TREH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.85985718
2angiotensin maturation (GO:0002003)8.76989235
3intestinal cholesterol absorption (GO:0030299)8.46816136
4drug catabolic process (GO:0042737)7.25668637
5drug transmembrane transport (GO:0006855)6.99452969
6regulation of guanylate cyclase activity (GO:0031282)6.55881306
7drug transport (GO:0015893)6.47391328
8regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.10816128
9urate metabolic process (GO:0046415)6.02050828
10flavonoid metabolic process (GO:0009812)5.95761530
11fat-soluble vitamin biosynthetic process (GO:0042362)5.77631090
12exogenous drug catabolic process (GO:0042738)5.51481973
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.50854915
14modified amino acid transport (GO:0072337)5.43064870
15positive regulation of guanylate cyclase activity (GO:0031284)5.36516243
16lysine metabolic process (GO:0006553)5.20065177
17lysine catabolic process (GO:0006554)5.20065177
18peptide catabolic process (GO:0043171)5.17514617
19hormone catabolic process (GO:0042447)5.12353828
20cysteine metabolic process (GO:0006534)5.01807325
21vitamin A metabolic process (GO:0006776)4.97309793
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.97282628
23alkaloid metabolic process (GO:0009820)4.89898856
24organic cation transport (GO:0015695)4.74682148
25virion attachment to host cell (GO:0019062)4.60766894
26adhesion of symbiont to host cell (GO:0044650)4.60766894
27regulation of triglyceride catabolic process (GO:0010896)4.59588485
28positive regulation of lipoprotein lipase activity (GO:0051006)4.59433091
29positive regulation of triglyceride lipase activity (GO:0061365)4.59433091
30regulation of cGMP biosynthetic process (GO:0030826)4.54085453
31energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50349176
32ATP synthesis coupled proton transport (GO:0015986)4.50349176
33phospholipid efflux (GO:0033700)4.45789532
34regulation of cholesterol esterification (GO:0010872)4.42509431
35actin filament depolymerization (GO:0030042)4.40286831
36response to phenylpropanoid (GO:0080184)4.36929577
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35175258
38regulation of systemic arterial blood pressure by hormone (GO:0001990)4.31955972
39regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.31955972
40endocrine process (GO:0050886)4.31955972
41regulation of bile acid biosynthetic process (GO:0070857)4.25647900
42regulation of systemic arterial blood pressure (GO:0003073)4.24982508
43phosphate ion transport (GO:0006817)4.24490287
44aminoglycoside antibiotic metabolic process (GO:0030647)4.21913009
45plasma lipoprotein particle assembly (GO:0034377)4.18979628
46lipoprotein metabolic process (GO:0042157)4.18815164
47NADH metabolic process (GO:0006734)4.16941176
48renal absorption (GO:0070293)4.13278254
49nonribosomal peptide biosynthetic process (GO:0019184)4.09058272
50viral transcription (GO:0019083)4.08712825
51glucose 6-phosphate metabolic process (GO:0051156)4.06695381
52glyoxylate metabolic process (GO:0046487)4.06231950
533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.05050030
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.05050030
55protein-lipid complex assembly (GO:0065005)4.03687876
56fructose metabolic process (GO:0006000)4.02132417
57regulation of cGMP metabolic process (GO:0030823)4.01700450
58bile acid and bile salt transport (GO:0015721)3.99459436
59negative regulation of cholesterol transport (GO:0032375)3.96817013
60negative regulation of sterol transport (GO:0032372)3.96817013
61drug metabolic process (GO:0017144)3.96655135
62sulfation (GO:0051923)3.95037631
63glutathione biosynthetic process (GO:0006750)3.94729413
64vitamin biosynthetic process (GO:0009110)3.93990594
65glomerulus development (GO:0032835)3.93015037
66homocysteine metabolic process (GO:0050667)3.91333394
67polyol transport (GO:0015791)3.85118768
68translational termination (GO:0006415)3.84994265
69cholesterol efflux (GO:0033344)3.84196843
70sterol homeostasis (GO:0055092)3.84123450
71quaternary ammonium group transport (GO:0015697)3.84082183
72cholesterol homeostasis (GO:0042632)3.81620071
73adhesion of symbiont to host (GO:0044406)3.78256301
74regulation of cholesterol homeostasis (GO:2000188)3.78098705
75lipoprotein transport (GO:0042953)3.78010707
76phosphate ion transmembrane transport (GO:0035435)3.72953790
77transepithelial transport (GO:0070633)3.70317599
78positive regulation of cGMP biosynthetic process (GO:0030828)3.69929256
79establishment of protein localization to mitochondrial membrane (GO:0090151)3.67509809
80very-low-density lipoprotein particle assembly (GO:0034379)3.67358695
81diacylglycerol metabolic process (GO:0046339)3.67035279
82sulfur compound transport (GO:0072348)3.65870888
83digestive system process (GO:0022600)3.64309628
84respiratory electron transport chain (GO:0022904)3.62974199
85epoxygenase P450 pathway (GO:0019373)3.58275308
86electron transport chain (GO:0022900)3.58052794
87excretion (GO:0007588)3.54427990
88behavioral response to nicotine (GO:0035095)3.54010996
89beta-amyloid metabolic process (GO:0050435)3.50649353
90vitamin D metabolic process (GO:0042359)3.50362429
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.49229141
92sulfate transmembrane transport (GO:1902358)3.48013072
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46976273
94negative regulation of digestive system process (GO:0060457)3.46721797
95amino-acid betaine metabolic process (GO:0006577)3.44882599
96peptide biosynthetic process (GO:0043043)3.43940931
97positive regulation of cGMP metabolic process (GO:0030825)3.41632165
98fat-soluble vitamin metabolic process (GO:0006775)3.41267056
99aspartate family amino acid catabolic process (GO:0009068)3.40960750
100cellular glucuronidation (GO:0052695)3.40938937
101vitamin transport (GO:0051180)3.40386561
102peptide hormone processing (GO:0016486)3.38894443
103cGMP-mediated signaling (GO:0019934)3.38145414
104renal system process involved in regulation of blood volume (GO:0001977)3.38004879
105reverse cholesterol transport (GO:0043691)3.36135588
106receptor guanylyl cyclase signaling pathway (GO:0007168)3.36065762
107phosphate ion homeostasis (GO:0055062)3.35991166
108trivalent inorganic anion homeostasis (GO:0072506)3.35991166
109glutathione derivative biosynthetic process (GO:1901687)3.34434589
110glutathione derivative metabolic process (GO:1901685)3.34434589
111positive regulation of fatty acid biosynthetic process (GO:0045723)3.33959859
112cobalamin metabolic process (GO:0009235)3.32355623
113cellular modified amino acid catabolic process (GO:0042219)3.32091555
114uronic acid metabolic process (GO:0006063)3.32076583
115glucuronate metabolic process (GO:0019585)3.32076583
116* digestion (GO:0007586)3.29345221
117urea cycle (GO:0000050)3.26555751
118urea metabolic process (GO:0019627)3.26555751
119neurotransmitter catabolic process (GO:0042135)3.24708663
120glycerol metabolic process (GO:0006071)3.23521618
121L-phenylalanine metabolic process (GO:0006558)3.23124177
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23124177
123response to hydroperoxide (GO:0033194)3.22690199
124phenylpropanoid metabolic process (GO:0009698)3.21046479
125nucleobase catabolic process (GO:0046113)3.20985071
126sequestering of actin monomers (GO:0042989)3.19857065
127cGMP biosynthetic process (GO:0006182)3.19666798
128amino-acid betaine transport (GO:0015838)3.19308826
129carnitine transport (GO:0015879)3.19308826
130tricarboxylic acid metabolic process (GO:0072350)3.18539150
131short-chain fatty acid metabolic process (GO:0046459)3.16228753
132response to hepatocyte growth factor (GO:0035728)3.16027370
133cellular response to hepatocyte growth factor stimulus (GO:0035729)3.16027370
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15901052
135L-phenylalanine catabolic process (GO:0006559)3.15901052
136alditol metabolic process (GO:0019400)3.15272132
137fatty acid beta-oxidation (GO:0006635)3.14241071
138heme transport (GO:0015886)3.09416647
139cotranslational protein targeting to membrane (GO:0006613)3.01654817
140protein targeting to ER (GO:0045047)3.01364485
141cellular protein complex disassembly (GO:0043624)2.99068068
142SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97582905
143phenol-containing compound catabolic process (GO:0019336)2.96851867
144calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.95209979
145translational elongation (GO:0006414)2.90704075
146positive regulation of respiratory burst (GO:0060267)2.90388460
147positive regulation of lipid catabolic process (GO:0050996)2.90340637
148antibacterial humoral response (GO:0019731)2.89389637
149dopamine biosynthetic process (GO:0042416)2.89130907
150viral life cycle (GO:0019058)2.87302173
151regulation of cellular extravasation (GO:0002691)2.86571643
152arginine metabolic process (GO:0006525)2.85220499
153positive regulation of gastrulation (GO:2000543)2.84581823
154ribosomal small subunit biogenesis (GO:0042274)2.84354953
155establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83980453
156otic vesicle formation (GO:0030916)2.83153640
157response to histamine (GO:0034776)2.81637713
158serotonin metabolic process (GO:0042428)2.81559505
159vitamin transmembrane transport (GO:0035461)2.80636798
160L-ascorbic acid metabolic process (GO:0019852)2.80475289
161negative regulation of epidermal cell differentiation (GO:0045605)2.79648846
162protein localization to endoplasmic reticulum (GO:0070972)2.78776719
163antimicrobial humoral response (GO:0019730)2.77423535
164positive regulation of fatty acid oxidation (GO:0046321)2.68004042
165quinone biosynthetic process (GO:1901663)2.63179260
166cellular response to nitric oxide (GO:0071732)2.62637700
167dopaminergic neuron differentiation (GO:0071542)2.59535729
168regulation of vitamin metabolic process (GO:0030656)2.58709073
169neuron fate determination (GO:0048664)2.55663791
170fat-soluble vitamin catabolic process (GO:0042363)2.54915767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.68294782
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.23067681
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.60418421
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.36604514
5CDX2_20551321_ChIP-Seq_CACO-2_Human4.35736211
6EZH2_22144423_ChIP-Seq_EOC_Human4.28697058
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.04050605
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47547789
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26422067
10* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.11750860
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.97504139
12* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.69091301
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63683315
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54737367
15GATA4_25053715_ChIP-Seq_YYC3_Human2.52342990
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42137535
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.38146176
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.33670730
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.27199563
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19263850
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17770817
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13466330
23GATA6_25053715_ChIP-Seq_YYC3_Human2.11212048
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.10700979
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00629770
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.99487948
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95437515
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92002541
29SOX2_20726797_ChIP-Seq_SW620_Human1.90978679
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90457136
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89982820
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89575388
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89575388
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.89308459
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88623363
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85782942
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83146336
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82441345
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81802637
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80786990
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80469270
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79141276
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78570710
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78436290
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.77314679
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76523266
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72390361
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69686396
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.69560919
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69558429
51CLOCK_20551151_ChIP-Seq_293T_Human1.65425702
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63184685
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.59233101
54RXR_22108803_ChIP-Seq_LS180_Human1.55143022
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54422412
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52364827
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52115889
58FUS_26573619_Chip-Seq_HEK293_Human1.51150704
59P300_19829295_ChIP-Seq_ESCs_Human1.50295285
60BCAT_22108803_ChIP-Seq_LS180_Human1.50131155
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45653189
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45653189
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43700300
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.37825196
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37824643
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37449569
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34969883
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33522850
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.32980827
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32628066
71RACK7_27058665_Chip-Seq_MCF-7_Human1.32618021
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32372799
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32329047
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.32061863
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.31978721
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31526034
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31522606
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.28693651
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28256797
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27004679
81REST_21632747_ChIP-Seq_MESCs_Mouse1.26967742
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26950611
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.26912738
84GATA2_19941826_ChIP-Seq_K562_Human1.24637246
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24474398
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23857400
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23628735
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22437209
89GATA1_22025678_ChIP-Seq_K562_Human1.22367132
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19185363
91AR_21909140_ChIP-Seq_LNCAP_Human1.18854175
92TAF15_26573619_Chip-Seq_HEK293_Human1.18776005
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16847008
94AR_25329375_ChIP-Seq_VCAP_Human1.15890324
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14360283
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14192157
97RNF2_27304074_Chip-Seq_NSC_Mouse1.12614671
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12329276
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12178089
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11866480
101VDR_22108803_ChIP-Seq_LS180_Human1.11755799
102LXR_22292898_ChIP-Seq_THP-1_Human1.10935556
103KLF5_25053715_ChIP-Seq_YYC3_Human1.09585653
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09331597
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09068116
106EGR1_19032775_ChIP-ChIP_M12_Human1.08114123
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07780781
108TP53_20018659_ChIP-ChIP_R1E_Mouse1.07358055
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07168855
110* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06321679
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04486794
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.04052784
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02956656
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00166467
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.00057353
116ATF3_27146783_Chip-Seq_COLON_Human0.99996651
117EWS_26573619_Chip-Seq_HEK293_Human0.99284686
118GBX2_23144817_ChIP-Seq_PC3_Human0.98606442
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96665232
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96638117
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.96528717
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95725246
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95711509
124TP53_18474530_ChIP-ChIP_U2OS_Human0.95332537
125NANOG_20526341_ChIP-Seq_ESCs_Human0.94525751
126ZNF274_21170338_ChIP-Seq_K562_Hela0.94523525
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94201960
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94127243
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93297659
130CREB1_26743006_Chip-Seq_LNCaP_Human0.93049100
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92159155
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92113441
133TCF4_22108803_ChIP-Seq_LS180_Human0.91480457
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90583086
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.90413924
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90209996
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90173694
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.89804971
139DROSHA_22980978_ChIP-Seq_HELA_Human0.89427013
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88847374
141* SMAD3_21741376_ChIP-Seq_HESCs_Human0.88049710
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87837895
143MYC_19829295_ChIP-Seq_ESCs_Human0.87379590
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86962711
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.86673790
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86543442
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85855783
148NCOR_22424771_ChIP-Seq_293T_Human0.85781842
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85508476
150CBP_20019798_ChIP-Seq_JUKART_Human0.85389841
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85389841
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84846010
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84603538
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83856514
155NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83822701
156* TP63_23658742_ChIP-Seq_EP156T_Human0.83413981
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82326441
158GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80609460
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80253729
160* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80098445
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79098325
162THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78883190
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77376435
164GATA1_19941826_ChIP-Seq_K562_Human0.76104101
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75812198
166MYC_19915707_ChIP-ChIP_AK7_Human0.75377371
167STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73831905
168JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73495914
169CDX2_22108803_ChIP-Seq_LS180_Human0.73246499
170RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72945862
171EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72565456
172SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72216628
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.71888568
174STAT1_17558387_ChIP-Seq_HELA_Human0.71475518
175P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70813263
176IRF8_22096565_ChIP-ChIP_GC-B_Human0.70187478
177PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69990777
178* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69608044
179* CTCF_27219007_Chip-Seq_Bcells_Human0.69323638
180ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68993327
181EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68643447
182BCOR_27268052_Chip-Seq_Bcells_Human0.67765178
183GATA1_19941827_ChIP-Seq_MEL_Mouse0.67341548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.58010417
2MP0002139_abnormal_hepatobiliary_system5.63576763
3* MP0001666_abnormal_nutrient_absorption4.27958659
4MP0008875_abnormal_xenobiotic_pharmacok4.09055539
5MP0004043_abnormal_pH_regulation3.91730149
6MP0003252_abnormal_bile_duct3.64674897
7MP0004019_abnormal_vitamin_homeostasis3.63911790
8MP0005085_abnormal_gallbladder_physiolo3.59779666
9MP0009840_abnormal_foam_cell3.43743100
10MP0005332_abnormal_amino_acid3.15774287
11MP0003136_yellow_coat_color2.86294759
12MP0005365_abnormal_bile_salt2.67729857
13MP0003183_abnormal_peptide_metabolism2.54898986
14MP0010329_abnormal_lipoprotein_level2.52424384
15MP0009643_abnormal_urine_homeostasis2.39713244
16MP0004264_abnormal_extraembryonic_tissu2.33612373
17MP0010234_abnormal_vibrissa_follicle2.28405172
18MP0000566_synostosis2.26411445
19MP0003878_abnormal_ear_physiology2.19193856
20MP0005377_hearing/vestibular/ear_phenot2.19193856
21MP0005084_abnormal_gallbladder_morpholo2.04466581
22MP0001188_hyperpigmentation2.00297326
23MP0005360_urolithiasis10.4827089
24MP0001765_abnormal_ion_homeostasis1.94775739
25MP0004147_increased_porphyrin_level1.84463700
26MP0002277_abnormal_respiratory_mucosa1.82444502
27MP0001986_abnormal_taste_sensitivity1.81263508
28MP0002138_abnormal_hepatobiliary_system1.74211298
29MP0005636_abnormal_mineral_homeostasis1.73155484
30MP0000538_abnormal_urinary_bladder1.67577418
31MP0000462_abnormal_digestive_system1.66117537
32MP0001485_abnormal_pinna_reflex1.63929153
33MP0003806_abnormal_nucleotide_metabolis1.62963795
34MP0002136_abnormal_kidney_physiology1.62432921
35MP0003191_abnormal_cellular_cholesterol1.60837516
36MP0003868_abnormal_feces_composition1.59050034
37MP0003866_abnormal_defecation1.58837399
38MP0006292_abnormal_olfactory_placode1.52199364
39MP0002735_abnormal_chemical_nociception1.51503804
40MP0001756_abnormal_urination1.50310695
41MP0004133_heterotaxia1.46638920
42MP0003195_calcinosis1.46002825
43MP0003315_abnormal_perineum_morphology1.43183630
44MP0005409_darkened_coat_color1.40778355
45MP0001968_abnormal_touch/_nociception1.39660556
46MP0003938_abnormal_ear_development1.39209040
47MP0003300_gastrointestinal_ulcer1.35680844
48MP0000049_abnormal_middle_ear1.33798859
49MP0002118_abnormal_lipid_homeostasis1.32569818
50MP0002089_abnormal_postnatal_growth/wei1.28309250
51MP0005319_abnormal_enzyme/_coenzyme1.23428579
52MP0001440_abnormal_grooming_behavior1.22892242
53MP0005584_abnormal_enzyme/coenzyme_acti1.21820811
54MP0002938_white_spotting1.20214521
55MP0002736_abnormal_nociception_after1.19732881
56MP0002272_abnormal_nervous_system1.18220457
57MP0003011_delayed_dark_adaptation1.17794949
58MP0002822_catalepsy1.17392877
59MP0001501_abnormal_sleep_pattern1.17174008
60MP0000609_abnormal_liver_physiology1.15275860
61MP0001764_abnormal_homeostasis1.14812930
62MP0003705_abnormal_hypodermis_morpholog1.14763134
63MP0002733_abnormal_thermal_nociception1.12425623
64MP0002734_abnormal_mechanical_nocicepti1.11924493
65MP0002796_impaired_skin_barrier1.11865117
66MP0000026_abnormal_inner_ear1.11033415
67MP0004742_abnormal_vestibular_system1.09899452
68MP0001905_abnormal_dopamine_level1.08646722
69MP0001663_abnormal_digestive_system1.07199827
70MP0005381_digestive/alimentary_phenotyp1.06395759
71MP0005451_abnormal_body_composition1.05776970
72MP0001664_abnormal_digestion1.04572893
73MP0005174_abnormal_tail_pigmentation1.04545260
74MP0000631_abnormal_neuroendocrine_gland1.01621775
75MP0002876_abnormal_thyroid_physiology0.99709900
76MP0002064_seizures0.99063032
77MP0003119_abnormal_digestive_system0.95811757
78MP0001970_abnormal_pain_threshold0.94309955
79MP0005448_abnormal_energy_balance0.94042034
80MP0009745_abnormal_behavioral_response0.93421052
81MP0001486_abnormal_startle_reflex0.90050229
82MP0002638_abnormal_pupillary_reflex0.89572411
83MP0002249_abnormal_larynx_morphology0.89434419
84MP0002254_reproductive_system_inflammat0.87778545
85MP0009780_abnormal_chondrocyte_physiolo0.85857053
86MP0005410_abnormal_fertilization0.85261671
87MP0000537_abnormal_urethra_morphology0.81241424
88MP0008961_abnormal_basal_metabolism0.80751949
89MP0004510_myositis0.80659064
90MP0000477_abnormal_intestine_morphology0.80242669
91MP0009697_abnormal_copulation0.79674001
92MP0000230_abnormal_systemic_arterial0.79545653
93MP0004885_abnormal_endolymph0.78665551
94MP0003638_abnormal_response/metabolism_0.76623516
95MP0005645_abnormal_hypothalamus_physiol0.76286470
96MP0009642_abnormal_blood_homeostasis0.76202795
97MP0010155_abnormal_intestine_physiology0.75412356
98MP0005187_abnormal_penis_morphology0.75374384
99MP0005670_abnormal_white_adipose0.75284823
100MP0003283_abnormal_digestive_organ0.74256779
101MP0002557_abnormal_social/conspecific_i0.74155166
102MP0001293_anophthalmia0.73847616
103MP0009250_abnormal_appendicular_skeleto0.72396112
104MP0002069_abnormal_eating/drinking_beha0.69733542
105MP0001958_emphysema0.69528626
106MP0009764_decreased_sensitivity_to0.68877251
107MP0005058_abnormal_lysosome_morphology0.68539168
108MP0002572_abnormal_emotion/affect_behav0.68334211
109MP0002067_abnormal_sensory_capabilities0.68057399
110MP0001879_abnormal_lymphatic_vessel0.67883872
111MP0009765_abnormal_xenobiotic_induced0.67769742
112MP0000778_abnormal_nervous_system0.67531514
113MP0001873_stomach_inflammation0.66931492
114MP0005266_abnormal_metabolism0.66785725
115MP0005501_abnormal_skin_physiology0.66150094
116MP0006054_spinal_hemorrhage0.63539186
117MP0002098_abnormal_vibrissa_morphology0.61531281
118MP0000604_amyloidosis0.60177634
119MP0003879_abnormal_hair_cell0.59884063
120MP0005167_abnormal_blood-brain_barrier0.59639084
121MP0005376_homeostasis/metabolism_phenot0.57984367
122MP0009053_abnormal_anal_canal0.57490537
123MP0010352_gastrointestinal_tract_polyps0.57465467
124MP0009384_cardiac_valve_regurgitation0.57136368
125MP0003718_maternal_effect0.56679139
126MP0005166_decreased_susceptibility_to0.56175859
127MP0000598_abnormal_liver_morphology0.56013267
128MP0000467_abnormal_esophagus_morphology0.54748565
129MP0008872_abnormal_physiological_respon0.54631352
130MP0008469_abnormal_protein_level0.52667859
131MP0005535_abnormal_body_temperature0.52297150
132MP0004270_analgesia0.50521854
133MP0001849_ear_inflammation0.49556929
134MP0000678_abnormal_parathyroid_gland0.49295929
135MP0002135_abnormal_kidney_morphology0.49216576
136MP0005666_abnormal_adipose_tissue0.48978318
137MP0006036_abnormal_mitochondrial_physio0.48061615
138MP0003186_abnormal_redox_activity0.45957883
139MP0000490_abnormal_crypts_of0.45804255
140MP0004947_skin_inflammation0.45093568
141* MP0002078_abnormal_glucose_homeostasis0.43344217
142MP0002971_abnormal_brown_adipose0.41447141
143MP0003953_abnormal_hormone_level0.38209634
144MP0009115_abnormal_fat_cell0.37427524
145MP0005395_other_phenotype0.37191424
146MP0002896_abnormal_bone_mineralization0.35675105
147MP0001191_abnormal_skin_condition0.35425000
148MP0003329_amyloid_beta_deposits0.35196867
149MP0005408_hypopigmentation0.32998460

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.15873647
2Hyperglycinuria (HP:0003108)5.23122152
3Abnormality of proline metabolism (HP:0010907)5.06579976
4Hydroxyprolinuria (HP:0003080)5.06579976
5Ileus (HP:0002595)4.99190022
6Hypobetalipoproteinemia (HP:0003563)4.91580638
7Malnutrition (HP:0004395)4.89504518
8Hyperactive renin-angiotensin system (HP:0000841)4.69676684
9Gout (HP:0001997)4.69047434
10Metabolic alkalosis (HP:0200114)4.65677072
11Abnormality of purine metabolism (HP:0004352)4.56587252
12Increased circulating renin level (HP:0000848)4.53458764
13Proximal tubulopathy (HP:0000114)4.40545504
14Abnormality of chloride homeostasis (HP:0011422)4.39146692
15Abnormal urine output (HP:0012590)4.33842587
16Acanthocytosis (HP:0001927)4.31191395
17Widely patent fontanelles and sutures (HP:0004492)4.26934471
18Glycosuria (HP:0003076)4.15191361
19Abnormality of urine glucose concentration (HP:0011016)4.15191361
20Hypokalemic alkalosis (HP:0001949)4.14388881
21Autoimmune thrombocytopenia (HP:0001973)4.14197219
22Abnormality of serine family amino acid metabolism (HP:0010894)4.12428468
23Abnormality of glycine metabolism (HP:0010895)4.12428468
24Abnormality of renal excretion (HP:0011036)4.12203247
25Congenital sensorineural hearing impairment (HP:0008527)3.95014950
26Macrocytic anemia (HP:0001972)3.94671652
27Hypomagnesemia (HP:0002917)3.83750749
28Hyperuricemia (HP:0002149)3.78484251
29Increased purine levels (HP:0004368)3.78484251
30Facial shape deformation (HP:0011334)3.75591402
31Potter facies (HP:0002009)3.75591402
32Abnormality of magnesium homeostasis (HP:0004921)3.74398574
33Conjugated hyperbilirubinemia (HP:0002908)3.69032957
34Abnormality of nucleobase metabolism (HP:0010932)3.58894724
35Polyuria (HP:0000103)3.55789785
36Xanthomatosis (HP:0000991)3.53719144
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.48367544
38Congenital, generalized hypertrichosis (HP:0004540)3.45228877
39Nephrolithiasis (HP:0000787)3.43871716
40Hyperphosphaturia (HP:0003109)3.41890080
41Fat malabsorption (HP:0002630)3.28064066
42Generalized aminoaciduria (HP:0002909)3.26029090
43Alkalosis (HP:0001948)3.23586840
44Ketoacidosis (HP:0001993)3.23276976
45Septo-optic dysplasia (HP:0100842)3.23215175
46Dehydration (HP:0001944)3.17327778
47Reticulocytopenia (HP:0001896)3.12332961
48Abnormal urine phosphate concentration (HP:0012599)3.08821646
49Metabolic acidosis (HP:0001942)3.01958312
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.94478089
51Abnormality of renin-angiotensin system (HP:0000847)2.93314985
52Limb dystonia (HP:0002451)2.92480196
53Hypolipoproteinemia (HP:0010981)2.92369894
54Hypercalciuria (HP:0002150)2.90327273
55Hyperaldosteronism (HP:0000859)2.89459363
56Hyperammonemia (HP:0001987)2.88963203
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.88057404
58Ketosis (HP:0001946)2.85776502
59Intrahepatic cholestasis (HP:0001406)2.81193299
60Renal Fanconi syndrome (HP:0001994)2.80545881
61Partial duplication of thumb phalanx (HP:0009944)2.79835363
62Confusion (HP:0001289)2.77908923
63Hypophosphatemia (HP:0002148)2.77094121
64Polydipsia (HP:0001959)2.76186301
65Abnormal drinking behavior (HP:0030082)2.76186301
66Increased hepatocellular lipid droplets (HP:0006565)2.75642325
67Partial duplication of the phalanx of hand (HP:0009999)2.72754396
68Pigmentary retinal degeneration (HP:0001146)2.69784904
69Abnormal number of erythroid precursors (HP:0012131)2.69730444
70Delayed epiphyseal ossification (HP:0002663)2.63263681
71Abnormality of fatty-acid metabolism (HP:0004359)2.63105990
72Abnormality of the vitamin B12 metabolism (HP:0004341)2.57572392
73Abnormality of cells of the erythroid lineage (HP:0012130)2.56766638
74Wide cranial sutures (HP:0010537)2.56745185
75Decreased circulating renin level (HP:0003351)2.56688351
76Tetany (HP:0001281)2.55637068
77Hyperventilation (HP:0002883)2.53750695
78Cupped ribs (HP:0000887)2.53426431
79Acute necrotizing encephalopathy (HP:0006965)2.51777524
80Renal tubular acidosis (HP:0001947)2.51269629
81Mitochondrial inheritance (HP:0001427)2.49903089
82Renal salt wasting (HP:0000127)2.48894952
83Renal tubular dysfunction (HP:0000124)2.45731549
84Lipid accumulation in hepatocytes (HP:0006561)2.44627085
85Ulnar claw (HP:0001178)2.43902050
86Poikilocytosis (HP:0004447)2.43600698
87Autoimmune hemolytic anemia (HP:0001890)2.43434453
88Acute encephalopathy (HP:0006846)2.40286535
89Abnormality of vitamin B metabolism (HP:0004340)2.40037177
90Vascular calcification (HP:0004934)2.37705801
91Hypothermia (HP:0002045)2.36529970
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33438399
93Rickets (HP:0002748)2.30417726
94Abnormal respiratory motile cilium morphology (HP:0005938)2.30389096
95Abnormal respiratory epithelium morphology (HP:0012253)2.30389096
96Abdominal distention (HP:0003270)2.30231512
97Abnormality of renal resorption (HP:0011038)2.28445127
98Hypokalemia (HP:0002900)2.27342500
99Nausea (HP:0002018)2.26697240
100Abnormal mitochondria in muscle tissue (HP:0008316)2.25634305
101Thin bony cortex (HP:0002753)2.22719900
102Abnormal tarsal ossification (HP:0008369)2.21723875
103Epidermoid cyst (HP:0200040)2.18954373
104Systemic lupus erythematosus (HP:0002725)2.18896602
105Sensorimotor neuropathy (HP:0007141)2.18843987
106Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18374221
107Lethargy (HP:0001254)2.17334123
108Focal segmental glomerulosclerosis (HP:0000097)2.16444850
109Delayed CNS myelination (HP:0002188)2.14240049
110Chronic diarrhea (HP:0002028)2.13206495
111Cardiovascular calcification (HP:0011915)2.11302506
112Abnormality of vitamin metabolism (HP:0100508)2.08219904
113Vomiting (HP:0002013)2.07636414
114Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05775145
115Dicarboxylic aciduria (HP:0003215)2.05775145
116Enlarged epiphyses (HP:0010580)2.04639813
117Hypercholesterolemia (HP:0003124)2.04297027
118True hermaphroditism (HP:0010459)2.04265612
119Cerebral edema (HP:0002181)2.01287565
120Hyperglycinemia (HP:0002154)2.00969232
121Right ventricular cardiomyopathy (HP:0011663)1.99473489
122Osteomalacia (HP:0002749)1.98311464
123Abnormal enzyme/coenzyme activity (HP:0012379)1.98242095
124Absent septum pellucidum (HP:0001331)1.98197157
125Megaloblastic anemia (HP:0001889)1.98018404
126Progressive macrocephaly (HP:0004481)1.97787341
127Exertional dyspnea (HP:0002875)1.92725515
128Metaphyseal cupping (HP:0003021)1.92402333
129Abnormality of alkaline phosphatase activity (HP:0004379)1.89530791
130Abnormality of potassium homeostasis (HP:0011042)1.88706369
131Hyperbilirubinemia (HP:0002904)1.88630995
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88007381
133Hypoglycemic coma (HP:0001325)1.87448457
134Chronic sinusitis (HP:0011109)1.86654216
135Pancreatitis (HP:0001733)1.86587075
136Late onset (HP:0003584)1.86498957
137Abnormal glucose tolerance (HP:0001952)1.85821777
138Hypoalbuminemia (HP:0003073)1.84405215
139Abnormal albumin level (HP:0012116)1.84405215
140Optic nerve hypoplasia (HP:0000609)1.83161358
141Esophageal atresia (HP:0002032)1.82037878
142Chorioretinal atrophy (HP:0000533)1.80920111
143Methylmalonic aciduria (HP:0012120)1.80804543
144Broad metatarsal (HP:0001783)1.80669012
145Polyphagia (HP:0002591)1.80544139
146Bone cyst (HP:0012062)1.75907837
147Maternal diabetes (HP:0009800)1.74869505
148Chronic otitis media (HP:0000389)1.74535055
149Rib fusion (HP:0000902)1.74036813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.30302061
2MST44.86948695
3ACVR1B4.86470529
4CASK4.79120340
5FRK4.58537135
6OXSR14.57801245
7TNIK4.54182483
8WNK34.15575960
9PNCK3.87626623
10MST1R3.77238412
11TLK13.33030061
12GRK63.24589359
13STK392.89781081
14LMTK22.71716113
15MARK12.48500324
16AKT32.43367371
17NME12.39325736
18PRKG22.23261830
19ERN12.13712850
20RIPK12.03421169
21EPHA22.03323836
22MAP3K102.02039916
23TSSK61.83260523
24BCKDK1.80377213
25ADRBK21.77839274
26PTK61.75057117
27MAP3K21.58542789
28VRK11.50933518
29EPHB11.50570542
30STK38L1.50146135
31DYRK21.46288112
32VRK21.40258817
33MET1.36485848
34NUAK11.29729638
35MAP2K21.28594949
36STK101.24230976
37MAP3K71.21485859
38NTRK21.18481272
39WEE11.16487996
40PDK31.16192785
41PDK41.16192785
42NLK1.16160616
43DYRK31.14412258
44PDK21.12171285
45MAPKAPK51.09584570
46PLK41.09544283
47MAP3K121.09086827
48MAPK131.08369635
49STK161.07598165
50TYRO31.05945972
51BMPR1B1.05165767
52FGFR41.03871633
53WNK11.02038416
54TAF11.01896785
55EPHB21.01695022
56EPHA41.01219094
57PRKCI0.97378696
58NEK10.96977507
59PTK20.95376578
60DMPK0.93981455
61PIK3CA0.92614495
62TAOK10.91496780
63LATS10.90548969
64PRKAA20.89150944
65TIE10.88934866
66PRKCG0.87071214
67LRRK20.85008136
68BMX0.84638722
69ADRBK10.79852953
70EPHA30.79172681
71MAP3K30.76653285
72SGK2230.76042605
73SGK4940.76042605
74ZAK0.76008616
75TESK20.75928779
76MAPK110.75874220
77FER0.75383216
78FGFR20.74181537
79PDPK10.71763599
80CAMK2B0.71555708
81DDR20.70501932
82CAMK2A0.69956944
83PRKG10.68820278
84MAP3K110.68130365
85STK240.67867859
86DYRK1B0.67739179
87PAK40.64946667
88SIK20.64401405
89INSRR0.62671588
90TAOK30.61211587
91ERBB40.61178158
92PRKACA0.60998363
93PRKAA10.60428705
94SGK30.58940321
95IRAK30.58391137
96GSK3A0.58300835
97MATK0.57680163
98MAP3K80.56232385
99MAP2K60.55590769
100ERBB20.54685889
101TBK10.53824580
102NTRK30.53078680
103TESK10.52960800
104TGFBR10.52564969
105MYLK0.51774263
106STK380.49451669
107PRKCE0.49051811
108MKNK20.47751465
109RIPK40.46801587
110IRAK10.46105506
111PAK30.43330856
112GRK70.43161773
113CDK30.43134753
114PDK10.42984618
115ICK0.41752675
116CAMK2D0.40443750
117NEK20.39994236
118MAP3K10.39852342
119CAMK2G0.39558006
120MINK10.38526958
121MAP2K40.37451647
122UHMK10.37295891
123KSR20.37233870
124TTK0.36784169
125SCYL20.35480190
126MAP2K70.33908547
127MELK0.33666592
128PRKCZ0.33204587
129STK110.32882058
130CHUK0.31496941
131MAP4K10.30168680
132BRSK20.29886432
133PRKACG0.29780215
134PHKG10.29698063
135PHKG20.29698063
136TYK20.29383927
137PRKCA0.28676098
138CSK0.28351189
139MAPK40.27505619
140RPS6KA50.27435173
141PRKCD0.26794733
142MAP2K10.26235562
143RPS6KA60.25927305
144AKT20.25383205
145PRKCQ0.25270014
146PBK0.23780559
147SGK20.21907083
148STK30.21075829
149JAK20.19113008
150SRC0.18298720
151MAPK150.16388398
152ABL20.15554155
153SGK10.13926373
154CSNK1A10.13482070
155ROCK10.13189892
156MAP3K140.13145270
157GRK10.11438936
158ITK0.10759725
159PINK10.09494624
160FYN0.08894132

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.01288185
2Vitamin digestion and absorption_Homo sapiens_hsa049773.76391787
3Renin-angiotensin system_Homo sapiens_hsa046143.40351959
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.98758144
5Mineral absorption_Homo sapiens_hsa049782.96261731
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83882611
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80232037
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.73659637
9Ribosome_Homo sapiens_hsa030102.66308215
10Caffeine metabolism_Homo sapiens_hsa002322.40704613
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.24124502
12Parkinsons disease_Homo sapiens_hsa050122.20656907
13Folate biosynthesis_Homo sapiens_hsa007902.19348648
14Linoleic acid metabolism_Homo sapiens_hsa005912.17803429
15Galactose metabolism_Homo sapiens_hsa000522.15832743
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15263590
17Bile secretion_Homo sapiens_hsa049762.13023225
18Sulfur metabolism_Homo sapiens_hsa009202.08318046
19Butanoate metabolism_Homo sapiens_hsa006502.04675718
20Tryptophan metabolism_Homo sapiens_hsa003802.04513748
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01311563
22* Starch and sucrose metabolism_Homo sapiens_hsa005002.00294030
23Protein digestion and absorption_Homo sapiens_hsa049741.96387332
24Fatty acid degradation_Homo sapiens_hsa000711.84902798
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84722579
26Arginine biosynthesis_Homo sapiens_hsa002201.70851666
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70599361
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65944108
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64453080
30Histidine metabolism_Homo sapiens_hsa003401.63882586
31Peroxisome_Homo sapiens_hsa041461.62444605
32PPAR signaling pathway_Homo sapiens_hsa033201.61832445
33Huntingtons disease_Homo sapiens_hsa050161.59990258
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.59856254
35Glutathione metabolism_Homo sapiens_hsa004801.58664508
36Cardiac muscle contraction_Homo sapiens_hsa042601.57783628
37Pyruvate metabolism_Homo sapiens_hsa006201.57653783
38Alzheimers disease_Homo sapiens_hsa050101.55979937
39Fructose and mannose metabolism_Homo sapiens_hsa000511.52796893
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49947535
41Propanoate metabolism_Homo sapiens_hsa006401.43239642
42Cocaine addiction_Homo sapiens_hsa050301.40914673
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39429191
44Nitrogen metabolism_Homo sapiens_hsa009101.36188644
45beta-Alanine metabolism_Homo sapiens_hsa004101.33696590
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32635149
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28761686
48Arginine and proline metabolism_Homo sapiens_hsa003301.28436097
49Glycerolipid metabolism_Homo sapiens_hsa005611.25198316
50Carbon metabolism_Homo sapiens_hsa012001.18715287
51Fatty acid metabolism_Homo sapiens_hsa012121.15976813
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15818210
53Nicotine addiction_Homo sapiens_hsa050331.12154127
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.07660802
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05821603
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03745630
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.02191175
58Ether lipid metabolism_Homo sapiens_hsa005651.01298475
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01235677
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93480637
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91793275
62Sphingolipid metabolism_Homo sapiens_hsa006000.91210534
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89228006
64Chemical carcinogenesis_Homo sapiens_hsa052040.87590078
65ABC transporters_Homo sapiens_hsa020100.84662774
66Selenocompound metabolism_Homo sapiens_hsa004500.82236471
67Retinol metabolism_Homo sapiens_hsa008300.80408038
68Lysine degradation_Homo sapiens_hsa003100.80262317
69Biosynthesis of amino acids_Homo sapiens_hsa012300.77286649
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75399771
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.75219666
72Amphetamine addiction_Homo sapiens_hsa050310.71387331
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69959065
74Serotonergic synapse_Homo sapiens_hsa047260.67405933
75Pentose phosphate pathway_Homo sapiens_hsa000300.63567037
76Taste transduction_Homo sapiens_hsa047420.62874373
77Phenylalanine metabolism_Homo sapiens_hsa003600.59988139
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55625414
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55273612
80Asthma_Homo sapiens_hsa053100.51738805
81Insulin secretion_Homo sapiens_hsa049110.51451719
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49695566
83Collecting duct acid secretion_Homo sapiens_hsa049660.49430635
84Thyroid hormone synthesis_Homo sapiens_hsa049180.46269634
85Basal cell carcinoma_Homo sapiens_hsa052170.42706267
86* Metabolic pathways_Homo sapiens_hsa011000.42244895
87RNA polymerase_Homo sapiens_hsa030200.41317644
88Fatty acid elongation_Homo sapiens_hsa000620.38233304
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37697243
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37637237
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37574644
92Steroid biosynthesis_Homo sapiens_hsa001000.37496845
93Other glycan degradation_Homo sapiens_hsa005110.36848347
94Glutamatergic synapse_Homo sapiens_hsa047240.36141987
95Protein export_Homo sapiens_hsa030600.34924633
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.34109519
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31140336
98Dopaminergic synapse_Homo sapiens_hsa047280.30488475
99Cholinergic synapse_Homo sapiens_hsa047250.29844326
100Hedgehog signaling pathway_Homo sapiens_hsa043400.29271448
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.27792721
102Arachidonic acid metabolism_Homo sapiens_hsa005900.26800857
103African trypanosomiasis_Homo sapiens_hsa051430.26744437
104Phototransduction_Homo sapiens_hsa047440.23329227
105Ovarian steroidogenesis_Homo sapiens_hsa049130.23311737
106Gap junction_Homo sapiens_hsa045400.23066496
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22369663
108Gastric acid secretion_Homo sapiens_hsa049710.21938602
109Tyrosine metabolism_Homo sapiens_hsa003500.20383568
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20291736
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20047245
112Tight junction_Homo sapiens_hsa045300.18962819
113Morphine addiction_Homo sapiens_hsa050320.17953187
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.14332420
115Insulin resistance_Homo sapiens_hsa049310.12770977
116Circadian entrainment_Homo sapiens_hsa047130.11065805
117GABAergic synapse_Homo sapiens_hsa047270.10382157
118Type II diabetes mellitus_Homo sapiens_hsa049300.09887860
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08739356
120Bladder cancer_Homo sapiens_hsa052190.04764736
121Pancreatic secretion_Homo sapiens_hsa049720.04635459
122Sulfur relay system_Homo sapiens_hsa041220.03438640
123Fatty acid biosynthesis_Homo sapiens_hsa000610.03435675
124Hepatitis C_Homo sapiens_hsa051600.03100852
125Choline metabolism in cancer_Homo sapiens_hsa052310.01826797
126Vibrio cholerae infection_Homo sapiens_hsa051100.00340514
127Renin secretion_Homo sapiens_hsa04924-0.0972881
128Oxidative phosphorylation_Homo sapiens_hsa00190-0.0934262
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0924818
130AMPK signaling pathway_Homo sapiens_hsa04152-0.0770191
131Complement and coagulation cascades_Homo sapiens_hsa04610-0.0721961
132Lysosome_Homo sapiens_hsa04142-0.0667652
133Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0565917
134Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0215842
135Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0149731
136Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0042262

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