TRGV5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of thymocyte apoptotic process (GO:0070244)6.81399420
2V(D)J recombination (GO:0033151)5.12466969
3cellular response to ethanol (GO:0071361)4.96888895
4positive regulation of gamma-delta T cell activation (GO:0046645)4.91888205
5neutrophil activation involved in immune response (GO:0002283)4.85093754
6negative regulation of cell killing (GO:0031342)4.70555594
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70555594
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48927005
9regulation of thymocyte apoptotic process (GO:0070243)4.29396247
10regulation of T-helper 1 cell differentiation (GO:0045625)4.24575391
11T cell lineage commitment (GO:0002360)4.20669806
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.12616049
13immunoglobulin mediated immune response (GO:0016064)4.11945331
14negative regulation of T cell apoptotic process (GO:0070233)4.09955283
15antigen processing and presentation of endogenous antigen (GO:0019883)4.02633017
16negative regulation of interleukin-12 production (GO:0032695)3.98592119
17regulation of B cell receptor signaling pathway (GO:0050855)3.91420187
18T cell migration (GO:0072678)3.90183463
19response to hydroperoxide (GO:0033194)3.88086771
20cellular extravasation (GO:0045123)3.85706958
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.83691300
22response to peptidoglycan (GO:0032494)3.83243149
23B cell proliferation (GO:0042100)3.80892057
24regulation of T-helper 2 cell differentiation (GO:0045628)3.75028072
25positive regulation of B cell differentiation (GO:0045579)3.73802281
26B cell receptor signaling pathway (GO:0050853)3.66442539
27detection of other organism (GO:0098543)3.62346102
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61269941
29B cell mediated immunity (GO:0019724)3.57892692
30cellular response to type I interferon (GO:0071357)3.53023902
31type I interferon signaling pathway (GO:0060337)3.53023902
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52239123
33detection of bacterium (GO:0016045)3.49680848
34response to type I interferon (GO:0034340)3.48680824
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.48562638
36negative regulation of T-helper cell differentiation (GO:0045623)3.48562638
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48548364
38T cell homeostasis (GO:0043029)3.44666181
39macrophage activation involved in immune response (GO:0002281)3.44657533
40myeloid cell activation involved in immune response (GO:0002275)3.44402075
41positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.42286372
42germinal center formation (GO:0002467)3.40955349
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40429326
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.40429326
45modulation by symbiont of host immune response (GO:0052553)3.40429326
46positive regulation by symbiont of host defense response (GO:0052509)3.40429326
47modulation by symbiont of host defense response (GO:0052031)3.40429326
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40429326
49neutrophil activation (GO:0042119)3.35159890
50granulocyte activation (GO:0036230)3.35032124
51regulation of gamma-delta T cell activation (GO:0046643)3.34806799
52positive regulation of type 2 immune response (GO:0002830)3.30317239
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24258949
54leukocyte aggregation (GO:0070486)3.16409722
55positive regulation of T-helper cell differentiation (GO:0045624)3.16122016
56regulation of antigen processing and presentation (GO:0002577)3.14106904
57leukocyte degranulation (GO:0043299)3.13099471
58interferon-gamma-mediated signaling pathway (GO:0060333)3.10417098
59positive thymic T cell selection (GO:0045059)3.09875792
60regulation of B cell differentiation (GO:0045577)3.09236918
61positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.06376211
62regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.06265890
63G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.06251698
64regulation of type 2 immune response (GO:0002828)3.05539764
65regulation of regulatory T cell differentiation (GO:0045589)3.04394655
66regulation of T cell apoptotic process (GO:0070232)3.01754517
67negative thymic T cell selection (GO:0045060)3.01382245
68mast cell activation (GO:0045576)3.00957624
69negative regulation of T cell mediated immunity (GO:0002710)3.00886579
70regulation of T-helper cell differentiation (GO:0045622)2.97644688
71T cell differentiation in thymus (GO:0033077)2.96950366
72lymphocyte homeostasis (GO:0002260)2.96566703
73negative regulation of type 2 immune response (GO:0002829)2.96466528
74positive regulation of antigen processing and presentation (GO:0002579)2.95444249
75negative T cell selection (GO:0043383)2.95222435
76negative regulation of lymphocyte apoptotic process (GO:0070229)2.93604195
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91866679
78regulation of interferon-beta biosynthetic process (GO:0045357)2.88478007
79regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.88350212
80regulation of interferon-alpha production (GO:0032647)2.84434912
81lymphocyte proliferation (GO:0046651)2.83874419
82detection of external biotic stimulus (GO:0098581)2.83708282
83mononuclear cell proliferation (GO:0032943)2.83141725
84regulation of mast cell activation (GO:0033003)2.82812928
85positive regulation of isotype switching (GO:0045830)2.82589989
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.82588738
87regulation of T cell tolerance induction (GO:0002664)2.82162090
88negative regulation of leukocyte apoptotic process (GO:2000107)2.80695532
89positive regulation of mast cell activation (GO:0033005)2.80512871
90interleukin-6-mediated signaling pathway (GO:0070102)2.80465220
91defense response to protozoan (GO:0042832)2.79811824
92regulation of gamma-delta T cell differentiation (GO:0045586)2.79496910
93regulation of mast cell degranulation (GO:0043304)2.77878788
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77666598
95adaptive immune response (GO:0002250)2.75901413
96regulation of vitamin D biosynthetic process (GO:0060556)2.75886159
97negative regulation of cytokine production involved in immune response (GO:0002719)2.74857091
98dendritic cell chemotaxis (GO:0002407)2.73836943
99regulation of alpha-beta T cell proliferation (GO:0046640)2.73169647
100activated T cell proliferation (GO:0050798)2.73119089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.43066128
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.63779925
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.63551520
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.55308800
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.15268622
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56706311
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44136678
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37571669
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.36295512
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32675017
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03633181
12RUNX_20019798_ChIP-Seq_JUKART_Human2.88045479
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82510943
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.81715663
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78699027
16MYB_26560356_Chip-Seq_TH2_Human2.66108859
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62783527
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61086755
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60194790
20VDR_24763502_ChIP-Seq_THP-1_Human2.48570415
21SPI1_23547873_ChIP-Seq_NB4_Human2.46727243
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46607302
23SCL_19346495_ChIP-Seq_HPC-7_Human2.46491695
24SPI1_23127762_ChIP-Seq_K562_Human2.44699347
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37439705
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.35793558
27MYC_22102868_ChIP-Seq_BL_Human2.33659543
28GATA1_22025678_ChIP-Seq_K562_Human2.27726526
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21200470
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18671907
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.16226369
32VDR_21846776_ChIP-Seq_THP-1_Human2.15993691
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15540907
34MYB_26560356_Chip-Seq_TH1_Human2.14604565
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09821899
36MAF_26560356_Chip-Seq_TH1_Human2.08895307
37UTX_26944678_Chip-Seq_JUKART_Human2.03788468
38GATA3_27048872_Chip-Seq_THYMUS_Human1.93257270
39VDR_24787735_ChIP-Seq_THP-1_Human1.90194310
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.87841541
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87364870
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85133614
43GATA2_22383799_ChIP-Seq_G1ME_Mouse1.72885186
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68981186
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.59453429
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57327389
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55959338
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53835535
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53217444
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50040224
51TCF7_22412390_ChIP-Seq_EML_Mouse1.48361222
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48318801
53MAF_26560356_Chip-Seq_TH2_Human1.45685680
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45601999
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41819569
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.41097106
57PU_27001747_Chip-Seq_BMDM_Mouse1.39653643
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38338101
59GATA1_19941826_ChIP-Seq_K562_Human1.35849291
60GATA3_26560356_Chip-Seq_TH2_Human1.34050525
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33158439
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33140671
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31682720
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25534460
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21213570
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21035680
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16279294
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14051151
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12980878
70KDM2B_26808549_Chip-Seq_DND41_Human1.12537523
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11253749
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10370920
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06522398
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04240712
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03804511
76GATA2_19941826_ChIP-Seq_K562_Human1.01825723
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01156366
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00534557
79GATA2_21666600_ChIP-Seq_HMVEC_Human0.99409670
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98682717
81NCOR1_26117541_ChIP-Seq_K562_Human0.98189799
82TFEB_21752829_ChIP-Seq_HELA_Human0.95976884
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95972304
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94941481
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92641064
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91781393
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.89378970
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88276346
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84627764
90ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82378895
91BCL6_27268052_Chip-Seq_Bcells_Human0.81087072
92SMRT_27268052_Chip-Seq_Bcells_Human0.80953915
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79770863
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.78823032
95BCOR_27268052_Chip-Seq_Bcells_Human0.76797485
96STAT1_20625510_ChIP-Seq_HELA_Human0.75577588
97CIITA_25753668_ChIP-Seq_RAJI_Human0.74654757
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74474940
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71752423
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69453625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.25432232
2MP0003303_peritoneal_inflammation3.94222714
3MP0009278_abnormal_bone_marrow3.92569991
4MP0005451_abnormal_body_composition3.92171453
5MP0005671_abnormal_response_to3.66597446
6MP0009785_altered_susceptibility_to3.46898458
7MP0002132_abnormal_respiratory_system3.42366600
8MP0003436_decreased_susceptibility_to3.25542665
9MP0003724_increased_susceptibility_to3.23383232
10MP0002148_abnormal_hypersensitivity_rea3.11618593
11MP0000685_abnormal_immune_system2.99820768
12MP0001790_abnormal_immune_system2.97684679
13MP0005387_immune_system_phenotype2.97684679
14MP0005000_abnormal_immune_tolerance2.90803622
15MP0001800_abnormal_humoral_immune2.90197613
16MP0004947_skin_inflammation2.83467046
17MP0005464_abnormal_platelet_physiology2.82308834
18MP0002419_abnormal_innate_immunity2.44794445
19MP0002452_abnormal_antigen_presenting2.43170417
20MP0002723_abnormal_immune_serum2.39541674
21MP0002166_altered_tumor_susceptibility2.38826130
22MP0005025_abnormal_response_to2.37973367
23MP0005397_hematopoietic_system_phenotyp2.34171200
24MP0001545_abnormal_hematopoietic_system2.34171200
25MP0010155_abnormal_intestine_physiology2.23555416
26MP0002420_abnormal_adaptive_immunity2.16459734
27MP0001819_abnormal_immune_cell2.14362978
28MP0006082_CNS_inflammation2.13983000
29MP0002398_abnormal_bone_marrow1.94760864
30MP0003763_abnormal_thymus_physiology1.93684155
31MP0002006_tumorigenesis1.89850717
32MP0005058_abnormal_lysosome_morphology1.87597497
33MP0003300_gastrointestinal_ulcer1.82136546
34MP0002876_abnormal_thyroid_physiology1.80899591
35MP0002405_respiratory_system_inflammati1.78015330
36MP0000716_abnormal_immune_system1.77378725
37MP0001845_abnormal_inflammatory_respons1.63034027
38MP0001533_abnormal_skeleton_physiology1.60855624
39MP0001849_ear_inflammation1.56932299
40MP0000689_abnormal_spleen_morphology1.55347448
41MP0002722_abnormal_immune_system1.53134161
42MP0003172_abnormal_lysosome_physiology1.48225690
43MP0002429_abnormal_blood_cell1.44762390
44MP0009764_decreased_sensitivity_to1.43688944
45MP0002998_abnormal_bone_remodeling1.39574336
46MP0008004_abnormal_stomach_pH1.38444304
47MP0000703_abnormal_thymus_morphology1.35741558
48MP0002933_joint_inflammation1.32855476
49MP0004510_myositis1.32085851
50MP0009333_abnormal_splenocyte_physiolog1.31575641
51MP0008469_abnormal_protein_level1.25176475
52MP0000343_altered_response_to1.14738815
53MP0001853_heart_inflammation1.11847669
54MP0003828_pulmonary_edema1.11431347
55MP0002396_abnormal_hematopoietic_system1.10106397
56MP0004808_abnormal_hematopoietic_stem1.05713330
57MP0000490_abnormal_crypts_of1.03695810
58MP0001663_abnormal_digestive_system1.03551772
59MP0003075_altered_response_to1.01525681
60MP0000465_gastrointestinal_hemorrhage0.97972056
61MP0000604_amyloidosis0.93123674
62MP0010094_abnormal_chromosome_stability0.92817227
63MP0000858_altered_metastatic_potential0.91080607
64MP0005310_abnormal_salivary_gland0.89197991
65MP0009840_abnormal_foam_cell0.89031347
66MP0003448_altered_tumor_morphology0.88288448
67MP0001879_abnormal_lymphatic_vessel0.84992550
68MP0003656_abnormal_erythrocyte_physiolo0.83769512
69MP0000249_abnormal_blood_vessel0.78087740
70MP0002009_preneoplasia0.77513193
71MP0003191_abnormal_cellular_cholesterol0.77359889
72MP0009763_increased_sensitivity_to0.76973054
73MP0002332_abnormal_exercise_endurance0.75836091
74MP0005167_abnormal_blood-brain_barrier0.74021800
75MP0008260_abnormal_autophagy0.72345259
76MP0005166_decreased_susceptibility_to0.72080623
77MP0001851_eye_inflammation0.72054087
78MP0003183_abnormal_peptide_metabolism0.69812206
79MP0002095_abnormal_skin_pigmentation0.68620306
80MP0003866_abnormal_defecation0.66491025
81MP0009765_abnormal_xenobiotic_induced0.65527924
82MP0002019_abnormal_tumor_incidence0.63231765
83MP0003795_abnormal_bone_structure0.62667930
84MP0003690_abnormal_glial_cell0.62501088
85MP0005381_digestive/alimentary_phenotyp0.60170128
86MP0005164_abnormal_response_to0.59957097
87MP0003091_abnormal_cell_migration0.59859929
88MP0005390_skeleton_phenotype0.57042279
89MP0003453_abnormal_keratinocyte_physiol0.56702582
90MP0004883_abnormal_blood_vessel0.56396723
91MP0004084_abnormal_cardiac_muscle0.53043347
92MP0008057_abnormal_DNA_replication0.52548032
93MP0003806_abnormal_nucleotide_metabolis0.49751617
94MP0002138_abnormal_hepatobiliary_system0.49412015
95MP0003045_fibrosis0.47130371
96MP0001191_abnormal_skin_condition0.45493789
97MP0001873_stomach_inflammation0.44142386
98MP0000920_abnormal_myelination0.44030500
99MP0001243_abnormal_dermal_layer0.41421663
100MP0000015_abnormal_ear_pigmentation0.40455873

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)9.13046018
2Panhypogammaglobulinemia (HP:0003139)8.47137740
3Hypoplasia of the thymus (HP:0000778)8.25637570
4Severe combined immunodeficiency (HP:0004430)8.04227448
5T lymphocytopenia (HP:0005403)7.02706807
6Combined immunodeficiency (HP:0005387)6.99806475
7Thyroiditis (HP:0100646)6.88353415
8Hypoproteinemia (HP:0003075)6.35030603
9Abnormality of T cell number (HP:0011839)6.08725240
10Eosinophilia (HP:0001880)5.77912049
11Granulocytopenia (HP:0001913)5.21586374
12Recurrent viral infections (HP:0004429)5.07561953
13Recurrent fungal infections (HP:0002841)4.58138301
14Abnormality of eosinophils (HP:0001879)4.36191378
15Meningitis (HP:0001287)4.30460023
16Erythroderma (HP:0001019)3.95505653
17Agammaglobulinemia (HP:0004432)3.94624389
18IgG deficiency (HP:0004315)3.94034405
19Leukocytosis (HP:0001974)3.92118835
20Abnormality of T cells (HP:0002843)3.65849835
21Aplasia/Hypoplasia of the thymus (HP:0010515)3.52487405
22Stomatitis (HP:0010280)3.36460827
23Recurrent bacterial skin infections (HP:0005406)3.31361206
24Recurrent abscess formation (HP:0002722)3.28905815
25Sepsis (HP:0100806)3.20597110
26Abnormality of macrophages (HP:0004311)3.18572510
27Myositis (HP:0100614)3.12698514
28Retrobulbar optic neuritis (HP:0100654)3.12330792
29Optic neuritis (HP:0100653)3.12330792
30Eczematoid dermatitis (HP:0000976)3.09109024
31Abnormality of glycolipid metabolism (HP:0010969)3.08431407
32Abnormality of liposaccharide metabolism (HP:0010968)3.08431407
33Abnormality of glycosphingolipid metabolism (HP:0004343)3.08431407
34Orchitis (HP:0100796)3.05461417
35Prolonged bleeding time (HP:0003010)2.94699501
36Cellulitis (HP:0100658)2.91300928
37Purpura (HP:0000979)2.78624526
38Spontaneous hematomas (HP:0007420)2.78040475
39Petechiae (HP:0000967)2.75203982
40Abnormality of the thymus (HP:0000777)2.73178533
41Encephalitis (HP:0002383)2.59232968
42Keratoconjunctivitis sicca (HP:0001097)2.58437328
43Recurrent bronchitis (HP:0002837)2.55959087
44Elevated erythrocyte sedimentation rate (HP:0003565)2.52414244
45Autoimmune hemolytic anemia (HP:0001890)2.48011212
46Epistaxis (HP:0000421)2.45556732
47Chronic sinusitis (HP:0011109)2.40641560
48Mediastinal lymphadenopathy (HP:0100721)2.35354214
49Keratoconjunctivitis (HP:0001096)2.35175081
50Obstructive lung disease (HP:0006536)2.31874921
51Chronic obstructive pulmonary disease (HP:0006510)2.31874921
52Vasculitis (HP:0002633)2.25339748
53Increased cerebral lipofuscin (HP:0011813)2.24352044
54Abnormal platelet volume (HP:0011876)2.22718853
55Dysostosis multiplex (HP:0000943)2.21216596
56Vacuolated lymphocytes (HP:0001922)2.21105861
57Lymphoma (HP:0002665)2.19801771
58Increased IgM level (HP:0003496)2.18439641
59Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15238556
60Gingival bleeding (HP:0000225)2.10462950
61Recurrent gram-negative bacterial infections (HP:0005420)2.08570764
62Recurrent skin infections (HP:0001581)2.08163071
63Osteomyelitis (HP:0002754)2.05896363
64Verrucae (HP:0200043)2.05005326
65Papilloma (HP:0012740)2.05005326
66Recurrent pneumonia (HP:0006532)2.03480465
67Autoimmune thrombocytopenia (HP:0001973)2.03073523
68B lymphocytopenia (HP:0010976)10.0047425
69Hematochezia (HP:0002573)1.99560516
70Increased mean platelet volume (HP:0011877)1.98898292
71Gastrointestinal infarctions (HP:0005244)1.95575563
72Pulmonary infiltrates (HP:0002113)1.91977996
73Increased IgE level (HP:0003212)1.91667896
74Conjunctival telangiectasia (HP:0000524)1.91353857
75Increased neuronal autofluorescent lipopigment (HP:0002074)1.88951741
76Abnormality of the prostate (HP:0008775)1.85960356
77Arterial thrombosis (HP:0004420)1.85706998
78Loss of speech (HP:0002371)1.85698418
79Abnormal delayed hypersensitivity skin test (HP:0002963)1.81800589
80Hemoptysis (HP:0002105)1.79885925
81Hepatosplenomegaly (HP:0001433)1.76101534
82Pulmonary embolism (HP:0002204)1.72211947
83Menorrhagia (HP:0000132)1.68000394
84Chronic mucocutaneous candidiasis (HP:0002728)1.67725614
85Recurrent cutaneous fungal infections (HP:0011370)1.67725614
86Hypergammaglobulinemia (HP:0010702)1.66410798
87Inflammation of the large intestine (HP:0002037)1.64197830
88Chronic diarrhea (HP:0002028)1.62759561
89Gangrene (HP:0100758)1.62707043
90Acute lymphatic leukemia (HP:0006721)1.60916308
91Urticaria (HP:0001025)1.57645319
92Gastrointestinal inflammation (HP:0004386)1.54655732
93Chest pain (HP:0100749)1.54148461
94Acute hepatic failure (HP:0006554)1.53985578
95Chronic otitis media (HP:0000389)1.53829047
96Colitis (HP:0002583)1.53707198
97Recurrent lower respiratory tract infections (HP:0002783)1.52206861
98Amaurosis fugax (HP:0100576)1.52181222
99Lymphopenia (HP:0001888)1.51251587
100Pruritus (HP:0000989)1.50942433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.26198143
2MAP4K13.31564419
3MAP3K143.19561760
4MAP3K133.06466149
5TAOK32.63026613
6BLK2.47917747
7TXK2.38918274
8TYK22.31822921
9IRAK42.23123143
10ERN12.20886476
11FES2.18260815
12BTK2.16567197
13PIK3CG2.12776820
14SYK2.05925504
15MAP2K32.04533157
16CSF1R1.90993088
17PRPF4B1.89842085
18CSK1.84613377
19ZAP701.83105713
20IRAK31.79671091
21SIK31.72409662
22TBK11.71779030
23IKBKB1.69319901
24GRK71.68190416
25KIT1.66680423
26TAOK21.66174331
27LYN1.62364533
28IKBKE1.62067924
29TEC1.59030140
30EIF2AK31.54309407
31MARK31.52153731
32TAOK11.51992538
33MAP3K31.51611098
34MATK1.47450975
35HCK1.47335339
36JAK31.46365876
37BMPR21.42975436
38FGR1.38583895
39JAK11.34404931
40LCK1.25025507
41NLK1.24541198
42GRK61.24339357
43TGFBR21.20848479
44ITK1.20747801
45MAP3K111.19891884
46TNK21.15375014
47MAP3K101.15338109
48STK101.10982903
49JAK21.09938593
50PIM21.07100834
51CLK10.99746875
52PIM10.98274143
53TYRO30.91756296
54FLT30.87746898
55MAP3K50.82907276
56MAP3K10.80440138
57MAPKAPK30.80004193
58IRAK10.77238526
59PDK10.76320719
60FGFR30.70501904
61CHUK0.68607495
62TESK20.68445939
63ADRBK20.67560445
64MAPK120.65114633
65MET0.64810095
66MARK20.64769203
67SCYL20.64756013
68MOS0.58924284
69MAPK40.56462492
70BMPR1B0.56304361
71CDC42BPA0.56039665
72RPS6KC10.55525153
73RPS6KL10.55525153
74TGFBR10.54779655
75IRAK20.54538711
76PRKCQ0.54205799
77HIPK20.52542742
78CAMKK20.51752737
79CDK60.50932959
80MAPK70.50744562
81YES10.50727169
82CDK40.50598090
83BMX0.49701597
84MAP3K70.48323261
85FYN0.45861720
86RPS6KB10.45312175
87SIK20.44609826
88RPS6KA60.44587150
89CDK120.44407173
90MAPK110.41900710
91MELK0.39215630
92PDPK10.39023810
93RET0.35434655
94STK110.33492265
95MAP3K80.32915673
96ABL10.32381462
97DYRK1B0.32278353
98CDK90.29329124
99PRKD20.29141941
100ARAF0.28458542

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.68949348
2Allograft rejection_Homo sapiens_hsa053302.87920297
3Graft-versus-host disease_Homo sapiens_hsa053322.78131242
4B cell receptor signaling pathway_Homo sapiens_hsa046622.59234404
5Autoimmune thyroid disease_Homo sapiens_hsa053202.53291447
6Leishmaniasis_Homo sapiens_hsa051402.45569561
7Osteoclast differentiation_Homo sapiens_hsa043802.44531417
8Hematopoietic cell lineage_Homo sapiens_hsa046402.37580901
9Asthma_Homo sapiens_hsa053102.31969056
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24484829
11Staphylococcus aureus infection_Homo sapiens_hsa051502.19018930
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.16775643
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.07868710
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05895989
15Non-homologous end-joining_Homo sapiens_hsa034502.02183902
16Type I diabetes mellitus_Homo sapiens_hsa049402.02135228
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84733540
18Other glycan degradation_Homo sapiens_hsa005111.83691567
19Antigen processing and presentation_Homo sapiens_hsa046121.82323674
20Malaria_Homo sapiens_hsa051441.78698524
21Tuberculosis_Homo sapiens_hsa051521.75999892
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73749885
23Measles_Homo sapiens_hsa051621.73359657
24Rheumatoid arthritis_Homo sapiens_hsa053231.66537150
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62423994
26Viral myocarditis_Homo sapiens_hsa054161.60574970
27Influenza A_Homo sapiens_hsa051641.59182802
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51864387
29T cell receptor signaling pathway_Homo sapiens_hsa046601.51192668
30Herpes simplex infection_Homo sapiens_hsa051681.50091975
31Legionellosis_Homo sapiens_hsa051341.48489081
32TNF signaling pathway_Homo sapiens_hsa046681.47413228
33Toxoplasmosis_Homo sapiens_hsa051451.46874267
34Acute myeloid leukemia_Homo sapiens_hsa052211.38234800
35Lysosome_Homo sapiens_hsa041421.35101343
36Chemokine signaling pathway_Homo sapiens_hsa040621.34469939
37Platelet activation_Homo sapiens_hsa046111.28908690
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25901049
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.25092497
40Pertussis_Homo sapiens_hsa051331.19794367
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19419686
42Hepatitis B_Homo sapiens_hsa051611.17283202
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16329238
44African trypanosomiasis_Homo sapiens_hsa051431.13333551
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11889262
46Hepatitis C_Homo sapiens_hsa051601.06677394
47Phagosome_Homo sapiens_hsa041451.06531800
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03109171
49Shigellosis_Homo sapiens_hsa051311.02237714
50FoxO signaling pathway_Homo sapiens_hsa040680.98685219
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.97952339
52Apoptosis_Homo sapiens_hsa042100.90572184
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87261445
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86870390
55Salmonella infection_Homo sapiens_hsa051320.85966862
56Epstein-Barr virus infection_Homo sapiens_hsa051690.84636099
57Pancreatic cancer_Homo sapiens_hsa052120.84092245
58Chronic myeloid leukemia_Homo sapiens_hsa052200.82488780
59HTLV-I infection_Homo sapiens_hsa051660.77929474
60Non-small cell lung cancer_Homo sapiens_hsa052230.74930912
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.72357759
62Caffeine metabolism_Homo sapiens_hsa002320.71319852
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66823902
64Renal cell carcinoma_Homo sapiens_hsa052110.65216603
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65126144
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.62760556
67Viral carcinogenesis_Homo sapiens_hsa052030.61719800
68Prolactin signaling pathway_Homo sapiens_hsa049170.61071377
69VEGF signaling pathway_Homo sapiens_hsa043700.59474290
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57364740
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56800688
72Collecting duct acid secretion_Homo sapiens_hsa049660.52116126
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.48417644
74Systemic lupus erythematosus_Homo sapiens_hsa053220.48008453
75Endocytosis_Homo sapiens_hsa041440.47505213
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46077955
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45741071
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.45467499
79mTOR signaling pathway_Homo sapiens_hsa041500.43914388
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43580524
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42256555
82Type II diabetes mellitus_Homo sapiens_hsa049300.41747350
83Amoebiasis_Homo sapiens_hsa051460.39788353
84Renin-angiotensin system_Homo sapiens_hsa046140.38969205
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37978003
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.34869037
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31164092
88Arachidonic acid metabolism_Homo sapiens_hsa005900.29581662
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28949792
90Notch signaling pathway_Homo sapiens_hsa043300.27733618
91Insulin resistance_Homo sapiens_hsa049310.27680163
92Prostate cancer_Homo sapiens_hsa052150.26647678
93ErbB signaling pathway_Homo sapiens_hsa040120.26603479
94Small cell lung cancer_Homo sapiens_hsa052220.25903185
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24446610
96HIF-1 signaling pathway_Homo sapiens_hsa040660.23822974
97MAPK signaling pathway_Homo sapiens_hsa040100.21966453
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20777831
99Bladder cancer_Homo sapiens_hsa052190.20170030
100Colorectal cancer_Homo sapiens_hsa052100.19449787

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