TREML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.43363389
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.12463007
3negative regulation of cell killing (GO:0031342)6.12463007
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.11694968
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.11694968
6modulation by symbiont of host immune response (GO:0052553)6.11694968
7positive regulation by symbiont of host defense response (GO:0052509)6.11694968
8modulation by symbiont of host defense response (GO:0052031)6.11694968
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.11694968
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07933920
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.07933920
12antigen processing and presentation of endogenous antigen (GO:0019883)5.58815856
13neutrophil activation involved in immune response (GO:0002283)5.32875372
14positive regulation of gamma-delta T cell activation (GO:0046645)5.12586830
15detection of other organism (GO:0098543)5.11045189
16macrophage activation involved in immune response (GO:0002281)4.99702856
17definitive hemopoiesis (GO:0060216)4.95047400
18viral transcription (GO:0019083)4.85797755
19detection of bacterium (GO:0016045)4.82233387
20cellular extravasation (GO:0045123)4.80064684
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.66196613
22translational termination (GO:0006415)4.63230211
23response to peptidoglycan (GO:0032494)4.62043759
24regulation of interferon-beta biosynthetic process (GO:0045357)4.52801702
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51386879
26leukocyte migration involved in inflammatory response (GO:0002523)4.50518933
27detection of molecule of bacterial origin (GO:0032490)4.48343976
28detection of external biotic stimulus (GO:0098581)4.44078266
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.36987019
30neutrophil activation (GO:0042119)4.36157822
31response to host immune response (GO:0052572)4.35403522
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.35403522
33negative regulation of lymphocyte mediated immunity (GO:0002707)4.30192930
34positive regulation of B cell differentiation (GO:0045579)4.19766874
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.14418110
36negative regulation of interleukin-12 production (GO:0032695)4.05778482
37respiratory burst (GO:0045730)4.04293959
38antigen processing and presentation via MHC class Ib (GO:0002475)4.03393433
39translational elongation (GO:0006414)4.02644629
40microglial cell activation (GO:0001774)4.00146520
41megakaryocyte development (GO:0035855)3.99160110
42response to host (GO:0075136)3.96920680
43response to host defenses (GO:0052200)3.96920680
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.96920680
45regulation of gamma-delta T cell differentiation (GO:0045586)3.96702768
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96675918
47negative regulation of phagocytosis (GO:0050765)3.96129522
48ribosomal small subunit biogenesis (GO:0042274)3.95944304
49production of molecular mediator involved in inflammatory response (GO:0002532)3.93539063
50granulocyte activation (GO:0036230)3.93296584
51cotranslational protein targeting to membrane (GO:0006613)3.86116702
52detection of biotic stimulus (GO:0009595)3.85977601
53protein targeting to ER (GO:0045047)3.85542560
54regulation of mast cell degranulation (GO:0043304)3.81517766
55neutrophil mediated immunity (GO:0002446)3.77207646
56negative regulation of leukocyte mediated immunity (GO:0002704)3.74433888
57myeloid cell activation involved in immune response (GO:0002275)3.73788179
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73549537
59B cell receptor signaling pathway (GO:0050853)3.72615688
60response to interferon-beta (GO:0035456)3.72196496
61negative regulation of erythrocyte differentiation (GO:0045647)3.70599839
62macrophage activation (GO:0042116)3.69250209
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68214363
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.64370336
65negative regulation of T-helper cell differentiation (GO:0045623)3.64370336
66protein localization to endoplasmic reticulum (GO:0070972)3.62896729
67regulation of gamma-delta T cell activation (GO:0046643)3.62333529
68regulation of B cell differentiation (GO:0045577)3.58955504
69negative regulation of T cell mediated immunity (GO:0002710)3.57317162
70viral life cycle (GO:0019058)3.56701915
71T cell homeostasis (GO:0043029)3.53869728
72regulation of mast cell activation involved in immune response (GO:0033006)3.53506284
73regulation of T-helper 2 cell differentiation (GO:0045628)3.52816477
74positive regulation of mast cell activation (GO:0033005)3.51070522
75cellular protein complex disassembly (GO:0043624)3.50191583
76regulation of B cell receptor signaling pathway (GO:0050855)3.49083795
77germinal center formation (GO:0002467)3.45617354
78maturation of SSU-rRNA (GO:0030490)3.43617142
79regulation of myeloid leukocyte mediated immunity (GO:0002886)3.40849345
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.38293052
81Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37155505
82regulation of mast cell activation (GO:0033003)3.35411490
83cellular response to zinc ion (GO:0071294)3.29505003
84response to type I interferon (GO:0034340)3.29229935
85mast cell activation (GO:0045576)3.28920313
86response to protozoan (GO:0001562)3.28611883
87leukocyte degranulation (GO:0043299)3.28129236
88regulation of leukocyte degranulation (GO:0043300)3.24922511
89cellular response to type I interferon (GO:0071357)3.24648416
90type I interferon signaling pathway (GO:0060337)3.24648416
91translational initiation (GO:0006413)3.24249596
92defense response to protozoan (GO:0042832)3.24244139
93mature B cell differentiation involved in immune response (GO:0002313)3.24241650
94protein complex disassembly (GO:0043241)3.21011980
95myeloid leukocyte mediated immunity (GO:0002444)3.19346367
96mature B cell differentiation (GO:0002335)3.19057057
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18542675
98lymph node development (GO:0048535)3.18183009
99response to muramyl dipeptide (GO:0032495)3.17288669
100leukocyte aggregation (GO:0070486)3.15823960
101positive regulation of granulocyte differentiation (GO:0030854)3.12519547
102regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.09562546
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06970202
104positive regulation of interferon-alpha production (GO:0032727)3.03814155
105response to interferon-alpha (GO:0035455)3.02909227
106positive regulation of mast cell activation involved in immune response (GO:0033008)3.02574549
107positive regulation of mast cell degranulation (GO:0043306)3.02574549
108myeloid dendritic cell activation (GO:0001773)3.00395763
109negative regulation of alpha-beta T cell activation (GO:0046636)3.00282424
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00110129
111negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99939183
112regulation of T cell tolerance induction (GO:0002664)2.98998408
113dendritic cell migration (GO:0036336)2.98305731
114lymphocyte homeostasis (GO:0002260)2.97822361
115tolerance induction (GO:0002507)2.97004463
116regulation of tolerance induction (GO:0002643)2.96109877
117macromolecular complex disassembly (GO:0032984)2.95232366
118regulation of erythrocyte differentiation (GO:0045646)2.95213218
119negative regulation of type 2 immune response (GO:0002829)2.94973719
120negative regulation of interleukin-6 production (GO:0032715)2.94806513
121DNA deamination (GO:0045006)2.94690401
122dendritic cell chemotaxis (GO:0002407)2.93573703
123interferon-gamma production (GO:0032609)2.93380926
124immunoglobulin mediated immune response (GO:0016064)2.93319013
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.92870563
126mast cell activation involved in immune response (GO:0002279)2.92797357
127mast cell degranulation (GO:0043303)2.92797357
128regulation of T cell mediated cytotoxicity (GO:0001914)2.89590816
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89585953
130positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89515374
131response to interleukin-15 (GO:0070672)2.89491889
132regulation of interleukin-12 biosynthetic process (GO:0045075)2.88380804
133leukocyte homeostasis (GO:0001776)2.88275222
134regulation of alpha-beta T cell proliferation (GO:0046640)2.87290636
135CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.85860194
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85366585
137regulation of regulated secretory pathway (GO:1903305)2.84830728
138embryonic hemopoiesis (GO:0035162)2.83466126
139regulation of T cell receptor signaling pathway (GO:0050856)2.82699541
140mRNA catabolic process (GO:0006402)2.81634621
141negative T cell selection (GO:0043383)2.78987681
142Peyers patch development (GO:0048541)2.78428553
143mucosal-associated lymphoid tissue development (GO:0048537)2.78428553
144negative thymic T cell selection (GO:0045060)2.77926944
145telomere maintenance via semi-conservative replication (GO:0032201)2.77071082
146cellular response to interferon-beta (GO:0035458)2.72793970
147interferon-gamma-mediated signaling pathway (GO:0060333)2.72662594
148T cell migration (GO:0072678)2.70544407
149RNA catabolic process (GO:0006401)2.67423719
150platelet dense granule organization (GO:0060155)2.65777482
151myeloid dendritic cell differentiation (GO:0043011)2.64249189
152regulation of type I interferon-mediated signaling pathway (GO:0060338)2.61057436
153lymphoid progenitor cell differentiation (GO:0002320)2.60876273
154regulation of regulatory T cell differentiation (GO:0045589)2.59944673
155antigen receptor-mediated signaling pathway (GO:0050851)2.58006381
156secretory granule organization (GO:0033363)2.56593946
157B cell mediated immunity (GO:0019724)2.55908660
158DNA strand elongation involved in DNA replication (GO:0006271)2.55260938
159NIK/NF-kappaB signaling (GO:0038061)2.52766337
160DNA unwinding involved in DNA replication (GO:0006268)2.52372417
161granulocyte differentiation (GO:0030851)2.51678958
162B cell homeostasis (GO:0001782)2.51118921
163DNA strand elongation (GO:0022616)2.50851264
164regulation of necroptotic process (GO:0060544)2.50583915
165positive thymic T cell selection (GO:0045059)2.49914876
166cellular response to interleukin-15 (GO:0071350)2.49890138
167hepatocyte apoptotic process (GO:0097284)2.49275396
168protein targeting to membrane (GO:0006612)2.48705449
169necroptotic process (GO:0070266)2.47462815
170ribosomal large subunit biogenesis (GO:0042273)2.47129602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.78350788
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.11502527
3SCL_19346495_ChIP-Seq_HPC-7_Human3.64133557
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48976074
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40681571
6MYC_22102868_ChIP-Seq_BL_Human3.27988412
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14705757
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98840341
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.93994079
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.85580642
11VDR_21846776_ChIP-Seq_THP-1_Human2.78551305
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77099741
13* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67815141
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.62138809
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54631152
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.51907965
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51354024
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.45082095
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.44645714
20* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33043831
21* SPI1_23547873_ChIP-Seq_NB4_Human2.31670145
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31499655
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24373180
24MYB_26560356_Chip-Seq_TH2_Human2.23745568
25* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23338791
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21148812
27MAF_26560356_Chip-Seq_TH1_Human2.11902217
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.10710202
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10566771
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09729577
31VDR_24763502_ChIP-Seq_THP-1_Human2.02278158
32MYB_26560356_Chip-Seq_TH1_Human2.01530658
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.99113905
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97293591
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94499253
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92172750
37* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92033978
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90822314
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.90534937
40UTX_26944678_Chip-Seq_JUKART_Human1.90358715
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.87969756
42CIITA_25753668_ChIP-Seq_RAJI_Human1.86566792
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85095330
44TCF7_22412390_ChIP-Seq_EML_Mouse1.84137005
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83521743
46* IRF8_27001747_Chip-Seq_BMDM_Mouse1.79951314
47VDR_24787735_ChIP-Seq_THP-1_Human1.79244154
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78974319
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78725636
50RUNX_20019798_ChIP-Seq_JUKART_Human1.77799768
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73002027
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67947740
53VDR_23849224_ChIP-Seq_CD4+_Human1.67002304
54GATA1_19941826_ChIP-Seq_K562_Human1.65821913
55FOXP3_21729870_ChIP-Seq_TREG_Human1.64636019
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62730916
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61405950
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.61254659
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60061761
60* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.59429247
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.56356807
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.55030046
63* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52598947
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51056003
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49950804
66GATA1_22025678_ChIP-Seq_K562_Human1.49169035
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49162885
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45086974
69MAF_26560356_Chip-Seq_TH2_Human1.43758583
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43547940
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41944085
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41904446
73* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41805250
74XRN2_22483619_ChIP-Seq_HELA_Human1.39818087
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38909689
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38468258
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36677962
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.35598364
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35224578
80SPI1_23127762_ChIP-Seq_K562_Human1.34798236
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33011011
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32484329
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32413943
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31970673
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28289842
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.27631507
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26219663
88GATA2_19941826_ChIP-Seq_K562_Human1.25003032
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.22589721
90* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21388203
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19775746
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19167094
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19159291
94GATA3_27048872_Chip-Seq_THYMUS_Human1.18973923
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18803228
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.16881503
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.16804837
98ELK1_19687146_ChIP-ChIP_HELA_Human1.15074939
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14674115
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14079677
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13684325
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13025852
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12462073
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11964103
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11283062
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10036250
107* PU_27001747_Chip-Seq_BMDM_Mouse1.08612752
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08172533
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.07621121
110BCL6_27268052_Chip-Seq_Bcells_Human1.05273318
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04446305
112LXR_22292898_ChIP-Seq_THP-1_Human1.03552486
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99792435
114BCOR_27268052_Chip-Seq_Bcells_Human0.99760030
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99732839
116KDM2B_26808549_Chip-Seq_DND41_Human0.97658215
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96832305
118RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96695033
119SRF_21415370_ChIP-Seq_HL-1_Mouse0.95974206
120* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94580766
121ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94536506
122TTF2_22483619_ChIP-Seq_HELA_Human0.93902777
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.93866561
124GABP_19822575_ChIP-Seq_HepG2_Human0.93745857
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91928051
126MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91551401
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90875550
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90799649
129DCP1A_22483619_ChIP-Seq_HELA_Human0.90123205
130NCOR1_26117541_ChIP-Seq_K562_Human0.90100590
131GATA3_26560356_Chip-Seq_TH2_Human0.90085569
132SPI1_20517297_ChIP-Seq_HL60_Human0.87908837
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87133699
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86641455
135TFEB_21752829_ChIP-Seq_HELA_Human0.85300912
136SMRT_27268052_Chip-Seq_Bcells_Human0.81257801
137GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79996474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.05895673
2MP0002396_abnormal_hematopoietic_system3.61569862
3MP0000685_abnormal_immune_system3.15017860
4MP0004808_abnormal_hematopoietic_stem3.14869536
5MP0005671_abnormal_response_to3.12854567
6MP0001800_abnormal_humoral_immune2.97267615
7MP0003763_abnormal_thymus_physiology2.95705108
8MP0009785_altered_susceptibility_to2.94991387
9MP0002398_abnormal_bone_marrow2.73655069
10MP0002452_abnormal_antigen_presenting2.61647502
11MP0005387_immune_system_phenotype2.59988293
12MP0001790_abnormal_immune_system2.59988293
13MP0003436_decreased_susceptibility_to2.59764792
14MP0002420_abnormal_adaptive_immunity2.55248029
15MP0005000_abnormal_immune_tolerance2.51318645
16MP0001819_abnormal_immune_cell2.51318144
17MP0001545_abnormal_hematopoietic_system2.49982152
18MP0005397_hematopoietic_system_phenotyp2.49982152
19MP0005025_abnormal_response_to2.49959694
20MP0002723_abnormal_immune_serum2.49862501
21MP0005464_abnormal_platelet_physiology2.40311860
22MP0000716_abnormal_immune_system2.30977827
23MP0005174_abnormal_tail_pigmentation2.30552995
24MP0000689_abnormal_spleen_morphology2.29249468
25MP0002166_altered_tumor_susceptibility2.24432605
26MP0002722_abnormal_immune_system2.22288616
27MP0000465_gastrointestinal_hemorrhage2.19018565
28MP0002419_abnormal_innate_immunity2.15741962
29MP0002148_abnormal_hypersensitivity_rea2.14976503
30MP0008260_abnormal_autophagy2.12435271
31MP0002429_abnormal_blood_cell2.06170058
32MP0009333_abnormal_splenocyte_physiolog2.02703909
33MP0003303_peritoneal_inflammation1.99805148
34MP0000490_abnormal_crypts_of1.96827453
35MP0010155_abnormal_intestine_physiology1.95926047
36MP0000703_abnormal_thymus_morphology1.89954235
37MP0001853_heart_inflammation1.89603383
38MP0002405_respiratory_system_inflammati1.88755693
39MP0003724_increased_susceptibility_to1.88277255
40MP0001873_stomach_inflammation1.84815483
41MP0009278_abnormal_bone_marrow1.84288291
42MP0003866_abnormal_defecation1.83843147
43MP0008057_abnormal_DNA_replication1.74154323
44MP0002006_tumorigenesis1.73808862
45MP0005075_abnormal_melanosome_morpholog1.73359967
46MP0005451_abnormal_body_composition1.68661785
47MP0010094_abnormal_chromosome_stability1.68161451
48MP0003693_abnormal_embryo_hatching1.60667622
49MP0001845_abnormal_inflammatory_respons1.58439843
50MP0003300_gastrointestinal_ulcer1.55237459
51MP0002095_abnormal_skin_pigmentation1.47919351
52MP0002277_abnormal_respiratory_mucosa1.46383016
53MP0003077_abnormal_cell_cycle1.45315299
54MP0008058_abnormal_DNA_repair1.32831149
55MP0002019_abnormal_tumor_incidence1.31711671
56MP0004947_skin_inflammation1.28786640
57MP0004883_abnormal_blood_vessel1.23490304
58MP0003656_abnormal_erythrocyte_physiolo1.20024064
59MP0008007_abnormal_cellular_replicative1.19825420
60MP0003111_abnormal_nucleus_morphology1.19362829
61MP0001986_abnormal_taste_sensitivity1.17013513
62MP0008469_abnormal_protein_level1.14522847
63MP0003075_altered_response_to1.13161064
64MP0005310_abnormal_salivary_gland1.11726402
65MP0000858_altered_metastatic_potential1.10778220
66MP0000015_abnormal_ear_pigmentation1.10036842
67MP0008004_abnormal_stomach_pH1.09160693
68MP0006082_CNS_inflammation1.06021913
69MP0004510_myositis1.03911569
70MP0002998_abnormal_bone_remodeling1.03748413
71MP0001533_abnormal_skeleton_physiology1.02969105
72MP0004957_abnormal_blastocyst_morpholog1.01862102
73MP0002138_abnormal_hepatobiliary_system1.00202988
74MP0002132_abnormal_respiratory_system1.00072089
75MP0005164_abnormal_response_to0.99505167
76MP0006054_spinal_hemorrhage0.99408275
77MP0003943_abnormal_hepatobiliary_system0.98884358
78MP0004147_increased_porphyrin_level0.97753347
79MP0010307_abnormal_tumor_latency0.93968484
80MP0000313_abnormal_cell_death0.93732581
81MP0003045_fibrosis0.92636193
82MP0010352_gastrointestinal_tract_polyps0.92544304
83MP0002933_joint_inflammation0.90884954
84MP0005166_decreased_susceptibility_to0.89791736
85MP0005377_hearing/vestibular/ear_phenot0.89134494
86MP0003878_abnormal_ear_physiology0.89134494
87MP0005083_abnormal_biliary_tract0.83317746
88MP0003448_altered_tumor_morphology0.82075134
89MP0002877_abnormal_melanocyte_morpholog0.79257213
90MP0005390_skeleton_phenotype0.77608810
91MP0001851_eye_inflammation0.77270624
92MP0001663_abnormal_digestive_system0.76504823
93MP0003183_abnormal_peptide_metabolism0.75739168
94MP0009379_abnormal_foot_pigmentation0.74844465
95MP0009764_decreased_sensitivity_to0.72457240
96MP0003690_abnormal_glial_cell0.71929606
97MP0005409_darkened_coat_color0.70258820
98MP0000343_altered_response_to0.68919276
99MP0003221_abnormal_cardiomyocyte_apopto0.66668207
100MP0008874_decreased_physiological_sensi0.65349291
101MP0003828_pulmonary_edema0.64761930
102MP0000477_abnormal_intestine_morphology0.63349191
103MP0009763_increased_sensitivity_to0.63290365
104MP0000350_abnormal_cell_proliferation0.63260610
105MP0003172_abnormal_lysosome_physiology0.62184767
106MP0001348_abnormal_lacrimal_gland0.59220753
107MP0009765_abnormal_xenobiotic_induced0.58845736
108MP0003786_premature_aging0.58806965
109MP0004130_abnormal_muscle_cell0.56586777
110MP0002928_abnormal_bile_duct0.54444631
111MP0003191_abnormal_cellular_cholesterol0.53331638
112MP0000598_abnormal_liver_morphology0.51977857
113MP0008873_increased_physiological_sensi0.51495739
114MP0002075_abnormal_coat/hair_pigmentati0.50503758
115MP0005319_abnormal_enzyme/_coenzyme0.49707062
116MP0004484_altered_response_of0.48439808
117MP0000604_amyloidosis0.47546235
118MP0002332_abnormal_exercise_endurance0.46286955
119MP0002693_abnormal_pancreas_physiology0.45945279
120MP0000569_abnormal_digit_pigmentation0.44994646
121MP0000609_abnormal_liver_physiology0.44659692
122MP0009931_abnormal_skin_appearance0.44496615
123MP0000371_diluted_coat_color0.43665572
124MP0004381_abnormal_hair_follicle0.42731311
125MP0005076_abnormal_cell_differentiation0.42572997
126MP0002009_preneoplasia0.42082159
127MP0000249_abnormal_blood_vessel0.41671126
128MP0003795_abnormal_bone_structure0.41108538

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.28117974
2Chronic otitis media (HP:0000389)4.95531698
3IgM deficiency (HP:0002850)4.83419418
4Hypochromic microcytic anemia (HP:0004840)4.73864123
5Recurrent gram-negative bacterial infections (HP:0005420)4.70122259
6Gastrointestinal infarctions (HP:0005244)4.48483442
7Recurrent bronchitis (HP:0002837)4.27374055
8Recurrent viral infections (HP:0004429)4.22417476
9Prolonged bleeding time (HP:0003010)4.21533218
10Petechiae (HP:0000967)4.20534916
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.08231855
12Elevated erythrocyte sedimentation rate (HP:0003565)4.04976048
13Abnormality of cells of the erythroid lineage (HP:0012130)3.98832963
14Cellulitis (HP:0100658)3.92346834
15Recurrent fungal infections (HP:0002841)3.91126544
16Abnormal number of erythroid precursors (HP:0012131)3.90124320
17Agammaglobulinemia (HP:0004432)3.87280212
18Recurrent abscess formation (HP:0002722)3.83364277
19Keratoconjunctivitis sicca (HP:0001097)3.83172989
20Panhypogammaglobulinemia (HP:0003139)3.72602323
21Myositis (HP:0100614)3.68195548
22Reticulocytopenia (HP:0001896)3.62855559
23Urticaria (HP:0001025)3.57852012
24Recurrent bacterial skin infections (HP:0005406)3.57607354
25Aplastic anemia (HP:0001915)3.56680591
26Keratoconjunctivitis (HP:0001096)3.55317330
27Meningitis (HP:0001287)3.54871345
28Gingivitis (HP:0000230)3.48268342
29Eczematoid dermatitis (HP:0000976)3.47014834
30Abnormality of T cell physiology (HP:0011840)3.44454753
31Abnormality of T cells (HP:0002843)3.35484170
32Chronic mucocutaneous candidiasis (HP:0002728)3.25487706
33Recurrent cutaneous fungal infections (HP:0011370)3.25487706
34Episodic fever (HP:0001954)3.23513240
35Epistaxis (HP:0000421)3.22021404
36Gastrointestinal inflammation (HP:0004386)3.18537708
37Nasal polyposis (HP:0100582)3.16161397
38Lymphopenia (HP:0001888)3.10145204
39Inflammation of the large intestine (HP:0002037)3.08699356
40Spontaneous hematomas (HP:0007420)3.08594095
41Abnormality of the nasal mucosa (HP:0000433)3.06047858
42IgG deficiency (HP:0004315)3.02044328
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.99977290
44Abnormality of the fingertips (HP:0001211)2.99622557
45Recurrent skin infections (HP:0001581)2.97962722
46T lymphocytopenia (HP:0005403)2.96762616
47Pulmonary infiltrates (HP:0002113)2.94467308
48Chronic sinusitis (HP:0011109)2.92397385
49Anorexia (HP:0002039)2.86530535
50Poikiloderma (HP:0001029)2.85243741
51B lymphocytopenia (HP:0010976)2.84585966
52Abnormality of B cell number (HP:0010975)2.84585966
53Abnormal platelet function (HP:0011869)2.84516008
54Impaired platelet aggregation (HP:0003540)2.84516008
55Gastrointestinal stroma tumor (HP:0100723)2.84213932
56Vasculitis (HP:0002633)2.82064049
57Mediastinal lymphadenopathy (HP:0100721)2.81352513
58Peritonitis (HP:0002586)2.79289228
59Abnormality of T cell number (HP:0011839)2.79146745
60Obstructive lung disease (HP:0006536)2.73809455
61Chronic obstructive pulmonary disease (HP:0006510)2.73809455
62Pulmonary embolism (HP:0002204)2.70641581
63Pallor (HP:0000980)2.69442656
64Lymphoma (HP:0002665)2.68841208
65Increased IgM level (HP:0003496)2.66912083
66Thyroiditis (HP:0100646)2.66689571
67Gingival bleeding (HP:0000225)2.62480274
68Myelodysplasia (HP:0002863)2.60707178
69Acute myeloid leukemia (HP:0004808)2.58915215
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58600769
71Papilloma (HP:0012740)2.57347491
72Verrucae (HP:0200043)2.57347491
73Sepsis (HP:0100806)2.53514594
74Chest pain (HP:0100749)2.52278769
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.51981756
76Recurrent sinusitis (HP:0011108)2.50605375
77Colitis (HP:0002583)2.47053849
78Abnormal platelet volume (HP:0011876)2.46654939
79Increased IgE level (HP:0003212)2.44633696
80Encephalitis (HP:0002383)2.43114083
81Amaurosis fugax (HP:0100576)2.41407064
82Abnormality of the peritoneum (HP:0002585)2.41263135
83Gangrene (HP:0100758)2.37380184
84Bronchitis (HP:0012387)2.35912109
85Abnormality of the prostate (HP:0008775)2.35317269
86Abnormality of the pleura (HP:0002103)2.34620952
87IgA deficiency (HP:0002720)2.34046649
88Osteomyelitis (HP:0002754)2.33537516
89Purpura (HP:0000979)2.32605821
90Interstitial pulmonary disease (HP:0006530)2.31650417
91Pustule (HP:0200039)2.31458546
92Granulocytopenia (HP:0001913)2.29937622
93Leukocytosis (HP:0001974)2.28028077
94Microcytic anemia (HP:0001935)2.24839267
95Autoimmune thrombocytopenia (HP:0001973)2.24384870
96Macrocytic anemia (HP:0001972)2.23808852
97Abnormality of macrophages (HP:0004311)2.23435631
98Entropion (HP:0000621)2.21657062
99Neutropenia (HP:0001875)2.20375337
100Amyloidosis (HP:0011034)2.20313734
101Skin ulcer (HP:0200042)2.16684454
102Abnormality of eosinophils (HP:0001879)2.15849324
103Hypergammaglobulinemia (HP:0010702)2.15687183
104Polycythemia (HP:0001901)2.15077457
105Viral hepatitis (HP:0006562)2.14770152
106Arterial thrombosis (HP:0004420)2.14530814
107Eosinophilia (HP:0001880)2.13194603
108Orchitis (HP:0100796)2.13087449
109Glomerulopathy (HP:0100820)2.12167970
110Acute lymphatic leukemia (HP:0006721)2.12003849
111Hypochromic anemia (HP:0001931)2.11890857
112Cutaneous melanoma (HP:0012056)2.11254934
113Basal cell carcinoma (HP:0002671)2.10404291
114Slow saccadic eye movements (HP:0000514)2.09672545
115Recurrent lower respiratory tract infections (HP:0002783)2.08249021
116Keratitis (HP:0000491)2.07214416
117Severe combined immunodeficiency (HP:0004430)2.04449415
118Chronic diarrhea (HP:0002028)2.04209607
119Periodontitis (HP:0000704)2.04170192
120Abnormality of the endocardium (HP:0004306)2.03301017
121Retrobulbar optic neuritis (HP:0100654)2.02373798
122Optic neuritis (HP:0100653)2.02373798
123Abnormality of DNA repair (HP:0003254)2.02309696
124Stomatitis (HP:0010280)2.01101126
125Recurrent pneumonia (HP:0006532)2.00715316
126Skin rash (HP:0000988)1.99977386
127Vertigo (HP:0002321)1.99626430
128Hemoptysis (HP:0002105)1.99625512
129Toxemia of pregnancy (HP:0100603)1.98866406
130Acute hepatic failure (HP:0006554)1.98495435
131Hypoplasia of the thymus (HP:0000778)1.98022061
132Acne (HP:0001061)1.97622659
133Abnormality of the pericardium (HP:0001697)1.92397720
134Hepatosplenomegaly (HP:0001433)1.91710735
135Premature loss of primary teeth (HP:0006323)1.91649844
136Abnormality of iron homeostasis (HP:0011031)1.91145206
137Autoimmune hemolytic anemia (HP:0001890)1.91135684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.71994999
2EEF2K3.65927268
3BTK2.59104390
4KIT2.48475222
5PRPF4B2.31867494
6JAK32.25456551
7TEC2.25021501
8TXK2.15122710
9NME22.06785022
10IRAK42.05696730
11ZAP701.91348879
12GRK61.90123853
13SYK1.86830006
14BLK1.82931872
15TAOK11.81520319
16TGFBR11.80282181
17TYK21.77963848
18TBK11.70153701
19IKBKE1.69973181
20MAP3K31.69477776
21MAP3K101.65611971
22CSF1R1.59330127
23MAP3K111.59063537
24FGR1.54975970
25PKN21.52902365
26FLT31.51870149
27STK101.51544902
28LRRK21.50106465
29RPS6KB21.47826005
30PIM11.43764152
31FES1.39780056
32KSR21.39252355
33PIM21.38553082
34TGFBR21.37625459
35TAOK31.35206460
36MAP3K11.32893257
37RIPK41.32833745
38IKBKB1.28857901
39MAP2K31.28483636
40STK161.24522116
41LCK1.20143625
42TNK21.17954525
43MAP3K131.16449380
44IRAK11.16436277
45HCK1.15945250
46LYN1.14866898
47MAP3K141.14727743
48CDK191.13456469
49MARK21.09870492
50ITK1.07756796
51NLK1.07380532
52CLK11.04835068
53FGFR31.04397002
54CDC71.01801752
55WEE11.01672248
56PASK1.01021718
57MATK1.00606876
58IRAK20.99109601
59PRKD20.98699465
60RPS6KA40.98347065
61ACVR1B0.97934956
62ERN10.96294330
63SCYL20.96208975
64DYRK30.92939283
65JAK10.92583148
66TIE10.91607063
67MAP3K120.90324992
68TAOK20.90237391
69NEK20.89462762
70FGFR40.89160123
71BMPR20.87314455
72VRK10.87111438
73PDK10.86157931
74HIPK20.85547744
75MAP3K60.84140178
76MKNK10.82212860
77TRIB30.80848485
78CDK40.79775534
79PTK2B0.79659520
80MAP3K20.78964637
81ATR0.77125547
82STK40.76609301
83SIK20.75800100
84EIF2AK30.75302572
85SMG10.74771976
86TNIK0.73224901
87PTK60.73129332
88CDK80.73008555
89MUSK0.72087272
90PDPK10.71958058
91MAP2K40.71480939
92PIK3CG0.70805843
93CCNB10.69866261
94TESK20.67874415
95MAPK40.67795406
96WNK10.67025334
97SIK30.66685423
98TRPM70.66330842
99CSK0.66122269
100JAK20.65668460
101IRAK30.65436657
102MAPK120.64482081
103MKNK20.64283088
104STK110.63860815
105DYRK1B0.62663644
106SGK30.62359833
107FYN0.62101871
108KDR0.61072961
109PRKCQ0.61021993
110MAP3K50.60914935
111MAP2K60.58969521
112MAPKAPK30.58781025
113CHUK0.58613902
114RPS6KA60.56786702
115TLK10.55879341
116CDK70.55497760
117STK380.54364684
118ALK0.53026350
119RAF10.52386393
120BRD40.51933752
121MAPK110.50920773
122EPHB10.49776077
123SIK10.49587587
124CDK120.49057704
125RPS6KC10.48514313
126RPS6KL10.48514313
127EPHA30.48440619
128CDK90.48422178
129SGK20.48098222
130CDK60.47646283
131MAP3K70.47393330
132MAPK70.46334051
133YES10.46157379
134MAPKAPK50.46100604
135RET0.43753336
136CDC42BPA0.43003538
137MAPKAPK20.40630460
138ILK0.40416773
139MARK30.40165725
140BRSK20.39238733
141KSR10.38717799
142DAPK20.32148096
143MAP3K80.30604288
144PRKCZ0.29634097
145CAMK40.28193066

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.71575179
2Ribosome_Homo sapiens_hsa030103.62717128
3DNA replication_Homo sapiens_hsa030303.19104349
4Staphylococcus aureus infection_Homo sapiens_hsa051502.67629146
5B cell receptor signaling pathway_Homo sapiens_hsa046622.59700107
6Base excision repair_Homo sapiens_hsa034102.27547298
7Leishmaniasis_Homo sapiens_hsa051402.21513510
8Mismatch repair_Homo sapiens_hsa034302.18727952
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.10952945
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.09837922
11Measles_Homo sapiens_hsa051622.09165029
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08616874
13Antigen processing and presentation_Homo sapiens_hsa046121.95807238
14Hematopoietic cell lineage_Homo sapiens_hsa046401.92598218
15Herpes simplex infection_Homo sapiens_hsa051681.85790467
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79594567
17Homologous recombination_Homo sapiens_hsa034401.78505436
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76755083
19Spliceosome_Homo sapiens_hsa030401.69214808
20Osteoclast differentiation_Homo sapiens_hsa043801.67086664
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64246027
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.61584718
23Nucleotide excision repair_Homo sapiens_hsa034201.57694391
24Non-homologous end-joining_Homo sapiens_hsa034501.53396857
25Acute myeloid leukemia_Homo sapiens_hsa052211.48830261
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46819574
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41394992
28T cell receptor signaling pathway_Homo sapiens_hsa046601.40934476
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38644046
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35922094
31African trypanosomiasis_Homo sapiens_hsa051431.31867077
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31677760
33Hepatitis B_Homo sapiens_hsa051611.31395898
34Asthma_Homo sapiens_hsa053101.29726119
35Allograft rejection_Homo sapiens_hsa053301.29709396
36Phagosome_Homo sapiens_hsa041451.28244150
37Influenza A_Homo sapiens_hsa051641.25841306
38Platelet activation_Homo sapiens_hsa046111.24929052
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23814306
40Pyrimidine metabolism_Homo sapiens_hsa002401.23294076
41RNA degradation_Homo sapiens_hsa030181.20926935
42Shigellosis_Homo sapiens_hsa051311.20497924
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16892655
44Cell cycle_Homo sapiens_hsa041101.16436923
45Toxoplasmosis_Homo sapiens_hsa051451.14699631
46Chronic myeloid leukemia_Homo sapiens_hsa052201.08408806
47Legionellosis_Homo sapiens_hsa051341.02478494
48Apoptosis_Homo sapiens_hsa042101.02154222
49Epstein-Barr virus infection_Homo sapiens_hsa051691.01361391
50Fanconi anemia pathway_Homo sapiens_hsa034600.99874979
51Chemokine signaling pathway_Homo sapiens_hsa040620.99196541
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97136514
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94696759
54RNA transport_Homo sapiens_hsa030130.94008965
55Renal cell carcinoma_Homo sapiens_hsa052110.93639401
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93475099
57RNA polymerase_Homo sapiens_hsa030200.92510561
58Pertussis_Homo sapiens_hsa051330.91589247
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.91000631
60Viral carcinogenesis_Homo sapiens_hsa052030.90436555
61Tuberculosis_Homo sapiens_hsa051520.87644435
62p53 signaling pathway_Homo sapiens_hsa041150.86358275
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83976094
64Non-small cell lung cancer_Homo sapiens_hsa052230.83553122
65HTLV-I infection_Homo sapiens_hsa051660.83002863
66Systemic lupus erythematosus_Homo sapiens_hsa053220.81641728
67TNF signaling pathway_Homo sapiens_hsa046680.80327119
68Endocytosis_Homo sapiens_hsa041440.79298287
69Rheumatoid arthritis_Homo sapiens_hsa053230.78674743
70FoxO signaling pathway_Homo sapiens_hsa040680.78492616
71Pentose phosphate pathway_Homo sapiens_hsa000300.76737877
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76233913
73Other glycan degradation_Homo sapiens_hsa005110.75235838
74Malaria_Homo sapiens_hsa051440.75078193
75N-Glycan biosynthesis_Homo sapiens_hsa005100.74968603
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74524944
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.73714452
78Pancreatic cancer_Homo sapiens_hsa052120.73711675
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.72843759
80Endometrial cancer_Homo sapiens_hsa052130.72001159
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71612627
82Dorso-ventral axis formation_Homo sapiens_hsa043200.71504795
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69674427
84Hepatitis C_Homo sapiens_hsa051600.69358897
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69090128
86Choline metabolism in cancer_Homo sapiens_hsa052310.68655346
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.68305416
88Regulation of autophagy_Homo sapiens_hsa041400.66366893
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64860439
90One carbon pool by folate_Homo sapiens_hsa006700.64441112
91Prolactin signaling pathway_Homo sapiens_hsa049170.64136139
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63875154
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.63098177
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62762529
95Viral myocarditis_Homo sapiens_hsa054160.60397844
96Proteasome_Homo sapiens_hsa030500.60128744
97Salmonella infection_Homo sapiens_hsa051320.59919603
98mRNA surveillance pathway_Homo sapiens_hsa030150.59896271
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59736214
100Protein export_Homo sapiens_hsa030600.58897056
101Graft-versus-host disease_Homo sapiens_hsa053320.58189924
102mTOR signaling pathway_Homo sapiens_hsa041500.58088272
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57629854
104Inositol phosphate metabolism_Homo sapiens_hsa005620.57076598
105GnRH signaling pathway_Homo sapiens_hsa049120.56597927
106Caffeine metabolism_Homo sapiens_hsa002320.56367054
107Autoimmune thyroid disease_Homo sapiens_hsa053200.56247152
108MAPK signaling pathway_Homo sapiens_hsa040100.53551727
109Small cell lung cancer_Homo sapiens_hsa052220.53157452
110Purine metabolism_Homo sapiens_hsa002300.51926641
111Type II diabetes mellitus_Homo sapiens_hsa049300.51774850
112Insulin resistance_Homo sapiens_hsa049310.51552848
113Colorectal cancer_Homo sapiens_hsa052100.51019745
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.50926166
115Thyroid cancer_Homo sapiens_hsa052160.49816283
116Amoebiasis_Homo sapiens_hsa051460.47663546
117Basal transcription factors_Homo sapiens_hsa030220.47611826
118Prostate cancer_Homo sapiens_hsa052150.46578169
119Notch signaling pathway_Homo sapiens_hsa043300.46329666
120Rap1 signaling pathway_Homo sapiens_hsa040150.46062127
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46036218
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43937893
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43617382
124ErbB signaling pathway_Homo sapiens_hsa040120.43585948
125HIF-1 signaling pathway_Homo sapiens_hsa040660.42803390
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40625672
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39598947
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39135883
129Glioma_Homo sapiens_hsa052140.38053294
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.36331600
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34614179
132Lysosome_Homo sapiens_hsa041420.34572212
133Type I diabetes mellitus_Homo sapiens_hsa049400.33943509
134VEGF signaling pathway_Homo sapiens_hsa043700.33906723
135Estrogen signaling pathway_Homo sapiens_hsa049150.32888465

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