TREM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.89587712
2neutrophil activation involved in immune response (GO:0002283)6.58065158
3modulation by symbiont of host immune response (GO:0052553)6.52222328
4positive regulation by symbiont of host defense response (GO:0052509)6.52222328
5modulation by symbiont of host defense response (GO:0052031)6.52222328
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.52222328
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.52222328
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.52222328
9leukocyte aggregation (GO:0070486)6.47792154
10negative regulation of cell killing (GO:0031342)5.50555379
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.50555379
12respiratory burst (GO:0045730)5.39563416
13production of molecular mediator involved in inflammatory response (GO:0002532)5.19091458
14positive regulation of mast cell activation (GO:0033005)4.87071587
15granulocyte activation (GO:0036230)4.82356890
16positive regulation of mast cell degranulation (GO:0043306)4.81922217
17positive regulation of mast cell activation involved in immune response (GO:0033008)4.81922217
18neutrophil activation (GO:0042119)4.78731552
19response to host immune response (GO:0052572)4.74086203
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.74086203
21macrophage activation involved in immune response (GO:0002281)4.59974258
22regulation of mast cell degranulation (GO:0043304)4.57792858
23positive regulation of chemokine biosynthetic process (GO:0045080)4.50187611
24response to host (GO:0075136)4.34392042
25response to host defenses (GO:0052200)4.34392042
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.34392042
27immunoglobulin mediated immune response (GO:0016064)4.30516477
28antigen processing and presentation of endogenous antigen (GO:0019883)4.29301743
29negative regulation of interleukin-12 production (GO:0032695)4.26860366
30regulation of mast cell activation involved in immune response (GO:0033006)4.26716778
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26092429
32regulation of mast cell activation (GO:0033003)4.18935274
33superoxide anion generation (GO:0042554)4.18306205
34detection of other organism (GO:0098543)4.16479604
35lipopolysaccharide-mediated signaling pathway (GO:0031663)4.16018786
36hydrogen peroxide biosynthetic process (GO:0050665)4.10294756
37regulation of gamma-delta T cell activation (GO:0046643)4.09126680
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.02168201
39response to muramyl dipeptide (GO:0032495)4.00042327
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.97099258
41reactive oxygen species biosynthetic process (GO:1903409)3.95786935
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.93293018
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90090891
44positive regulation of cellular amide metabolic process (GO:0034250)3.86967195
45positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.85853955
46detection of bacterium (GO:0016045)3.84385939
47regulation of leukocyte degranulation (GO:0043300)3.83828718
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.83359807
49regulation of chemokine biosynthetic process (GO:0045073)3.81924626
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77744469
51* neutrophil mediated immunity (GO:0002446)3.75554480
52negative regulation of mast cell activation (GO:0033004)3.75230575
53myeloid cell activation involved in immune response (GO:0002275)3.74197514
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.74178041
55regulation of B cell receptor signaling pathway (GO:0050855)3.70099176
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.68961393
57regulation of interferon-beta biosynthetic process (GO:0045357)3.67338456
58leukocyte migration involved in inflammatory response (GO:0002523)3.63994246
59response to fungus (GO:0009620)3.63177611
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.61231014
61positive regulation of heat generation (GO:0031652)3.60664705
62microglial cell activation (GO:0001774)3.60616655
63positive regulation of leukocyte degranulation (GO:0043302)3.59144105
64detection of molecule of bacterial origin (GO:0032490)3.58001653
65positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.56151963
66* neutrophil chemotaxis (GO:0030593)3.55847773
67regulation of fever generation (GO:0031620)3.55354008
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54531358
69germinal center formation (GO:0002467)3.53264635
70regulation of T-helper 2 cell differentiation (GO:0045628)3.50328198
71positive regulation of interferon-alpha production (GO:0032727)3.48530915
72* neutrophil migration (GO:1990266)3.45237639
73negative regulation of growth of symbiont in host (GO:0044130)3.44636076
74negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.44636076
75modulation of growth of symbiont involved in interaction with host (GO:0044144)3.44636076
76regulation of growth of symbiont in host (GO:0044126)3.44636076
77leukocyte cell-cell adhesion (GO:0007159)3.44156036
78negative regulation of leukocyte mediated immunity (GO:0002704)3.43317122
79negative regulation of T cell mediated immunity (GO:0002710)3.41376959
80regulation of interferon-alpha production (GO:0032647)3.40548451
81detection of external biotic stimulus (GO:0098581)3.40141803
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39580911
83defense response to protozoan (GO:0042832)3.38543377
84leukotriene metabolic process (GO:0006691)3.32988539
85regulation of gamma-delta T cell differentiation (GO:0045586)3.32697742
86macrophage activation (GO:0042116)3.31879033
87cellular response to zinc ion (GO:0071294)3.31610524
88positive regulation of antigen processing and presentation (GO:0002579)3.28503906
89T-helper 1 type immune response (GO:0042088)3.28091937
90B cell mediated immunity (GO:0019724)3.27088939
91positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.26207702
92response to interleukin-15 (GO:0070672)3.25290379
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22279418
94positive regulation of toll-like receptor signaling pathway (GO:0034123)3.18915533
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.17700132
96regulation of tolerance induction (GO:0002643)3.17139270
97regulation of regulated secretory pathway (GO:1903305)3.16944630
98defense response to fungus (GO:0050832)3.16441341
99negative regulation of interleukin-1 production (GO:0032692)3.15717892
100negative regulation of erythrocyte differentiation (GO:0045647)3.15666470
101negative regulation of interleukin-6 production (GO:0032715)3.13993678
102detection of biotic stimulus (GO:0009595)3.13155733
103positive regulation of gamma-delta T cell activation (GO:0046645)3.11474245
104* cellular extravasation (GO:0045123)3.10688228
105* granulocyte chemotaxis (GO:0071621)3.10133520
106regulation of macrophage cytokine production (GO:0010935)3.08123962
107Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07348562
108chronic inflammatory response (GO:0002544)3.03893342
109phagosome maturation (GO:0090382)3.03264020
110response to protozoan (GO:0001562)3.03083551
111* granulocyte migration (GO:0097530)3.02327070
112antigen processing and presentation via MHC class Ib (GO:0002475)3.01329412
113negative regulation of interleukin-1 beta production (GO:0032691)3.00668525
114regulation of vitamin D biosynthetic process (GO:0060556)2.98924333
115leukocyte degranulation (GO:0043299)2.98639274
116regulation of T-helper 1 cell differentiation (GO:0045625)2.97912723
117* myeloid leukocyte mediated immunity (GO:0002444)2.97231413
118positive regulation of NF-kappaB import into nucleus (GO:0042346)2.96467307
119sequestering of metal ion (GO:0051238)2.95914240
120regulation of T cell tolerance induction (GO:0002664)2.93550256
121regulation of B cell differentiation (GO:0045577)2.93343710
122regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93104743
123negative regulation of myeloid cell apoptotic process (GO:0033033)2.92689638
124regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92333905
125regulation of interleukin-8 biosynthetic process (GO:0045414)2.91879475
126negative regulation of T-helper cell differentiation (GO:0045623)2.91862112
127negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91862112
128negative regulation of interleukin-17 production (GO:0032700)2.91692555
129cellular response to type I interferon (GO:0071357)2.91345737
130type I interferon signaling pathway (GO:0060337)2.91345737
131myeloid leukocyte activation (GO:0002274)2.90506904
132cellular response to interleukin-15 (GO:0071350)2.90421131
133negative regulation of toll-like receptor signaling pathway (GO:0034122)2.89936591
134positive regulation of interferon-beta production (GO:0032728)2.89579191
135interferon-gamma-mediated signaling pathway (GO:0060333)2.89469358
136response to type I interferon (GO:0034340)2.88634443
137dendritic cell migration (GO:0036336)2.88496609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.20804091
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.65721627
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.81675933
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.28611677
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.22927868
6MYB_21317192_ChIP-Seq_ERMYB_Mouse4.09461483
7EGR1_19374776_ChIP-ChIP_THP-1_Human4.00290131
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.97267518
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.77602769
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61644990
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.53611077
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20365454
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84994357
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.80595353
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.74346237
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72507848
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.70029548
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.68720165
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57477686
20SPI1_23547873_ChIP-Seq_NB4_Human2.55148169
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52445421
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40137986
23SCL_19346495_ChIP-Seq_HPC-7_Human2.27369591
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27177781
25VDR_24763502_ChIP-Seq_THP-1_Human2.20587571
26SPI1_23127762_ChIP-Seq_K562_Human1.95588471
27* RUNX1_22412390_ChIP-Seq_EML_Mouse1.94208246
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92961348
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90111860
30PU_27001747_Chip-Seq_BMDM_Mouse1.87821778
31RUNX_20019798_ChIP-Seq_JUKART_Human1.87510807
32MYB_26560356_Chip-Seq_TH2_Human1.87012147
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84139244
34VDR_24787735_ChIP-Seq_THP-1_Human1.83244631
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.82388617
36CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81385653
37VDR_21846776_ChIP-Seq_THP-1_Human1.75321782
38* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71574962
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70737019
40MAF_26560356_Chip-Seq_TH1_Human1.67415657
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66790565
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65830808
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62350140
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57001227
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53924427
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52389832
47CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50713520
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47621447
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46067016
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44570157
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43674962
52MYB_26560356_Chip-Seq_TH1_Human1.39012792
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.37940298
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34300554
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33307828
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29257274
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28979923
58UTX_26944678_Chip-Seq_JUKART_Human1.28461304
59GATA3_27048872_Chip-Seq_THYMUS_Human1.28405143
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24551952
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23992242
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23864669
63GATA3_26560356_Chip-Seq_TH2_Human1.23510491
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21458269
65E2F7_22180533_ChIP-Seq_HELA_Human1.18961637
66* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17494723
67TCF7_22412390_ChIP-Seq_EML_Mouse1.09727584
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.03384646
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02847541
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02097803
71* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02001815
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.00989013
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00338765
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99574383
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98796191
76GATA2_19941826_ChIP-Seq_K562_Human0.92609460
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91957644
78MYC_22102868_ChIP-Seq_BL_Human0.89769762
79LXR_22292898_ChIP-Seq_THP-1_Human0.87620436
80SPI1_20517297_ChIP-Seq_HL60_Human0.87542813
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85375669
82GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84800378
83EGR1_19032775_ChIP-ChIP_M12_Human0.83832920
84MAF_26560356_Chip-Seq_TH2_Human0.83678386
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83079473
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82947329
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82543613
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82266532
89NCOR1_26117541_ChIP-Seq_K562_Human0.82229299
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.81420187
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.80670636
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80287421
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80034102
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78969749
95* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76586663
96BCL6_27268052_Chip-Seq_Bcells_Human0.75839156
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75472215
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75356928
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74496226
100GATA1_22025678_ChIP-Seq_K562_Human0.74465886
101BCOR_27268052_Chip-Seq_Bcells_Human0.72554559
102GATA1_19941826_ChIP-Seq_K562_Human0.71378437
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.70565463
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68821918
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66958560
106TFEB_21752829_ChIP-Seq_HELA_Human0.66448903
107* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.63740604
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61737430
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61033295
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61033295
111KDM2B_26808549_Chip-Seq_DND41_Human0.60836918
112SMRT_27268052_Chip-Seq_Bcells_Human0.60737177
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59734853
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.57168385
115KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.56939378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.75453314
2MP0003303_peritoneal_inflammation4.25293292
3MP0009785_altered_susceptibility_to4.19249888
4MP0001835_abnormal_antigen_presentation3.83393230
5MP0002419_abnormal_innate_immunity3.68858262
6MP0002148_abnormal_hypersensitivity_rea3.53131686
7MP0003724_increased_susceptibility_to3.45401615
8MP0005000_abnormal_immune_tolerance3.18034764
9MP0005025_abnormal_response_to3.08052704
10MP0009278_abnormal_bone_marrow2.98343388
11MP0002452_abnormal_antigen_presenting2.60204180
12MP0001790_abnormal_immune_system2.57664067
13MP0005387_immune_system_phenotype2.57664067
14MP0001533_abnormal_skeleton_physiology2.50478814
15MP0004510_myositis2.49512044
16MP0002723_abnormal_immune_serum2.42954735
17MP0000343_altered_response_to2.40603122
18MP0001800_abnormal_humoral_immune2.38191347
19MP0001819_abnormal_immune_cell2.30661889
20MP0002420_abnormal_adaptive_immunity2.29935720
21MP0009764_decreased_sensitivity_to2.27243699
22MP0000685_abnormal_immune_system2.22968988
23MP0006082_CNS_inflammation2.21424167
24MP0005464_abnormal_platelet_physiology2.14011643
25MP0002405_respiratory_system_inflammati2.08886317
26MP0001853_heart_inflammation2.07549254
27MP0005671_abnormal_response_to2.01550822
28MP0003075_altered_response_to2.01499182
29MP0001845_abnormal_inflammatory_respons2.00899969
30MP0005397_hematopoietic_system_phenotyp1.94988739
31MP0001545_abnormal_hematopoietic_system1.94988739
32MP0004947_skin_inflammation1.87004996
33MP0005058_abnormal_lysosome_morphology1.84433540
34MP0005167_abnormal_blood-brain_barrier1.82817330
35MP0003448_altered_tumor_morphology1.78400324
36MP0000858_altered_metastatic_potential1.68333095
37MP0003183_abnormal_peptide_metabolism1.67624136
38MP0008004_abnormal_stomach_pH1.65613607
39MP0008469_abnormal_protein_level1.63154726
40MP0003828_pulmonary_edema1.61432734
41MP0000716_abnormal_immune_system1.59531459
42MP0010155_abnormal_intestine_physiology1.58521894
43MP0002398_abnormal_bone_marrow1.51014696
44MP0005076_abnormal_cell_differentiation1.49522495
45MP0003172_abnormal_lysosome_physiology1.49169695
46MP0002277_abnormal_respiratory_mucosa1.47981154
47MP0005166_decreased_susceptibility_to1.43746510
48MP0003191_abnormal_cellular_cholesterol1.40551295
49MP0003300_gastrointestinal_ulcer1.38608230
50MP0009333_abnormal_splenocyte_physiolog1.35735137
51MP0005310_abnormal_salivary_gland1.33853381
52MP0005164_abnormal_response_to1.33015162
53MP0002006_tumorigenesis1.30766976
54MP0002138_abnormal_hepatobiliary_system1.29158390
55MP0002429_abnormal_blood_cell1.28663802
56MP0002933_joint_inflammation1.28209818
57MP0008260_abnormal_autophagy1.27136217
58MP0000689_abnormal_spleen_morphology1.26894928
59MP0002998_abnormal_bone_remodeling1.24542171
60MP0000465_gastrointestinal_hemorrhage1.24438888
61MP0005390_skeleton_phenotype1.23213346
62MP0003866_abnormal_defecation1.21534579
63MP0002722_abnormal_immune_system1.18810219
64MP0001851_eye_inflammation1.12939234
65MP0004381_abnormal_hair_follicle1.12432144
66MP0003566_abnormal_cell_adhesion1.07535337
67MP0004808_abnormal_hematopoietic_stem1.07167866
68MP0003453_abnormal_keratinocyte_physiol0.99006960
69MP0001873_stomach_inflammation0.98781206
70MP0005174_abnormal_tail_pigmentation0.98685929
71MP0003186_abnormal_redox_activity0.97387598
72MP0004883_abnormal_blood_vessel0.96388892
73MP0003656_abnormal_erythrocyte_physiolo0.96161484
74MP0004782_abnormal_surfactant_physiolog0.93802223
75MP0009840_abnormal_foam_cell0.92112892
76MP0000604_amyloidosis0.90857717
77MP0002396_abnormal_hematopoietic_system0.89764730
78MP0009763_increased_sensitivity_to0.88084139
79MP0010307_abnormal_tumor_latency0.87955290
80MP0003045_fibrosis0.86479832
81MP0001663_abnormal_digestive_system0.84322859
82MP0002332_abnormal_exercise_endurance0.82446957
83MP0000569_abnormal_digit_pigmentation0.81647303
84MP0003221_abnormal_cardiomyocyte_apopto0.78291132
85MP0000249_abnormal_blood_vessel0.75581455
86MP0005451_abnormal_body_composition0.74874464
87MP0003690_abnormal_glial_cell0.74071741
88MP0010352_gastrointestinal_tract_polyps0.73202668
89MP0003279_aneurysm0.72747901
90MP0000490_abnormal_crypts_of0.72042079
91MP0002009_preneoplasia0.70237424
92MP0005023_abnormal_wound_healing0.70133140
93MP0003795_abnormal_bone_structure0.69431512
94MP0004484_altered_response_of0.69345101
95MP0002133_abnormal_respiratory_system0.65444074
96MP0005388_respiratory_system_phenotype0.65444074
97MP0002254_reproductive_system_inflammat0.65045228
98MP0002166_altered_tumor_susceptibility0.62053811
99MP0008874_decreased_physiological_sensi0.61150009
100MP0003763_abnormal_thymus_physiology0.60712865
101MP0003806_abnormal_nucleotide_metabolis0.60162302
102MP0006054_spinal_hemorrhage0.57216949
103MP0002132_abnormal_respiratory_system0.56726676
104MP0000015_abnormal_ear_pigmentation0.54944929
105MP0000371_diluted_coat_color0.54145041
106MP0000703_abnormal_thymus_morphology0.53420559
107MP0001958_emphysema0.52611686
108MP0008873_increased_physiological_sensi0.52480623
109MP0001191_abnormal_skin_condition0.52473530
110MP0000920_abnormal_myelination0.50525813
111MP0002019_abnormal_tumor_incidence0.50334819
112MP0004130_abnormal_muscle_cell0.50319236
113MP0005376_homeostasis/metabolism_phenot0.49326890
114MP0003091_abnormal_cell_migration0.47480960
115MP0000767_abnormal_smooth_muscle0.46976032
116MP0009765_abnormal_xenobiotic_induced0.46500389

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.58648606
2Eczematoid dermatitis (HP:0000976)7.92314801
3Recurrent bacterial skin infections (HP:0005406)7.59594850
4Recurrent gram-negative bacterial infections (HP:0005420)7.09527866
5Abnormality of macrophages (HP:0004311)5.88600351
6Stomatitis (HP:0010280)5.81243937
7Mediastinal lymphadenopathy (HP:0100721)5.78370605
8Myositis (HP:0100614)5.34861859
9Chronic obstructive pulmonary disease (HP:0006510)5.13387067
10Obstructive lung disease (HP:0006536)5.13387067
11Orchitis (HP:0100796)5.12466204
12Retrobulbar optic neuritis (HP:0100654)4.88644907
13Optic neuritis (HP:0100653)4.88644907
14Gingivitis (HP:0000230)4.63905247
15Elevated erythrocyte sedimentation rate (HP:0003565)4.58597957
16Recurrent skin infections (HP:0001581)4.47587297
17Recurrent fungal infections (HP:0002841)4.12511054
18Urticaria (HP:0001025)3.96659615
19Autoimmune thrombocytopenia (HP:0001973)3.86109962
20Vacuolated lymphocytes (HP:0001922)3.71756703
21Cellulitis (HP:0100658)3.53034699
22Spontaneous hematomas (HP:0007420)3.51821608
23Vasculitis (HP:0002633)3.50857960
24Meningitis (HP:0001287)3.47341172
25Keratoconjunctivitis sicca (HP:0001097)3.13096240
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.09050086
27Interstitial pulmonary disease (HP:0006530)3.08194658
28Increased cerebral lipofuscin (HP:0011813)3.08154152
29Systemic lupus erythematosus (HP:0002725)3.00202059
30Periodontitis (HP:0000704)2.96763877
31Pulmonary infiltrates (HP:0002113)2.96110025
32Pustule (HP:0200039)2.94467966
33Hemoptysis (HP:0002105)2.81435387
34Keratoconjunctivitis (HP:0001096)2.81416792
35Recurrent cutaneous fungal infections (HP:0011370)2.80798406
36Chronic mucocutaneous candidiasis (HP:0002728)2.80798406
37Arterial thrombosis (HP:0004420)2.80640808
38Recurrent viral infections (HP:0004429)2.76783866
39Recurrent pneumonia (HP:0006532)2.75045844
40Hypochromic microcytic anemia (HP:0004840)2.73240859
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.69693601
42T lymphocytopenia (HP:0005403)2.67558426
43Osteomyelitis (HP:0002754)2.66320775
44Abnormality of T cell number (HP:0011839)2.61453023
45Leukocytosis (HP:0001974)2.57915557
46Basal ganglia calcification (HP:0002135)2.51147649
47Prostate neoplasm (HP:0100787)2.50976136
48Hypochromic anemia (HP:0001931)2.50571825
49Disinhibition (HP:0000734)2.50457378
50Hematochezia (HP:0002573)2.48140668
51Gingival bleeding (HP:0000225)2.46238174
52Dysostosis multiplex (HP:0000943)2.45412445
53Petechiae (HP:0000967)2.45337801
54Axonal loss (HP:0003447)2.42955182
55Abnormality of the peritoneum (HP:0002585)2.41858995
56Agnosia (HP:0010524)2.38061593
57Increased IgM level (HP:0003496)2.37967271
58Poor head control (HP:0002421)2.37866403
59Joint hemorrhage (HP:0005261)2.36299535
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32786430
61Recurrent lower respiratory tract infections (HP:0002783)2.30747939
62Gastrointestinal infarctions (HP:0005244)2.29245417
63Neoplasm of head and neck (HP:0012288)2.27333347
64Esophageal neoplasm (HP:0100751)2.27333347
65Chest pain (HP:0100749)2.26654753
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.26286170
67Amyloidosis (HP:0011034)2.26220563
68Vertigo (HP:0002321)2.24801953
69Granulocytopenia (HP:0001913)2.24768650
70Abnormality of T cells (HP:0002843)2.23031912
71Sepsis (HP:0100806)2.22903601
72Thick nail (HP:0001805)2.20645855
73Chronic otitis media (HP:0000389)2.20237369
74Epistaxis (HP:0000421)2.19866893
75Loss of speech (HP:0002371)2.19334185
76Tetraparesis (HP:0002273)2.18502316
77Pulmonary embolism (HP:0002204)2.17600018
78Abnormality of the pleura (HP:0002103)2.17367946
79Increased serum ferritin (HP:0003281)2.16969054
80Skin ulcer (HP:0200042)2.12347158
81Keratitis (HP:0000491)2.11760187
82Anorexia (HP:0002039)2.11453287
83Acne (HP:0001061)2.10629942
84Polyneuropathy (HP:0001271)2.09252173
85Encephalitis (HP:0002383)2.09188758
86IgM deficiency (HP:0002850)2.08384557
87Purpura (HP:0000979)2.05323178
88Segmental peripheral demyelination/remyelination (HP:0003481)2.04307549
89Peritonitis (HP:0002586)2.03692385
90Premature loss of primary teeth (HP:0006323)2.00615518
91Mucopolysacchariduria (HP:0008155)1.99592724
92Urinary glycosaminoglycan excretion (HP:0003541)1.99592724
93Slow saccadic eye movements (HP:0000514)1.99320730
94Hepatosplenomegaly (HP:0001433)1.96931023
95Abnormality of iron homeostasis (HP:0011031)1.95614370
96Inflammation of the large intestine (HP:0002037)1.94469070
97Gangrene (HP:0100758)1.93909508
98Cheilitis (HP:0100825)1.93898271
99Abnormality of liposaccharide metabolism (HP:0010968)1.93770193
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.93770193
101Abnormality of glycolipid metabolism (HP:0010969)1.93770193
102Subacute progressive viral hepatitis (HP:0006572)1.93549401
103Myocardial infarction (HP:0001658)1.92731094
104Hypergammaglobulinemia (HP:0010702)1.92693511
105Abnormality of T cell physiology (HP:0011840)1.92512974
106Microcytic anemia (HP:0001935)1.90961162
107Abnormality of the prostate (HP:0008775)1.89854013
108Restrictive lung disease (HP:0002091)1.89057880
109Abnormality of the pericardium (HP:0001697)1.88826645
110Colitis (HP:0002583)1.88509346
111Prolonged bleeding time (HP:0003010)1.87161655
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87137325
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86816634
114Abnormality of polysaccharide metabolism (HP:0011012)1.86816634
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86816634
116Arthralgia (HP:0002829)1.86215615
117Increased IgE level (HP:0003212)1.85703261
118Thrombophlebitis (HP:0004418)1.85613417
119Glomerulonephritis (HP:0000099)1.85569584
120Eosinophilia (HP:0001880)1.85104025
121Viral hepatitis (HP:0006562)1.84383839
122Abnormal platelet volume (HP:0011876)1.81111465
123Skin rash (HP:0000988)1.79225038
124Gastrointestinal inflammation (HP:0004386)1.79200890
125Lymphopenia (HP:0001888)1.78947789
126Amaurosis fugax (HP:0100576)1.78622217
127Glomerulopathy (HP:0100820)1.78134669
128Episodic fever (HP:0001954)1.77483483
129Abnormality of the endocardium (HP:0004306)1.76258630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.47952632
2RIPK44.25750442
3IRAK44.23637524
4MAP3K143.84479931
5IRAK33.13474496
6MAP4K13.12200267
7STK103.01933759
8TBK12.91622361
9CSK2.44050989
10ERN12.38097699
11FGR2.29358886
12EPHB12.15741094
13TYK22.12451131
14IKBKB2.02260732
15BTK1.86487506
16TEC1.85273453
17IKBKE1.82077613
18TXK1.81795970
19FES1.77721508
20IRAK11.74620018
21CLK11.69312793
22IRAK21.68804167
23JAK31.66504578
24KIT1.59108730
25KSR21.56324104
26ZAP701.49912165
27HCK1.44884375
28MAP3K121.37541182
29TGFBR21.33260450
30SYK1.29637313
31RPS6KA41.28110907
32PIM21.24849463
33CHUK1.24204435
34TAOK31.20094396
35MARK31.17014483
36LRRK21.16904241
37LYN1.16753269
38RIPK11.14089344
39PIM11.14051527
40CSF1R1.10494762
41MST41.09556470
42TRPM71.09464293
43PBK1.09122510
44MAP3K21.06778595
45JAK11.02980942
46PRPF4B1.02186243
47ITK0.98324399
48MAP2K30.95233717
49MARK20.94365930
50GRK60.94268344
51MATK0.92805388
52EIF2AK20.92062440
53MAP3K60.90630240
54JAK20.90319530
55MAP3K100.89984526
56PIK3CG0.88730053
57STK240.85824700
58LCK0.84298748
59PDPK10.81193045
60YES10.81073843
61MAP3K130.80938429
62ABL20.80127689
63EPHA30.79317853
64MAP3K110.78369920
65GRK70.77127762
66PRKCD0.76892755
67MAP3K50.74973713
68PRKD20.73314096
69MAPK70.73094089
70FLT30.71886246
71PAK40.71358476
72PRKG20.68698608
73MAPK120.66556376
74PTK60.64947627
75MAPKAPK20.63755366
76SGK30.63676975
77KSR10.63559959
78ABL10.62531470
79RAF10.62150785
80MAP2K40.61093782
81RPS6KA60.59818322
82DAPK20.58136782
83ERBB30.56969516
84MAP3K30.56744191
85CDK190.56634210
86CDC42BPA0.56360329
87MAPK40.55604033
88EGFR0.54850343
89MAP3K70.52582826
90BMPR20.51457616
91WNK10.51427457
92BMX0.50887674
93SGK20.50759437
94RPS6KL10.50681770
95RPS6KC10.50681770
96STK40.49558454
97STK110.49179151
98PRKCQ0.48735202
99SIK30.47785153
100ALK0.46834258
101MAP3K10.46000164
102HIPK20.44530704
103DYRK1B0.44372477
104MAP3K80.43930916
105FYN0.42906725
106RPS6KA20.41626973
107MOS0.41148527
108RET0.39962752
109STK30.39702731
110NLK0.39277909
111TRIB30.38352383
112TAOK20.37110399
113STK380.36586090
114RPS6KA10.35595667
115DYRK30.34218801
116MST1R0.33413283
117MAP2K60.33009838
118TESK20.32701758
119FGFR40.32618508
120PTK20.29257969
121CAMK40.28941326
122KDR0.28927681
123SIK20.28224862
124PTK2B0.27317446
125PDK10.25397904
126TTN0.24376580
127FGFR30.22772924
128EIF2AK30.22570251
129PKN20.21299207
130TNK20.21117495
131TAOK10.17981510
132NUAK10.15702352

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051404.01582019
2Staphylococcus aureus infection_Homo sapiens_hsa051503.38949287
3Graft-versus-host disease_Homo sapiens_hsa053322.98506296
4Legionellosis_Homo sapiens_hsa051342.98465570
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.75312506
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67217909
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.66150284
8Osteoclast differentiation_Homo sapiens_hsa043802.56096375
9Tuberculosis_Homo sapiens_hsa051522.52518114
10Malaria_Homo sapiens_hsa051442.49588835
11Pertussis_Homo sapiens_hsa051332.33754945
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19189729
13Rheumatoid arthritis_Homo sapiens_hsa053232.18894943
14TNF signaling pathway_Homo sapiens_hsa046682.02352404
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01216529
16Salmonella infection_Homo sapiens_hsa051321.98451862
17Asthma_Homo sapiens_hsa053101.93198179
18Phagosome_Homo sapiens_hsa041451.87517386
19Allograft rejection_Homo sapiens_hsa053301.86158348
20Type I diabetes mellitus_Homo sapiens_hsa049401.86053086
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82625026
22Measles_Homo sapiens_hsa051621.82506959
23Hematopoietic cell lineage_Homo sapiens_hsa046401.82001276
24African trypanosomiasis_Homo sapiens_hsa051431.80672380
25B cell receptor signaling pathway_Homo sapiens_hsa046621.67301627
26Shigellosis_Homo sapiens_hsa051311.57367607
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56758383
28Chemokine signaling pathway_Homo sapiens_hsa040621.56484580
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54342204
30Lysosome_Homo sapiens_hsa041421.51978307
31Influenza A_Homo sapiens_hsa051641.50445125
32Toxoplasmosis_Homo sapiens_hsa051451.49848262
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47471136
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.39864723
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.34322516
36Herpes simplex infection_Homo sapiens_hsa051681.34236432
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32563945
38Other glycan degradation_Homo sapiens_hsa005111.26207950
39Apoptosis_Homo sapiens_hsa042101.25003917
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.23000607
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.17605567
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13489694
43Hepatitis B_Homo sapiens_hsa051611.12034997
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11786502
45Amoebiasis_Homo sapiens_hsa051461.10274818
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04038846
47Antigen processing and presentation_Homo sapiens_hsa046120.99637753
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98924809
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97582949
50Renal cell carcinoma_Homo sapiens_hsa052110.90041421
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.84954318
52Viral myocarditis_Homo sapiens_hsa054160.82778575
53Acute myeloid leukemia_Homo sapiens_hsa052210.79852268
54Hepatitis C_Homo sapiens_hsa051600.77568028
55Autoimmune thyroid disease_Homo sapiens_hsa053200.74729808
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.68762894
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68111118
58T cell receptor signaling pathway_Homo sapiens_hsa046600.66584461
59GnRH signaling pathway_Homo sapiens_hsa049120.65350521
60Pancreatic cancer_Homo sapiens_hsa052120.64236762
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64188979
62Epstein-Barr virus infection_Homo sapiens_hsa051690.63756244
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62471958
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62345536
65Chronic myeloid leukemia_Homo sapiens_hsa052200.62335888
66Endometrial cancer_Homo sapiens_hsa052130.61576859
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61040801
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60981305
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60976234
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60629877
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58558561
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58156557
73Choline metabolism in cancer_Homo sapiens_hsa052310.58128477
74Platelet activation_Homo sapiens_hsa046110.57622725
75Complement and coagulation cascades_Homo sapiens_hsa046100.57430521
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56320039
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55556124
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.54103285
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49420067
80Bladder cancer_Homo sapiens_hsa052190.48307388
81Primary immunodeficiency_Homo sapiens_hsa053400.46379497
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.45994557
83mTOR signaling pathway_Homo sapiens_hsa041500.45540322
84Colorectal cancer_Homo sapiens_hsa052100.44372298
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44252572
86ErbB signaling pathway_Homo sapiens_hsa040120.44189120
87Regulation of autophagy_Homo sapiens_hsa041400.43916901
88Pentose phosphate pathway_Homo sapiens_hsa000300.42753816
89Inositol phosphate metabolism_Homo sapiens_hsa005620.41364315
90VEGF signaling pathway_Homo sapiens_hsa043700.39942960
91Viral carcinogenesis_Homo sapiens_hsa052030.39646605
92Rap1 signaling pathway_Homo sapiens_hsa040150.39173709
93Estrogen signaling pathway_Homo sapiens_hsa049150.38488000
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36811582
95HIF-1 signaling pathway_Homo sapiens_hsa040660.36208562
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34896224
97Collecting duct acid secretion_Homo sapiens_hsa049660.34796026
98Prion diseases_Homo sapiens_hsa050200.34581829
99MAPK signaling pathway_Homo sapiens_hsa040100.32058554
100FoxO signaling pathway_Homo sapiens_hsa040680.31697386
101Prolactin signaling pathway_Homo sapiens_hsa049170.31565748
102Endocytosis_Homo sapiens_hsa041440.30994264
103Mineral absorption_Homo sapiens_hsa049780.29236151
104Insulin resistance_Homo sapiens_hsa049310.28171225
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27009392
106Small cell lung cancer_Homo sapiens_hsa052220.26774623
107p53 signaling pathway_Homo sapiens_hsa041150.26258054
108Dorso-ventral axis formation_Homo sapiens_hsa043200.24040523
109Proteoglycans in cancer_Homo sapiens_hsa052050.23077449
110HTLV-I infection_Homo sapiens_hsa051660.22293680
111Sphingolipid metabolism_Homo sapiens_hsa006000.20542505
112MicroRNAs in cancer_Homo sapiens_hsa052060.19095859
113Type II diabetes mellitus_Homo sapiens_hsa049300.18030580
114Renin-angiotensin system_Homo sapiens_hsa046140.15634459
115Notch signaling pathway_Homo sapiens_hsa043300.14912727
116Non-small cell lung cancer_Homo sapiens_hsa052230.14628561
117Caffeine metabolism_Homo sapiens_hsa002320.11143708
118Vibrio cholerae infection_Homo sapiens_hsa051100.09552988
119Starch and sucrose metabolism_Homo sapiens_hsa005000.06937832

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