TRGJP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.92469719
2regulation of chemokine biosynthetic process (GO:0045073)6.68845700
3cellular extravasation (GO:0045123)6.68726506
4negative regulation of growth of symbiont in host (GO:0044130)6.46403689
5negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.46403689
6modulation of growth of symbiont involved in interaction with host (GO:0044144)6.46403689
7regulation of growth of symbiont in host (GO:0044126)6.46403689
8disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.37082179
9killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.37082179
10neutrophil mediated immunity (GO:0002446)6.02590872
11cytidine deamination (GO:0009972)5.78139919
12cytidine metabolic process (GO:0046087)5.78139919
13cytidine catabolic process (GO:0006216)5.78139919
14negative regulation of interleukin-8 production (GO:0032717)5.40033813
15DNA deamination (GO:0045006)5.34486823
16positive regulation of gamma-delta T cell activation (GO:0046645)5.33383018
17macrophage chemotaxis (GO:0048246)5.23999915
18regulation of interleukin-8 biosynthetic process (GO:0045414)5.12583791
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.99384191
20myeloid leukocyte mediated immunity (GO:0002444)4.70788940
21positive regulation of B cell differentiation (GO:0045579)4.61759647
22regulation of regulatory T cell differentiation (GO:0045589)4.52068250
23positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.49303765
24macrophage differentiation (GO:0030225)4.34936923
25monocyte chemotaxis (GO:0002548)4.29985598
26response to fungus (GO:0009620)4.25563757
27negative regulation of chemokine production (GO:0032682)4.24238920
28disruption of cells of other organism (GO:0044364)4.23698503
29killing of cells of other organism (GO:0031640)4.23698503
30regulation of gamma-delta T cell differentiation (GO:0045586)4.23424892
31positive regulation of interleukin-8 secretion (GO:2000484)4.16211200
32reactive oxygen species biosynthetic process (GO:1903409)4.13535895
33eosinophil chemotaxis (GO:0048245)4.12282161
34positive thymic T cell selection (GO:0045059)4.06307174
35respiratory burst (GO:0045730)3.97510725
36positive regulation of natural killer cell mediated immunity (GO:0002717)3.97231084
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.94397450
38eosinophil migration (GO:0072677)3.90651208
39negative regulation of T cell apoptotic process (GO:0070233)3.82423162
40regulation of B cell receptor signaling pathway (GO:0050855)3.76729935
41positive regulation of monocyte chemotaxis (GO:0090026)3.71287811
42regulation of gamma-delta T cell activation (GO:0046643)3.66547966
43regulation of activation of Janus kinase activity (GO:0010533)3.65440491
44inner mitochondrial membrane organization (GO:0007007)3.64804294
45defense response to fungus (GO:0050832)3.61652034
46microglial cell activation (GO:0001774)3.58482481
47regulation of B cell differentiation (GO:0045577)3.57297796
48positive regulation of chemokine biosynthetic process (GO:0045080)3.56682648
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.56280727
50regulation of natural killer cell mediated immunity (GO:0002715)3.56280727
51positive T cell selection (GO:0043368)3.47988234
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.45191416
53negative regulation by host of viral transcription (GO:0043922)3.40329456
54negative regulation of lymphocyte apoptotic process (GO:0070229)3.35235691
55DNA demethylation (GO:0080111)3.34183587
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30558450
57dendritic cell chemotaxis (GO:0002407)3.28488339
58negative regulation of bone mineralization (GO:0030502)3.26795946
59regulation of chronic inflammatory response (GO:0002676)3.26256388
60regulation of lymphocyte chemotaxis (GO:1901623)3.21648489
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17839716
62modification by host of symbiont morphology or physiology (GO:0051851)3.17521744
63regulation of MHC class II biosynthetic process (GO:0045346)3.16683775
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.13942115
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13556752
66leukocyte mediated cytotoxicity (GO:0001909)3.12722160
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.12258993
68inflammatory response to antigenic stimulus (GO:0002437)3.09561612
69T cell migration (GO:0072678)3.09327870
70interaction with symbiont (GO:0051702)3.08771333
71nucleoside diphosphate catabolic process (GO:0009134)3.07169921
72purine deoxyribonucleotide catabolic process (GO:0009155)3.06112956
73regulation of interleukin-8 secretion (GO:2000482)3.05814373
74response to interleukin-15 (GO:0070672)3.02747862
75positive regulation of cytokine biosynthetic process (GO:0042108)3.00253378
76positive regulation of interleukin-8 production (GO:0032757)2.97175372
77negative regulation of phagocytosis (GO:0050765)2.96994885
78positive regulation of interleukin-1 beta production (GO:0032731)2.96664081
79positive regulation of T cell chemotaxis (GO:0010820)2.94163868
80regulation of T cell chemotaxis (GO:0010819)2.94163868
81positive regulation of lymphocyte migration (GO:2000403)2.94062700
82regulation of interleukin-2 biosynthetic process (GO:0045076)2.93278104
83B cell receptor signaling pathway (GO:0050853)2.92879930
84DNA dealkylation (GO:0035510)2.91492716
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90776832
86positive regulation of translational initiation (GO:0045948)2.90239374
87hydrogen peroxide catabolic process (GO:0042744)2.87218335
88negative regulation of cytokine biosynthetic process (GO:0042036)2.85245768
89granulocyte activation (GO:0036230)2.82513076
90positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.82245590
91pyrimidine nucleoside catabolic process (GO:0046135)2.81610422
92positive regulation of tumor necrosis factor production (GO:0032760)2.79512869
93negative regulation of biomineral tissue development (GO:0070168)2.78604912
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77348047
95positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.74680479
96programmed necrotic cell death (GO:0097300)2.73017468
97positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.72044085
98positive regulation of T cell apoptotic process (GO:0070234)2.70361698
99iron-sulfur cluster assembly (GO:0016226)2.68974539
100metallo-sulfur cluster assembly (GO:0031163)2.68974539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.58750981
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.31944095
3VDR_21846776_ChIP-Seq_THP-1_Human4.02449099
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90765811
5SCL_19346495_ChIP-Seq_HPC-7_Human3.61337066
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.25424525
7VDR_24763502_ChIP-Seq_THP-1_Human3.16359392
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97864205
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.95127137
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93853593
11MYB_26560356_Chip-Seq_TH2_Human2.88364606
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.78858340
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.62489927
14SPI1_23547873_ChIP-Seq_NB4_Human2.62357224
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56275819
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45063016
17UTX_26944678_Chip-Seq_JUKART_Human2.41742152
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41642924
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29083131
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.22455045
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19521523
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19299794
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.16785590
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16485459
25GATA3_27048872_Chip-Seq_THYMUS_Human2.13672317
26MYB_26560356_Chip-Seq_TH1_Human2.09455322
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.06735980
28MAF_26560356_Chip-Seq_TH2_Human2.06185159
29MAF_26560356_Chip-Seq_TH1_Human2.04107192
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93283464
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87951478
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.71665373
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68599638
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64404050
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62903584
36VDR_23849224_ChIP-Seq_CD4+_Human1.59521408
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58585621
38RUNX_20019798_ChIP-Seq_JUKART_Human1.57620487
39GATA3_26560356_Chip-Seq_TH2_Human1.55214149
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52553622
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50001383
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49009294
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48449721
44FOXP3_21729870_ChIP-Seq_TREG_Human1.47616142
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45739046
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.45514155
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45416454
48SPI1_23127762_ChIP-Seq_K562_Human1.44658062
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43479217
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34591026
51STAT1_20625510_ChIP-Seq_HELA_Human1.33015719
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32444949
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31514118
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31136527
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28869691
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.28671693
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28240370
58BCL6_27268052_Chip-Seq_Bcells_Human1.26762694
59MYC_22102868_ChIP-Seq_BL_Human1.26634533
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.24982769
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23352396
62TFEB_21752829_ChIP-Seq_HELA_Human1.22896202
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21121468
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20833223
65P300_27268052_Chip-Seq_Bcells_Human1.20491380
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20228921
67SPI1_20517297_ChIP-Seq_HL60_Human1.16194918
68BCOR_27268052_Chip-Seq_Bcells_Human1.13865814
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12712072
70RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11587705
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10208962
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09751169
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08403930
74E2F7_22180533_ChIP-Seq_HELA_Human1.06637278
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.05568223
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03140939
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02735032
78GATA1_19941827_ChIP-Seq_MEL_Mouse0.99590661
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99433314
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99415462
81PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98457708
82E2F1_20622854_ChIP-Seq_HELA_Human0.98370095
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.98243199
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96604118
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95875200
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95743854
87CTCF_26484167_Chip-Seq_Bcells_Mouse0.95379047
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95149926
89GATA3_26560356_Chip-Seq_TH1_Human0.94788766
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94554683
91P68_20966046_ChIP-Seq_HELA_Human0.93682487
92VDR_24787735_ChIP-Seq_THP-1_Human0.93545127
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93125402
94TAF2_19829295_ChIP-Seq_ESCs_Human0.92927219
95CIITA_25753668_ChIP-Seq_RAJI_Human0.91973419
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91683410
97DCP1A_22483619_ChIP-Seq_HELA_Human0.86892709
98CEBPB_22108803_ChIP-Seq_LS180_Human0.86195414
99GABP_19822575_ChIP-Seq_HepG2_Human0.85932245
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85033197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.59639227
2MP0005671_abnormal_response_to4.55752407
3MP0009785_altered_susceptibility_to3.23382155
4MP0005025_abnormal_response_to3.03240034
5MP0002396_abnormal_hematopoietic_system2.95930944
6MP0003172_abnormal_lysosome_physiology2.82599707
7MP0002419_abnormal_innate_immunity2.76036402
8MP0001835_abnormal_antigen_presentation2.70916718
9MP0003763_abnormal_thymus_physiology2.68929941
10MP0001800_abnormal_humoral_immune2.48993213
11MP0005464_abnormal_platelet_physiology2.45140473
12MP0002148_abnormal_hypersensitivity_rea2.44242139
13MP0006082_CNS_inflammation2.39386397
14MP0002420_abnormal_adaptive_immunity2.38761208
15MP0003436_decreased_susceptibility_to2.32955941
16MP0001819_abnormal_immune_cell2.32291318
17MP0005000_abnormal_immune_tolerance2.28363722
18MP0005174_abnormal_tail_pigmentation2.28062281
19MP0002405_respiratory_system_inflammati2.21974667
20MP0000569_abnormal_digit_pigmentation2.18463546
21MP0002723_abnormal_immune_serum2.18360337
22MP0005075_abnormal_melanosome_morpholog2.17730395
23MP0010155_abnormal_intestine_physiology2.16357346
24MP0009333_abnormal_splenocyte_physiolog2.14879374
25MP0004147_increased_porphyrin_level2.13100133
26MP0002398_abnormal_bone_marrow2.02531849
27MP0000015_abnormal_ear_pigmentation1.95747401
28MP0000716_abnormal_immune_system1.91779133
29MP0002822_catalepsy1.90086322
30MP0002452_abnormal_antigen_presenting1.89541183
31MP0005397_hematopoietic_system_phenotyp1.88207147
32MP0001545_abnormal_hematopoietic_system1.88207147
33MP0004185_abnormal_adipocyte_glucose1.87754466
34MP0002722_abnormal_immune_system1.84620298
35MP0001845_abnormal_inflammatory_respons1.81619591
36MP0003866_abnormal_defecation1.77214452
37MP0005387_immune_system_phenotype1.77173541
38MP0001790_abnormal_immune_system1.77173541
39MP0000689_abnormal_spleen_morphology1.67302834
40MP0002429_abnormal_blood_cell1.60549640
41MP0005058_abnormal_lysosome_morphology1.60252055
42MP0001873_stomach_inflammation1.50047634
43MP0000703_abnormal_thymus_morphology1.46446624
44MP0001853_heart_inflammation1.37354872
45MP0008873_increased_physiological_sensi1.34379744
46MP0009764_decreased_sensitivity_to1.33328918
47MP0008469_abnormal_protein_level1.32751307
48MP0004808_abnormal_hematopoietic_stem1.28786737
49MP0003786_premature_aging1.27521861
50MP0001533_abnormal_skeleton_physiology1.25874279
51MP0005377_hearing/vestibular/ear_phenot1.22017348
52MP0003878_abnormal_ear_physiology1.22017348
53MP0003806_abnormal_nucleotide_metabolis1.20483736
54MP0009763_increased_sensitivity_to1.20438563
55MP0009765_abnormal_xenobiotic_induced1.14322344
56MP0009379_abnormal_foot_pigmentation1.13919943
57MP0003724_increased_susceptibility_to1.12754645
58MP0002095_abnormal_skin_pigmentation1.11489182
59MP0006036_abnormal_mitochondrial_physio1.10936481
60MP0006035_abnormal_mitochondrial_morpho1.09607181
61MP0002160_abnormal_reproductive_system1.05937662
62MP0002933_joint_inflammation1.02312055
63MP0000685_abnormal_immune_system1.01601866
64MP0000343_altered_response_to0.97632138
65MP0010307_abnormal_tumor_latency0.96712292
66MP0009278_abnormal_bone_marrow0.96287455
67MP0003075_altered_response_to0.96273091
68MP0003448_altered_tumor_morphology0.95501043
69MP0008961_abnormal_basal_metabolism0.94799470
70MP0005666_abnormal_adipose_tissue0.94409746
71MP0001851_eye_inflammation0.91160925
72MP0004134_abnormal_chest_morphology0.90273527
73MP0003656_abnormal_erythrocyte_physiolo0.90218274
74MP0000465_gastrointestinal_hemorrhage0.87493091
75MP0003011_delayed_dark_adaptation0.86060902
76MP0002019_abnormal_tumor_incidence0.84864292
77MP0001663_abnormal_digestive_system0.81952155
78MP0008007_abnormal_cellular_replicative0.81027683
79MP0004381_abnormal_hair_follicle0.79626375
80MP0000681_abnormal_thyroid_gland0.77566714
81MP0005319_abnormal_enzyme/_coenzyme0.75920499
82MP0005390_skeleton_phenotype0.72963126
83MP0002166_altered_tumor_susceptibility0.72043587
84MP0008874_decreased_physiological_sensi0.71912587
85MP0000858_altered_metastatic_potential0.71803546
86MP0004782_abnormal_surfactant_physiolog0.71383676
87MP0005310_abnormal_salivary_gland0.69570279
88MP0005220_abnormal_exocrine_pancreas0.68513504
89MP0003828_pulmonary_edema0.67954738
90MP0005389_reproductive_system_phenotype0.67416449
91MP0005164_abnormal_response_to0.67375747
92MP0004947_skin_inflammation0.64102052
93MP0003191_abnormal_cellular_cholesterol0.62894185
94MP0003183_abnormal_peptide_metabolism0.60492869
95MP0005584_abnormal_enzyme/coenzyme_acti0.60212786
96MP0004130_abnormal_muscle_cell0.55722372
97MP0002083_premature_death0.54560200
98MP0001905_abnormal_dopamine_level0.52667677
99MP0000249_abnormal_blood_vessel0.51524942
100MP0005165_increased_susceptibility_to0.49894534

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)7.56998335
2Granulocytopenia (HP:0001913)6.07119632
3Eosinophilia (HP:0001880)5.47844355
4Periodontitis (HP:0000704)5.44257594
5Abnormality of eosinophils (HP:0001879)4.66747312
6Agammaglobulinemia (HP:0004432)4.44475395
7Abnormality of the prostate (HP:0008775)4.23212334
8Obstructive lung disease (HP:0006536)4.17881361
9Chronic obstructive pulmonary disease (HP:0006510)4.17881361
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.14701802
11Meningitis (HP:0001287)4.03066217
12Chest pain (HP:0100749)3.86808546
13Panhypogammaglobulinemia (HP:0003139)3.84222568
14Leukocytosis (HP:0001974)3.75860238
153-Methylglutaconic aciduria (HP:0003535)3.58057071
16Elevated erythrocyte sedimentation rate (HP:0003565)3.54098542
17T lymphocytopenia (HP:0005403)3.49566361
18Abnormality of T cell number (HP:0011839)3.44035148
19Autoimmune hemolytic anemia (HP:0001890)3.37484833
20Abnormality of B cell number (HP:0010975)3.36872398
21Recurrent bacterial skin infections (HP:0005406)3.29907480
22Recurrent abscess formation (HP:0002722)3.29068139
23Hypergammaglobulinemia (HP:0010702)3.21917890
24Myositis (HP:0100614)3.21189111
25Hemoptysis (HP:0002105)3.17867036
26Bile duct proliferation (HP:0001408)3.11013414
27Abnormal biliary tract physiology (HP:0012439)3.11013414
28Chronic mucocutaneous candidiasis (HP:0002728)3.02976692
29Recurrent cutaneous fungal infections (HP:0011370)3.02976692
30Hypoproteinemia (HP:0003075)3.01898855
31Severe combined immunodeficiency (HP:0004430)2.98524263
32Abnormality of T cells (HP:0002843)2.97609554
33Ureteral stenosis (HP:0000071)2.95287975
34Gangrene (HP:0100758)2.81648956
35B lymphocytopenia (HP:0010976)2.79854744
36Pulmonary fibrosis (HP:0002206)2.73870869
37Pulmonary infiltrates (HP:0002113)2.64942573
38Recurrent fungal infections (HP:0002841)2.62594375
39Ureteral obstruction (HP:0006000)2.62333431
40Sepsis (HP:0100806)2.60734423
41Vasculitis (HP:0002633)2.59559014
42Abnormality of macrophages (HP:0004311)2.59520329
43Encephalitis (HP:0002383)2.57761384
44Recurrent skin infections (HP:0001581)2.55619155
45Abnormality of male internal genitalia (HP:0000022)2.53316386
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.52113640
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51644151
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51644151
49Epistaxis (HP:0000421)2.47684120
50Abnormality of midbrain morphology (HP:0002418)2.42893525
51Molar tooth sign on MRI (HP:0002419)2.42893525
52IgG deficiency (HP:0004315)2.41901623
53Combined immunodeficiency (HP:0005387)2.38905806
54Abnormality of T cell physiology (HP:0011840)2.36250904
55Dysostosis multiplex (HP:0000943)2.34326539
56Mitochondrial inheritance (HP:0001427)2.34110677
57Pulmonary embolism (HP:0002204)2.33953427
58Amaurosis fugax (HP:0100576)2.32764262
59Severe visual impairment (HP:0001141)2.29088091
60Autoimmune thrombocytopenia (HP:0001973)2.27182510
61Abnormality of the pleura (HP:0002103)2.26888893
62Neutropenia (HP:0001875)2.25790515
63Stomatitis (HP:0010280)2.23305845
64Skin rash (HP:0000988)2.19844175
65Neoplasm of the adrenal cortex (HP:0100641)2.17663343
66Recurrent viral infections (HP:0004429)2.16337152
67Thrombophlebitis (HP:0004418)2.15640628
68Hypertensive crisis (HP:0100735)2.14316345
69J-shaped sella turcica (HP:0002680)2.13763654
70Gastrointestinal infarctions (HP:0005244)2.13182136
71Increased cerebral lipofuscin (HP:0011813)2.11652765
72Mediastinal lymphadenopathy (HP:0100721)2.08164244
73Stomach cancer (HP:0012126)2.07575383
74Abnormality of the pericardium (HP:0001697)2.06358959
75Tetraplegia (HP:0002445)2.05071745
76Poor head control (HP:0002421)2.04570007
77Neurodegeneration (HP:0002180)2.04143208
78Type I transferrin isoform profile (HP:0003642)2.03932556
79Hemiplegia (HP:0002301)2.03764988
80Pustule (HP:0200039)2.03493679
81Acute lymphatic leukemia (HP:0006721)2.01306694
82Increased intramyocellular lipid droplets (HP:0012240)2.00169943
83Gingival bleeding (HP:0000225)1.98366438
84Aplasia/Hypoplasia of the thymus (HP:0010515)1.97547012
85Recurrent bronchitis (HP:0002837)1.96702310
86Acute necrotizing encephalopathy (HP:0006965)1.95173572
87Skin ulcer (HP:0200042)1.93982800
88Bifid tongue (HP:0010297)1.93850216
89Zonular cataract (HP:0010920)1.93295912
90Increased serum ferritin (HP:0003281)1.89872322
91Cellulitis (HP:0100658)1.89358147
92Hepatocellular necrosis (HP:0001404)1.87953986
93Thyroiditis (HP:0100646)1.86622372
94Albinism (HP:0001022)1.85845361
95Hepatosplenomegaly (HP:0001433)1.85159002
96Hypoplasia of the thymus (HP:0000778)1.82730827
97Gastrointestinal inflammation (HP:0004386)1.79301114
98Orchitis (HP:0100796)1.79271860
99Prolonged bleeding time (HP:0003010)1.79233194
100Eczematoid dermatitis (HP:0000976)1.79112808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.82124188
2TESK25.70115841
3ZAK3.54711179
4KDR3.47295283
5VRK22.79982125
6FES2.56530261
7MAP4K12.55294398
8BCKDK2.51338320
9TRIM282.47462854
10NUAK12.42353762
11PIK3CG2.39138629
12ERN12.34747212
13GRK72.25086005
14RIPK42.17682884
15ITK2.00897119
16TEC1.96696550
17MAP2K31.84575056
18PIM21.73170044
19BMPR21.63039742
20TAOK31.59541829
21SYK1.59298191
22JAK31.55587398
23ZAP701.55559759
24TBK11.55169110
25ADRBK21.47237673
26MAP2K61.40585895
27KIT1.36416859
28CDK121.35154246
29TNK21.30188674
30PIK3CA1.29887274
31LCK1.16380007
32ARAF1.15533129
33TGFBR21.09843667
34LYN1.09159704
35CDK61.08024829
36IKBKE1.07586733
37BTK1.07386318
38LATS11.06179065
39VRK11.02330299
40GRK60.99052200
41PRKCQ0.94615803
42IKBKB0.94366184
43PIM10.93781791
44CSF1R0.89939580
45BUB10.85630085
46MAPK40.85414547
47MAP3K60.81555897
48ABL20.74091743
49HCK0.72542765
50MAP3K140.70001029
51MAP3K50.69567613
52IRAK30.66351232
53CSK0.64081080
54MAPK150.63034359
55JAK20.61490391
56HIPK20.60272788
57PLK40.60160160
58CHEK20.59835329
59GSK3A0.58913440
60IRAK40.57550971
61MARK30.56968967
62STK160.55213662
63TLK10.55118645
64TIE10.50800537
65BLK0.48309505
66CDK40.48170308
67SCYL20.46129516
68MELK0.44432376
69PNCK0.44297230
70ATR0.42178280
71RAF10.41991221
72EIF2AK20.38927350
73RPS6KA50.37014720
74JAK10.36801430
75SRPK10.36576115
76ADRBK10.36001005
77FYN0.35852289
78TYK20.34361998
79LRRK20.30750615
80GRK50.30201191
81ABL10.30130253
82MAPK70.29609339
83FLT30.29440869
84GRK10.28657675
85PDK10.28625135
86DAPK10.28240284
87MAP2K20.26917326
88RET0.26700189
89MAP3K130.25831385
90CDC70.24983546
91MAP2K40.24982270
92TTK0.23946769
93MOS0.22284184
94MAPK30.22042988
95CAMK2D0.20979744
96TRPM70.20814767
97INSRR0.20429668
98IGF1R0.19851074
99RPS6KA40.18648911
100STK100.17579016

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.91810136
2Autoimmune thyroid disease_Homo sapiens_hsa053203.25844911
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.23667056
4Graft-versus-host disease_Homo sapiens_hsa053322.93293708
5Allograft rejection_Homo sapiens_hsa053302.89053894
6Rheumatoid arthritis_Homo sapiens_hsa053232.84503276
7Hematopoietic cell lineage_Homo sapiens_hsa046402.37553146
8Type I diabetes mellitus_Homo sapiens_hsa049402.25608976
9Ribosome_Homo sapiens_hsa030102.25361665
10Homologous recombination_Homo sapiens_hsa034402.13931325
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12829962
12Antigen processing and presentation_Homo sapiens_hsa046122.12341375
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11632886
14Asthma_Homo sapiens_hsa053102.09746050
15Salmonella infection_Homo sapiens_hsa051321.95157962
16T cell receptor signaling pathway_Homo sapiens_hsa046601.90159052
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.88244651
18Staphylococcus aureus infection_Homo sapiens_hsa051501.70088115
19Leishmaniasis_Homo sapiens_hsa051401.62877283
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.60357098
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56861531
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.52597262
23RNA polymerase_Homo sapiens_hsa030201.47065124
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.44645121
25Measles_Homo sapiens_hsa051621.42759830
26Oxidative phosphorylation_Homo sapiens_hsa001901.40767335
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39347512
28Renin-angiotensin system_Homo sapiens_hsa046141.36710016
29Systemic lupus erythematosus_Homo sapiens_hsa053221.36548718
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33351415
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31076705
32Osteoclast differentiation_Homo sapiens_hsa043801.30142768
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28549945
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28039285
35Parkinsons disease_Homo sapiens_hsa050121.27129410
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.24233785
37Chemokine signaling pathway_Homo sapiens_hsa040621.18296835
38Malaria_Homo sapiens_hsa051441.14813981
39DNA replication_Homo sapiens_hsa030301.10354017
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06056607
41Viral myocarditis_Homo sapiens_hsa054161.03729842
42Herpes simplex infection_Homo sapiens_hsa051680.98964731
43Proteasome_Homo sapiens_hsa030500.97373995
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97083497
45Other glycan degradation_Homo sapiens_hsa005110.91796853
46Peroxisome_Homo sapiens_hsa041460.87493122
47Tuberculosis_Homo sapiens_hsa051520.86525826
48B cell receptor signaling pathway_Homo sapiens_hsa046620.84292949
49Epstein-Barr virus infection_Homo sapiens_hsa051690.82936943
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80633751
51Influenza A_Homo sapiens_hsa051640.79200019
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79111253
53Butanoate metabolism_Homo sapiens_hsa006500.75642937
54Shigellosis_Homo sapiens_hsa051310.74527975
55Phagosome_Homo sapiens_hsa041450.73073097
56TNF signaling pathway_Homo sapiens_hsa046680.72904375
57Mismatch repair_Homo sapiens_hsa034300.71976204
58HTLV-I infection_Homo sapiens_hsa051660.71775002
59Base excision repair_Homo sapiens_hsa034100.71735806
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71439290
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70813154
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.69834717
63Fanconi anemia pathway_Homo sapiens_hsa034600.69803181
64Acute myeloid leukemia_Homo sapiens_hsa052210.68078989
65Alzheimers disease_Homo sapiens_hsa050100.66698669
66Pyrimidine metabolism_Homo sapiens_hsa002400.64152364
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62421994
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60511958
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59181785
70Platelet activation_Homo sapiens_hsa046110.58553830
71Purine metabolism_Homo sapiens_hsa002300.56922170
72Apoptosis_Homo sapiens_hsa042100.56348919
73Regulation of autophagy_Homo sapiens_hsa041400.53872991
74Huntingtons disease_Homo sapiens_hsa050160.51717643
75Legionellosis_Homo sapiens_hsa051340.51345449
76Spliceosome_Homo sapiens_hsa030400.47755195
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47238859
78Pertussis_Homo sapiens_hsa051330.46223955
79African trypanosomiasis_Homo sapiens_hsa051430.46197679
80Lysosome_Homo sapiens_hsa041420.45720837
81Caffeine metabolism_Homo sapiens_hsa002320.43300723
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40448210
83Amoebiasis_Homo sapiens_hsa051460.40141236
84Linoleic acid metabolism_Homo sapiens_hsa005910.40030425
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39941464
86Non-small cell lung cancer_Homo sapiens_hsa052230.39911445
87Nucleotide excision repair_Homo sapiens_hsa034200.39384463
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.38222511
89N-Glycan biosynthesis_Homo sapiens_hsa005100.37835930
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33545579
91VEGF signaling pathway_Homo sapiens_hsa043700.32990220
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.31304444
93Toxoplasmosis_Homo sapiens_hsa051450.30844465
94Fatty acid metabolism_Homo sapiens_hsa012120.30174908
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.30119736
96Cardiac muscle contraction_Homo sapiens_hsa042600.29708111
97Viral carcinogenesis_Homo sapiens_hsa052030.27536015
98Pancreatic cancer_Homo sapiens_hsa052120.27333934
99Pentose phosphate pathway_Homo sapiens_hsa000300.27237436
100Tryptophan metabolism_Homo sapiens_hsa003800.26119119

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