TRDV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)8.58454655
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.58454655
3positive regulation of gamma-delta T cell activation (GO:0046645)7.81268247
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.69547276
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.94046880
6regulation of B cell receptor signaling pathway (GO:0050855)6.68973919
7antigen processing and presentation of endogenous antigen (GO:0019883)6.44350055
8negative T cell selection (GO:0043383)6.09513068
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.06675437
10regulation of gamma-delta T cell differentiation (GO:0045586)5.78954236
11negative thymic T cell selection (GO:0045060)5.73496444
12response to interleukin-15 (GO:0070672)5.71331371
13regulation of gamma-delta T cell activation (GO:0046643)5.64877834
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.61970891
15cellular response to interleukin-15 (GO:0071350)5.58668441
16activated T cell proliferation (GO:0050798)5.11582083
17positive T cell selection (GO:0043368)4.98181123
18leukocyte aggregation (GO:0070486)4.92128320
19negative regulation of T cell mediated immunity (GO:0002710)4.82369177
20positive thymic T cell selection (GO:0045059)4.74928473
21antigen processing and presentation via MHC class Ib (GO:0002475)4.68272195
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.67987696
23T cell migration (GO:0072678)4.62613352
24T cell selection (GO:0045058)4.38882343
25cellular extravasation (GO:0045123)4.31217170
26thymic T cell selection (GO:0045061)4.27314232
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.24910090
28regulation of natural killer cell mediated immunity (GO:0002715)4.24910090
29regulation of regulatory T cell differentiation (GO:0045589)4.24180198
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.19475086
31positive regulation by organism of defense response of other organism involved in symbiotic interact4.19475086
32modulation by symbiont of host immune response (GO:0052553)4.19475086
33positive regulation by symbiont of host defense response (GO:0052509)4.19475086
34modulation by symbiont of host defense response (GO:0052031)4.19475086
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.19475086
36regulation of T cell mediated cytotoxicity (GO:0001914)4.15036844
37neutrophil activation involved in immune response (GO:0002283)4.13808819
38regulation of B cell differentiation (GO:0045577)4.10911147
39regulation of alpha-beta T cell proliferation (GO:0046640)4.08201310
40regulation of T cell tolerance induction (GO:0002664)4.05387021
41negative regulation of leukocyte mediated immunity (GO:0002704)4.03054801
42positive regulation of T cell mediated cytotoxicity (GO:0001916)4.00029188
43detection of other organism (GO:0098543)3.95764403
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.89601450
45detection of bacterium (GO:0016045)3.88189797
46natural killer cell differentiation (GO:0001779)3.83662849
47positive regulation of granulocyte differentiation (GO:0030854)3.81789028
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.79516534
49B cell receptor signaling pathway (GO:0050853)3.74012443
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.71002203
51neutrophil activation (GO:0042119)3.69580761
52macrophage activation involved in immune response (GO:0002281)3.65823487
53regulation of tolerance induction (GO:0002643)3.65393350
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.65102057
55interferon-gamma production (GO:0032609)3.57232820
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.54189842
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.51844679
58T cell receptor signaling pathway (GO:0050852)3.50837312
59antigen receptor-mediated signaling pathway (GO:0050851)3.50613928
60type I interferon signaling pathway (GO:0060337)3.50182235
61cellular response to type I interferon (GO:0071357)3.50182235
62negative regulation of interleukin-12 production (GO:0032695)3.49107312
63response to type I interferon (GO:0034340)3.47894196
64respiratory burst (GO:0045730)3.45615212
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.43724804
66regulation of cell killing (GO:0031341)3.39855928
67positive regulation of tolerance induction (GO:0002645)3.39756408
68dendritic cell migration (GO:0036336)3.39382789
69dendritic cell chemotaxis (GO:0002407)3.38992554
70positive regulation of natural killer cell mediated immunity (GO:0002717)3.38462560
71positive regulation of B cell differentiation (GO:0045579)3.36926300
72mast cell activation (GO:0045576)3.32337048
73regulation of interferon-beta biosynthetic process (GO:0045357)3.31639282
74granulocyte activation (GO:0036230)3.29646954
75myeloid cell activation involved in immune response (GO:0002275)3.29233328
76hepatocyte apoptotic process (GO:0097284)3.28231285
77leukocyte degranulation (GO:0043299)3.28048610
78positive regulation of humoral immune response (GO:0002922)3.27682446
79positive regulation of cell killing (GO:0031343)3.23285044
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.20435896
81detection of external biotic stimulus (GO:0098581)3.18141889
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.17583579
83interferon-gamma secretion (GO:0072643)3.16122041
84microglial cell activation (GO:0001774)3.14920552
85regulation of isotype switching to IgG isotypes (GO:0048302)3.12628371
86interferon-gamma-mediated signaling pathway (GO:0060333)3.08571264
87T cell homeostasis (GO:0043029)3.05835711
88signal complex assembly (GO:0007172)3.02707260
89negative regulation of innate immune response (GO:0045824)3.02058569
90positive regulation of isotype switching (GO:0045830)2.99968675
91negative regulation of adaptive immune response (GO:0002820)2.98156687
92cellular defense response (GO:0006968)2.95360532
93regulation of T cell mediated immunity (GO:0002709)2.93868293
94T cell proliferation (GO:0042098)2.89727182
95neutrophil mediated immunity (GO:0002446)2.86065257
96megakaryocyte development (GO:0035855)2.85166584
97negative regulation of phagocytosis (GO:0050765)2.82104996
98negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79434665
99positive regulation of T cell mediated immunity (GO:0002711)2.79190860
100regulation of alpha-beta T cell activation (GO:0046634)2.78948765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.85162663
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.56624437
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.30132378
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02239386
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.88091002
6RUNX_20019798_ChIP-Seq_JUKART_Human3.88012006
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.76365490
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.60038749
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46643039
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.37403945
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15049981
12MYB_26560356_Chip-Seq_TH2_Human3.14175682
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.02820358
14SMAD_19615063_ChIP-ChIP_OVARY_Human3.01060322
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97557144
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.88191870
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77961331
18MAF_26560356_Chip-Seq_TH1_Human2.67294552
19SPI1_23547873_ChIP-Seq_NB4_Human2.63318779
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61618731
21MYB_26560356_Chip-Seq_TH1_Human2.59522309
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55955126
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40771734
24UTX_26944678_Chip-Seq_JUKART_Human2.40768949
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39465228
26GATA3_27048872_Chip-Seq_THYMUS_Human2.32088741
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28682155
28SPI1_23127762_ChIP-Seq_K562_Human2.24264493
29SCL_19346495_ChIP-Seq_HPC-7_Human2.10336889
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07860646
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.04893061
32MAF_26560356_Chip-Seq_TH2_Human1.98655112
33MYC_22102868_ChIP-Seq_BL_Human1.96780307
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95481498
35VDR_21846776_ChIP-Seq_THP-1_Human1.82412176
36VDR_24763502_ChIP-Seq_THP-1_Human1.79239142
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78013938
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77477022
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70037530
40GATA3_26560356_Chip-Seq_TH2_Human1.69377595
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68358831
42TCF7_22412390_ChIP-Seq_EML_Mouse1.65302116
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65194570
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64332757
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61327933
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60018267
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.57837752
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55956343
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49011450
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.46443494
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46107273
52KDM2B_26808549_Chip-Seq_DND41_Human1.37854581
53PU_27001747_Chip-Seq_BMDM_Mouse1.36421202
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34543143
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34439308
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32934876
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31365544
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30423584
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29186900
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.27485268
61GATA1_22025678_ChIP-Seq_K562_Human1.27330241
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.26695854
63CIITA_25753668_ChIP-Seq_RAJI_Human1.25392653
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24938515
65VDR_24787735_ChIP-Seq_THP-1_Human1.23383828
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19967188
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19645197
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15988814
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15747664
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.13535663
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12867152
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11400200
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08411453
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03478436
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01616062
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99559105
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98804845
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95372075
79GATA1_19941826_ChIP-Seq_K562_Human0.95095438
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92558412
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90248317
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88249818
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87237536
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86088913
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84534205
86GATA3_26560356_Chip-Seq_TH1_Human0.84211809
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83545612
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83065758
89GATA2_19941826_ChIP-Seq_K562_Human0.82718294
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.80528634
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80320759
92SMRT_27268052_Chip-Seq_Bcells_Human0.79382991
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77624108
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75960533
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75139434
96NCOR1_26117541_ChIP-Seq_K562_Human0.74960733
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.74828695
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74442382
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73203911
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72845679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.47551237
2MP0005671_abnormal_response_to4.39867096
3MP0001835_abnormal_antigen_presentation4.04220912
4MP0003436_decreased_susceptibility_to3.87863298
5MP0003724_increased_susceptibility_to3.71657137
6MP0001800_abnormal_humoral_immune3.40494910
7MP0005000_abnormal_immune_tolerance3.05189618
8MP0009785_altered_susceptibility_to2.95818726
9MP0005025_abnormal_response_to2.92448877
10MP0002723_abnormal_immune_serum2.87808162
11MP0002420_abnormal_adaptive_immunity2.87108525
12MP0001819_abnormal_immune_cell2.82700605
13MP0006082_CNS_inflammation2.82643936
14MP0002419_abnormal_innate_immunity2.80274375
15MP0001790_abnormal_immune_system2.77245991
16MP0005387_immune_system_phenotype2.77245991
17MP0000685_abnormal_immune_system2.76106926
18MP0002452_abnormal_antigen_presenting2.64813567
19MP0003303_peritoneal_inflammation2.61727319
20MP0002398_abnormal_bone_marrow2.46689173
21MP0002405_respiratory_system_inflammati2.43127572
22MP0000703_abnormal_thymus_morphology2.36149251
23MP0000716_abnormal_immune_system2.26495994
24MP0005464_abnormal_platelet_physiology2.25544156
25MP0003300_gastrointestinal_ulcer2.18453445
26MP0003866_abnormal_defecation2.18269570
27MP0002148_abnormal_hypersensitivity_rea2.17395683
28MP0009333_abnormal_splenocyte_physiolog2.16814549
29MP0000689_abnormal_spleen_morphology2.11416171
30MP0002722_abnormal_immune_system2.04842430
31MP0010155_abnormal_intestine_physiology1.98149075
32MP0002396_abnormal_hematopoietic_system1.93128267
33MP0002166_altered_tumor_susceptibility1.86068346
34MP0002429_abnormal_blood_cell1.79462980
35MP0001845_abnormal_inflammatory_respons1.77565198
36MP0004381_abnormal_hair_follicle1.73811026
37MP0001533_abnormal_skeleton_physiology1.68501737
38MP0008260_abnormal_autophagy1.62485340
39MP0004947_skin_inflammation1.59136116
40MP0003172_abnormal_lysosome_physiology1.48914385
41MP0004883_abnormal_blood_vessel1.45751298
42MP0002132_abnormal_respiratory_system1.41659839
43MP0002009_preneoplasia1.39214331
44MP0008469_abnormal_protein_level1.36077645
45MP0001851_eye_inflammation1.35665127
46MP0002277_abnormal_respiratory_mucosa1.32229587
47MP0005075_abnormal_melanosome_morpholog1.28808670
48MP0003191_abnormal_cellular_cholesterol1.27210276
49MP0000858_altered_metastatic_potential1.26967136
50MP0002998_abnormal_bone_remodeling1.22784604
51MP0003828_pulmonary_edema1.21267742
52MP0003183_abnormal_peptide_metabolism1.20799940
53MP0005310_abnormal_salivary_gland1.19850908
54MP0003690_abnormal_glial_cell1.18452564
55MP0002006_tumorigenesis1.16856958
56MP0000465_gastrointestinal_hemorrhage1.14567277
57MP0009764_decreased_sensitivity_to1.11955817
58MP0001873_stomach_inflammation1.00254102
59MP0009763_increased_sensitivity_to0.96780528
60MP0004808_abnormal_hematopoietic_stem0.96054236
61MP0003448_altered_tumor_morphology0.95217846
62MP0003045_fibrosis0.92569372
63MP0005164_abnormal_response_to0.90911938
64MP0000015_abnormal_ear_pigmentation0.87922269
65MP0005451_abnormal_body_composition0.87880895
66MP0000569_abnormal_digit_pigmentation0.85272359
67MP0004130_abnormal_muscle_cell0.85203292
68MP0000490_abnormal_crypts_of0.82642054
69MP0003091_abnormal_cell_migration0.79972057
70MP0005166_decreased_susceptibility_to0.78926151
71MP0002019_abnormal_tumor_incidence0.78707030
72MP0009278_abnormal_bone_marrow0.77236626
73MP0003787_abnormal_imprinting0.75496228
74MP0001986_abnormal_taste_sensitivity0.72843382
75MP0003221_abnormal_cardiomyocyte_apopto0.71293656
76MP0005397_hematopoietic_system_phenotyp0.70066433
77MP0001545_abnormal_hematopoietic_system0.70066433
78MP0002933_joint_inflammation0.69957802
79MP0008057_abnormal_DNA_replication0.69522168
80MP0001853_heart_inflammation0.68170418
81MP0009765_abnormal_xenobiotic_induced0.67365924
82MP0003075_altered_response_to0.63468545
83MP0001663_abnormal_digestive_system0.62607632
84MP0000249_abnormal_blood_vessel0.60817515
85MP0004510_myositis0.58862811
86MP0008874_decreased_physiological_sensi0.58437549
87MP0003656_abnormal_erythrocyte_physiolo0.57793393
88MP0003795_abnormal_bone_structure0.57562054
89MP0008873_increased_physiological_sensi0.54520419
90MP0000920_abnormal_myelination0.53822042
91MP0002693_abnormal_pancreas_physiology0.53577795
92MP0002332_abnormal_exercise_endurance0.53565343
93MP0005390_skeleton_phenotype0.52328427
94MP0002928_abnormal_bile_duct0.51574439
95MP0000604_amyloidosis0.46704757
96MP0005376_homeostasis/metabolism_phenot0.46377614
97MP0001765_abnormal_ion_homeostasis0.46329685
98MP0005083_abnormal_biliary_tract0.46266993
99MP0008004_abnormal_stomach_pH0.43867380
100MP0003252_abnormal_bile_duct0.43734227

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.84970343
2Abnormality of T cell number (HP:0011839)6.25672155
3Eczematoid dermatitis (HP:0000976)5.70803105
4Myositis (HP:0100614)5.09160913
5Recurrent bacterial skin infections (HP:0005406)4.92537368
6Gastrointestinal infarctions (HP:0005244)4.91539394
7Autoimmune hemolytic anemia (HP:0001890)4.83493015
8Recurrent abscess formation (HP:0002722)4.82273600
9Orchitis (HP:0100796)4.68582938
10Stomatitis (HP:0010280)4.66200533
11Optic neuritis (HP:0100653)4.64264528
12Retrobulbar optic neuritis (HP:0100654)4.64264528
13Abnormality of macrophages (HP:0004311)4.55692210
14Elevated erythrocyte sedimentation rate (HP:0003565)4.53716269
15Abnormality of T cells (HP:0002843)4.48113329
16Encephalitis (HP:0002383)4.43036802
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.39142996
18Recurrent fungal infections (HP:0002841)4.36263850
19Recurrent cutaneous fungal infections (HP:0011370)4.18236534
20Chronic mucocutaneous candidiasis (HP:0002728)4.18236534
21Spontaneous hematomas (HP:0007420)4.15916839
22Meningitis (HP:0001287)4.15422251
23Obstructive lung disease (HP:0006536)3.90949884
24Chronic obstructive pulmonary disease (HP:0006510)3.90949884
25Severe combined immunodeficiency (HP:0004430)3.80542432
26Mediastinal lymphadenopathy (HP:0100721)3.79725491
27Recurrent skin infections (HP:0001581)3.71617576
28Keratoconjunctivitis sicca (HP:0001097)3.62430846
29Chest pain (HP:0100749)3.54848899
30Leukocytosis (HP:0001974)3.53505804
31Vasculitis (HP:0002633)3.53054613
32Recurrent gram-negative bacterial infections (HP:0005420)3.47983264
33Panhypogammaglobulinemia (HP:0003139)3.44769158
34Keratoconjunctivitis (HP:0001096)3.34192952
35Recurrent viral infections (HP:0004429)3.34079492
36Papilledema (HP:0001085)3.33255614
37Abnormality of eosinophils (HP:0001879)3.29327349
38Pulmonary infiltrates (HP:0002113)3.28666430
39Granulocytopenia (HP:0001913)3.15316808
40Prolonged bleeding time (HP:0003010)3.13527917
41Hemoptysis (HP:0002105)3.11657739
42Recurrent bronchitis (HP:0002837)3.08952211
43Pustule (HP:0200039)3.02124115
44Inflammation of the large intestine (HP:0002037)3.01634981
45Eosinophilia (HP:0001880)3.01486143
46Arterial thrombosis (HP:0004420)3.00893354
47Combined immunodeficiency (HP:0005387)2.99057714
48Pulmonary embolism (HP:0002204)2.96896411
49Increased IgM level (HP:0003496)2.93127809
50Gastrointestinal inflammation (HP:0004386)2.91475143
51IgG deficiency (HP:0004315)2.90329065
52Gingival bleeding (HP:0000225)2.89800154
53Increased IgE level (HP:0003212)2.89550714
54Epistaxis (HP:0000421)2.86548323
55Gingivitis (HP:0000230)2.86255576
56Hypoplasia of the thymus (HP:0000778)2.84116653
57Chronic diarrhea (HP:0002028)2.79718585
58Anorexia (HP:0002039)2.75172454
59Agammaglobulinemia (HP:0004432)2.73873781
60Abnormality of T cell physiology (HP:0011840)2.73706613
61Joint swelling (HP:0001386)2.71751079
62Urticaria (HP:0001025)2.67211577
63Lymphopenia (HP:0001888)2.62180476
64Hypoproteinemia (HP:0003075)2.58124828
65Thyroiditis (HP:0100646)2.57963731
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.48563983
67Gangrene (HP:0100758)2.44838704
68Hypochromic anemia (HP:0001931)2.43031366
69Hemiplegia (HP:0002301)2.34467259
70Cellulitis (HP:0100658)2.33952723
71Hypochromic microcytic anemia (HP:0004840)2.33046080
72Sepsis (HP:0100806)2.32520566
73Abnormality of the pleura (HP:0002103)2.29672440
74Glomerulopathy (HP:0100820)2.28766206
75IgM deficiency (HP:0002850)2.28316973
76Amaurosis fugax (HP:0100576)2.27085267
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26927041
78Microcytic anemia (HP:0001935)2.23350512
79Colitis (HP:0002583)2.17678989
80Petechiae (HP:0000967)2.14092983
81Aplasia/Hypoplasia of the thymus (HP:0010515)2.12441206
82Hypergammaglobulinemia (HP:0010702)2.11692007
83Slow saccadic eye movements (HP:0000514)2.11137254
84Abnormal platelet volume (HP:0011876)2.10642703
85Verrucae (HP:0200043)2.10556439
86Papilloma (HP:0012740)2.10556439
87Subacute progressive viral hepatitis (HP:0006572)2.06306001
88Lymphoma (HP:0002665)2.05569974
89Abnormality of binocular vision (HP:0011514)2.04282650
90Diplopia (HP:0000651)2.04282650
91Keratitis (HP:0000491)2.02322625
92Viral hepatitis (HP:0006562)2.02285978
93Osteomyelitis (HP:0002754)1.98376135
94Acute hepatic failure (HP:0006554)1.98182412
95Episodic fever (HP:0001954)1.97699074
96Chronic otitis media (HP:0000389)1.97206941
97Stomach cancer (HP:0012126)1.95130733
98Abnormality of the prostate (HP:0008775)1.91629563
99Vertigo (HP:0002321)1.90023618
100Polyneuropathy (HP:0001271)1.88373405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.23701120
2RIPK43.67748675
3FES3.22274670
4TXK3.19694921
5CSK2.93688320
6TYK22.93116129
7SIK32.46614125
8PRPF4B2.41827093
9BLK2.29170574
10JAK32.16798810
11TAOK32.12273815
12ZAP702.09511350
13JAK12.07912656
14BTK2.05140299
15IRAK42.03587532
16MAP2K32.00926687
17GRK61.94619608
18ITK1.84778111
19STK101.79665790
20TNK21.77432643
21SYK1.73162525
22IKBKE1.71672988
23HCK1.68625104
24PIK3CG1.62754655
25MAP3K131.58741279
26EPHB11.58023459
27TEC1.52324480
28ERN11.49469186
29FGFR41.49423053
30LCK1.46353082
31FGR1.44197719
32MAP3K141.42876732
33MARK31.42407956
34CAMKK21.40520234
35GRK71.40272043
36TGFBR21.35184993
37LYN1.30827562
38FGFR31.25937547
39JAK21.21463058
40MAP3K31.17847214
41SIK21.17742284
42CSF1R1.15030352
43MAP3K101.06691541
44STK381.04497079
45YES11.02151734
46KIT0.99613054
47KSR20.99315694
48NLK0.97329860
49TBK10.96035888
50TAOK10.94443530
51PRKCQ0.93710391
52MAP3K10.90980206
53PDK10.89152904
54LRRK20.85257405
55CAMKK10.84919330
56MARK20.84032537
57FYN0.79551325
58TYRO30.78603061
59PASK0.76072953
60MOS0.74161659
61IKBKB0.68584955
62BMPR20.67105866
63RAF10.66782832
64MAP3K110.66571685
65SGK30.66074898
66MAP3K20.65969888
67MAPK110.63114438
68CDK30.61923449
69MAP2K60.61296452
70STK40.60303237
71CDK40.60289076
72PTK60.59247487
73HIPK20.57938069
74PIM10.57365221
75MAP3K70.50410076
76MAPK120.49887408
77EPHA30.49194050
78KSR10.48230046
79CLK10.47489502
80DYRK1B0.46595241
81IRAK10.46249843
82SGK20.46215925
83SIK10.46209803
84STK110.45728951
85NEK60.39381038
86PTK2B0.39119164
87GRK50.38922380
88TESK20.38474271
89PDPK10.37907163
90PDGFRB0.37298616
91RET0.37249657
92CDK60.36504488
93PRKD20.33841098
94MAPKAPK20.33637364
95MAP3K50.32345774
96MAPK70.31849697
97CDK190.31830927
98TRIB30.30546712
99MELK0.30248199
100RPS6KA40.29419892

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.98092843
2Primary immunodeficiency_Homo sapiens_hsa053403.63279258
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.50523635
4T cell receptor signaling pathway_Homo sapiens_hsa046602.79390596
5Antigen processing and presentation_Homo sapiens_hsa046122.79008225
6Allograft rejection_Homo sapiens_hsa053302.52616574
7Autoimmune thyroid disease_Homo sapiens_hsa053202.41114792
8Osteoclast differentiation_Homo sapiens_hsa043802.39152571
9Measles_Homo sapiens_hsa051622.31233396
10Leishmaniasis_Homo sapiens_hsa051402.17286865
11B cell receptor signaling pathway_Homo sapiens_hsa046622.10507756
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95114290
13Hematopoietic cell lineage_Homo sapiens_hsa046401.91945744
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85511072
15Staphylococcus aureus infection_Homo sapiens_hsa051501.84086475
16Type I diabetes mellitus_Homo sapiens_hsa049401.83379662
17Viral myocarditis_Homo sapiens_hsa054161.76707967
18Acute myeloid leukemia_Homo sapiens_hsa052211.68317733
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67864747
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66334143
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65078500
22Chemokine signaling pathway_Homo sapiens_hsa040621.62205568
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.53878034
24Tuberculosis_Homo sapiens_hsa051521.49929666
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48326731
26Non-small cell lung cancer_Homo sapiens_hsa052231.46735586
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.46255912
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43790807
29Herpes simplex infection_Homo sapiens_hsa051681.41202966
30Malaria_Homo sapiens_hsa051441.37538064
31Platelet activation_Homo sapiens_hsa046111.32313031
32Influenza A_Homo sapiens_hsa051641.28628975
33Hepatitis B_Homo sapiens_hsa051611.27472578
34Toxoplasmosis_Homo sapiens_hsa051451.25394745
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.21637582
36Pancreatic cancer_Homo sapiens_hsa052121.18835973
37TNF signaling pathway_Homo sapiens_hsa046681.11107254
38Legionellosis_Homo sapiens_hsa051341.09216280
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06393111
40Hepatitis C_Homo sapiens_hsa051601.01598482
41VEGF signaling pathway_Homo sapiens_hsa043700.98883169
42Chronic myeloid leukemia_Homo sapiens_hsa052200.97870580
43Apoptosis_Homo sapiens_hsa042100.95731297
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.94768015
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91213481
46Renal cell carcinoma_Homo sapiens_hsa052110.90877336
47Prolactin signaling pathway_Homo sapiens_hsa049170.86818743
48Endocytosis_Homo sapiens_hsa041440.84614397
49Shigellosis_Homo sapiens_hsa051310.84016869
50FoxO signaling pathway_Homo sapiens_hsa040680.83900491
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82022895
52Endometrial cancer_Homo sapiens_hsa052130.81827012
53Viral carcinogenesis_Homo sapiens_hsa052030.81624942
54Phagosome_Homo sapiens_hsa041450.81424530
55Colorectal cancer_Homo sapiens_hsa052100.80534896
56HTLV-I infection_Homo sapiens_hsa051660.77270032
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.76906639
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76015825
59Inositol phosphate metabolism_Homo sapiens_hsa005620.75873277
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.75024155
61Epstein-Barr virus infection_Homo sapiens_hsa051690.72404110
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.70421174
63Pertussis_Homo sapiens_hsa051330.70350132
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69608529
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68659885
66Asthma_Homo sapiens_hsa053100.68113969
67Regulation of autophagy_Homo sapiens_hsa041400.67558875
68African trypanosomiasis_Homo sapiens_hsa051430.67338657
69mTOR signaling pathway_Homo sapiens_hsa041500.66281982
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66024572
71Choline metabolism in cancer_Homo sapiens_hsa052310.65823607
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63300207
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59969011
74Notch signaling pathway_Homo sapiens_hsa043300.59694837
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57881198
76Dorso-ventral axis formation_Homo sapiens_hsa043200.55632177
77Other glycan degradation_Homo sapiens_hsa005110.54736876
78Salmonella infection_Homo sapiens_hsa051320.54193490
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51908589
80Rheumatoid arthritis_Homo sapiens_hsa053230.51511727
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51083074
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47621947
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47391898
84Insulin resistance_Homo sapiens_hsa049310.45668163
85Prostate cancer_Homo sapiens_hsa052150.45054218
86GnRH signaling pathway_Homo sapiens_hsa049120.43725804
87Thyroid cancer_Homo sapiens_hsa052160.43081640
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43055755
89Long-term potentiation_Homo sapiens_hsa047200.41456450
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41446160
91ErbB signaling pathway_Homo sapiens_hsa040120.41216529
92MAPK signaling pathway_Homo sapiens_hsa040100.40722165
93Rap1 signaling pathway_Homo sapiens_hsa040150.40587128
94Glioma_Homo sapiens_hsa052140.40079238
95Ras signaling pathway_Homo sapiens_hsa040140.38385614
96HIF-1 signaling pathway_Homo sapiens_hsa040660.36944678
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.35560434
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35162238
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32937123
100Lysosome_Homo sapiens_hsa041420.32144850

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