TRDJ3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)9.46110055
2cytidine deamination (GO:0009972)9.46110055
3cytidine metabolic process (GO:0046087)9.46110055
4eosinophil chemotaxis (GO:0048245)8.93476517
5negative regulation by host of viral transcription (GO:0043922)8.55062183
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.35651633
7eosinophil migration (GO:0072677)8.06647933
8DNA deamination (GO:0045006)7.85704127
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.04661220
10regulation of chronic inflammatory response (GO:0002676)6.77140530
11regulation of regulatory T cell differentiation (GO:0045589)6.75351850
12positive regulation of natural killer cell mediated immunity (GO:0002717)6.49865492
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.48775522
14positive thymic T cell selection (GO:0045059)6.45066999
15regulation of activation of Janus kinase activity (GO:0010533)6.43054195
16positive regulation of interleukin-8 secretion (GO:2000484)6.40509374
17macrophage chemotaxis (GO:0048246)6.37976306
18regulation of lymphocyte chemotaxis (GO:1901623)6.36814098
19negative regulation of T cell apoptotic process (GO:0070233)6.27846465
20regulation of chemokine-mediated signaling pathway (GO:0070099)5.78370082
21positive T cell selection (GO:0043368)5.76179391
22positive regulation of T cell apoptotic process (GO:0070234)5.70819644
23positive regulation of monocyte chemotaxis (GO:0090026)5.62527061
24regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.47769911
25regulation of natural killer cell mediated immunity (GO:0002715)5.47769911
26membrane raft organization (GO:0031579)5.37148774
27regulation of mononuclear cell migration (GO:0071675)5.35454666
28positive regulation of T cell chemotaxis (GO:0010820)5.21416155
29regulation of T cell chemotaxis (GO:0010819)5.21416155
30positive regulation of translational initiation (GO:0045948)5.04799525
31positive regulation of gamma-delta T cell activation (GO:0046645)5.04463054
32response to interleukin-15 (GO:0070672)5.04258472
33cellular response to interleukin-15 (GO:0071350)4.87128660
34modulation by host of symbiont transcription (GO:0052472)4.76989881
35modulation by host of viral transcription (GO:0043921)4.76989881
36regulation of macrophage chemotaxis (GO:0010758)4.76443208
37positive regulation of lymphocyte migration (GO:2000403)4.74908549
38negative regulation of viral transcription (GO:0032897)4.70524328
39localization within membrane (GO:0051668)4.65601271
40positive regulation of lymphocyte apoptotic process (GO:0070230)4.64982160
41positive regulation of calcium-mediated signaling (GO:0050850)4.59072127
42dendritic cell chemotaxis (GO:0002407)4.59030592
43modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.52069282
44regulation of gamma-delta T cell differentiation (GO:0045586)4.47367834
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.45407128
46monocyte chemotaxis (GO:0002548)4.43707408
47regulation of interleukin-8 secretion (GO:2000482)4.33042114
48negative regulation of lymphocyte apoptotic process (GO:0070229)4.24572553
49regulation of interleukin-2 biosynthetic process (GO:0045076)4.21848220
50thymic T cell selection (GO:0045061)4.15368823
51regulation of T cell apoptotic process (GO:0070232)4.08496847
52positive regulation of cell killing (GO:0031343)4.03484824
53negative regulation of viral genome replication (GO:0045071)3.98817335
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91794320
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.86650068
56regulation of interleukin-12 biosynthetic process (GO:0045075)3.85582546
57granulocyte activation (GO:0036230)3.80711505
58positive regulation of leukocyte apoptotic process (GO:2000108)3.75379745
59regulation of monocyte chemotaxis (GO:0090025)3.74842457
60regulation of gamma-delta T cell activation (GO:0046643)3.73709634
61negative regulation of B cell proliferation (GO:0030889)3.69661990
62pyrimidine nucleoside catabolic process (GO:0046135)3.68803785
63T cell selection (GO:0045058)3.65434407
64sarcoplasmic reticulum calcium ion transport (GO:0070296)3.65358111
65establishment of protein localization to mitochondrial membrane (GO:0090151)3.64882533
66activated T cell proliferation (GO:0050798)3.64497760
67dendritic cell migration (GO:0036336)3.64441156
68regulation of homotypic cell-cell adhesion (GO:0034110)3.64361983
69regulation of lymphocyte migration (GO:2000401)3.60621849
70regulation of cell killing (GO:0031341)3.60421202
71T cell migration (GO:0072678)3.59850315
72regulation of T cell tolerance induction (GO:0002664)3.59409191
73positive regulation of tolerance induction (GO:0002645)3.57364085
74DNA demethylation (GO:0080111)3.57134755
75T cell costimulation (GO:0031295)3.56665631
76lymphocyte costimulation (GO:0031294)3.52208729
77regulation of calcium-mediated signaling (GO:0050848)3.42472546
78Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40116728
79diterpenoid biosynthetic process (GO:0016102)3.31869143
80positive regulation of cell adhesion mediated by integrin (GO:0033630)3.30578482
81negative regulation of B cell activation (GO:0050869)3.24928115
82nucleoside diphosphate catabolic process (GO:0009134)3.24837414
83regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24251047
84modification by host of symbiont morphology or physiology (GO:0051851)3.22481493
85positive regulation of T cell migration (GO:2000406)3.14290746
86DNA dealkylation (GO:0035510)3.13175952
87negative regulation of T cell activation (GO:0050868)3.11709739
88negative regulation of leukocyte apoptotic process (GO:2000107)3.10059629
89regulation of lymphocyte apoptotic process (GO:0070228)3.08675767
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07683026
91negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.07126948
92cytolysis (GO:0019835)3.07015593
93positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.02150663
94negative regulation of T cell differentiation (GO:0045581)3.01388986
95positive regulation of smooth muscle cell migration (GO:0014911)2.98858728
96negative regulation of T cell receptor signaling pathway (GO:0050860)2.98533464
97negative regulation of viral process (GO:0048525)2.97402358
98interaction with symbiont (GO:0051702)2.96235235
99negative regulation of thymocyte apoptotic process (GO:0070244)2.96065849
100histone mRNA catabolic process (GO:0071044)2.95382735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.81998678
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.42847052
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.39275090
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30331347
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.09174679
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83274620
7STAT4_19710469_ChIP-ChIP_TH1__Mouse2.75708720
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73323112
9MYB_26560356_Chip-Seq_TH2_Human2.72894537
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.48557971
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35744417
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35223646
13RUNX_20019798_ChIP-Seq_JUKART_Human2.30275858
14GATA3_27048872_Chip-Seq_THYMUS_Human2.27198682
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12301459
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11033298
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10623536
18MAF_26560356_Chip-Seq_TH2_Human2.09707892
19UTX_26944678_Chip-Seq_JUKART_Human2.01768497
20BP1_19119308_ChIP-ChIP_Hs578T_Human13.7292161
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93306783
22MYB_26560356_Chip-Seq_TH1_Human1.93101234
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82109747
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79072909
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78607018
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70399247
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67312158
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67235061
29MAF_26560356_Chip-Seq_TH1_Human1.64519127
30GATA3_26560356_Chip-Seq_TH2_Human1.57221377
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50582572
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45305715
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44340061
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.41580977
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33585689
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.31344109
37VDR_22108803_ChIP-Seq_LS180_Human1.28847328
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28440393
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26044601
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24238003
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15467647
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.13109245
43SPI1_23547873_ChIP-Seq_NB4_Human1.10958735
44HTT_18923047_ChIP-ChIP_STHdh_Human1.10175406
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07360986
46GATA3_26560356_Chip-Seq_TH1_Human1.06840880
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.06273192
48TAF2_19829295_ChIP-Seq_ESCs_Human1.04651131
49STAT1_20625510_ChIP-Seq_HELA_Human1.01468968
50CIITA_25753668_ChIP-Seq_RAJI_Human1.00871643
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97799491
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96901692
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94845601
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93372490
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93316329
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92234187
57TP53_22573176_ChIP-Seq_HFKS_Human0.91976221
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89828261
59POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89175149
60VDR_23849224_ChIP-Seq_CD4+_Human0.88388264
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88209110
62FOXP3_21729870_ChIP-Seq_TREG_Human0.87756897
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87107134
64SA1_27219007_Chip-Seq_Bcells_Human0.85606526
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85372425
66EST1_17652178_ChIP-ChIP_JURKAT_Human0.85372190
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85263907
68YY1_22570637_ChIP-Seq_MALME-3M_Human0.83257789
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79787571
70GABP_17652178_ChIP-ChIP_JURKAT_Human0.79724581
71P300_27268052_Chip-Seq_Bcells_Human0.78786695
72GATA6_21074721_ChIP-Seq_CACO-2_Human0.77935554
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76379317
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74786047
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72651863
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72233949
77TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.71828310
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.71224867
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.71171627
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69132427
81NANOG_20526341_ChIP-Seq_ESCs_Human0.66671109
82CEBPB_22108803_ChIP-Seq_LS180_Human0.65675340
83SCL_19346495_ChIP-Seq_HPC-7_Human0.65458384
84DCP1A_22483619_ChIP-Seq_HELA_Human0.65185093
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64026544
86RBPJ_21746931_ChIP-Seq_IB4_Human0.63806377
87BCAT_22108803_ChIP-Seq_LS180_Human0.63485596
88SOX2_19829295_ChIP-Seq_ESCs_Human0.62804659
89NANOG_19829295_ChIP-Seq_ESCs_Human0.62804659
90AR_21572438_ChIP-Seq_LNCaP_Human0.62199040
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.62004344
92CTCF_18555785_Chip-Seq_ESCs_Mouse0.61453780
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.60405406
94CTCF_20526341_ChIP-Seq_ESCs_Human0.60083167
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.59854905
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.59251023
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.57766816
98CTCF_21964334_Chip-Seq_Bcells_Human0.57203844
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.56937278
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.56844147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.53419641
2MP0006082_CNS_inflammation4.12136714
3MP0003763_abnormal_thymus_physiology3.92655198
4MP0002163_abnormal_gland_morphology2.95835409
5MP0009785_altered_susceptibility_to2.95622777
6MP0002148_abnormal_hypersensitivity_rea2.83148195
7MP0009333_abnormal_splenocyte_physiolog2.82306272
8MP0001873_stomach_inflammation2.78286932
9MP0001800_abnormal_humoral_immune2.78096512
10MP0005000_abnormal_immune_tolerance2.73839883
11MP0002723_abnormal_immune_serum2.60583704
12MP0001835_abnormal_antigen_presentation2.60013347
13MP0003866_abnormal_defecation2.54250219
14MP0002420_abnormal_adaptive_immunity2.41158702
15MP0001819_abnormal_immune_cell2.34179278
16MP0010155_abnormal_intestine_physiology2.33279170
17MP0002405_respiratory_system_inflammati2.23835250
18MP0005025_abnormal_response_to2.23644797
19MP0005377_hearing/vestibular/ear_phenot2.18763624
20MP0003878_abnormal_ear_physiology2.18763624
21MP0002398_abnormal_bone_marrow2.18349240
22MP0005387_immune_system_phenotype2.09601851
23MP0001790_abnormal_immune_system2.09601851
24MP0000716_abnormal_immune_system2.00009877
25MP0002933_joint_inflammation1.99966899
26MP0002722_abnormal_immune_system1.99094168
27MP0002452_abnormal_antigen_presenting1.96367445
28MP0005379_endocrine/exocrine_gland_phen1.88414171
29MP0005464_abnormal_platelet_physiology1.87471719
30MP0010307_abnormal_tumor_latency1.86254809
31MP0000703_abnormal_thymus_morphology1.81930003
32MP0000689_abnormal_spleen_morphology1.81764814
33MP0003786_premature_aging1.81410291
34MP0005310_abnormal_salivary_gland1.66998980
35MP0001661_extended_life_span1.64390046
36MP0002138_abnormal_hepatobiliary_system1.59216480
37MP0002429_abnormal_blood_cell1.57886117
38MP0004145_abnormal_muscle_electrophysio1.57249674
39MP0002396_abnormal_hematopoietic_system1.56483184
40MP0001845_abnormal_inflammatory_respons1.55577702
41MP0005075_abnormal_melanosome_morpholog1.54534351
42MP0003075_altered_response_to1.54274607
43MP0001188_hyperpigmentation1.53052083
44MP0002419_abnormal_innate_immunity1.50198070
45MP0004381_abnormal_hair_follicle1.38110974
46MP0000685_abnormal_immune_system1.34871474
47MP0003448_altered_tumor_morphology1.31945495
48MP0004185_abnormal_adipocyte_glucose1.31341679
49MP0002877_abnormal_melanocyte_morpholog1.26539814
50MP0008469_abnormal_protein_level1.23280027
51MP0003045_fibrosis1.22199810
52MP0001853_heart_inflammation1.22197287
53MP0000372_irregular_coat_pigmentation1.20379047
54MP0004147_increased_porphyrin_level1.16102221
55MP0005670_abnormal_white_adipose1.10673318
56MP0000858_altered_metastatic_potential1.08457416
57MP0000569_abnormal_digit_pigmentation1.07607682
58MP0005174_abnormal_tail_pigmentation1.02935377
59MP0002909_abnormal_adrenal_gland1.01156597
60MP0004947_skin_inflammation0.96634191
61MP0003172_abnormal_lysosome_physiology0.96605870
62MP0001984_abnormal_olfaction0.96297983
63MP0004134_abnormal_chest_morphology0.96173259
64MP0001485_abnormal_pinna_reflex0.93879610
65MP0000343_altered_response_to0.93562176
66MP0008873_increased_physiological_sensi0.93502853
67MP0001502_abnormal_circadian_rhythm0.91399831
68MP0003436_decreased_susceptibility_to0.87077488
69MP0002166_altered_tumor_susceptibility0.87009008
70MP0005645_abnormal_hypothalamus_physiol0.86499858
71MP0003183_abnormal_peptide_metabolism0.86190645
72MP0009763_increased_sensitivity_to0.85966475
73MP0009764_decreased_sensitivity_to0.85772525
74MP0002876_abnormal_thyroid_physiology0.85541119
75MP0000920_abnormal_myelination0.85274229
76MP0002234_abnormal_pharynx_morphology0.80767482
77MP0001905_abnormal_dopamine_level0.79036462
78MP0009765_abnormal_xenobiotic_induced0.74785357
79MP0002638_abnormal_pupillary_reflex0.74627577
80MP0002733_abnormal_thermal_nociception0.70412817
81MP0008007_abnormal_cellular_replicative0.70323986
82MP0002693_abnormal_pancreas_physiology0.66237674
83MP0003959_abnormal_lean_body0.64954578
84MP0008770_decreased_survivor_rate0.63929342
85MP0003111_abnormal_nucleus_morphology0.63454468
86MP0005166_decreased_susceptibility_to0.62207206
87MP0002006_tumorigenesis0.61614684
88MP0002019_abnormal_tumor_incidence0.61268666
89MP0001727_abnormal_embryo_implantation0.57314502
90MP0005319_abnormal_enzyme/_coenzyme0.55873446
91MP0006035_abnormal_mitochondrial_morpho0.55815272
92MP0001348_abnormal_lacrimal_gland0.55024435
93MP0000015_abnormal_ear_pigmentation0.54853107
94MP0001243_abnormal_dermal_layer0.52791835
95MP0009643_abnormal_urine_homeostasis0.50161746
96MP0002083_premature_death0.48547408
97MP0003724_increased_susceptibility_to0.48100875
98MP0001346_abnormal_lacrimal_gland0.47843150
99MP0002009_preneoplasia0.47341804
100MP0005666_abnormal_adipose_tissue0.46158328

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)7.10915301
2T lymphocytopenia (HP:0005403)6.66032347
3Autoimmune hemolytic anemia (HP:0001890)5.60234035
4Hypoproteinemia (HP:0003075)5.40681375
5Increased IgM level (HP:0003496)5.12908581
6Abnormal delayed hypersensitivity skin test (HP:0002963)5.03311759
7Abnormality of T cells (HP:0002843)4.42681675
8Severe combined immunodeficiency (HP:0004430)4.34034528
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.32728097
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.32728097
11Abnormality of the prostate (HP:0008775)4.24491174
12Autoimmune thrombocytopenia (HP:0001973)4.18097627
13Abnormality of eosinophils (HP:0001879)3.96267480
14IgG deficiency (HP:0004315)3.82476197
15Meningitis (HP:0001287)3.76751844
163-Methylglutaconic aciduria (HP:0003535)3.62620184
17Recurrent bronchitis (HP:0002837)3.56341624
18Ureteral stenosis (HP:0000071)3.52417672
19Obstructive lung disease (HP:0006536)3.51118350
20Chronic obstructive pulmonary disease (HP:0006510)3.51118350
21Hypoplasia of the thymus (HP:0000778)3.51074372
22Thyroiditis (HP:0100646)3.50866131
23Chronic diarrhea (HP:0002028)3.48321984
24Combined immunodeficiency (HP:0005387)3.47496535
25Eosinophilia (HP:0001880)3.45573498
26Granulocytopenia (HP:0001913)3.36642332
27Gangrene (HP:0100758)3.34334580
28Hemoptysis (HP:0002105)3.31617467
29Ureteral obstruction (HP:0006000)3.21351571
30Chest pain (HP:0100749)3.21215773
31J-shaped sella turcica (HP:0002680)3.17942966
32Zonular cataract (HP:0010920)3.17754469
33Abnormality of B cell number (HP:0010975)3.15794937
34Recurrent cutaneous fungal infections (HP:0011370)3.15516280
35Chronic mucocutaneous candidiasis (HP:0002728)3.15516280
36Abnormal biliary tract physiology (HP:0012439)3.05509530
37Bile duct proliferation (HP:0001408)3.05509530
38Vasculitis (HP:0002633)2.93287739
39Hemiplegia (HP:0002301)2.81784855
40Encephalitis (HP:0002383)2.80020103
41Abnormality of cells of the lymphoid lineage (HP:0012140)2.79090350
42Leukocytosis (HP:0001974)2.78418688
43Panhypogammaglobulinemia (HP:0003139)2.76675983
44Agammaglobulinemia (HP:0004432)2.75722332
45Recurrent fungal infections (HP:0002841)2.71530322
46Pulmonary infiltrates (HP:0002113)2.70060169
47Abnormality of male internal genitalia (HP:0000022)2.67642031
48Carpal bone hypoplasia (HP:0001498)2.67384972
49Stomach cancer (HP:0012126)2.61838216
50Abnormality of T cell physiology (HP:0011840)2.60253165
51Increased intramyocellular lipid droplets (HP:0012240)2.58224613
52Focal motor seizures (HP:0011153)2.58077959
53Abnormality of the alveolar ridges (HP:0006477)2.57982926
54Abnormality of macrophages (HP:0004311)2.55890666
55Abnormality of the pleura (HP:0002103)2.47579566
56Abnormal albumin level (HP:0012116)2.45963305
57Hypoalbuminemia (HP:0003073)2.45963305
58Visual hallucinations (HP:0002367)2.45805741
59Tetraplegia (HP:0002445)2.45230500
60Gastrointestinal infarctions (HP:0005244)2.44154876
61Recurrent viral infections (HP:0004429)2.43327193
62Pustule (HP:0200039)2.43163909
63Lymphopenia (HP:0001888)2.41445645
64Recurrent skin infections (HP:0001581)2.37526678
65Myositis (HP:0100614)2.35069357
66Pulmonary embolism (HP:0002204)2.31429106
67Recurrent bacterial skin infections (HP:0005406)2.28515245
68Recurrent otitis media (HP:0000403)2.27804081
69Pulmonary fibrosis (HP:0002206)2.25993365
70Retrobulbar optic neuritis (HP:0100654)2.23020266
71Optic neuritis (HP:0100653)2.23020266
72Albinism (HP:0001022)2.22356659
73Recurrent abscess formation (HP:0002722)2.21506634
74Amaurosis fugax (HP:0100576)2.16648068
75Aplastic anemia (HP:0001915)2.16157667
76Lymphoma (HP:0002665)2.09703456
77Flat capital femoral epiphysis (HP:0003370)2.07443878
78Acute necrotizing encephalopathy (HP:0006965)2.07220458
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06235722
80Increased muscle lipid content (HP:0009058)2.02458970
81Hypergammaglobulinemia (HP:0010702)2.01559148
82Joint swelling (HP:0001386)2.01299115
83Severe visual impairment (HP:0001141)1.99246072
84Pancreatic cysts (HP:0001737)1.97416226
85Abnormality of midbrain morphology (HP:0002418)1.97100973
86Molar tooth sign on MRI (HP:0002419)1.97100973
87Bronchitis (HP:0012387)1.95879596
88Abnormal mitochondria in muscle tissue (HP:0008316)1.93350231
89Palpitations (HP:0001962)1.92912325
90Abnormality of the pericardium (HP:0001697)1.91423963
91Skin rash (HP:0000988)1.90070172
92Orchitis (HP:0100796)1.89755767
93Melanoma (HP:0002861)1.86785063
94Abnormality of the common coagulation pathway (HP:0010990)1.85437386
95Polyneuropathy (HP:0001271)1.85430799
96Abnormality of DNA repair (HP:0003254)1.81968382
97Thrombophlebitis (HP:0004418)1.81613254
98Glomerulopathy (HP:0100820)1.76872291
99Periorbital edema (HP:0100539)1.75848805
100Facial edema (HP:0000282)1.74818142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.84533675
2KDR4.31824223
3BUB13.45693483
4GRK73.33833981
5TRIM283.16295150
6ZAK3.02040168
7MAP4K13.02021040
8ADRBK22.51302104
9ITK2.46101773
10PRKCQ2.33691233
11FES2.06762565
12JAK32.00661875
13MAP3K121.79404545
14ZAP701.76693550
15SYK1.65783494
16CSK1.59390622
17BCKDK1.59033051
18LCK1.50777607
19PIK3CA1.50462726
20RIPK41.50116433
21PIK3CG1.31997244
22STK161.30723230
23VRK21.20072477
24MYLK1.17699856
25TYRO31.13549882
26TESK21.04945354
27WNK41.04527632
28TIE11.02319575
29NUAK10.98458862
30JAK20.95679683
31MAP3K50.94489408
32DAPK10.91291794
33TBK10.91144645
34SRPK10.89360572
35LYN0.87765360
36BTK0.86162561
37IKBKE0.84308404
38MELK0.83136604
39BCR0.83057683
40TEC0.82992469
41MST40.81624718
42TGFBR20.77564606
43FYN0.75951143
44CSF1R0.70810807
45PDGFRB0.69724031
46BMPR1B0.67324933
47PNCK0.65732377
48MAP2K60.63541360
49MAPK110.62499904
50EIF2AK30.58805345
51MATK0.58756182
52PIM10.55536927
53CLK10.53585850
54PDK10.53146785
55PIM20.52793558
56INSR0.52767444
57NEK10.52378589
58TAOK30.51450999
59JAK10.51242604
60BLK0.51092795
61STK100.49410405
62GRK10.48930745
63BMPR20.47229835
64MAP3K110.46693213
65MAPKAPK20.46587083
66NTRK10.45687049
67MAPKAPK30.43686490
68IGF1R0.43637718
69ADRBK10.38544420
70VRK10.35836919
71ARAF0.35767233
72ROCK10.33901731
73EIF2AK20.32062964
74CAMK2D0.30753226
75IKBKB0.28595549
76PRKCA0.28211344
77MAPK120.27847347
78MAPK30.26493920
79PDPK10.25769961
80SMG10.25041754
81TYK20.24413742
82CSNK1A10.24305519
83CAMK2A0.23063628
84ATR0.22859602
85HCK0.21569661
86CHEK20.21553875
87DYRK1B0.19284373
88PRKACA0.17890415
89IRAK40.17445321
90GRK50.17077969
91OBSCN0.16680356
92RET0.16670438
93LRRK20.16059735
94TTK0.15825961
95MAPKAPK50.15667843
96DAPK30.15438405
97INSRR0.14593560
98RAF10.14427456
99DYRK20.14056204
100ABL20.13950061

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.57111522
2Autoimmune thyroid disease_Homo sapiens_hsa053204.45556791
3Graft-versus-host disease_Homo sapiens_hsa053324.24808034
4Allograft rejection_Homo sapiens_hsa053304.01864171
5Rheumatoid arthritis_Homo sapiens_hsa053233.66302730
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.37909436
7Type I diabetes mellitus_Homo sapiens_hsa049403.26189675
8Hematopoietic cell lineage_Homo sapiens_hsa046403.06527813
9T cell receptor signaling pathway_Homo sapiens_hsa046602.77830562
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.77777431
11Antigen processing and presentation_Homo sapiens_hsa046122.71604106
12Proteasome_Homo sapiens_hsa030502.57378225
13Salmonella infection_Homo sapiens_hsa051322.53489952
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39496774
15Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.33135298
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.91140663
17Measles_Homo sapiens_hsa051621.85769957
18Asthma_Homo sapiens_hsa053101.84539893
19Viral myocarditis_Homo sapiens_hsa054161.81529375
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70465435
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66391410
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.54404478
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45082688
24Chemokine signaling pathway_Homo sapiens_hsa040621.40395515
25Prion diseases_Homo sapiens_hsa050201.39993851
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29916875
27Oxidative phosphorylation_Homo sapiens_hsa001901.24168664
28Parkinsons disease_Homo sapiens_hsa050121.18552955
29Staphylococcus aureus infection_Homo sapiens_hsa051501.10870778
30Leishmaniasis_Homo sapiens_hsa051401.03716924
31HTLV-I infection_Homo sapiens_hsa051661.00492322
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92942785
33Herpes simplex infection_Homo sapiens_hsa051680.92013795
34RNA polymerase_Homo sapiens_hsa030200.89509164
35Apoptosis_Homo sapiens_hsa042100.86410479
36Protein export_Homo sapiens_hsa030600.83178501
37Malaria_Homo sapiens_hsa051440.81614156
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81199680
39TNF signaling pathway_Homo sapiens_hsa046680.77594823
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75004147
41Epstein-Barr virus infection_Homo sapiens_hsa051690.74434567
42Osteoclast differentiation_Homo sapiens_hsa043800.74320803
43Influenza A_Homo sapiens_hsa051640.66720964
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66537474
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64567842
46Alzheimers disease_Homo sapiens_hsa050100.62882265
47Shigellosis_Homo sapiens_hsa051310.61532710
48Linoleic acid metabolism_Homo sapiens_hsa005910.61340278
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60982639
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.58341971
51Systemic lupus erythematosus_Homo sapiens_hsa053220.57934966
52African trypanosomiasis_Homo sapiens_hsa051430.53992230
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50592062
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50277282
55Mismatch repair_Homo sapiens_hsa034300.40767977
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.38400175
57Cardiac muscle contraction_Homo sapiens_hsa042600.36944577
58Caffeine metabolism_Homo sapiens_hsa002320.36462824
59Huntingtons disease_Homo sapiens_hsa050160.34236036
60Collecting duct acid secretion_Homo sapiens_hsa049660.33119134
61Tuberculosis_Homo sapiens_hsa051520.32462977
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31959496
63Toxoplasmosis_Homo sapiens_hsa051450.30432991
64Phagosome_Homo sapiens_hsa041450.28520747
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28399702
66Nucleotide excision repair_Homo sapiens_hsa034200.27986477
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27489811
68B cell receptor signaling pathway_Homo sapiens_hsa046620.26348469
69Legionellosis_Homo sapiens_hsa051340.25997015
70Ether lipid metabolism_Homo sapiens_hsa005650.22369487
71p53 signaling pathway_Homo sapiens_hsa041150.19744042
72Peroxisome_Homo sapiens_hsa041460.19208604
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18192757
74Dorso-ventral axis formation_Homo sapiens_hsa043200.17197298
75Pyrimidine metabolism_Homo sapiens_hsa002400.16547483
76Homologous recombination_Homo sapiens_hsa034400.15518189
77Viral carcinogenesis_Homo sapiens_hsa052030.14347721
78DNA replication_Homo sapiens_hsa030300.14275094
79Endocytosis_Homo sapiens_hsa041440.13044029
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11443492
81Retinol metabolism_Homo sapiens_hsa008300.11126527
82Arachidonic acid metabolism_Homo sapiens_hsa005900.09813807
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09791203
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.09293327
85Lysosome_Homo sapiens_hsa041420.06741912
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06271622
87Butanoate metabolism_Homo sapiens_hsa006500.06131326
88Alcoholism_Homo sapiens_hsa050340.06109223
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.05503879
90One carbon pool by folate_Homo sapiens_hsa006700.05206980
91RNA degradation_Homo sapiens_hsa030180.04947941
92Purine metabolism_Homo sapiens_hsa002300.02075298
93Phototransduction_Homo sapiens_hsa047440.01822469
94Ras signaling pathway_Homo sapiens_hsa040140.00838721
95Chronic myeloid leukemia_Homo sapiens_hsa052200.00702506
96Type II diabetes mellitus_Homo sapiens_hsa049300.00345516
97Hepatitis B_Homo sapiens_hsa051610.00170663
98Platelet activation_Homo sapiens_hsa04611-0.0437903
99Pertussis_Homo sapiens_hsa05133-0.0395324
100Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0231495

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