TRDV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)9.42891421
2negative regulation by host of viral transcription (GO:0043922)8.48433508
3eosinophil migration (GO:0072677)8.48057878
4regulation of chronic inflammatory response (GO:0002676)8.36877501
5regulation of activation of Janus kinase activity (GO:0010533)8.00341524
6response to pheromone (GO:0019236)7.32274573
7regulation of chemokine-mediated signaling pathway (GO:0070099)7.16906582
8negative regulation of T cell apoptotic process (GO:0070233)6.80148514
9regulation of mononuclear cell migration (GO:0071675)6.62327490
10macrophage chemotaxis (GO:0048246)6.52655629
11regulation of regulatory T cell differentiation (GO:0045589)6.51243505
12positive regulation of T cell apoptotic process (GO:0070234)6.34531809
13DNA deamination (GO:0045006)6.26195344
14regulation of T cell chemotaxis (GO:0010819)6.24670116
15positive regulation of T cell chemotaxis (GO:0010820)6.24670116
16positive regulation of natural killer cell mediated immunity (GO:0002717)6.20750604
17positive regulation of monocyte chemotaxis (GO:0090026)6.19810579
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.17552855
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.07288723
20regulation of lymphocyte chemotaxis (GO:1901623)5.92396357
21regulation of macrophage chemotaxis (GO:0010758)5.91862118
22positive regulation of dendritic spine morphogenesis (GO:0061003)5.81299368
23positive regulation of translational initiation (GO:0045948)5.57692221
24cellular response to interleukin-15 (GO:0071350)5.55193846
25positive thymic T cell selection (GO:0045059)5.49082434
26positive regulation of gamma-delta T cell activation (GO:0046645)5.23429222
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.17046716
28regulation of natural killer cell mediated immunity (GO:0002715)5.17046716
29positive regulation of lymphocyte apoptotic process (GO:0070230)5.11774383
30peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.05812256
31response to interleukin-15 (GO:0070672)5.05456063
32fat-soluble vitamin biosynthetic process (GO:0042362)4.94366785
33dendritic cell chemotaxis (GO:0002407)4.94191401
34positive T cell selection (GO:0043368)4.94058162
35protein localization to synapse (GO:0035418)4.93645411
36modulation by host of viral transcription (GO:0043921)4.88946381
37modulation by host of symbiont transcription (GO:0052472)4.88946381
38negative regulation of viral transcription (GO:0032897)4.86513120
39positive regulation of interleukin-8 secretion (GO:2000484)4.78293382
40positive regulation of calcium-mediated signaling (GO:0050850)4.75741723
41monocyte chemotaxis (GO:0002548)4.71336792
42regulation of gamma-delta T cell differentiation (GO:0045586)4.66940509
43modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.63145575
44presynaptic membrane assembly (GO:0097105)4.59150823
45positive regulation of cellular amide metabolic process (GO:0034250)4.58595391
46negative regulation of lymphocyte apoptotic process (GO:0070229)4.55881538
47regulation of T-helper 1 cell differentiation (GO:0045625)4.54904322
48positive regulation of dendritic spine development (GO:0060999)4.42205050
49neurotransmitter-gated ion channel clustering (GO:0072578)4.35629447
50positive regulation of lymphocyte migration (GO:2000403)4.35088935
51regulation of T cell apoptotic process (GO:0070232)4.33032505
52regulation of interleukin-2 biosynthetic process (GO:0045076)4.29397397
53granulocyte activation (GO:0036230)4.29143113
54fatty acid elongation (GO:0030497)4.26247487
55thymic T cell selection (GO:0045061)4.23840813
56regulation of monocyte chemotaxis (GO:0090025)4.14694684
57negative regulation of protein localization to cell surface (GO:2000009)4.13770046
58ether lipid metabolic process (GO:0046485)4.12310409
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.08484330
60regulation of homotypic cell-cell adhesion (GO:0034110)4.08158001
61presynaptic membrane organization (GO:0097090)4.07936317
62positive regulation of cell adhesion mediated by integrin (GO:0033630)4.03793938
63diterpenoid biosynthetic process (GO:0016102)3.98462177
64myelin maintenance (GO:0043217)3.97720073
65negative regulation of viral genome replication (GO:0045071)3.97353146
66regulation of gamma-delta T cell activation (GO:0046643)3.96973809
67positive regulation of leukocyte apoptotic process (GO:2000108)3.96693535
68activated T cell proliferation (GO:0050798)3.96211282
69negative regulation of B cell proliferation (GO:0030889)3.92314307
70dendritic cell migration (GO:0036336)3.90523839
71regulation of T cell tolerance induction (GO:0002664)3.85600236
72negative regulation of T cell receptor signaling pathway (GO:0050860)3.83586998
73neutrophil activation (GO:0042119)3.83269059
74positive regulation of cell killing (GO:0031343)3.79015238
75localization within membrane (GO:0051668)3.77419264
76positive regulation of smooth muscle cell migration (GO:0014911)3.76371486
77central nervous system myelination (GO:0022010)3.74933980
78axon ensheathment in central nervous system (GO:0032291)3.74933980
79response to methylmercury (GO:0051597)3.72218592
80negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.71872651
81T cell costimulation (GO:0031295)3.71344145
82negative regulation of keratinocyte proliferation (GO:0010839)3.70423458
83T cell selection (GO:0045058)3.69989690
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67435576
85lymphocyte costimulation (GO:0031294)3.67413697
86cytidine metabolic process (GO:0046087)3.66825365
87cytidine catabolic process (GO:0006216)3.66825365
88cytidine deamination (GO:0009972)3.66825365
89negative T cell selection (GO:0043383)3.64517955
90mechanosensory behavior (GO:0007638)3.63670895
91positive regulation of tolerance induction (GO:0002645)3.62024970
92regulation of interleukin-12 biosynthetic process (GO:0045075)3.60913961
93modification by host of symbiont morphology or physiology (GO:0051851)3.56415264
94L-amino acid import (GO:0043092)3.54415522
95positive regulation of T cell migration (GO:2000406)3.52657889
96amino acid import (GO:0043090)3.51083764
97Arp2/3 complex-mediated actin nucleation (GO:0034314)3.49715076
98regulation of leukocyte mediated cytotoxicity (GO:0001910)3.49001342
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48874436
100negative thymic T cell selection (GO:0045060)3.46592706
101regulation of calcium-mediated signaling (GO:0050848)3.46567244
102regulation of T cell receptor signaling pathway (GO:0050856)3.45614464
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45416114
104negative regulation of leukocyte apoptotic process (GO:2000107)3.44742347
105import into cell (GO:0098657)3.44477922
106regulation of protein kinase C signaling (GO:0090036)3.42122926
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38615096
108regulation of lymphocyte migration (GO:2000401)3.38391288
109nucleoside diphosphate catabolic process (GO:0009134)3.38299713
110negative regulation of T cell differentiation (GO:0045581)3.35409875
111Golgi to endosome transport (GO:0006895)3.33355594
112cerebral cortex radially oriented cell migration (GO:0021799)3.33150538
113regulation of cell killing (GO:0031341)3.33091120
114ear development (GO:0043583)3.27900067
115negative regulation of B cell activation (GO:0050869)3.27894415
116interaction with symbiont (GO:0051702)3.25965162
117asymmetric protein localization (GO:0008105)3.23890547
118negative regulation of T cell activation (GO:0050868)3.23179940
119positive regulation of B cell differentiation (GO:0045579)3.23023197
120regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21510496
121regulation of interleukin-8 secretion (GO:2000482)3.20690068
122positive regulation of viral genome replication (GO:0045070)3.19079772
123T cell migration (GO:0072678)3.17704227
124regulation of lymphocyte apoptotic process (GO:0070228)3.17507495
125pyrimidine nucleoside catabolic process (GO:0046135)3.16964980
126negative regulation of neurotransmitter transport (GO:0051589)3.16406113
127positive regulation of protein kinase C signaling (GO:0090037)3.12915447
128positive regulation of macrophage differentiation (GO:0045651)3.12130264
129regulation of protein glycosylation (GO:0060049)3.06985730
130auditory behavior (GO:0031223)3.06255127
131negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02266379
132photoreceptor cell maintenance (GO:0045494)2.99623159
133digestive tract morphogenesis (GO:0048546)2.96421005
134apical protein localization (GO:0045176)2.95987869
135regulation of dendritic spine morphogenesis (GO:0061001)2.94570254
136postsynaptic membrane organization (GO:0001941)2.94238592
137oligosaccharide catabolic process (GO:0009313)2.91770066
138positive regulation of protein homodimerization activity (GO:0090073)2.91452105
139vitamin biosynthetic process (GO:0009110)2.89864470
140positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.89788524
141nonmotile primary cilium assembly (GO:0035058)2.89771373
142establishment of endothelial barrier (GO:0061028)2.89466929
143regulation of beta-amyloid formation (GO:1902003)2.88863462
144regulation of bile acid biosynthetic process (GO:0070857)2.88487245
145negative regulation of neurotransmitter secretion (GO:0046929)2.87509269
146nerve growth factor signaling pathway (GO:0038180)2.85659520
147coenzyme catabolic process (GO:0009109)2.84082573
148regulation of dendritic spine development (GO:0060998)2.80276269
149negative regulation of amino acid transport (GO:0051956)2.79314713
150regulation of inositol phosphate biosynthetic process (GO:0010919)2.76596010
151intestinal cholesterol absorption (GO:0030299)2.76014312
152superoxide anion generation (GO:0042554)2.75985618
153positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.74306575
154positive regulation of synapse assembly (GO:0051965)2.70383251
155cellular potassium ion homeostasis (GO:0030007)2.69695679
156positive regulation of dendrite development (GO:1900006)2.67396104
157positive regulation of uterine smooth muscle contraction (GO:0070474)2.65902185
158endothelial cell development (GO:0001885)2.64351006
159membrane raft organization (GO:0031579)2.61622943
160production of molecular mediator involved in inflammatory response (GO:0002532)2.61046811
161cellular protein complex localization (GO:0034629)2.60915694
162pyrimidine ribonucleoside catabolic process (GO:0046133)2.60757705
163mannosylation (GO:0097502)2.60669788
164neuron cell-cell adhesion (GO:0007158)2.56922819
165biotin metabolic process (GO:0006768)2.56877274
166positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.55906693
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54958151
168positive regulation of actin cytoskeleton reorganization (GO:2000251)2.53959443
169preassembly of GPI anchor in ER membrane (GO:0016254)2.53498279
170negative regulation of glycoprotein metabolic process (GO:1903019)2.53483743
171vocalization behavior (GO:0071625)2.53248769
172response to auditory stimulus (GO:0010996)2.52823039
173negative regulation of glycoprotein biosynthetic process (GO:0010561)2.50340471
174negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49383894
175cell-cell junction maintenance (GO:0045217)2.49361316
176synaptic vesicle maturation (GO:0016188)2.49076017
177N-acetylglucosamine metabolic process (GO:0006044)2.46839365
178neurotransmitter uptake (GO:0001504)2.46722539
179gamma-aminobutyric acid signaling pathway (GO:0007214)2.45315597
180eye photoreceptor cell differentiation (GO:0001754)2.44481923
181photoreceptor cell differentiation (GO:0046530)2.44481923
182long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.44092537
183neuronal action potential propagation (GO:0019227)2.42493888
184respiratory burst (GO:0045730)2.42155907
185cofactor catabolic process (GO:0051187)2.41930761
186long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.40885930
187response to lipoprotein particle (GO:0055094)2.40014088
188nucleotide transmembrane transport (GO:1901679)2.39279766
189positive regulation of CREB transcription factor activity (GO:0032793)2.37877154
190cellular response to cholesterol (GO:0071397)2.37621085
191retina layer formation (GO:0010842)2.37267998
192cellular anion homeostasis (GO:0030002)2.36245808
193cell junction maintenance (GO:0034331)2.34566091
194inositol phosphate-mediated signaling (GO:0048016)2.33930564
195positive regulation of toll-like receptor signaling pathway (GO:0034123)2.33836390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.05160573
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.41959680
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.53296969
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.43505369
5RUNX_20019798_ChIP-Seq_JUKART_Human3.20940764
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14062099
7MYB_26560356_Chip-Seq_TH2_Human3.07943388
8GBX2_23144817_ChIP-Seq_PC3_Human2.94715753
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93496348
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76673347
11EZH2_22144423_ChIP-Seq_EOC_Human2.75591117
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61105846
13GATA3_27048872_Chip-Seq_THYMUS_Human2.54271715
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53908589
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43163385
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42357902
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39289063
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.39023509
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.31013844
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29869767
21UTX_26944678_Chip-Seq_JUKART_Human2.29849672
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28186464
23MYB_26560356_Chip-Seq_TH1_Human2.27238980
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25657254
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24176806
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.19978534
27VDR_22108803_ChIP-Seq_LS180_Human2.19523617
28MAF_26560356_Chip-Seq_TH2_Human2.17386109
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16471169
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14834683
31SMAD_19615063_ChIP-ChIP_OVARY_Human2.12341335
32AR_21572438_ChIP-Seq_LNCaP_Human2.10438868
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07302578
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06763002
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06312790
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04352221
37GATA1_22025678_ChIP-Seq_K562_Human2.03837659
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94231534
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94199225
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94199225
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.92792358
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89580594
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.89389004
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.86156331
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84261565
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84052089
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82837008
48GATA3_26560356_Chip-Seq_TH2_Human1.82263151
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81924227
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80450001
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.72470105
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72068121
53MAF_26560356_Chip-Seq_TH1_Human1.70529417
54TAF15_26573619_Chip-Seq_HEK293_Human1.67368829
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65970967
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65550802
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63459998
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60880506
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59531326
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59203242
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59094245
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58796315
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55515871
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54156911
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.52575483
66CIITA_25753668_ChIP-Seq_RAJI_Human1.52121176
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.50255548
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49297896
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.47442763
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.47393293
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45827932
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45407486
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45163926
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44621164
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.43863680
76P300_19829295_ChIP-Seq_ESCs_Human1.43544376
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42500498
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38615832
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38150594
80ER_23166858_ChIP-Seq_MCF-7_Human1.37453121
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.36319841
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.34770907
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33660262
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32101271
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.30835482
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30104025
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29585288
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.29416171
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26685784
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.25003494
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24699293
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24699293
93SMAD4_21799915_ChIP-Seq_A2780_Human1.24597332
94GATA3_26560356_Chip-Seq_TH1_Human1.24033291
95TP53_18474530_ChIP-ChIP_U2OS_Human1.23499450
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22643411
97TP53_16413492_ChIP-PET_HCT116_Human1.21160483
98IRF1_19129219_ChIP-ChIP_H3396_Human1.20797470
99TCF4_23295773_ChIP-Seq_U87_Human1.20604212
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.19846463
101REST_21632747_ChIP-Seq_MESCs_Mouse1.19831312
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.18352319
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17558948
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.16916970
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16810695
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16656749
107MYC_22102868_ChIP-Seq_BL_Human1.16593497
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16588654
109DROSHA_22980978_ChIP-Seq_HELA_Human1.16578086
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.16387816
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.16156525
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.15829052
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14861865
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14413041
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.14109124
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13976520
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.13760257
118KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13628216
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13171095
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12922773
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12801758
122P53_22387025_ChIP-Seq_ESCs_Mouse1.12553055
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12542347
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11041983
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10050545
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09991403
127AR_25329375_ChIP-Seq_VCAP_Human1.08121887
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07469229
129P300_18555785_Chip-Seq_ESCs_Mouse1.06866588
130SOX2_18555785_Chip-Seq_ESCs_Mouse1.06040132
131SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05473543
132SPI1_23547873_ChIP-Seq_NB4_Human1.04990630
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.04710905
134HTT_18923047_ChIP-ChIP_STHdh_Human1.04033924
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03894047
136SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03010993
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02721107
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02671976
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02197748
140IGF1R_20145208_ChIP-Seq_DFB_Human1.02120767
141STAT3_23295773_ChIP-Seq_U87_Human1.00959674
142NMYC_18555785_Chip-Seq_ESCs_Mouse1.00157119
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.99652815
144TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92287331
145GATA6_21074721_ChIP-Seq_CACO-2_Human0.92265743
146TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91329300
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91101249
148FOXP3_21729870_ChIP-Seq_TREG_Human0.89061890
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88137787
150BCAT_22108803_ChIP-Seq_LS180_Human0.87271501
151TP53_22573176_ChIP-Seq_HFKS_Human0.87212549
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86228748
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85390497
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85348817
155JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84951095
156TAF2_19829295_ChIP-Seq_ESCs_Human0.81341092
157FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80708476
158GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80559383
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79929009
160RBPJ_21746931_ChIP-Seq_IB4_Human0.78519749
161POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77937580
162CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.76943039
163VDR_23849224_ChIP-Seq_CD4+_Human0.76596388
164RUNX1_22412390_ChIP-Seq_EML_Mouse0.76219172
165ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75688274
166STAT1_20625510_ChIP-Seq_HELA_Human0.73648270
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.73375538
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.72785205
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72385014
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72325822
171CTCF_21964334_Chip-Seq_Bcells_Human0.71801047
172CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71174759
173SA1_27219007_Chip-Seq_Bcells_Human0.70663314
174BRD4_27068464_Chip-Seq_AML-cells_Mouse0.68978937
175SCL_19346495_ChIP-Seq_HPC-7_Human0.66208562
176YY1_22570637_ChIP-Seq_MALME-3M_Human0.65749589
177FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64256756
178HNFA_21074721_ChIP-Seq_CACO-2_Human0.64053324
179RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.62732404
180GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.62044695
181EST1_17652178_ChIP-ChIP_JURKAT_Human0.61880504
182HOXB7_26014856_ChIP-Seq_BT474_Human0.61098800
183P300_27268052_Chip-Seq_Bcells_Human0.61049892
184VDR_21846776_ChIP-Seq_THP-1_Human0.61038083
185SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.60938797
186CEBPB_22108803_ChIP-Seq_LS180_Human0.60798326
187PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.60376782
188YY1_21170310_ChIP-Seq_MESCs_Mouse0.58442112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.69301003
2MP0003136_yellow_coat_color7.19082817
3MP0005083_abnormal_biliary_tract5.11547227
4MP0003950_abnormal_plasma_membrane4.49617097
5MP0003763_abnormal_thymus_physiology4.44691418
6MP0001188_hyperpigmentation3.05459891
7MP0001873_stomach_inflammation3.03962000
8MP0005084_abnormal_gallbladder_morpholo3.01415867
9MP0009333_abnormal_splenocyte_physiolog2.98922603
10MP0001800_abnormal_humoral_immune2.94275468
11MP0002163_abnormal_gland_morphology2.83040020
12MP0004270_analgesia2.73417496
13MP0002723_abnormal_immune_serum2.63772714
14MP0003718_maternal_effect2.55342729
15MP0002420_abnormal_adaptive_immunity2.50266137
16MP0001819_abnormal_immune_cell2.42040957
17MP0001835_abnormal_antigen_presentation2.36757926
18MP0010307_abnormal_tumor_latency2.35238450
19MP0002405_respiratory_system_inflammati2.34821050
20MP0003880_abnormal_central_pattern2.33022854
21MP0004381_abnormal_hair_follicle2.32890998
22MP0002398_abnormal_bone_marrow2.32140229
23MP0000566_synostosis2.26983829
24MP0003866_abnormal_defecation2.24655400
25MP0003183_abnormal_peptide_metabolism2.18528473
26MP0005379_endocrine/exocrine_gland_phen2.14285975
27MP0002722_abnormal_immune_system2.10077895
28MP0002933_joint_inflammation2.09006584
29MP0000716_abnormal_immune_system2.08948628
30MP0004145_abnormal_muscle_electrophysio2.07540509
31MP0002452_abnormal_antigen_presenting2.07229096
32MP0000703_abnormal_thymus_morphology2.06406310
33MP0003724_increased_susceptibility_to2.06201095
34MP0005409_darkened_coat_color2.02891633
35MP0010155_abnormal_intestine_physiology2.00130192
36MP0003690_abnormal_glial_cell1.97238757
37MP0005025_abnormal_response_to1.95409774
38MP0000689_abnormal_spleen_morphology1.95123781
39MP0005387_immune_system_phenotype1.93885043
40MP0001790_abnormal_immune_system1.93885043
41MP0002877_abnormal_melanocyte_morpholog1.92638452
42MP0005464_abnormal_platelet_physiology1.92570176
43MP0004782_abnormal_surfactant_physiolog1.90935453
44MP0003045_fibrosis1.87552298
45MP0001486_abnormal_startle_reflex1.86826620
46MP0003806_abnormal_nucleotide_metabolis1.84295852
47MP0005310_abnormal_salivary_gland1.83972545
48MP0000920_abnormal_myelination1.79336081
49MP0005257_abnormal_intraocular_pressure1.74612369
50MP0003195_calcinosis1.68181253
51MP0003786_premature_aging1.66618661
52MP0002138_abnormal_hepatobiliary_system1.64538838
53MP0005171_absent_coat_pigmentation1.63670859
54MP0002429_abnormal_blood_cell1.63439475
55MP0002064_seizures1.61646743
56MP0000685_abnormal_immune_system1.60854382
57MP0001501_abnormal_sleep_pattern1.58274685
58MP0003075_altered_response_to1.56730428
59MP0001485_abnormal_pinna_reflex1.56092359
60MP0001845_abnormal_inflammatory_respons1.54823207
61MP0005165_increased_susceptibility_to1.53629437
62MP0001853_heart_inflammation1.51360924
63MP0001851_eye_inflammation1.46088515
64MP0009046_muscle_twitch1.45964134
65MP0005167_abnormal_blood-brain_barrier1.45827901
66MP0002909_abnormal_adrenal_gland1.43737048
67MP0006292_abnormal_olfactory_placode1.41914970
68MP0003172_abnormal_lysosome_physiology1.41783851
69MP0009745_abnormal_behavioral_response1.40780140
70MP0001968_abnormal_touch/_nociception1.37747616
71MP0002638_abnormal_pupillary_reflex1.34698080
72MP0002396_abnormal_hematopoietic_system1.34238108
73MP0004185_abnormal_adipocyte_glucose1.31801369
74MP0002572_abnormal_emotion/affect_behav1.31131472
75MP0004947_skin_inflammation1.30581293
76MP0004043_abnormal_pH_regulation1.29483060
77MP0003959_abnormal_lean_body1.28463277
78MP0002272_abnormal_nervous_system1.28317873
79MP0009840_abnormal_foam_cell1.27102829
80MP0008004_abnormal_stomach_pH1.26772448
81MP0003635_abnormal_synaptic_transmissio1.21880187
82MP0008569_lethality_at_weaning1.21447991
83MP0001661_extended_life_span1.21432440
84MP0005551_abnormal_eye_electrophysiolog1.20732767
85MP0001664_abnormal_digestion1.17866193
86MP0002734_abnormal_mechanical_nocicepti1.16262388
87MP0005365_abnormal_bile_salt1.16048459
88MP0003329_amyloid_beta_deposits1.13695760
89MP0008469_abnormal_protein_level1.11006934
90MP0004134_abnormal_chest_morphology1.10685986
91MP0005645_abnormal_hypothalamus_physiol1.08310527
92MP0003634_abnormal_glial_cell1.07415635
93MP0003448_altered_tumor_morphology1.06246866
94MP0002557_abnormal_social/conspecific_i1.05514106
95MP0002736_abnormal_nociception_after1.04266768
96MP0001502_abnormal_circadian_rhythm1.01192943
97MP0004147_increased_porphyrin_level1.01140064
98MP0000858_altered_metastatic_potential1.00343300
99MP0004742_abnormal_vestibular_system0.99941903
100MP0000372_irregular_coat_pigmentation0.98824955
101MP0005647_abnormal_sex_gland0.98699409
102MP0001324_abnormal_eye_pigmentation0.98482336
103MP0002063_abnormal_learning/memory/cond0.98373365
104MP0003436_decreased_susceptibility_to0.97511330
105MP0001348_abnormal_lacrimal_gland0.96364690
106MP0003633_abnormal_nervous_system0.96319591
107MP0005253_abnormal_eye_physiology0.94974074
108MP0002067_abnormal_sensory_capabilities0.94777969
109MP0005058_abnormal_lysosome_morphology0.90417746
110MP0003943_abnormal_hepatobiliary_system0.90376517
111MP0000778_abnormal_nervous_system0.88783807
112MP0003631_nervous_system_phenotype0.87603056
113MP0004484_altered_response_of0.85304359
114MP0009765_abnormal_xenobiotic_induced0.85103538
115MP0005174_abnormal_tail_pigmentation0.84910129
116MP0002009_preneoplasia0.83945239
117MP0002419_abnormal_innate_immunity0.83893965
118MP0003938_abnormal_ear_development0.83703738
119MP0003638_abnormal_response/metabolism_0.83191020
120MP0001963_abnormal_hearing_physiology0.83011910
121MP0001727_abnormal_embryo_implantation0.82621496
122MP0000569_abnormal_digit_pigmentation0.82604490
123MP0000604_amyloidosis0.82111494
124MP0004272_abnormal_basement_membrane0.81680974
125MP0004142_abnormal_muscle_tone0.80050447
126MP0002882_abnormal_neuron_morphology0.79032273
127MP0003300_gastrointestinal_ulcer0.78116793
128MP0005410_abnormal_fertilization0.77880726
129MP0002069_abnormal_eating/drinking_beha0.77231782
130MP0008873_increased_physiological_sensi0.76583322
131MP0002229_neurodegeneration0.75742644
132MP0003632_abnormal_nervous_system0.75409258
133MP0005332_abnormal_amino_acid0.75356470
134MP0006138_congestive_heart_failure0.74486091
135MP0004859_abnormal_synaptic_plasticity0.74321042
136MP0005166_decreased_susceptibility_to0.74303584
137MP0009763_increased_sensitivity_to0.73534910
138MP0002148_abnormal_hypersensitivity_rea0.72788147
139MP0002653_abnormal_ependyma_morphology0.72569635
140MP0002160_abnormal_reproductive_system0.72172564
141MP0002066_abnormal_motor_capabilities/c0.70602026
142MP0002019_abnormal_tumor_incidence0.70376575
143MP0002693_abnormal_pancreas_physiology0.70371265
144MP0009785_altered_susceptibility_to0.70070286
145MP0001177_atelectasis0.69790306
146MP0002166_altered_tumor_susceptibility0.69744917
147MP0005377_hearing/vestibular/ear_phenot0.69284759
148MP0003878_abnormal_ear_physiology0.69284759
149MP0000462_abnormal_digestive_system0.69029183
150MP0003137_abnormal_impulse_conducting0.68617569
151MP0002102_abnormal_ear_morphology0.67380197
152MP0002733_abnormal_thermal_nociception0.67206742
153MP0002876_abnormal_thyroid_physiology0.66604647
154MP0005670_abnormal_white_adipose0.66158423
155MP0001529_abnormal_vocalization0.65732052
156MP0005085_abnormal_gallbladder_physiolo0.65402014
157MP0009764_decreased_sensitivity_to0.63765152
158MP0005000_abnormal_immune_tolerance0.63267055
159MP0001905_abnormal_dopamine_level0.62726422
160MP0009379_abnormal_foot_pigmentation0.62470461
161MP0009643_abnormal_urine_homeostasis0.62160282
162MP0005595_abnormal_vascular_smooth0.60194453
163MP0008260_abnormal_autophagy0.59650818
164MP0000015_abnormal_ear_pigmentation0.59629013
165MP0002752_abnormal_somatic_nervous0.59378000
166MP0006082_CNS_inflammation0.58835983
167MP0005075_abnormal_melanosome_morpholog0.58649497
168MP0000516_abnormal_urinary_system0.58490372
169MP0005367_renal/urinary_system_phenotyp0.58490372
170MP0004130_abnormal_muscle_cell0.58264692
171MP0000249_abnormal_blood_vessel0.58214138
172MP0004924_abnormal_behavior0.56265396
173MP0008007_abnormal_cellular_replicative0.56260580
174MP0002136_abnormal_kidney_physiology0.55568365
175MP0001191_abnormal_skin_condition0.51301909
176MP0003646_muscle_fatigue0.50454518
177MP0001986_abnormal_taste_sensitivity0.50206542
178MP0003111_abnormal_nucleus_morphology0.49895641
179MP0002083_premature_death0.49877887
180MP0001243_abnormal_dermal_layer0.49706000
181MP0005666_abnormal_adipose_tissue0.47800375
182MP0001984_abnormal_olfaction0.45275952

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)8.41466358
2T lymphocytopenia (HP:0005403)8.03259562
3Increased IgM level (HP:0003496)5.94185099
4Autoimmune hemolytic anemia (HP:0001890)5.33320253
5Chronic diarrhea (HP:0002028)5.23750258
6Abnormality of T cells (HP:0002843)5.08091775
7Hypoproteinemia (HP:0003075)4.86399768
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.61697408
9Visual hallucinations (HP:0002367)4.22066374
10Neurofibrillary tangles (HP:0002185)4.10711029
11Severe combined immunodeficiency (HP:0004430)4.07678426
12Abnormality of the prostate (HP:0008775)4.05893641
13Vacuolated lymphocytes (HP:0001922)4.04275865
14Autoimmune thrombocytopenia (HP:0001973)3.99680305
15IgG deficiency (HP:0004315)3.91753320
16Recurrent bronchitis (HP:0002837)3.84503308
17Aplastic anemia (HP:0001915)3.76638805
18Ankle clonus (HP:0011448)3.67203316
19Abnormality of eosinophils (HP:0001879)3.63833533
20Abnormality of the phalanges of the 2nd finger (HP:0009541)3.63532578
21J-shaped sella turcica (HP:0002680)3.63450962
22Hypoplasia of the thymus (HP:0000778)3.60929451
23Absent septum pellucidum (HP:0001331)3.57424640
24Fibular aplasia (HP:0002990)3.45605460
25Ureteral stenosis (HP:0000071)3.40202232
26Abnormality of the corticospinal tract (HP:0002492)3.38543858
27Optic nerve hypoplasia (HP:0000609)3.31156799
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.28611123
29Degeneration of the lateral corticospinal tracts (HP:0002314)3.28611123
30Chronic obstructive pulmonary disease (HP:0006510)3.28597942
31Obstructive lung disease (HP:0006536)3.28597942
32Granulocytopenia (HP:0001913)3.27218550
33Clumsiness (HP:0002312)3.26673013
34Meningitis (HP:0001287)3.25669275
35Abnormality of B cell number (HP:0010975)3.19269622
36Combined immunodeficiency (HP:0005387)3.19029932
37Thyroiditis (HP:0100646)3.15748260
38Ureteral obstruction (HP:0006000)3.13945725
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.13155353
40Vasculitis (HP:0002633)3.13155022
41Hemiparesis (HP:0001269)3.08725007
42Eosinophilia (HP:0001880)3.06341561
43Protruding tongue (HP:0010808)3.05256587
44Abnormality of the septum pellucidum (HP:0007375)3.02388480
45Hyperventilation (HP:0002883)3.01615968
46Recurrent viral infections (HP:0004429)3.00688593
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.99472746
48Stomach cancer (HP:0012126)2.98734822
49Short tibia (HP:0005736)2.92019397
50Chronic mucocutaneous candidiasis (HP:0002728)2.90785485
51Recurrent cutaneous fungal infections (HP:0011370)2.90785485
52Encephalitis (HP:0002383)2.90681471
53Focal motor seizures (HP:0011153)2.90380818
54Recurrent fungal infections (HP:0002841)2.89684967
55Chest pain (HP:0100749)2.89574277
56Hemiplegia (HP:0002301)2.87960991
57IgA deficiency (HP:0002720)2.87519551
58Epileptic encephalopathy (HP:0200134)2.82543873
59Abnormality of T cell physiology (HP:0011840)2.82409546
60Gangrene (HP:0100758)2.80672629
61Pustule (HP:0200039)2.75361241
62Carpal bone hypoplasia (HP:0001498)2.73644882
63Abnormality of binocular vision (HP:0011514)2.72743726
64Diplopia (HP:0000651)2.72743726
65Aplasia/hypoplasia of the uterus (HP:0008684)2.70466717
66Hemoptysis (HP:0002105)2.70162649
67Lymphopenia (HP:0001888)2.69673414
68Axonal loss (HP:0003447)2.69438665
69Gait imbalance (HP:0002141)2.69241176
70Pulmonary infiltrates (HP:0002113)2.68675746
71Leukocytosis (HP:0001974)2.68241975
72Dysmetria (HP:0001310)2.67709347
73Mutism (HP:0002300)2.65352855
74Abnormality of male internal genitalia (HP:0000022)2.64118815
75Abnormal sex determination (HP:0012244)2.62123736
76Sex reversal (HP:0012245)2.62123736
77Termporal pattern (HP:0011008)2.61186670
78Insidious onset (HP:0003587)2.61186670
79Neuronal loss in central nervous system (HP:0002529)2.60577688
80Confusion (HP:0001289)2.59575164
81Adactyly (HP:0009776)2.58594294
82Stomatitis (HP:0010280)2.57717506
83Hyperglycinemia (HP:0002154)2.55738420
84Joint swelling (HP:0001386)2.52680310
85Septo-optic dysplasia (HP:0100842)2.52003164
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51780128
87Cerebral inclusion bodies (HP:0100314)2.50695854
88Lymphoma (HP:0002665)2.50610052
89Hyperglycinuria (HP:0003108)2.49929569
90Hypoplasia of the uterus (HP:0000013)2.49647564
91Absence seizures (HP:0002121)2.48446736
92Myositis (HP:0100614)2.47658821
93Congenital primary aphakia (HP:0007707)2.45464501
94Progressive external ophthalmoplegia (HP:0000590)2.43799051
95Abnormality of the middle phalanges of the toes (HP:0010183)2.39620608
96Hypergammaglobulinemia (HP:0010702)2.36233935
97Chronic hepatic failure (HP:0100626)2.36044614
98Tetraplegia (HP:0002445)2.35379839
99Abnormality of serine family amino acid metabolism (HP:0010894)2.34205595
100Abnormality of glycine metabolism (HP:0010895)2.34205595
101Agammaglobulinemia (HP:0004432)2.31173973
102Elevated erythrocyte sedimentation rate (HP:0003565)2.30488080
103Urinary urgency (HP:0000012)2.30384306
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28880007
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28880007
106Prolonged neonatal jaundice (HP:0006579)2.27295139
107Bronchitis (HP:0012387)2.27079122
1083-Methylglutaconic aciduria (HP:0003535)2.26895067
109Blue irides (HP:0000635)2.25961798
110Synostosis involving the elbow (HP:0003938)2.25551576
111Humeroradial synostosis (HP:0003041)2.25551576
112Drooling (HP:0002307)2.25516643
113Excessive salivation (HP:0003781)2.25516643
114Pulmonary embolism (HP:0002204)2.25246929
115Abnormality of macrophages (HP:0004311)2.23652703
116Abnormality of liposaccharide metabolism (HP:0010968)2.23200678
117Abnormality of glycosphingolipid metabolism (HP:0004343)2.23200678
118Abnormality of glycolipid metabolism (HP:0010969)2.23200678
119Recurrent skin infections (HP:0001581)2.22434158
120Medial flaring of the eyebrow (HP:0010747)2.20607971
121Pulmonary fibrosis (HP:0002206)2.20514707
122Constricted visual fields (HP:0001133)2.20504342
123Duplicated collecting system (HP:0000081)2.19600970
124Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.19243056
125Abnormality of DNA repair (HP:0003254)2.18644753
126Abnormality of the pleura (HP:0002103)2.16424631
127Urinary incontinence (HP:0000020)2.15798957
128Aplasia/Hypoplasia of the spleen (HP:0010451)2.15505870
129Abnormality of the 2nd finger (HP:0004100)2.15180738
130Abnormality of the alveolar ridges (HP:0006477)2.14375125
131Recurrent bacterial skin infections (HP:0005406)2.12385989
132Joint hemorrhage (HP:0005261)2.10241118
133External ophthalmoplegia (HP:0000544)2.09950619
134Retinal dysplasia (HP:0007973)2.09102461
135Type II lissencephaly (HP:0007260)2.08197007
136Abnormality of the common coagulation pathway (HP:0010990)2.08172367
137Optic neuritis (HP:0100653)2.07340084
138Retrobulbar optic neuritis (HP:0100654)2.07340084
139Hypochromic anemia (HP:0001931)2.06179163
140Melanoma (HP:0002861)2.05682223
141Nephrogenic diabetes insipidus (HP:0009806)2.02583790
142Type I transferrin isoform profile (HP:0003642)2.02505078
143Exercise-induced myalgia (HP:0003738)2.00804438
144Recurrent abscess formation (HP:0002722)1.99928659
145Metabolic alkalosis (HP:0200114)1.99629053
146Recurrent otitis media (HP:0000403)1.99444054
147Conical tooth (HP:0000698)1.98983096
148Gaze-evoked nystagmus (HP:0000640)1.98273364
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96910433
150Progressive inability to walk (HP:0002505)1.96793423
151Dislocated radial head (HP:0003083)1.96732652
152Autoamputation (HP:0001218)1.96138859
153Cortical visual impairment (HP:0100704)1.95877548
154Abnormal albumin level (HP:0012116)1.95857673
155Hypoalbuminemia (HP:0003073)1.95857673
156Abnormality of the phalanges of the 5th finger (HP:0004213)1.94972291
157Supranuclear gaze palsy (HP:0000605)1.93698727
158Type I diabetes mellitus (HP:0100651)1.93431316
159Fatigue (HP:0012378)1.91158195
160Abnormality of the radial head (HP:0003995)1.90853982
161Panhypogammaglobulinemia (HP:0003139)1.89762008
162Action tremor (HP:0002345)1.89332433
163Abnormality of the renal collecting system (HP:0004742)1.88961035
164Hypercortisolism (HP:0001578)1.88616570
165Focal seizures (HP:0007359)1.88552499
166Restlessness (HP:0000711)1.87572982
167Clonus (HP:0002169)1.87530119
168Symphalangism affecting the phalanges of the hand (HP:0009773)1.87093701
169Skin rash (HP:0000988)1.86846537
170Periorbital edema (HP:0100539)1.86001699
171True hermaphroditism (HP:0010459)1.84859911
172Abnormal auditory evoked potentials (HP:0006958)1.83957845
173Broad-based gait (HP:0002136)1.82917864
174Prolonged partial thromboplastin time (HP:0003645)1.81410594
175Agitation (HP:0000713)1.81208609
176Facial edema (HP:0000282)1.80941896
177Neuroendocrine neoplasm (HP:0100634)1.79878059
178Mediastinal lymphadenopathy (HP:0100721)1.79338346
179Zonular cataract (HP:0010920)1.78994401
180Glomerulopathy (HP:0100820)1.77872391
181Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77795971
182Abnormal pancreas size (HP:0012094)1.77693638
183Dialeptic seizures (HP:0011146)1.77523086
184Progressive cerebellar ataxia (HP:0002073)1.76281944
185Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75674919
186Peripheral demyelination (HP:0011096)1.75337280
187Generalized myoclonic seizures (HP:0002123)1.75055692
188Dyschromatopsia (HP:0007641)1.74949696
189Anhidrosis (HP:0000970)1.74907636
190Abnormality of salivation (HP:0100755)1.73451284
191Hyperinsulinemic hypoglycemia (HP:0000825)1.72883703
192Orchitis (HP:0100796)1.71659266
193Leiomyosarcoma (HP:0100243)1.71095014
194Uterine leiomyosarcoma (HP:0002891)1.71095014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.74484661
2CASK5.34713356
3CLK14.54276375
4KDR3.83982225
5STK393.75783476
6MAP4K13.05045772
7ITK2.79611102
8GRK72.64341083
9BMX2.60532519
10MAPKAPK52.51582195
11FES2.44423275
12NME12.33514918
13ZAP702.21799066
14MAPK152.08513021
15SYK1.95214984
16IRAK21.94586923
17WNK41.84002387
18EPHA41.80004789
19OXSR11.78113797
20TEC1.72176612
21UHMK11.69178211
22MAP3K121.61848141
23ADRBK21.60169060
24IRAK11.59369771
25TNIK1.57583057
26LCK1.56763029
27TYRO31.56573793
28CAMK1D1.55432501
29MAP3K141.44029332
30FGR1.43555350
31MAPK131.37965623
32IRAK41.37286575
33FRK1.34656871
34GRK11.33645782
35MAPKAPK31.33021279
36TRIM281.30732735
37MATK1.27133690
38BCKDK1.26874545
39ZAK1.25690165
40BTK1.21541772
41PDGFRB1.21492595
42PBK1.18834094
43TBK11.18603797
44MAPK121.17083609
45DAPK11.14055071
46WNK11.11952583
47BLK1.11883957
48RIPK41.04662519
49TRPM71.03337713
50VRK21.02019164
51HIPK21.01896866
52TAOK30.98617646
53PIM20.97697668
54PRKCE0.97080000
55EPHB10.96647617
56CAMK1G0.96527864
57IRAK30.95083785
58MAP3K100.94261055
59CSF1R0.92964118
60JAK20.88524801
61NEK90.85861639
62LYN0.84854996
63EEF2K0.82125536
64ALK0.80896223
65PDK20.78544964
66NEK10.77344077
67WNK30.76234662
68IKBKB0.74365655
69BMPR20.73042483
70SMG10.72990514
71EPHA30.72345842
72DYRK30.71683908
73JAK10.69968914
74CAMK2B0.69366180
75PHKG20.67539093
76PHKG10.67539093
77TESK20.66914640
78BCR0.66242341
79MET0.66188278
80IKBKE0.65077001
81CAMKK10.64663550
82NTRK30.64158425
83SGK4940.63141761
84SGK2230.63141761
85CAMK2A0.63069920
86MAP3K70.63000476
87PINK10.62609986
88PDK10.61198823
89DAPK20.58893933
90NTRK10.58141882
91GRK60.58072015
92PIK3CG0.57537023
93PRPF4B0.57160397
94NUAK10.55192249
95MYLK0.55180534
96MAPK40.54446675
97MAP2K20.53868209
98TXK0.53830194
99TYK20.53679550
100MAPKAPK20.52450611
101VRK10.51302372
102ARAF0.50720684
103EIF2AK30.50579844
104TGFBR20.49602963
105PRKCQ0.48347984
106CDK190.48091994
107PIM10.47946405
108CDK30.47224632
109BUB10.47033012
110PRKD20.47027878
111MAPK30.45101841
112YES10.44951433
113MAPK110.44380978
114EIF2AK20.44373447
115CDK50.43912277
116NLK0.43688670
117SGK20.43632016
118GRK50.41380025
119TSSK60.41231832
120MST40.40633361
121SGK10.39851104
122HCK0.39310755
123MAPK70.39032536
124PASK0.37221112
125RPS6KA50.36429477
126PRKCG0.35981936
127CAMK2D0.35822975
128JAK30.35749883
129MST1R0.34244162
130CSK0.33816385
131RET0.33522398
132PIK3CA0.32030446
133MARK10.29936682
134MKNK10.29623788
135MAP3K110.29540224
136IGF1R0.27536853
137PRKACA0.27293775
138ROCK20.26739143
139CAMK2G0.26590957
140CAMK10.25055193
141ROCK10.24439444
142NME20.24421856
143LMTK20.24274433
144MAP2K60.24252686
145GSK3A0.24199823
146ADRBK10.24199204
147PRKCD0.24164197
148MELK0.23321321
149INSR0.23227689
150DDR20.22640860
151FGFR20.22506430
152PDPK10.22185109
153MARK30.21656437
154CSNK1A10.21577320
155FYN0.21168274
156PRKCA0.20601721
157MAPK90.20330584
158MAP3K50.20290757
159STK100.19948014
160ABL10.19657666
161PKN10.19320297
162BMPR1B0.17531412
163NTRK20.16975002

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.78996188
2Autoimmune thyroid disease_Homo sapiens_hsa053204.36444782
3Allograft rejection_Homo sapiens_hsa053303.87652815
4Hematopoietic cell lineage_Homo sapiens_hsa046403.85663025
5T cell receptor signaling pathway_Homo sapiens_hsa046603.35651257
6Steroid biosynthesis_Homo sapiens_hsa001003.19810491
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.93144694
8Antigen processing and presentation_Homo sapiens_hsa046122.62209454
9Ether lipid metabolism_Homo sapiens_hsa005652.60379953
10Nitrogen metabolism_Homo sapiens_hsa009102.57721958
11Sulfur metabolism_Homo sapiens_hsa009202.30793045
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26611100
13Rheumatoid arthritis_Homo sapiens_hsa053232.24737161
14Fatty acid elongation_Homo sapiens_hsa000622.17213931
15Sphingolipid metabolism_Homo sapiens_hsa006002.13701130
16Nicotine addiction_Homo sapiens_hsa050332.11479503
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.09358402
18Measles_Homo sapiens_hsa051621.96907442
19Salivary secretion_Homo sapiens_hsa049701.87280078
20GABAergic synapse_Homo sapiens_hsa047271.83737211
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82451847
22Proteasome_Homo sapiens_hsa030501.81729102
23Morphine addiction_Homo sapiens_hsa050321.78786644
24Histidine metabolism_Homo sapiens_hsa003401.78641948
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77975612
26Dorso-ventral axis formation_Homo sapiens_hsa043201.76682164
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72584718
28Viral myocarditis_Homo sapiens_hsa054161.72528738
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72175140
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72026286
31Fatty acid biosynthesis_Homo sapiens_hsa000611.70583056
32Pancreatic secretion_Homo sapiens_hsa049721.69404491
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66385695
34Asthma_Homo sapiens_hsa053101.62924414
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61436074
36Other glycan degradation_Homo sapiens_hsa005111.58920035
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.56856409
38Gastric acid secretion_Homo sapiens_hsa049711.51409970
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50776277
40Type I diabetes mellitus_Homo sapiens_hsa049401.47995472
41Glutamatergic synapse_Homo sapiens_hsa047241.45793461
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45043159
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43213968
44Bile secretion_Homo sapiens_hsa049761.41601926
45Circadian entrainment_Homo sapiens_hsa047131.34547674
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33897299
47Chemokine signaling pathway_Homo sapiens_hsa040621.33107078
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.33092178
49Leishmaniasis_Homo sapiens_hsa051401.22991746
50Arginine and proline metabolism_Homo sapiens_hsa003301.22608744
51Taste transduction_Homo sapiens_hsa047421.21474170
52Insulin secretion_Homo sapiens_hsa049111.21462401
53Vitamin digestion and absorption_Homo sapiens_hsa049771.19306728
54Propanoate metabolism_Homo sapiens_hsa006401.18529013
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16771054
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13231723
57Herpes simplex infection_Homo sapiens_hsa051681.11608541
58TNF signaling pathway_Homo sapiens_hsa046681.10241633
59Protein export_Homo sapiens_hsa030601.06843496
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05977560
61Long-term depression_Homo sapiens_hsa047301.03908820
62Malaria_Homo sapiens_hsa051441.03706949
63PPAR signaling pathway_Homo sapiens_hsa033200.99677162
64beta-Alanine metabolism_Homo sapiens_hsa004100.97011337
65Apoptosis_Homo sapiens_hsa042100.94874988
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94663331
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93554658
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92198933
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.91918858
70Peroxisome_Homo sapiens_hsa041460.89259984
71Folate biosynthesis_Homo sapiens_hsa007900.87866148
72Staphylococcus aureus infection_Homo sapiens_hsa051500.87024005
73Cocaine addiction_Homo sapiens_hsa050300.85783463
74Osteoclast differentiation_Homo sapiens_hsa043800.84795744
75Linoleic acid metabolism_Homo sapiens_hsa005910.83121131
76Ovarian steroidogenesis_Homo sapiens_hsa049130.82885071
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82502816
78HTLV-I infection_Homo sapiens_hsa051660.82366933
79Serotonergic synapse_Homo sapiens_hsa047260.82130023
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80910601
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78936782
82Synaptic vesicle cycle_Homo sapiens_hsa047210.75337593
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74565018
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74564476
85Influenza A_Homo sapiens_hsa051640.74123079
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72683923
87Pertussis_Homo sapiens_hsa051330.72052185
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69333068
89Epstein-Barr virus infection_Homo sapiens_hsa051690.68739193
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68270784
91Lysosome_Homo sapiens_hsa041420.67683424
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.66482423
93Melanogenesis_Homo sapiens_hsa049160.66102885
94Phagosome_Homo sapiens_hsa041450.65094735
95Mineral absorption_Homo sapiens_hsa049780.64798865
96Fatty acid metabolism_Homo sapiens_hsa012120.64491891
97Calcium signaling pathway_Homo sapiens_hsa040200.64330078
98Shigellosis_Homo sapiens_hsa051310.64325983
99Collecting duct acid secretion_Homo sapiens_hsa049660.63984009
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63939103
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61898899
102Tight junction_Homo sapiens_hsa045300.60751586
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60659904
104African trypanosomiasis_Homo sapiens_hsa051430.59306034
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.58939285
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56566854
107Legionellosis_Homo sapiens_hsa051340.55775734
108Parkinsons disease_Homo sapiens_hsa050120.55195727
109Thyroid hormone synthesis_Homo sapiens_hsa049180.52866910
110B cell receptor signaling pathway_Homo sapiens_hsa046620.50612842
111Arginine biosynthesis_Homo sapiens_hsa002200.49987070
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49440174
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49375216
114Fatty acid degradation_Homo sapiens_hsa000710.48344966
115Renin secretion_Homo sapiens_hsa049240.48092164
116Prion diseases_Homo sapiens_hsa050200.47520796
117Vibrio cholerae infection_Homo sapiens_hsa051100.47091067
118Oxidative phosphorylation_Homo sapiens_hsa001900.46589824
119ABC transporters_Homo sapiens_hsa020100.46381257
120Olfactory transduction_Homo sapiens_hsa047400.46089174
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45798185
122Cholinergic synapse_Homo sapiens_hsa047250.45795818
123Salmonella infection_Homo sapiens_hsa051320.45681770
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44968624
125Protein digestion and absorption_Homo sapiens_hsa049740.44764143
126Fructose and mannose metabolism_Homo sapiens_hsa000510.44298378
127Tuberculosis_Homo sapiens_hsa051520.43521139
128Graft-versus-host disease_Homo sapiens_hsa053320.43099716
129Butanoate metabolism_Homo sapiens_hsa006500.42733804
130Hepatitis C_Homo sapiens_hsa051600.39086384
131Basal cell carcinoma_Homo sapiens_hsa052170.39015353
132Tryptophan metabolism_Homo sapiens_hsa003800.38453396
133Amphetamine addiction_Homo sapiens_hsa050310.37656884
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.36880328
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36553043
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35865638
137p53 signaling pathway_Homo sapiens_hsa041150.32906873
138Systemic lupus erythematosus_Homo sapiens_hsa053220.32644621
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.32378118
140Toxoplasmosis_Homo sapiens_hsa051450.29955529
141Fanconi anemia pathway_Homo sapiens_hsa034600.28512016
142Phototransduction_Homo sapiens_hsa047440.26783514
143Alzheimers disease_Homo sapiens_hsa050100.24486652
144Hepatitis B_Homo sapiens_hsa051610.22139605
145RNA polymerase_Homo sapiens_hsa030200.22053293
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.22004121
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21398792
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21217119
149Glioma_Homo sapiens_hsa052140.19343245
150Thyroid cancer_Homo sapiens_hsa052160.18635234
151Chronic myeloid leukemia_Homo sapiens_hsa052200.18526572
152Non-small cell lung cancer_Homo sapiens_hsa052230.18442780
153Endocytosis_Homo sapiens_hsa041440.13661796
154Regulation of autophagy_Homo sapiens_hsa041400.13088611
155Ras signaling pathway_Homo sapiens_hsa040140.12541777
156Retinol metabolism_Homo sapiens_hsa008300.11739656
157Arachidonic acid metabolism_Homo sapiens_hsa005900.07561701
158Pyrimidine metabolism_Homo sapiens_hsa002400.04307705
159Alcoholism_Homo sapiens_hsa050340.02966310
160MAPK signaling pathway_Homo sapiens_hsa040100.02823610
161Caffeine metabolism_Homo sapiens_hsa00232-0.0547013
162Mismatch repair_Homo sapiens_hsa03430-0.0494441
163Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0442917
164Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0352404
165Type II diabetes mellitus_Homo sapiens_hsa04930-0.0334786
166Viral carcinogenesis_Homo sapiens_hsa05203-0.0157222
167Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0042208

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