TREX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)9.41786813
2keratinocyte differentiation (GO:0030216)9.26199622
3multicellular organismal water homeostasis (GO:0050891)9.18300687
4hemidesmosome assembly (GO:0031581)9.09555135
5water homeostasis (GO:0030104)7.63244031
6keratinocyte proliferation (GO:0043616)7.20029360
7epidermal cell differentiation (GO:0009913)7.09290884
8epidermis development (GO:0008544)6.81150697
9intermediate filament organization (GO:0045109)6.71843836
10long-chain fatty acid biosynthetic process (GO:0042759)6.55753912
11skin morphogenesis (GO:0043589)5.95662542
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.92060743
13sphingoid metabolic process (GO:0046519)5.72288320
14proteasome assembly (GO:0043248)5.62664142
15ectoderm development (GO:0007398)5.29082387
16fatty acid elongation (GO:0030497)5.16275347
17sphingosine metabolic process (GO:0006670)4.97736273
18regulation of mitochondrial translation (GO:0070129)4.85078077
19pseudouridine synthesis (GO:0001522)4.84408522
20linoleic acid metabolic process (GO:0043651)4.80638525
21termination of RNA polymerase III transcription (GO:0006386)4.63857420
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.63857420
23diol metabolic process (GO:0034311)4.55375611
24chaperone-mediated protein transport (GO:0072321)4.54428624
25detection of bacterium (GO:0016045)4.52998594
26intermediate filament cytoskeleton organization (GO:0045104)4.49611530
27intermediate filament-based process (GO:0045103)4.37914890
28maturation of SSU-rRNA (GO:0030490)4.34891184
29ribonucleoprotein complex biogenesis (GO:0022613)4.33976334
30ribosomal large subunit biogenesis (GO:0042273)4.33667323
31regulation of ruffle assembly (GO:1900027)4.28270710
32regulation of transforming growth factor beta1 production (GO:0032908)4.28177587
33establishment of protein localization to mitochondrial membrane (GO:0090151)4.25051717
34lipoxygenase pathway (GO:0019372)4.24382935
35ribosome biogenesis (GO:0042254)4.18719033
36keratinocyte development (GO:0003334)4.18243796
37DNA replication checkpoint (GO:0000076)4.15802914
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14452479
39regulation of translational termination (GO:0006449)3.95948958
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88682398
41protein deneddylation (GO:0000338)3.87819986
42detection of other organism (GO:0098543)3.87680971
43glucosamine-containing compound catabolic process (GO:1901072)3.83639180
44rRNA processing (GO:0006364)3.81041881
45regulation of cell proliferation involved in kidney development (GO:1901722)3.80617681
46cullin deneddylation (GO:0010388)3.79523402
47protein targeting to mitochondrion (GO:0006626)3.77534650
48positive regulation of glomerulus development (GO:0090193)3.71499546
49phosphatidylinositol acyl-chain remodeling (GO:0036149)3.71389586
50cellular component biogenesis (GO:0044085)3.71253485
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.67869370
52negative regulation of ligase activity (GO:0051352)3.67869370
53rRNA metabolic process (GO:0016072)3.66818613
54chemical homeostasis within a tissue (GO:0048875)3.65054671
55ribosome assembly (GO:0042255)3.60618288
56regulation of cellular amino acid metabolic process (GO:0006521)3.57886925
57positive regulation of interleukin-8 secretion (GO:2000484)3.56669378
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54876149
59ATP synthesis coupled proton transport (GO:0015986)3.54876149
60surfactant homeostasis (GO:0043129)3.53624877
61long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.50855831
62spliceosomal snRNP assembly (GO:0000387)3.50372292
63rRNA modification (GO:0000154)3.43708282
64protein localization to mitochondrion (GO:0070585)3.42569952
65establishment of protein localization to mitochondrion (GO:0072655)3.42061512
66nucleoside salvage (GO:0043174)3.41929160
67regulation of phospholipase A2 activity (GO:0032429)3.40947552
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40660904
69virion attachment to host cell (GO:0019062)3.38658377
70adhesion of symbiont to host cell (GO:0044650)3.38658377
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37225564
72translation (GO:0006412)3.35508315
73nucleobase biosynthetic process (GO:0046112)3.35123302
74respiratory electron transport chain (GO:0022904)3.30812781
75viral transcription (GO:0019083)3.29750974
76phosphatidylserine acyl-chain remodeling (GO:0036150)3.29639100
77chromatin remodeling at centromere (GO:0031055)3.28621303
78primary alcohol catabolic process (GO:0034310)3.27279477
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26619070
80respiratory chain complex IV assembly (GO:0008535)3.24728792
81DNA damage response, detection of DNA damage (GO:0042769)3.24112416
82electron transport chain (GO:0022900)3.24004244
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23406773
84purine nucleobase biosynthetic process (GO:0009113)3.23383654
85ribosomal small subunit assembly (GO:0000028)3.23341004
86negative regulation of keratinocyte proliferation (GO:0010839)3.21789128
87CENP-A containing nucleosome assembly (GO:0034080)3.19022184
88epithelium development (GO:0060429)3.17902729
89skin development (GO:0043588)3.17057476
90water-soluble vitamin biosynthetic process (GO:0042364)3.13747112
91regulation of chemokine secretion (GO:0090196)3.13577453
92DNA deamination (GO:0045006)3.08873825
93protein neddylation (GO:0045116)3.08389320
94translational termination (GO:0006415)3.08372142
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04165014
96planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03825414
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01565734
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01565734
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01565734
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01257019
101protein complex biogenesis (GO:0070271)3.00624249
102ncRNA 3-end processing (GO:0043628)3.00097721
103rRNA methylation (GO:0031167)2.98455562
104cytochrome complex assembly (GO:0017004)2.98236179
105signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98094419
106signal transduction involved in DNA damage checkpoint (GO:0072422)2.98094419
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.97995526
108NADH dehydrogenase complex assembly (GO:0010257)2.97995526
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97995526
110signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96793239
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96793239
112mitochondrial respiratory chain complex assembly (GO:0033108)2.94936924
113cell-substrate junction assembly (GO:0007044)2.94584012
114translational initiation (GO:0006413)2.94503825
115positive regulation of chemokine secretion (GO:0090197)2.93509879
116cotranslational protein targeting to membrane (GO:0006613)2.93231106
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.92227329
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91920682
119eyelid development in camera-type eye (GO:0061029)2.91733897
120fatty-acyl-CoA metabolic process (GO:0035337)2.91703513
121antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88888436
122signal transduction involved in cell cycle checkpoint (GO:0072395)2.88691330
123ncRNA processing (GO:0034470)2.88666501
124phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.87536475
125regulation of natural killer cell differentiation (GO:0032823)2.83084323
126cyclooxygenase pathway (GO:0019371)2.82983130
127protein localization to endoplasmic reticulum (GO:0070972)2.82889677
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81514828
129gland morphogenesis (GO:0022612)2.80374987
130phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.80278574
131positive regulation of ligase activity (GO:0051351)2.80242666
132tRNA methylation (GO:0030488)2.79534884
133negative regulation of cell fate specification (GO:0009996)2.79474839
134positive regulation of monocyte chemotaxis (GO:0090026)2.79236562
135phospholipid efflux (GO:0033700)2.78148925
136fibrinolysis (GO:0042730)2.78019028
137interferon-gamma secretion (GO:0072643)2.77513129
138prostaglandin biosynthetic process (GO:0001516)2.76426531
139prostanoid biosynthetic process (GO:0046457)2.76426531
140hair follicle morphogenesis (GO:0031069)2.74502132
141regulation of interleukin-8 secretion (GO:2000482)2.74132079
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72062262
143establishment of tissue polarity (GO:0007164)2.71366150
144establishment of planar polarity (GO:0001736)2.71366150
145adhesion of symbiont to host (GO:0044406)2.70588831
146positive regulation of vesicle fusion (GO:0031340)2.69039966
147positive regulation of cholesterol efflux (GO:0010875)2.68904406
148negative regulation of stress fiber assembly (GO:0051497)2.66222179
149sphingolipid biosynthetic process (GO:0030148)2.66041885
150positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.65861664
151long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.64559482
152G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.57084977
153ribosomal small subunit biogenesis (GO:0042274)2.54939937
154atrioventricular valve morphogenesis (GO:0003181)2.53800289
155ethanol metabolic process (GO:0006067)2.53188904
156phosphatidylcholine acyl-chain remodeling (GO:0036151)2.51346617
157negative regulation of interferon-gamma production (GO:0032689)2.50521283
158positive regulation of epidermis development (GO:0045684)2.49952849
159prostanoid metabolic process (GO:0006692)2.48002469
160prostaglandin metabolic process (GO:0006693)2.48002469
161positive regulation of cholesterol transport (GO:0032376)2.46788344
162positive regulation of sterol transport (GO:0032373)2.46788344
163negative regulation of cell fate commitment (GO:0010454)2.45646368
164viral life cycle (GO:0019058)2.43570210
165regulation of cardioblast differentiation (GO:0051890)2.43223540
166SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.41097522
167regulation of glomerulus development (GO:0090192)2.40952324
168hormone catabolic process (GO:0042447)2.40744586
169protein targeting to ER (GO:0045047)2.40048289
170translational elongation (GO:0006414)2.39586272
171unsaturated fatty acid biosynthetic process (GO:0006636)2.39445366
172keratinization (GO:0031424)18.3347603
173establishment of skin barrier (GO:0061436)15.5043238
174desmosome organization (GO:0002934)13.8468334
175regulation of water loss via skin (GO:0033561)13.6545691
176molting cycle (GO:0042303)12.6136359
177hair cycle (GO:0042633)12.6136359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.46920570
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26928988
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76477628
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.49113474
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.41202504
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.40105827
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.28293003
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24137869
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13078465
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09155260
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06892609
12E2F7_22180533_ChIP-Seq_HELA_Human3.03983451
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.98943736
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94628103
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.84324016
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80998853
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76237138
18SOX9_24532713_ChIP-Seq_HFSC_Mouse2.62686791
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59333924
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46380056
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45919702
22DCP1A_22483619_ChIP-Seq_HELA_Human2.39905337
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37629924
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37118140
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36767645
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.35324773
27XRN2_22483619_ChIP-Seq_HELA_Human2.27732158
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.26903698
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24202075
30TRIM28_21343339_ChIP-Seq_HEK293_Human2.12365828
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09006011
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09006011
33ESR2_21235772_ChIP-Seq_MCF-7_Human2.05847927
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03721433
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03678170
36TP63_17297297_ChIP-ChIP_HaCaT_Human15.4470964
37FOXP3_21729870_ChIP-Seq_TREG_Human1.97492407
38VDR_23849224_ChIP-Seq_CD4+_Human1.96692589
39ZNF263_19887448_ChIP-Seq_K562_Human1.94765736
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.93068858
41GABP_19822575_ChIP-Seq_HepG2_Human1.89876621
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.85453131
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84540974
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81746771
45TTF2_22483619_ChIP-Seq_HELA_Human1.78868605
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72054251
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69765468
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69586187
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67997624
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60427740
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54588505
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.53873676
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.53173031
54SOX2_20726797_ChIP-Seq_SW620_Human1.52947443
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51272175
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.50127795
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48955910
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48616640
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47317039
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45992604
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.45590633
62* TP63_23658742_ChIP-Seq_EP156T_Human1.44128541
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43356412
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40994966
65TP63_22573176_ChIP-Seq_HFKS_Human1.40427234
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40213828
67ATF3_27146783_Chip-Seq_COLON_Human1.34752919
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34048275
69CJUN_26792858_Chip-Seq_BT549_Human1.31686762
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31455777
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.31428113
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29663677
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29564531
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29556990
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29076475
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28901553
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28557371
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28502248
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28212235
80VDR_21846776_ChIP-Seq_THP-1_Human1.27947408
81GATA6_21074721_ChIP-Seq_CACO-2_Human1.27739272
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24787376
83RACK7_27058665_Chip-Seq_MCF-7_Human1.23531854
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22098194
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21995762
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21909432
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21800349
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.20820837
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20759317
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20511881
91ELK1_19687146_ChIP-ChIP_HELA_Human1.20020598
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19658652
93* BCL6_27268052_Chip-Seq_Bcells_Human1.19324549
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19140198
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.18623713
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18313416
97CIITA_25753668_ChIP-Seq_RAJI_Human1.17906603
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16555114
99KLF5_25053715_ChIP-Seq_YYC3_Human1.15102787
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14559104
101KDM5A_27292631_Chip-Seq_BREAST_Human1.13306598
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13201813
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12937617
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12817076
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12007303
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10667230
107RXR_22108803_ChIP-Seq_LS180_Human1.08340744
108CTCF_27219007_Chip-Seq_Bcells_Human1.08340028
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06839120
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06370786
111TP53_18474530_ChIP-ChIP_U2OS_Human1.05718938
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03784007
113MAF_26560356_Chip-Seq_TH2_Human1.03674622
114ELK1_22589737_ChIP-Seq_MCF10A_Human1.02520340
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02459096
116EGR1_19032775_ChIP-ChIP_M12_Human1.02437685
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.01966401
118CEBPB_22108803_ChIP-Seq_LS180_Human1.01904914
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.01711129
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01689955
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01444944
122FOXP1_21924763_ChIP-Seq_HESCs_Human1.01079130
123GATA4_25053715_ChIP-Seq_YYC3_Human0.99741549
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99460812
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98798672
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98762143
127LXR_22292898_ChIP-Seq_THP-1_Human0.98701670
128TFEB_21752829_ChIP-Seq_HELA_Human0.96353006
129P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95540185
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95527878
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95471401
132* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95387514
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.95032012
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.95029827
135CTCF_20526341_ChIP-Seq_ESCs_Human0.93676323
136CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93597761
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.93324811
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92847104
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.92211623
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.92195159
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91712484
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.91018143
143MYC_22102868_ChIP-Seq_BL_Human0.89559962
144SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89411345
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88461878
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88227106
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88030152
148NANOG_20526341_ChIP-Seq_ESCs_Human0.87835367
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86650633
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86459539
151ELF5_23300383_ChIP-Seq_T47D_Human0.86228481
152CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85245693
153FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83619549
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83103986
155GATA6_25053715_ChIP-Seq_YYC3_Human0.82877222
156ERG_20517297_ChIP-Seq_VCAP_Human0.82053715
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.82019839
158NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78333594
159PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75835730
160* BCOR_27268052_Chip-Seq_Bcells_Human0.75794208
161RBPJ_21746931_ChIP-Seq_IB4_Human0.74763709
162AHR_22903824_ChIP-Seq_MCF-7_Human0.73303809
163AR_21572438_ChIP-Seq_LNCaP_Human0.72444578
164RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72036655
165* TAF2_19829295_ChIP-Seq_ESCs_Human0.71005278
166SOX2_27498859_Chip-Seq_STOMACH_Mouse0.70810555
167CLOCK_20551151_ChIP-Seq_293T_Human0.70497083
168* E2F1_20622854_ChIP-Seq_HELA_Human0.69795349
169BCAT_22108803_ChIP-Seq_LS180_Human0.69356804
170EZH2_27294783_Chip-Seq_ESCs_Mouse0.67886632
171P68_20966046_ChIP-Seq_HELA_Human0.67363774
172FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67274912
173JARID2_20075857_ChIP-Seq_MESCs_Mouse0.67017896
174SA1_27219007_Chip-Seq_Bcells_Human0.66720154
175ERG_21242973_ChIP-ChIP_JURKAT_Human0.66225154
176HNFA_21074721_ChIP-Seq_CACO-2_Human0.65796724
177ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.65710944
178PPARA_22158963_ChIP-Seq_LIVER_Mouse0.62813700
179SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61539968
180JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.61086180
181CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61085791
182SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.60762168
183P300_27058665_Chip-Seq_ZR-75-30cells_Human0.60759654
184TCF4_22108803_ChIP-Seq_LS180_Human0.60695393
185KDM2B_26808549_Chip-Seq_K562_Human0.60352742
186EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.60041002
187SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.59230731
188TBX20_22328084_ChIP-Seq_HEART_Mouse0.59212444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.59623253
2MP0005275_abnormal_skin_tensile6.05961481
3MP0000579_abnormal_nail_morphology4.99359554
4* MP0005501_abnormal_skin_physiology4.92353841
5MP0010234_abnormal_vibrissa_follicle4.83640976
6MP0003941_abnormal_skin_development4.66510837
7MP0004381_abnormal_hair_follicle3.83732318
8MP0001216_abnormal_epidermal_layer3.58237162
9MP0003806_abnormal_nucleotide_metabolis3.57081832
10MP0002060_abnormal_skin_morphology3.53324380
11MP0000383_abnormal_hair_follicle3.20674847
12* MP0010771_integument_phenotype3.12121269
13MP0005451_abnormal_body_composition3.11233551
14MP0010678_abnormal_skin_adnexa3.07589767
15MP0000467_abnormal_esophagus_morphology3.06758616
16MP0004947_skin_inflammation3.05894352
17MP0000647_abnormal_sebaceous_gland2.90594656
18MP0002098_abnormal_vibrissa_morphology2.85592071
19MP0002254_reproductive_system_inflammat2.83977871
20MP0003693_abnormal_embryo_hatching2.80147190
21* MP0003453_abnormal_keratinocyte_physiol2.47675991
22MP0000377_abnormal_hair_follicle2.46146628
23MP0004957_abnormal_blastocyst_morpholog2.27512910
24MP0000427_abnormal_hair_cycle2.27096914
25MP0003111_abnormal_nucleus_morphology2.27037894
26MP0003705_abnormal_hypodermis_morpholog2.22579557
27MP0010094_abnormal_chromosome_stability2.17854887
28MP0000762_abnormal_tongue_morphology2.08986247
29MP0008058_abnormal_DNA_repair2.05124396
30MP0003191_abnormal_cellular_cholesterol1.98720866
31MP0009931_abnormal_skin_appearance1.84249804
32MP0009333_abnormal_splenocyte_physiolog1.76988792
33MP0003566_abnormal_cell_adhesion1.76647704
34MP0000685_abnormal_immune_system1.72238010
35MP0003786_premature_aging1.71287241
36MP0001191_abnormal_skin_condition1.68551362
37MP0004185_abnormal_adipocyte_glucose1.65127001
38MP0002396_abnormal_hematopoietic_system1.61198611
39MP0001243_abnormal_dermal_layer1.59773092
40MP0003077_abnormal_cell_cycle1.55420117
41MP0006036_abnormal_mitochondrial_physio1.51198840
42MP0004043_abnormal_pH_regulation1.48966754
43MP0000367_abnormal_coat/_hair1.46522533
44MP0008007_abnormal_cellular_replicative1.44470441
45MP0003186_abnormal_redox_activity1.39927667
46MP0003878_abnormal_ear_physiology1.38624567
47MP0005377_hearing/vestibular/ear_phenot1.38624567
48MP0000566_synostosis1.36132364
49MP0005409_darkened_coat_color1.31842534
50MP0004885_abnormal_endolymph1.27064459
51MP0002234_abnormal_pharynx_morphology1.23949153
52MP0000015_abnormal_ear_pigmentation1.23097490
53MP0000465_gastrointestinal_hemorrhage1.22001170
54MP0001851_eye_inflammation1.21115376
55MP0006035_abnormal_mitochondrial_morpho1.20000160
56MP0002148_abnormal_hypersensitivity_rea1.19463417
57MP0004782_abnormal_surfactant_physiolog1.17436484
58MP0008932_abnormal_embryonic_tissue1.17067246
59MP0005671_abnormal_response_to1.14508376
60MP0005174_abnormal_tail_pigmentation1.13740273
61MP0001853_heart_inflammation1.10173975
62MP0001346_abnormal_lacrimal_gland1.04873083
63MP0001764_abnormal_homeostasis0.98359865
64MP0009379_abnormal_foot_pigmentation0.97375747
65* MP0002019_abnormal_tumor_incidence0.96211565
66MP0003011_delayed_dark_adaptation0.94327183
67MP0001835_abnormal_antigen_presentation0.91020960
68MP0009053_abnormal_anal_canal0.90078546
69MP0005387_immune_system_phenotype0.89763589
70MP0001790_abnormal_immune_system0.89763589
71MP0005023_abnormal_wound_healing0.89758081
72MP0001340_abnormal_eyelid_morphology0.87036726
73MP0008057_abnormal_DNA_replication0.86875555
74MP0002009_preneoplasia0.85953951
75MP0003950_abnormal_plasma_membrane0.81236530
76MP0000350_abnormal_cell_proliferation0.80952945
77MP0005310_abnormal_salivary_gland0.75514384
78MP0010352_gastrointestinal_tract_polyps0.75068466
79MP0001873_stomach_inflammation0.71681462
80MP0001800_abnormal_humoral_immune0.71094524
81MP0005000_abnormal_immune_tolerance0.71090345
82MP0001730_embryonic_growth_arrest0.70820202
83MP0000703_abnormal_thymus_morphology0.69547069
84MP0002452_abnormal_antigen_presenting0.68629261
85* MP0008873_increased_physiological_sensi0.68537647
86MP0003448_altered_tumor_morphology0.67863492
87MP0008438_abnormal_cutaneous_collagen0.66439771
88MP0000490_abnormal_crypts_of0.65962374
89MP0002723_abnormal_immune_serum0.65813704
90MP0005025_abnormal_response_to0.64163517
91MP0008260_abnormal_autophagy0.64161988
92MP0000313_abnormal_cell_death0.64071536
93MP0001819_abnormal_immune_cell0.63761950
94MP0001849_ear_inflammation0.63699340
95MP0008004_abnormal_stomach_pH0.62727966
96MP0001784_abnormal_fluid_regulation0.62703689
97MP0002420_abnormal_adaptive_immunity0.62172109
98MP0002177_abnormal_outer_ear0.62050455
99MP0001188_hyperpigmentation0.61660652
100MP0005257_abnormal_intraocular_pressure0.61470138
101MP0001661_extended_life_span0.60466019
102MP0006054_spinal_hemorrhage0.58949658
103MP0002722_abnormal_immune_system0.58913583
104MP0003279_aneurysm0.58420574
105MP0002877_abnormal_melanocyte_morpholog0.57515960
106MP0000358_abnormal_cell_content/0.57060620
107MP0002102_abnormal_ear_morphology0.56700969
108MP0002095_abnormal_skin_pigmentation0.56629431
109MP0010030_abnormal_orbit_morphology0.55400908
110MP0002282_abnormal_trachea_morphology0.50985859
111MP0003755_abnormal_palate_morphology0.49462551
112MP0000627_abnormal_mammary_gland0.48988643
113MP0005666_abnormal_adipose_tissue0.48951072
114MP0003315_abnormal_perineum_morphology0.48399089
115MP0004264_abnormal_extraembryonic_tissu0.48040008
116MP0002166_altered_tumor_susceptibility0.40519460
117MP0003436_decreased_susceptibility_to0.40463004
118MP0005076_abnormal_cell_differentiation0.38508387
119MP0004019_abnormal_vitamin_homeostasis0.38317118
120MP0002111_abnormal_tail_morphology0.38033512
121MP0005375_adipose_tissue_phenotype0.36659051
122MP0000538_abnormal_urinary_bladder0.36257079
123MP0001177_atelectasis0.34791805
124MP0002006_tumorigenesis0.33370314
125MP0000537_abnormal_urethra_morphology0.32716313
126MP0001984_abnormal_olfaction0.31497308
127MP0003329_amyloid_beta_deposits0.31178469
128MP0002277_abnormal_respiratory_mucosa0.29362199
129MP0004272_abnormal_basement_membrane0.29015760
130MP0008961_abnormal_basal_metabolism0.28723241
131MP0008789_abnormal_olfactory_epithelium0.27417067
132MP0005508_abnormal_skeleton_morphology0.26867243
133MP0005248_abnormal_Harderian_gland0.26252753
134MP0003638_abnormal_response/metabolism_0.23886918
135MP0000470_abnormal_stomach_morphology0.23791683
136MP0002249_abnormal_larynx_morphology0.23657411
137MP0010386_abnormal_urinary_bladder0.23539544
138MP0002233_abnormal_nose_morphology0.21091041
139MP0005193_abnormal_anterior_eye0.20902303
140MP0004858_abnormal_nervous_system0.20330034
141MP0002090_abnormal_vision0.20028812
142MP0009384_cardiac_valve_regurgitation0.19487520
143MP0003763_abnormal_thymus_physiology0.18557118
144MP0005388_respiratory_system_phenotype0.18367453
145MP0002133_abnormal_respiratory_system0.18367453
146MP0002896_abnormal_bone_mineralization0.17901680
147MP0000750_abnormal_muscle_regeneration0.17569307
148MP0000432_abnormal_head_morphology0.17482472
149MP0003136_yellow_coat_color0.17079839
150MP0004197_abnormal_fetal_growth/weight/0.16173348
151MP0005390_skeleton_phenotype0.15560080
152MP0001533_abnormal_skeleton_physiology0.15073178
153MP0000013_abnormal_adipose_tissue0.14278870
154MP0000613_abnormal_salivary_gland0.14237214

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.37700014
2Increased IgE level (HP:0003212)7.36235397
3Plantar hyperkeratosis (HP:0007556)7.15062890
4Palmoplantar hyperkeratosis (HP:0000972)7.01765589
5Congenital ichthyosiform erythroderma (HP:0007431)6.83617532
6Thick nail (HP:0001805)6.63313164
7Palmar hyperkeratosis (HP:0010765)6.60238010
8Woolly hair (HP:0002224)6.52734254
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.29034102
10Fragile nails (HP:0001808)5.95212331
11Erythema (HP:0010783)5.90661879
12Onycholysis (HP:0001806)5.84859620
13Erythroderma (HP:0001019)5.46557329
14Right ventricular cardiomyopathy (HP:0011663)5.40630746
15Alopecia of scalp (HP:0002293)4.83201272
16Milia (HP:0001056)4.69811208
17Abnormal blistering of the skin (HP:0008066)4.66419169
18Oral leukoplakia (HP:0002745)4.61560625
19Gangrene (HP:0100758)4.47114803
20Conjunctival hamartoma (HP:0100780)4.46700939
21Pili torti (HP:0003777)4.44244531
22Ectropion (HP:0000656)4.36847801
23Parakeratosis (HP:0001036)4.36523736
24Lip pit (HP:0100267)4.36299304
25Nail dystrophy (HP:0008404)4.14998015
26Corneal erosion (HP:0200020)4.06972241
27Abnormality of placental membranes (HP:0011409)4.05032258
28Amniotic constriction ring (HP:0009775)4.05032258
29Pustule (HP:0200039)4.00524316
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.98370971
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.98370971
32Follicular hyperkeratosis (HP:0007502)3.82387054
33Hypohidrosis (HP:0000966)3.81479486
34Palmoplantar keratoderma (HP:0000982)3.77494966
35Hyporeflexia of lower limbs (HP:0002600)3.55644454
36Acute necrotizing encephalopathy (HP:0006965)3.41930590
37Pruritus (HP:0000989)3.37474748
38Mitochondrial inheritance (HP:0001427)3.29908003
39Ridged nail (HP:0001807)3.17132143
40Abnormal mitochondria in muscle tissue (HP:0008316)3.14457876
41Hepatocellular necrosis (HP:0001404)3.13284803
42Sparse eyelashes (HP:0000653)3.06186837
43Increased CSF lactate (HP:0002490)2.96633762
44Curly hair (HP:0002212)2.91252103
45Hepatic necrosis (HP:0002605)2.87301025
46Distal lower limb muscle weakness (HP:0009053)2.85131984
47Progressive macrocephaly (HP:0004481)2.79386970
48Abnormal hair laboratory examination (HP:0003328)2.79273243
49Acute encephalopathy (HP:0006846)2.72827117
50Natal tooth (HP:0000695)2.72353876
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69899885
52Hamartoma of the eye (HP:0010568)2.66309387
53Ventricular tachycardia (HP:0004756)2.64742472
54Advanced eruption of teeth (HP:0006288)2.61940639
55Furrowed tongue (HP:0000221)2.60539023
56Lack of skin elasticity (HP:0100679)2.59491841
57Squamous cell carcinoma (HP:0002860)2.52589334
58Brittle hair (HP:0002299)2.50369857
59Macrocytic anemia (HP:0001972)2.47142294
60Atrophic scars (HP:0001075)2.46835684
61Abnormal number of erythroid precursors (HP:0012131)2.44898565
62Laryngomalacia (HP:0001601)2.43069287
63Abnormality of secondary sexual hair (HP:0009888)2.41370120
64Abnormality of the axillary hair (HP:0100134)2.41370120
65Abnormality of the neuromuscular junction (HP:0003398)2.40783245
66Fatigable weakness (HP:0003473)2.40783245
673-Methylglutaconic aciduria (HP:0003535)2.38367417
68Selective tooth agenesis (HP:0001592)2.35050223
69Increased serum lactate (HP:0002151)2.33186228
70Corneal dystrophy (HP:0001131)2.32815429
71Rough bone trabeculation (HP:0100670)2.32523656
72Abnormality of the salivary glands (HP:0010286)2.26910511
73Increased hepatocellular lipid droplets (HP:0006565)2.26859289
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25945801
75Acanthosis nigricans (HP:0000956)2.25722359
76Hyperhidrosis (HP:0000975)2.24660835
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23880424
78Abnormalities of placenta or umbilical cord (HP:0001194)2.23540769
79Respiratory failure (HP:0002878)2.23388408
80Popliteal pterygium (HP:0009756)2.21699231
81Congenital, generalized hypertrichosis (HP:0004540)2.21406201
82Testicular atrophy (HP:0000029)2.20943556
83Hypergammaglobulinemia (HP:0010702)2.19986185
84Areflexia of lower limbs (HP:0002522)2.19192532
85Cerebral edema (HP:0002181)2.19136370
86Sparse scalp hair (HP:0002209)2.16191333
87Lactic acidosis (HP:0003128)2.15861522
88Type I transferrin isoform profile (HP:0003642)2.14720411
89Abnormality of cells of the erythroid lineage (HP:0012130)2.10390969
90Anonychia (HP:0001798)2.10144107
91Megaloblastic anemia (HP:0001889)2.08647094
92Progressive muscle weakness (HP:0003323)2.07844280
93Methylmalonic aciduria (HP:0012120)2.07799945
94Round ear (HP:0100830)2.07597216
95Dehydration (HP:0001944)2.06088925
96Methylmalonic acidemia (HP:0002912)2.04102112
97Increased connective tissue (HP:0009025)2.03991413
98Premature ovarian failure (HP:0008209)2.03829584
99Microretrognathia (HP:0000308)2.00842284
100Reticulocytopenia (HP:0001896)2.00668327
101Opisthotonus (HP:0002179)2.00659872
102Microvesicular hepatic steatosis (HP:0001414)2.00046664
103Abnormality of nail color (HP:0100643)10.1081760
104Type 1 muscle fiber predominance (HP:0003803)1.99542907
105Dry skin (HP:0000958)1.98970272
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.97753863
107Degeneration of anterior horn cells (HP:0002398)1.97206416
108Abnormality of the anterior horn cell (HP:0006802)1.97206416
109Homocystinuria (HP:0002156)1.96484180
110Abnormality of homocysteine metabolism (HP:0010919)1.96484180
111Eczematoid dermatitis (HP:0000976)1.94531623
112Muscle fiber inclusion bodies (HP:0100299)1.93627935
113Axonal loss (HP:0003447)1.92690318
114Cerebral hypomyelination (HP:0006808)1.91829308
115Villous atrophy (HP:0011473)1.90089718
116Abnormality of small intestinal villus morphology (HP:0011472)1.90089718
117Lipid accumulation in hepatocytes (HP:0006561)1.89452832
118Cleft eyelid (HP:0000625)1.87011654
119Myopathic facies (HP:0002058)1.86434313
120Blepharitis (HP:0000498)1.86411256
121Paralysis (HP:0003470)1.85013281
122Renal Fanconi syndrome (HP:0001994)1.84846598
123Nemaline bodies (HP:0003798)1.84426073
124Exercise intolerance (HP:0003546)1.83489397
125Panhypogammaglobulinemia (HP:0003139)1.83296909
126Increased intramyocellular lipid droplets (HP:0012240)1.83133951
127Distal arthrogryposis (HP:0005684)1.82945314
128Multiple enchondromatosis (HP:0005701)1.82374281
129Skin ulcer (HP:0200042)1.81904687
130Reduced antithrombin III activity (HP:0001976)1.81450384
131Concave nail (HP:0001598)1.81135117
132Abnormal trabecular bone morphology (HP:0100671)1.80431893
133Malignant hyperthermia (HP:0002047)1.78662604
134Papilloma (HP:0012740)1.78084149
135Verrucae (HP:0200043)1.78084149
136Hypoplastic labia majora (HP:0000059)1.77420990
137Pancytopenia (HP:0001876)1.77303199
138Achilles tendon contracture (HP:0001771)1.74163747
139Ventricular fibrillation (HP:0001663)1.72287547
140Exercise-induced myalgia (HP:0003738)1.71672061
141Trismus (HP:0000211)1.66751881
142Slow-growing hair (HP:0002217)1.66049656
143Abnormality of hair growth rate (HP:0011363)1.66049656
144Abnormality of the fingernails (HP:0001231)1.65916428
145Carious teeth (HP:0000670)1.64653505
146Severe Myopia (HP:0011003)1.64479172
147Pterygium (HP:0001059)1.63585658
148Neck muscle weakness (HP:0000467)1.63549996
149Sepsis (HP:0100806)1.62822268
150Aplasia cutis congenita (HP:0001057)1.59480548
151Abnormality of the Achilles tendon (HP:0005109)1.59135923
152Abnormality of the labia majora (HP:0012881)1.58726170
153Abnormal hemoglobin (HP:0011902)1.56083775
154Sudden death (HP:0001699)1.53327748
155Down-sloping shoulders (HP:0200021)1.52733805
156Abnormality of the gastric mucosa (HP:0004295)1.51410098
157Absent eyelashes (HP:0000561)1.47025969
158Fragile skin (HP:0001030)1.46539456
159Muscle fiber splitting (HP:0003555)1.46231759
160Aplasia involving bones of the extremities (HP:0009825)1.42600713
161Aplasia of the phalanges of the hand (HP:0009802)1.42600713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.50943238
2MAPKAPK35.01118892
3TLK14.97346028
4MAP3K34.55276824
5FER4.12280338
6NME24.02152576
7ERN13.74443332
8MST43.67357081
9MST1R3.26589144
10MAP3K23.23893684
11STK163.20948673
12VRK23.20051942
13TESK22.81046000
14PIK3CG2.80115299
15IRAK32.65982146
16RPS6KB22.54153506
17EIF2AK12.51672444
18EPHA22.40412665
19PIM22.13333092
20ZAK2.05675057
21PBK2.01823166
22SRPK12.00124184
23MAP3K111.93688643
24MUSK1.92900112
25TESK11.91979371
26TXK1.87308826
27TTN1.86965883
28STK241.70071125
29TRPM71.61990546
30EPHB21.60684381
31LRRK21.59620447
32FGFR11.57313296
33MAP3K61.54249253
34TAOK11.54143200
35EIF2AK31.52400977
36PDK21.52340756
37TSSK61.51558410
38GRK61.47504129
39MAP2K61.45305975
40LATS11.44648012
41PLK41.44075935
42NEK11.43380610
43IRAK21.43246227
44BCKDK1.42783663
45PTK61.41766491
46CDC71.36153549
47ERBB31.33523007
48LIMK11.31127594
49IKBKB1.30817287
50ABL21.28505038
51BLK1.28173325
52MAPKAPK51.26207442
53MAP3K121.24288949
54RIPK11.23702528
55TRIB31.22791086
56MAP2K31.17903454
57EPHB11.12379616
58FGFR41.12103929
59MAP3K11.09402968
60TTK1.09128556
61MAP4K11.05739216
62MAP3K71.05171653
63OBSCN1.04987060
64VRK11.04324625
65STK101.03897440
66DYRK1B1.02169302
67EPHA30.99883509
68MAP2K40.96269873
69IKBKE0.95699153
70TGFBR20.94436165
71CSNK1G30.92911740
72BCR0.92816292
73FGFR20.92181577
74LATS20.90313303
75SMG10.89900129
76MET0.89760885
77RPS6KA40.89247465
78MAPKAPK20.88869995
79NUAK10.87143220
80NME10.86806793
81PLK10.86729653
82JAK30.86090237
83TNK20.85044125
84TGFBR10.84474904
85IRAK40.84236595
86PLK30.83728695
87PAK40.82086218
88CSNK1G10.80439549
89CDK60.77874344
90ILK0.76666090
91TYK20.76116023
92PRKD10.74644887
93EEF2K0.74607108
94ITK0.73446799
95CSNK1A1L0.72194330
96BRSK10.71939964
97ATR0.71540296
98MAP3K100.71132120
99FGFR30.71069665
100TAOK20.68799199
101DYRK30.68272378
102AURKB0.66161527
103BMX0.65475314
104MAP3K140.65178064
105EIF2AK20.62624623
106NTRK20.61193398
107MAP2K10.59861941
108PTK20.58504764
109PKN20.57917523
110DMPK0.57273618
111ADRBK20.57239934
112CSNK1G20.57033895
113MAP3K50.55131032
114CDK30.54960192
115MAPK150.53739231
116AURKA0.53654846
117NEK20.52575480
118CDK40.51576874
119CSNK2A20.48840160
120CSNK2A10.47904212
121DAPK10.46892985
122FGR0.46563489
123CHEK10.45139001
124ADRBK10.44974999
125KDR0.44848326
126ROCK10.44812136
127PRKCI0.44484674
128CHEK20.44140637
129GRK70.43864892
130MELK0.41483263
131KIT0.41438760
132BRSK20.41304909
133CDK70.39860638
134SIK10.39451897
135MAP3K90.38255237
136MAP2K20.37225568
137PDGFRA0.35974191
138ROCK20.35627105
139STK40.35198387
140HCK0.34150185
141PASK0.34074989
142TIE10.33870586
143TYRO30.32921479
144RPS6KA10.31352179
145PAK30.30320284
146MAPK120.29526650
147PKN10.29292738
148PRPF4B0.29180459
149TBK10.28490806
150JAK20.28248158
151MAP3K80.27592070
152PHKG10.26920762
153PHKG20.26920762
154SCYL20.26612729
155MAPK40.26081596
156SRC0.25199710
157PRKCE0.24946915
158STK110.23341414
159DDR20.23229591
160CSNK1D0.22581432
161BTK0.22389764
162RIPK40.21017353
163MARK20.20232636
164PRKD20.20067601
165HIPK20.18902815
166ERBB20.18672939
167GSK3A0.18298555
168SYK0.18141452
169EGFR0.17241470

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.79984898
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63352575
3Linoleic acid metabolism_Homo sapiens_hsa005913.62744249
4Sphingolipid metabolism_Homo sapiens_hsa006003.60589970
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.59233596
6RNA polymerase_Homo sapiens_hsa030203.54798287
7Cyanoamino acid metabolism_Homo sapiens_hsa004603.50638105
8Arachidonic acid metabolism_Homo sapiens_hsa005903.30928601
9Oxidative phosphorylation_Homo sapiens_hsa001903.25847155
10DNA replication_Homo sapiens_hsa030303.25130186
11Sulfur relay system_Homo sapiens_hsa041222.97945611
12Fatty acid elongation_Homo sapiens_hsa000622.96090614
13Ribosome_Homo sapiens_hsa030102.72192621
14Mismatch repair_Homo sapiens_hsa034302.62374811
15Parkinsons disease_Homo sapiens_hsa050122.61751282
16Spliceosome_Homo sapiens_hsa030402.52439576
17Histidine metabolism_Homo sapiens_hsa003402.48751884
18Phenylalanine metabolism_Homo sapiens_hsa003602.46177940
19Base excision repair_Homo sapiens_hsa034102.42046227
20Homologous recombination_Homo sapiens_hsa034402.38092325
21Ether lipid metabolism_Homo sapiens_hsa005652.26092891
22Pyrimidine metabolism_Homo sapiens_hsa002402.24749058
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18309916
24One carbon pool by folate_Homo sapiens_hsa006701.94332984
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92638545
26Huntingtons disease_Homo sapiens_hsa050161.90306799
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87669684
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79896469
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74519273
30Alzheimers disease_Homo sapiens_hsa050101.72257579
31Fat digestion and absorption_Homo sapiens_hsa049751.71430848
32VEGF signaling pathway_Homo sapiens_hsa043701.63302399
33RNA transport_Homo sapiens_hsa030131.61044371
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60768561
35Fanconi anemia pathway_Homo sapiens_hsa034601.59041672
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58760358
37Nucleotide excision repair_Homo sapiens_hsa034201.56350649
38Staphylococcus aureus infection_Homo sapiens_hsa051501.50812294
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49945333
40Tight junction_Homo sapiens_hsa045301.47454539
41Retinol metabolism_Homo sapiens_hsa008301.36778829
42RNA degradation_Homo sapiens_hsa030181.36413428
43Adherens junction_Homo sapiens_hsa045201.36343218
44Basal transcription factors_Homo sapiens_hsa030221.33899639
45Tyrosine metabolism_Homo sapiens_hsa003501.32284892
46Protein export_Homo sapiens_hsa030601.30633568
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27154377
48Chemical carcinogenesis_Homo sapiens_hsa052041.26581158
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26027590
50ECM-receptor interaction_Homo sapiens_hsa045121.25820754
51Vitamin B6 metabolism_Homo sapiens_hsa007501.25334209
52Sphingolipid signaling pathway_Homo sapiens_hsa040711.23842000
53Purine metabolism_Homo sapiens_hsa002301.23767641
54Basal cell carcinoma_Homo sapiens_hsa052171.19945014
55GnRH signaling pathway_Homo sapiens_hsa049121.14093718
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13429395
57Folate biosynthesis_Homo sapiens_hsa007901.13174472
58Sulfur metabolism_Homo sapiens_hsa009201.06961881
59Non-homologous end-joining_Homo sapiens_hsa034501.06059379
60Pertussis_Homo sapiens_hsa051331.05048249
61Proteoglycans in cancer_Homo sapiens_hsa052051.03819811
62ABC transporters_Homo sapiens_hsa020101.03755284
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03489099
64Primary immunodeficiency_Homo sapiens_hsa053401.03260683
65Epstein-Barr virus infection_Homo sapiens_hsa051691.01160650
66Axon guidance_Homo sapiens_hsa043601.00761262
67Bladder cancer_Homo sapiens_hsa052190.98884354
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97082379
69Amoebiasis_Homo sapiens_hsa051460.95712597
70Cell cycle_Homo sapiens_hsa041100.95486783
71beta-Alanine metabolism_Homo sapiens_hsa004100.93762609
72Pancreatic secretion_Homo sapiens_hsa049720.93069294
73Vitamin digestion and absorption_Homo sapiens_hsa049770.92278149
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.90633620
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.89091820
76Renin secretion_Homo sapiens_hsa049240.87728531
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86577426
78Serotonergic synapse_Homo sapiens_hsa047260.86076753
79Hippo signaling pathway_Homo sapiens_hsa043900.83104208
80Melanogenesis_Homo sapiens_hsa049160.81366376
81Hepatitis C_Homo sapiens_hsa051600.80401342
82Hedgehog signaling pathway_Homo sapiens_hsa043400.79727886
83Toxoplasmosis_Homo sapiens_hsa051450.79167197
84Pyruvate metabolism_Homo sapiens_hsa006200.78719576
85Mineral absorption_Homo sapiens_hsa049780.76103219
86Platelet activation_Homo sapiens_hsa046110.75736104
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74108286
88p53 signaling pathway_Homo sapiens_hsa041150.74073445
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.72992178
90Selenocompound metabolism_Homo sapiens_hsa004500.72278347
91Long-term depression_Homo sapiens_hsa047300.70899870
92Caffeine metabolism_Homo sapiens_hsa002320.67725211
93Ras signaling pathway_Homo sapiens_hsa040140.67008014
94Fatty acid biosynthesis_Homo sapiens_hsa000610.66680478
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.65110482
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64894031
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63468343
98Herpes simplex infection_Homo sapiens_hsa051680.63345136
99Salmonella infection_Homo sapiens_hsa051320.62880371
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62666764
101Metabolic pathways_Homo sapiens_hsa011000.62126735
102Glutathione metabolism_Homo sapiens_hsa004800.60683125
103Galactose metabolism_Homo sapiens_hsa000520.60511097
104Steroid biosynthesis_Homo sapiens_hsa001000.60411158
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59456867
106Phototransduction_Homo sapiens_hsa047440.59218958
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.58646722
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58433412
109ErbB signaling pathway_Homo sapiens_hsa040120.57393079
110MicroRNAs in cancer_Homo sapiens_hsa052060.57095081
111Salivary secretion_Homo sapiens_hsa049700.56957146
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.56424579
113Gastric acid secretion_Homo sapiens_hsa049710.55720942
114Tuberculosis_Homo sapiens_hsa051520.55597339
115Antigen processing and presentation_Homo sapiens_hsa046120.55483789
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54780699
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54512661
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52592757
119Dorso-ventral axis formation_Homo sapiens_hsa043200.51942998
120Protein digestion and absorption_Homo sapiens_hsa049740.49598847
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49108412
122Shigellosis_Homo sapiens_hsa051310.48889538
123Acute myeloid leukemia_Homo sapiens_hsa052210.48629175
124Collecting duct acid secretion_Homo sapiens_hsa049660.48607510
125TNF signaling pathway_Homo sapiens_hsa046680.47174621
126PPAR signaling pathway_Homo sapiens_hsa033200.47025549
127Malaria_Homo sapiens_hsa051440.45986658
128Graft-versus-host disease_Homo sapiens_hsa053320.45364966
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44003648
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43702036
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43655203
132Other glycan degradation_Homo sapiens_hsa005110.43330174
133Oxytocin signaling pathway_Homo sapiens_hsa049210.42711641
134Focal adhesion_Homo sapiens_hsa045100.42419324
135Endocytosis_Homo sapiens_hsa041440.41944629
136Thyroid cancer_Homo sapiens_hsa052160.41895322
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.40788896
138Rap1 signaling pathway_Homo sapiens_hsa040150.40776648
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40142683
140Allograft rejection_Homo sapiens_hsa053300.39809775
141Fructose and mannose metabolism_Homo sapiens_hsa000510.38462125
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38289253
143Insulin resistance_Homo sapiens_hsa049310.37872886
144Dilated cardiomyopathy_Homo sapiens_hsa054140.37630701
145Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37586793
146Autoimmune thyroid disease_Homo sapiens_hsa053200.37444291
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.36368680
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.36073787
149N-Glycan biosynthesis_Homo sapiens_hsa005100.36056492
150Wnt signaling pathway_Homo sapiens_hsa043100.35054051
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34013846
152Long-term potentiation_Homo sapiens_hsa047200.33716746
153Legionellosis_Homo sapiens_hsa051340.32811845
154Phagosome_Homo sapiens_hsa041450.31811374
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31504711
156Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31136610
157Estrogen signaling pathway_Homo sapiens_hsa049150.31117191
158Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29824457
159Glioma_Homo sapiens_hsa052140.29817054
160Carbon metabolism_Homo sapiens_hsa012000.28495486
161HTLV-I infection_Homo sapiens_hsa051660.27058252
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26779425
163Regulation of autophagy_Homo sapiens_hsa041400.24357101
164Cardiac muscle contraction_Homo sapiens_hsa042600.23990082
165Rheumatoid arthritis_Homo sapiens_hsa053230.22973448
166Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22730570
167Biosynthesis of amino acids_Homo sapiens_hsa012300.21740259
168Measles_Homo sapiens_hsa051620.21308916
169Peroxisome_Homo sapiens_hsa041460.21301138
170Apoptosis_Homo sapiens_hsa042100.19522927
171Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19014637
172Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18139913
173Type I diabetes mellitus_Homo sapiens_hsa049400.17121562
174mRNA surveillance pathway_Homo sapiens_hsa030150.16866791
175Glycosaminoglycan degradation_Homo sapiens_hsa005310.14124238
176Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13149648
177Lysosome_Homo sapiens_hsa041420.10345196
1782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08930581
179Influenza A_Homo sapiens_hsa051640.07033685
180Asthma_Homo sapiens_hsa053100.06376282
181Vibrio cholerae infection_Homo sapiens_hsa051100.05474784

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