TRGC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.82574654
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.82574654
3regulation of B cell receptor signaling pathway (GO:0050855)5.58902631
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.42973107
5cellular response to interleukin-15 (GO:0071350)5.40464478
6positive regulation of gamma-delta T cell activation (GO:0046645)5.30673903
7negative T cell selection (GO:0043383)5.13874145
8response to interleukin-15 (GO:0070672)4.89109287
9negative thymic T cell selection (GO:0045060)4.88854693
10regulation of gamma-delta T cell differentiation (GO:0045586)4.70015130
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59285484
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.50188128
13activated T cell proliferation (GO:0050798)4.49612867
14cellular extravasation (GO:0045123)4.43790774
15regulation of gamma-delta T cell activation (GO:0046643)4.38083056
16antigen processing and presentation of endogenous antigen (GO:0019883)4.31721402
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.20851481
18regulation of natural killer cell mediated immunity (GO:0002715)4.20851481
19positive T cell selection (GO:0043368)4.13035090
20positive thymic T cell selection (GO:0045059)4.11991979
21regulation of T cell mediated cytotoxicity (GO:0001914)4.08660811
22positive regulation of T cell mediated cytotoxicity (GO:0001916)4.07314676
23positive regulation of natural killer cell mediated immunity (GO:0002717)4.06096633
24regulation of leukocyte mediated cytotoxicity (GO:0001910)3.99454663
25positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.97332320
26negative regulation of T cell mediated immunity (GO:0002710)3.91429874
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90860747
28leukocyte aggregation (GO:0070486)3.89154491
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.87668934
30T cell migration (GO:0072678)3.82831843
31neutrophil mediated immunity (GO:0002446)3.82354668
32positive regulation of granulocyte differentiation (GO:0030854)3.80438790
33DNA deamination (GO:0045006)3.74872466
34positive regulation of defense response to virus by host (GO:0002230)3.73417593
35mast cell activation (GO:0045576)3.73048789
36interferon-gamma production (GO:0032609)3.66875879
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.66743016
38regulation of cell killing (GO:0031341)3.65106724
39T cell selection (GO:0045058)3.64768428
40thymic T cell selection (GO:0045061)3.63053574
41positive regulation of cell killing (GO:0031343)3.60596168
42cytidine metabolic process (GO:0046087)3.49136909
43cytidine catabolic process (GO:0006216)3.49136909
44cytidine deamination (GO:0009972)3.49136909
45regulation of memory T cell differentiation (GO:0043380)3.48925009
46regulation of activation of Janus kinase activity (GO:0010533)3.47090694
47neutrophil activation involved in immune response (GO:0002283)3.45875642
48regulation of alpha-beta T cell proliferation (GO:0046640)3.45760200
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.39365771
50myeloid leukocyte mediated immunity (GO:0002444)3.39173145
51negative regulation of leukocyte mediated immunity (GO:0002704)3.36160821
52neutrophil activation (GO:0042119)3.35884508
53regulation of B cell differentiation (GO:0045577)3.34646176
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29300500
55microglial cell activation (GO:0001774)3.27650932
56leukocyte degranulation (GO:0043299)3.27447336
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26069637
58antigen processing and presentation via MHC class Ib (GO:0002475)3.24502608
59negative regulation of interleukin-12 production (GO:0032695)3.24208675
60modulation of growth of symbiont involved in interaction with host (GO:0044144)3.22071340
61regulation of growth of symbiont in host (GO:0044126)3.22071340
62negative regulation of growth of symbiont in host (GO:0044130)3.22071340
63negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.22071340
64regulation of regulatory T cell differentiation (GO:0045589)3.19761959
65pyrimidine ribonucleoside catabolic process (GO:0046133)3.19076287
66positive regulation of T cell mediated immunity (GO:0002711)3.17696162
67positive regulation of tolerance induction (GO:0002645)3.17134385
68regulation of T cell mediated immunity (GO:0002709)3.16224782
69mast cell degranulation (GO:0043303)3.11862174
70mast cell activation involved in immune response (GO:0002279)3.11862174
71positive regulation of B cell differentiation (GO:0045579)3.10542509
72alpha-beta T cell differentiation (GO:0046632)3.10030958
73granulocyte activation (GO:0036230)3.07000135
74positive regulation of interleukin-17 production (GO:0032740)3.04087599
75positive regulation of lymphocyte mediated immunity (GO:0002708)3.01148268
76regulation of tolerance induction (GO:0002643)2.97556874
77regulation of T cell tolerance induction (GO:0002664)2.96670539
78myeloid cell activation involved in immune response (GO:0002275)2.96294630
79natural killer cell activation (GO:0030101)2.96176209
80T-helper cell differentiation (GO:0042093)2.94629262
81CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.94629262
82T cell proliferation (GO:0042098)2.93960042
83alpha-beta T cell activation (GO:0046631)2.92207244
84B cell receptor signaling pathway (GO:0050853)2.91410713
85type I interferon signaling pathway (GO:0060337)2.90572911
86cellular response to type I interferon (GO:0071357)2.90572911
87negative regulation of innate immune response (GO:0045824)2.90524623
88response to type I interferon (GO:0034340)2.89779684
89regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89436283
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89138147
91dendritic cell chemotaxis (GO:0002407)2.88677117
92regulation of lymphocyte mediated immunity (GO:0002706)2.88573008
93positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.86462745
94response to muramyl dipeptide (GO:0032495)2.85387566
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.85245694
96antigen receptor-mediated signaling pathway (GO:0050851)2.85187603
97cellular defense response (GO:0006968)2.84275187
98positive regulation of T cell chemotaxis (GO:0010820)2.84074544
99regulation of T cell chemotaxis (GO:0010819)2.84074544
100T cell receptor signaling pathway (GO:0050852)2.84043970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.85601910
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.52730022
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.76921215
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71320991
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02584475
6RUNX_20019798_ChIP-Seq_JUKART_Human3.65911917
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.53633438
8MYB_26560356_Chip-Seq_TH2_Human3.36373775
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32135154
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21109503
11SCL_19346495_ChIP-Seq_HPC-7_Human3.08896192
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04908216
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87905962
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73222541
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64293337
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.62844383
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59249108
18MYB_26560356_Chip-Seq_TH1_Human2.56341285
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48952732
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42293703
21SPI1_23547873_ChIP-Seq_NB4_Human2.41967440
22GATA3_27048872_Chip-Seq_THYMUS_Human2.40772734
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.37554898
24MAF_26560356_Chip-Seq_TH1_Human2.33963449
25UTX_26944678_Chip-Seq_JUKART_Human2.21416335
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18998669
27VDR_24763502_ChIP-Seq_THP-1_Human2.11104943
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10002209
29GATA3_26560356_Chip-Seq_TH2_Human2.07040925
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01013276
31VDR_21846776_ChIP-Seq_THP-1_Human1.82435210
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80128834
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.78518024
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75384481
35SPI1_23127762_ChIP-Seq_K562_Human1.73890337
36MAF_26560356_Chip-Seq_TH2_Human1.73319210
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71150107
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70341850
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.67665237
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58601697
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.58217888
42VDR_24787735_ChIP-Seq_THP-1_Human1.56598340
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55171055
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53406886
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.47490159
46MYC_22102868_ChIP-Seq_BL_Human1.45848048
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36369229
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36354464
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36183445
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29512573
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28342703
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27368972
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24380851
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19873213
55TCF7_22412390_ChIP-Seq_EML_Mouse1.19036460
56PU_27001747_Chip-Seq_BMDM_Mouse1.17784016
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16264600
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.14511579
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.11578586
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09267685
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07723982
62VDR_23849224_ChIP-Seq_CD4+_Human1.05098019
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03491533
64GATA1_22025678_ChIP-Seq_K562_Human1.03453673
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02734806
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02287145
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99439784
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99425224
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98158428
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97876114
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97798511
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96715723
73GATA3_26560356_Chip-Seq_TH1_Human0.96333643
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94818421
75EGR1_19032775_ChIP-ChIP_M12_Human0.94066233
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.93663962
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93405748
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91416373
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90240817
80SMRT_27268052_Chip-Seq_Bcells_Human0.89781866
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88764370
82GATA1_19941826_ChIP-Seq_K562_Human0.88543682
83IRF1_19129219_ChIP-ChIP_H3396_Human0.87799873
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86965016
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85362423
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85295167
87CIITA_25753668_ChIP-Seq_RAJI_Human0.84729855
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83744381
89BCL6_27268052_Chip-Seq_Bcells_Human0.82641377
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82346470
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82230558
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81339477
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.80736554
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80240088
95GATA2_19941826_ChIP-Seq_K562_Human0.80027436
96FOXP3_21729870_ChIP-Seq_TREG_Human0.79509810
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78141178
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77799520
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76009147
100STAT1_20625510_ChIP-Seq_HELA_Human0.75330737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.55912433
2MP0003763_abnormal_thymus_physiology3.82275528
3MP0001835_abnormal_antigen_presentation3.71537017
4MP0003724_increased_susceptibility_to3.33387102
5MP0003436_decreased_susceptibility_to3.24473422
6MP0006082_CNS_inflammation3.06412279
7MP0005000_abnormal_immune_tolerance3.02558468
8MP0001800_abnormal_humoral_immune2.99748847
9MP0009785_altered_susceptibility_to2.96228829
10MP0000685_abnormal_immune_system2.83889341
11MP0005025_abnormal_response_to2.78991040
12MP0002723_abnormal_immune_serum2.72010850
13MP0002420_abnormal_adaptive_immunity2.68051884
14MP0001819_abnormal_immune_cell2.65401852
15MP0002419_abnormal_innate_immunity2.62844142
16MP0002166_altered_tumor_susceptibility2.57332461
17MP0002148_abnormal_hypersensitivity_rea2.49022827
18MP0002452_abnormal_antigen_presenting2.47519718
19MP0001790_abnormal_immune_system2.41878310
20MP0005387_immune_system_phenotype2.41878310
21MP0002405_respiratory_system_inflammati2.27779902
22MP0002398_abnormal_bone_marrow2.27716349
23MP0003303_peritoneal_inflammation2.14586442
24MP0000716_abnormal_immune_system2.14083532
25MP0000703_abnormal_thymus_morphology2.04986562
26MP0009333_abnormal_splenocyte_physiolog2.04971442
27MP0005464_abnormal_platelet_physiology1.95532973
28MP0002009_preneoplasia1.94076347
29MP0010155_abnormal_intestine_physiology1.91724428
30MP0002722_abnormal_immune_system1.91056361
31MP0003866_abnormal_defecation1.89955177
32MP0000689_abnormal_spleen_morphology1.89133398
33MP0001845_abnormal_inflammatory_respons1.83945281
34MP0002006_tumorigenesis1.82153797
35MP0004947_skin_inflammation1.81952326
36MP0005310_abnormal_salivary_gland1.75240115
37MP0002429_abnormal_blood_cell1.70587000
38MP0005075_abnormal_melanosome_morpholog1.65037163
39MP0001873_stomach_inflammation1.64778740
40MP0000465_gastrointestinal_hemorrhage1.62967490
41MP0001533_abnormal_skeleton_physiology1.59956887
42MP0009764_decreased_sensitivity_to1.40608701
43MP0004381_abnormal_hair_follicle1.40458266
44MP0003300_gastrointestinal_ulcer1.38675783
45MP0005083_abnormal_biliary_tract1.37182157
46MP0001851_eye_inflammation1.36529351
47MP0008469_abnormal_protein_level1.32528506
48MP0001853_heart_inflammation1.26573605
49MP0002396_abnormal_hematopoietic_system1.25325876
50MP0005167_abnormal_blood-brain_barrier1.23657537
51MP0002876_abnormal_thyroid_physiology1.17968692
52MP0002933_joint_inflammation1.14283472
53MP0003183_abnormal_peptide_metabolism1.10667737
54MP0004043_abnormal_pH_regulation1.09551035
55MP0003172_abnormal_lysosome_physiology1.08717281
56MP0000858_altered_metastatic_potential1.04210899
57MP0002998_abnormal_bone_remodeling1.03897369
58MP0009763_increased_sensitivity_to1.02889963
59MP0002132_abnormal_respiratory_system0.96960392
60MP0000569_abnormal_digit_pigmentation0.96898648
61MP0006054_spinal_hemorrhage0.93872366
62MP0002163_abnormal_gland_morphology0.89212182
63MP0003252_abnormal_bile_duct0.88237866
64MP0002019_abnormal_tumor_incidence0.87715355
65MP0001765_abnormal_ion_homeostasis0.84833326
66MP0010307_abnormal_tumor_latency0.84261704
67MP0002277_abnormal_respiratory_mucosa0.83512950
68MP0003448_altered_tumor_morphology0.82236439
69MP0003045_fibrosis0.82188114
70MP0008961_abnormal_basal_metabolism0.80199293
71MP0004808_abnormal_hematopoietic_stem0.77593132
72MP0009765_abnormal_xenobiotic_induced0.75983760
73MP0000249_abnormal_blood_vessel0.74161029
74MP0001919_abnormal_reproductive_system0.72806972
75MP0003656_abnormal_erythrocyte_physiolo0.71759922
76MP0009278_abnormal_bone_marrow0.71633456
77MP0003828_pulmonary_edema0.70856860
78MP0005164_abnormal_response_to0.67419642
79MP0003195_calcinosis0.66116732
80MP0004883_abnormal_blood_vessel0.65585867
81MP0005397_hematopoietic_system_phenotyp0.64517912
82MP0001545_abnormal_hematopoietic_system0.64517912
83MP0000015_abnormal_ear_pigmentation0.62693105
84MP0005174_abnormal_tail_pigmentation0.62458801
85MP0001663_abnormal_digestive_system0.60654498
86MP0001501_abnormal_sleep_pattern0.60488436
87MP0008873_increased_physiological_sensi0.60390401
88MP0003795_abnormal_bone_structure0.60137005
89MP0005390_skeleton_phenotype0.58444689
90MP0003191_abnormal_cellular_cholesterol0.58108008
91MP0008877_abnormal_DNA_methylation0.57268606
92MP0001348_abnormal_lacrimal_gland0.57233719
93MP0005166_decreased_susceptibility_to0.56730944
94MP0004147_increased_porphyrin_level0.55788268
95MP0002693_abnormal_pancreas_physiology0.55679783
96MP0002136_abnormal_kidney_physiology0.53373923
97MP0005319_abnormal_enzyme/_coenzyme0.52374282
98MP0002877_abnormal_melanocyte_morpholog0.52359248
99MP0005389_reproductive_system_phenotype0.51455926
100MP0008057_abnormal_DNA_replication0.51177443

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.03399487
2Abnormality of T cell number (HP:0011839)5.99723748
3Myositis (HP:0100614)5.08957192
4Retrobulbar optic neuritis (HP:0100654)4.92220742
5Optic neuritis (HP:0100653)4.92220742
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.76916918
7Severe combined immunodeficiency (HP:0004430)4.76864783
8Autoimmune hemolytic anemia (HP:0001890)4.73440469
9Abnormality of T cells (HP:0002843)4.68077626
10Abnormality of eosinophils (HP:0001879)4.55450176
11Orchitis (HP:0100796)4.50553874
12Stomatitis (HP:0010280)4.28773892
13Eosinophilia (HP:0001880)4.23876132
14Recurrent fungal infections (HP:0002841)4.22736058
15Encephalitis (HP:0002383)4.15653233
16Granulocytopenia (HP:0001913)4.11933902
17Elevated erythrocyte sedimentation rate (HP:0003565)4.11712974
18Pulmonary infiltrates (HP:0002113)4.08009429
19Eczematoid dermatitis (HP:0000976)4.01305278
20IgG deficiency (HP:0004315)4.01199956
21Autoimmune thrombocytopenia (HP:0001973)3.86796651
22Chronic mucocutaneous candidiasis (HP:0002728)3.85980097
23Recurrent cutaneous fungal infections (HP:0011370)3.85980097
24Meningitis (HP:0001287)3.77939304
25Combined immunodeficiency (HP:0005387)3.76925360
26Leukocytosis (HP:0001974)3.75955895
27Abnormality of T cell physiology (HP:0011840)3.67779237
28Keratoconjunctivitis (HP:0001096)3.63719728
29Mediastinal lymphadenopathy (HP:0100721)3.63302324
30Increased IgM level (HP:0003496)3.61735275
31Keratoconjunctivitis sicca (HP:0001097)3.53448734
32Vasculitis (HP:0002633)3.50617920
33Recurrent bacterial skin infections (HP:0005406)3.49126714
34Recurrent abscess formation (HP:0002722)3.48754423
35Abnormality of the prostate (HP:0008775)3.42702177
36Panhypogammaglobulinemia (HP:0003139)3.37338694
37Thyroiditis (HP:0100646)3.36620077
38Hemoptysis (HP:0002105)3.35562871
39Chronic obstructive pulmonary disease (HP:0006510)3.29185727
40Obstructive lung disease (HP:0006536)3.29185727
41Recurrent viral infections (HP:0004429)3.26431180
42Gastrointestinal infarctions (HP:0005244)3.21070043
43Abnormality of B cell number (HP:0010975)3.17136381
44Recurrent bronchitis (HP:0002837)3.05577960
45Arterial thrombosis (HP:0004420)3.03487286
46Abnormality of macrophages (HP:0004311)2.99708026
47Joint swelling (HP:0001386)2.98108339
48Pulmonary embolism (HP:0002204)2.94751917
49Pustule (HP:0200039)2.93715595
50Chest pain (HP:0100749)2.93434257
51Recurrent skin infections (HP:0001581)2.90935924
52Gangrene (HP:0100758)2.87026352
53B lymphocytopenia (HP:0010976)2.81507559
54Chronic diarrhea (HP:0002028)2.76452191
55Hypergammaglobulinemia (HP:0010702)2.74256589
56Hypoproteinemia (HP:0003075)2.69814667
57Anorexia (HP:0002039)2.63945192
58Agammaglobulinemia (HP:0004432)2.63566587
59Hypoplasia of the thymus (HP:0000778)2.58187748
60Abnormality of the pleura (HP:0002103)2.53821529
61Increased IgE level (HP:0003212)2.42974283
62Prostate neoplasm (HP:0100787)2.42028342
63Spontaneous hematomas (HP:0007420)2.38322645
64IgM deficiency (HP:0002850)2.33734841
65Epistaxis (HP:0000421)2.29570399
66Hypochromic anemia (HP:0001931)2.27871448
67Glomerulopathy (HP:0100820)2.26360280
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.26132408
69Lymphopenia (HP:0001888)2.19517204
70Stomach cancer (HP:0012126)2.19134858
71Inflammation of the large intestine (HP:0002037)2.19068800
72Keratitis (HP:0000491)2.17709529
73Urticaria (HP:0001025)2.15192855
74Thrombocytosis (HP:0001894)2.13894724
75Polyneuropathy (HP:0001271)2.10695411
76Prolonged bleeding time (HP:0003010)2.09825697
77Gastrointestinal inflammation (HP:0004386)2.07440372
78Pulmonary fibrosis (HP:0002206)2.04081478
79Neoplasm of the tracheobronchial system (HP:0100552)2.03730887
80Thrombophlebitis (HP:0004418)2.02492264
81Alveolar cell carcinoma (HP:0006519)2.01293888
82Aplasia/Hypoplasia of the thymus (HP:0010515)2.00820328
83Lymphoma (HP:0002665)2.00121929
84Abnormality of male internal genitalia (HP:0000022)1.99790301
85Gingival bleeding (HP:0000225)1.98294359
86Ureteral stenosis (HP:0000071)1.95827419
87Abnormality of the pericardium (HP:0001697)1.94320839
88Papilledema (HP:0001085)1.92722230
89Recurrent gram-negative bacterial infections (HP:0005420)1.92710122
90Acute hepatic failure (HP:0006554)1.91212846
91Skin rash (HP:0000988)1.90913962
92Vertigo (HP:0002321)1.88593493
93Hemiplegia (HP:0002301)1.87866169
94Ureteral obstruction (HP:0006000)1.87651747
95Abnormality of liposaccharide metabolism (HP:0010968)1.86955691
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.86955691
97Abnormality of glycolipid metabolism (HP:0010969)1.86955691
98Gingivitis (HP:0000230)1.85893117
99Bronchitis (HP:0012387)1.84586148
100Sepsis (HP:0100806)1.83895240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.20541309
2FES3.94591161
3MAP4K13.73980424
4TAOK33.02449356
5RIPK42.93613905
6MAP3K142.93014081
7GRK62.56246216
8TESK22.34308929
9IKBKE2.19935883
10TNK22.07651283
11CSK2.05050291
12ZAP702.04414391
13JAK11.98784713
14BTK1.87518145
15KIT1.81001399
16IKBKB1.78307240
17ITK1.76726247
18SYK1.76471440
19TBK11.67269445
20TEC1.66459800
21CAMKK21.64491069
22BMPR21.62133069
23TYK21.49559969
24LCK1.45203941
25GRK71.44931086
26JAK31.42140079
27NUAK11.38981090
28TGFBR21.37933923
29IRAK41.36588584
30LYN1.33316410
31HCK1.32530581
32MAP3K131.31420700
33MARK31.30828572
34MATK1.29860663
35BLK1.23470767
36NLK1.21345676
37KDR1.16499815
38MAP2K31.11435503
39STK101.09004053
40PIK3CG1.06946825
41EPHA31.06172478
42CSF1R1.04721017
43PRKCQ1.02355482
44PIM11.00183288
45MAP2K20.97902327
46TLK10.93198372
47EPHB10.92790337
48SIK30.92163116
49CHUK0.85940479
50HIPK20.84545650
51AKT30.81303136
52PRPF4B0.80819701
53CAMKK10.79938572
54MAP2K60.79182667
55MAP3K110.70913354
56JAK20.70888943
57CAMK1D0.69429943
58IRAK10.68704264
59FGR0.68629408
60ADRBK20.68094958
61FRK0.66145346
62PDK10.63879538
63ZAK0.61247768
64MAPK110.59676073
65ERN10.57693369
66TAOK10.55428543
67CDK40.54688752
68LRRK20.50933812
69MAPKAPK20.50137484
70MST40.49057843
71EIF2AK20.49037860
72MUSK0.48416057
73TRPM70.48010724
74FGFR30.47664877
75MAP3K70.46405640
76FYN0.46196700
77WNK40.43279685
78GRK50.43088787
79MARK20.42773002
80CLK10.41895016
81MAP3K30.41709413
82CDK60.40845808
83MAPK70.39633009
84VRK10.39429869
85IGF1R0.37751939
86CCNB10.37733571
87FGFR40.34071695
88IRAK30.33920297
89MAP3K10.33323634
90MAPK120.33040623
91NEK20.32915973
92BCKDK0.32593978
93MOS0.32466695
94ABL10.30672051
95CDK30.29745041
96MAPK40.28960998
97NEK60.28302388
98YES10.25592336
99RPS6KA60.24805696
100SIK20.24790471

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.32899519
2Graft-versus-host disease_Homo sapiens_hsa053323.85473336
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.63507816
4T cell receptor signaling pathway_Homo sapiens_hsa046602.78981390
5Allograft rejection_Homo sapiens_hsa053302.77905581
6Antigen processing and presentation_Homo sapiens_hsa046122.77797474
7Autoimmune thyroid disease_Homo sapiens_hsa053202.64967972
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60295518
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.45814693
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31889448
11Measles_Homo sapiens_hsa051622.29553999
12Osteoclast differentiation_Homo sapiens_hsa043802.18387160
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14656868
14Hematopoietic cell lineage_Homo sapiens_hsa046402.13108526
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09903659
16B cell receptor signaling pathway_Homo sapiens_hsa046622.09036792
17Leishmaniasis_Homo sapiens_hsa051402.05913624
18Type I diabetes mellitus_Homo sapiens_hsa049402.01991037
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77660020
20Asthma_Homo sapiens_hsa053101.72847201
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.72333106
22Malaria_Homo sapiens_hsa051441.68951747
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.63156585
24TNF signaling pathway_Homo sapiens_hsa046681.62074620
25Acute myeloid leukemia_Homo sapiens_hsa052211.55957461
26Herpes simplex infection_Homo sapiens_hsa051681.44956031
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44455554
28Staphylococcus aureus infection_Homo sapiens_hsa051501.40842995
29Rheumatoid arthritis_Homo sapiens_hsa053231.34777620
30Chemokine signaling pathway_Homo sapiens_hsa040621.29402576
31Tuberculosis_Homo sapiens_hsa051521.26688813
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26449917
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26338872
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25020586
35Influenza A_Homo sapiens_hsa051641.24760643
36Hepatitis B_Homo sapiens_hsa051611.20524543
37Viral myocarditis_Homo sapiens_hsa054161.19755858
38Legionellosis_Homo sapiens_hsa051341.16900060
39Apoptosis_Homo sapiens_hsa042101.08294744
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07706754
41Toxoplasmosis_Homo sapiens_hsa051451.00404014
42African trypanosomiasis_Homo sapiens_hsa051431.00386509
43Platelet activation_Homo sapiens_hsa046110.96592217
44Shigellosis_Homo sapiens_hsa051310.94400151
45Non-small cell lung cancer_Homo sapiens_hsa052230.87345586
46Viral carcinogenesis_Homo sapiens_hsa052030.86069192
47Pertussis_Homo sapiens_hsa051330.84177614
48Renin-angiotensin system_Homo sapiens_hsa046140.78385079
49Other glycan degradation_Homo sapiens_hsa005110.77926800
50Pancreatic cancer_Homo sapiens_hsa052120.77577179
51Epstein-Barr virus infection_Homo sapiens_hsa051690.73757333
52Hepatitis C_Homo sapiens_hsa051600.71909875
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.67834461
54Systemic lupus erythematosus_Homo sapiens_hsa053220.65064473
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64174984
56Salmonella infection_Homo sapiens_hsa051320.63528327
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62497935
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62061144
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59195240
60VEGF signaling pathway_Homo sapiens_hsa043700.58991056
61HTLV-I infection_Homo sapiens_hsa051660.58247627
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56247951
63Lysosome_Homo sapiens_hsa041420.54841900
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54787303
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.54644264
66Prostate cancer_Homo sapiens_hsa052150.53348448
67Prolactin signaling pathway_Homo sapiens_hsa049170.52679275
68FoxO signaling pathway_Homo sapiens_hsa040680.52366878
69Chronic myeloid leukemia_Homo sapiens_hsa052200.46448182
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.46150611
71Regulation of autophagy_Homo sapiens_hsa041400.42062334
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41951590
73Phagosome_Homo sapiens_hsa041450.41237783
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40375980
75MAPK signaling pathway_Homo sapiens_hsa040100.37644601
76Insulin resistance_Homo sapiens_hsa049310.32772272
77Arachidonic acid metabolism_Homo sapiens_hsa005900.32144102
78Endocytosis_Homo sapiens_hsa041440.31993678
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.29338410
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.29270312
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28854383
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28797807
83Dorso-ventral axis formation_Homo sapiens_hsa043200.28280988
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28265899
85Colorectal cancer_Homo sapiens_hsa052100.27459080
86Linoleic acid metabolism_Homo sapiens_hsa005910.27197243
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.24181279
88mTOR signaling pathway_Homo sapiens_hsa041500.22939025
89Olfactory transduction_Homo sapiens_hsa047400.19515670
90Peroxisome_Homo sapiens_hsa041460.19305655
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19081980
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18325212
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18056655
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16520922
95Choline metabolism in cancer_Homo sapiens_hsa052310.14625790
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.14120413
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13625936
98Nitrogen metabolism_Homo sapiens_hsa009100.13156206
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.12937535
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12403271

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