TRGV5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.58676175
2cytidine metabolic process (GO:0046087)6.58676175
3cytidine catabolic process (GO:0006216)6.58676175
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.25107254
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.92730490
6DNA deamination (GO:0045006)5.45180611
7positive regulation of gamma-delta T cell activation (GO:0046645)5.23670567
8cellular response to interleukin-15 (GO:0071350)5.10787046
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.95865202
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83475645
11regulation of B cell receptor signaling pathway (GO:0050855)4.66834621
12regulation of regulatory T cell differentiation (GO:0045589)4.49552780
13response to interleukin-15 (GO:0070672)4.49212640
14regulation of T cell tolerance induction (GO:0002664)4.29581030
15Arp2/3 complex-mediated actin nucleation (GO:0034314)4.17539497
16T cell migration (GO:0072678)4.15334903
17negative regulation of T cell apoptotic process (GO:0070233)4.14328897
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11410919
19negative regulation of cell killing (GO:0031342)4.11410919
20regulation of chronic inflammatory response (GO:0002676)4.10208151
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.06580423
22regulation of gamma-delta T cell activation (GO:0046643)3.90266363
23regulation of gamma-delta T cell differentiation (GO:0045586)3.89075501
24positive regulation of natural killer cell mediated immunity (GO:0002717)3.88557916
25positive regulation of tolerance induction (GO:0002645)3.83302158
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.78513582
27regulation of natural killer cell mediated immunity (GO:0002715)3.78513582
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.77739521
29negative T cell selection (GO:0043383)3.73633133
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.73425860
31immunoglobulin mediated immune response (GO:0016064)3.71307977
32regulation of tolerance induction (GO:0002643)3.69638384
33positive regulation of B cell differentiation (GO:0045579)3.63031168
34mast cell activation (GO:0045576)3.59904441
35antigen processing and presentation of endogenous antigen (GO:0019883)3.59207198
36positive thymic T cell selection (GO:0045059)3.58097800
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.56737083
38negative regulation of viral genome replication (GO:0045071)3.56718752
39negative thymic T cell selection (GO:0045060)3.55921574
40dendritic cell chemotaxis (GO:0002407)3.54296717
41regulation of lymphocyte chemotaxis (GO:1901623)3.52780842
42granulocyte activation (GO:0036230)3.52778675
43regulation of leukocyte mediated cytotoxicity (GO:0001910)3.49162209
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47954706
45regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45187487
46actin nucleation (GO:0045010)3.44135711
47regulation of alpha-beta T cell proliferation (GO:0046640)3.42704684
48neutrophil activation (GO:0042119)3.42461131
49B cell mediated immunity (GO:0019724)3.41646245
50regulation of B cell differentiation (GO:0045577)3.41164289
51neutrophil activation involved in immune response (GO:0002283)3.37836375
52lymphocyte chemotaxis (GO:0048247)3.34521288
53leukocyte aggregation (GO:0070486)3.31637098
54regulation of T cell mediated cytotoxicity (GO:0001914)3.30397655
55positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29322470
56regulation of interleukin-2 biosynthetic process (GO:0045076)3.27030604
57regulation of cell killing (GO:0031341)3.25237998
58positive regulation of calcium-mediated signaling (GO:0050850)3.24782136
59positive regulation of defense response to virus by host (GO:0002230)3.24742503
60positive regulation of cell killing (GO:0031343)3.23529469
61positive T cell selection (GO:0043368)3.22200374
62T cell costimulation (GO:0031295)3.20589196
63regulation of activation of Janus kinase activity (GO:0010533)3.19135952
64positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18133539
65regulation of T cell receptor signaling pathway (GO:0050856)3.17732186
66regulation of T cell chemotaxis (GO:0010819)3.17222398
67positive regulation of T cell chemotaxis (GO:0010820)3.17222398
68lymphocyte costimulation (GO:0031294)3.16027261
69leukocyte degranulation (GO:0043299)3.12060891
70positive regulation of lymphocyte migration (GO:2000403)3.11452003
71T cell selection (GO:0045058)3.10798235
72pyrimidine nucleoside catabolic process (GO:0046135)3.09599718
73antigen receptor-mediated signaling pathway (GO:0050851)3.08185453
74regulation of T cell apoptotic process (GO:0070232)3.08165201
75monocyte chemotaxis (GO:0002548)3.07552771
76B cell receptor signaling pathway (GO:0050853)3.06490327
77T cell receptor signaling pathway (GO:0050852)3.04952737
78dendritic cell migration (GO:0036336)3.03778133
79activated T cell proliferation (GO:0050798)3.03191028
80negative regulation of interleukin-12 production (GO:0032695)3.02106036
81eosinophil chemotaxis (GO:0048245)3.01962285
82cellular response to type I interferon (GO:0071357)2.99574507
83type I interferon signaling pathway (GO:0060337)2.99574507
84interferon-gamma production (GO:0032609)2.99270973
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98386397
86positive regulation of monocyte chemotaxis (GO:0090026)2.97524463
87natural killer cell differentiation (GO:0001779)2.96255092
88response to type I interferon (GO:0034340)2.95396295
89thymic T cell selection (GO:0045061)2.95070834
90positive regulation of interleukin-17 production (GO:0032740)2.94887648
91negative regulation of T cell mediated immunity (GO:0002710)2.92669799
92positive regulation of interleukin-2 production (GO:0032743)2.87977145
93interferon-gamma-mediated signaling pathway (GO:0060333)2.87508570
94mast cell activation involved in immune response (GO:0002279)2.86884446
95mast cell degranulation (GO:0043303)2.86884446
96positive regulation of lymphocyte mediated immunity (GO:0002708)2.84942842
97myeloid cell activation involved in immune response (GO:0002275)2.84425113
98positive regulation of macrophage differentiation (GO:0045651)2.84335643
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83728394
100regulation of lymphocyte migration (GO:2000401)2.83500616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.29734330
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.81380723
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.35848174
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.08651575
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.51340908
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.47947526
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.96721204
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19491547
9MYB_26560356_Chip-Seq_TH2_Human3.16297092
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14438497
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08696290
12RUNX_20019798_ChIP-Seq_JUKART_Human3.08428551
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.03003704
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.82653097
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.80388625
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79571311
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56213372
18GATA3_27048872_Chip-Seq_THYMUS_Human2.35034731
19MYB_26560356_Chip-Seq_TH1_Human2.34562126
20SPI1_23547873_ChIP-Seq_NB4_Human2.32621061
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23493853
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19278734
23MAF_26560356_Chip-Seq_TH1_Human2.13145931
24UTX_26944678_Chip-Seq_JUKART_Human2.11234034
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08405698
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07510287
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05471885
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99319895
29GATA3_26560356_Chip-Seq_TH2_Human1.97591071
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92768850
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91026496
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81292352
33SCL_19346495_ChIP-Seq_HPC-7_Human1.79745613
34MAF_26560356_Chip-Seq_TH2_Human1.78803665
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78705794
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76358077
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71442261
38SPI1_23127762_ChIP-Seq_K562_Human1.68008246
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65211096
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.64998158
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63719372
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58281165
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.56508537
44VDR_24763502_ChIP-Seq_THP-1_Human1.56141980
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55785004
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51384173
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.42185414
48MYC_22102868_ChIP-Seq_BL_Human1.28739558
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26539636
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25875661
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25513651
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19365193
53VDR_24787735_ChIP-Seq_THP-1_Human1.18311749
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11566513
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11080096
56PU_27001747_Chip-Seq_BMDM_Mouse1.09394264
57VDR_21846776_ChIP-Seq_THP-1_Human1.08673273
58VDR_23849224_ChIP-Seq_CD4+_Human1.07886903
59GATA1_22025678_ChIP-Seq_K562_Human1.07707005
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02169190
61BCL6_27268052_Chip-Seq_Bcells_Human1.00428079
62GATA1_19941827_ChIP-Seq_MEL_Mouse0.99057077
63HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98974973
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98449748
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98338747
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98204169
67FOXP3_21729870_ChIP-Seq_TREG_Human0.98203351
68CIITA_25753668_ChIP-Seq_RAJI_Human0.97635409
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96650342
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95445818
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93948968
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92498716
73EGR1_19374776_ChIP-ChIP_THP-1_Human0.91971073
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91251713
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90747395
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90515015
77GATA3_26560356_Chip-Seq_TH1_Human0.89219965
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88248651
79SPI1_20517297_ChIP-Seq_HL60_Human0.80664316
80BCOR_27268052_Chip-Seq_Bcells_Human0.79471541
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79299131
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78844421
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77934431
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77650203
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77342813
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.77296758
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.75130132
88STAT1_20625510_ChIP-Seq_HELA_Human0.72646982
89GATA1_19941826_ChIP-Seq_K562_Human0.72179893
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71954776
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71025750
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70019948
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69790935
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69785950
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69246658
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68324400
97GABP_17652178_ChIP-ChIP_JURKAT_Human0.67734297
98SMRT_27268052_Chip-Seq_Bcells_Human0.67386939
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.66686322
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.65860607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.84676528
2MP0001835_abnormal_antigen_presentation3.96750858
3MP0002148_abnormal_hypersensitivity_rea3.47670217
4MP0009785_altered_susceptibility_to3.42805400
5MP0005000_abnormal_immune_tolerance3.34859240
6MP0003436_decreased_susceptibility_to3.30131792
7MP0001800_abnormal_humoral_immune3.22036813
8MP0003724_increased_susceptibility_to3.14028556
9MP0003763_abnormal_thymus_physiology3.09184321
10MP0005387_immune_system_phenotype3.04440891
11MP0001790_abnormal_immune_system3.04440891
12MP0002723_abnormal_immune_serum2.81944330
13MP0000685_abnormal_immune_system2.78051499
14MP0005025_abnormal_response_to2.77524485
15MP0005464_abnormal_platelet_physiology2.74039602
16MP0002420_abnormal_adaptive_immunity2.63536268
17MP0002452_abnormal_antigen_presenting2.62527933
18MP0001819_abnormal_immune_cell2.58590979
19MP0006082_CNS_inflammation2.54934015
20MP0002419_abnormal_innate_immunity2.40931108
21MP0003303_peritoneal_inflammation2.34627763
22MP0009333_abnormal_splenocyte_physiolog2.15644973
23MP0002398_abnormal_bone_marrow2.15269287
24MP0002405_respiratory_system_inflammati2.11979847
25MP0000716_abnormal_immune_system2.04012941
26MP0010155_abnormal_intestine_physiology2.02268043
27MP0001845_abnormal_inflammatory_respons1.99465455
28MP0004947_skin_inflammation1.95603006
29MP0001853_heart_inflammation1.84929018
30MP0000689_abnormal_spleen_morphology1.84142667
31MP0002877_abnormal_melanocyte_morpholog1.81791303
32MP0001873_stomach_inflammation1.75508954
33MP0002722_abnormal_immune_system1.74509996
34MP0001533_abnormal_skeleton_physiology1.71215973
35MP0009764_decreased_sensitivity_to1.70821661
36MP0000703_abnormal_thymus_morphology1.63562801
37MP0002429_abnormal_blood_cell1.63096948
38MP0003866_abnormal_defecation1.62347065
39MP0002166_altered_tumor_susceptibility1.59799813
40MP0003300_gastrointestinal_ulcer1.53734458
41MP0003448_altered_tumor_morphology1.44991806
42MP0008469_abnormal_protein_level1.41850377
43MP0005058_abnormal_lysosome_morphology1.31288757
44MP0002006_tumorigenesis1.30774969
45MP0000858_altered_metastatic_potential1.30027206
46MP0003172_abnormal_lysosome_physiology1.27033461
47MP0004381_abnormal_hair_follicle1.24887761
48MP0008004_abnormal_stomach_pH1.24196850
49MP0000343_altered_response_to1.20391894
50MP0002998_abnormal_bone_remodeling1.20311537
51MP0002933_joint_inflammation1.19364563
52MP0005310_abnormal_salivary_gland1.18334737
53MP0003075_altered_response_to1.17785166
54MP0009763_increased_sensitivity_to1.11252757
55MP0002138_abnormal_hepatobiliary_system1.10301752
56MP0003183_abnormal_peptide_metabolism1.10056787
57MP0003191_abnormal_cellular_cholesterol1.07669826
58MP0000465_gastrointestinal_hemorrhage1.07668134
59MP0003045_fibrosis1.06910478
60MP0004510_myositis1.02857771
61MP0000569_abnormal_digit_pigmentation1.00970968
62MP0005166_decreased_susceptibility_to0.94847360
63MP0009278_abnormal_bone_marrow0.92435404
64MP0009765_abnormal_xenobiotic_induced0.91136552
65MP0000604_amyloidosis0.89832442
66MP0002277_abnormal_respiratory_mucosa0.88689759
67MP0005075_abnormal_melanosome_morpholog0.88022426
68MP0009840_abnormal_foam_cell0.85869357
69MP0002132_abnormal_respiratory_system0.81397807
70MP0002254_reproductive_system_inflammat0.79925003
71MP0005167_abnormal_blood-brain_barrier0.77510270
72MP0001851_eye_inflammation0.77038847
73MP0001663_abnormal_digestive_system0.76182204
74MP0000249_abnormal_blood_vessel0.72031991
75MP0002009_preneoplasia0.68238631
76MP0002019_abnormal_tumor_incidence0.66783848
77MP0002693_abnormal_pancreas_physiology0.65847243
78MP0005390_skeleton_phenotype0.62924005
79MP0008873_increased_physiological_sensi0.59258167
80MP0005397_hematopoietic_system_phenotyp0.59194168
81MP0001545_abnormal_hematopoietic_system0.59194168
82MP0003828_pulmonary_edema0.59025416
83MP0000490_abnormal_crypts_of0.57407600
84MP0002139_abnormal_hepatobiliary_system0.55625795
85MP0001501_abnormal_sleep_pattern0.55084956
86MP0003806_abnormal_nucleotide_metabolis0.54468305
87MP0002136_abnormal_kidney_physiology0.54048247
88MP0000920_abnormal_myelination0.52318770
89MP0003795_abnormal_bone_structure0.52246645
90MP0005164_abnormal_response_to0.49640329
91MP0005319_abnormal_enzyme/_coenzyme0.49380269
92MP0008874_decreased_physiological_sensi0.48269608
93MP0010307_abnormal_tumor_latency0.47953187
94MP0005174_abnormal_tail_pigmentation0.47370904
95MP0009643_abnormal_urine_homeostasis0.46431966
96MP0004036_abnormal_muscle_relaxation0.46398556
97MP0005379_endocrine/exocrine_gland_phen0.45117516
98MP0006035_abnormal_mitochondrial_morpho0.44829734
99MP0001727_abnormal_embryo_implantation0.44210710
100MP0002102_abnormal_ear_morphology0.42749860

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.51711072
2Abnormality of T cell number (HP:0011839)6.04931690
3Elevated erythrocyte sedimentation rate (HP:0003565)5.13373630
4Stomatitis (HP:0010280)5.11436142
5Increased IgM level (HP:0003496)5.00568857
6IgG deficiency (HP:0004315)4.71614789
7Severe combined immunodeficiency (HP:0004430)4.44662784
8Abnormality of T cells (HP:0002843)4.34146854
9Autoimmune hemolytic anemia (HP:0001890)4.27371576
10Abnormality of macrophages (HP:0004311)4.19780195
11Myositis (HP:0100614)4.05033834
12Chronic diarrhea (HP:0002028)3.94572779
13Combined immunodeficiency (HP:0005387)3.84734089
14Abnormality of eosinophils (HP:0001879)3.81721802
15Aplastic anemia (HP:0001915)3.78986490
16Recurrent bacterial skin infections (HP:0005406)3.78920772
17Recurrent viral infections (HP:0004429)3.78842787
18Optic neuritis (HP:0100653)3.67944439
19Retrobulbar optic neuritis (HP:0100654)3.67944439
20Abnormality of B cell number (HP:0010975)3.66024206
21Recurrent fungal infections (HP:0002841)3.64839213
22Recurrent abscess formation (HP:0002722)3.61355710
23Encephalitis (HP:0002383)3.58425947
24Meningitis (HP:0001287)3.57592051
25Orchitis (HP:0100796)3.47261095
26Leukocytosis (HP:0001974)3.44072599
27Vasculitis (HP:0002633)3.42602001
28Abnormality of liposaccharide metabolism (HP:0010968)3.42493371
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.42493371
30Abnormality of glycolipid metabolism (HP:0010969)3.42493371
31B lymphocytopenia (HP:0010976)3.41549849
32Thyroiditis (HP:0100646)3.40154555
33Eosinophilia (HP:0001880)3.36823165
34Obstructive lung disease (HP:0006536)3.36048106
35Chronic obstructive pulmonary disease (HP:0006510)3.36048106
36Pulmonary infiltrates (HP:0002113)3.34254678
37Abnormality of the prostate (HP:0008775)3.32089017
38Autoimmune thrombocytopenia (HP:0001973)3.31555100
39Recurrent bronchitis (HP:0002837)3.31291064
40Chronic mucocutaneous candidiasis (HP:0002728)3.29344803
41Recurrent cutaneous fungal infections (HP:0011370)3.29344803
42Petechiae (HP:0000967)3.23173307
43Eczematoid dermatitis (HP:0000976)3.20846761
44Mediastinal lymphadenopathy (HP:0100721)3.15837987
45Abnormal delayed hypersensitivity skin test (HP:0002963)3.14601467
46Granulocytopenia (HP:0001913)3.08282623
47Hypergammaglobulinemia (HP:0010702)3.01083997
48Hypoplasia of the thymus (HP:0000778)2.99691185
49Agammaglobulinemia (HP:0004432)2.95339927
50Recurrent skin infections (HP:0001581)2.95057480
51Joint swelling (HP:0001386)2.89808940
52Purpura (HP:0000979)2.88480043
53Pustule (HP:0200039)2.86893264
54Hypoproteinemia (HP:0003075)2.84869363
55Lymphopenia (HP:0001888)2.77978685
56Keratoconjunctivitis sicca (HP:0001097)2.73467268
57Abnormality of T cell physiology (HP:0011840)2.69314400
58Gangrene (HP:0100758)2.65830271
59IgM deficiency (HP:0002850)2.65502319
60Epistaxis (HP:0000421)2.65500627
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.63001356
62Hemoptysis (HP:0002105)2.61469854
63Keratoconjunctivitis (HP:0001096)2.54279693
64Pulmonary embolism (HP:0002204)2.51256527
65Lymphoma (HP:0002665)2.50528014
66Prolonged bleeding time (HP:0003010)2.49739093
67Panhypogammaglobulinemia (HP:0003139)2.49588201
68Spontaneous hematomas (HP:0007420)2.48264224
69IgA deficiency (HP:0002720)2.43570916
70Acute hepatic failure (HP:0006554)2.41311071
71Abnormality of the pleura (HP:0002103)2.32662586
72Polyneuropathy (HP:0001271)2.23140975
73Increased cerebral lipofuscin (HP:0011813)2.18205484
74Pulmonary fibrosis (HP:0002206)2.17487095
75Chest pain (HP:0100749)2.17254784
76Increased IgE level (HP:0003212)2.13720832
77Hepatosplenomegaly (HP:0001433)2.12126211
78Arterial thrombosis (HP:0004420)2.10746624
79Dysostosis multiplex (HP:0000943)2.09802856
80Urticaria (HP:0001025)2.08847307
81Vacuolated lymphocytes (HP:0001922)2.07674074
82Gastrointestinal infarctions (HP:0005244)2.07367767
83Aplasia/Hypoplasia of the thymus (HP:0010515)2.05587169
84Episodic fever (HP:0001954)2.04427270
85Glomerulopathy (HP:0100820)2.02167406
86Alveolar cell carcinoma (HP:0006519)2.01885925
87Gastrointestinal stroma tumor (HP:0100723)2.01011197
88Recurrent gram-negative bacterial infections (HP:0005420)2.00632940
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.97425993
90Anorexia (HP:0002039)1.95107166
91Gingival bleeding (HP:0000225)1.94480716
92Skin rash (HP:0000988)1.94385200
93Neoplasm of the tracheobronchial system (HP:0100552)1.87834107
94Progressive neurologic deterioration (HP:0002344)1.85795059
95Bronchitis (HP:0012387)1.85791346
96Increased serum ferritin (HP:0003281)1.84661597
97Papilledema (HP:0001085)1.84653873
98Arthralgia (HP:0002829)1.82426433
99Abnormality of male internal genitalia (HP:0000022)1.81810541
100Basal ganglia calcification (HP:0002135)1.80868029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.24154218
2MAP4K13.86291134
3RIPK43.22701911
4KDR2.82636059
5TAOK32.78452730
6FES2.73672517
7MST42.61933558
8TESK22.42555504
9GRK72.30865682
10MAP3K142.12717218
11IRAK42.04723989
12ZAP702.04715560
13CSK1.97542028
14SYK1.91232438
15IKBKB1.90059883
16TBK11.84278928
17MATK1.82428803
18BTK1.79331470
19TLK11.75160350
20BLK1.75090557
21IKBKE1.72601959
22ITK1.69481661
23BMPR21.58403397
24ADRBK21.57796169
25TNK21.52350923
26LCK1.45235053
27TEC1.42569138
28KIT1.42198442
29LYN1.39380912
30CSF1R1.37059770
31PRKCQ1.34597325
32JAK11.32139411
33PIK3CG1.26629492
34GRK61.22286411
35TESK11.19119718
36SIK31.18391521
37TYK21.18261046
38IRAK31.15170060
39MAPKAPK31.14564068
40JAK31.13520610
41HCK1.12899314
42ZAK1.09271755
43BCKDK0.99906396
44DAPK10.99775462
45MAP3K120.98746516
46ERN10.96774031
47MARK30.95876046
48JAK20.91350854
49FGR0.91300427
50STK100.89381671
51TAOK20.88640706
52MAP2K60.82903027
53SCYL20.79956798
54MAP2K30.79725565
55DAPK20.77787931
56PRPF4B0.74586982
57TGFBR20.73208835
58MAP3K30.73145728
59EIF2AK30.71568461
60PIM10.63981152
61MAPK70.63679570
62MYLK0.61904779
63PDK10.60933033
64TRIM280.59406721
65MAP3K50.58101339
66RPS6KA40.56693136
67FYN0.56663866
68MAPK120.55497931
69MAP3K130.53313984
70CHUK0.52186179
71CLK10.49806677
72MAP3K110.48307198
73GRK50.47499762
74EPHA30.47236578
75IRAK10.44655086
76TAF10.43501611
77MAPKAPK20.42253941
78PIM20.41756946
79NLK0.40920561
80IGF1R0.37899515
81MOS0.36913780
82PDGFRB0.36629073
83VRK10.33699015
84DAPK30.32911028
85TYRO30.32368696
86RPS6KA50.31604422
87ABL10.30672743
88PTK2B0.30560416
89INSR0.29101375
90MUSK0.28503479
91TRPM70.27464647
92MAPK110.26870987
93BMX0.25183483
94PRKCD0.25037537
95TAOK10.23514941
96MAP3K10.21707607
97EGFR0.19905418
98ACVR1B0.19820647
99IRAK20.18968451
100CDK40.17176880

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.10393999
2Graft-versus-host disease_Homo sapiens_hsa053323.40389977
3Allograft rejection_Homo sapiens_hsa053303.28899830
4Autoimmune thyroid disease_Homo sapiens_hsa053203.23879715
5Hematopoietic cell lineage_Homo sapiens_hsa046402.86406609
6Antigen processing and presentation_Homo sapiens_hsa046122.82245891
7T cell receptor signaling pathway_Homo sapiens_hsa046602.76555843
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.73478413
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67503048
10Type I diabetes mellitus_Homo sapiens_hsa049402.46799718
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.44308800
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.43474245
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.41068907
14Rheumatoid arthritis_Homo sapiens_hsa053232.38225181
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.34028967
16Measles_Homo sapiens_hsa051622.26960936
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13500091
18Leishmaniasis_Homo sapiens_hsa051402.11256414
19Asthma_Homo sapiens_hsa053102.06798989
20Osteoclast differentiation_Homo sapiens_hsa043802.03816809
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03040105
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.86052864
23Staphylococcus aureus infection_Homo sapiens_hsa051501.82094675
24Malaria_Homo sapiens_hsa051441.66150867
25Viral myocarditis_Homo sapiens_hsa054161.62722681
26TNF signaling pathway_Homo sapiens_hsa046681.54563959
27Herpes simplex infection_Homo sapiens_hsa051681.53490719
28Chemokine signaling pathway_Homo sapiens_hsa040621.44235293
29Salmonella infection_Homo sapiens_hsa051321.40240963
30Tuberculosis_Homo sapiens_hsa051521.39573377
31Legionellosis_Homo sapiens_hsa051341.38690677
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37129948
33Shigellosis_Homo sapiens_hsa051311.32406421
34B cell receptor signaling pathway_Homo sapiens_hsa046621.31068425
35Influenza A_Homo sapiens_hsa051641.23912080
36Proteasome_Homo sapiens_hsa030501.23127092
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19721567
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.19337588
39Pertussis_Homo sapiens_hsa051331.16859739
40Toxoplasmosis_Homo sapiens_hsa051451.05914078
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01300659
42Lysosome_Homo sapiens_hsa041420.94791477
43African trypanosomiasis_Homo sapiens_hsa051430.94070126
44Apoptosis_Homo sapiens_hsa042100.93434959
45Epstein-Barr virus infection_Homo sapiens_hsa051690.91036516
46Platelet activation_Homo sapiens_hsa046110.88032611
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84828362
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81675216
49Phagosome_Homo sapiens_hsa041450.75188518
50Systemic lupus erythematosus_Homo sapiens_hsa053220.74838101
51Hepatitis B_Homo sapiens_hsa051610.72882812
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72315195
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69520975
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.66368127
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59336342
56Viral carcinogenesis_Homo sapiens_hsa052030.58378393
57Hepatitis C_Homo sapiens_hsa051600.57465002
58HTLV-I infection_Homo sapiens_hsa051660.54713543
59Other glycan degradation_Homo sapiens_hsa005110.54282661
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51125846
61Collecting duct acid secretion_Homo sapiens_hsa049660.50163980
62Caffeine metabolism_Homo sapiens_hsa002320.45976522
63Acute myeloid leukemia_Homo sapiens_hsa052210.45600388
64Endocytosis_Homo sapiens_hsa041440.45022882
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44303508
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44065002
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.40919976
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38711197
69Regulation of autophagy_Homo sapiens_hsa041400.35974952
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.33693420
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33278573
72Sulfur metabolism_Homo sapiens_hsa009200.32836272
73Prion diseases_Homo sapiens_hsa050200.31836157
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30235740
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27005998
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.24027655
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20946322
78Oxidative phosphorylation_Homo sapiens_hsa001900.20731013
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20621286
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19649094
81Tryptophan metabolism_Homo sapiens_hsa003800.16463456
82Pancreatic cancer_Homo sapiens_hsa052120.15027192
83Parkinsons disease_Homo sapiens_hsa050120.14343430
84MAPK signaling pathway_Homo sapiens_hsa040100.14191295
85Non-small cell lung cancer_Homo sapiens_hsa052230.11842026
86Mineral absorption_Homo sapiens_hsa049780.11268096
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.09969441
88Arachidonic acid metabolism_Homo sapiens_hsa005900.04780242
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.02733818
90Prolactin signaling pathway_Homo sapiens_hsa049170.02715972
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02542553
92Insulin resistance_Homo sapiens_hsa049310.02095283
93VEGF signaling pathway_Homo sapiens_hsa043700.01134543
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00828187
95Olfactory transduction_Homo sapiens_hsa047400.00591126
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.00479216
97Phototransduction_Homo sapiens_hsa04744-0.0461763
98Amoebiasis_Homo sapiens_hsa05146-0.0441785
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0172879
100Nitrogen metabolism_Homo sapiens_hsa00910-0.0147207

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