TRGV8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T cell migration (GO:0072678)7.44099680
2positive regulation of gamma-delta T cell activation (GO:0046645)6.55393133
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.38600254
4regulation of B cell receptor signaling pathway (GO:0050855)6.27745765
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79742313
6negative regulation of cell killing (GO:0031342)5.77091660
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.77091660
8negative T cell selection (GO:0043383)5.49839938
9lymphocyte chemotaxis (GO:0048247)5.09499577
10positive thymic T cell selection (GO:0045059)5.05672997
11positive T cell selection (GO:0043368)4.99768615
12negative thymic T cell selection (GO:0045060)4.90947288
13regulation of gamma-delta T cell differentiation (GO:0045586)4.77569138
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76604907
15cellular response to interleukin-15 (GO:0071350)4.69064156
16regulation of gamma-delta T cell activation (GO:0046643)4.67523617
17antigen processing and presentation of endogenous antigen (GO:0019883)4.67100916
18regulation of natural killer cell mediated immunity (GO:0002715)4.45149351
19regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.45149351
20response to interleukin-15 (GO:0070672)4.42531889
21Arp2/3 complex-mediated actin nucleation (GO:0034314)4.41931796
22regulation of T cell tolerance induction (GO:0002664)4.41504889
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41287923
24T cell selection (GO:0045058)4.39516301
25positive regulation of calcium-mediated signaling (GO:0050850)4.37121486
26thymic T cell selection (GO:0045061)4.36734561
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.31422055
28lymphocyte migration (GO:0072676)4.31312534
29positive regulation of natural killer cell mediated immunity (GO:0002717)4.26125760
30regulation of lymphocyte chemotaxis (GO:1901623)4.23644793
31leukocyte aggregation (GO:0070486)4.21597033
32negative regulation of execution phase of apoptosis (GO:1900118)4.19470617
33immunoglobulin mediated immune response (GO:0016064)4.15364741
34activated T cell proliferation (GO:0050798)4.10337484
35cytidine deamination (GO:0009972)4.05820253
36cytidine metabolic process (GO:0046087)4.05820253
37cytidine catabolic process (GO:0006216)4.05820253
38regulation of alpha-beta T cell proliferation (GO:0046640)4.05338938
39positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.04459172
40interferon-gamma production (GO:0032609)4.04097700
41positive regulation of alpha-beta T cell proliferation (GO:0046641)3.94270359
42regulation of B cell differentiation (GO:0045577)3.92367615
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.89467657
44regulation of tolerance induction (GO:0002643)3.89137551
45regulation of defense response to virus by virus (GO:0050690)3.84842883
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.82228292
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.77072718
48positive regulation of B cell differentiation (GO:0045579)3.76367825
49positive regulation of tolerance induction (GO:0002645)3.75506603
50T cell receptor signaling pathway (GO:0050852)3.74953363
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.73145658
52negative regulation of leukocyte mediated immunity (GO:0002704)3.72147549
53detection of other organism (GO:0098543)3.67007669
54pyrimidine ribonucleoside catabolic process (GO:0046133)3.62716253
55actin nucleation (GO:0045010)3.62544802
56negative regulation of interleukin-12 production (GO:0032695)3.62003537
57positive regulation of lymphocyte migration (GO:2000403)3.61091489
58chemokine-mediated signaling pathway (GO:0070098)3.59982506
59antigen receptor-mediated signaling pathway (GO:0050851)3.59625986
60detection of bacterium (GO:0016045)3.57889395
61positive regulation of T cell mediated cytotoxicity (GO:0001916)3.57196929
62respiratory burst (GO:0045730)3.54710572
63regulation of interleukin-2 biosynthetic process (GO:0045076)3.53515496
64B cell receptor signaling pathway (GO:0050853)3.53316894
65negative regulation of T cell mediated immunity (GO:0002710)3.50144637
66B cell mediated immunity (GO:0019724)3.46236248
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.45613341
68positive regulation of cell killing (GO:0031343)3.45219076
69positive regulation of monocyte chemotaxis (GO:0090026)3.44344022
70regulation of T cell mediated cytotoxicity (GO:0001914)3.43727629
71cellular defense response (GO:0006968)3.42295518
72regulation of calcium-mediated signaling (GO:0050848)3.42104248
73regulation of cell killing (GO:0031341)3.39943913
74cellular extravasation (GO:0045123)3.37391447
75DNA deamination (GO:0045006)3.37080511
76T cell costimulation (GO:0031295)3.33295196
77eosinophil chemotaxis (GO:0048245)3.31620899
78T cell mediated immunity (GO:0002456)3.31598395
79positive regulation of T cell chemotaxis (GO:0010820)3.31114030
80regulation of T cell chemotaxis (GO:0010819)3.31114030
81regulation of T cell receptor signaling pathway (GO:0050856)3.29318778
82lymphocyte costimulation (GO:0031294)3.28938190
83regulation of lymphocyte migration (GO:2000401)3.28236852
84neutrophil activation involved in immune response (GO:0002283)3.24338594
85antigen processing and presentation via MHC class Ib (GO:0002475)3.23551340
86mast cell activation (GO:0045576)3.22634123
87dendritic cell chemotaxis (GO:0002407)3.19183139
88granulocyte activation (GO:0036230)3.17594025
89macrophage activation involved in immune response (GO:0002281)3.17405895
90positive regulation of interleukin-2 production (GO:0032743)3.14081839
91neutrophil activation (GO:0042119)3.11931291
92myeloid cell activation involved in immune response (GO:0002275)3.11750248
93regulation of activation of Janus kinase activity (GO:0010533)3.11565023
94cellular response to type I interferon (GO:0071357)3.09100898
95type I interferon signaling pathway (GO:0060337)3.09100898
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08148552
97response to type I interferon (GO:0034340)3.07945321
98regulation of isotype switching to IgG isotypes (GO:0048302)3.06741563
99regulation of regulatory T cell differentiation (GO:0045589)3.06406794
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04556810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.55966632
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.91646800
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.80976778
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.09385782
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.36025853
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.99725566
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.59170075
8RUNX_20019798_ChIP-Seq_JUKART_Human3.52652660
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44295719
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14957860
11MYB_26560356_Chip-Seq_TH2_Human3.11580259
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.98532010
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78818551
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76739284
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74244273
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67405469
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.66813276
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50661585
19MYB_26560356_Chip-Seq_TH1_Human2.40520526
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40114455
21GATA3_27048872_Chip-Seq_THYMUS_Human2.37379070
22UTX_26944678_Chip-Seq_JUKART_Human2.35824799
23SPI1_23547873_ChIP-Seq_NB4_Human2.33458580
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.32777490
25MAF_26560356_Chip-Seq_TH1_Human2.28488827
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26520502
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98759202
28SCL_19346495_ChIP-Seq_HPC-7_Human1.97045564
29SPI1_23127762_ChIP-Seq_K562_Human1.90178016
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83826709
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.83672275
32VDR_24763502_ChIP-Seq_THP-1_Human1.83657469
33GATA3_26560356_Chip-Seq_TH2_Human1.82083078
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81431554
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79329434
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79243880
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78723303
38MAF_26560356_Chip-Seq_TH2_Human1.77483214
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56107799
40VDR_24787735_ChIP-Seq_THP-1_Human1.54846604
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53130865
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51812215
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50939302
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49319644
45VDR_21846776_ChIP-Seq_THP-1_Human1.48391847
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39191124
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.37442844
48MYC_22102868_ChIP-Seq_BL_Human1.30908602
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30598252
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24178278
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22658016
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20954884
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18914288
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18117806
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16767627
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13495442
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11194315
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07963204
59PU_27001747_Chip-Seq_BMDM_Mouse1.04174459
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03345299
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.01660059
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00307077
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99319648
64GATA1_22025678_ChIP-Seq_K562_Human0.98368173
65CIITA_25753668_ChIP-Seq_RAJI_Human0.96323504
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96049718
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95833801
68TCF7_22412390_ChIP-Seq_EML_Mouse0.94686467
69KDM2B_26808549_Chip-Seq_DND41_Human0.93440657
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93255852
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92925323
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90964204
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89992653
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88961164
75GATA3_26560356_Chip-Seq_TH1_Human0.88445795
76KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83020035
77BCL6_27268052_Chip-Seq_Bcells_Human0.82735606
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82510635
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82063710
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81352293
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77573936
82EGR1_19374776_ChIP-ChIP_THP-1_Human0.74537499
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.74429247
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74127386
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73906513
86BCOR_27268052_Chip-Seq_Bcells_Human0.73716701
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73290771
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73103805
89SPI1_20517297_ChIP-Seq_HL60_Human0.72235488
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71715073
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.71635704
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71083569
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70106835
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70036990
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68447267
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67796611
97GATA1_19941826_ChIP-Seq_K562_Human0.65132009
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63899500
99SMRT_27268052_Chip-Seq_Bcells_Human0.63112259
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.62645693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.91207696
2MP0001835_abnormal_antigen_presentation4.12813496
3MP0009785_altered_susceptibility_to3.93732095
4MP0003763_abnormal_thymus_physiology3.54464101
5MP0006082_CNS_inflammation3.47970838
6MP0003724_increased_susceptibility_to3.33837710
7MP0005025_abnormal_response_to3.15517272
8MP0001800_abnormal_humoral_immune3.14897099
9MP0005000_abnormal_immune_tolerance3.14209142
10MP0003436_decreased_susceptibility_to3.12341518
11MP0005387_immune_system_phenotype2.92386662
12MP0001790_abnormal_immune_system2.92386662
13MP0002420_abnormal_adaptive_immunity2.83366482
14MP0002723_abnormal_immune_serum2.82586815
15MP0001819_abnormal_immune_cell2.77975917
16MP0002419_abnormal_innate_immunity2.76397346
17MP0002148_abnormal_hypersensitivity_rea2.74765684
18MP0002452_abnormal_antigen_presenting2.66413121
19MP0000685_abnormal_immune_system2.62899530
20MP0009333_abnormal_splenocyte_physiolog2.43093587
21MP0002405_respiratory_system_inflammati2.29560652
22MP0003045_fibrosis2.25513002
23MP0002166_altered_tumor_susceptibility2.23606163
24MP0003866_abnormal_defecation2.16124090
25MP0002398_abnormal_bone_marrow2.12475204
26MP0000716_abnormal_immune_system2.08935893
27MP0003448_altered_tumor_morphology1.96552121
28MP0003300_gastrointestinal_ulcer1.89484185
29MP0003303_peritoneal_inflammation1.87972587
30MP0001845_abnormal_inflammatory_respons1.87788335
31MP0005464_abnormal_platelet_physiology1.86479865
32MP0010155_abnormal_intestine_physiology1.79619397
33MP0000703_abnormal_thymus_morphology1.76254632
34MP0000689_abnormal_spleen_morphology1.76075194
35MP0002722_abnormal_immune_system1.73109036
36MP0002006_tumorigenesis1.66358703
37MP0002429_abnormal_blood_cell1.59569533
38MP0004947_skin_inflammation1.57689817
39MP0004381_abnormal_hair_follicle1.57509814
40MP0008469_abnormal_protein_level1.56575853
41MP0001533_abnormal_skeleton_physiology1.55260335
42MP0003690_abnormal_glial_cell1.54643529
43MP0005058_abnormal_lysosome_morphology1.47805180
44MP0005166_decreased_susceptibility_to1.44265911
45MP0003172_abnormal_lysosome_physiology1.44164806
46MP0003191_abnormal_cellular_cholesterol1.42590204
47MP0003183_abnormal_peptide_metabolism1.37009265
48MP0002998_abnormal_bone_remodeling1.36082889
49MP0002132_abnormal_respiratory_system1.30956731
50MP0000858_altered_metastatic_potential1.28553110
51MP0005310_abnormal_salivary_gland1.27802531
52MP0004883_abnormal_blood_vessel1.22561711
53MP0009763_increased_sensitivity_to1.13038260
54MP0000604_amyloidosis1.09610772
55MP0000569_abnormal_digit_pigmentation1.09412815
56MP0000343_altered_response_to1.00864495
57MP0001851_eye_inflammation0.96131817
58MP0001853_heart_inflammation0.91482328
59MP0008260_abnormal_autophagy0.87799922
60MP0002277_abnormal_respiratory_mucosa0.86795794
61MP0009764_decreased_sensitivity_to0.85664342
62MP0002009_preneoplasia0.84456605
63MP0000920_abnormal_myelination0.84171435
64MP0000465_gastrointestinal_hemorrhage0.82870457
65MP0002168_other_aberrant_phenotype0.80946274
66MP0005075_abnormal_melanosome_morpholog0.80316809
67MP0005164_abnormal_response_to0.78279817
68MP0003828_pulmonary_edema0.75836505
69MP0003075_altered_response_to0.74884892
70MP0002396_abnormal_hematopoietic_system0.74258331
71MP0003806_abnormal_nucleotide_metabolis0.72518570
72MP0002019_abnormal_tumor_incidence0.71103385
73MP0002933_joint_inflammation0.67077683
74MP0003795_abnormal_bone_structure0.65933722
75MP0002693_abnormal_pancreas_physiology0.63879141
76MP0001542_abnormal_bone_strength0.61825995
77MP0005390_skeleton_phenotype0.60028975
78MP0004130_abnormal_muscle_cell0.59382683
79MP0006054_spinal_hemorrhage0.59220703
80MP0008873_increased_physiological_sensi0.57825685
81MP0001873_stomach_inflammation0.57396536
82MP0000490_abnormal_crypts_of0.57271399
83MP0009643_abnormal_urine_homeostasis0.56891240
84MP0003011_delayed_dark_adaptation0.55826611
85MP0000015_abnormal_ear_pigmentation0.53126556
86MP0005319_abnormal_enzyme/_coenzyme0.52869950
87MP0002138_abnormal_hepatobiliary_system0.51430396
88MP0004808_abnormal_hematopoietic_stem0.51004497
89MP0002136_abnormal_kidney_physiology0.49623185
90MP0000249_abnormal_blood_vessel0.47353546
91MP0009765_abnormal_xenobiotic_induced0.47208849
92MP0005379_endocrine/exocrine_gland_phen0.45742194
93MP0002102_abnormal_ear_morphology0.45634917
94MP0001919_abnormal_reproductive_system0.43887311
95MP0002163_abnormal_gland_morphology0.41928779
96MP0003329_amyloid_beta_deposits0.41456529
97MP0009840_abnormal_foam_cell0.40433280
98MP0005376_homeostasis/metabolism_phenot0.40341834
99MP0005451_abnormal_body_composition0.39953432
100MP0001663_abnormal_digestive_system0.39638569

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.13874184
2Abnormality of T cell number (HP:0011839)6.50944775
3Recurrent bacterial skin infections (HP:0005406)5.41654041
4Abnormality of macrophages (HP:0004311)5.06158570
5Recurrent abscess formation (HP:0002722)4.94971873
6Myositis (HP:0100614)4.64639776
7Eczematoid dermatitis (HP:0000976)4.63774911
8Stomatitis (HP:0010280)4.59571740
9Abnormality of T cells (HP:0002843)4.59437766
10Increased IgM level (HP:0003496)4.54920852
11Elevated erythrocyte sedimentation rate (HP:0003565)4.35959128
12Encephalitis (HP:0002383)4.32098362
13Optic neuritis (HP:0100653)4.13811621
14Retrobulbar optic neuritis (HP:0100654)4.13811621
15Orchitis (HP:0100796)4.05760153
16Recurrent cutaneous fungal infections (HP:0011370)4.04032359
17Chronic mucocutaneous candidiasis (HP:0002728)4.04032359
18IgG deficiency (HP:0004315)3.94312316
19Meningitis (HP:0001287)3.92593585
20Recurrent fungal infections (HP:0002841)3.90401143
21Recurrent skin infections (HP:0001581)3.86408905
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.78843406
23Gastrointestinal infarctions (HP:0005244)3.75986183
24Autoimmune hemolytic anemia (HP:0001890)3.74793737
25Recurrent viral infections (HP:0004429)3.69019908
26Mediastinal lymphadenopathy (HP:0100721)3.57027334
27Aplastic anemia (HP:0001915)3.53816513
28Severe combined immunodeficiency (HP:0004430)3.50245276
29Pustule (HP:0200039)3.44456206
30Chronic obstructive pulmonary disease (HP:0006510)3.36848299
31Obstructive lung disease (HP:0006536)3.36848299
32Recurrent gram-negative bacterial infections (HP:0005420)3.28402947
33Hypoproteinemia (HP:0003075)3.27481975
34Recurrent bronchitis (HP:0002837)3.25471319
35Leukocytosis (HP:0001974)3.20722408
36Spontaneous hematomas (HP:0007420)3.16762238
37Chronic diarrhea (HP:0002028)3.16370503
38Vasculitis (HP:0002633)3.15612403
39Pulmonary infiltrates (HP:0002113)3.15094036
40IgM deficiency (HP:0002850)3.11147166
41Acute hepatic failure (HP:0006554)3.03414149
42Combined immunodeficiency (HP:0005387)3.01447682
43Abnormality of eosinophils (HP:0001879)3.00162276
44Keratoconjunctivitis sicca (HP:0001097)2.96664649
45Chest pain (HP:0100749)2.93623715
46Panhypogammaglobulinemia (HP:0003139)2.90448576
47Eosinophilia (HP:0001880)2.82464545
48Lymphopenia (HP:0001888)2.77752096
49Inflammation of the large intestine (HP:0002037)2.76998588
50Hemoptysis (HP:0002105)2.73126393
51Keratoconjunctivitis (HP:0001096)2.70222200
52Hypergammaglobulinemia (HP:0010702)2.64029366
53Abnormality of the prostate (HP:0008775)2.62424811
54Granulocytopenia (HP:0001913)2.61788423
55Abnormality of liposaccharide metabolism (HP:0010968)2.61119855
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.61119855
57Abnormality of glycolipid metabolism (HP:0010969)2.61119855
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.61052212
59Arterial thrombosis (HP:0004420)2.60766075
60Thyroiditis (HP:0100646)2.55954366
61Gastrointestinal inflammation (HP:0004386)2.55524520
62Urticaria (HP:0001025)2.54771343
63Anorexia (HP:0002039)2.54766012
64Gingival bleeding (HP:0000225)2.52399553
65Agammaglobulinemia (HP:0004432)2.52186204
66Gingivitis (HP:0000230)2.49368862
67Pulmonary embolism (HP:0002204)2.47859385
68Autoimmune thrombocytopenia (HP:0001973)2.45849071
69Abnormality of T cell physiology (HP:0011840)2.42072015
70Broad face (HP:0000283)2.41783648
71Increased IgE level (HP:0003212)2.41687146
72Hypoplasia of the thymus (HP:0000778)2.41513848
73Gangrene (HP:0100758)2.41257866
74Joint swelling (HP:0001386)2.39846840
75Abnormality of the pleura (HP:0002103)2.39370994
76Epistaxis (HP:0000421)2.35174328
77Dysostosis multiplex (HP:0000943)2.26078311
78Lymphoma (HP:0002665)2.23816261
79Petechiae (HP:0000967)2.22507788
80Colitis (HP:0002583)2.15687686
81Abnormality of B cell number (HP:0010975)2.06585738
82Hemiplegia (HP:0002301)2.06387212
83Systemic lupus erythematosus (HP:0002725)2.04300655
84Polyneuropathy (HP:0001271)2.01850546
85Amaurosis fugax (HP:0100576)2.01244709
86Bronchitis (HP:0012387)2.00800492
87Glomerulopathy (HP:0100820)2.00436406
88Progressive neurologic deterioration (HP:0002344)1.91337445
89Amyotrophic lateral sclerosis (HP:0007354)1.90295513
90Hypochromic microcytic anemia (HP:0004840)1.90138110
91Increased serum ferritin (HP:0003281)1.89006127
92Prolonged bleeding time (HP:0003010)1.87605961
93B lymphocytopenia (HP:0010976)1.84937131
94Prostate neoplasm (HP:0100787)1.84674513
95Nasal polyposis (HP:0100582)1.83241563
96Acne (HP:0001061)1.81401298
97Purpura (HP:0000979)1.80329319
98Episodic fever (HP:0001954)1.79808347
99Skin ulcer (HP:0200042)1.78046752
100Hypochromic anemia (HP:0001931)1.77905924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.67977508
2TXK3.54054764
3KDR3.47721082
4RIPK43.41603302
5BLK3.33276861
6GRK73.01363889
7FES2.80246283
8CSK2.75978734
9TESK22.75961530
10TAOK32.65186115
11STK102.36747562
12TYK22.28056216
13BTK2.20652853
14ITK2.18671832
15TGFBR22.12001481
16ZAP702.05427433
17JAK31.99724348
18SYK1.94749034
19GRK61.91089850
20ERN11.88518136
21TEC1.72167699
22LCK1.70218597
23JAK11.60353310
24MAP3K111.58841715
25MOS1.57252992
26HCK1.57133120
27PRKCQ1.50168822
28MAP2K31.49522373
29LYN1.40770621
30TNK21.37055029
31IKBKE1.36424428
32MAP3K121.32734989
33TBK11.27037517
34IRAK41.24909273
35MAP3K141.20516471
36JAK21.18554362
37MAP3K31.16559702
38CSF1R1.14638231
39ADRBK21.14559137
40FGR1.10072085
41SCYL21.00843816
42MAP3K130.97948087
43BMPR20.97856044
44MARK30.97517314
45MAP3K50.94864277
46CAMKK20.93316069
47MAPK110.93040132
48PDK10.92896595
49PRPF4B0.90992810
50KIT0.88838245
51EPHB10.88239106
52PIK3CG0.87045937
53SIK30.82271954
54TAF10.80180880
55TAOK10.79802870
56FYN0.75868680
57CDK40.72107842
58IKBKB0.71913657
59GRK50.66503258
60TESK10.66464975
61MAP3K10.66269775
62TYRO30.65168961
63PIM10.63103694
64TAOK20.61026202
65NEK60.60815836
66PRKCH0.60731440
67MAPKAPK20.60483922
68TRPM70.51375633
69FGFR30.49648212
70SIK20.49220608
71LRRK20.47136341
72CLK10.46269553
73YES10.45830820
74NLK0.45704039
75INSR0.44553181
76CDK60.43470837
77MATK0.41699371
78EIF2AK30.40073761
79CDC42BPA0.39896235
80MAP3K70.38602259
81IGF1R0.37127012
82FGFR40.35951356
83NEK90.35839930
84PTK60.33969919
85PDGFRB0.33216081
86MAPKAPK30.33133909
87PTK2B0.31435747
88HIPK20.31060395
89ADRBK10.28966303
90CAMKK10.27236121
91ABL10.27096064
92CDK30.26836258
93MELK0.26797092
94MAPK120.26511199
95IRAK10.21723954
96PDPK10.19826400
97EGFR0.19612907
98MAP2K60.18636107
99PRKCD0.18583718
100NTRK20.18472561

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.67072788
2Graft-versus-host disease_Homo sapiens_hsa053323.64077090
3Antigen processing and presentation_Homo sapiens_hsa046123.54667969
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.11924862
5Allograft rejection_Homo sapiens_hsa053303.08638323
6T cell receptor signaling pathway_Homo sapiens_hsa046603.05867218
7Autoimmune thyroid disease_Homo sapiens_hsa053202.93829605
8Hematopoietic cell lineage_Homo sapiens_hsa046402.72196909
9Staphylococcus aureus infection_Homo sapiens_hsa051502.47064953
10Leishmaniasis_Homo sapiens_hsa051402.30175790
11Type I diabetes mellitus_Homo sapiens_hsa049402.28348328
12Measles_Homo sapiens_hsa051622.23828799
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.13740707
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11958661
15Osteoclast differentiation_Homo sapiens_hsa043802.10183728
16Viral myocarditis_Homo sapiens_hsa054161.98029628
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97869280
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.87531689
19Chemokine signaling pathway_Homo sapiens_hsa040621.81675663
20Malaria_Homo sapiens_hsa051441.81506053
21Asthma_Homo sapiens_hsa053101.80692874
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68610987
23B cell receptor signaling pathway_Homo sapiens_hsa046621.61365496
24Rheumatoid arthritis_Homo sapiens_hsa053231.59802765
25Tuberculosis_Homo sapiens_hsa051521.55406149
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50448020
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45662531
28Salmonella infection_Homo sapiens_hsa051321.45531086
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42162310
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33360561
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31633611
32Herpes simplex infection_Homo sapiens_hsa051681.25078348
33Influenza A_Homo sapiens_hsa051641.23918729
34Shigellosis_Homo sapiens_hsa051311.22891567
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17682248
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.16999599
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09258769
38Phagosome_Homo sapiens_hsa041451.06339561
39Toxoplasmosis_Homo sapiens_hsa051451.06240589
40Legionellosis_Homo sapiens_hsa051341.04099425
41Pertussis_Homo sapiens_hsa051331.02819700
42Platelet activation_Homo sapiens_hsa046111.01817379
43TNF signaling pathway_Homo sapiens_hsa046680.99917723
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96507872
45Apoptosis_Homo sapiens_hsa042100.92947171
46Lysosome_Homo sapiens_hsa041420.90874900
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.88095178
48Hepatitis B_Homo sapiens_hsa051610.75361350
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72940910
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.70246197
51African trypanosomiasis_Homo sapiens_hsa051430.69902832
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68507623
53HTLV-I infection_Homo sapiens_hsa051660.68293294
54Epstein-Barr virus infection_Homo sapiens_hsa051690.66154982
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.64978650
56Endocytosis_Homo sapiens_hsa041440.63537640
57Acute myeloid leukemia_Homo sapiens_hsa052210.59060041
58Hepatitis C_Homo sapiens_hsa051600.54490758
59Proteasome_Homo sapiens_hsa030500.53903208
60Non-small cell lung cancer_Homo sapiens_hsa052230.53436815
61VEGF signaling pathway_Homo sapiens_hsa043700.52505048
62Other glycan degradation_Homo sapiens_hsa005110.49747626
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45045147
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44950740
65Prion diseases_Homo sapiens_hsa050200.43717319
66Viral carcinogenesis_Homo sapiens_hsa052030.42513087
67Pancreatic cancer_Homo sapiens_hsa052120.42332368
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41192169
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40271342
70Regulation of autophagy_Homo sapiens_hsa041400.38460665
71Systemic lupus erythematosus_Homo sapiens_hsa053220.38309992
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30876079
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30431041
74Collecting duct acid secretion_Homo sapiens_hsa049660.29090393
75FoxO signaling pathway_Homo sapiens_hsa040680.26833607
76MAPK signaling pathway_Homo sapiens_hsa040100.26646903
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26499408
78Prolactin signaling pathway_Homo sapiens_hsa049170.25474248
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25456968
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24941704
81Notch signaling pathway_Homo sapiens_hsa043300.23739815
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.23317771
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22413926
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19820994
85Rap1 signaling pathway_Homo sapiens_hsa040150.17594510
86Chronic myeloid leukemia_Homo sapiens_hsa052200.16426557
87Renin secretion_Homo sapiens_hsa049240.15839882
88Insulin resistance_Homo sapiens_hsa049310.13396653
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.13047381
90Complement and coagulation cascades_Homo sapiens_hsa046100.11408435
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11122731
92Ras signaling pathway_Homo sapiens_hsa040140.10780945
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10682597
94Amoebiasis_Homo sapiens_hsa051460.10608855
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08141394
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07993448
97Caffeine metabolism_Homo sapiens_hsa002320.07368920
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07253768
99Colorectal cancer_Homo sapiens_hsa052100.07235511
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.07051101

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