TRERF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.59952090
2negative regulation of cell killing (GO:0031342)5.30979809
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30979809
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60059122
5regulation of B cell receptor signaling pathway (GO:0050855)4.48244709
6negative thymic T cell selection (GO:0045060)4.42256174
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41546094
8negative T cell selection (GO:0043383)4.37975272
9regulation of gamma-delta T cell activation (GO:0046643)4.33526060
10modulation by symbiont of host defense response (GO:0052031)4.30549824
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30549824
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30549824
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.30549824
14modulation by symbiont of host immune response (GO:0052553)4.30549824
15positive regulation by symbiont of host defense response (GO:0052509)4.30549824
16regulation of gamma-delta T cell differentiation (GO:0045586)4.25980070
17leukocyte aggregation (GO:0070486)4.24757897
18cellular extravasation (GO:0045123)4.22149938
19antigen processing and presentation of endogenous antigen (GO:0019883)4.13543510
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08013828
21negative regulation of T cell mediated immunity (GO:0002710)3.87298399
22positive thymic T cell selection (GO:0045059)3.86927890
23T cell selection (GO:0045058)3.85471727
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81651250
25thymic T cell selection (GO:0045061)3.78829286
26positive T cell selection (GO:0043368)3.75974234
27response to interleukin-15 (GO:0070672)3.71533193
28response to peptidoglycan (GO:0032494)3.68931108
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.59238522
30activated T cell proliferation (GO:0050798)3.59213753
31regulation of B cell differentiation (GO:0045577)3.54327560
32tolerance induction (GO:0002507)3.53953977
33histone H3-K36 demethylation (GO:0070544)3.53626976
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.51242050
35detection of other organism (GO:0098543)3.49017153
36response to muramyl dipeptide (GO:0032495)3.48195683
37neutrophil activation involved in immune response (GO:0002283)3.46385811
38negative regulation of erythrocyte differentiation (GO:0045647)3.41386594
39cellular response to interleukin-15 (GO:0071350)3.39902468
40detection of bacterium (GO:0016045)3.30574567
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23712905
42positive regulation of granulocyte differentiation (GO:0030854)3.22156985
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.21753732
44regulation of tolerance induction (GO:0002643)3.21660374
45negative regulation of leukocyte mediated immunity (GO:0002704)3.20782215
46T cell migration (GO:0072678)3.17514624
47regulation of T cell tolerance induction (GO:0002664)3.16791453
48negative regulation of phagocytosis (GO:0050765)3.13984103
49macrophage activation involved in immune response (GO:0002281)3.13940844
50neutrophil mediated immunity (GO:0002446)3.12540637
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09747499
52respiratory burst (GO:0045730)3.09606424
53negative regulation of interleukin-12 production (GO:0032695)3.09496797
54positive regulation of B cell differentiation (GO:0045579)3.08226806
55interferon-gamma production (GO:0032609)3.06984261
56regulation of interferon-beta biosynthetic process (GO:0045357)3.06082850
57neutrophil activation (GO:0042119)3.04933888
58positive regulation of tolerance induction (GO:0002645)3.04812288
59germinal center formation (GO:0002467)3.03810207
60regulation of alpha-beta T cell proliferation (GO:0046640)2.99843506
61regulation of histone H3-K27 methylation (GO:0061085)2.98887491
62B cell receptor signaling pathway (GO:0050853)2.97618801
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97542705
64response to host (GO:0075136)2.97542705
65response to host defenses (GO:0052200)2.97542705
66hepatocyte apoptotic process (GO:0097284)2.92528902
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92226902
68response to host immune response (GO:0052572)2.92226902
69antigen processing and presentation via MHC class Ib (GO:0002475)2.83481135
70detection of external biotic stimulus (GO:0098581)2.82588395
71granulocyte activation (GO:0036230)2.73684767
723-UTR-mediated mRNA stabilization (GO:0070935)2.73557000
73detection of molecule of bacterial origin (GO:0032490)2.73171900
74myeloid leukocyte mediated immunity (GO:0002444)2.71459930
75T cell homeostasis (GO:0043029)2.69377108
76myeloid cell activation involved in immune response (GO:0002275)2.68804739
77negative regulation of toll-like receptor signaling pathway (GO:0034122)2.66656466
78regulation of leukocyte degranulation (GO:0043300)2.64642782
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62142390
80negative regulation of interleukin-6 production (GO:0032715)2.60815567
81regulation of mast cell degranulation (GO:0043304)2.60478434
82detection of biotic stimulus (GO:0009595)2.59030008
83natural killer cell differentiation (GO:0001779)2.58746097
84modulation by virus of host process (GO:0019054)2.56227700
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55661162
86positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54839465
87antigen receptor-mediated signaling pathway (GO:0050851)2.53452589
88regulation of interleukin-2 biosynthetic process (GO:0045076)2.53371521
89B cell homeostasis (GO:0001782)2.50611014
90T cell receptor signaling pathway (GO:0050852)2.49938275
91leukocyte degranulation (GO:0043299)2.49436827
92regulation of granulocyte differentiation (GO:0030852)2.45891810
93regulation of defense response to virus by virus (GO:0050690)2.44534789
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.43501477
95microglial cell activation (GO:0001774)2.41010780
96histone H3-K9 modification (GO:0061647)2.40242383
97histone H3-K4 trimethylation (GO:0080182)2.40135079
98response to laminar fluid shear stress (GO:0034616)2.39798217
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.38271137
100interferon-gamma secretion (GO:0072643)2.37810774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.75228286
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38581347
3MYC_22102868_ChIP-Seq_BL_Human3.89859241
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.57216776
5* VDR_21846776_ChIP-Seq_THP-1_Human3.39874208
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27538771
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.05556177
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.02300444
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85066801
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78194724
11* VDR_24763502_ChIP-Seq_THP-1_Human2.76717974
12TCF7_22412390_ChIP-Seq_EML_Mouse2.74959894
13RUNX_20019798_ChIP-Seq_JUKART_Human2.70290905
14MAF_26560356_Chip-Seq_TH1_Human2.70093132
15MYB_26560356_Chip-Seq_TH2_Human2.66600051
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57328296
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55812062
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.55287045
19* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49271240
20UTX_26944678_Chip-Seq_JUKART_Human2.43188196
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42623016
22* MYB_26560356_Chip-Seq_TH1_Human2.40140060
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40044657
24KDM2B_26808549_Chip-Seq_DND41_Human2.38397266
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35067236
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.33686449
27SPI1_23547873_ChIP-Seq_NB4_Human2.30424247
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.25899162
29* IRF8_27001747_Chip-Seq_BMDM_Mouse2.25685513
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21244116
31SCL_19346495_ChIP-Seq_HPC-7_Human2.15491120
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15305168
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.11862149
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11759876
35MAF_26560356_Chip-Seq_TH2_Human2.01648543
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93377750
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89836458
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86622997
39* KDM2B_26808549_Chip-Seq_JURKAT_Human1.86562945
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86218089
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83619319
42* SPI1_23127762_ChIP-Seq_K562_Human1.80469473
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.78939784
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78285159
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72820943
46* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70350024
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54388511
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51567460
49* VDR_24787735_ChIP-Seq_THP-1_Human1.48041494
50GATA3_27048872_Chip-Seq_THYMUS_Human1.47869337
51PU_27001747_Chip-Seq_BMDM_Mouse1.40705002
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39383279
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37480921
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37339990
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.34455604
56E2F7_22180533_ChIP-Seq_HELA_Human1.32961520
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.32608484
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31504779
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30145271
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30145271
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30145271
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29807907
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26227414
64CIITA_25753668_ChIP-Seq_RAJI_Human1.22907601
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22003787
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21238313
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15373543
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14370058
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12300178
70RACK7_27058665_Chip-Seq_MCF-7_Human1.11231303
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10275895
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10086203
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09633639
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08747586
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08168887
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08077987
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07822969
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04592473
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00965450
80NCOR1_26117541_ChIP-Seq_K562_Human1.00345247
81LXR_22292898_ChIP-Seq_THP-1_Human0.99832720
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99523151
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97128461
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97045368
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96513175
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96173033
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96162221
88* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94964282
89GATA3_26560356_Chip-Seq_TH2_Human0.94389428
90KDM2B_26808549_Chip-Seq_K562_Human0.93122146
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.91881506
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90619329
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90220416
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87532929
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87282669
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86916260
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83938618
98TFEB_21752829_ChIP-Seq_HELA_Human0.81132624
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.80542664
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80137659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.66516968
2MP0003436_decreased_susceptibility_to3.63577369
3MP0001835_abnormal_antigen_presentation3.08662221
4MP0002396_abnormal_hematopoietic_system2.93037886
5MP0003724_increased_susceptibility_to2.83701500
6MP0001800_abnormal_humoral_immune2.59374625
7MP0002009_preneoplasia2.54016673
8MP0005671_abnormal_response_to2.53482609
9MP0002419_abnormal_innate_immunity2.43018701
10MP0003303_peritoneal_inflammation2.41391076
11MP0005076_abnormal_cell_differentiation2.39131766
12MP0005000_abnormal_immune_tolerance2.35511456
13MP0002420_abnormal_adaptive_immunity2.33376743
14MP0001819_abnormal_immune_cell2.31005639
15MP0008057_abnormal_DNA_replication2.28211697
16MP0002452_abnormal_antigen_presenting2.21584195
17MP0000703_abnormal_thymus_morphology2.21399696
18MP0002723_abnormal_immune_serum2.18359078
19MP0002398_abnormal_bone_marrow2.18110607
20MP0002166_altered_tumor_susceptibility2.16780403
21MP0009278_abnormal_bone_marrow2.15037076
22MP0003300_gastrointestinal_ulcer2.12771728
23MP0005025_abnormal_response_to2.12621588
24MP0000685_abnormal_immune_system2.06349761
25MP0009333_abnormal_splenocyte_physiolog1.95165295
26MP0000716_abnormal_immune_system1.91370425
27MP0002405_respiratory_system_inflammati1.89029110
28MP0004808_abnormal_hematopoietic_stem1.84950214
29MP0005387_immune_system_phenotype1.84661489
30MP0001790_abnormal_immune_system1.84661489
31MP0004947_skin_inflammation1.83872773
32MP0002722_abnormal_immune_system1.79166659
33MP0001533_abnormal_skeleton_physiology1.75356440
34MP0000689_abnormal_spleen_morphology1.74241517
35MP0003828_pulmonary_edema1.70273880
36MP0002006_tumorigenesis1.69523600
37MP0008260_abnormal_autophagy1.66140448
38MP0003172_abnormal_lysosome_physiology1.65312281
39MP0000858_altered_metastatic_potential1.58788886
40MP0002429_abnormal_blood_cell1.56124103
41MP0005451_abnormal_body_composition1.55458939
42MP0001851_eye_inflammation1.50493270
43MP0001873_stomach_inflammation1.49707891
44MP0003705_abnormal_hypodermis_morpholog1.48248312
45MP0010155_abnormal_intestine_physiology1.45829716
46MP0003191_abnormal_cellular_cholesterol1.45375279
47MP0004381_abnormal_hair_follicle1.42138811
48MP0006082_CNS_inflammation1.41571982
49MP0005464_abnormal_platelet_physiology1.40491393
50MP0009785_altered_susceptibility_to1.38048711
51MP0002998_abnormal_bone_remodeling1.36368745
52MP0004185_abnormal_adipocyte_glucose1.35322235
53MP0004264_abnormal_extraembryonic_tissu1.35254505
54MP0001853_heart_inflammation1.30316266
55MP0003091_abnormal_cell_migration1.29455062
56MP0005310_abnormal_salivary_gland1.28302993
57MP0003787_abnormal_imprinting1.24453088
58MP0001845_abnormal_inflammatory_respons1.23364025
59MP0003866_abnormal_defecation1.21522309
60MP0002148_abnormal_hypersensitivity_rea1.20856808
61MP0003566_abnormal_cell_adhesion1.09332218
62MP0000490_abnormal_crypts_of1.06941106
63MP0002254_reproductive_system_inflammat1.03037444
64MP0005390_skeleton_phenotype1.02742312
65MP0002933_joint_inflammation1.02550569
66MP0000465_gastrointestinal_hemorrhage1.01323821
67MP0001545_abnormal_hematopoietic_system0.99826170
68MP0005397_hematopoietic_system_phenotyp0.99826170
69MP0010352_gastrointestinal_tract_polyps0.98524966
70MP0002277_abnormal_respiratory_mucosa0.98389867
71MP0003448_altered_tumor_morphology0.96649468
72MP0002877_abnormal_melanocyte_morpholog0.95858910
73MP0002019_abnormal_tumor_incidence0.95274318
74MP0008004_abnormal_stomach_pH0.94868414
75MP0000470_abnormal_stomach_morphology0.90838781
76MP0004883_abnormal_blood_vessel0.89853912
77MP0002796_impaired_skin_barrier0.84679088
78MP0008961_abnormal_basal_metabolism0.84481256
79MP0005621_abnormal_cell_physiology0.83251943
80MP0003453_abnormal_keratinocyte_physiol0.82485628
81MP0003943_abnormal_hepatobiliary_system0.78580505
82MP0005164_abnormal_response_to0.74495289
83MP0009672_abnormal_birth_weight0.72055029
84MP0010307_abnormal_tumor_latency0.70314874
85MP0008469_abnormal_protein_level0.70291334
86MP0003795_abnormal_bone_structure0.68065036
87MP0000313_abnormal_cell_death0.67101444
88MP0000015_abnormal_ear_pigmentation0.66269689
89MP0003221_abnormal_cardiomyocyte_apopto0.66229040
90MP0003077_abnormal_cell_cycle0.64293107
91MP0002060_abnormal_skin_morphology0.63802784
92MP0000350_abnormal_cell_proliferation0.62128184
93MP0005075_abnormal_melanosome_morpholog0.59519453
94MP0002132_abnormal_respiratory_system0.59403293
95MP0003111_abnormal_nucleus_morphology0.58726576
96MP0009931_abnormal_skin_appearance0.57754911
97MP0001730_embryonic_growth_arrest0.56714932
98MP0001216_abnormal_epidermal_layer0.54598935
99MP0000767_abnormal_smooth_muscle0.53374953
100MP0009115_abnormal_fat_cell0.53265703

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.83513465
2Myositis (HP:0100614)4.35838178
3Recurrent abscess formation (HP:0002722)4.12461325
4Recurrent bacterial skin infections (HP:0005406)4.11357608
5Elevated erythrocyte sedimentation rate (HP:0003565)3.88755265
6Orchitis (HP:0100796)3.76567246
7Recurrent fungal infections (HP:0002841)3.62061610
8T lymphocytopenia (HP:0005403)3.61959828
9Optic neuritis (HP:0100653)3.54609927
10Retrobulbar optic neuritis (HP:0100654)3.54609927
11Chronic mucocutaneous candidiasis (HP:0002728)3.50906906
12Recurrent cutaneous fungal infections (HP:0011370)3.50906906
13Abnormality of macrophages (HP:0004311)3.49885356
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.47955767
15Stomatitis (HP:0010280)3.20214541
16Pustule (HP:0200039)3.11162557
17Abnormality of T cell number (HP:0011839)3.10828122
18Abnormality of the fingertips (HP:0001211)3.10065254
19Recurrent skin infections (HP:0001581)2.96722661
20Meningitis (HP:0001287)2.95761523
21Panhypogammaglobulinemia (HP:0003139)2.78561900
22Recurrent viral infections (HP:0004429)2.77886565
23Subacute progressive viral hepatitis (HP:0006572)2.75873516
24Broad face (HP:0000283)2.67939428
25Encephalitis (HP:0002383)2.67900243
26Gastrointestinal infarctions (HP:0005244)2.67617965
27Chest pain (HP:0100749)2.65587565
28Gingivitis (HP:0000230)2.61734609
29Mediastinal lymphadenopathy (HP:0100721)2.58039089
30Spontaneous hematomas (HP:0007420)2.56899025
31Keratoconjunctivitis sicca (HP:0001097)2.56765456
32Increased IgE level (HP:0003212)2.55706930
33Spondylolisthesis (HP:0003302)2.53519646
34Viral hepatitis (HP:0006562)2.50504262
35Vasculitis (HP:0002633)2.48424786
36Abnormality of T cells (HP:0002843)2.46205923
37Chronic obstructive pulmonary disease (HP:0006510)2.45993773
38Obstructive lung disease (HP:0006536)2.45993773
39Recurrent gram-negative bacterial infections (HP:0005420)2.44406729
40Thrombocytosis (HP:0001894)2.42443824
41Syringomyelia (HP:0003396)2.40250156
42Spinal cord lesions (HP:0100561)2.40250156
43Gastrointestinal inflammation (HP:0004386)2.39229647
44Arterial thrombosis (HP:0004420)2.35981645
45Cellulitis (HP:0100658)2.34809414
46Keratoconjunctivitis (HP:0001096)2.34658721
47Leukocytosis (HP:0001974)2.29342512
48Hemoptysis (HP:0002105)2.27947534
49Inflammation of the large intestine (HP:0002037)2.27151788
50Lymphopenia (HP:0001888)2.26740354
51Abnormality of the columella (HP:0009929)2.23165296
52Papilledema (HP:0001085)2.21445034
53Absent frontal sinuses (HP:0002688)2.18915568
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16125824
55Pulmonary infiltrates (HP:0002113)2.14810201
56Slow saccadic eye movements (HP:0000514)2.14387706
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.11597627
58Granulocytopenia (HP:0001913)2.10683049
59Prominent nose (HP:0000448)2.09136955
60Basal cell carcinoma (HP:0002671)2.06635672
61Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.06453318
62Amaurosis fugax (HP:0100576)2.01667477
63Prolonged bleeding time (HP:0003010)1.97885974
64Long eyelashes (HP:0000527)1.96801617
65Urticaria (HP:0001025)1.94966452
66Osteomyelitis (HP:0002754)1.93506251
67Metaphyseal cupping (HP:0003021)1.91883311
68Dislocated radial head (HP:0003083)1.90704800
69Colitis (HP:0002583)1.86184164
70Obstructive sleep apnea (HP:0002870)1.85008569
71Acute myeloid leukemia (HP:0004808)1.84494855
72IgM deficiency (HP:0002850)1.82958750
73Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82902766
74Neonatal hypoglycemia (HP:0001998)1.82640919
75Abnormal platelet volume (HP:0011876)1.81887805
76Verrucae (HP:0200043)1.77876713
77Papilloma (HP:0012740)1.77876713
78Hypochromic microcytic anemia (HP:0004840)1.77654448
79Skin ulcer (HP:0200042)1.77132521
80Abnormality of the radial head (HP:0003995)1.75751061
81Micronodular cirrhosis (HP:0001413)1.75485163
82Selective tooth agenesis (HP:0001592)1.75305649
83Long palpebral fissure (HP:0000637)1.74786570
84Periodontitis (HP:0000704)1.74271095
85Anorexia (HP:0002039)1.73597996
86Abnormality of the frontal sinuses (HP:0002687)1.71973058
87Abnormality of the pericardium (HP:0001697)1.71202717
88Glomerulopathy (HP:0100820)1.70530461
89Abnormality of T cell physiology (HP:0011840)1.70255550
90Thickened calvaria (HP:0002684)1.68702168
91Bicuspid aortic valve (HP:0001647)1.66290076
92Osteolytic defects of the phalanges of the hand (HP:0009771)1.66020185
93Osteolytic defects of the hand bones (HP:0009699)1.66020185
94Fatigue (HP:0012378)1.65903608
95Persistence of primary teeth (HP:0006335)1.65131235
96Hypochromic anemia (HP:0001931)1.64899592
97Epistaxis (HP:0000421)1.64845899
98Sepsis (HP:0100806)1.64346122
99Increased cerebral lipofuscin (HP:0011813)1.64139121
100Microcytic anemia (HP:0001935)1.62626080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.78872174
2PRPF4B3.44539313
3RIPK43.07392139
4CDK122.73238501
5TRIB32.57953378
6MAP2K32.43450628
7MAP3K102.32762068
8MAP3K142.26797239
9SMG12.21747188
10TYK22.05042483
11ERN11.88638285
12CSK1.87142260
13ZAP701.83835615
14SIK31.83677254
15EPHB11.80934271
16TNK21.80044762
17JAK31.77310757
18IRAK41.75496194
19FES1.74912339
20GRK61.73914218
21BLK1.71555105
22BTK1.66146990
23RIPK11.66121506
24TXK1.62356531
25BRD41.60312390
26MAP3K131.59579213
27ICK1.57622215
28IKBKE1.43725418
29JAK11.40243716
30TAOK11.37022221
31SIK11.36808027
32HCK1.35921693
33ITK1.33242794
34STK101.32936795
35YES11.32218384
36FGFR41.27829774
37PKN21.25002133
38MELK1.24890522
39PASK1.18713922
40CSF1R1.18551418
41HIPK21.17199180
42LCK1.09046625
43CDK61.04571112
44CAMK1D1.03189040
45CAMK1G0.99487654
46SYK0.98639996
47MARK20.98393850
48PRKD20.97508972
49PTK60.94362155
50TEC0.93518205
51MAP3K30.91989693
52TAOK30.89769928
53MAPK70.82840224
54CDK190.80462955
55MARK30.79927884
56RPS6KC10.78203593
57RPS6KL10.78203593
58LYN0.77609637
59TBK10.77014045
60CDK40.76574041
61JAK20.73734131
62PDK10.73525334
63MAP3K60.72362946
64IRAK20.72005687
65SIK20.66897084
66RPS6KA20.66360503
67CAMKK10.65873474
68KIT0.64892283
69NLK0.64795278
70TESK20.64247795
71CDC42BPA0.63586055
72PRKCQ0.62386116
73MAP3K10.61974795
74MTOR0.60770769
75FGFR30.60447510
76FGR0.60384435
77RPS6KA60.60278943
78PDGFRB0.58806673
79MAP2K20.58269234
80STK380.58077066
81LRRK20.57967198
82CAMKK20.56446861
83IRAK10.55504701
84TTN0.55355225
85SGK30.54442732
86IKBKB0.51430565
87CDK90.51113715
88RET0.50554620
89MAP3K70.50428594
90PIM10.48731540
91MAPKAPK20.47665473
92NEK90.47573234
93PIK3CG0.46382615
94PDPK10.44638805
95CDK70.41148910
96FLT30.40106112
97DYRK1B0.39855400
98TGFBR20.38483922
99TAOK20.38118286
100EEF2K0.36764976

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.18138216
2Osteoclast differentiation_Homo sapiens_hsa043802.12433190
3B cell receptor signaling pathway_Homo sapiens_hsa046622.11000003
4T cell receptor signaling pathway_Homo sapiens_hsa046602.09616836
5Primary immunodeficiency_Homo sapiens_hsa053401.96252001
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93400913
7Chronic myeloid leukemia_Homo sapiens_hsa052201.79173244
8Leishmaniasis_Homo sapiens_hsa051401.77309540
9Non-small cell lung cancer_Homo sapiens_hsa052231.76142928
10Measles_Homo sapiens_hsa051621.74558699
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74073365
12Pancreatic cancer_Homo sapiens_hsa052121.67505208
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61659595
14Hepatitis B_Homo sapiens_hsa051611.51304333
15Colorectal cancer_Homo sapiens_hsa052101.46904243
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46465146
17Notch signaling pathway_Homo sapiens_hsa043301.43792656
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.43689281
19Endometrial cancer_Homo sapiens_hsa052131.38994418
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34894349
21Tuberculosis_Homo sapiens_hsa051521.32591168
22Chemokine signaling pathway_Homo sapiens_hsa040621.31579831
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30243024
24Thyroid cancer_Homo sapiens_hsa052161.30218302
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.29889402
26Prostate cancer_Homo sapiens_hsa052151.29579932
27Herpes simplex infection_Homo sapiens_hsa051681.28310517
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27471718
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.24838622
30Influenza A_Homo sapiens_hsa051641.23949139
31TNF signaling pathway_Homo sapiens_hsa046681.23811632
32Hematopoietic cell lineage_Homo sapiens_hsa046401.22224648
33Toxoplasmosis_Homo sapiens_hsa051451.22213791
34Antigen processing and presentation_Homo sapiens_hsa046121.21983372
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19414645
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18855200
37Graft-versus-host disease_Homo sapiens_hsa053321.18525439
38Renal cell carcinoma_Homo sapiens_hsa052111.16631091
39VEGF signaling pathway_Homo sapiens_hsa043701.16336514
40Viral myocarditis_Homo sapiens_hsa054161.14855841
41Prolactin signaling pathway_Homo sapiens_hsa049171.12053177
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.11246498
43Apoptosis_Homo sapiens_hsa042101.11244861
44Platelet activation_Homo sapiens_hsa046111.10704534
45Hepatitis C_Homo sapiens_hsa051601.10113199
46Allograft rejection_Homo sapiens_hsa053301.08244755
47Shigellosis_Homo sapiens_hsa051311.07193491
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05668357
49HTLV-I infection_Homo sapiens_hsa051661.04906324
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03624322
51Autoimmune thyroid disease_Homo sapiens_hsa053201.00696801
52Malaria_Homo sapiens_hsa051440.99009007
53Inositol phosphate metabolism_Homo sapiens_hsa005620.98228957
54FoxO signaling pathway_Homo sapiens_hsa040680.98087245
55Other glycan degradation_Homo sapiens_hsa005110.97318220
56Viral carcinogenesis_Homo sapiens_hsa052030.97001979
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.95094437
58mTOR signaling pathway_Homo sapiens_hsa041500.95085966
59Epstein-Barr virus infection_Homo sapiens_hsa051690.93396336
60Choline metabolism in cancer_Homo sapiens_hsa052310.90679837
61ErbB signaling pathway_Homo sapiens_hsa040120.88667291
62Dorso-ventral axis formation_Homo sapiens_hsa043200.87119398
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.86462016
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86159480
65Glioma_Homo sapiens_hsa052140.83386516
66Estrogen signaling pathway_Homo sapiens_hsa049150.82965000
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82800392
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80828795
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80222905
70Endocytosis_Homo sapiens_hsa041440.80104180
71Legionellosis_Homo sapiens_hsa051340.79417490
72MicroRNAs in cancer_Homo sapiens_hsa052060.79053907
73Small cell lung cancer_Homo sapiens_hsa052220.78403551
74Staphylococcus aureus infection_Homo sapiens_hsa051500.74684746
75Proteoglycans in cancer_Homo sapiens_hsa052050.74085947
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73336748
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72809915
78Adherens junction_Homo sapiens_hsa045200.71761837
79Salmonella infection_Homo sapiens_hsa051320.67036910
80Rap1 signaling pathway_Homo sapiens_hsa040150.66656726
81MAPK signaling pathway_Homo sapiens_hsa040100.66414339
82Insulin resistance_Homo sapiens_hsa049310.66253538
83GnRH signaling pathway_Homo sapiens_hsa049120.65786590
84Base excision repair_Homo sapiens_hsa034100.64715956
85African trypanosomiasis_Homo sapiens_hsa051430.63890889
86Pathways in cancer_Homo sapiens_hsa052000.63886462
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62870011
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62358706
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.61163078
90Amoebiasis_Homo sapiens_hsa051460.60837348
91Type I diabetes mellitus_Homo sapiens_hsa049400.58662292
92mRNA surveillance pathway_Homo sapiens_hsa030150.58455361
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57769586
94Lysine degradation_Homo sapiens_hsa003100.57691419
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57506722
96Bladder cancer_Homo sapiens_hsa052190.55556711
97Insulin signaling pathway_Homo sapiens_hsa049100.54727286
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54417161
99Phagosome_Homo sapiens_hsa041450.53812440
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51579512

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