TRGV4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)6.11287022
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.96405108
3positive regulation of gamma-delta T cell activation (GO:0046645)5.92472193
4regulation of B cell receptor signaling pathway (GO:0050855)5.92333346
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.76614467
6negative regulation of cell killing (GO:0031342)5.76614467
7response to interleukin-15 (GO:0070672)5.76584532
8negative T cell selection (GO:0043383)5.68006941
9cytidine deamination (GO:0009972)5.58675580
10cytidine metabolic process (GO:0046087)5.58675580
11cytidine catabolic process (GO:0006216)5.58675580
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45600216
13positive T cell selection (GO:0043368)5.31118073
14pyrimidine ribonucleoside catabolic process (GO:0046133)5.22756490
15negative thymic T cell selection (GO:0045060)5.21354096
16positive thymic T cell selection (GO:0045059)5.18426227
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.07344898
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01146109
19antigen processing and presentation of endogenous antigen (GO:0019883)4.75590641
20regulation of gamma-delta T cell differentiation (GO:0045586)4.66497840
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60662202
22DNA deamination (GO:0045006)4.54875641
23activated T cell proliferation (GO:0050798)4.52346514
24regulation of gamma-delta T cell activation (GO:0046643)4.46256600
25thymic T cell selection (GO:0045061)4.45349878
26T cell selection (GO:0045058)4.42258571
27mast cell activation involved in immune response (GO:0002279)4.27243620
28mast cell degranulation (GO:0043303)4.27243620
29mast cell activation (GO:0045576)4.27056645
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.26719712
31regulation of natural killer cell mediated immunity (GO:0002715)4.26719712
32negative regulation of T cell mediated immunity (GO:0002710)4.24285713
33negative regulation of T cell apoptotic process (GO:0070233)4.19195168
34positive regulation of B cell differentiation (GO:0045579)4.17421714
35T cell migration (GO:0072678)4.16854978
36regulation of B cell differentiation (GO:0045577)4.16570280
37positive regulation of granulocyte differentiation (GO:0030854)4.11256588
38Arp2/3 complex-mediated actin nucleation (GO:0034314)4.08299086
39regulation of leukocyte mediated cytotoxicity (GO:0001910)4.03458761
40regulation of T cell mediated cytotoxicity (GO:0001914)4.02733548
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.95970756
42positive regulation of natural killer cell mediated immunity (GO:0002717)3.93276641
43regulation of alpha-beta T cell proliferation (GO:0046640)3.92837315
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.89190572
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.87206533
46leukocyte aggregation (GO:0070486)3.75938270
47B cell receptor signaling pathway (GO:0050853)3.74385053
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.73390459
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69810864
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67274745
51regulation of cell killing (GO:0031341)3.66192187
52leukocyte degranulation (GO:0043299)3.65861380
53positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.65498722
54immunoglobulin mediated immune response (GO:0016064)3.64600335
55antigen receptor-mediated signaling pathway (GO:0050851)3.57572971
56T cell receptor signaling pathway (GO:0050852)3.57081940
57positive regulation of cell killing (GO:0031343)3.55130608
58regulation of regulatory T cell differentiation (GO:0045589)3.53346078
59negative regulation of interleukin-12 production (GO:0032695)3.51941660
60negative regulation of leukocyte mediated immunity (GO:0002704)3.46794055
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41182096
62cellular defense response (GO:0006968)3.38533089
63positive regulation of tolerance induction (GO:0002645)3.35960904
64actin nucleation (GO:0045010)3.35804555
65positive regulation of calcium-mediated signaling (GO:0050850)3.35754615
66regulation of T cell tolerance induction (GO:0002664)3.33581191
67positive regulation of defense response to virus by host (GO:0002230)3.30529949
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21832126
69negative regulation of viral genome replication (GO:0045071)3.21176555
70B cell mediated immunity (GO:0019724)3.20740237
71interferon-gamma production (GO:0032609)3.20644115
72regulation of tolerance induction (GO:0002643)3.16202528
73NIK/NF-kappaB signaling (GO:0038061)3.14402624
74regulation of lymphocyte chemotaxis (GO:1901623)3.11060327
75regulation of T cell receptor signaling pathway (GO:0050856)3.08215061
76T cell costimulation (GO:0031295)3.07011492
77lymphocyte chemotaxis (GO:0048247)3.06353950
78myeloid cell activation involved in immune response (GO:0002275)3.05820675
79response to type I interferon (GO:0034340)3.05620891
80type I interferon signaling pathway (GO:0060337)3.05238574
81cellular response to type I interferon (GO:0071357)3.05238574
82regulation of T cell apoptotic process (GO:0070232)3.05103896
83T cell homeostasis (GO:0043029)3.04208851
84antigen processing and presentation via MHC class Ib (GO:0002475)3.03797838
85regulation of T cell chemotaxis (GO:0010819)3.03497248
86positive regulation of T cell chemotaxis (GO:0010820)3.03497248
87negative regulation of lymphocyte apoptotic process (GO:0070229)3.03236973
88lymphocyte costimulation (GO:0031294)3.02722222
89regulation of isotype switching to IgG isotypes (GO:0048302)2.96929048
90lymphocyte homeostasis (GO:0002260)2.96069703
91lymphocyte migration (GO:0072676)2.95207320
92negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.94918022
93regulation of interleukin-2 biosynthetic process (GO:0045076)2.92590376
94negative regulation of adaptive immune response (GO:0002820)2.90459636
95regulation of T cell mediated immunity (GO:0002709)2.89694917
96regulation of granulocyte differentiation (GO:0030852)2.88326093
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87274016
98regulation of alpha-beta T cell activation (GO:0046634)2.86671946
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.86637670
100negative regulation of phagocytosis (GO:0050765)2.85849813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.18430513
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.94339870
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.72992574
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.38753216
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.05861851
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.59481779
7RUNX_20019798_ChIP-Seq_JUKART_Human3.50974371
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39326024
9MYB_26560356_Chip-Seq_TH2_Human3.37665206
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00662724
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97983980
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84856769
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.83322395
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69365583
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61095209
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57793714
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56652100
18MYB_26560356_Chip-Seq_TH1_Human2.54174745
19GATA3_27048872_Chip-Seq_THYMUS_Human2.47119035
20UTX_26944678_Chip-Seq_JUKART_Human2.41298320
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.37099436
22MAF_26560356_Chip-Seq_TH1_Human2.36646246
23SPI1_23547873_ChIP-Seq_NB4_Human2.35743187
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23520963
25SCL_19346495_ChIP-Seq_HPC-7_Human2.21719092
26MAF_26560356_Chip-Seq_TH2_Human1.99428736
27GATA3_26560356_Chip-Seq_TH2_Human1.97965548
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97777072
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.92726936
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91584016
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87715545
32SPI1_23127762_ChIP-Seq_K562_Human1.87111483
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82008728
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.80046766
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79985004
36MYC_22102868_ChIP-Seq_BL_Human1.79935583
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75756035
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72139424
39VDR_24763502_ChIP-Seq_THP-1_Human1.61551414
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60706463
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53881581
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42707334
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42491504
44VDR_21846776_ChIP-Seq_THP-1_Human1.41949755
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.37930734
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34828906
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33726981
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30447888
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26995201
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25649871
51CIITA_25753668_ChIP-Seq_RAJI_Human1.20461879
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18308625
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11538609
54VDR_24787735_ChIP-Seq_THP-1_Human1.09920587
55BCL6_27268052_Chip-Seq_Bcells_Human1.09598302
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09377466
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09046364
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08246033
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07701159
60VDR_23849224_ChIP-Seq_CD4+_Human1.07508483
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07293481
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07221907
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06869790
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05484630
65GATA1_22025678_ChIP-Seq_K562_Human1.04041066
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03980066
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01849052
68FOXP3_21729870_ChIP-Seq_TREG_Human1.01460673
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01029809
70PU_27001747_Chip-Seq_BMDM_Mouse0.99308173
71GATA1_19941827_ChIP-Seq_MEL_Mouse0.98994341
72TCF7_22412390_ChIP-Seq_EML_Mouse0.98135039
73GATA1_19941826_ChIP-Seq_K562_Human0.96875905
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95251025
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94408470
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92261438
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91423884
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90625020
79KDM2B_26808549_Chip-Seq_DND41_Human0.89090521
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87745045
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87732455
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85667578
83BCOR_27268052_Chip-Seq_Bcells_Human0.85567417
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84154753
85GATA2_19941826_ChIP-Seq_K562_Human0.84109956
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81951144
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80790317
88GATA3_26560356_Chip-Seq_TH1_Human0.80675461
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80285963
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80089541
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78829794
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78075077
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77937695
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.77191500
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76641740
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76253760
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76065795
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75385856
99P300_27268052_Chip-Seq_Bcells_Human0.75247988
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74523827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.16863162
2MP0001835_abnormal_antigen_presentation4.29622559
3MP0003763_abnormal_thymus_physiology4.12635802
4MP0003724_increased_susceptibility_to3.47456528
5MP0001800_abnormal_humoral_immune3.34757789
6MP0000685_abnormal_immune_system3.20714013
7MP0005000_abnormal_immune_tolerance3.18680480
8MP0005387_immune_system_phenotype3.12108865
9MP0001790_abnormal_immune_system3.12108865
10MP0009785_altered_susceptibility_to3.02702072
11MP0003436_decreased_susceptibility_to2.86262595
12MP0002723_abnormal_immune_serum2.84885219
13MP0002420_abnormal_adaptive_immunity2.81167562
14MP0005025_abnormal_response_to2.79098144
15MP0001819_abnormal_immune_cell2.74723651
16MP0002452_abnormal_antigen_presenting2.59432738
17MP0002148_abnormal_hypersensitivity_rea2.57201866
18MP0002166_altered_tumor_susceptibility2.52859740
19MP0002419_abnormal_innate_immunity2.42568277
20MP0002398_abnormal_bone_marrow2.40288294
21MP0002405_respiratory_system_inflammati2.33654931
22MP0000703_abnormal_thymus_morphology2.28645675
23MP0000716_abnormal_immune_system2.25175069
24MP0004947_skin_inflammation2.21461494
25MP0009333_abnormal_splenocyte_physiolog2.16434883
26MP0004381_abnormal_hair_follicle2.13831981
27MP0005464_abnormal_platelet_physiology2.06169340
28MP0002722_abnormal_immune_system2.04531695
29MP0000689_abnormal_spleen_morphology2.04471813
30MP0006082_CNS_inflammation2.01826073
31MP0010155_abnormal_intestine_physiology1.94396914
32MP0002006_tumorigenesis1.86577869
33MP0001845_abnormal_inflammatory_respons1.79118775
34MP0003866_abnormal_defecation1.79006062
35MP0002429_abnormal_blood_cell1.78594372
36MP0002132_abnormal_respiratory_system1.77411484
37MP0005075_abnormal_melanosome_morpholog1.70394146
38MP0003303_peritoneal_inflammation1.70270402
39MP0002933_joint_inflammation1.56559873
40MP0001873_stomach_inflammation1.54918259
41MP0001533_abnormal_skeleton_physiology1.46795251
42MP0001853_heart_inflammation1.46307293
43MP0002396_abnormal_hematopoietic_system1.42170261
44MP0002138_abnormal_hepatobiliary_system1.36099603
45MP0003300_gastrointestinal_ulcer1.34273798
46MP0005451_abnormal_body_composition1.31692915
47MP0008469_abnormal_protein_level1.22568492
48MP0005310_abnormal_salivary_gland1.18472722
49MP0009764_decreased_sensitivity_to1.18123831
50MP0000569_abnormal_digit_pigmentation1.17706259
51MP0002998_abnormal_bone_remodeling1.10938762
52MP0000858_altered_metastatic_potential1.08360905
53MP0009278_abnormal_bone_marrow1.06226445
54MP0003448_altered_tumor_morphology1.06155510
55MP0002277_abnormal_respiratory_mucosa1.01605234
56MP0000465_gastrointestinal_hemorrhage0.98556009
57MP0009763_increased_sensitivity_to0.96823509
58MP0008260_abnormal_autophagy0.90344596
59MP0003172_abnormal_lysosome_physiology0.90117640
60MP0001851_eye_inflammation0.87506586
61MP0000015_abnormal_ear_pigmentation0.86798219
62MP0002009_preneoplasia0.86184782
63MP0002019_abnormal_tumor_incidence0.80588593
64MP0003045_fibrosis0.79693848
65MP0003183_abnormal_peptide_metabolism0.79478799
66MP0003828_pulmonary_edema0.76892518
67MP0004147_increased_porphyrin_level0.75008872
68MP0005397_hematopoietic_system_phenotyp0.71784456
69MP0001545_abnormal_hematopoietic_system0.71784456
70MP0005166_decreased_susceptibility_to0.69777894
71MP0005174_abnormal_tail_pigmentation0.69489408
72MP0001663_abnormal_digestive_system0.68022530
73MP0004130_abnormal_muscle_cell0.66944197
74MP0003786_premature_aging0.65397351
75MP0009765_abnormal_xenobiotic_induced0.64502434
76MP0002876_abnormal_thyroid_physiology0.63310726
77MP0003656_abnormal_erythrocyte_physiolo0.62142544
78MP0004883_abnormal_blood_vessel0.59491148
79MP0001501_abnormal_sleep_pattern0.58039067
80MP0003806_abnormal_nucleotide_metabolis0.57725810
81MP0004808_abnormal_hematopoietic_stem0.56993905
82MP0000490_abnormal_crypts_of0.56104005
83MP0006035_abnormal_mitochondrial_morpho0.55673274
84MP0008877_abnormal_DNA_methylation0.55596835
85MP0003795_abnormal_bone_structure0.55363703
86MP0000249_abnormal_blood_vessel0.54218023
87MP0004510_myositis0.53985518
88MP0005390_skeleton_phenotype0.53417286
89MP0002877_abnormal_melanocyte_morpholog0.53307062
90MP0008873_increased_physiological_sensi0.53257779
91MP0003646_muscle_fatigue0.52135188
92MP0002136_abnormal_kidney_physiology0.48389847
93MP0002693_abnormal_pancreas_physiology0.48023057
94MP0005164_abnormal_response_to0.47290086
95MP0000920_abnormal_myelination0.45150267
96MP0008995_early_reproductive_senescence0.44420118
97MP0003075_altered_response_to0.43583314
98MP0002095_abnormal_skin_pigmentation0.40741225
99MP0003878_abnormal_ear_physiology0.40615177
100MP0005377_hearing/vestibular/ear_phenot0.40615177

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.18770966
2Abnormality of T cell number (HP:0011839)6.44219375
3Severe combined immunodeficiency (HP:0004430)6.06204058
4Panhypogammaglobulinemia (HP:0003139)5.81550662
5Hypoplasia of the thymus (HP:0000778)5.03688767
6Elevated erythrocyte sedimentation rate (HP:0003565)4.97198868
7Combined immunodeficiency (HP:0005387)4.96675170
8Abnormality of T cells (HP:0002843)4.94770766
9IgG deficiency (HP:0004315)4.87423177
10Recurrent fungal infections (HP:0002841)4.73684721
11Thyroiditis (HP:0100646)4.58612069
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.57768786
13Recurrent viral infections (HP:0004429)4.48011089
14Abnormality of eosinophils (HP:0001879)4.30279047
15Myositis (HP:0100614)4.28208440
16Encephalitis (HP:0002383)4.24626328
17Chronic mucocutaneous candidiasis (HP:0002728)4.14894075
18Recurrent cutaneous fungal infections (HP:0011370)4.14894075
19Eosinophilia (HP:0001880)4.10198936
20Meningitis (HP:0001287)4.06053740
21B lymphocytopenia (HP:0010976)4.00321549
22Granulocytopenia (HP:0001913)3.96928481
23Retrobulbar optic neuritis (HP:0100654)3.95987346
24Optic neuritis (HP:0100653)3.95987346
25Stomatitis (HP:0010280)3.95244717
26Abnormality of B cell number (HP:0010975)3.88486172
27Hypoproteinemia (HP:0003075)3.84035883
28Eczematoid dermatitis (HP:0000976)3.73079908
29Orchitis (HP:0100796)3.68076968
30Agammaglobulinemia (HP:0004432)3.67867564
31Leukocytosis (HP:0001974)3.66705455
32Abnormality of macrophages (HP:0004311)3.62093510
33Autoimmune hemolytic anemia (HP:0001890)3.59148173
34Increased IgM level (HP:0003496)3.48701576
35Recurrent bronchitis (HP:0002837)3.39902508
36Recurrent bacterial skin infections (HP:0005406)3.39611098
37Recurrent abscess formation (HP:0002722)3.33881193
38Aplastic anemia (HP:0001915)3.26057358
39Abnormality of T cell physiology (HP:0011840)3.21866474
40Chronic diarrhea (HP:0002028)3.19345645
41Keratoconjunctivitis sicca (HP:0001097)3.18365418
42Vasculitis (HP:0002633)3.14852038
43Recurrent skin infections (HP:0001581)3.13228619
44Mediastinal lymphadenopathy (HP:0100721)3.12643968
45IgM deficiency (HP:0002850)3.07304444
46Pustule (HP:0200039)3.07211655
47Pulmonary infiltrates (HP:0002113)3.04640671
48Gastrointestinal infarctions (HP:0005244)2.93054278
49Keratoconjunctivitis (HP:0001096)2.92184310
50Obstructive lung disease (HP:0006536)2.92023495
51Chronic obstructive pulmonary disease (HP:0006510)2.92023495
52Lymphopenia (HP:0001888)2.82786928
53Spontaneous hematomas (HP:0007420)2.78405374
54Inflammation of the large intestine (HP:0002037)2.75779803
55Hemoptysis (HP:0002105)2.62118740
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.59489341
57Colitis (HP:0002583)2.59045226
58Lymphoma (HP:0002665)2.58677078
59Gastrointestinal inflammation (HP:0004386)2.51491358
60Aplasia/Hypoplasia of the thymus (HP:0010515)2.49915480
61Increased IgE level (HP:0003212)2.49249454
62Pulmonary embolism (HP:0002204)2.49049747
63Joint swelling (HP:0001386)2.47738737
64Autoimmune thrombocytopenia (HP:0001973)2.42733368
65Hypergammaglobulinemia (HP:0010702)2.40093596
66Acute hepatic failure (HP:0006554)2.33770172
67Prolonged bleeding time (HP:0003010)2.29108647
68Chest pain (HP:0100749)2.26313389
69Petechiae (HP:0000967)2.23728210
70Abnormality of the prostate (HP:0008775)2.21777753
71Gangrene (HP:0100758)2.17504736
72Epistaxis (HP:0000421)2.15450400
73Arterial thrombosis (HP:0004420)2.14235703
74Slow saccadic eye movements (HP:0000514)2.13208056
75Abnormality of the pleura (HP:0002103)2.12911150
76Anorexia (HP:0002039)2.08041437
77Sepsis (HP:0100806)2.05435668
78Bronchitis (HP:0012387)2.02208321
79Alveolar cell carcinoma (HP:0006519)1.99759377
80Purpura (HP:0000979)1.96476284
81Chronic otitis media (HP:0000389)1.95766225
82Chronic sinusitis (HP:0011109)1.95715131
83Basal ganglia calcification (HP:0002135)1.95127950
84Urticaria (HP:0001025)1.92707312
85Papilledema (HP:0001085)1.90032951
86Microcytic anemia (HP:0001935)1.87698539
87Verrucae (HP:0200043)1.87123594
88Papilloma (HP:0012740)1.87123594
89Neoplasm of the tracheobronchial system (HP:0100552)1.86780582
90Skin rash (HP:0000988)1.86128342
91Abnormality of the thymus (HP:0000777)1.85948591
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83909717
93Glomerulopathy (HP:0100820)1.82093258
94Gingival bleeding (HP:0000225)1.81913738
95Keratitis (HP:0000491)1.77601360
96Pulmonary fibrosis (HP:0002206)1.76567441
97Recurrent gram-negative bacterial infections (HP:0005420)1.75543232
98Episodic fever (HP:0001954)1.73440652
99Abnormality of glycosphingolipid metabolism (HP:0004343)1.71232793
100Abnormality of glycolipid metabolism (HP:0010969)1.71232793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.27141453
2MAP4K14.82901215
3RIPK43.88582155
4FES3.31985962
5TAOK33.19473274
6ZAP702.53586062
7CSK2.38383951
8GRK62.27937463
9KDR2.25797063
10NLK2.06755797
11SYK2.06600766
12MAP3K141.98694737
13BTK1.97686127
14ITK1.89066713
15JAK31.86987358
16MAP2K31.72294989
17JAK11.69483637
18IRAK41.66480061
19KIT1.66186592
20BMPR21.65978417
21MAPKAPK31.64920464
22IKBKE1.64444493
23LCK1.64393023
24BLK1.56107042
25IKBKB1.41859620
26MAP3K31.40419130
27TESK21.39122913
28MAP3K131.38313600
29HCK1.38154606
30TYK21.34895641
31LYN1.32501388
32PRKCQ1.30810336
33TNK21.27106180
34MARK31.25975816
35MATK1.12972320
36GRK71.12496103
37MAP3K111.12478169
38ADRBK21.09596681
39TBK11.09272671
40MAP3K101.08776621
41TAOK11.07668918
42TEC1.05235012
43STK100.97001709
44TLK10.94980267
45ZAK0.93964584
46ERN10.90514195
47CSF1R0.90239311
48PIK3CG0.87812661
49FGR0.86042638
50MST40.83737448
51NUAK10.81296651
52CLK10.80553198
53EPHB10.76903858
54JAK20.75693972
55PIM10.73116786
56BMPR1B0.72290033
57MAPK120.71248557
58CDK40.70591148
59MAP3K10.69350637
60FGFR30.69072245
61PDK10.68131895
62SCYL20.66760066
63FGFR40.66658509
64TAOK20.65617375
65MAPK110.65418042
66TGFBR20.62205373
67EPHA30.61446245
68SIK30.58756560
69CAMKK20.58447217
70FYN0.56137766
71MAP3K50.55352314
72TYRO30.55027104
73PRPF4B0.54189030
74MAP2K60.52713744
75NEK60.52244699
76PDGFRB0.51086128
77BCKDK0.49447873
78RPS6KA40.47775186
79MAPKAPK20.45841337
80PTK2B0.44135286
81HIPK20.43782748
82TRPM70.41737208
83MAPK70.40808731
84CDK60.39607948
85DAPK10.38194858
86MUSK0.35928174
87CHUK0.35467839
88STK380.34562056
89SGK20.34001490
90LRRK20.31101330
91EIF2AK30.30851591
92GRK50.29953581
93FRK0.29816408
94INSR0.29723504
95TGFBR10.28428592
96STK40.28197781
97IGF1R0.27829814
98PINK10.25398580
99IRAK10.24366584
100SGK30.21593875

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.69357278
2Graft-versus-host disease_Homo sapiens_hsa053323.53809394
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.43762056
4Allograft rejection_Homo sapiens_hsa053303.23154896
5Autoimmune thyroid disease_Homo sapiens_hsa053203.17921951
6Antigen processing and presentation_Homo sapiens_hsa046123.17785309
7T cell receptor signaling pathway_Homo sapiens_hsa046602.99725880
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.53818523
9Hematopoietic cell lineage_Homo sapiens_hsa046402.52936839
10Type I diabetes mellitus_Homo sapiens_hsa049402.34666919
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31268888
12Measles_Homo sapiens_hsa051622.25870507
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.25177082
14B cell receptor signaling pathway_Homo sapiens_hsa046622.09131411
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03873713
16Leishmaniasis_Homo sapiens_hsa051402.02627936
17Asthma_Homo sapiens_hsa053101.99086507
18Osteoclast differentiation_Homo sapiens_hsa043801.91828420
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74195795
20Malaria_Homo sapiens_hsa051441.71356436
21Staphylococcus aureus infection_Homo sapiens_hsa051501.69914321
22Viral myocarditis_Homo sapiens_hsa054161.63665027
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59705470
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57850091
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.53285235
26Herpes simplex infection_Homo sapiens_hsa051681.51891552
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46508867
28Chemokine signaling pathway_Homo sapiens_hsa040621.42823924
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39398736
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34598412
31Tuberculosis_Homo sapiens_hsa051521.33246095
32Rheumatoid arthritis_Homo sapiens_hsa053231.29031163
33Acute myeloid leukemia_Homo sapiens_hsa052211.28612012
34Shigellosis_Homo sapiens_hsa051311.17424301
35TNF signaling pathway_Homo sapiens_hsa046681.10624312
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06347836
37Toxoplasmosis_Homo sapiens_hsa051451.03667097
38Influenza A_Homo sapiens_hsa051641.03433118
39Apoptosis_Homo sapiens_hsa042101.01731106
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97926032
41Platelet activation_Homo sapiens_hsa046110.96965278
42Hepatitis B_Homo sapiens_hsa051610.84753716
43Legionellosis_Homo sapiens_hsa051340.84010390
44Salmonella infection_Homo sapiens_hsa051320.78646660
45HTLV-I infection_Homo sapiens_hsa051660.76843011
46Pertussis_Homo sapiens_hsa051330.74864101
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71472252
48Regulation of autophagy_Homo sapiens_hsa041400.71436275
49Epstein-Barr virus infection_Homo sapiens_hsa051690.71268647
50Non-small cell lung cancer_Homo sapiens_hsa052230.67358492
51Viral carcinogenesis_Homo sapiens_hsa052030.64082869
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63996065
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.63973922
54African trypanosomiasis_Homo sapiens_hsa051430.61426094
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59788728
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58938103
57Systemic lupus erythematosus_Homo sapiens_hsa053220.58278536
58Olfactory transduction_Homo sapiens_hsa047400.58257925
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58018494
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57928535
61Hepatitis C_Homo sapiens_hsa051600.54248265
62Phagosome_Homo sapiens_hsa041450.51799507
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51706034
64FoxO signaling pathway_Homo sapiens_hsa040680.47153025
65Other glycan degradation_Homo sapiens_hsa005110.44083986
66Endocytosis_Homo sapiens_hsa041440.43201632
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41879444
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.41275394
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.40560378
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40467492
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39028103
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.36453537
73MAPK signaling pathway_Homo sapiens_hsa040100.35190751
74VEGF signaling pathway_Homo sapiens_hsa043700.33833528
75Prolactin signaling pathway_Homo sapiens_hsa049170.33511012
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31793621
77Pancreatic cancer_Homo sapiens_hsa052120.31332226
78Proteasome_Homo sapiens_hsa030500.31088830
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30661167
80Lysosome_Homo sapiens_hsa041420.27417554
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25686684
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.24891996
83Arachidonic acid metabolism_Homo sapiens_hsa005900.23007359
84Insulin resistance_Homo sapiens_hsa049310.22452826
85Phototransduction_Homo sapiens_hsa047440.19758400
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19204319
87Chronic myeloid leukemia_Homo sapiens_hsa052200.18340238
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15619788
89Linoleic acid metabolism_Homo sapiens_hsa005910.14667257
90Oxytocin signaling pathway_Homo sapiens_hsa049210.14077986
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13824841
92Ras signaling pathway_Homo sapiens_hsa040140.12898560
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10719100
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.10330800
95Inositol phosphate metabolism_Homo sapiens_hsa005620.09817470
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08777761
97mTOR signaling pathway_Homo sapiens_hsa041500.07969331
98Long-term potentiation_Homo sapiens_hsa047200.07347175
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06929394
100HIF-1 signaling pathway_Homo sapiens_hsa040660.06020380

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