TRGV10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.85791131
2negative regulation of cell killing (GO:0031342)6.85791131
3cellular response to interleukin-15 (GO:0071350)6.68014684
4response to interleukin-15 (GO:0070672)6.43322775
5negative T cell selection (GO:0043383)6.40025355
6positive regulation of gamma-delta T cell activation (GO:0046645)6.15988422
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.14119023
8negative thymic T cell selection (GO:0045060)6.01651420
9activated T cell proliferation (GO:0050798)5.88884419
10positive regulation of natural killer cell mediated immunity (GO:0002717)5.80422927
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.73591182
12regulation of natural killer cell mediated immunity (GO:0002715)5.62720265
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.62720265
14positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.56765709
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.51415846
16regulation of gamma-delta T cell differentiation (GO:0045586)5.49025535
17positive thymic T cell selection (GO:0045059)5.48665001
18positive T cell selection (GO:0043368)5.39422323
19regulation of B cell receptor signaling pathway (GO:0050855)5.38113512
20thymic T cell selection (GO:0045061)5.08442688
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97080603
22cytidine deamination (GO:0009972)4.95443662
23cytidine metabolic process (GO:0046087)4.95443662
24cytidine catabolic process (GO:0006216)4.95443662
25positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.86631974
26regulation of gamma-delta T cell activation (GO:0046643)4.78890642
27regulation of leukocyte mediated cytotoxicity (GO:0001910)4.78780752
28T cell selection (GO:0045058)4.58113272
29antigen processing and presentation of endogenous antigen (GO:0019883)4.48329897
30pyrimidine ribonucleoside catabolic process (GO:0046133)4.45735761
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43134488
32T cell migration (GO:0072678)4.37986369
33positive regulation of cell killing (GO:0031343)4.35918420
34DNA deamination (GO:0045006)4.35155787
35regulation of cell killing (GO:0031341)4.31289100
36antigen processing and presentation via MHC class Ib (GO:0002475)4.22339063
37positive regulation of granulocyte differentiation (GO:0030854)4.14857000
38regulation of regulatory T cell differentiation (GO:0045589)4.05929755
39regulation of T cell mediated cytotoxicity (GO:0001914)4.00215786
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.94100069
41regulation of isotype switching to IgG isotypes (GO:0048302)3.92437430
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.81107237
43mast cell activation (GO:0045576)3.78223016
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.74682008
45T cell receptor signaling pathway (GO:0050852)3.74446491
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71206708
47negative regulation of T cell apoptotic process (GO:0070233)3.68713062
48interferon-gamma production (GO:0032609)3.68625099
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.67590268
50negative regulation of viral genome replication (GO:0045071)3.66722863
51leukocyte aggregation (GO:0070486)3.58683962
52tolerance induction (GO:0002507)3.56739954
53antigen receptor-mediated signaling pathway (GO:0050851)3.50325729
54positive regulation of T cell cytokine production (GO:0002726)3.46998154
55regulation of alpha-beta T cell proliferation (GO:0046640)3.46736860
56positive regulation of lymphocyte mediated immunity (GO:0002708)3.45121415
57regulation of T cell tolerance induction (GO:0002664)3.44166304
58regulation of T cell receptor signaling pathway (GO:0050856)3.43709474
59mast cell activation involved in immune response (GO:0002279)3.43257510
60mast cell degranulation (GO:0043303)3.43257510
61dendritic cell chemotaxis (GO:0002407)3.43017193
62negative regulation of T cell mediated immunity (GO:0002710)3.41409710
63cellular defense response (GO:0006968)3.40564932
64positive regulation of tolerance induction (GO:0002645)3.40452722
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38227989
66natural killer cell activation (GO:0030101)3.36102233
67alpha-beta T cell differentiation (GO:0046632)3.35618385
68negative regulation of leukocyte mediated immunity (GO:0002704)3.34796930
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34576626
70T cell costimulation (GO:0031295)3.31230700
71positive regulation of T cell mediated immunity (GO:0002711)3.28348831
72lymphocyte costimulation (GO:0031294)3.27635195
73positive regulation of calcium-mediated signaling (GO:0050850)3.25587824
74regulation of lymphocyte mediated immunity (GO:0002706)3.24234526
75mucosal-associated lymphoid tissue development (GO:0048537)3.21200838
76Peyers patch development (GO:0048541)3.21200838
77T-helper cell differentiation (GO:0042093)3.20834661
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20834661
79regulation of B cell differentiation (GO:0045577)3.20151525
80T cell differentiation (GO:0030217)3.18831985
81type I interferon signaling pathway (GO:0060337)3.13983225
82cellular response to type I interferon (GO:0071357)3.13983225
83response to interferon-beta (GO:0035456)3.13120418
84positive regulation of macrophage differentiation (GO:0045651)3.11123749
85alpha-beta T cell activation (GO:0046631)3.10478343
86actin nucleation (GO:0045010)3.10302819
87dendritic cell migration (GO:0036336)3.10184551
88response to type I interferon (GO:0034340)3.09783561
89regulation of T cell mediated immunity (GO:0002709)3.08021861
90positive regulation of leukocyte mediated immunity (GO:0002705)3.07934979
91alpha-beta T cell activation involved in immune response (GO:0002287)3.05770113
92T cell differentiation involved in immune response (GO:0002292)3.05770113
93alpha-beta T cell differentiation involved in immune response (GO:0002293)3.05770113
94negative regulation of innate immune response (GO:0045824)3.04418055
95regulation of tolerance induction (GO:0002643)3.03668926
96positive regulation of translational initiation (GO:0045948)3.02476426
97B cell receptor signaling pathway (GO:0050853)2.98584441
98negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.98338686
99positive regulation of mRNA catabolic process (GO:0061014)2.98092727
100positive regulation of B cell differentiation (GO:0045579)2.96523206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.57949457
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.13538838
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.38950442
4RUNX_20019798_ChIP-Seq_JUKART_Human4.71235377
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28365352
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.91197019
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.83118472
8MYB_26560356_Chip-Seq_TH2_Human3.80478261
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23995723
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.15493956
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.09588100
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99444168
13GATA3_27048872_Chip-Seq_THYMUS_Human2.85790512
14UTX_26944678_Chip-Seq_JUKART_Human2.81263630
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76614843
16MYB_26560356_Chip-Seq_TH1_Human2.75127298
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69046682
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.53222225
19MAF_26560356_Chip-Seq_TH1_Human2.52698121
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35777426
21GATA3_26560356_Chip-Seq_TH2_Human2.35349927
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19767891
23MAF_26560356_Chip-Seq_TH2_Human2.13229375
24SPI1_23547873_ChIP-Seq_NB4_Human2.07395772
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00070734
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97751437
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.97743902
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97333597
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.77163037
30MYC_22102868_ChIP-Seq_BL_Human1.76413690
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.75824553
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70286275
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69658384
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67261148
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.67046158
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66164873
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.63550802
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62512313
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62420966
40SCL_19346495_ChIP-Seq_HPC-7_Human1.61272569
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56240214
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54556995
43GATA1_22025678_ChIP-Seq_K562_Human1.50976349
44SPI1_23127762_ChIP-Seq_K562_Human1.46222438
45VDR_24763502_ChIP-Seq_THP-1_Human1.44500986
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41714272
47VDR_23849224_ChIP-Seq_CD4+_Human1.31536343
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.27083718
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24441011
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21979121
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21189043
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16893026
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16641517
54VDR_21846776_ChIP-Seq_THP-1_Human1.16571579
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11879445
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11273086
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07673518
58GATA3_26560356_Chip-Seq_TH1_Human1.04970155
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03878343
60RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02343692
61CIITA_25753668_ChIP-Seq_RAJI_Human1.02311554
62GATA1_19941827_ChIP-Seq_MEL_Mouse0.99903516
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97689603
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97057234
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96422501
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96271976
67BCL6_27268052_Chip-Seq_Bcells_Human0.95733639
68NFE2_27457419_Chip-Seq_LIVER_Mouse0.95536052
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93892594
70FOXP3_21729870_ChIP-Seq_TREG_Human0.91570714
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90957237
72PU_27001747_Chip-Seq_BMDM_Mouse0.90796799
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88968605
74SMRT_27268052_Chip-Seq_Bcells_Human0.88916408
75ELF1_20517297_ChIP-Seq_JURKAT_Human0.87846024
76TCF7_22412390_ChIP-Seq_EML_Mouse0.87765845
77IRF1_19129219_ChIP-ChIP_H3396_Human0.87015025
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87005699
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86843066
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86499530
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85868750
82VDR_24787735_ChIP-Seq_THP-1_Human0.85527918
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85180192
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84889772
85SPI1_20517297_ChIP-Seq_HL60_Human0.84773873
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84113782
87KDM2B_26808549_Chip-Seq_DND41_Human0.83425235
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.81800018
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81076443
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79566086
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77619172
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76171730
93NANOG_20526341_ChIP-Seq_ESCs_Human0.75332969
94P300_27268052_Chip-Seq_Bcells_Human0.75193283
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74646017
96BCOR_27268052_Chip-Seq_Bcells_Human0.74163654
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73696427
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73373948
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73373100
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72706926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.55202213
2MP0003763_abnormal_thymus_physiology4.87338825
3MP0001835_abnormal_antigen_presentation3.95510455
4MP0000685_abnormal_immune_system3.36805198
5MP0005000_abnormal_immune_tolerance3.35764272
6MP0009785_altered_susceptibility_to3.32288395
7MP0001800_abnormal_humoral_immune3.27321900
8MP0003436_decreased_susceptibility_to3.23727117
9MP0003724_increased_susceptibility_to3.14136289
10MP0002723_abnormal_immune_serum2.97944376
11MP0002420_abnormal_adaptive_immunity2.89110981
12MP0005025_abnormal_response_to2.87939961
13MP0001819_abnormal_immune_cell2.84421957
14MP0009333_abnormal_splenocyte_physiolog2.74246390
15MP0002166_altered_tumor_susceptibility2.66646765
16MP0001790_abnormal_immune_system2.65579670
17MP0005387_immune_system_phenotype2.65579670
18MP0002452_abnormal_antigen_presenting2.58577250
19MP0002398_abnormal_bone_marrow2.46498286
20MP0002419_abnormal_innate_immunity2.43216480
21MP0000703_abnormal_thymus_morphology2.37789705
22MP0002405_respiratory_system_inflammati2.34530454
23MP0002148_abnormal_hypersensitivity_rea2.30660786
24MP0000716_abnormal_immune_system2.27177239
25MP0004381_abnormal_hair_follicle2.23533338
26MP0010155_abnormal_intestine_physiology2.10772831
27MP0002722_abnormal_immune_system2.04714040
28MP0004947_skin_inflammation2.03096280
29MP0000689_abnormal_spleen_morphology2.01084937
30MP0001845_abnormal_inflammatory_respons1.97341712
31MP0003866_abnormal_defecation1.97310264
32MP0002006_tumorigenesis1.96519003
33MP0006082_CNS_inflammation1.92425447
34MP0005075_abnormal_melanosome_morpholog1.86777986
35MP0002009_preneoplasia1.80648477
36MP0002429_abnormal_blood_cell1.77636268
37MP0005464_abnormal_platelet_physiology1.71123741
38MP0002933_joint_inflammation1.47788983
39MP0002396_abnormal_hematopoietic_system1.47461283
40MP0001533_abnormal_skeleton_physiology1.46066597
41MP0000858_altered_metastatic_potential1.42614523
42MP0008469_abnormal_protein_level1.38804475
43MP0004130_abnormal_muscle_cell1.34886045
44MP0009764_decreased_sensitivity_to1.27432436
45MP0005310_abnormal_salivary_gland1.26923575
46MP0001873_stomach_inflammation1.23370948
47MP0003300_gastrointestinal_ulcer1.22344111
48MP0001853_heart_inflammation1.19403978
49MP0008877_abnormal_DNA_methylation1.08714704
50MP0000015_abnormal_ear_pigmentation1.07069653
51MP0001986_abnormal_taste_sensitivity1.02724924
52MP0009763_increased_sensitivity_to0.99934489
53MP0000465_gastrointestinal_hemorrhage0.99733270
54MP0001851_eye_inflammation0.96238465
55MP0005174_abnormal_tail_pigmentation0.92487062
56MP0003787_abnormal_imprinting0.91040705
57MP0005377_hearing/vestibular/ear_phenot0.88349683
58MP0003878_abnormal_ear_physiology0.88349683
59MP0002163_abnormal_gland_morphology0.86645647
60MP0006072_abnormal_retinal_apoptosis0.83957999
61MP0002019_abnormal_tumor_incidence0.83255687
62MP0001348_abnormal_lacrimal_gland0.81990506
63MP0003448_altered_tumor_morphology0.80348447
64MP0001919_abnormal_reproductive_system0.80192059
65MP0000372_irregular_coat_pigmentation0.79272448
66MP0002998_abnormal_bone_remodeling0.73195935
67MP0000490_abnormal_crypts_of0.73084417
68MP0005451_abnormal_body_composition0.71418551
69MP0000569_abnormal_digit_pigmentation0.68814720
70MP0003252_abnormal_bile_duct0.68607350
71MP0002693_abnormal_pancreas_physiology0.66448132
72MP0001765_abnormal_ion_homeostasis0.65250978
73MP0004742_abnormal_vestibular_system0.61445940
74MP0009765_abnormal_xenobiotic_induced0.61314990
75MP0003828_pulmonary_edema0.61288167
76MP0003045_fibrosis0.60847244
77MP0002638_abnormal_pupillary_reflex0.58624521
78MP0002132_abnormal_respiratory_system0.56774843
79MP0005390_skeleton_phenotype0.56686760
80MP0005166_decreased_susceptibility_to0.56338518
81MP0003303_peritoneal_inflammation0.55229926
82MP0001243_abnormal_dermal_layer0.49957289
83MP0008961_abnormal_basal_metabolism0.48679170
84MP0003172_abnormal_lysosome_physiology0.47612404
85MP0008873_increased_physiological_sensi0.47241192
86MP0004264_abnormal_extraembryonic_tissu0.47213654
87MP0002876_abnormal_thyroid_physiology0.46595509
88MP0004134_abnormal_chest_morphology0.46271761
89MP0004885_abnormal_endolymph0.46252177
90MP0003638_abnormal_response/metabolism_0.45819550
91MP0008057_abnormal_DNA_replication0.45190342
92MP0000249_abnormal_blood_vessel0.44652041
93MP0002138_abnormal_hepatobiliary_system0.42791419
94MP0003786_premature_aging0.42711184
95MP0004185_abnormal_adipocyte_glucose0.41821211
96MP0002095_abnormal_skin_pigmentation0.40120102
97MP0002136_abnormal_kidney_physiology0.40016562
98MP0000609_abnormal_liver_physiology0.38904553
99MP0009642_abnormal_blood_homeostasis0.38791684
100MP0000477_abnormal_intestine_morphology0.38644290

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.71257797
2Abnormality of T cell number (HP:0011839)6.67180726
3IgG deficiency (HP:0004315)6.13950511
4Increased IgM level (HP:0003496)6.09471203
5Myositis (HP:0100614)4.95417901
6Abnormality of T cells (HP:0002843)4.88493618
7Retrobulbar optic neuritis (HP:0100654)4.85902344
8Optic neuritis (HP:0100653)4.85902344
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.82928289
10Severe combined immunodeficiency (HP:0004430)4.81966494
11Abnormality of eosinophils (HP:0001879)4.62181407
12Eosinophilia (HP:0001880)4.54063022
13Elevated erythrocyte sedimentation rate (HP:0003565)4.47724756
14Orchitis (HP:0100796)4.39608256
15Granulocytopenia (HP:0001913)4.35044572
16Encephalitis (HP:0002383)4.30905187
17Autoimmune hemolytic anemia (HP:0001890)4.14963109
18Stomatitis (HP:0010280)4.12620756
19Recurrent fungal infections (HP:0002841)3.90722717
20Leukocytosis (HP:0001974)3.86047143
21Abnormality of B cell number (HP:0010975)3.81640982
22Combined immunodeficiency (HP:0005387)3.80050084
23Meningitis (HP:0001287)3.72010692
24Vasculitis (HP:0002633)3.70524939
25Joint swelling (HP:0001386)3.66673687
26Pustule (HP:0200039)3.62457805
27Eczematoid dermatitis (HP:0000976)3.60264957
28Autoimmune thrombocytopenia (HP:0001973)3.58157351
29Panhypogammaglobulinemia (HP:0003139)3.57284181
30Abnormality of T cell physiology (HP:0011840)3.52366322
31Hypoproteinemia (HP:0003075)3.49383110
32Chronic mucocutaneous candidiasis (HP:0002728)3.46797392
33Recurrent cutaneous fungal infections (HP:0011370)3.46797392
34Pulmonary infiltrates (HP:0002113)3.45910045
35Chronic diarrhea (HP:0002028)3.39487872
36Keratoconjunctivitis sicca (HP:0001097)3.37263496
37Keratoconjunctivitis (HP:0001096)3.29921969
38Hypergammaglobulinemia (HP:0010702)3.26997637
39Recurrent viral infections (HP:0004429)3.26526960
40Thyroiditis (HP:0100646)3.24679891
41Abnormality of cells of the lymphoid lineage (HP:0012140)3.15749853
42Hemoptysis (HP:0002105)3.15508017
43Recurrent bronchitis (HP:0002837)3.14067756
44Lymphopenia (HP:0001888)3.11522497
45B lymphocytopenia (HP:0010976)3.08292904
46Hypoplasia of the thymus (HP:0000778)2.86879989
47Agammaglobulinemia (HP:0004432)2.86254287
48Gastrointestinal infarctions (HP:0005244)2.76300700
49Stomach cancer (HP:0012126)2.76232128
50Recurrent bacterial skin infections (HP:0005406)2.75294487
51Mediastinal lymphadenopathy (HP:0100721)2.71649843
52IgM deficiency (HP:0002850)2.71053514
53Gangrene (HP:0100758)2.67125027
54Arterial thrombosis (HP:0004420)2.66820821
55Recurrent abscess formation (HP:0002722)2.66106660
56Increased IgE level (HP:0003212)2.56153989
57Recurrent skin infections (HP:0001581)2.53146462
58Abnormality of the pleura (HP:0002103)2.45833477
59Lymphoma (HP:0002665)2.44267918
60Hemiplegia (HP:0002301)2.44029647
61Obstructive lung disease (HP:0006536)2.43051664
62Chronic obstructive pulmonary disease (HP:0006510)2.43051664
63IgA deficiency (HP:0002720)2.42752964
64Pulmonary embolism (HP:0002204)2.40643497
65Abnormality of macrophages (HP:0004311)2.37177496
66Keratitis (HP:0000491)2.36690379
67Spontaneous hematomas (HP:0007420)2.36164335
68Anorexia (HP:0002039)2.34889026
69Chest pain (HP:0100749)2.34298807
70Abnormality of the prostate (HP:0008775)2.30600197
71Glomerulopathy (HP:0100820)2.30294250
72Acute hepatic failure (HP:0006554)2.28840360
73Verrucae (HP:0200043)2.25286415
74Papilloma (HP:0012740)2.25286415
75Hypochromic anemia (HP:0001931)2.22899711
76Prolonged bleeding time (HP:0003010)2.14719238
77Polyneuropathy (HP:0001271)2.10272209
78Bronchitis (HP:0012387)2.02484485
79Inflammation of the large intestine (HP:0002037)1.95195998
80Epistaxis (HP:0000421)1.94456709
81Gingival bleeding (HP:0000225)1.90948019
82Pulmonary fibrosis (HP:0002206)1.90872205
83Abnormality of the endocardium (HP:0004306)1.89542484
84Neutropenia (HP:0001875)1.86729080
85Vertigo (HP:0002321)1.85422416
86Increased serum ferritin (HP:0003281)1.84949684
87Recurrent gram-negative bacterial infections (HP:0005420)1.82535344
88Gastrointestinal inflammation (HP:0004386)1.81171772
89Papilledema (HP:0001085)1.76001051
90Skin rash (HP:0000988)1.74952777
91Fatigue (HP:0012378)1.73821069
923-Methylglutaconic aciduria (HP:0003535)1.68735911
93Arthralgia (HP:0002829)1.67968401
94Urticaria (HP:0001025)1.67701265
95Abnormality of iron homeostasis (HP:0011031)1.65400229
96Gastrointestinal stroma tumor (HP:0100723)1.64521161
97Acne (HP:0001061)1.62418962
98Anhidrosis (HP:0000970)1.61631401
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.59338073
100Abnormality of transition element cation homeostasis (HP:0011030)1.56951229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.86270075
2TXK5.51073931
3MAP4K13.96131016
4GRK63.37761653
5MAP3K142.77684365
6FES2.71544041
7TESK22.41376708
8KDR2.22288576
9TNK22.17141123
10JAK12.08700683
11TLK12.07530494
12ZAP702.01824630
13ITK1.95729839
14ZAK1.94264482
15CSK1.91982254
16PRPF4B1.87772995
17JAK31.83872288
18IKBKE1.80946125
19VRK11.80810607
20BTK1.77613741
21RIPK11.68615057
22SYK1.65136956
23TBK11.63320494
24LCK1.52609849
25MAP2K21.52322011
26TYK21.45702587
27RIPK41.45621492
28MST41.44402580
29TYRO31.42256160
30SIK21.31854770
31SIK31.31050942
32MAP2K61.28302043
33PRKCQ1.25452136
34TRIM281.25383690
35LYN1.21518908
36TEC1.15386127
37IRAK31.14652873
38NLK1.14216688
39IKBKB1.11426403
40HCK1.09185289
41BLK1.01694132
42NUAK11.00909013
43TRPM70.99914345
44ADRBK20.97457689
45CAMKK10.95691927
46CAMKK20.90505804
47PIM10.89480878
48STK100.86259058
49BCKDK0.85203981
50MAPK70.84711478
51KIT0.83856028
52MAP3K120.83086946
53MAPK110.81368568
54PIK3CA0.80158582
55PIK3CG0.80028901
56FGFR40.79919279
57MAP3K130.72854907
58CDK40.71657708
59GRK70.70002963
60TGFBR20.68538259
61BRD40.67992393
62IRAK40.67210836
63CLK10.65415269
64JAK20.62645716
65MATK0.56236408
66FGFR30.54206381
67PDGFRB0.53284261
68PDK10.51060140
69CDK80.49818398
70MARK30.46283235
71FYN0.46172394
72CSF1R0.44980987
73BCR0.44329261
74BMPR20.42552963
75MAPKAPK20.42260937
76MAP3K110.40890594
77MAPK120.39660158
78IGF1R0.39511262
79HIPK20.37177498
80INSR0.31061021
81LRRK20.24864700
82EIF2AK20.23407528
83MAPK30.23293656
84MAP3K100.22787373
85MAP3K10.21376868
86ACVR1B0.21266332
87NTRK20.18549772
88CHUK0.18385550
89BUB10.17719917
90MELK0.17708978
91RPS6KA50.17423070
92MAP4K20.17409645
93RET0.17035898
94TESK10.15431219
95WNK40.15308520
96EGFR0.14738574
97FGR0.14296497
98CDK60.13921316
99PRKCH0.13046378
100NEK60.12282556

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.48236898
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.10444486
3Graft-versus-host disease_Homo sapiens_hsa053323.83381202
4T cell receptor signaling pathway_Homo sapiens_hsa046603.47558409
5Antigen processing and presentation_Homo sapiens_hsa046123.04227958
6Hematopoietic cell lineage_Homo sapiens_hsa046402.88505876
7Autoimmune thyroid disease_Homo sapiens_hsa053202.79632946
8Allograft rejection_Homo sapiens_hsa053302.78626357
9Measles_Homo sapiens_hsa051622.53888353
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38989969
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35631392
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.16778754
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.13684182
14B cell receptor signaling pathway_Homo sapiens_hsa046622.03221660
15Type I diabetes mellitus_Homo sapiens_hsa049401.84526296
16Malaria_Homo sapiens_hsa051441.82966609
17Osteoclast differentiation_Homo sapiens_hsa043801.79231813
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73426716
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.73358197
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.66096402
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65764285
22Leishmaniasis_Homo sapiens_hsa051401.59835056
23Viral myocarditis_Homo sapiens_hsa054161.59531993
24TNF signaling pathway_Homo sapiens_hsa046681.58686018
25Asthma_Homo sapiens_hsa053101.52071821
26Chemokine signaling pathway_Homo sapiens_hsa040621.39965671
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38280016
28Acute myeloid leukemia_Homo sapiens_hsa052211.37067152
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36909245
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35377682
31Hepatitis B_Homo sapiens_hsa051611.34942159
32Apoptosis_Homo sapiens_hsa042101.30980241
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25040805
34Herpes simplex infection_Homo sapiens_hsa051681.23508276
35Staphylococcus aureus infection_Homo sapiens_hsa051501.17610110
36Shigellosis_Homo sapiens_hsa051311.11097117
37Epstein-Barr virus infection_Homo sapiens_hsa051691.04458562
38Influenza A_Homo sapiens_hsa051640.99868804
39Non-small cell lung cancer_Homo sapiens_hsa052230.92788440
40Legionellosis_Homo sapiens_hsa051340.86115544
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86038239
42Rheumatoid arthritis_Homo sapiens_hsa053230.85965249
43HTLV-I infection_Homo sapiens_hsa051660.85502263
44Tuberculosis_Homo sapiens_hsa051520.84930387
45Dorso-ventral axis formation_Homo sapiens_hsa043200.82591286
46Platelet activation_Homo sapiens_hsa046110.78041923
47Proteasome_Homo sapiens_hsa030500.76827606
48Toxoplasmosis_Homo sapiens_hsa051450.75637647
49Viral carcinogenesis_Homo sapiens_hsa052030.68724409
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66261578
51Chronic myeloid leukemia_Homo sapiens_hsa052200.65197575
52Hepatitis C_Homo sapiens_hsa051600.64176342
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63485146
54Salmonella infection_Homo sapiens_hsa051320.61863822
55Pertussis_Homo sapiens_hsa051330.58998124
56Pancreatic cancer_Homo sapiens_hsa052120.58365394
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.56724969
58African trypanosomiasis_Homo sapiens_hsa051430.55749344
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49129221
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44816975
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.43308486
62Prolactin signaling pathway_Homo sapiens_hsa049170.41356078
63Colorectal cancer_Homo sapiens_hsa052100.40740317
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.40269702
65Nitrogen metabolism_Homo sapiens_hsa009100.38361808
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37962579
67Endocytosis_Homo sapiens_hsa041440.36825589
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34193866
69Linoleic acid metabolism_Homo sapiens_hsa005910.33286477
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32400462
71MAPK signaling pathway_Homo sapiens_hsa040100.31908591
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.28777568
73Prion diseases_Homo sapiens_hsa050200.28675184
74VEGF signaling pathway_Homo sapiens_hsa043700.27329828
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26542270
76RNA polymerase_Homo sapiens_hsa030200.26505566
77Caffeine metabolism_Homo sapiens_hsa002320.26089989
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25403267
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25385441
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24131723
81Prostate cancer_Homo sapiens_hsa052150.23810770
82Homologous recombination_Homo sapiens_hsa034400.23321524
83Thyroid cancer_Homo sapiens_hsa052160.22477268
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22211870
85Fanconi anemia pathway_Homo sapiens_hsa034600.19582408
86Basal transcription factors_Homo sapiens_hsa030220.16928453
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16476764
88Phototransduction_Homo sapiens_hsa047440.15369401
89Glioma_Homo sapiens_hsa052140.13676766
90Inositol phosphate metabolism_Homo sapiens_hsa005620.12778761
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12531013
92Regulation of autophagy_Homo sapiens_hsa041400.10346969
93Amphetamine addiction_Homo sapiens_hsa050310.09113432
94Insulin resistance_Homo sapiens_hsa049310.08876096
95Endometrial cancer_Homo sapiens_hsa052130.08545926
96Choline metabolism in cancer_Homo sapiens_hsa052310.08459923
97Ras signaling pathway_Homo sapiens_hsa040140.07394809
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07176152
99Oxytocin signaling pathway_Homo sapiens_hsa049210.06781304
100Nucleotide excision repair_Homo sapiens_hsa034200.06747527

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