

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive T cell selection (GO:0043368) | 7.96625189 |
| 2 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 7.64348089 |
| 3 | negative T cell selection (GO:0043383) | 7.58689823 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.02203645 |
| 5 | positive thymic T cell selection (GO:0045059) | 6.78796966 |
| 6 | cellular response to interleukin-15 (GO:0071350) | 6.55115118 |
| 7 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.41229335 |
| 8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.37079479 |
| 9 | T cell receptor signaling pathway (GO:0050852) | 6.27180629 |
| 10 | negative thymic T cell selection (GO:0045060) | 6.23553178 |
| 11 | thymic T cell selection (GO:0045061) | 6.01257827 |
| 12 | T cell selection (GO:0045058) | 5.97883577 |
| 13 | response to interleukin-15 (GO:0070672) | 5.95706775 |
| 14 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.81636951 |
| 15 | negative regulation of cell killing (GO:0031342) | 5.81636951 |
| 16 | leukocyte aggregation (GO:0070486) | 5.74650463 |
| 17 | regulation of gamma-delta T cell activation (GO:0046643) | 5.70416217 |
| 18 | V(D)J recombination (GO:0033151) | 5.65145511 |
| 19 | T cell costimulation (GO:0031295) | 5.57016325 |
| 20 | lymphocyte costimulation (GO:0031294) | 5.54508260 |
| 21 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.49074993 |
| 22 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.49074993 |
| 23 | antigen receptor-mediated signaling pathway (GO:0050851) | 5.32150874 |
| 24 | antigen processing and presentation via MHC class Ib (GO:0002475) | 5.31076919 |
| 25 | ribosomal small subunit assembly (GO:0000028) | 4.73979807 |
| 26 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.61419060 |
| 27 | activated T cell proliferation (GO:0050798) | 4.49307093 |
| 28 | mast cell activation (GO:0045576) | 4.47566343 |
| 29 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.43977030 |
| 30 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.41790515 |
| 31 | Peyers patch development (GO:0048541) | 4.38352168 |
| 32 | mucosal-associated lymphoid tissue development (GO:0048537) | 4.38352168 |
| 33 | cytidine deamination (GO:0009972) | 4.32587274 |
| 34 | cytidine metabolic process (GO:0046087) | 4.32587274 |
| 35 | cytidine catabolic process (GO:0006216) | 4.32587274 |
| 36 | sequestering of actin monomers (GO:0042989) | 4.28880476 |
| 37 | T cell migration (GO:0072678) | 4.19561738 |
| 38 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.19359238 |
| 39 | regulation of T cell tolerance induction (GO:0002664) | 4.14604963 |
| 40 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 4.12902382 |
| 41 | negative regulation of T cell mediated immunity (GO:0002710) | 4.10192642 |
| 42 | B cell receptor signaling pathway (GO:0050853) | 4.05913662 |
| 43 | establishment of viral latency (GO:0019043) | 4.05158323 |
| 44 | positive regulation of B cell differentiation (GO:0045579) | 3.98963399 |
| 45 | positive regulation of lamellipodium assembly (GO:0010592) | 3.97557452 |
| 46 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.96386441 |
| 47 | tolerance induction (GO:0002507) | 3.93711389 |
| 48 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.90724918 |
| 49 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.83957530 |
| 50 | establishment of integrated proviral latency (GO:0075713) | 3.83196032 |
| 51 | cellular hyperosmotic response (GO:0071474) | 3.79939260 |
| 52 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.79556340 |
| 53 | T cell differentiation (GO:0030217) | 3.76634108 |
| 54 | somatic cell DNA recombination (GO:0016444) | 3.76098520 |
| 55 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 3.76098520 |
| 56 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.72855153 |
| 57 | positive regulation of macrophage differentiation (GO:0045651) | 3.72429897 |
| 58 | viral transcription (GO:0019083) | 3.69962203 |
| 59 | mast cell activation involved in immune response (GO:0002279) | 3.69478916 |
| 60 | mast cell degranulation (GO:0043303) | 3.69478916 |
| 61 | negative regulation of T cell apoptotic process (GO:0070233) | 3.68580767 |
| 62 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.66423022 |
| 63 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.64896942 |
| 64 | signal complex assembly (GO:0007172) | 3.64725433 |
| 65 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.58325833 |
| 66 | translational termination (GO:0006415) | 3.54930260 |
| 67 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.53023975 |
| 68 | T cell activation (GO:0042110) | 3.52378230 |
| 69 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.52151199 |
| 70 | detection of other organism (GO:0098543) | 3.50814412 |
| 71 | actin nucleation (GO:0045010) | 3.45454549 |
| 72 | detection of bacterium (GO:0016045) | 3.42827346 |
| 73 | somatic diversification of immune receptors (GO:0002200) | 3.42002040 |
| 74 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.41663144 |
| 75 | natural killer cell differentiation (GO:0001779) | 3.41624829 |
| 76 | regulation of response to interferon-gamma (GO:0060330) | 3.41415717 |
| 77 | ribosomal small subunit biogenesis (GO:0042274) | 3.41393505 |
| 78 | interferon-gamma production (GO:0032609) | 3.41313334 |
| 79 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.40631900 |
| 80 | regulation of granulocyte differentiation (GO:0030852) | 3.40095157 |
| 81 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.39270669 |
| 82 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.38045530 |
| 83 | DNA deamination (GO:0045006) | 3.37226849 |
| 84 | positive regulation of tolerance induction (GO:0002645) | 3.36990088 |
| 85 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.34842796 |
| 86 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.34842796 |
| 87 | DNA unwinding involved in DNA replication (GO:0006268) | 3.33297919 |
| 88 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.31948317 |
| 89 | regulation of tolerance induction (GO:0002643) | 3.31716495 |
| 90 | positive regulation by symbiont of host defense response (GO:0052509) | 3.28822676 |
| 91 | modulation by symbiont of host defense response (GO:0052031) | 3.28822676 |
| 92 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.28822676 |
| 93 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.28822676 |
| 94 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.28822676 |
| 95 | modulation by symbiont of host immune response (GO:0052553) | 3.28822676 |
| 96 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.27046203 |
| 97 | cellular extravasation (GO:0045123) | 3.26762695 |
| 98 | respiratory burst (GO:0045730) | 3.23916394 |
| 99 | positive regulation of astrocyte differentiation (GO:0048711) | 3.22781499 |
| 100 | negative regulation of interleukin-12 production (GO:0032695) | 3.21500176 |
| 101 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.21252060 |
| 102 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.21252060 |
| 103 | cellular response to interleukin-4 (GO:0071353) | 3.19101130 |
| 104 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.18850833 |
| 105 | T-helper cell differentiation (GO:0042093) | 3.18850833 |
| 106 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.16852703 |
| 107 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.16143244 |
| 108 | positive regulation of lamellipodium organization (GO:1902745) | 3.15867573 |
| 109 | regulation of necroptotic process (GO:0060544) | 3.14869866 |
| 110 | positive regulation of T cell activation (GO:0050870) | 3.13066768 |
| 111 | T cell differentiation in thymus (GO:0033077) | 3.08459057 |
| 112 | regulation of cell killing (GO:0031341) | 3.08298576 |
| 113 | positive regulation of granulocyte differentiation (GO:0030854) | 3.07249094 |
| 114 | translational elongation (GO:0006414) | 3.07138195 |
| 115 | natural killer cell activation (GO:0030101) | 3.05124296 |
| 116 | regulation of respiratory burst (GO:0060263) | 3.04234426 |
| 117 | leukocyte cell-cell adhesion (GO:0007159) | 3.04201966 |
| 118 | leukocyte degranulation (GO:0043299) | 3.04154131 |
| 119 | T cell homeostasis (GO:0043029) | 3.00724322 |
| 120 | regulation of regulatory T cell differentiation (GO:0045589) | 2.99856528 |
| 121 | myeloid cell activation involved in immune response (GO:0002275) | 2.99204233 |
| 122 | T cell differentiation involved in immune response (GO:0002292) | 2.98749175 |
| 123 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 2.98749175 |
| 124 | alpha-beta T cell activation involved in immune response (GO:0002287) | 2.98749175 |
| 125 | positive regulation of calcium-mediated signaling (GO:0050850) | 2.98427040 |
| 126 | negative regulation of viral genome replication (GO:0045071) | 2.96789655 |
| 127 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.95382017 |
| 128 | mitotic chromosome condensation (GO:0007076) | 2.92554520 |
| 129 | negative regulation of necroptotic process (GO:0060546) | 2.91925193 |
| 130 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.91872199 |
| 131 | regulation of B cell differentiation (GO:0045577) | 2.88785422 |
| 132 | hepatocyte apoptotic process (GO:0097284) | 2.88566517 |
| 133 | regulation of T cell activation (GO:0050863) | 2.86942425 |
| 134 | response to interleukin-4 (GO:0070670) | 2.86166761 |
| 135 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.86047891 |
| 136 | positive regulation of cell killing (GO:0031343) | 2.85962442 |
| 137 | alpha-beta T cell differentiation (GO:0046632) | 2.85485626 |
| 138 | cotranslational protein targeting to membrane (GO:0006613) | 2.85421957 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.11339380 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.30765911 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 5.14195472 |
| 4 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.47544587 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 3.34096917 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.31572614 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.17160845 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.08424344 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.00757938 |
| 10 | MYB_26560356_Chip-Seq_TH2_Human | 2.98294691 |
| 11 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.96296210 |
| 12 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.95742370 |
| 13 | UTX_26944678_Chip-Seq_JUKART_Human | 2.83217742 |
| 14 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.79608194 |
| 15 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.74755288 |
| 16 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.74395645 |
| 17 | MAF_26560356_Chip-Seq_TH1_Human | 2.66250487 |
| 18 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.58413416 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.55741480 |
| 20 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.48045590 |
| 21 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.47206640 |
| 22 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.42291961 |
| 23 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.35354717 |
| 24 | MYB_26560356_Chip-Seq_TH1_Human | 2.35312769 |
| 25 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.34205043 |
| 26 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.31354448 |
| 27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.24740876 |
| 28 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.22615089 |
| 29 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.97983702 |
| 30 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.94231309 |
| 31 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.93510931 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.91521036 |
| 33 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.87590056 |
| 34 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.87145145 |
| 35 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.85843034 |
| 36 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.84428797 |
| 37 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.81900350 |
| 38 | MAF_26560356_Chip-Seq_TH2_Human | 1.78445766 |
| 39 | GATA1_22025678_ChIP-Seq_K562_Human | 1.72997644 |
| 40 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.68973124 |
| 41 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.64425070 |
| 42 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.62751613 |
| 43 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.59630539 |
| 44 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.59409940 |
| 45 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.55158480 |
| 46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.54414781 |
| 47 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.53200773 |
| 48 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.47978768 |
| 49 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.47420675 |
| 50 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.46032857 |
| 51 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.45747656 |
| 52 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.45612399 |
| 53 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.45367580 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.44629724 |
| 55 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.39695231 |
| 56 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.39105521 |
| 57 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38514727 |
| 58 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.37385413 |
| 59 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.37163736 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.36719067 |
| 61 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.36683032 |
| 62 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.35500292 |
| 63 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30884754 |
| 64 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.28894613 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.28605337 |
| 66 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.28354571 |
| 67 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.26507082 |
| 68 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.25057443 |
| 69 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.24745751 |
| 70 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.23596156 |
| 71 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.23071570 |
| 72 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.21588045 |
| 73 | SPI1_23127762_ChIP-Seq_K562_Human | 1.20034724 |
| 74 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.19195439 |
| 75 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.18740616 |
| 76 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.18118558 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17130543 |
| 78 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.16473131 |
| 79 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.15388982 |
| 80 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.14680804 |
| 81 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.13541186 |
| 82 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.09625045 |
| 83 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.09278969 |
| 84 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.07999797 |
| 85 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.04329572 |
| 86 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.02356588 |
| 87 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.02127056 |
| 88 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.01414536 |
| 89 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.98168463 |
| 90 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.96182991 |
| 91 | GATA3_26560356_Chip-Seq_TH1_Human | 0.95449473 |
| 92 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.94720921 |
| 93 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.94277566 |
| 94 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.93437875 |
| 95 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.92186993 |
| 96 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.91287265 |
| 97 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90941149 |
| 98 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.89884139 |
| 99 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.88703098 |
| 100 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.88333726 |
| 101 | GATA1_19941826_ChIP-Seq_K562_Human | 0.87722003 |
| 102 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.86663451 |
| 103 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.85738319 |
| 104 | GATA3_26560356_Chip-Seq_TH2_Human | 0.85663798 |
| 105 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85218194 |
| 106 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.84230658 |
| 107 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.84044675 |
| 108 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.83982397 |
| 109 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83425047 |
| 110 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83091222 |
| 111 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.82956808 |
| 112 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.82758847 |
| 113 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.82236454 |
| 114 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.81910034 |
| 115 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.80865729 |
| 116 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.80628081 |
| 117 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.79612995 |
| 118 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.79455812 |
| 119 | GATA2_19941826_ChIP-Seq_K562_Human | 0.79230487 |
| 120 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78999690 |
| 121 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.78635238 |
| 122 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77842268 |
| 123 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.77299181 |
| 124 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.76892669 |
| 125 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.76068398 |
| 126 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.76056526 |
| 127 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.75933922 |
| 128 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.75493768 |
| 129 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.75268993 |
| 130 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.74459206 |
| 131 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.68565163 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 5.73252486 |
| 2 | MP0005671_abnormal_response_to | 4.90975742 |
| 3 | MP0000685_abnormal_immune_system | 4.07059240 |
| 4 | MP0002166_altered_tumor_susceptibility | 3.66404113 |
| 5 | MP0000703_abnormal_thymus_morphology | 3.32318549 |
| 6 | MP0001835_abnormal_antigen_presentation | 3.27056517 |
| 7 | MP0002398_abnormal_bone_marrow | 3.00157890 |
| 8 | MP0009333_abnormal_splenocyte_physiolog | 2.95552044 |
| 9 | MP0002006_tumorigenesis | 2.94706686 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.82722694 |
| 11 | MP0009785_altered_susceptibility_to | 2.77556952 |
| 12 | MP0004381_abnormal_hair_follicle | 2.73968063 |
| 13 | MP0001800_abnormal_humoral_immune | 2.64519320 |
| 14 | MP0002722_abnormal_immune_system | 2.63263463 |
| 15 | MP0002420_abnormal_adaptive_immunity | 2.59000655 |
| 16 | MP0005000_abnormal_immune_tolerance | 2.58409545 |
| 17 | MP0001819_abnormal_immune_cell | 2.56352625 |
| 18 | MP0000716_abnormal_immune_system | 2.52077789 |
| 19 | MP0003724_increased_susceptibility_to | 2.51805575 |
| 20 | MP0002723_abnormal_immune_serum | 2.44645118 |
| 21 | MP0001790_abnormal_immune_system | 2.42723444 |
| 22 | MP0005387_immune_system_phenotype | 2.42723444 |
| 23 | MP0002405_respiratory_system_inflammati | 2.38023111 |
| 24 | MP0000689_abnormal_spleen_morphology | 2.27100445 |
| 25 | MP0005025_abnormal_response_to | 2.24921520 |
| 26 | MP0004947_skin_inflammation | 2.23763809 |
| 27 | MP0002452_abnormal_antigen_presenting | 2.10580039 |
| 28 | MP0010155_abnormal_intestine_physiology | 2.08368164 |
| 29 | MP0002429_abnormal_blood_cell | 2.05252205 |
| 30 | MP0000569_abnormal_digit_pigmentation | 2.04300724 |
| 31 | MP0003866_abnormal_defecation | 2.04082282 |
| 32 | MP0008260_abnormal_autophagy | 1.91288799 |
| 33 | MP0010352_gastrointestinal_tract_polyps | 1.88643319 |
| 34 | MP0010094_abnormal_chromosome_stability | 1.86099669 |
| 35 | MP0003303_peritoneal_inflammation | 1.85563582 |
| 36 | MP0001853_heart_inflammation | 1.76403545 |
| 37 | MP0002933_joint_inflammation | 1.68345394 |
| 38 | MP0003183_abnormal_peptide_metabolism | 1.67121495 |
| 39 | MP0006082_CNS_inflammation | 1.64638846 |
| 40 | MP0005409_darkened_coat_color | 1.62916294 |
| 41 | MP0000858_altered_metastatic_potential | 1.60214745 |
| 42 | MP0008007_abnormal_cellular_replicative | 1.58321431 |
| 43 | MP0005310_abnormal_salivary_gland | 1.53155895 |
| 44 | MP0005451_abnormal_body_composition | 1.51106095 |
| 45 | MP0004510_myositis | 1.50490443 |
| 46 | MP0005464_abnormal_platelet_physiology | 1.49043119 |
| 47 | MP0001845_abnormal_inflammatory_respons | 1.43919377 |
| 48 | MP0004808_abnormal_hematopoietic_stem | 1.42958532 |
| 49 | MP0003300_gastrointestinal_ulcer | 1.40427429 |
| 50 | MP0002419_abnormal_innate_immunity | 1.38315609 |
| 51 | MP0001873_stomach_inflammation | 1.37267693 |
| 52 | MP0003693_abnormal_embryo_hatching | 1.33893080 |
| 53 | MP0002019_abnormal_tumor_incidence | 1.30297638 |
| 54 | MP0002909_abnormal_adrenal_gland | 1.26792526 |
| 55 | MP0005397_hematopoietic_system_phenotyp | 1.23419204 |
| 56 | MP0001545_abnormal_hematopoietic_system | 1.23419204 |
| 57 | MP0003436_decreased_susceptibility_to | 1.20236587 |
| 58 | MP0005075_abnormal_melanosome_morpholog | 1.19824447 |
| 59 | MP0003077_abnormal_cell_cycle | 1.19324109 |
| 60 | MP0003172_abnormal_lysosome_physiology | 1.18231555 |
| 61 | MP0004957_abnormal_blastocyst_morpholog | 1.17388249 |
| 62 | MP0002148_abnormal_hypersensitivity_rea | 1.13965209 |
| 63 | MP0003111_abnormal_nucleus_morphology | 1.10585344 |
| 64 | MP0003448_altered_tumor_morphology | 1.08945589 |
| 65 | MP0005166_decreased_susceptibility_to | 1.04926714 |
| 66 | MP0009278_abnormal_bone_marrow | 1.01187047 |
| 67 | MP0001851_eye_inflammation | 1.01137542 |
| 68 | MP0004883_abnormal_blood_vessel | 0.92629558 |
| 69 | MP0008469_abnormal_protein_level | 0.90939695 |
| 70 | MP0005076_abnormal_cell_differentiation | 0.89059157 |
| 71 | MP0003656_abnormal_erythrocyte_physiolo | 0.88594438 |
| 72 | MP0000490_abnormal_crypts_of | 0.88174736 |
| 73 | MP0009763_increased_sensitivity_to | 0.81394497 |
| 74 | MP0002095_abnormal_skin_pigmentation | 0.81219172 |
| 75 | MP0008058_abnormal_DNA_repair | 0.81155747 |
| 76 | MP0002132_abnormal_respiratory_system | 0.81137127 |
| 77 | MP0000015_abnormal_ear_pigmentation | 0.80367085 |
| 78 | MP0005023_abnormal_wound_healing | 0.78882639 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 0.76565309 |
| 80 | MP0008057_abnormal_DNA_replication | 0.74803370 |
| 81 | MP0005174_abnormal_tail_pigmentation | 0.74385194 |
| 82 | MP0000383_abnormal_hair_follicle | 0.73869898 |
| 83 | MP0003329_amyloid_beta_deposits | 0.73504263 |
| 84 | MP0006292_abnormal_olfactory_placode | 0.73412940 |
| 85 | MP0000313_abnormal_cell_death | 0.72575243 |
| 86 | MP0003806_abnormal_nucleotide_metabolis | 0.70882032 |
| 87 | MP0003787_abnormal_imprinting | 0.69640747 |
| 88 | MP0000477_abnormal_intestine_morphology | 0.69022073 |
| 89 | MP0008004_abnormal_stomach_pH | 0.67851500 |
| 90 | MP0010234_abnormal_vibrissa_follicle | 0.65011555 |
| 91 | MP0005220_abnormal_exocrine_pancreas | 0.64910086 |
| 92 | MP0001663_abnormal_digestive_system | 0.64838196 |
| 93 | MP0005058_abnormal_lysosome_morphology | 0.63759359 |
| 94 | MP0001730_embryonic_growth_arrest | 0.63461714 |
| 95 | MP0001919_abnormal_reproductive_system | 0.62104327 |
| 96 | MP0009764_decreased_sensitivity_to | 0.62034666 |
| 97 | MP0009765_abnormal_xenobiotic_induced | 0.60828837 |
| 98 | MP0001533_abnormal_skeleton_physiology | 0.60824557 |
| 99 | MP0008877_abnormal_DNA_methylation | 0.59439959 |
| 100 | MP0002693_abnormal_pancreas_physiology | 0.55476194 |
| 101 | MP0002138_abnormal_hepatobiliary_system | 0.55302319 |
| 102 | MP0000350_abnormal_cell_proliferation | 0.54777678 |
| 103 | MP0010307_abnormal_tumor_latency | 0.54766309 |
| 104 | MP0000465_gastrointestinal_hemorrhage | 0.54747613 |
| 105 | MP0002163_abnormal_gland_morphology | 0.54172516 |
| 106 | MP0000609_abnormal_liver_physiology | 0.53173735 |
| 107 | MP0005164_abnormal_response_to | 0.51718578 |
| 108 | MP0000604_amyloidosis | 0.51519027 |
| 109 | MP0008770_decreased_survivor_rate | 0.51089334 |
| 110 | MP0008873_increased_physiological_sensi | 0.50930490 |
| 111 | MP0003221_abnormal_cardiomyocyte_apopto | 0.50332337 |
| 112 | MP0002009_preneoplasia | 0.48995481 |
| 113 | MP0009840_abnormal_foam_cell | 0.48952927 |
| 114 | MP0002928_abnormal_bile_duct | 0.48256542 |
| 115 | MP0001849_ear_inflammation | 0.47673018 |
| 116 | MP0003075_altered_response_to | 0.47600993 |
| 117 | MP0003795_abnormal_bone_structure | 0.46626990 |
| 118 | MP0002998_abnormal_bone_remodeling | 0.46372493 |
| 119 | MP0001243_abnormal_dermal_layer | 0.46340401 |
| 120 | MP0004130_abnormal_muscle_cell | 0.45126385 |
| 121 | MP0002136_abnormal_kidney_physiology | 0.44675322 |
| 122 | MP0003045_fibrosis | 0.44377958 |
| 123 | MP0003959_abnormal_lean_body | 0.42622230 |
| 124 | MP0004484_altered_response_of | 0.42244766 |
| 125 | MP0003828_pulmonary_edema | 0.41955878 |
| 126 | MP0003690_abnormal_glial_cell | 0.41788287 |
| 127 | MP0003252_abnormal_bile_duct | 0.41336720 |
| 128 | MP0000371_diluted_coat_color | 0.41010983 |
| 129 | MP0008874_decreased_physiological_sensi | 0.40630472 |
| 130 | MP0000249_abnormal_blood_vessel | 0.40301011 |
| 131 | MP0005376_homeostasis/metabolism_phenot | 0.37361423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 8.23298958 |
| 2 | Severe combined immunodeficiency (HP:0004430) | 8.18281386 |
| 3 | Abnormality of T cell number (HP:0011839) | 7.82625573 |
| 4 | Combined immunodeficiency (HP:0005387) | 7.35358433 |
| 5 | Thyroiditis (HP:0100646) | 6.49143699 |
| 6 | IgG deficiency (HP:0004315) | 6.35033103 |
| 7 | Hypoplasia of the thymus (HP:0000778) | 5.75728744 |
| 8 | Abnormality of T cells (HP:0002843) | 5.75565957 |
| 9 | Abnormality of B cell number (HP:0010975) | 5.65922405 |
| 10 | B lymphocytopenia (HP:0010976) | 5.65922405 |
| 11 | Autoimmune hemolytic anemia (HP:0001890) | 5.33694219 |
| 12 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.28089145 |
| 13 | Recurrent bronchitis (HP:0002837) | 4.98860111 |
| 14 | Increased IgM level (HP:0003496) | 4.89899335 |
| 15 | Gastrointestinal infarctions (HP:0005244) | 4.60595169 |
| 16 | Abnormality of eosinophils (HP:0001879) | 4.54714365 |
| 17 | Recurrent bacterial skin infections (HP:0005406) | 4.45199163 |
| 18 | Stomatitis (HP:0010280) | 4.37338860 |
| 19 | Recurrent fungal infections (HP:0002841) | 4.22616575 |
| 20 | IgM deficiency (HP:0002850) | 4.05624824 |
| 21 | Panhypogammaglobulinemia (HP:0003139) | 3.84930043 |
| 22 | Chronic diarrhea (HP:0002028) | 3.81878470 |
| 23 | Abnormality of T cell physiology (HP:0011840) | 3.79851594 |
| 24 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.75616850 |
| 25 | Recurrent cutaneous fungal infections (HP:0011370) | 3.75616850 |
| 26 | Spontaneous hematomas (HP:0007420) | 3.74786670 |
| 27 | Abnormality of the fingertips (HP:0001211) | 3.73729561 |
| 28 | Abnormality of macrophages (HP:0004311) | 3.69535013 |
| 29 | Leukocytosis (HP:0001974) | 3.58853062 |
| 30 | Mediastinal lymphadenopathy (HP:0100721) | 3.45746314 |
| 31 | Eosinophilia (HP:0001880) | 3.42122906 |
| 32 | IgA deficiency (HP:0002720) | 3.39311921 |
| 33 | Lymphopenia (HP:0001888) | 3.38383820 |
| 34 | Acute hepatic failure (HP:0006554) | 3.37161594 |
| 35 | Recurrent viral infections (HP:0004429) | 3.36968681 |
| 36 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.27158330 |
| 37 | Chest pain (HP:0100749) | 3.19775576 |
| 38 | Hypoproteinemia (HP:0003075) | 3.12409093 |
| 39 | Pulmonary infiltrates (HP:0002113) | 3.09014453 |
| 40 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.03235565 |
| 41 | Eczematoid dermatitis (HP:0000976) | 3.01708789 |
| 42 | Arterial thrombosis (HP:0004420) | 3.01183134 |
| 43 | Myositis (HP:0100614) | 2.99893146 |
| 44 | Pulmonary embolism (HP:0002204) | 2.98370753 |
| 45 | Chronic otitis media (HP:0000389) | 2.96576647 |
| 46 | Autoimmune thrombocytopenia (HP:0001973) | 2.96314761 |
| 47 | Amyotrophic lateral sclerosis (HP:0007354) | 2.93871582 |
| 48 | Lymphoma (HP:0002665) | 2.93600483 |
| 49 | Hypergammaglobulinemia (HP:0010702) | 2.86706931 |
| 50 | Granulocytopenia (HP:0001913) | 2.86301791 |
| 51 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.81409248 |
| 52 | Keratoconjunctivitis (HP:0001096) | 2.73950194 |
| 53 | Reticulocytopenia (HP:0001896) | 2.72666984 |
| 54 | Increased IgE level (HP:0003212) | 2.71590664 |
| 55 | Abnormality of the columella (HP:0009929) | 2.71232470 |
| 56 | Bronchitis (HP:0012387) | 2.71074639 |
| 57 | Recurrent otitis media (HP:0000403) | 2.69785303 |
| 58 | Epistaxis (HP:0000421) | 2.62892207 |
| 59 | Nasal polyposis (HP:0100582) | 2.61064697 |
| 60 | Gangrene (HP:0100758) | 2.56532265 |
| 61 | Abnormality of the prostate (HP:0008775) | 2.55805292 |
| 62 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.53708039 |
| 63 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.47681423 |
| 64 | Gingival bleeding (HP:0000225) | 2.45448584 |
| 65 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.45142481 |
| 66 | Anorexia (HP:0002039) | 2.44157234 |
| 67 | Inflammation of the large intestine (HP:0002037) | 2.41651505 |
| 68 | Joint swelling (HP:0001386) | 2.37819960 |
| 69 | Abnormality of the pleura (HP:0002103) | 2.34452918 |
| 70 | Basal cell carcinoma (HP:0002671) | 2.34187392 |
| 71 | Oral leukoplakia (HP:0002745) | 2.33857921 |
| 72 | Meningitis (HP:0001287) | 2.32869542 |
| 73 | Bicuspid aortic valve (HP:0001647) | 2.30318050 |
| 74 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.28872289 |
| 75 | Prolonged bleeding time (HP:0003010) | 2.28688079 |
| 76 | Gastrointestinal inflammation (HP:0004386) | 2.27058674 |
| 77 | Urticaria (HP:0001025) | 2.22979779 |
| 78 | Abnormal number of erythroid precursors (HP:0012131) | 2.19625959 |
| 79 | Recurrent skin infections (HP:0001581) | 2.14621367 |
| 80 | Agammaglobulinemia (HP:0004432) | 2.13419946 |
| 81 | Hypochromic microcytic anemia (HP:0004840) | 2.12718538 |
| 82 | Abnormality of the nasal mucosa (HP:0000433) | 2.12508902 |
| 83 | Hypochromic anemia (HP:0001931) | 2.12200327 |
| 84 | Microcytic anemia (HP:0001935) | 2.10178925 |
| 85 | Aplastic anemia (HP:0001915) | 2.10118307 |
| 86 | Poikiloderma (HP:0001029) | 2.08879359 |
| 87 | Slow saccadic eye movements (HP:0000514) | 2.08705405 |
| 88 | Gingivitis (HP:0000230) | 2.06049679 |
| 89 | Colitis (HP:0002583) | 2.05248423 |
| 90 | Glomerulopathy (HP:0100820) | 2.05119239 |
| 91 | Muscle fiber atrophy (HP:0100295) | 2.02662825 |
| 92 | Abnormality of the thymus (HP:0000777) | 1.99853142 |
| 93 | Recurrent abscess formation (HP:0002722) | 1.98336114 |
| 94 | Cellulitis (HP:0100658) | 1.98185506 |
| 95 | Pustule (HP:0200039) | 1.97597826 |
| 96 | Large eyes (HP:0001090) | 1.97151906 |
| 97 | Papilloma (HP:0012740) | 1.96322905 |
| 98 | Verrucae (HP:0200043) | 1.96322905 |
| 99 | Type 2 muscle fiber atrophy (HP:0003554) | 1.95562434 |
| 100 | Thrombophlebitis (HP:0004418) | 1.94538379 |
| 101 | Papilledema (HP:0001085) | 1.94360428 |
| 102 | Recurrent sinusitis (HP:0011108) | 1.91941430 |
| 103 | Premature graying of hair (HP:0002216) | 1.90954171 |
| 104 | Cellular immunodeficiency (HP:0005374) | 1.89392702 |
| 105 | Keratitis (HP:0000491) | 1.88555795 |
| 106 | Retrobulbar optic neuritis (HP:0100654) | 1.87949103 |
| 107 | Optic neuritis (HP:0100653) | 1.87949103 |
| 108 | Prominent nose (HP:0000448) | 1.87118146 |
| 109 | Chronic obstructive pulmonary disease (HP:0006510) | 1.86403691 |
| 110 | Obstructive lung disease (HP:0006536) | 1.86403691 |
| 111 | Macrocytic anemia (HP:0001972) | 1.83833734 |
| 112 | Orchitis (HP:0100796) | 1.82873251 |
| 113 | Diplopia (HP:0000651) | 1.80627656 |
| 114 | Abnormality of binocular vision (HP:0011514) | 1.80627656 |
| 115 | Vasculitis (HP:0002633) | 1.79461432 |
| 116 | Dysautonomia (HP:0002459) | 1.78324621 |
| 117 | Squamous cell carcinoma (HP:0002860) | 1.77299304 |
| 118 | Amaurosis fugax (HP:0100576) | 1.77193163 |
| 119 | Sepsis (HP:0100806) | 1.73180961 |
| 120 | Encephalitis (HP:0002383) | 1.72571177 |
| 121 | Increased density of long bones (HP:0006392) | 1.71493936 |
| 122 | Radial bowing (HP:0002986) | 1.71036930 |
| 123 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.69705257 |
| 124 | Hepatitis (HP:0012115) | 1.66403384 |
| 125 | Entropion (HP:0000621) | 1.65526296 |
| 126 | Petechiae (HP:0000967) | 1.62464077 |
| 127 | Basal ganglia calcification (HP:0002135) | 1.60246059 |
| 128 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.59637494 |
| 129 | Keratoconjunctivitis sicca (HP:0001097) | 1.59047467 |
| 130 | Pulmonary fibrosis (HP:0002206) | 1.55324674 |
| 131 | Hemoptysis (HP:0002105) | 1.55153634 |
| 132 | Increased nuchal translucency (HP:0010880) | 1.54676773 |
| 133 | Albinism (HP:0001022) | 1.52429718 |
| 134 | Cutis marmorata (HP:0000965) | 1.51666834 |
| 135 | Pseudobulbar signs (HP:0002200) | 1.51416711 |
| 136 | Skin ulcer (HP:0200042) | 1.48826771 |
| 137 | Premature skin wrinkling (HP:0100678) | 1.48434190 |
| 138 | Abnormal platelet function (HP:0011869) | 1.46912946 |
| 139 | Impaired platelet aggregation (HP:0003540) | 1.46912946 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.33858563 |
| 2 | MAP4K1 | 5.22560578 |
| 3 | ZAP70 | 3.89155754 |
| 4 | TESK2 | 3.88309754 |
| 5 | KDR | 3.88204760 |
| 6 | RIPK4 | 3.66799236 |
| 7 | MAP3K12 | 2.75846794 |
| 8 | GRK6 | 2.56688478 |
| 9 | TLK1 | 2.34722811 |
| 10 | EEF2K | 2.31518866 |
| 11 | ITK | 2.23313807 |
| 12 | FGFR4 | 2.06591414 |
| 13 | BLK | 2.01442884 |
| 14 | CDC7 | 1.92558766 |
| 15 | SYK | 1.80926833 |
| 16 | MAP3K10 | 1.76539082 |
| 17 | TESK1 | 1.75111133 |
| 18 | CAMKK2 | 1.74869434 |
| 19 | IKBKE | 1.73838256 |
| 20 | MARK3 | 1.66717920 |
| 21 | LRRK2 | 1.63054697 |
| 22 | LCK | 1.61421731 |
| 23 | PRPF4B | 1.61315332 |
| 24 | STK10 | 1.57704215 |
| 25 | MST4 | 1.46879441 |
| 26 | JAK1 | 1.46398076 |
| 27 | TYK2 | 1.46132554 |
| 28 | JAK3 | 1.44797928 |
| 29 | FGFR3 | 1.43026234 |
| 30 | PKN2 | 1.41500747 |
| 31 | SCYL2 | 1.40560289 |
| 32 | PIK3CG | 1.39746822 |
| 33 | RPS6KB2 | 1.36710229 |
| 34 | FGR | 1.34034554 |
| 35 | TSSK6 | 1.32917450 |
| 36 | MAP3K1 | 1.31373775 |
| 37 | EIF2AK1 | 1.30496263 |
| 38 | NME2 | 1.23456853 |
| 39 | MAP2K3 | 1.23453696 |
| 40 | NLK | 1.21900578 |
| 41 | BTK | 1.21441916 |
| 42 | TEC | 1.19704200 |
| 43 | IRAK4 | 1.19288250 |
| 44 | HCK | 1.11456631 |
| 45 | CSK | 1.10649954 |
| 46 | PRKCH | 1.10485522 |
| 47 | BMPR2 | 1.09933617 |
| 48 | FGFR2 | 1.05294366 |
| 49 | LIMK1 | 1.00041460 |
| 50 | MAP3K3 | 0.99443584 |
| 51 | BUB1 | 0.99241446 |
| 52 | CLK1 | 0.98481472 |
| 53 | NEK2 | 0.97318232 |
| 54 | TBK1 | 0.97111598 |
| 55 | MAP3K7 | 0.94510978 |
| 56 | ILK | 0.92900634 |
| 57 | PRKCQ | 0.91961856 |
| 58 | MELK | 0.87685594 |
| 59 | MAP3K5 | 0.85102160 |
| 60 | RPS6KA4 | 0.84986331 |
| 61 | DAPK3 | 0.80564013 |
| 62 | PDGFRB | 0.80469507 |
| 63 | CAMKK1 | 0.80201369 |
| 64 | STK4 | 0.79692858 |
| 65 | EIF2AK3 | 0.77794241 |
| 66 | LYN | 0.77668241 |
| 67 | SIK2 | 0.75314123 |
| 68 | TNK2 | 0.73599093 |
| 69 | MAP3K2 | 0.73469191 |
| 70 | MAPK11 | 0.73332475 |
| 71 | TAOK1 | 0.72015102 |
| 72 | MATK | 0.70812525 |
| 73 | HIPK2 | 0.68847625 |
| 74 | FYN | 0.68390397 |
| 75 | FGFR1 | 0.68134933 |
| 76 | RPS6KA5 | 0.63644336 |
| 77 | IKBKB | 0.63377985 |
| 78 | KSR2 | 0.62684626 |
| 79 | ZAK | 0.62399124 |
| 80 | PTK6 | 0.60778268 |
| 81 | ATR | 0.60611497 |
| 82 | MYLK | 0.57958220 |
| 83 | CDK4 | 0.57104206 |
| 84 | KIT | 0.56907870 |
| 85 | TRIB3 | 0.56117891 |
| 86 | CSNK1G3 | 0.55523335 |
| 87 | CDK12 | 0.53584299 |
| 88 | JAK2 | 0.53326090 |
| 89 | INSR | 0.52666625 |
| 90 | CSNK1A1L | 0.52324463 |
| 91 | TRPM7 | 0.51112532 |
| 92 | AURKB | 0.51055363 |
| 93 | CDK9 | 0.50562028 |
| 94 | GRK7 | 0.49598080 |
| 95 | PIM1 | 0.48864614 |
| 96 | STK16 | 0.48064692 |
| 97 | FRK | 0.48049131 |
| 98 | TYRO3 | 0.47827264 |
| 99 | DAPK1 | 0.47782752 |
| 100 | MAPK12 | 0.46764041 |
| 101 | MAP3K8 | 0.45540057 |
| 102 | TGFBR2 | 0.44631304 |
| 103 | FES | 0.44304002 |
| 104 | PAK4 | 0.44227839 |
| 105 | MAP3K13 | 0.42445410 |
| 106 | EGFR | 0.42370829 |
| 107 | MAPKAPK2 | 0.41905562 |
| 108 | EPHB1 | 0.41871928 |
| 109 | NTRK2 | 0.41117524 |
| 110 | CDK6 | 0.39576588 |
| 111 | SGK2 | 0.38767457 |
| 112 | PASK | 0.38532715 |
| 113 | PDK1 | 0.38256267 |
| 114 | TAOK2 | 0.37013407 |
| 115 | ALK | 0.36407543 |
| 116 | SGK223 | 0.36037762 |
| 117 | SGK494 | 0.36037762 |
| 118 | CAMK4 | 0.35955367 |
| 119 | SGK3 | 0.35594416 |
| 120 | WNK1 | 0.34603271 |
| 121 | RAF1 | 0.32638808 |
| 122 | CSF1R | 0.32065625 |
| 123 | GRK5 | 0.31688436 |
| 124 | MARK2 | 0.31681347 |
| 125 | MAPKAPK3 | 0.31443818 |
| 126 | DYRK3 | 0.30893303 |
| 127 | PINK1 | 0.30712774 |
| 128 | VRK1 | 0.30280819 |
| 129 | SIK3 | 0.29647699 |
| 130 | CDK8 | 0.29365548 |
| 131 | CSNK1G1 | 0.28606817 |
| 132 | MAP3K11 | 0.28482314 |
| 133 | STK11 | 0.27203317 |
| 134 | CSNK1G2 | 0.26569745 |
| 135 | ROCK1 | 0.26220529 |
| 136 | ATM | 0.25993028 |
| 137 | YES1 | 0.25381477 |
| 138 | ADRBK2 | 0.24540359 |
| 139 | TAOK3 | 0.23592192 |
| 140 | MAPK3 | 0.23508611 |
| 141 | MAP3K14 | 0.23033661 |
| 142 | CHEK1 | 0.22011573 |
| 143 | MAPK4 | 0.21818223 |
| 144 | CDK2 | 0.21687753 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.93574772 |
| 2 | Non-homologous end-joining_Homo sapiens_hsa03450 | 4.13265619 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.98510771 |
| 4 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.25528004 |
| 5 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.21109260 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.86822622 |
| 7 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.76331221 |
| 8 | Measles_Homo sapiens_hsa05162 | 2.73584160 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.48351646 |
| 10 | Viral myocarditis_Homo sapiens_hsa05416 | 2.28533617 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.21749976 |
| 12 | Allograft rejection_Homo sapiens_hsa05330 | 2.10062101 |
| 13 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.00366227 |
| 14 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.90796273 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.85199635 |
| 16 | Mismatch repair_Homo sapiens_hsa03430 | 1.83303160 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 1.76635306 |
| 18 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.75068978 |
| 19 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.72193735 |
| 20 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.53511566 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 1.41840915 |
| 22 | Proteasome_Homo sapiens_hsa03050 | 1.36069453 |
| 23 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.31891198 |
| 24 | HTLV-I infection_Homo sapiens_hsa05166 | 1.29200138 |
| 25 | Asthma_Homo sapiens_hsa05310 | 1.27171892 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.25174179 |
| 27 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.24395588 |
| 28 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.22336161 |
| 29 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.18205933 |
| 30 | Leishmaniasis_Homo sapiens_hsa05140 | 1.14329406 |
| 31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.11153949 |
| 32 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.09955744 |
| 33 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.09741387 |
| 34 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.06293141 |
| 35 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.06059887 |
| 36 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.05943904 |
| 37 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.05512118 |
| 38 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.98183118 |
| 39 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.97127439 |
| 40 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.96574108 |
| 41 | Homologous recombination_Homo sapiens_hsa03440 | 0.96257507 |
| 42 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.95766100 |
| 43 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.94583709 |
| 44 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.93448203 |
| 45 | Colorectal cancer_Homo sapiens_hsa05210 | 0.92649964 |
| 46 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.90607982 |
| 47 | Cell cycle_Homo sapiens_hsa04110 | 0.87559123 |
| 48 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.86724038 |
| 49 | Hepatitis B_Homo sapiens_hsa05161 | 0.85838901 |
| 50 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.85290731 |
| 51 | Alcoholism_Homo sapiens_hsa05034 | 0.85213598 |
| 52 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.80695258 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.80584702 |
| 54 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.79945785 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.78470548 |
| 56 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.74659529 |
| 57 | Pertussis_Homo sapiens_hsa05133 | 0.74580913 |
| 58 | Apoptosis_Homo sapiens_hsa04210 | 0.73763585 |
| 59 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73411529 |
| 60 | Glioma_Homo sapiens_hsa05214 | 0.73298560 |
| 61 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.70511985 |
| 62 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.70237865 |
| 63 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.70184446 |
| 64 | RNA degradation_Homo sapiens_hsa03018 | 0.68062416 |
| 65 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.66634192 |
| 66 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.66567280 |
| 67 | Shigellosis_Homo sapiens_hsa05131 | 0.64315239 |
| 68 | Phagosome_Homo sapiens_hsa04145 | 0.64080780 |
| 69 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.62565053 |
| 70 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.61840213 |
| 71 | RNA transport_Homo sapiens_hsa03013 | 0.60460671 |
| 72 | Olfactory transduction_Homo sapiens_hsa04740 | 0.58886739 |
| 73 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.58840412 |
| 74 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.58514085 |
| 75 | Thyroid cancer_Homo sapiens_hsa05216 | 0.58394063 |
| 76 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.57416299 |
| 77 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.55812960 |
| 78 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.52629093 |
| 79 | Prostate cancer_Homo sapiens_hsa05215 | 0.51030528 |
| 80 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.50266747 |
| 81 | RNA polymerase_Homo sapiens_hsa03020 | 0.49839737 |
| 82 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48460669 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.47572674 |
| 84 | Platelet activation_Homo sapiens_hsa04611 | 0.46247362 |
| 85 | Malaria_Homo sapiens_hsa05144 | 0.44796970 |
| 86 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.43629345 |
| 87 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.43548453 |
| 88 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.41556066 |
| 89 | Influenza A_Homo sapiens_hsa05164 | 0.40982348 |
| 90 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.39361881 |
| 91 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.39236292 |
| 92 | Legionellosis_Homo sapiens_hsa05134 | 0.36599431 |
| 93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.35070506 |
| 94 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.34463960 |
| 95 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.34012307 |
| 96 | Endocytosis_Homo sapiens_hsa04144 | 0.33742809 |
| 97 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.33353394 |
| 98 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.32862239 |
| 99 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.31951258 |
| 100 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.31313481 |
| 101 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.29737407 |
| 102 | Prion diseases_Homo sapiens_hsa05020 | 0.29235960 |
| 103 | Phototransduction_Homo sapiens_hsa04744 | 0.29186185 |
| 104 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.29076772 |
| 105 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.28947637 |
| 106 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.28653640 |
| 107 | Renin secretion_Homo sapiens_hsa04924 | 0.28468882 |
| 108 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.28420714 |
| 109 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.27146773 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.25916180 |
| 111 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.23581483 |
| 112 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.22637060 |
| 113 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.22376393 |
| 114 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.22099644 |
| 115 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.20976910 |
| 116 | Tuberculosis_Homo sapiens_hsa05152 | 0.17734358 |
| 117 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.17616961 |
| 118 | Salmonella infection_Homo sapiens_hsa05132 | 0.17503508 |
| 119 | Basal transcription factors_Homo sapiens_hsa03022 | 0.15957360 |
| 120 | Long-term potentiation_Homo sapiens_hsa04720 | 0.15616453 |
| 121 | Purine metabolism_Homo sapiens_hsa00230 | 0.14831401 |
| 122 | Endometrial cancer_Homo sapiens_hsa05213 | 0.12451791 |
| 123 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.11014463 |
| 124 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.10204146 |
| 125 | Adherens junction_Homo sapiens_hsa04520 | 0.09264561 |
| 126 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.08914433 |
| 127 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.07666457 |
| 128 | Hepatitis C_Homo sapiens_hsa05160 | 0.07548916 |
| 129 | Pathways in cancer_Homo sapiens_hsa05200 | 0.07133001 |
| 130 | Other glycan degradation_Homo sapiens_hsa00511 | 0.07104099 |
| 131 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.06516772 |

