TRGC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.30356185
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.28117692
3cytidine metabolic process (GO:0046087)6.20248928
4cytidine catabolic process (GO:0006216)6.20248928
5cytidine deamination (GO:0009972)6.20248928
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.18155895
7negative regulation of cell killing (GO:0031342)6.18155895
8cellular response to interleukin-15 (GO:0071350)5.95730680
9response to interleukin-15 (GO:0070672)5.67641194
10regulation of B cell receptor signaling pathway (GO:0050855)5.64920427
11pyrimidine ribonucleoside catabolic process (GO:0046133)5.63174387
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.56775795
13negative T cell selection (GO:0043383)5.48368877
14positive thymic T cell selection (GO:0045059)5.43252121
15DNA deamination (GO:0045006)5.35722507
16positive regulation of natural killer cell mediated immunity (GO:0002717)5.35325669
17regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.30550101
18regulation of natural killer cell mediated immunity (GO:0002715)5.30550101
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.25273747
20regulation of gamma-delta T cell differentiation (GO:0045586)5.24418133
21positive T cell selection (GO:0043368)5.21274969
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.09575320
23negative thymic T cell selection (GO:0045060)5.07772759
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98628502
25positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.85518057
26activated T cell proliferation (GO:0050798)4.82490349
27regulation of gamma-delta T cell activation (GO:0046643)4.76830505
28regulation of leukocyte mediated cytotoxicity (GO:0001910)4.69207557
29antigen processing and presentation of endogenous antigen (GO:0019883)4.63095545
30thymic T cell selection (GO:0045061)4.48163462
31T cell migration (GO:0072678)4.46994444
32regulation of regulatory T cell differentiation (GO:0045589)4.46393001
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45911490
34positive regulation of T cell mediated cytotoxicity (GO:0001916)4.35748940
35positive regulation of cell killing (GO:0031343)4.35603997
36regulation of T cell mediated cytotoxicity (GO:0001914)4.28662745
37T cell selection (GO:0045058)4.27415029
38regulation of cell killing (GO:0031341)4.23353599
39regulation of T cell tolerance induction (GO:0002664)4.20313854
40leukocyte aggregation (GO:0070486)4.17141578
41regulation of activation of Janus kinase activity (GO:0010533)4.16160490
42positive regulation of tolerance induction (GO:0002645)4.05082024
43Arp2/3 complex-mediated actin nucleation (GO:0034314)4.02738439
44negative regulation of T cell apoptotic process (GO:0070233)3.77443999
45regulation of tolerance induction (GO:0002643)3.74360898
46regulation of B cell differentiation (GO:0045577)3.73407113
47regulation of alpha-beta T cell proliferation (GO:0046640)3.72484958
48antigen processing and presentation via MHC class Ib (GO:0002475)3.69932123
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.66717383
50mast cell activation (GO:0045576)3.60582886
51negative regulation of T cell mediated immunity (GO:0002710)3.60106690
52positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59031659
53T cell receptor signaling pathway (GO:0050852)3.56328795
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54206484
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.50560780
56positive regulation of B cell differentiation (GO:0045579)3.50372836
57dendritic cell chemotaxis (GO:0002407)3.49680282
58negative regulation of leukocyte mediated immunity (GO:0002704)3.49476284
59positive regulation of T cell chemotaxis (GO:0010820)3.48508634
60regulation of T cell chemotaxis (GO:0010819)3.48508634
61negative regulation of viral genome replication (GO:0045071)3.48051181
62positive regulation of defense response to virus by host (GO:0002230)3.47638003
63cellular defense response (GO:0006968)3.47572612
64regulation of lymphocyte chemotaxis (GO:1901623)3.47335805
65positive regulation of calcium-mediated signaling (GO:0050850)3.46788959
66antigen receptor-mediated signaling pathway (GO:0050851)3.45037207
67positive regulation of granulocyte differentiation (GO:0030854)3.39832325
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39261335
69actin nucleation (GO:0045010)3.35578552
70positive regulation of lymphocyte mediated immunity (GO:0002708)3.31893905
71T cell costimulation (GO:0031295)3.28693589
72leukocyte degranulation (GO:0043299)3.26616774
73lymphocyte costimulation (GO:0031294)3.24487806
74B cell receptor signaling pathway (GO:0050853)3.24441050
75granulocyte activation (GO:0036230)3.21908526
76interferon-gamma production (GO:0032609)3.21660001
77positive regulation of T cell mediated immunity (GO:0002711)3.19917799
78neutrophil activation (GO:0042119)3.19536460
79regulation of interleukin-2 biosynthetic process (GO:0045076)3.17226717
80natural killer cell activation (GO:0030101)3.16617424
81dendritic cell migration (GO:0036336)3.15924633
82negative regulation of interleukin-12 production (GO:0032695)3.13325391
83cellular extravasation (GO:0045123)3.12504198
84negative regulation by host of viral transcription (GO:0043922)3.12188132
85lymphocyte migration (GO:0072676)3.09755493
86lymphocyte chemotaxis (GO:0048247)3.09590065
87mast cell degranulation (GO:0043303)3.07311045
88mast cell activation involved in immune response (GO:0002279)3.07311045
89positive regulation of interleukin-17 production (GO:0032740)3.06217530
90regulation of lymphocyte mediated immunity (GO:0002706)3.04907289
91regulation of T cell mediated immunity (GO:0002709)3.04392239
92regulation of interleukin-12 biosynthetic process (GO:0045075)3.03471259
93regulation of T cell receptor signaling pathway (GO:0050856)3.00827450
94positive regulation of leukocyte mediated immunity (GO:0002705)3.00560287
95regulation of isotype switching to IgG isotypes (GO:0048302)2.98583175
96cytolysis (GO:0019835)2.98507366
97negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97931324
98positive regulation of lymphocyte migration (GO:2000403)2.95471529
99respiratory burst (GO:0045730)2.94811438
100type I interferon signaling pathway (GO:0060337)2.90629028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.00103127
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.99135904
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.60480064
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.15502929
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.61703029
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.87152312
7RUNX_20019798_ChIP-Seq_JUKART_Human3.84243328
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67113666
9MYB_26560356_Chip-Seq_TH2_Human3.65299514
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19246267
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.13583267
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11729870
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00970428
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77785048
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.77402891
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.72301550
17GATA3_27048872_Chip-Seq_THYMUS_Human2.68673004
18MYB_26560356_Chip-Seq_TH1_Human2.62148712
19UTX_26944678_Chip-Seq_JUKART_Human2.58476686
20MAF_26560356_Chip-Seq_TH1_Human2.50165455
21SPI1_23547873_ChIP-Seq_NB4_Human2.38704867
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.29232592
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23217982
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16397411
25GATA3_26560356_Chip-Seq_TH2_Human2.12098200
26MAF_26560356_Chip-Seq_TH2_Human2.07228852
27SCL_19346495_ChIP-Seq_HPC-7_Human2.01028173
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94203981
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92500130
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78139322
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77465785
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76617611
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.75551156
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75293651
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.75245027
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72812080
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.71926202
38VDR_24763502_ChIP-Seq_THP-1_Human1.71267104
39SPI1_23127762_ChIP-Seq_K562_Human1.64637838
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63698369
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60686864
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.57042764
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.48033728
44MYC_22102868_ChIP-Seq_BL_Human1.46277883
45VDR_21846776_ChIP-Seq_THP-1_Human1.41683181
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41071853
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33970905
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31051672
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28167092
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24688962
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20503297
52VDR_23849224_ChIP-Seq_CD4+_Human1.19828401
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17654282
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13777140
55VDR_24787735_ChIP-Seq_THP-1_Human1.13016829
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06847686
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04461037
58CIITA_25753668_ChIP-Seq_RAJI_Human1.01881487
59BCL6_27268052_Chip-Seq_Bcells_Human1.01871828
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00574552
61GATA3_26560356_Chip-Seq_TH1_Human0.99038657
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98974260
63GATA1_22025678_ChIP-Seq_K562_Human0.97804931
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96744896
65FOXP3_21729870_ChIP-Seq_TREG_Human0.95498733
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.95408402
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94158815
68HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93067631
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91674693
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91227050
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90523997
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89687979
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89033512
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88238181
75TCF7_22412390_ChIP-Seq_EML_Mouse0.88223290
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87650369
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85235856
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85229193
79PU_27001747_Chip-Seq_BMDM_Mouse0.83977994
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82829852
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82416203
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81851804
83BCOR_27268052_Chip-Seq_Bcells_Human0.80524514
84SPI1_20517297_ChIP-Seq_HL60_Human0.80211447
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80060058
86P300_27268052_Chip-Seq_Bcells_Human0.78913924
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78418911
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77893956
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76267578
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76180740
91SMRT_27268052_Chip-Seq_Bcells_Human0.75528930
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75495068
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.75362639
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74957059
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74648713
96KDM2B_26808549_Chip-Seq_DND41_Human0.74177813
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.73926601
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73671917
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72258964
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71740612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.68157152
2MP0003763_abnormal_thymus_physiology4.30776740
3MP0001835_abnormal_antigen_presentation3.98431068
4MP0009785_altered_susceptibility_to3.44631158
5MP0001800_abnormal_humoral_immune3.28001447
6MP0005000_abnormal_immune_tolerance3.26156052
7MP0003436_decreased_susceptibility_to3.16368648
8MP0003724_increased_susceptibility_to3.01648238
9MP0005025_abnormal_response_to2.98584563
10MP0002723_abnormal_immune_serum2.92557998
11MP0006082_CNS_inflammation2.90730008
12MP0002420_abnormal_adaptive_immunity2.90432668
13MP0001819_abnormal_immune_cell2.85558723
14MP0005387_immune_system_phenotype2.80378214
15MP0001790_abnormal_immune_system2.80378214
16MP0000685_abnormal_immune_system2.72521053
17MP0002148_abnormal_hypersensitivity_rea2.62733958
18MP0009333_abnormal_splenocyte_physiolog2.60222720
19MP0002452_abnormal_antigen_presenting2.57139418
20MP0002419_abnormal_innate_immunity2.51416382
21MP0002398_abnormal_bone_marrow2.43460326
22MP0002405_respiratory_system_inflammati2.40564671
23MP0003866_abnormal_defecation2.31975274
24MP0000716_abnormal_immune_system2.27901194
25MP0002166_altered_tumor_susceptibility2.23184778
26MP0000703_abnormal_thymus_morphology2.20178875
27MP0010155_abnormal_intestine_physiology2.11273683
28MP0002722_abnormal_immune_system2.03148046
29MP0000689_abnormal_spleen_morphology2.00328770
30MP0005464_abnormal_platelet_physiology1.98743912
31MP0001845_abnormal_inflammatory_respons1.91689719
32MP0002429_abnormal_blood_cell1.80296623
33MP0004947_skin_inflammation1.75243775
34MP0005075_abnormal_melanosome_morpholog1.73807545
35MP0004381_abnormal_hair_follicle1.70531481
36MP0002006_tumorigenesis1.62228294
37MP0002396_abnormal_hematopoietic_system1.61812800
38MP0001873_stomach_inflammation1.58640208
39MP0003303_peritoneal_inflammation1.49808896
40MP0001533_abnormal_skeleton_physiology1.45066907
41MP0008469_abnormal_protein_level1.41929206
42MP0002933_joint_inflammation1.40110633
43MP0001853_heart_inflammation1.38363438
44MP0003878_abnormal_ear_physiology1.30132787
45MP0005377_hearing/vestibular/ear_phenot1.30132787
46MP0009764_decreased_sensitivity_to1.29398077
47MP0003183_abnormal_peptide_metabolism1.27307847
48MP0003448_altered_tumor_morphology1.26123805
49MP0000858_altered_metastatic_potential1.24001894
50MP0000569_abnormal_digit_pigmentation1.23623507
51MP0005310_abnormal_salivary_gland1.23177703
52MP0000465_gastrointestinal_hemorrhage1.22965693
53MP0003300_gastrointestinal_ulcer1.18430565
54MP0009763_increased_sensitivity_to1.09592748
55MP0003045_fibrosis1.07812871
56MP0001851_eye_inflammation1.03268222
57MP0002277_abnormal_respiratory_mucosa0.96830401
58MP0002998_abnormal_bone_remodeling0.93433220
59MP0005174_abnormal_tail_pigmentation0.90228598
60MP0002009_preneoplasia0.89599127
61MP0002138_abnormal_hepatobiliary_system0.89326550
62MP0003172_abnormal_lysosome_physiology0.85479926
63MP0002132_abnormal_respiratory_system0.82408516
64MP0000015_abnormal_ear_pigmentation0.80936256
65MP0002019_abnormal_tumor_incidence0.80815823
66MP0009765_abnormal_xenobiotic_induced0.77925807
67MP0002163_abnormal_gland_morphology0.76995142
68MP0005166_decreased_susceptibility_to0.73921432
69MP0002877_abnormal_melanocyte_morpholog0.69292490
70MP0003786_premature_aging0.68170936
71MP0001919_abnormal_reproductive_system0.65930999
72MP0008873_increased_physiological_sensi0.65275857
73MP0004130_abnormal_muscle_cell0.62946884
74MP0001765_abnormal_ion_homeostasis0.62764812
75MP0010307_abnormal_tumor_latency0.57873977
76MP0008877_abnormal_DNA_methylation0.57872671
77MP0003252_abnormal_bile_duct0.57042725
78MP0002693_abnormal_pancreas_physiology0.56961797
79MP0003075_altered_response_to0.55998839
80MP0000490_abnormal_crypts_of0.55601913
81MP0002876_abnormal_thyroid_physiology0.54864719
82MP0005390_skeleton_phenotype0.53759446
83MP0003191_abnormal_cellular_cholesterol0.53526750
84MP0000249_abnormal_blood_vessel0.52994177
85MP0004883_abnormal_blood_vessel0.51918448
86MP0006054_spinal_hemorrhage0.50521764
87MP0001986_abnormal_taste_sensitivity0.49910510
88MP0004147_increased_porphyrin_level0.49832665
89MP0003828_pulmonary_edema0.49819504
90MP0004808_abnormal_hematopoietic_stem0.49537245
91MP0002136_abnormal_kidney_physiology0.49506403
92MP0001663_abnormal_digestive_system0.47126310
93MP0005319_abnormal_enzyme/_coenzyme0.46331250
94MP0003795_abnormal_bone_structure0.46069809
95MP0000920_abnormal_myelination0.43574684
96MP0005083_abnormal_biliary_tract0.43489270
97MP0005584_abnormal_enzyme/coenzyme_acti0.42660088
98MP0002095_abnormal_skin_pigmentation0.41320167
99MP0009643_abnormal_urine_homeostasis0.41309335
100MP0001501_abnormal_sleep_pattern0.40745125

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.89877347
2Abnormality of T cell number (HP:0011839)6.56324376
3Myositis (HP:0100614)5.17350613
4Retrobulbar optic neuritis (HP:0100654)5.05159944
5Optic neuritis (HP:0100653)5.05159944
6Abnormality of T cells (HP:0002843)4.97160276
7Severe combined immunodeficiency (HP:0004430)4.86126452
8IgG deficiency (HP:0004315)4.83379969
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.77043984
10Elevated erythrocyte sedimentation rate (HP:0003565)4.71362951
11Orchitis (HP:0100796)4.66039098
12Encephalitis (HP:0002383)4.62476953
13Increased IgM level (HP:0003496)4.52210862
14Autoimmune hemolytic anemia (HP:0001890)4.28868742
15Abnormality of eosinophils (HP:0001879)4.27505444
16Stomatitis (HP:0010280)4.24076496
17Meningitis (HP:0001287)4.19343898
18Recurrent fungal infections (HP:0002841)3.98976397
19Combined immunodeficiency (HP:0005387)3.87529065
20Eczematoid dermatitis (HP:0000976)3.85452388
21Eosinophilia (HP:0001880)3.85015255
22Granulocytopenia (HP:0001913)3.78700815
23Chronic mucocutaneous candidiasis (HP:0002728)3.75177351
24Recurrent cutaneous fungal infections (HP:0011370)3.75177351
25Keratoconjunctivitis sicca (HP:0001097)3.74664516
26Pulmonary infiltrates (HP:0002113)3.68630130
27Vasculitis (HP:0002633)3.65189400
28Leukocytosis (HP:0001974)3.62559119
29Recurrent abscess formation (HP:0002722)3.60401217
30Hypoproteinemia (HP:0003075)3.59685641
31Keratoconjunctivitis (HP:0001096)3.58461859
32Panhypogammaglobulinemia (HP:0003139)3.51839879
33Chronic diarrhea (HP:0002028)3.50385917
34Recurrent bacterial skin infections (HP:0005406)3.48915364
35Gastrointestinal infarctions (HP:0005244)3.48523180
36Recurrent bronchitis (HP:0002837)3.47371512
37Abnormality of T cell physiology (HP:0011840)3.45646161
38Abnormality of macrophages (HP:0004311)3.41712459
39Abnormality of B cell number (HP:0010975)3.39555978
40Recurrent viral infections (HP:0004429)3.39006810
41Hemoptysis (HP:0002105)3.33480071
42Thyroiditis (HP:0100646)3.33151451
43Obstructive lung disease (HP:0006536)3.30238515
44Chronic obstructive pulmonary disease (HP:0006510)3.30238515
45Mediastinal lymphadenopathy (HP:0100721)3.22877364
46Pustule (HP:0200039)3.16285373
47Lymphopenia (HP:0001888)3.14751642
48Autoimmune thrombocytopenia (HP:0001973)3.09319837
49B lymphocytopenia (HP:0010976)3.08030506
50Gangrene (HP:0100758)3.03898617
51Abnormality of cells of the lymphoid lineage (HP:0012140)3.03802644
52Recurrent skin infections (HP:0001581)2.98101184
53Chest pain (HP:0100749)2.92891615
54Abnormality of the prostate (HP:0008775)2.91815231
55Joint swelling (HP:0001386)2.89102015
56Pulmonary embolism (HP:0002204)2.87060724
57Arterial thrombosis (HP:0004420)2.78882025
58Hypergammaglobulinemia (HP:0010702)2.78533108
59Agammaglobulinemia (HP:0004432)2.76784311
60Abnormality of the pleura (HP:0002103)2.67551445
61Hypoplasia of the thymus (HP:0000778)2.67047453
62IgM deficiency (HP:0002850)2.65428609
63Anorexia (HP:0002039)2.58690226
64Acute hepatic failure (HP:0006554)2.49969953
65Increased IgE level (HP:0003212)2.43881391
66Lymphoma (HP:0002665)2.37020958
67Spontaneous hematomas (HP:0007420)2.35932598
68Hemiplegia (HP:0002301)2.35616631
69Glomerulopathy (HP:0100820)2.33593358
70Recurrent gram-negative bacterial infections (HP:0005420)2.30455980
71Aplastic anemia (HP:0001915)2.21359374
72Inflammation of the large intestine (HP:0002037)2.19309579
73Keratitis (HP:0000491)2.16395563
74Hypochromic anemia (HP:0001931)2.15520595
75Polyneuropathy (HP:0001271)2.11598751
76Epistaxis (HP:0000421)2.11133405
77Urticaria (HP:0001025)2.05457407
78Gastrointestinal inflammation (HP:0004386)2.05171907
79Bronchitis (HP:0012387)2.04564321
80Papilledema (HP:0001085)2.02404632
81Stomach cancer (HP:0012126)1.99109762
82Acne (HP:0001061)1.95489805
83Prolonged bleeding time (HP:0003010)1.94731350
84Thrombophlebitis (HP:0004418)1.93988675
853-Methylglutaconic aciduria (HP:0003535)1.92890012
86Skin rash (HP:0000988)1.91856426
87Abnormality of the pericardium (HP:0001697)1.87969733
88Pulmonary fibrosis (HP:0002206)1.87447609
89Gingivitis (HP:0000230)1.85868400
90Petechiae (HP:0000967)1.84657890
91Vertigo (HP:0002321)1.82942520
92Gingival bleeding (HP:0000225)1.80182805
93Increased CSF protein (HP:0002922)1.76822396
94Amaurosis fugax (HP:0100576)1.76453644
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.76260522
96Sepsis (HP:0100806)1.75642995
97Alveolar cell carcinoma (HP:0006519)1.73577995
98Ureteral stenosis (HP:0000071)1.73317630
99Increased serum ferritin (HP:0003281)1.71873086
100Recurrent otitis media (HP:0000403)1.68437859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.97110997
2MAP4K14.70148713
3FES3.78272810
4KDR3.07927313
5RIPK42.85868006
6TAOK32.77037783
7GRK62.72199033
8ZAP702.47509575
9TESK22.43035942
10CSK2.37352742
11ITK2.36879547
12SYK1.94162921
13BTK1.86112683
14IKBKE1.82413337
15MAP3K141.80608090
16LCK1.76037438
17JAK31.73617146
18JAK11.69690477
19GRK71.59636812
20TEC1.49591247
21BLK1.48119065
22LYN1.44719091
23TYK21.44650977
24TNK21.44330450
25TBK11.43472401
26KIT1.42742245
27IRAK41.40467273
28HCK1.37114044
29PRKCQ1.35440829
30STK101.29626128
31MARK31.24232120
32IKBKB1.22397720
33SIK31.20901946
34BCKDK1.17947124
35PIK3CG1.11653476
36TGFBR21.09385755
37MST41.09073563
38ADRBK21.05138877
39CSF1R1.01996451
40BMPR20.98920701
41MATK0.98561023
42MAP3K110.97402243
43PIM10.93137149
44TYRO30.92354528
45JAK20.90225910
46ZAK0.90220149
47MAP2K60.89381752
48MAP2K30.88156953
49NLK0.86144545
50MAP3K120.83902198
51TLK10.81867730
52PRPF4B0.71484478
53FYN0.69371610
54CAMKK20.68409914
55PIK3CA0.67830958
56CLK10.67126772
57PDK10.65950343
58NUAK10.64810134
59MAPK110.64194241
60SCYL20.62392560
61EPHB10.59977592
62MAPKAPK20.55848801
63VRK10.54077386
64MAP2K20.52413266
65FGFR40.51834860
66MAP3K30.51680932
67TRIM280.51585809
68HIPK20.51523339
69SIK20.51245260
70TESK10.50865573
71EPHA30.48700858
72TRPM70.47259729
73CDK40.46974769
74FGFR30.45189549
75IGF1R0.43452158
76TAOK10.42506425
77MAP3K130.41111144
78FGR0.40544269
79MAPK70.39283713
80IRAK10.38316837
81MAP3K10.36725560
82MAP3K50.34922662
83GRK50.33900523
84INSR0.33587871
85MAPK120.32229430
86MOS0.29074717
87CHUK0.28477710
88CAMKK10.28270468
89PDGFRB0.28153461
90EIF2AK20.27382883
91LRRK20.27191185
92ERN10.24291160
93MAPKAPK30.22968939
94MAPK30.21829626
95ABL10.21341333
96RPS6KA40.20988865
97RPS6KA50.20016922
98PRKCH0.19507839
99FRK0.17227815
100MELK0.17120855

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.58339519
2Graft-versus-host disease_Homo sapiens_hsa053324.02996688
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.88613386
4Antigen processing and presentation_Homo sapiens_hsa046123.34409425
5Autoimmune thyroid disease_Homo sapiens_hsa053203.26206780
6Allograft rejection_Homo sapiens_hsa053303.21367390
7T cell receptor signaling pathway_Homo sapiens_hsa046603.19132934
8Hematopoietic cell lineage_Homo sapiens_hsa046402.83020286
9Measles_Homo sapiens_hsa051622.42452554
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42282973
11Type I diabetes mellitus_Homo sapiens_hsa049402.40594507
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26581493
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.22330040
14Osteoclast differentiation_Homo sapiens_hsa043801.86607014
15Leishmaniasis_Homo sapiens_hsa051401.85814230
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84078811
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77333890
18Viral myocarditis_Homo sapiens_hsa054161.71676838
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68936634
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.67682928
21Rheumatoid arthritis_Homo sapiens_hsa053231.64869767
22B cell receptor signaling pathway_Homo sapiens_hsa046621.64645437
23Malaria_Homo sapiens_hsa051441.63069822
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53287475
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52403750
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50480285
27Chemokine signaling pathway_Homo sapiens_hsa040621.49416203
28Staphylococcus aureus infection_Homo sapiens_hsa051501.48815736
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.45739434
30Asthma_Homo sapiens_hsa053101.42925193
31Herpes simplex infection_Homo sapiens_hsa051681.34066473
32TNF signaling pathway_Homo sapiens_hsa046681.25841245
33Salmonella infection_Homo sapiens_hsa051321.24575076
34Proteasome_Homo sapiens_hsa030501.24213274
35Shigellosis_Homo sapiens_hsa051311.23622327
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15150914
37Acute myeloid leukemia_Homo sapiens_hsa052211.09095763
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06396445
39Apoptosis_Homo sapiens_hsa042101.02173345
40Tuberculosis_Homo sapiens_hsa051521.00714050
41Influenza A_Homo sapiens_hsa051640.99916803
42Legionellosis_Homo sapiens_hsa051340.93820975
43Epstein-Barr virus infection_Homo sapiens_hsa051690.87160797
44Hepatitis B_Homo sapiens_hsa051610.86968613
45Toxoplasmosis_Homo sapiens_hsa051450.81501639
46African trypanosomiasis_Homo sapiens_hsa051430.76369206
47Platelet activation_Homo sapiens_hsa046110.75409950
48HTLV-I infection_Homo sapiens_hsa051660.75116728
49Non-small cell lung cancer_Homo sapiens_hsa052230.70359693
50Pertussis_Homo sapiens_hsa051330.69221627
51Viral carcinogenesis_Homo sapiens_hsa052030.66111506
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63769478
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.62642973
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52983307
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50718435
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50413742
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50183836
58Endocytosis_Homo sapiens_hsa041440.48603437
59Regulation of autophagy_Homo sapiens_hsa041400.47134697
60Pancreatic cancer_Homo sapiens_hsa052120.46771540
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45206667
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44286105
63Hepatitis C_Homo sapiens_hsa051600.42936488
64Phagosome_Homo sapiens_hsa041450.42678941
65VEGF signaling pathway_Homo sapiens_hsa043700.38968801
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36189478
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35703990
68Chronic myeloid leukemia_Homo sapiens_hsa052200.33817357
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31859898
70Systemic lupus erythematosus_Homo sapiens_hsa053220.30707799
71Dorso-ventral axis formation_Homo sapiens_hsa043200.30158892
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.29126681
73Prolactin signaling pathway_Homo sapiens_hsa049170.27227951
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.26885407
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25553876
76MAPK signaling pathway_Homo sapiens_hsa040100.23841978
77Prion diseases_Homo sapiens_hsa050200.23016420
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21712417
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21570003
80Caffeine metabolism_Homo sapiens_hsa002320.19614930
81Colorectal cancer_Homo sapiens_hsa052100.17221367
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.16952563
83Lysosome_Homo sapiens_hsa041420.16013444
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15703645
85Linoleic acid metabolism_Homo sapiens_hsa005910.15682578
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13973398
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12906352
88Insulin resistance_Homo sapiens_hsa049310.11885422
89RNA polymerase_Homo sapiens_hsa030200.10713016
90FoxO signaling pathway_Homo sapiens_hsa040680.09085657
91Nitrogen metabolism_Homo sapiens_hsa009100.08201739
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.07752226
93Ras signaling pathway_Homo sapiens_hsa040140.06238671
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05763367
95Arachidonic acid metabolism_Homo sapiens_hsa005900.04970956
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.03764968
97RNA degradation_Homo sapiens_hsa030180.03583841
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.03355411
99Choline metabolism in cancer_Homo sapiens_hsa052310.02748770
100Collecting duct acid secretion_Homo sapiens_hsa049660.02433665

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