
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.31939662
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.30812910
38TP53_18474530_ChIP-ChIP_U2OS_Human1.28842767
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.26543137
40EGR1_19032775_ChIP-ChIP_M12_Human1.26346935
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.24064831
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20905182
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20844485
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.18833885
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.17669084
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16303160
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15335816
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14135333
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13648607
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13365610
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11748069
52CTCF_21964334_Chip-Seq_Bcells_Human1.11724650
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11382027
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09747800
55SA1_22415368_ChIP-Seq_MEFs_Mouse1.08241655
56SOX2_20726797_ChIP-Seq_SW620_Human1.07445714
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06401880
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06201193
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.04201052
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01014902
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01014902
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00404814
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99494729
64GATA2_21666600_ChIP-Seq_HMVEC_Human0.99056272
65ELF5_23300383_ChIP-Seq_T47D_Human0.99043618
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98227193
67EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93728980
68RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93728980
69JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93647695
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91871931
71TBX20_22080862_ChIP-Seq_HEART_Mouse0.89977280
72TBX20_22328084_ChIP-Seq_HEART_Mouse0.89977280
73KDM2B_26808549_Chip-Seq_K562_Human0.88048970
74P53_22387025_ChIP-Seq_ESCs_Mouse0.86492575
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85699950
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85258629
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85230167
78MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85156760
79SMRT_27268052_Chip-Seq_Bcells_Human0.84853370
80NANOG_18555785_Chip-Seq_ESCs_Mouse0.84321157
81BRD4_25478319_ChIP-Seq_HGPS_Human0.83706679
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82786212
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82544997
84NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82542764
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82340489
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82132584
87SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81368168
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80984827
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.80962015
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80955413
91GATA3_27048872_Chip-Seq_THYMUS_Human0.80675186
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.80563732
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79850320
94SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78757183
95TCF4_22108803_ChIP-Seq_LS180_Human0.78443106
96ATF3_27146783_Chip-Seq_COLON_Human0.77782887
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.77459754
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77113217
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.76495254
100MYB_26560356_Chip-Seq_TH2_Human0.76465364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002933_joint_inflammation6.66693453
2MP0002282_abnormal_trachea_morphology5.47287654
3MP0004134_abnormal_chest_morphology5.29164556
4MP0003646_muscle_fatigue4.87399527
5MP0000163_abnormal_cartilage_morphology4.31109365
6MP0009250_abnormal_appendicular_skeleto4.02545623
7MP0005503_abnormal_tendon_morphology3.89600240
8MP0003123_paternal_imprinting3.68186390
9MP0002115_abnormal_skeleton_extremities3.47789272
10MP0002113_abnormal_skeleton_development2.94390889
11MP0003787_abnormal_imprinting2.72813487
12MP0002089_abnormal_postnatal_growth/wei2.70272306
13MP0009384_cardiac_valve_regurgitation2.64235283
14MP0000762_abnormal_tongue_morphology2.60132452
15MP0002163_abnormal_gland_morphology2.58237860
16MP0001533_abnormal_skeleton_physiology2.50185887
17MP0002896_abnormal_bone_mineralization2.46809478
18MP0009780_abnormal_chondrocyte_physiolo2.39910800
19MP0003656_abnormal_erythrocyte_physiolo2.33438545
20MP0005390_skeleton_phenotype2.24386100
21MP0003795_abnormal_bone_structure2.23224943
22MP0001542_abnormal_bone_strength2.22731767
23MP0001299_abnormal_eye_distance/2.14923229
24MP0002109_abnormal_limb_morphology2.08276530
25MP0001270_distended_abdomen1.96534331
26MP0005508_abnormal_skeleton_morphology1.93338827
27MP0000751_myopathy1.91080164
28MP0003436_decreased_susceptibility_to1.81694636
29MP0009697_abnormal_copulation1.60764214
30MP0000465_gastrointestinal_hemorrhage1.52702033
31MP0001663_abnormal_digestive_system1.52418613
32MP0002116_abnormal_craniofacial_bone1.48788678
33MP0001873_stomach_inflammation1.43430969
34MP0003755_abnormal_palate_morphology1.42590720
35MP0002998_abnormal_bone_remodeling1.37957644
36MP0000432_abnormal_head_morphology1.32306272
37MP0003806_abnormal_nucleotide_metabolis1.31975947
38MP0002139_abnormal_hepatobiliary_system1.31613177
39MP0002909_abnormal_adrenal_gland1.31089389
40MP0005379_endocrine/exocrine_gland_phen1.23881018
41MP0005381_digestive/alimentary_phenotyp1.23309054
42MP0002108_abnormal_muscle_morphology1.21278753
43MP0004084_abnormal_cardiac_muscle1.14787854
44MP0000049_abnormal_middle_ear1.11031022
45MP0000343_altered_response_to1.07505777
46MP0003566_abnormal_cell_adhesion1.06894964
47MP0003121_genomic_imprinting1.05385701
48MP0005023_abnormal_wound_healing1.04903978
49MP0002114_abnormal_axial_skeleton1.03173967
50MP0003935_abnormal_craniofacial_develop1.02400588
51MP0008004_abnormal_stomach_pH0.92311618
52MP0002877_abnormal_melanocyte_morpholog0.90826678
53MP0003091_abnormal_cell_migration0.90612686
54MP0002233_abnormal_nose_morphology0.90181055
55MP0005164_abnormal_response_to0.89090193
56MP0002111_abnormal_tail_morphology0.86612867
57MP0005275_abnormal_skin_tensile0.86015848
58MP0004197_abnormal_fetal_growth/weight/0.80445817
59MP0008438_abnormal_cutaneous_collagen0.77124321
60MP0004484_altered_response_of0.73698417
61MP0001790_abnormal_immune_system0.69775688
62MP0005387_immune_system_phenotype0.69775688
63MP0003937_abnormal_limbs/digits/tail_de0.69017392
64MP0002735_abnormal_chemical_nociception0.69014848
65MP0001963_abnormal_hearing_physiology0.68230160
66MP0003763_abnormal_thymus_physiology0.67689813
67MP0005646_abnormal_pituitary_gland0.65547128
68MP0002234_abnormal_pharynx_morphology0.62852945
69MP0004185_abnormal_adipocyte_glucose0.62845489
70MP0003868_abnormal_feces_composition0.61900477
71MP0005076_abnormal_cell_differentiation0.61495903
72MP0002736_abnormal_nociception_after0.61229757
73MP0004272_abnormal_basement_membrane0.61180997
74MP0003279_aneurysm0.61003191
75MP0001943_abnormal_respiration0.59403552
76MP0001243_abnormal_dermal_layer0.52663240
77MP0005623_abnormal_meninges_morphology0.50212092
78MP0003705_abnormal_hypodermis_morpholog0.49218675
79MP0003303_peritoneal_inflammation0.48761950
80MP0002932_abnormal_joint_morphology0.48441839
81MP0003942_abnormal_urinary_system0.46689709
82MP0003195_calcinosis0.46293417
83MP0001853_heart_inflammation0.45360551
84MP0000230_abnormal_systemic_arterial0.44032640
85MP0005166_decreased_susceptibility_to0.43373785
86MP0005670_abnormal_white_adipose0.42987987
87MP0001286_abnormal_eye_development0.42794573
88MP0000685_abnormal_immune_system0.41836008
89MP0003724_increased_susceptibility_to0.40405104
90MP0010030_abnormal_orbit_morphology0.39108619
91MP0005666_abnormal_adipose_tissue0.38323747
92MP0002249_abnormal_larynx_morphology0.38100753
93MP0004036_abnormal_muscle_relaxation0.37662252
94MP0003283_abnormal_digestive_organ0.36223562
95MP0003385_abnormal_body_wall0.35988968
96MP0000613_abnormal_salivary_gland0.35547392
97MP0001177_atelectasis0.33862827
98MP0009765_abnormal_xenobiotic_induced0.33686691
99MP0003448_altered_tumor_morphology0.32808499
100MP0003075_altered_response_to0.29986633

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.65311274
2Irregular epiphyses (HP:0010582)9.53199958
3Vitreoretinal degeneration (HP:0000655)7.59733994
4Small epiphyses (HP:0010585)7.24521845
5Abnormal tarsal ossification (HP:0008369)7.03560782
6Cupped ribs (HP:0000887)6.46302301
7Metaphyseal cupping (HP:0003021)6.31372442
8Metaphyseal dysplasia (HP:0100255)5.95422701
9Hypoplastic ischia (HP:0003175)5.90388504
10Flat capital femoral epiphysis (HP:0003370)5.63336917
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.60985775
12Flat acetabular roof (HP:0003180)5.49997366
13Genu varum (HP:0002970)5.21517307
14Abnormality of the ischium (HP:0003174)5.19953333
15Abnormal foot bone ossification (HP:0010675)5.18265740
16Delayed epiphyseal ossification (HP:0002663)5.17911735
17Abnormality of femoral epiphyses (HP:0006499)4.88843416
18Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.88843416
19Mild short stature (HP:0003502)4.75807430
20Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.50877639
21Absent epiphyses (HP:0010577)4.50877639
22Abnormality of the vertebral endplates (HP:0005106)4.49222712
23Abnormality of the epiphysis of the femoral head (HP:0010574)4.44010657
24Irregular vertebral endplates (HP:0003301)4.36320526
25Arthropathy (HP:0003040)4.23545635
26Short femoral neck (HP:0100864)4.13644639
27Abnormality of the femoral head (HP:0003368)4.09758466
28Metaphyseal irregularity (HP:0003025)3.77220872
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.76556878
30Osteoarthritis (HP:0002758)3.74593739
31Neonatal short-limb short stature (HP:0008921)3.73946818
32Flattened epiphyses (HP:0003071)3.63794797
33Enlarged epiphyses (HP:0010580)3.41317509
34Coxa vara (HP:0002812)3.39466388
35Abnormality of carpal bone ossification (HP:0006257)3.29069105
36Waddling gait (HP:0002515)3.23026110
37Abnormality of incisor morphology (HP:0011063)3.16605219
38Abnormality of the pubic bones (HP:0003172)3.10256897
39Platyspondyly (HP:0000926)3.05565477
40Abnormal vertebral ossification (HP:0100569)3.00355757
41Limited elbow extension (HP:0001377)2.94266570
42Absent frontal sinuses (HP:0002688)2.94244485
43Protuberant abdomen (HP:0001538)2.93296080
44Aplasia/hypoplasia of the femur (HP:0005613)2.93206060
45Stillbirth (HP:0003826)2.92848420
46Ovoid vertebral bodies (HP:0003300)2.90923359
47Vertebral clefting (HP:0008428)2.88808573
48Carpal bone hypoplasia (HP:0001498)2.80150566
49Abnormality of the proximal phalanges of the hand (HP:0009834)2.79103973
50Barrel-shaped chest (HP:0001552)2.78590703
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68435279
52Beaking of vertebral bodies (HP:0004568)2.61817711
53Abnormal hand bone ossification (HP:0010660)2.55013405
54Limited hip movement (HP:0008800)2.53615668
55Abnormal ossification of hand bones (HP:0005921)2.53318072
56Cervical subluxation (HP:0003308)2.51319203
57Lumbar hyperlordosis (HP:0002938)2.49174647
58Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.45390459
59Thoracolumbar scoliosis (HP:0002944)2.44562645
60Thin ribs (HP:0000883)2.44525086
61Exostoses (HP:0100777)2.43329842
62Short middle phalanx of finger (HP:0005819)2.42548747
63Long clavicles (HP:0000890)2.40789366
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40632554
65Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.37234978
66Vertebral hypoplasia (HP:0008417)2.37234978
67Hip contracture (HP:0003273)2.36680481
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.28802756
69Spinal cord compression (HP:0002176)2.28236547
70Fibular hypoplasia (HP:0003038)2.27937041
71Abnormality of the vitreous humor (HP:0004327)2.27720906
72Hypoplasia of the odontoid process (HP:0003311)2.27600364
73Glossoptosis (HP:0000162)2.27138921
74Hypoplastic pelvis (HP:0008839)2.22449878
75Micromelia (HP:0002983)2.20354857
76Abnormality of the acetabulum (HP:0003170)2.18794252
77Mesomelia (HP:0003027)2.17845798
78Abnormality of the lumbar spine (HP:0100712)2.15220554
79Broad phalanx (HP:0006009)2.03735471
80Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.99293425
81Radial bowing (HP:0002986)1.95660315
82Patent foramen ovale (HP:0001655)1.92894892
83Abnormality of the frontal sinuses (HP:0002687)1.90155592
84Abnormality of the odontoid process (HP:0003310)1.88226334
85Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.87845878
86Ulnar bowing (HP:0003031)1.87706573
87Abnormality of the 2nd finger (HP:0004100)1.87425364
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86952419
89Broad long bones (HP:0005622)1.85650123
90Hypoplastic ilia (HP:0000946)1.81424644
91Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.81112480
92Genu valgum (HP:0002857)1.79252008
93Abnormality of the middle phalanges of the hand (HP:0009833)1.78501675
94Flared metaphyses (HP:0003015)1.76403487
95Short ribs (HP:0000773)1.74097988
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.72316015
97Hepatoblastoma (HP:0002884)1.66653627
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65852145
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65097537
100Relative macrocephaly (HP:0004482)1.64338567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.06564770
2STK245.77963563
3PRKG25.15182235
4STK38L4.96862101
5MAP3K34.89320154
6NME14.24862342
7MST43.45593851
8ERBB32.92100977
9PLK21.87918221
10TAOK11.84799900
11TRPM71.77320566
12STK31.64937834
13TXK1.60212791
14NME21.54117841
15EPHA21.52399511
16PIK3CA1.39507976
17MAP2K31.38557295
18CAMKK21.33340521
19MAPK71.24166929
20PDK21.22259258
21PIM21.19160691
22NUAK11.15283296
23WNK41.14667612
24MAPK121.11686461
25EPHA41.08834825
26CDK91.00208739
27KSR10.99564194
28STK100.98668126
29TEC0.98499707
30NEK60.98449398
31BRD40.95393476
32TRIB30.94801149
33EIF2AK30.91766422
34DYRK1A0.87218273
35TAOK20.81912716
36SIK10.80861689
37MARK30.80459701
38ROCK10.79338423
39PIM10.74917381
40PAK30.64016935
41MKNK20.63431390
42MAPK40.63383823
43GRK60.63047003
44PRKG10.62766929
45LIMK10.59978161
46BMPR20.59799273
47LATS10.59219115
48SIK30.59070098
49BCR0.58370742
50MUSK0.57715106
51JAK30.54626121
52PRKACG0.49328131
53GSK3A0.48654352
54MAP4K10.48277037
55STK390.47534813
56PRKCH0.47477939
57TGFBR10.46475507
58MKNK10.44496398
59PDK10.43938132
60CSK0.40353369
61MST1R0.38046227
62PTK2B0.37933871
63ITK0.37184655
64JAK10.36333052
65MAP2K10.33052060
66MAPK100.32898712
67FGFR30.32686789
68CAMKK10.32279723
69PDGFRB0.31607783
70PRKCQ0.31335597
71MELK0.31140458
72CAMK2D0.28657573
73MAPK30.27478549
74TGFBR20.27279367
75RPS6KA40.26127894
76RPS6KB10.24615818
77IGF1R0.24044287
78BMPR1B0.23045501
79MET0.22983760
80PRKCD0.21438497
81MAP3K110.21124471
82ABL10.19682921
83TESK10.19420996
84PRKD30.19242015
85SGK10.19171720
86LCK0.18794569
87CSNK1A1L0.18508431
88IKBKB0.17656863
89PRKACA0.17084915
90TBK10.17015545
91HCK0.15485223
92INSR0.14090335
93MAP3K50.13752782
94EGFR0.13232525
95PRKCA0.11762202
96LYN0.11248032
97MAPK90.11028782
98PBK0.10611029
99MAPK10.10272834
100PAK60.09847398

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005326.73262349
2ECM-receptor interaction_Homo sapiens_hsa045125.93200444
3Protein digestion and absorption_Homo sapiens_hsa049745.63178351
4Steroid biosynthesis_Homo sapiens_hsa001003.53370675
5Sphingolipid metabolism_Homo sapiens_hsa006002.81109193
6Olfactory transduction_Homo sapiens_hsa047402.56611965
7Other glycan degradation_Homo sapiens_hsa005112.38745547
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.30812476
9Focal adhesion_Homo sapiens_hsa045102.14364872
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08498136
11Sulfur metabolism_Homo sapiens_hsa009201.90587504
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81813961
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73650584
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.61131339
15Malaria_Homo sapiens_hsa051441.52876676
16Starch and sucrose metabolism_Homo sapiens_hsa005001.52858583
17T cell receptor signaling pathway_Homo sapiens_hsa046601.47470098
18Protein export_Homo sapiens_hsa030601.46718591
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46179286
20Folate biosynthesis_Homo sapiens_hsa007901.41411343
21TGF-beta signaling pathway_Homo sapiens_hsa043501.32324085
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21726931
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19588392
24Ovarian steroidogenesis_Homo sapiens_hsa049131.16417071
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16003208
26Proteoglycans in cancer_Homo sapiens_hsa052051.13914902
27B cell receptor signaling pathway_Homo sapiens_hsa046620.96056742
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94017283
29cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88859664
30Long-term depression_Homo sapiens_hsa047300.88116666
31Hematopoietic cell lineage_Homo sapiens_hsa046400.80957669
32Hippo signaling pathway_Homo sapiens_hsa043900.77400779
33Platelet activation_Homo sapiens_hsa046110.76996755
34Osteoclast differentiation_Homo sapiens_hsa043800.76900671
35Oxytocin signaling pathway_Homo sapiens_hsa049210.75363322
36Salivary secretion_Homo sapiens_hsa049700.75160395
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74149622
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72517520
39Circadian entrainment_Homo sapiens_hsa047130.69310184
40Wnt signaling pathway_Homo sapiens_hsa043100.65358283
41Arginine and proline metabolism_Homo sapiens_hsa003300.65185442
42Hepatitis B_Homo sapiens_hsa051610.64478293
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63419316
44Thyroid cancer_Homo sapiens_hsa052160.62853208
45Phagosome_Homo sapiens_hsa041450.62049853
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61295437
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.60351300
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59748817
49Hedgehog signaling pathway_Homo sapiens_hsa043400.59494632
50VEGF signaling pathway_Homo sapiens_hsa043700.58169309
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56648556
52Gap junction_Homo sapiens_hsa045400.54451433
53Primary immunodeficiency_Homo sapiens_hsa053400.51046947
54Basal cell carcinoma_Homo sapiens_hsa052170.50874790
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49588941
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.49292908
57HTLV-I infection_Homo sapiens_hsa051660.48894074
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48113832
59Melanogenesis_Homo sapiens_hsa049160.46440481
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46171934
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45700434
62Lysine degradation_Homo sapiens_hsa003100.44705904
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44116346
64Colorectal cancer_Homo sapiens_hsa052100.41998372
65Galactose metabolism_Homo sapiens_hsa000520.40068258
66Vibrio cholerae infection_Homo sapiens_hsa051100.39772495
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37287310
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37105119
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36746937
70Cholinergic synapse_Homo sapiens_hsa047250.35935860
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35600610
72Dilated cardiomyopathy_Homo sapiens_hsa054140.35535484
73Axon guidance_Homo sapiens_hsa043600.34673192
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33153468
75cAMP signaling pathway_Homo sapiens_hsa040240.32084075
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29370660
77Glioma_Homo sapiens_hsa052140.28957663
78ErbB signaling pathway_Homo sapiens_hsa040120.28797773
79Apoptosis_Homo sapiens_hsa042100.28516237
80N-Glycan biosynthesis_Homo sapiens_hsa005100.28436037
81Dorso-ventral axis formation_Homo sapiens_hsa043200.27927480
82Long-term potentiation_Homo sapiens_hsa047200.26830669
83Amphetamine addiction_Homo sapiens_hsa050310.25842842
84Renal cell carcinoma_Homo sapiens_hsa052110.24869485
85Thyroid hormone synthesis_Homo sapiens_hsa049180.23484008
86HIF-1 signaling pathway_Homo sapiens_hsa040660.23360946
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22473962
88GnRH signaling pathway_Homo sapiens_hsa049120.22422307
89Prostate cancer_Homo sapiens_hsa052150.22066569
90MAPK signaling pathway_Homo sapiens_hsa040100.21433897
91Rap1 signaling pathway_Homo sapiens_hsa040150.21290337
92Arginine biosynthesis_Homo sapiens_hsa002200.19325852
93Acute myeloid leukemia_Homo sapiens_hsa052210.19039718
94Estrogen signaling pathway_Homo sapiens_hsa049150.18679977
95Selenocompound metabolism_Homo sapiens_hsa004500.18612248
96Measles_Homo sapiens_hsa051620.17748628
97Chemokine signaling pathway_Homo sapiens_hsa040620.14477623
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14418182
99Bile secretion_Homo sapiens_hsa049760.14279854
100Ras signaling pathway_Homo sapiens_hsa040140.14246963

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