TRGV9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)8.00010912
2positive regulation of transcription from RNA polymerase III promoter (GO:0045945)7.42872734
3piRNA metabolic process (GO:0034587)6.82341395
4negative regulation of cell killing (GO:0031342)5.86875713
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.86875713
6cellular response to interleukin-15 (GO:0071350)5.42307793
7negative T cell selection (GO:0043383)5.30310733
8negative regulation of stress fiber assembly (GO:0051497)5.15470185
9negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.11536730
10negative thymic T cell selection (GO:0045060)5.08974610
11positive regulation of macrophage cytokine production (GO:0060907)5.02139206
12prostate gland epithelium morphogenesis (GO:0060740)5.00189197
13regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.89117053
14DNA methylation involved in gamete generation (GO:0043046)4.84921175
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84525009
16positive thymic T cell selection (GO:0045059)4.77492962
17opsonization (GO:0008228)4.72840923
18artery development (GO:0060840)4.72120482
19positive T cell selection (GO:0043368)4.65924029
20biotin metabolic process (GO:0006768)4.54910849
21regulation of receptor binding (GO:1900120)4.54469207
22regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.47180350
23response to testosterone (GO:0033574)4.45323322
24response to interleukin-15 (GO:0070672)4.42807983
25positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.39614776
26regulation of B cell receptor signaling pathway (GO:0050855)4.36216953
27positive regulation of steroid hormone secretion (GO:2000833)4.29377933
28positive regulation of granulocyte differentiation (GO:0030854)4.28640228
29thymic T cell selection (GO:0045061)4.27214058
30mitotic cell cycle arrest (GO:0071850)4.04740063
31peptidyl-tyrosine autophosphorylation (GO:0038083)3.97944362
32positive regulation of gamma-delta T cell activation (GO:0046645)3.93519169
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.90299880
34regulation of natural killer cell mediated immunity (GO:0002715)3.90299880
35regulation of protein polyubiquitination (GO:1902914)3.89098969
36myeloid leukocyte mediated immunity (GO:0002444)3.88404468
37positive regulation of natural killer cell mediated immunity (GO:0002717)3.88241714
38sex differentiation (GO:0007548)3.79308141
39Golgi to endosome transport (GO:0006895)3.78135258
40regulation of transcription from RNA polymerase III promoter (GO:0006359)3.76198077
41epithelial cell maturation (GO:0002070)3.75085263
42negative regulation of actin filament bundle assembly (GO:0032232)3.74295981
43cytidine metabolic process (GO:0046087)3.72746410
44cytidine catabolic process (GO:0006216)3.72746410
45cytidine deamination (GO:0009972)3.72746410
46positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.72394669
47T cell selection (GO:0045058)3.72205360
48mitochondrion degradation (GO:0000422)3.71069342
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67139676
50positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.65832901
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.65269812
52regulation of gamma-delta T cell differentiation (GO:0045586)3.61132624
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.57927531
54DNA deamination (GO:0045006)3.54576121
55positive regulation of cell killing (GO:0031343)3.53453059
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.50644045
57negative regulation of DNA repair (GO:0045738)3.46718225
58regulation of leukocyte mediated cytotoxicity (GO:0001910)3.41451606
59histone H3-K4 trimethylation (GO:0080182)3.41048645
60regulation of cell killing (GO:0031341)3.39941193
61androgen receptor signaling pathway (GO:0030521)3.39700897
62activated T cell proliferation (GO:0050798)3.33313419
63regulation of ARF protein signal transduction (GO:0032012)3.26932685
64positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22865689
65prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.21485160
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19834489
67positive regulation of defense response to virus by host (GO:0002230)3.17735992
68adenosine metabolic process (GO:0046085)3.17118117
69regulation of gamma-delta T cell activation (GO:0046643)3.17056938
70negative regulation of T cell mediated immunity (GO:0002710)3.15470175
71regulation of regulatory T cell differentiation (GO:0045589)3.15301848
72regulation of T cell mediated cytotoxicity (GO:0001914)3.14537992
73adaptation of signaling pathway (GO:0023058)3.14451898
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.14095182
75alpha-beta T cell differentiation (GO:0046632)3.06305839
76positive regulation of fibroblast migration (GO:0010763)3.06256734
77T-helper cell differentiation (GO:0042093)3.06222908
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.06222908
79antigen processing and presentation of endogenous antigen (GO:0019883)3.03003345
80mast cell activation (GO:0045576)3.02035150
81regulation of RIG-I signaling pathway (GO:0039535)3.01935710
82regulation of macrophage cytokine production (GO:0010935)3.00904855
83positive regulation by host of viral transcription (GO:0043923)2.99777376
84leukocyte aggregation (GO:0070486)2.96886477
85positive regulation of T cell chemotaxis (GO:0010820)2.91961090
86regulation of T cell chemotaxis (GO:0010819)2.91961090
87regulation of alpha-beta T cell proliferation (GO:0046640)2.91651774
88antigen processing and presentation via MHC class Ib (GO:0002475)2.90511426
89cellular response to interleukin-4 (GO:0071353)2.90288723
90cellular response to nicotine (GO:0071316)2.87737328
91pharyngeal system development (GO:0060037)2.81062522
92gene silencing by RNA (GO:0031047)2.78101292
93positive regulation of cytokine production involved in immune response (GO:0002720)2.76858919
94alpha-beta T cell differentiation involved in immune response (GO:0002293)2.76693028
95alpha-beta T cell activation involved in immune response (GO:0002287)2.76693028
96T cell differentiation involved in immune response (GO:0002292)2.76693028
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.76625480
98positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.73839818
99CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.70329441
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69905929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.25124902
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49136243
3PIAS1_25552417_ChIP-Seq_VCAP_Human4.21790236
4FOXA1_25552417_ChIP-Seq_VCAP_Human3.09744993
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.06771273
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05282573
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99004158
8CIITA_25753668_ChIP-Seq_RAJI_Human2.92989786
9ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.84285680
10RUNX_20019798_ChIP-Seq_JUKART_Human2.77261912
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.55657195
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54117430
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.49894306
14MYC_22102868_ChIP-Seq_BL_Human2.47063824
15MYB_26560356_Chip-Seq_TH2_Human2.45895575
16ERG_20517297_ChIP-Seq_VCAP_Human2.42251249
17DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.37541651
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31503880
19UTX_26944678_Chip-Seq_JUKART_Human2.29001096
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18606524
21MYB_26560356_Chip-Seq_TH1_Human2.17431927
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09422887
23AR_21909140_ChIP-Seq_LNCAP_Human2.08027771
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.04089598
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01170289
26KDM5A_27292631_Chip-Seq_BREAST_Human1.97169176
27VDR_21846776_ChIP-Seq_THP-1_Human1.96429310
28CHD1_26751641_Chip-Seq_LNCaP_Human1.94253599
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.92735232
30TCF7_22412390_ChIP-Seq_EML_Mouse1.85901662
31MAF_26560356_Chip-Seq_TH1_Human1.84555686
32SCL_19346495_ChIP-Seq_HPC-7_Human1.82028303
33GATA3_27048872_Chip-Seq_THYMUS_Human1.80798339
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78331723
35SPI1_23547873_ChIP-Seq_NB4_Human1.76343845
36OCT1_27270436_Chip-Seq_PROSTATE_Human1.71273630
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70317375
38MAF_26560356_Chip-Seq_TH2_Human1.69791471
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.65748975
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.65107904
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.63138049
42SPI1_23127762_ChIP-Seq_K562_Human1.62506696
43EZH2_22144423_ChIP-Seq_EOC_Human1.61364459
44AR_21572438_ChIP-Seq_LNCaP_Human1.60564497
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59015687
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54880403
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54594586
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54430101
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.54195804
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.53130844
51ELF5_23300383_ChIP-Seq_T47D_Human1.51185757
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49085890
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46718164
54AR_20517297_ChIP-Seq_VCAP_Human1.45399213
55GATA3_26560356_Chip-Seq_TH2_Human1.43169568
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41918392
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40963887
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.40674039
59VDR_24763502_ChIP-Seq_THP-1_Human1.38800393
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.38679429
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34281445
62VDR_23849224_ChIP-Seq_CD4+_Human1.29769176
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.18149031
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16140353
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16057759
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13807348
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12702367
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12419920
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11614913
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08353864
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06883887
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02545782
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00841489
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00411231
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99230435
76FOXP3_21729870_ChIP-Seq_TREG_Human0.98743067
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98207913
78HTT_18923047_ChIP-ChIP_STHdh_Human0.97608864
79BCOR_27268052_Chip-Seq_Bcells_Human0.94205598
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93921707
81P68_20966046_ChIP-Seq_HELA_Human0.93411574
82KDM2B_26808549_Chip-Seq_DND41_Human0.93145415
83STAT1_20625510_ChIP-Seq_HELA_Human0.92415777
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91931791
85SMC4_20622854_ChIP-Seq_HELA_Human0.91236930
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90094148
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88671208
88P300_27268052_Chip-Seq_Bcells_Human0.88590644
89CREB1_26743006_Chip-Seq_LNCaP_Human0.88375774
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87750298
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87577234
92BCL6_27268052_Chip-Seq_Bcells_Human0.86783702
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.84785778
94SMRT_27268052_Chip-Seq_Bcells_Human0.84113656
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83276051
96DROSHA_22980978_ChIP-Seq_HELA_Human0.82848921
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82731146
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82649575
99MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82635267
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.82533172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia8.24438062
2MP0000537_abnormal_urethra_morphology7.17817212
3MP0002166_altered_tumor_susceptibility5.92307227
4MP0003315_abnormal_perineum_morphology5.50363497
5MP0004145_abnormal_muscle_electrophysio4.75483178
6MP0002006_tumorigenesis4.34133399
7MP0005310_abnormal_salivary_gland3.38514399
8MP0002234_abnormal_pharynx_morphology3.10787897
9MP0005645_abnormal_hypothalamus_physiol2.66289968
10MP0005671_abnormal_response_to2.55708680
11MP0000516_abnormal_urinary_system2.49878921
12MP0005367_renal/urinary_system_phenotyp2.49878921
13MP0000538_abnormal_urinary_bladder2.23021143
14MP0003763_abnormal_thymus_physiology2.16526142
15MP0001873_stomach_inflammation2.12706232
16MP0001919_abnormal_reproductive_system2.00584517
17MP0005451_abnormal_body_composition1.84533103
18MP0008961_abnormal_basal_metabolism1.83743084
19MP0001835_abnormal_antigen_presentation1.76263983
20MP0003283_abnormal_digestive_organ1.60902724
21MP0004185_abnormal_adipocyte_glucose1.44961579
22MP0005647_abnormal_sex_gland1.38022790
23MP0005387_immune_system_phenotype1.29858182
24MP0001790_abnormal_immune_system1.29858182
25MP0001800_abnormal_humoral_immune1.29111899
26MP0005075_abnormal_melanosome_morpholog1.27136108
27MP0005000_abnormal_immune_tolerance1.25800916
28MP0002822_catalepsy1.25787195
29MP0003724_increased_susceptibility_to1.23791944
30MP0005187_abnormal_penis_morphology1.18640318
31MP0002723_abnormal_immune_serum1.17910860
32MP0004381_abnormal_hair_follicle1.15457923
33MP0002420_abnormal_adaptive_immunity1.14086475
34MP0002398_abnormal_bone_marrow1.13510314
35MP0000703_abnormal_thymus_morphology1.12987477
36MP0001819_abnormal_immune_cell1.12310513
37MP0000685_abnormal_immune_system1.09151883
38MP0005025_abnormal_response_to1.09134148
39MP0006082_CNS_inflammation1.07370709
40MP0001348_abnormal_lacrimal_gland1.06999829
41MP0002909_abnormal_adrenal_gland1.03241765
42MP0002405_respiratory_system_inflammati1.02991755
43MP0002277_abnormal_respiratory_mucosa1.01382102
44MP0004858_abnormal_nervous_system1.00382223
45MP0004036_abnormal_muscle_relaxation0.99817166
46MP0000716_abnormal_immune_system0.97688890
47MP0002693_abnormal_pancreas_physiology0.96504882
48MP0002452_abnormal_antigen_presenting0.94494111
49MP0003866_abnormal_defecation0.94426375
50MP0006276_abnormal_autonomic_nervous0.92283257
51MP0003436_decreased_susceptibility_to0.91842686
52MP0003045_fibrosis0.90540634
53MP0002722_abnormal_immune_system0.87348974
54MP0005646_abnormal_pituitary_gland0.86060255
55MP0002876_abnormal_thyroid_physiology0.85958244
56MP0002396_abnormal_hematopoietic_system0.85794726
57MP0003787_abnormal_imprinting0.85234163
58MP0002148_abnormal_hypersensitivity_rea0.84954817
59MP0000689_abnormal_spleen_morphology0.84224328
60MP0003879_abnormal_hair_cell0.76855952
61MP0003448_altered_tumor_morphology0.74464879
62MP0009333_abnormal_splenocyte_physiolog0.73804734
63MP0004947_skin_inflammation0.72956615
64MP0002429_abnormal_blood_cell0.72151123
65MP0001853_heart_inflammation0.70981215
66MP0009785_altered_susceptibility_to0.69746037
67MP0010155_abnormal_intestine_physiology0.66600351
68MP0002638_abnormal_pupillary_reflex0.65546513
69MP0005076_abnormal_cell_differentiation0.65517509
70MP0002419_abnormal_innate_immunity0.65031489
71MP0005167_abnormal_blood-brain_barrier0.63992097
72MP0002735_abnormal_chemical_nociception0.63933072
73MP0000747_muscle_weakness0.62891359
74MP0001845_abnormal_inflammatory_respons0.62230851
75MP0005220_abnormal_exocrine_pancreas0.59088981
76MP0005666_abnormal_adipose_tissue0.57326279
77MP0005448_abnormal_energy_balance0.57235989
78MP0000627_abnormal_mammary_gland0.57087543
79MP0001501_abnormal_sleep_pattern0.56822157
80MP0001765_abnormal_ion_homeostasis0.56610719
81MP0000920_abnormal_myelination0.54952942
82MP0004510_myositis0.53750885
83MP0002019_abnormal_tumor_incidence0.51091832
84MP0003011_delayed_dark_adaptation0.50720591
85MP0000613_abnormal_salivary_gland0.49991840
86MP0005464_abnormal_platelet_physiology0.49956396
87MP0001764_abnormal_homeostasis0.48668545
88MP0004808_abnormal_hematopoietic_stem0.47442052
89MP0003705_abnormal_hypodermis_morpholog0.45228461
90MP0001664_abnormal_digestion0.44047741
91MP0009053_abnormal_anal_canal0.43697365
92MP0001944_abnormal_pancreas_morphology0.43644128
93MP0002653_abnormal_ependyma_morphology0.43065674
94MP0002160_abnormal_reproductive_system0.42788280
95MP0010234_abnormal_vibrissa_follicle0.42254306
96MP0008469_abnormal_protein_level0.41570752
97MP0005636_abnormal_mineral_homeostasis0.40880223
98MP0002163_abnormal_gland_morphology0.39942745
99MP0001145_abnormal_male_reproductive0.38767976
100MP0003303_peritoneal_inflammation0.37838508

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)9.13132486
2Prostate neoplasm (HP:0100787)8.52554234
3Abnormality of the axillary hair (HP:0100134)7.51485453
4Abnormality of secondary sexual hair (HP:0009888)7.51485453
5Calf muscle hypertrophy (HP:0008981)7.42591337
6Gonadotropin excess (HP:0000837)6.87805168
7Muscle hypertrophy of the lower extremities (HP:0008968)6.53334955
8Abnormality of the prostate (HP:0008775)5.64817322
9Azoospermia (HP:0000027)5.23237659
10Abnormality of the 1st metacarpal (HP:0010009)5.11346227
11Short 1st metacarpal (HP:0010034)4.88206675
12Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.88206675
13Abnormal tarsal ossification (HP:0008369)4.63410359
14Abnormal spermatogenesis (HP:0008669)4.62517529
15T lymphocytopenia (HP:0005403)4.43891475
16Abnormality of T cell number (HP:0011839)4.32305334
17Testicular neoplasm (HP:0010788)4.19086288
18Septate vagina (HP:0001153)3.99091130
19Short phalanx of the thumb (HP:0009660)3.88894694
20Abnormality of carpal bone ossification (HP:0006257)3.79080143
21Abnormal foot bone ossification (HP:0010675)3.67302067
22Abnormality of male internal genitalia (HP:0000022)3.63083872
23Autoimmune hemolytic anemia (HP:0001890)3.26070124
24Ureteral stenosis (HP:0000071)3.21508168
25Bifid scrotum (HP:0000048)3.19946171
26Abnormal hand bone ossification (HP:0010660)3.12256749
27Bulbar palsy (HP:0001283)3.10906640
28Hyperpituitarism (HP:0010514)3.08526876
29Ureteral obstruction (HP:0006000)3.07277844
30Abnormality of T cells (HP:0002843)3.00139605
31Abnormal ossification of hand bones (HP:0005921)2.90599242
32Severe combined immunodeficiency (HP:0004430)2.89032632
33Aplastic anemia (HP:0001915)2.81822464
34Absent hair (HP:0002298)2.76008593
35Abnormality of the parathyroid morphology (HP:0011766)2.75027299
36Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.73129322
3711 pairs of ribs (HP:0000878)2.67801364
38Flat acetabular roof (HP:0003180)2.61538762
39Growth hormone excess (HP:0000845)2.48189989
40Joint swelling (HP:0001386)2.46215757
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.38387046
42Abnormality of the calf musculature (HP:0001430)2.38077540
43Autoimmune thrombocytopenia (HP:0001973)2.36697647
44IgG deficiency (HP:0004315)2.29790020
45Recurrent fungal infections (HP:0002841)2.22788538
46Menstrual irregularities (HP:0000858)2.22617496
47Chronic mucocutaneous candidiasis (HP:0002728)2.15856115
48Recurrent cutaneous fungal infections (HP:0011370)2.15856115
49Renal cortical cysts (HP:0000803)2.15813457
50Combined immunodeficiency (HP:0005387)2.11330261
51Hypoplasia of the thymus (HP:0000778)2.08802244
52Seborrheic dermatitis (HP:0001051)2.07555855
53Abnormality of the fingertips (HP:0001211)2.06657859
54Impaired smooth pursuit (HP:0007772)2.04980770
55Encephalitis (HP:0002383)2.03668145
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.01884503
57Spontaneous abortion (HP:0005268)1.99885322
58Abnormality of eosinophils (HP:0001879)1.97928526
59Gaze-evoked nystagmus (HP:0000640)1.97454746
60Abnormality of the phalanges of the hallux (HP:0010057)1.96498227
61Recurrent viral infections (HP:0004429)1.94615197
62Gastrointestinal inflammation (HP:0004386)1.91864589
63Dysdiadochokinesis (HP:0002075)1.91746924
64Abnormality of T cell physiology (HP:0011840)1.88489349
65Dysmetric saccades (HP:0000641)1.82750871
66Abnormality of the proximal phalanges of the hand (HP:0009834)1.82017153
67Aplasia/Hypoplasia of the thymus (HP:0010515)1.81188612
68Thyroiditis (HP:0100646)1.80534832
69Female pseudohermaphroditism (HP:0010458)1.77769730
70Obstructive lung disease (HP:0006536)1.77492792
71Chronic obstructive pulmonary disease (HP:0006510)1.77492792
72Leukocytosis (HP:0001974)1.77405937
73Chronic diarrhea (HP:0002028)1.77328590
74Mediastinal lymphadenopathy (HP:0100721)1.75970281
75Microretrognathia (HP:0000308)1.73578624
76Deep palmar crease (HP:0006191)1.71759749
77Abnormality of the distal phalanges of the toes (HP:0010182)1.70679648
78Spontaneous hematomas (HP:0007420)1.70002547
79Neoplasm of the adrenal cortex (HP:0100641)1.69907727
80Abnormality of the 2nd finger (HP:0004100)1.67412428
81Broad face (HP:0000283)1.66589024
82Recurrent bronchitis (HP:0002837)1.64799251
83Stomatitis (HP:0010280)1.62795274
84Male pseudohermaphroditism (HP:0000037)1.62714823
85Radial bowing (HP:0002986)1.62708453
86Erectile abnormalities (HP:0100639)1.59776846
87Meningitis (HP:0001287)1.58387906
88Hypoproteinemia (HP:0003075)1.57467613
89Lower limb hyperreflexia (HP:0002395)1.56856586
90Gastrointestinal infarctions (HP:0005244)1.54274680
91Infertility (HP:0000789)1.53763060
92Vasculitis (HP:0002633)1.52177832
93Hyperthyroidism (HP:0000836)1.50658710
94Optic neuritis (HP:0100653)1.49391810
95Retrobulbar optic neuritis (HP:0100654)1.49391810
96Myokymia (HP:0002411)1.47966142
97Eczematoid dermatitis (HP:0000976)1.47764076
98Short 5th finger (HP:0009237)1.47626767
99Anorexia (HP:0002039)1.46887586
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.45133560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK28.20729541
2TAOK15.54514390
3CAMK1D5.10526213
4CAMK1G3.71884527
5FER3.53055921
6TESK23.20485027
7PIM23.19989829
8TXK2.80223973
9ARAF2.47709842
10MAP4K12.08208909
11MARK22.03940229
12RIPK42.00852349
13AKT31.99574001
14PRKD21.97089231
15RAF11.69598469
16ACVR1B1.69424602
17FES1.61527258
18TRIB31.55094860
19PRKCI1.36015081
20IRAK21.32794039
21MAP3K111.31985759
22IRAK31.06165251
23BRAF1.05922459
24ILK1.04934048
25CAMKK21.03739849
26CSK1.02798219
27GRK70.96007133
28EEF2K0.91448561
29PRKD30.89792726
30CDK70.89078638
31SMG10.87974154
32NLK0.85299237
33TESK10.81905646
34ERN10.80515199
35RPS6KA40.79790176
36ITK0.76377525
37TEC0.72281229
38MATK0.67534491
39LRRK20.63928322
40TAOK30.60418792
41IRAK40.59226076
42PIM10.58372359
43CDK120.57677792
44BTK0.56866708
45KDR0.53354974
46NUAK10.52670536
47GRK60.52478369
48STK110.51428746
49CSF1R0.50032038
50BCR0.49000631
51MAP2K20.48967947
52AURKA0.48627547
53MAP2K30.47443246
54JAK10.47337655
55CAMKK10.46062550
56CAMK10.45912479
57BMPR20.45409402
58MAP3K30.45249008
59PDK10.43885954
60TAOK20.42784157
61STK100.42597549
62CDK30.42164041
63LCK0.41359333
64BCKDK0.39983612
65MAPKAPK30.37956557
66MTOR0.36409261
67PRKD10.35435603
68MOS0.35210273
69PRKAA20.35185568
70SYK0.34582911
71FGR0.34567298
72DAPK10.34061926
73MAP2K60.31816719
74TGFBR20.30682576
75LYN0.30514471
76BLK0.30104176
77SGK2230.29986040
78SGK4940.29986040
79SIK20.28921427
80HCK0.28151843
81ZAP700.25158527
82BRSK20.25095649
83SGK30.24088154
84MARK30.23075104
85PDPK10.23066070
86PRKCQ0.22902445
87DAPK20.22512358
88GRK50.21359505
89IRAK10.20849346
90SGK20.19878264
91IKBKE0.19485896
92YES10.19039898
93MAPK80.17713292
94MAPK110.17246068
95PRKCZ0.17154765
96SIK30.16633861
97PRKAA10.16513019
98MAP3K140.16410079
99PDGFRB0.15378619
100CLK10.15240294

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.78500921
2Primary immunodeficiency_Homo sapiens_hsa053403.94645160
3Graft-versus-host disease_Homo sapiens_hsa053323.66979122
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.55388866
5Antigen processing and presentation_Homo sapiens_hsa046122.77010280
6Renin-angiotensin system_Homo sapiens_hsa046142.69970948
7T cell receptor signaling pathway_Homo sapiens_hsa046602.48582178
8Autoimmune thyroid disease_Homo sapiens_hsa053202.19496757
9Prostate cancer_Homo sapiens_hsa052152.15833383
10Allograft rejection_Homo sapiens_hsa053302.13477870
11Measles_Homo sapiens_hsa051621.76490610
12Acute myeloid leukemia_Homo sapiens_hsa052211.72588513
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71898515
14Type I diabetes mellitus_Homo sapiens_hsa049401.57613159
15Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.47694964
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.34438432
17Notch signaling pathway_Homo sapiens_hsa043301.30179357
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28588103
19Thyroid cancer_Homo sapiens_hsa052161.22589991
20Hematopoietic cell lineage_Homo sapiens_hsa046401.21639822
21Platelet activation_Homo sapiens_hsa046111.21479945
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17557878
23Non-small cell lung cancer_Homo sapiens_hsa052231.16593056
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14174920
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12460425
26Herpes simplex infection_Homo sapiens_hsa051681.11088769
27B cell receptor signaling pathway_Homo sapiens_hsa046621.10897685
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.10860426
29Colorectal cancer_Homo sapiens_hsa052101.06349937
30Chemokine signaling pathway_Homo sapiens_hsa040621.03857813
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03012093
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02376797
33Viral myocarditis_Homo sapiens_hsa054160.99696267
34Cholinergic synapse_Homo sapiens_hsa047250.97760109
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96848644
36Renin secretion_Homo sapiens_hsa049240.93309617
37mTOR signaling pathway_Homo sapiens_hsa041500.91262361
38VEGF signaling pathway_Homo sapiens_hsa043700.90742471
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90449540
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89294195
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89141270
42Ribosome_Homo sapiens_hsa030100.87117736
43Endometrial cancer_Homo sapiens_hsa052130.83540852
44Osteoclast differentiation_Homo sapiens_hsa043800.83363408
45Type II diabetes mellitus_Homo sapiens_hsa049300.81072303
46Leishmaniasis_Homo sapiens_hsa051400.77189151
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.76457190
48Long-term potentiation_Homo sapiens_hsa047200.75556752
49Hepatitis B_Homo sapiens_hsa051610.75350772
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75277948
51FoxO signaling pathway_Homo sapiens_hsa040680.73278910
52Apoptosis_Homo sapiens_hsa042100.72556411
53TNF signaling pathway_Homo sapiens_hsa046680.69455022
54Steroid biosynthesis_Homo sapiens_hsa001000.68795900
55Propanoate metabolism_Homo sapiens_hsa006400.67450827
56RNA polymerase_Homo sapiens_hsa030200.66770847
57Choline metabolism in cancer_Homo sapiens_hsa052310.66396108
58Endocytosis_Homo sapiens_hsa041440.66094781
59African trypanosomiasis_Homo sapiens_hsa051430.65290454
60Fatty acid metabolism_Homo sapiens_hsa012120.64955899
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.64595755
62Influenza A_Homo sapiens_hsa051640.64585030
63Hepatitis C_Homo sapiens_hsa051600.64069946
64Salmonella infection_Homo sapiens_hsa051320.64021402
65GnRH signaling pathway_Homo sapiens_hsa049120.63493041
66Lysine degradation_Homo sapiens_hsa003100.63461301
67Insulin signaling pathway_Homo sapiens_hsa049100.63400009
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63300026
69Malaria_Homo sapiens_hsa051440.61497437
70Glucagon signaling pathway_Homo sapiens_hsa049220.61346734
71Chronic myeloid leukemia_Homo sapiens_hsa052200.61287558
72Insulin resistance_Homo sapiens_hsa049310.60623794
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60188485
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.58587930
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58377892
76Pancreatic cancer_Homo sapiens_hsa052120.56737396
77Tuberculosis_Homo sapiens_hsa051520.55752672
78Peroxisome_Homo sapiens_hsa041460.55589776
79Regulation of autophagy_Homo sapiens_hsa041400.53072977
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.52452196
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51452746
82Prolactin signaling pathway_Homo sapiens_hsa049170.50864374
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50714189
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49078786
85Toxoplasmosis_Homo sapiens_hsa051450.48729166
86MAPK signaling pathway_Homo sapiens_hsa040100.47747766
87HTLV-I infection_Homo sapiens_hsa051660.46718749
88RNA degradation_Homo sapiens_hsa030180.44083220
89Shigellosis_Homo sapiens_hsa051310.43587777
90Nicotine addiction_Homo sapiens_hsa050330.42579628
91Serotonergic synapse_Homo sapiens_hsa047260.42014426
92Vitamin digestion and absorption_Homo sapiens_hsa049770.41921063
93cAMP signaling pathway_Homo sapiens_hsa040240.40652323
94Spliceosome_Homo sapiens_hsa030400.39711979
95Renal cell carcinoma_Homo sapiens_hsa052110.39246474
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38980467
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35440367
98Pathways in cancer_Homo sapiens_hsa052000.35153662
99Epstein-Barr virus infection_Homo sapiens_hsa051690.34476352
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.34072685

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