

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 9.81015615 |
| 2 | negative thymic T cell selection (GO:0045060) | 8.90917867 |
| 3 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.49061778 |
| 4 | positive T cell selection (GO:0043368) | 8.07207568 |
| 5 | positive thymic T cell selection (GO:0045059) | 7.54686825 |
| 6 | thymic T cell selection (GO:0045061) | 7.52997018 |
| 7 | T cell selection (GO:0045058) | 7.30541098 |
| 8 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.24707066 |
| 9 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 7.23705529 |
| 10 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 7.23705529 |
| 11 | negative regulation of cell killing (GO:0031342) | 7.19694072 |
| 12 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 7.19694072 |
| 13 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.95499655 |
| 14 | regulation of T cell tolerance induction (GO:0002664) | 6.78896111 |
| 15 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.77007985 |
| 16 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.72773116 |
| 17 | interferon-gamma production (GO:0032609) | 6.48689039 |
| 18 | regulation of gamma-delta T cell activation (GO:0046643) | 6.48475484 |
| 19 | T cell receptor signaling pathway (GO:0050852) | 6.17550599 |
| 20 | activated T cell proliferation (GO:0050798) | 6.15430733 |
| 21 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.96580681 |
| 22 | T cell migration (GO:0072678) | 5.82818497 |
| 23 | response to interleukin-15 (GO:0070672) | 5.81294273 |
| 24 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.74336470 |
| 25 | T cell costimulation (GO:0031295) | 5.68090087 |
| 26 | cellular response to interleukin-15 (GO:0071350) | 5.65266565 |
| 27 | lymphocyte costimulation (GO:0031294) | 5.58412357 |
| 28 | positive regulation of tolerance induction (GO:0002645) | 5.56761954 |
| 29 | leukocyte aggregation (GO:0070486) | 5.50989090 |
| 30 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.98884891 |
| 31 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.86814323 |
| 32 | regulation of tolerance induction (GO:0002643) | 4.85342891 |
| 33 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.84959505 |
| 34 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.84470646 |
| 35 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 4.83355650 |
| 36 | negative regulation of T-helper cell differentiation (GO:0045623) | 4.83355650 |
| 37 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.82046933 |
| 38 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.82046933 |
| 39 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 4.80428142 |
| 40 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.71841649 |
| 41 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.68065474 |
| 42 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.68065474 |
| 43 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.58753655 |
| 44 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.54434055 |
| 45 | positive regulation of interleukin-2 production (GO:0032743) | 4.44378533 |
| 46 | mast cell activation (GO:0045576) | 4.37314898 |
| 47 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.11314911 |
| 48 | V(D)J recombination (GO:0033151) | 4.10715039 |
| 49 | positive regulation of isotype switching (GO:0045830) | 4.10654968 |
| 50 | T cell differentiation (GO:0030217) | 3.97812665 |
| 51 | negative regulation of T cell mediated immunity (GO:0002710) | 3.96725067 |
| 52 | signal complex assembly (GO:0007172) | 3.93045990 |
| 53 | regulation of B cell differentiation (GO:0045577) | 3.92341807 |
| 54 | regulation of isotype switching (GO:0045191) | 3.90220146 |
| 55 | positive regulation of B cell differentiation (GO:0045579) | 3.89608481 |
| 56 | regulation of regulatory T cell differentiation (GO:0045589) | 3.88495735 |
| 57 | regulation of defense response to virus by virus (GO:0050690) | 3.81789309 |
| 58 | alpha-beta T cell differentiation (GO:0046632) | 3.81411635 |
| 59 | alpha-beta T cell activation (GO:0046631) | 3.81404373 |
| 60 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.80877567 |
| 61 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.76366727 |
| 62 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.75900179 |
| 63 | negative regulation of adaptive immune response (GO:0002820) | 3.75656222 |
| 64 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.74475348 |
| 65 | positive regulation of immune response to tumor cell (GO:0002839) | 3.73599935 |
| 66 | regulation of immune response to tumor cell (GO:0002837) | 3.73599935 |
| 67 | regulation of response to tumor cell (GO:0002834) | 3.73599935 |
| 68 | positive regulation of response to tumor cell (GO:0002836) | 3.73599935 |
| 69 | T cell activation (GO:0042110) | 3.69050233 |
| 70 | Peyers patch development (GO:0048541) | 3.68532933 |
| 71 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.68532933 |
| 72 | positive regulation of B cell mediated immunity (GO:0002714) | 3.64812372 |
| 73 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.64812372 |
| 74 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.60745016 |
| 75 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.60353367 |
| 76 | sequestering of actin monomers (GO:0042989) | 3.60002281 |
| 77 | leukocyte cell-cell adhesion (GO:0007159) | 3.58261789 |
| 78 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.54401341 |
| 79 | response to interleukin-4 (GO:0070670) | 3.53767453 |
| 80 | positive regulation of DNA recombination (GO:0045911) | 3.52386464 |
| 81 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.51845747 |
| 82 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.49021487 |
| 83 | positive regulation of humoral immune response (GO:0002922) | 3.47512733 |
| 84 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.46621549 |
| 85 | heterotypic cell-cell adhesion (GO:0034113) | 3.44373545 |
| 86 | B cell receptor signaling pathway (GO:0050853) | 3.43937556 |
| 87 | ribosomal small subunit assembly (GO:0000028) | 3.43260889 |
| 88 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.41228098 |
| 89 | negative regulation of alpha-beta T cell activation (GO:0046636) | 3.40295110 |
| 90 | regulation of B cell mediated immunity (GO:0002712) | 3.38236931 |
| 91 | positive regulation of interleukin-4 production (GO:0032753) | 3.38122331 |
| 92 | T cell proliferation (GO:0042098) | 3.34522011 |
| 93 | regulation of alpha-beta T cell activation (GO:0046634) | 3.34373650 |
| 94 | mast cell activation involved in immune response (GO:0002279) | 3.32176458 |
| 95 | mast cell degranulation (GO:0043303) | 3.32176458 |
| 96 | viral transcription (GO:0019083) | 3.31055772 |
| 97 | regulation of interleukin-2 production (GO:0032663) | 3.30912478 |
| 98 | lymphocyte migration (GO:0072676) | 3.30326063 |
| 99 | cellular response to interleukin-4 (GO:0071353) | 3.28480528 |
| 100 | regulation of interleukin-4 production (GO:0032673) | 3.28462312 |
| 101 | positive regulation of cell killing (GO:0031343) | 3.28203093 |
| 102 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.27810406 |
| 103 | positive regulation of T cell activation (GO:0050870) | 3.22623903 |
| 104 | T cell homeostasis (GO:0043029) | 3.21902203 |
| 105 | T-helper cell differentiation (GO:0042093) | 3.21882983 |
| 106 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.21882983 |
| 107 | regulation of response to interferon-gamma (GO:0060330) | 3.21880606 |
| 108 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.20294461 |
| 109 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 3.19762090 |
| 110 | hepatocyte apoptotic process (GO:0097284) | 3.19368164 |
| 111 | regulation of cell killing (GO:0031341) | 3.19024429 |
| 112 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.16356292 |
| 113 | translational termination (GO:0006415) | 3.15038469 |
| 114 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.14347058 |
| 115 | regulation of immunoglobulin production (GO:0002637) | 3.13164749 |
| 116 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.13097204 |
| 117 | tolerance induction (GO:0002507) | 3.12063616 |
| 118 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 3.11401634 |
| 119 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.09030703 |
| 120 | positive regulation of granulocyte differentiation (GO:0030854) | 3.08961136 |
| 121 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.08373032 |
| 122 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.08373032 |
| 123 | modulation by symbiont of host immune response (GO:0052553) | 3.08373032 |
| 124 | positive regulation by symbiont of host defense response (GO:0052509) | 3.08373032 |
| 125 | modulation by symbiont of host defense response (GO:0052031) | 3.08373032 |
| 126 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.08373032 |
| 127 | T cell differentiation involved in immune response (GO:0002292) | 3.08319034 |
| 128 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.08319034 |
| 129 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.08319034 |
| 130 | negative regulation of interleukin-12 production (GO:0032695) | 3.07985130 |
| 131 | regulation of granulocyte differentiation (GO:0030852) | 3.07256991 |
| 132 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.06462609 |
| 133 | natural killer cell differentiation (GO:0001779) | 3.05923500 |
| 134 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.05724283 |
| 135 | positive regulation of immunoglobulin production (GO:0002639) | 3.05011754 |
| 136 | natural killer cell activation (GO:0030101) | 3.04695475 |
| 137 | cellular extravasation (GO:0045123) | 3.03878333 |
| 138 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.03875433 |
| 139 | type I interferon signaling pathway (GO:0060337) | 2.98851655 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.03570332 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.61883425 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.05332957 |
| 4 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.88983590 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 3.87571080 |
| 6 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.84295877 |
| 7 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.82084674 |
| 8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.54436669 |
| 9 | MYB_26560356_Chip-Seq_TH2_Human | 3.52486657 |
| 10 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.40619371 |
| 11 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.29020074 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.11457884 |
| 13 | MAF_26560356_Chip-Seq_TH1_Human | 3.04498992 |
| 14 | UTX_26944678_Chip-Seq_JUKART_Human | 2.99656737 |
| 15 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.96055747 |
| 16 | MYB_26560356_Chip-Seq_TH1_Human | 2.74482325 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.54177042 |
| 18 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.46890930 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.44457517 |
| 20 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.42941532 |
| 21 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.30612067 |
| 22 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.29173533 |
| 23 | MAF_26560356_Chip-Seq_TH2_Human | 2.27180716 |
| 24 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.19172533 |
| 25 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.18409312 |
| 26 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.14370467 |
| 27 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.11315743 |
| 28 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.93430500 |
| 29 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.90578949 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.86516611 |
| 31 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.82691936 |
| 32 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.82356630 |
| 33 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.81813731 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.74804123 |
| 35 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.73236963 |
| 36 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.71779653 |
| 37 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.71360714 |
| 38 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.70737087 |
| 39 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.62807513 |
| 40 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.60186215 |
| 41 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59403654 |
| 42 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.57267902 |
| 43 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.56474897 |
| 44 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.55610722 |
| 45 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.53418174 |
| 46 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.51429799 |
| 47 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.49163107 |
| 48 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.48236036 |
| 49 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.45356507 |
| 50 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.41873217 |
| 51 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40055656 |
| 52 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.39676066 |
| 53 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.36966154 |
| 54 | SPI1_23127762_ChIP-Seq_K562_Human | 1.36422170 |
| 55 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.35102079 |
| 56 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.31268619 |
| 57 | GATA1_22025678_ChIP-Seq_K562_Human | 1.30093797 |
| 58 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.30092793 |
| 59 | GATA3_26560356_Chip-Seq_TH2_Human | 1.28937998 |
| 60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26878468 |
| 61 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.21552083 |
| 62 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.17454201 |
| 63 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.17340986 |
| 64 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.13583307 |
| 65 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.12706554 |
| 66 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.10934347 |
| 67 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.09951890 |
| 68 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.08155087 |
| 69 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.06971116 |
| 70 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.04641163 |
| 71 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.02203242 |
| 72 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99939045 |
| 73 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.99362181 |
| 74 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.98630381 |
| 75 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98008288 |
| 76 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.97576089 |
| 77 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.97475828 |
| 78 | GATA3_26560356_Chip-Seq_TH1_Human | 0.97203504 |
| 79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.96798351 |
| 80 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.95773676 |
| 81 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95421256 |
| 82 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.94873462 |
| 83 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.94605205 |
| 84 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.94545648 |
| 85 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94025310 |
| 86 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.92647622 |
| 87 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.92646850 |
| 88 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92045877 |
| 89 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.91505428 |
| 90 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91494286 |
| 91 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91479284 |
| 92 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.90300754 |
| 93 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89243600 |
| 94 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86380586 |
| 95 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.84952575 |
| 96 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83096890 |
| 97 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.83072084 |
| 98 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.82517821 |
| 99 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.81326229 |
| 100 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.77349205 |
| 101 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.77158525 |
| 102 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.76727157 |
| 103 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.75728998 |
| 104 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.72954541 |
| 105 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.72667245 |
| 106 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.72560969 |
| 107 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.70887323 |
| 108 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.70754543 |
| 109 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.68667678 |
| 110 | GATA1_19941826_ChIP-Seq_K562_Human | 0.68614762 |
| 111 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.68231787 |
| 112 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.67305379 |
| 113 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.66884597 |
| 114 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.65701684 |
| 115 | FLI1_21867929_ChIP-Seq_CD8_Mouse | 0.64146892 |
| 116 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.62568689 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.77807407 |
| 2 | MP0005671_abnormal_response_to | 4.96129472 |
| 3 | MP0000685_abnormal_immune_system | 3.59556623 |
| 4 | MP0000703_abnormal_thymus_morphology | 3.36795894 |
| 5 | MP0009333_abnormal_splenocyte_physiolog | 3.34443637 |
| 6 | MP0002398_abnormal_bone_marrow | 3.16604701 |
| 7 | MP0001800_abnormal_humoral_immune | 3.11856756 |
| 8 | MP0002420_abnormal_adaptive_immunity | 3.04405344 |
| 9 | MP0002166_altered_tumor_susceptibility | 2.99642216 |
| 10 | MP0001819_abnormal_immune_cell | 2.98438076 |
| 11 | MP0005000_abnormal_immune_tolerance | 2.94519834 |
| 12 | MP0001835_abnormal_antigen_presentation | 2.90499665 |
| 13 | MP0002723_abnormal_immune_serum | 2.81373399 |
| 14 | MP0001790_abnormal_immune_system | 2.77456462 |
| 15 | MP0005387_immune_system_phenotype | 2.77456462 |
| 16 | MP0000716_abnormal_immune_system | 2.70673458 |
| 17 | MP0002405_respiratory_system_inflammati | 2.69707742 |
| 18 | MP0002722_abnormal_immune_system | 2.65096282 |
| 19 | MP0006082_CNS_inflammation | 2.53776165 |
| 20 | MP0002452_abnormal_antigen_presenting | 2.50050680 |
| 21 | MP0002006_tumorigenesis | 2.46089263 |
| 22 | MP0000689_abnormal_spleen_morphology | 2.39558216 |
| 23 | MP0005025_abnormal_response_to | 2.38549195 |
| 24 | MP0003724_increased_susceptibility_to | 2.34578734 |
| 25 | MP0009785_altered_susceptibility_to | 2.31966690 |
| 26 | MP0003866_abnormal_defecation | 2.23669502 |
| 27 | MP0003300_gastrointestinal_ulcer | 2.21645753 |
| 28 | MP0002429_abnormal_blood_cell | 2.17862630 |
| 29 | MP0004947_skin_inflammation | 2.14804916 |
| 30 | MP0003436_decreased_susceptibility_to | 2.13255410 |
| 31 | MP0002396_abnormal_hematopoietic_system | 2.12537328 |
| 32 | MP0002933_joint_inflammation | 2.07709634 |
| 33 | MP0010155_abnormal_intestine_physiology | 2.05146633 |
| 34 | MP0001873_stomach_inflammation | 2.01929167 |
| 35 | MP0002148_abnormal_hypersensitivity_rea | 1.83712005 |
| 36 | MP0000858_altered_metastatic_potential | 1.83532454 |
| 37 | MP0004381_abnormal_hair_follicle | 1.76027369 |
| 38 | MP0005464_abnormal_platelet_physiology | 1.72149646 |
| 39 | MP0003303_peritoneal_inflammation | 1.68943091 |
| 40 | MP0001845_abnormal_inflammatory_respons | 1.67584418 |
| 41 | MP0002419_abnormal_innate_immunity | 1.66855955 |
| 42 | MP0003448_altered_tumor_morphology | 1.48640733 |
| 43 | MP0005451_abnormal_body_composition | 1.47223319 |
| 44 | MP0004808_abnormal_hematopoietic_stem | 1.46800376 |
| 45 | MP0003183_abnormal_peptide_metabolism | 1.39432016 |
| 46 | MP0002132_abnormal_respiratory_system | 1.27768602 |
| 47 | MP0002138_abnormal_hepatobiliary_system | 1.19766757 |
| 48 | MP0005075_abnormal_melanosome_morpholog | 1.17205044 |
| 49 | MP0001853_heart_inflammation | 1.15946555 |
| 50 | MP0002019_abnormal_tumor_incidence | 1.14175339 |
| 51 | MP0000465_gastrointestinal_hemorrhage | 1.13578800 |
| 52 | MP0004510_myositis | 1.10424576 |
| 53 | MP0008961_abnormal_basal_metabolism | 1.04099891 |
| 54 | MP0000490_abnormal_crypts_of | 1.03756020 |
| 55 | MP0004957_abnormal_blastocyst_morpholog | 1.01623483 |
| 56 | MP0008469_abnormal_protein_level | 0.99132107 |
| 57 | MP0003045_fibrosis | 0.97272946 |
| 58 | MP0001533_abnormal_skeleton_physiology | 0.96568469 |
| 59 | MP0005310_abnormal_salivary_gland | 0.92402839 |
| 60 | MP0003828_pulmonary_edema | 0.90076711 |
| 61 | MP0002998_abnormal_bone_remodeling | 0.88796283 |
| 62 | MP0010352_gastrointestinal_tract_polyps | 0.88214579 |
| 63 | MP0008057_abnormal_DNA_replication | 0.88049826 |
| 64 | MP0005397_hematopoietic_system_phenotyp | 0.87853839 |
| 65 | MP0001545_abnormal_hematopoietic_system | 0.87853839 |
| 66 | MP0002009_preneoplasia | 0.85462296 |
| 67 | MP0008260_abnormal_autophagy | 0.84514173 |
| 68 | MP0008877_abnormal_DNA_methylation | 0.84484234 |
| 69 | MP0002277_abnormal_respiratory_mucosa | 0.84101223 |
| 70 | MP0005023_abnormal_wound_healing | 0.82552746 |
| 71 | MP0003787_abnormal_imprinting | 0.79167830 |
| 72 | MP0003077_abnormal_cell_cycle | 0.77536574 |
| 73 | MP0001243_abnormal_dermal_layer | 0.76356193 |
| 74 | MP0001851_eye_inflammation | 0.76044760 |
| 75 | MP0004185_abnormal_adipocyte_glucose | 0.76008810 |
| 76 | MP0008995_early_reproductive_senescence | 0.75294391 |
| 77 | MP0003172_abnormal_lysosome_physiology | 0.74904105 |
| 78 | MP0003195_calcinosis | 0.73951149 |
| 79 | MP0008007_abnormal_cellular_replicative | 0.71866842 |
| 80 | MP0009764_decreased_sensitivity_to | 0.70418805 |
| 81 | MP0002163_abnormal_gland_morphology | 0.66311776 |
| 82 | MP0009763_increased_sensitivity_to | 0.65405540 |
| 83 | MP0010094_abnormal_chromosome_stability | 0.65130036 |
| 84 | MP0003786_premature_aging | 0.63757580 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.61148506 |
| 86 | MP0001986_abnormal_taste_sensitivity | 0.59377851 |
| 87 | MP0005174_abnormal_tail_pigmentation | 0.58240746 |
| 88 | MP0000477_abnormal_intestine_morphology | 0.57508458 |
| 89 | MP0003795_abnormal_bone_structure | 0.57208616 |
| 90 | MP0004883_abnormal_blood_vessel | 0.54549107 |
| 91 | MP0002136_abnormal_kidney_physiology | 0.54421090 |
| 92 | MP0000609_abnormal_liver_physiology | 0.54135350 |
| 93 | MP0004264_abnormal_extraembryonic_tissu | 0.53911220 |
| 94 | MP0002877_abnormal_melanocyte_morpholog | 0.53759172 |
| 95 | MP0003693_abnormal_embryo_hatching | 0.52968196 |
| 96 | MP0005076_abnormal_cell_differentiation | 0.49616651 |
| 97 | MP0008770_decreased_survivor_rate | 0.48802178 |
| 98 | MP0009278_abnormal_bone_marrow | 0.48190558 |
| 99 | MP0005379_endocrine/exocrine_gland_phen | 0.48057109 |
| 100 | MP0001216_abnormal_epidermal_layer | 0.47166066 |
| 101 | MP0008873_increased_physiological_sensi | 0.46569811 |
| 102 | MP0008569_lethality_at_weaning | 0.46028948 |
| 103 | MP0000350_abnormal_cell_proliferation | 0.43874734 |
| 104 | MP0002083_premature_death | 0.43867591 |
| 105 | MP0000920_abnormal_myelination | 0.43065512 |
| 106 | MP0001663_abnormal_digestive_system | 0.42654192 |
| 107 | MP0002095_abnormal_skin_pigmentation | 0.41894367 |
| 108 | MP0001730_embryonic_growth_arrest | 0.41507702 |
| 109 | MP0004130_abnormal_muscle_cell | 0.41428027 |
| 110 | MP0001191_abnormal_skin_condition | 0.41042019 |
| 111 | MP0005666_abnormal_adipose_tissue | 0.40912374 |
| 112 | MP0003191_abnormal_cellular_cholesterol | 0.40301778 |
| 113 | MP0009115_abnormal_fat_cell | 0.40117871 |
| 114 | MP0005381_digestive/alimentary_phenotyp | 0.39893486 |
| 115 | MP0003252_abnormal_bile_duct | 0.39857523 |
| 116 | MP0000313_abnormal_cell_death | 0.39459556 |
| 117 | MP0000249_abnormal_blood_vessel | 0.39071193 |
| 118 | MP0003943_abnormal_hepatobiliary_system | 0.37322850 |
| 119 | MP0000367_abnormal_coat/_hair | 0.37287722 |
| 120 | MP0006054_spinal_hemorrhage | 0.37219006 |
| 121 | MP0001765_abnormal_ion_homeostasis | 0.36544560 |
| 122 | MP0002693_abnormal_pancreas_physiology | 0.36322108 |
| 123 | MP0002822_catalepsy | 0.35320109 |
| 124 | MP0005166_decreased_susceptibility_to | 0.35212901 |
| 125 | MP0002970_abnormal_white_adipose | 0.33868318 |
| 126 | MP0000604_amyloidosis | 0.33578098 |
| 127 | MP0003453_abnormal_keratinocyte_physiol | 0.31131735 |
| 128 | MP0003111_abnormal_nucleus_morphology | 0.31082759 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.64972595 |
| 2 | Abnormality of T cell number (HP:0011839) | 9.19584101 |
| 3 | Combined immunodeficiency (HP:0005387) | 6.34418249 |
| 4 | Severe combined immunodeficiency (HP:0004430) | 6.24677487 |
| 5 | Abnormality of T cells (HP:0002843) | 5.93686901 |
| 6 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.82667057 |
| 7 | Nasal polyposis (HP:0100582) | 5.18509583 |
| 8 | Recurrent viral infections (HP:0004429) | 4.97912331 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 4.93706075 |
| 10 | Chronic otitis media (HP:0000389) | 4.92224459 |
| 11 | Eosinophilia (HP:0001880) | 4.68435474 |
| 12 | Stomatitis (HP:0010280) | 4.68308649 |
| 13 | Recurrent bronchitis (HP:0002837) | 4.65884720 |
| 14 | IgG deficiency (HP:0004315) | 4.59730139 |
| 15 | Recurrent fungal infections (HP:0002841) | 4.43197935 |
| 16 | Abnormality of eosinophils (HP:0001879) | 4.42890110 |
| 17 | Abnormality of the nasal mucosa (HP:0000433) | 4.24855721 |
| 18 | Granulocytopenia (HP:0001913) | 3.95925884 |
| 19 | B lymphocytopenia (HP:0010976) | 3.91389883 |
| 20 | Abnormality of B cell number (HP:0010975) | 3.91389883 |
| 21 | Autoimmune hemolytic anemia (HP:0001890) | 3.83721946 |
| 22 | Leukocytosis (HP:0001974) | 3.80788298 |
| 23 | IgM deficiency (HP:0002850) | 3.79950940 |
| 24 | Joint swelling (HP:0001386) | 3.77156660 |
| 25 | Recurrent bacterial skin infections (HP:0005406) | 3.70132573 |
| 26 | Thyroiditis (HP:0100646) | 3.68630766 |
| 27 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.68117929 |
| 28 | Increased IgM level (HP:0003496) | 3.62565675 |
| 29 | Lymphopenia (HP:0001888) | 3.60488886 |
| 30 | Myositis (HP:0100614) | 3.58754391 |
| 31 | Pustule (HP:0200039) | 3.53963458 |
| 32 | Autoimmune thrombocytopenia (HP:0001973) | 3.51509063 |
| 33 | Eczematoid dermatitis (HP:0000976) | 3.49389967 |
| 34 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.47104317 |
| 35 | Abnormality of the fingertips (HP:0001211) | 3.36308785 |
| 36 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.32439002 |
| 37 | Recurrent cutaneous fungal infections (HP:0011370) | 3.32439002 |
| 38 | Abnormality of macrophages (HP:0004311) | 3.21304857 |
| 39 | Hypoplasia of the thymus (HP:0000778) | 3.20821376 |
| 40 | Fatigue (HP:0012378) | 3.16644035 |
| 41 | Acute hepatic failure (HP:0006554) | 3.05542920 |
| 42 | Encephalitis (HP:0002383) | 3.04303003 |
| 43 | Chronic diarrhea (HP:0002028) | 2.92991107 |
| 44 | Abnormality of T cell physiology (HP:0011840) | 2.87564097 |
| 45 | Meningitis (HP:0001287) | 2.86562878 |
| 46 | Gastrointestinal infarctions (HP:0005244) | 2.82474182 |
| 47 | Hypochromic anemia (HP:0001931) | 2.81156796 |
| 48 | Basal cell carcinoma (HP:0002671) | 2.80498385 |
| 49 | Spontaneous hematomas (HP:0007420) | 2.78485997 |
| 50 | Bronchitis (HP:0012387) | 2.66922789 |
| 51 | Hypergammaglobulinemia (HP:0010702) | 2.64815331 |
| 52 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.63497668 |
| 53 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.62318587 |
| 54 | Recurrent otitis media (HP:0000403) | 2.61427540 |
| 55 | Lymphoma (HP:0002665) | 2.60264234 |
| 56 | Chronic sinusitis (HP:0011109) | 2.58778163 |
| 57 | Abnormality of oral frenula (HP:0000190) | 2.56332092 |
| 58 | Hypochromic microcytic anemia (HP:0004840) | 2.54431339 |
| 59 | Verrucae (HP:0200043) | 2.52845445 |
| 60 | Papilloma (HP:0012740) | 2.52845445 |
| 61 | Anorexia (HP:0002039) | 2.49739258 |
| 62 | Papilledema (HP:0001085) | 2.49447312 |
| 63 | Hemoptysis (HP:0002105) | 2.49401306 |
| 64 | Increased IgE level (HP:0003212) | 2.47734991 |
| 65 | Thrombocytosis (HP:0001894) | 2.43656361 |
| 66 | Urticaria (HP:0001025) | 2.43400124 |
| 67 | Retrobulbar optic neuritis (HP:0100654) | 2.42980404 |
| 68 | Optic neuritis (HP:0100653) | 2.42980404 |
| 69 | Gangrene (HP:0100758) | 2.40018196 |
| 70 | Recurrent sinusitis (HP:0011108) | 2.36974939 |
| 71 | Abnormal platelet volume (HP:0011876) | 2.34839058 |
| 72 | Obstructive lung disease (HP:0006536) | 2.34131964 |
| 73 | Chronic obstructive pulmonary disease (HP:0006510) | 2.34131964 |
| 74 | Gastrointestinal stroma tumor (HP:0100723) | 2.32316514 |
| 75 | Microcytic anemia (HP:0001935) | 2.30836467 |
| 76 | Vasculitis (HP:0002633) | 2.28987990 |
| 77 | Keratoconjunctivitis sicca (HP:0001097) | 2.24900552 |
| 78 | Recurrent abscess formation (HP:0002722) | 2.23179900 |
| 79 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.22576536 |
| 80 | Pulmonary infiltrates (HP:0002113) | 2.19446855 |
| 81 | Inflammation of the large intestine (HP:0002037) | 2.18401539 |
| 82 | Abnormality of the prostate (HP:0008775) | 2.15924357 |
| 83 | Gingivitis (HP:0000230) | 2.15866789 |
| 84 | Gastrointestinal inflammation (HP:0004386) | 2.15405081 |
| 85 | Orchitis (HP:0100796) | 2.12406326 |
| 86 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.11852369 |
| 87 | Pulmonary embolism (HP:0002204) | 2.09889064 |
| 88 | Epistaxis (HP:0000421) | 2.09710937 |
| 89 | Mediastinal lymphadenopathy (HP:0100721) | 2.09213091 |
| 90 | Aplastic anemia (HP:0001915) | 2.08923954 |
| 91 | Recurrent skin infections (HP:0001581) | 2.05800333 |
| 92 | Slow saccadic eye movements (HP:0000514) | 2.03619016 |
| 93 | Chest pain (HP:0100749) | 2.03576078 |
| 94 | Abnormal number of erythroid precursors (HP:0012131) | 2.03352674 |
| 95 | Bicuspid aortic valve (HP:0001647) | 2.02198274 |
| 96 | Ureteral stenosis (HP:0000071) | 2.01592667 |
| 97 | Bronchiectasis (HP:0002110) | 2.00417717 |
| 98 | Keratoconjunctivitis (HP:0001096) | 2.00352615 |
| 99 | Periodontitis (HP:0000704) | 2.00139747 |
| 100 | Cellular immunodeficiency (HP:0005374) | 1.97670836 |
| 101 | Arterial thrombosis (HP:0004420) | 1.97368588 |
| 102 | Amaurosis fugax (HP:0100576) | 1.97186147 |
| 103 | Hypoproteinemia (HP:0003075) | 1.95540048 |
| 104 | Cellulitis (HP:0100658) | 1.93748583 |
| 105 | Glomerulopathy (HP:0100820) | 1.92800535 |
| 106 | Trigonocephaly (HP:0000243) | 1.91869530 |
| 107 | Abnormality of the pleura (HP:0002103) | 1.90048302 |
| 108 | Prolonged bleeding time (HP:0003010) | 1.90038280 |
| 109 | Sepsis (HP:0100806) | 1.89065971 |
| 110 | IgA deficiency (HP:0002720) | 1.89050202 |
| 111 | Increased mean platelet volume (HP:0011877) | 1.88246209 |
| 112 | Prominent nose (HP:0000448) | 1.85720064 |
| 113 | Multiple enchondromatosis (HP:0005701) | 1.84709650 |
| 114 | Agammaglobulinemia (HP:0004432) | 1.84391278 |
| 115 | Dislocated radial head (HP:0003083) | 1.82632558 |
| 116 | Polyneuropathy (HP:0001271) | 1.80202554 |
| 117 | Ureteral obstruction (HP:0006000) | 1.79655456 |
| 118 | Pancytopenia (HP:0001876) | 1.78264637 |
| 119 | Purpura (HP:0000979) | 1.74284624 |
| 120 | Hepatitis (HP:0012115) | 1.74012689 |
| 121 | Abnormality of the thymus (HP:0000777) | 1.73110360 |
| 122 | Colitis (HP:0002583) | 1.72533096 |
| 123 | Seborrheic dermatitis (HP:0001051) | 1.70849564 |
| 124 | Abnormality of the radial head (HP:0003995) | 1.69350265 |
| 125 | Gingival bleeding (HP:0000225) | 1.69283100 |
| 126 | Petechiae (HP:0000967) | 1.66819397 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.75050619 |
| 2 | MAP4K1 | 5.88954554 |
| 3 | ITK | 3.73307975 |
| 4 | ZAP70 | 3.48562055 |
| 5 | STK10 | 3.18236216 |
| 6 | RIPK4 | 2.91179218 |
| 7 | GRK6 | 2.74737347 |
| 8 | JAK3 | 2.73909310 |
| 9 | MST4 | 2.48857438 |
| 10 | FGFR4 | 2.36130222 |
| 11 | NLK | 2.30827825 |
| 12 | TYK2 | 2.13478341 |
| 13 | LCK | 2.04197665 |
| 14 | IKBKE | 1.92669476 |
| 15 | CSK | 1.90483657 |
| 16 | LRRK2 | 1.75400052 |
| 17 | EEF2K | 1.73598361 |
| 18 | TEC | 1.71023375 |
| 19 | NME2 | 1.59519003 |
| 20 | MAP3K10 | 1.59136721 |
| 21 | TAOK3 | 1.58645801 |
| 22 | PRKCH | 1.57938311 |
| 23 | SYK | 1.57173072 |
| 24 | FGFR3 | 1.55404936 |
| 25 | JAK1 | 1.52867181 |
| 26 | PKN2 | 1.49736016 |
| 27 | TESK2 | 1.45892022 |
| 28 | FGR | 1.40178874 |
| 29 | FES | 1.33123141 |
| 30 | PRKCQ | 1.32720848 |
| 31 | CAMKK2 | 1.31544848 |
| 32 | HCK | 1.31530918 |
| 33 | IRAK1 | 1.24679376 |
| 34 | CLK1 | 1.24103889 |
| 35 | TRIB3 | 1.23661272 |
| 36 | MAP3K14 | 1.22744886 |
| 37 | BTK | 1.21553797 |
| 38 | MARK3 | 1.21540277 |
| 39 | PIK3CG | 1.11141181 |
| 40 | TBK1 | 1.05923655 |
| 41 | MAP2K3 | 1.04789208 |
| 42 | CAMKK1 | 1.03026399 |
| 43 | SIK2 | 1.01766556 |
| 44 | TNK2 | 1.00744489 |
| 45 | TYRO3 | 0.98194870 |
| 46 | MAP3K1 | 0.95560402 |
| 47 | MAP3K11 | 0.92793586 |
| 48 | RPS6KA4 | 0.92260331 |
| 49 | SMG1 | 0.91800717 |
| 50 | MAP3K13 | 0.90733761 |
| 51 | PDGFRB | 0.89621612 |
| 52 | BLK | 0.87862180 |
| 53 | KDR | 0.86612311 |
| 54 | KSR2 | 0.86511662 |
| 55 | MAP3K7 | 0.84252417 |
| 56 | CCNB1 | 0.76717510 |
| 57 | PIM1 | 0.76099542 |
| 58 | JAK2 | 0.74117904 |
| 59 | SIK3 | 0.71896010 |
| 60 | ALK | 0.69038562 |
| 61 | MAP3K12 | 0.68364614 |
| 62 | PASK | 0.67725118 |
| 63 | IKBKB | 0.66915070 |
| 64 | LYN | 0.65368537 |
| 65 | MELK | 0.64807640 |
| 66 | MAP2K6 | 0.62714027 |
| 67 | RAF1 | 0.62488156 |
| 68 | EPHB1 | 0.62393372 |
| 69 | CDK12 | 0.61671968 |
| 70 | INSR | 0.61266835 |
| 71 | MAP3K3 | 0.61240677 |
| 72 | NUAK1 | 0.60621123 |
| 73 | CDK4 | 0.58674695 |
| 74 | EIF2AK3 | 0.58573796 |
| 75 | FYN | 0.57711706 |
| 76 | TAOK1 | 0.57312182 |
| 77 | MARK2 | 0.55080865 |
| 78 | ILK | 0.52306719 |
| 79 | IRAK4 | 0.52075764 |
| 80 | PDK1 | 0.50589398 |
| 81 | PRPF4B | 0.50042874 |
| 82 | HIPK2 | 0.49786966 |
| 83 | CDC7 | 0.49779061 |
| 84 | FGFR1 | 0.48526733 |
| 85 | CSF1R | 0.48089154 |
| 86 | STK4 | 0.47611041 |
| 87 | TTN | 0.46287351 |
| 88 | MAPK7 | 0.44692019 |
| 89 | KIT | 0.43938097 |
| 90 | STK16 | 0.43252193 |
| 91 | TRPM7 | 0.43147676 |
| 92 | RPS6KB2 | 0.42575917 |
| 93 | TGFBR1 | 0.42532639 |
| 94 | STK11 | 0.41789731 |
| 95 | IRAK2 | 0.39484105 |
| 96 | CHUK | 0.38555128 |
| 97 | TGFBR2 | 0.37115958 |
| 98 | MAP3K2 | 0.36982294 |
| 99 | RPS6KA6 | 0.36634075 |
| 100 | MAP3K8 | 0.35250519 |
| 101 | ROCK2 | 0.35032256 |
| 102 | MAP3K5 | 0.34857361 |
| 103 | SRPK1 | 0.34769829 |
| 104 | EPHA3 | 0.32910076 |
| 105 | ERN1 | 0.32882490 |
| 106 | NEK2 | 0.31884608 |
| 107 | DMPK | 0.31006733 |
| 108 | IGF1R | 0.30863871 |
| 109 | GRK7 | 0.29929968 |
| 110 | TRIM28 | 0.29927476 |
| 111 | MAPK4 | 0.29424858 |
| 112 | CDK9 | 0.29394021 |
| 113 | MAPK11 | 0.28603398 |
| 114 | FGFR2 | 0.28018113 |
| 115 | SCYL2 | 0.28010912 |
| 116 | RPS6KC1 | 0.27244324 |
| 117 | RPS6KL1 | 0.27244324 |
| 118 | MAPK12 | 0.26943308 |
| 119 | MAPKAPK2 | 0.25974117 |
| 120 | STK24 | 0.25953678 |
| 121 | PTK6 | 0.23877559 |
| 122 | PRKD2 | 0.22797395 |
| 123 | NTRK2 | 0.20576679 |
| 124 | MAPK3 | 0.20401637 |
| 125 | SIK1 | 0.19474003 |
| 126 | CAMK4 | 0.18835837 |
| 127 | TSSK6 | 0.18768193 |
| 128 | SGK3 | 0.18286985 |
| 129 | MAPK9 | 0.15214895 |
| 130 | CDK6 | 0.14795147 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.45614216 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.70093779 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.71535825 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.66153777 |
| 5 | Measles_Homo sapiens_hsa05162 | 2.83487040 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.82498929 |
| 7 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.58674044 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.56390215 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.27322740 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.25314411 |
| 11 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.15883629 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 2.07679940 |
| 13 | Viral myocarditis_Homo sapiens_hsa05416 | 1.90300720 |
| 14 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.77063635 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.72930082 |
| 16 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.64387137 |
| 17 | Leishmaniasis_Homo sapiens_hsa05140 | 1.61121136 |
| 18 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.51607924 |
| 19 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.50019051 |
| 20 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.49040284 |
| 21 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.39497035 |
| 22 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.37701185 |
| 23 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.36952855 |
| 24 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.33796005 |
| 25 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.27592676 |
| 26 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.21350560 |
| 27 | HTLV-I infection_Homo sapiens_hsa05166 | 1.20811718 |
| 28 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.20378473 |
| 29 | Shigellosis_Homo sapiens_hsa05131 | 1.20151490 |
| 30 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.19955822 |
| 31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.18359463 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.18048525 |
| 33 | Colorectal cancer_Homo sapiens_hsa05210 | 1.15288652 |
| 34 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.15078575 |
| 35 | Spliceosome_Homo sapiens_hsa03040 | 1.13688521 |
| 36 | Hepatitis B_Homo sapiens_hsa05161 | 1.13614746 |
| 37 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.08490788 |
| 38 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.03766386 |
| 39 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.02603221 |
| 40 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.01272255 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.91975889 |
| 42 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.88306192 |
| 43 | Influenza A_Homo sapiens_hsa05164 | 0.87357633 |
| 44 | Platelet activation_Homo sapiens_hsa04611 | 0.84654127 |
| 45 | Apoptosis_Homo sapiens_hsa04210 | 0.78897515 |
| 46 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.78409542 |
| 47 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.77759349 |
| 48 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.73970531 |
| 49 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73916910 |
| 50 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.72424761 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.70984832 |
| 52 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.70791492 |
| 53 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.70345210 |
| 54 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.68457519 |
| 55 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.68398319 |
| 56 | Hepatitis C_Homo sapiens_hsa05160 | 0.64773461 |
| 57 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.61763733 |
| 58 | DNA replication_Homo sapiens_hsa03030 | 0.61634676 |
| 59 | Legionellosis_Homo sapiens_hsa05134 | 0.59940128 |
| 60 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.59664640 |
| 61 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.56761847 |
| 62 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55964628 |
| 63 | Glioma_Homo sapiens_hsa05214 | 0.55240412 |
| 64 | Thyroid cancer_Homo sapiens_hsa05216 | 0.54819941 |
| 65 | Proteasome_Homo sapiens_hsa03050 | 0.54521848 |
| 66 | Salmonella infection_Homo sapiens_hsa05132 | 0.54350658 |
| 67 | Tuberculosis_Homo sapiens_hsa05152 | 0.53961146 |
| 68 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.53556982 |
| 69 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.52463380 |
| 70 | Malaria_Homo sapiens_hsa05144 | 0.52456646 |
| 71 | Endometrial cancer_Homo sapiens_hsa05213 | 0.51057261 |
| 72 | Endocytosis_Homo sapiens_hsa04144 | 0.50957208 |
| 73 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.50190571 |
| 74 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.49789637 |
| 75 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49062255 |
| 76 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.48889764 |
| 77 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.48175874 |
| 78 | Pertussis_Homo sapiens_hsa05133 | 0.47882099 |
| 79 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.46455625 |
| 80 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.45858019 |
| 81 | Mismatch repair_Homo sapiens_hsa03430 | 0.45600929 |
| 82 | RNA degradation_Homo sapiens_hsa03018 | 0.44624435 |
| 83 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.43715281 |
| 84 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.41625394 |
| 85 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.41619414 |
| 86 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41363963 |
| 87 | Phagosome_Homo sapiens_hsa04145 | 0.40903505 |
| 88 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.40335934 |
| 89 | Asthma_Homo sapiens_hsa05310 | 0.39375411 |
| 90 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.39019460 |
| 91 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.38784435 |
| 92 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.38680871 |
| 93 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.37484133 |
| 94 | Prostate cancer_Homo sapiens_hsa05215 | 0.36985962 |
| 95 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.36672631 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.35123204 |
| 97 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.34518962 |
| 98 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.34294903 |
| 99 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.33190053 |
| 100 | Adherens junction_Homo sapiens_hsa04520 | 0.32217218 |
| 101 | RNA transport_Homo sapiens_hsa03013 | 0.31821496 |
| 102 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.31793313 |
| 103 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.30485102 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.28426796 |
| 105 | Base excision repair_Homo sapiens_hsa03410 | 0.28156748 |
| 106 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28107278 |
| 107 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.27095526 |
| 108 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.26194737 |
| 109 | Long-term potentiation_Homo sapiens_hsa04720 | 0.25774683 |
| 110 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.24167202 |
| 111 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.21435655 |
| 112 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.20720075 |
| 113 | Insulin resistance_Homo sapiens_hsa04931 | 0.18993285 |
| 114 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.18880622 |
| 115 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.18677952 |
| 116 | Pathways in cancer_Homo sapiens_hsa05200 | 0.16737162 |
| 117 | Cell cycle_Homo sapiens_hsa04110 | 0.16718032 |
| 118 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.14186830 |
| 119 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.14072401 |

