TRHDE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.86822264
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.68233498
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.45676638
4locomotory exploration behavior (GO:0035641)5.30837257
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30775761
6synaptic vesicle exocytosis (GO:0016079)5.19286212
7regulation of glutamate receptor signaling pathway (GO:1900449)5.16300520
8neuronal action potential propagation (GO:0019227)5.07092871
9glutamate secretion (GO:0014047)5.06004240
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.05529063
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.96718264
12neuron cell-cell adhesion (GO:0007158)4.94831878
13protein localization to synapse (GO:0035418)4.94449792
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.91046485
15glutamate receptor signaling pathway (GO:0007215)4.66906331
16synaptic transmission, glutamatergic (GO:0035249)4.66118828
17regulation of synaptic vesicle exocytosis (GO:2000300)4.60620940
18neurotransmitter-gated ion channel clustering (GO:0072578)4.56699281
19neuron-neuron synaptic transmission (GO:0007270)4.56033725
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.50471060
21synaptic vesicle maturation (GO:0016188)4.46441653
22gamma-aminobutyric acid transport (GO:0015812)4.44022433
23neurotransmitter secretion (GO:0007269)4.34889290
24protein heterotrimerization (GO:0070208)4.33538125
25exploration behavior (GO:0035640)4.23326537
26positive regulation of synapse maturation (GO:0090129)4.23308304
27regulation of synaptic vesicle transport (GO:1902803)4.12393493
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.12039592
29endocardial cushion development (GO:0003197)4.07352564
30presynaptic membrane assembly (GO:0097105)4.05108448
31cerebellar granule cell differentiation (GO:0021707)4.01119619
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98920445
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95429561
34positive regulation of membrane potential (GO:0045838)3.91063961
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90911896
36long-term memory (GO:0007616)3.89969337
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.89861279
38regulation of postsynaptic membrane potential (GO:0060078)3.79859694
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79492404
40regulation of neuronal synaptic plasticity (GO:0048168)3.76438584
41long-term synaptic potentiation (GO:0060291)3.74452694
42presynaptic membrane organization (GO:0097090)3.73686057
43neuron recognition (GO:0008038)3.72196026
44cerebellar Purkinje cell differentiation (GO:0021702)3.71778224
45layer formation in cerebral cortex (GO:0021819)3.62920775
46kidney mesenchyme development (GO:0072074)3.62561208
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61414861
48postsynaptic membrane organization (GO:0001941)3.57285199
49neurotransmitter transport (GO:0006836)3.52492223
50startle response (GO:0001964)3.50973904
51regulation of synapse structural plasticity (GO:0051823)3.50180136
52axonal fasciculation (GO:0007413)3.47332945
53dendritic spine morphogenesis (GO:0060997)3.46494737
54chondrocyte proliferation (GO:0035988)3.46276163
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.45489246
56regulation of synapse maturation (GO:0090128)3.45451902
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.45094348
58regulation of synaptic plasticity (GO:0048167)3.41848537
59sequestering of extracellular ligand from receptor (GO:0035581)3.34038787
60cellular response to vitamin (GO:0071295)3.33091953
61type B pancreatic cell proliferation (GO:0044342)3.30891731
62regulation of neurotransmitter secretion (GO:0046928)3.30852574
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.30683629
64regulation of neurotransmitter levels (GO:0001505)3.29966746
65response to histamine (GO:0034776)3.29587814
66mesodermal cell differentiation (GO:0048333)3.29046711
67cellular potassium ion homeostasis (GO:0030007)3.28868250
68regulation of dendritic spine morphogenesis (GO:0061001)3.27014837
69membrane depolarization (GO:0051899)3.24190317
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22969026
71collagen fibril organization (GO:0030199)3.19198991
72extracellular matrix assembly (GO:0085029)3.18742336
73positive regulation of synapse assembly (GO:0051965)3.18408889
74synaptic vesicle endocytosis (GO:0048488)3.15797593
75synapse assembly (GO:0007416)3.15201441
76transmission of nerve impulse (GO:0019226)3.13856972
77membrane hyperpolarization (GO:0060081)3.13200107
78hypotonic response (GO:0006971)3.12009400
79activation of protein kinase A activity (GO:0034199)3.10330718
80proline transport (GO:0015824)3.10272130
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10212625
82negative regulation of axon extension involved in axon guidance (GO:0048843)3.09701669
83mesenchymal-epithelial cell signaling (GO:0060638)3.08887038
84smooth muscle tissue development (GO:0048745)3.06266161
85positive regulation of synaptic transmission (GO:0050806)3.05656197
86dermatan sulfate biosynthetic process (GO:0030208)3.04809187
87positive regulation of fibroblast migration (GO:0010763)3.04646407
88urinary tract smooth muscle contraction (GO:0014848)3.03789723
89regulation of neurotransmitter transport (GO:0051588)3.02796757
90membrane depolarization during action potential (GO:0086010)3.02615090
91synaptic transmission (GO:0007268)3.02208801
92regulation of glutamate secretion (GO:0014048)3.01016001
93positive regulation of neurotransmitter transport (GO:0051590)3.00357209
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98485296
95learning (GO:0007612)2.98465883
96regulation of vesicle fusion (GO:0031338)2.98354572
97regulation of cAMP-dependent protein kinase activity (GO:2000479)2.98107901
98bone trabecula formation (GO:0060346)2.96702634
99regulation of synaptic transmission (GO:0050804)2.96554894
100regulation of dendritic spine development (GO:0060998)2.96217096
101long term synaptic depression (GO:0060292)2.93037466
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92505919
103positive regulation of neurotransmitter secretion (GO:0001956)2.91857876
104behavioral response to cocaine (GO:0048148)2.91615577
105negative regulation of smooth muscle cell migration (GO:0014912)2.89528002
106cell differentiation in hindbrain (GO:0021533)2.89302048
107regulation of voltage-gated calcium channel activity (GO:1901385)2.88860139
108synapse organization (GO:0050808)2.88349118
109cell adhesion mediated by integrin (GO:0033627)2.85841080
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84609236
111cell migration involved in heart development (GO:0060973)2.84015139
112response to gravity (GO:0009629)2.83677102
113neuromuscular process controlling posture (GO:0050884)2.82835619
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81974220
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80520895
116neuromuscular process controlling balance (GO:0050885)2.80356059
117dermatan sulfate metabolic process (GO:0030205)2.80331685
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79149734
119negative regulation of homotypic cell-cell adhesion (GO:0034111)2.78571417
120intraspecies interaction between organisms (GO:0051703)2.77959250
121social behavior (GO:0035176)2.77959250
122positive regulation of dendritic spine development (GO:0060999)2.76027002
123neuromuscular process (GO:0050905)2.75713558
124negative regulation of axon guidance (GO:1902668)2.73469150
125dendrite morphogenesis (GO:0048813)2.73421024
126innervation (GO:0060384)2.72916092
127behavioral defense response (GO:0002209)2.71878859
128behavioral fear response (GO:0001662)2.71878859
129relaxation of smooth muscle (GO:0044557)2.71553566
130pericardium development (GO:0060039)2.71245162
131metanephric mesenchyme development (GO:0072075)2.70886945
132positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70806624
133endodermal cell differentiation (GO:0035987)2.69859127
134protein localization to cell surface (GO:0034394)2.69246150
135heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.67914879
136cellular response to vitamin D (GO:0071305)2.65555416
137regulation of axon extension involved in axon guidance (GO:0048841)2.65270966
138negative regulation of fatty acid transport (GO:2000192)2.62012138
139adhesion of symbiont to host cell (GO:0044650)2.61052465
140virion attachment to host cell (GO:0019062)2.61052465
141negative regulation of osteoblast proliferation (GO:0033689)2.60664302
142inner ear receptor cell development (GO:0060119)2.60597915
143skin morphogenesis (GO:0043589)2.59090219
144substrate adhesion-dependent cell spreading (GO:0034446)2.54643863
145positive regulation of endothelial cell apoptotic process (GO:2000353)2.47740858
146G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.47565383
147regulation of axon guidance (GO:1902667)2.47053537
148positive regulation of axon extension (GO:0045773)2.45500257
149negative regulation of hormone biosynthetic process (GO:0032353)2.38899572
150positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38823766
151positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.32361038
152tonic smooth muscle contraction (GO:0014820)2.31946097
153positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30094822
154negative regulation of nitric-oxide synthase activity (GO:0051001)2.29654639
155retinal cone cell development (GO:0046549)2.29141156
156negative regulation of protein localization to cell surface (GO:2000009)2.28098290
157sleep (GO:0030431)2.27078157
158substrate-dependent cell migration (GO:0006929)2.25973336
159heparan sulfate proteoglycan metabolic process (GO:0030201)2.25337916
160anterior/posterior axis specification, embryo (GO:0008595)2.25101269
161SMAD protein complex assembly (GO:0007183)2.23662648
162positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.22971389
163cGMP-mediated signaling (GO:0019934)2.19979012
164negative regulation of hormone metabolic process (GO:0032351)2.19352732
165regulation of synaptic transmission, GABAergic (GO:0032228)2.16843508
166cellular response to epinephrine stimulus (GO:0071872)2.16637253
167serotonin metabolic process (GO:0042428)2.15873966
168positive regulation of male gonad development (GO:2000020)2.15532860
169negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.15314781
170cell migration involved in sprouting angiogenesis (GO:0002042)2.14967920
171positive regulation of cGMP metabolic process (GO:0030825)2.13105691
172regulation of cGMP metabolic process (GO:0030823)2.11559516
173response to magnesium ion (GO:0032026)2.09974586
174positive regulation of catecholamine secretion (GO:0033605)2.09454287
175regulation of smooth muscle cell migration (GO:0014910)2.08792598
176axon extension (GO:0048675)2.08112417
177cell-substrate junction assembly (GO:0007044)2.06338586
178negative regulation of leukocyte chemotaxis (GO:0002689)2.05735511
179cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.03977593
180endocrine hormone secretion (GO:0060986)2.03859248
181positive regulation of fatty acid beta-oxidation (GO:0032000)2.03588381
182lymphangiogenesis (GO:0001946)2.03482877
183relaxation of muscle (GO:0090075)2.02489366
184adhesion of symbiont to host (GO:0044406)2.01719774
185protein targeting to plasma membrane (GO:0072661)2.01421272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72716333
2GBX2_23144817_ChIP-Seq_PC3_Human4.11796909
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09212611
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06378050
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05780014
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.85016516
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66300939
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66300939
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56357668
10REST_21632747_ChIP-Seq_MESCs_Mouse2.56282817
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54966601
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52301719
13TAF15_26573619_Chip-Seq_HEK293_Human2.45563663
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43359330
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.43225764
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38515289
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.35921652
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35220591
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22484593
20DROSHA_22980978_ChIP-Seq_HELA_Human2.18575998
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16213387
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10601016
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07616754
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.02461365
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01398995
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00400103
27AR_21572438_ChIP-Seq_LNCaP_Human1.97477689
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.97305421
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95417686
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89012796
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87939824
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.81788340
33CJUN_26792858_Chip-Seq_BT549_Human1.80172182
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77845737
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.77151432
36* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72973159
37BRD4_25478319_ChIP-Seq_HGPS_Human1.72824740
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.71633538
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71606002
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69510364
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69510364
42P300_19829295_ChIP-Seq_ESCs_Human1.68593240
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58757037
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57420831
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57247946
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51633841
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.50233876
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.49943781
49* CBX2_27304074_Chip-Seq_ESCs_Mouse1.49886491
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49207481
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.48506950
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44461204
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.44358081
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42556802
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39997950
56AR_25329375_ChIP-Seq_VCAP_Human1.39102456
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38924358
58* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38283605
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36472084
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35223814
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34848594
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34615080
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33154867
64FUS_26573619_Chip-Seq_HEK293_Human1.32717794
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31637632
66ZNF274_21170338_ChIP-Seq_K562_Hela1.27643898
67* STAT3_23295773_ChIP-Seq_U87_Human1.26734447
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26612388
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.26488191
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20842015
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20528789
72RNF2_27304074_Chip-Seq_NSC_Mouse1.19926012
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.19812355
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19324397
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.18035867
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17686504
77VDR_22108803_ChIP-Seq_LS180_Human1.17588627
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17359279
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16944386
80* TCF4_23295773_ChIP-Seq_U87_Human1.16732927
81* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16585175
82ER_23166858_ChIP-Seq_MCF-7_Human1.15606564
83* AR_19668381_ChIP-Seq_PC3_Human1.15267402
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14068736
85AHR_22903824_ChIP-Seq_MCF-7_Human1.11322961
86BCAT_22108803_ChIP-Seq_LS180_Human1.09183615
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08381780
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08179501
89RUNX2_22187159_ChIP-Seq_PCA_Human1.08149889
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07771304
91* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07700285
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06640482
93IGF1R_20145208_ChIP-Seq_DFB_Human1.06011081
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05244381
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05244381
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04983768
97TP53_18474530_ChIP-ChIP_U2OS_Human1.04452159
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04402698
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04067336
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03820015
101TP53_16413492_ChIP-PET_HCT116_Human1.02331799
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.02111309
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00758136
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99682615
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98719944
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98397803
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98154059
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.97084292
109* TP53_20018659_ChIP-ChIP_R1E_Mouse0.97074034
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96281284
111* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96201155
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95989351
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95821316
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95629598
115TP53_23651856_ChIP-Seq_MEFs_Mouse0.95621247
116KDM2B_26808549_Chip-Seq_REH_Human0.95571424
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95153988
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.94888047
119JUN_21703547_ChIP-Seq_K562_Human0.94617820
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94408913
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93854020
122* RING1B_27294783_Chip-Seq_NPCs_Mouse0.93179908
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92877918
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90774439
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89816121
126RXR_22108803_ChIP-Seq_LS180_Human0.89346754
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88975149
128CBP_20019798_ChIP-Seq_JUKART_Human0.88975149
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88890447
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.86934493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.85425898
2MP0008438_abnormal_cutaneous_collagen5.15224239
3MP0003880_abnormal_central_pattern4.96762439
4MP0003635_abnormal_synaptic_transmissio4.12380097
5MP0009046_muscle_twitch3.82739054
6MP0004270_analgesia3.59546471
7MP0009745_abnormal_behavioral_response3.50354009
8MP0002064_seizures3.39123797
9MP0002063_abnormal_learning/memory/cond3.27422895
10MP0004272_abnormal_basement_membrane3.12956784
11MP0005503_abnormal_tendon_morphology3.12491791
12MP0001968_abnormal_touch/_nociception3.11625909
13MP0003705_abnormal_hypodermis_morpholog3.10844940
14MP0003279_aneurysm3.04468895
15MP0002572_abnormal_emotion/affect_behav2.96087544
16MP0001958_emphysema2.95688818
17MP0003950_abnormal_plasma_membrane2.95661274
18MP0002272_abnormal_nervous_system2.91989705
19MP0001486_abnormal_startle_reflex2.66967873
20MP0002734_abnormal_mechanical_nocicepti2.63946771
21MP0009384_cardiac_valve_regurgitation2.60428299
22MP0005623_abnormal_meninges_morphology2.56786401
23MP0002736_abnormal_nociception_after2.54202287
24MP0001501_abnormal_sleep_pattern2.47595012
25MP0002735_abnormal_chemical_nociception2.40334049
26MP0001440_abnormal_grooming_behavior2.36363674
27MP0005423_abnormal_somatic_nervous2.28228364
28MP0002067_abnormal_sensory_capabilities2.25872223
29MP0005670_abnormal_white_adipose2.21136557
30MP0005275_abnormal_skin_tensile2.16631884
31MP0005257_abnormal_intraocular_pressure2.13139326
32MP0006054_spinal_hemorrhage1.99660253
33MP0001542_abnormal_bone_strength1.99026364
34MP0001970_abnormal_pain_threshold1.89049822
35MP0003329_amyloid_beta_deposits1.88317292
36MP0003879_abnormal_hair_cell1.87935707
37MP0006276_abnormal_autonomic_nervous1.85585173
38MP0002184_abnormal_innervation1.85381320
39MP0002733_abnormal_thermal_nociception1.84953797
40MP0008569_lethality_at_weaning1.83192489
41MP0000534_abnormal_ureter_morphology1.81768445
42MP0004130_abnormal_muscle_cell1.80944935
43MP0004924_abnormal_behavior1.79245474
44MP0005386_behavior/neurological_phenoty1.79245474
45MP0000778_abnormal_nervous_system1.75581149
46MP0002557_abnormal_social/conspecific_i1.73324939
47MP0009780_abnormal_chondrocyte_physiolo1.67959700
48MP0005595_abnormal_vascular_smooth1.67404825
49MP0005646_abnormal_pituitary_gland1.64637495
50MP0001299_abnormal_eye_distance/1.63221060
51MP0001984_abnormal_olfaction1.61100000
52MP0004142_abnormal_muscle_tone1.56129645
53MP0003091_abnormal_cell_migration1.53199328
54MP0002295_abnormal_pulmonary_circulatio1.52203118
55MP0010368_abnormal_lymphatic_system1.50889141
56MP0003566_abnormal_cell_adhesion1.49842796
57MP0004811_abnormal_neuron_physiology1.46836881
58MP0005645_abnormal_hypothalamus_physiol1.45740232
59MP0000955_abnormal_spinal_cord1.44418002
60MP0002066_abnormal_motor_capabilities/c1.43633338
61MP0005551_abnormal_eye_electrophysiolog1.42928146
62MP0000569_abnormal_digit_pigmentation1.41451368
63MP0003283_abnormal_digestive_organ1.40239477
64MP0002882_abnormal_neuron_morphology1.37024144
65MP0004858_abnormal_nervous_system1.36279517
66MP0001348_abnormal_lacrimal_gland1.35586514
67MP0002837_dystrophic_cardiac_calcinosis1.34731675
68MP0001529_abnormal_vocalization1.31532056
69MP0002822_catalepsy1.30652400
70MP0003942_abnormal_urinary_system1.30509326
71MP0003633_abnormal_nervous_system1.29513857
72MP0005508_abnormal_skeleton_morphology1.24702650
73MP0000751_myopathy1.23432184
74MP0002896_abnormal_bone_mineralization1.21917489
75MP0003787_abnormal_imprinting1.20357224
76MP0002876_abnormal_thyroid_physiology1.19221289
77MP0003631_nervous_system_phenotype1.15540147
78MP0000538_abnormal_urinary_bladder1.13917182
79MP0000767_abnormal_smooth_muscle1.13108203
80MP0001188_hyperpigmentation1.11951189
81MP0009250_abnormal_appendicular_skeleto1.11468196
82MP0001502_abnormal_circadian_rhythm1.11285531
83MP0008872_abnormal_physiological_respon1.11144363
84MP0004742_abnormal_vestibular_system1.10003535
85MP0002909_abnormal_adrenal_gland1.09394048
86MP0003868_abnormal_feces_composition1.06706343
87MP0002971_abnormal_brown_adipose1.06378076
88MP0000749_muscle_degeneration1.05841488
89MP0000230_abnormal_systemic_arterial1.05815966
90MP0002152_abnormal_brain_morphology1.04589157
91MP0002229_neurodegeneration1.04442857
92MP0004885_abnormal_endolymph1.03039969
93MP0004145_abnormal_muscle_electrophysio1.02154256
94MP0010352_gastrointestinal_tract_polyps1.01501023
95MP0008874_decreased_physiological_sensi1.00124510
96MP0009053_abnormal_anal_canal0.99999802
97MP0003122_maternal_imprinting0.98423247
98MP0003690_abnormal_glial_cell0.98344709
99MP0004036_abnormal_muscle_relaxation0.98044457
100MP0005023_abnormal_wound_healing0.97844079
101MP0005620_abnormal_muscle_contractility0.97770753
102MP0003941_abnormal_skin_development0.97173565
103MP0001905_abnormal_dopamine_level0.96603906
104MP0001963_abnormal_hearing_physiology0.95320818
105MP0003959_abnormal_lean_body0.94626531
106MP0004084_abnormal_cardiac_muscle0.94191456
107MP0005535_abnormal_body_temperature0.93374687
108MP0000604_amyloidosis0.92800369
109MP0000428_abnormal_craniofacial_morphol0.91193006
110MP0003632_abnormal_nervous_system0.90945433
111MP0002069_abnormal_eating/drinking_beha0.90860475
112MP0001177_atelectasis0.88987012
113MP0004085_abnormal_heartbeat0.88372039
114MP0008004_abnormal_stomach_pH0.87880694
115MP0006138_congestive_heart_failure0.87746440
116MP0003045_fibrosis0.87488102
117MP0000013_abnormal_adipose_tissue0.85650459
118MP0010386_abnormal_urinary_bladder0.85417618
119MP0005187_abnormal_penis_morphology0.84794908
120MP0004215_abnormal_myocardial_fiber0.84774689
121MP0003252_abnormal_bile_duct0.83446755
122MP0002108_abnormal_muscle_morphology0.83311068
123MP0002752_abnormal_somatic_nervous0.81894274
124MP0003646_muscle_fatigue0.81520692
125MP0004484_altered_response_of0.80522347
126MP0000003_abnormal_adipose_tissue0.80405737
127MP0004043_abnormal_pH_regulation0.80084017
128MP0004134_abnormal_chest_morphology0.78799031
129MP0000920_abnormal_myelination0.76541484
130MP0000631_abnormal_neuroendocrine_gland0.75557679
131MP0008875_abnormal_xenobiotic_pharmacok0.75104072
132MP0003385_abnormal_body_wall0.72992977
133MP0005375_adipose_tissue_phenotype0.72653907
134MP0005666_abnormal_adipose_tissue0.72013114
135MP0002090_abnormal_vision0.71369487
136MP0003634_abnormal_glial_cell0.68275125
137MP0003075_altered_response_to0.65396604
138MP0005394_taste/olfaction_phenotype0.64858089
139MP0005499_abnormal_olfactory_system0.64858089
140MP0001664_abnormal_digestion0.64450871
141MP0000733_abnormal_muscle_development0.64410915
142MP0003137_abnormal_impulse_conducting0.63209586
143MP0000427_abnormal_hair_cycle0.61766372
144MP0000163_abnormal_cartilage_morphology0.61249850
145MP0000759_abnormal_skeletal_muscle0.60408762
146MP0005360_urolithiasis0.60005257
147MP0002115_abnormal_skeleton_extremities0.59802550
148MP0001485_abnormal_pinna_reflex0.59159208
149MP0001943_abnormal_respiration0.55206518
150MP0005085_abnormal_gallbladder_physiolo0.54628872
151MP0000026_abnormal_inner_ear0.54397650
152MP0010770_preweaning_lethality0.53976068
153MP0002082_postnatal_lethality0.53976068
154MP0010329_abnormal_lipoprotein_level0.53940477
155MP0004233_abnormal_muscle_weight0.53738788
156MP0010769_abnormal_survival0.53294073
157MP0006072_abnormal_retinal_apoptosis0.53222185
158MP0002638_abnormal_pupillary_reflex0.51449390
159MP0005253_abnormal_eye_physiology0.50341121
160MP0010768_mortality/aging0.49951368
161MP0003956_abnormal_body_size0.48637113

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.29931254
2Premature rupture of membranes (HP:0001788)6.48031999
3Focal seizures (HP:0007359)5.87591208
4Atonic seizures (HP:0010819)5.80396671
5Myokymia (HP:0002411)5.79810164
6Aortic aneurysm (HP:0004942)5.75770630
7Protrusio acetabuli (HP:0003179)5.64295744
8Epileptic encephalopathy (HP:0200134)5.54821567
9Febrile seizures (HP:0002373)5.11385595
10Aortic dissection (HP:0002647)5.03838340
11Hyperventilation (HP:0002883)4.97109427
12Visual hallucinations (HP:0002367)4.92442656
13Progressive cerebellar ataxia (HP:0002073)4.91265670
14Absence seizures (HP:0002121)4.80597589
15Ankle contracture (HP:0006466)4.49881424
16Follicular hyperkeratosis (HP:0007502)4.35235117
17Dialeptic seizures (HP:0011146)4.25560523
18Generalized tonic-clonic seizures (HP:0002069)4.19073622
19Gaze-evoked nystagmus (HP:0000640)4.02867231
20Action tremor (HP:0002345)4.00249488
21Broad-based gait (HP:0002136)3.97569398
22Vascular tortuosity (HP:0004948)3.91485140
23Type 1 muscle fiber predominance (HP:0003803)3.72929267
24Dysdiadochokinesis (HP:0002075)3.72594379
25Spinal rigidity (HP:0003306)3.70999416
26Impaired vibration sensation in the lower limbs (HP:0002166)3.68113239
27Neonatal short-limb short stature (HP:0008921)3.67894509
28Soft skin (HP:0000977)3.59570515
29Scanning speech (HP:0002168)3.50056409
30Bladder diverticulum (HP:0000015)3.38537895
31Dysmetria (HP:0001310)3.35834337
32Arterial tortuosity (HP:0005116)3.35554694
33Abnormality of dentin (HP:0010299)3.34777998
34Slender build (HP:0001533)3.33603087
35Hypoventilation (HP:0002791)3.30425946
36Poor eye contact (HP:0000817)3.20351489
37Amblyopia (HP:0000646)3.13454893
38Broad metatarsal (HP:0001783)3.10278872
39Shallow orbits (HP:0000586)3.07856763
40Excessive salivation (HP:0003781)3.04598170
41Drooling (HP:0002307)3.04598170
42Wormian bones (HP:0002645)3.03919908
43Atrophic scars (HP:0001075)3.02724580
44Abnormal social behavior (HP:0012433)3.01425460
45Impaired social interactions (HP:0000735)3.01425460
46Truncal ataxia (HP:0002078)2.96775275
47Genetic anticipation (HP:0003743)2.96470463
48Status epilepticus (HP:0002133)2.93358031
49Epileptiform EEG discharges (HP:0011182)2.89467196
50Abnormal eating behavior (HP:0100738)2.89308938
51Impaired smooth pursuit (HP:0007772)2.88526251
52Dysmetric saccades (HP:0000641)2.82010113
53Abnormality of the lower motor neuron (HP:0002366)2.80199830
54Wide anterior fontanel (HP:0000260)2.77141420
55Urinary bladder sphincter dysfunction (HP:0002839)2.71363458
56Postural instability (HP:0002172)2.70418572
57Genu recurvatum (HP:0002816)2.68387577
58Anxiety (HP:0000739)2.65401409
59EEG with generalized epileptiform discharges (HP:0011198)2.64002152
60Depression (HP:0000716)2.58697606
61Impaired vibratory sensation (HP:0002495)2.57668487
62Abnormality of binocular vision (HP:0011514)2.57278798
63Diplopia (HP:0000651)2.57278798
64Supranuclear gaze palsy (HP:0000605)2.55770497
65Absent speech (HP:0001344)2.55296816
66Bowel diverticulosis (HP:0005222)2.52220723
67Increased mean platelet volume (HP:0011877)2.52090151
68Hemiplegia (HP:0002301)2.51900575
69Abnormality of the corticospinal tract (HP:0002492)2.50474319
70Abnormality of ocular smooth pursuit (HP:0000617)2.49205312
71Protruding tongue (HP:0010808)2.48705408
72Overgrowth (HP:0001548)2.48605838
73Hemiparesis (HP:0001269)2.47458085
74Increased variability in muscle fiber diameter (HP:0003557)2.47349290
75Progressive inability to walk (HP:0002505)2.47270676
76Spastic gait (HP:0002064)2.47039877
77Intention tremor (HP:0002080)2.46345061
78Hypsarrhythmia (HP:0002521)2.46287404
79Termporal pattern (HP:0011008)2.45665352
80Insidious onset (HP:0003587)2.45665352
81Generalized myoclonic seizures (HP:0002123)2.44469709
82Inability to walk (HP:0002540)2.42875150
83Fragile skin (HP:0001030)2.42452614
84Polyphagia (HP:0002591)2.41491532
85Abnormality of saccadic eye movements (HP:0000570)2.36857127
86Cerebral inclusion bodies (HP:0100314)2.31130996
87Mitral valve prolapse (HP:0001634)2.29161358
88Blue irides (HP:0000635)2.28691879
89Peritonitis (HP:0002586)2.28497548
90Knee flexion contracture (HP:0006380)2.27178081
91Mildly elevated creatine phosphokinase (HP:0008180)2.26974467
92Spondylolisthesis (HP:0003302)2.26260717
93Aortic regurgitation (HP:0001659)2.24422465
94Bradykinesia (HP:0002067)2.23856249
95Ankle clonus (HP:0011448)2.23153406
96Elbow flexion contracture (HP:0002987)2.22609414
97Mild short stature (HP:0003502)2.22550171
98Mutism (HP:0002300)2.22239795
99Fetal akinesia sequence (HP:0001989)2.22183383
100Cervical subluxation (HP:0003308)2.21955276
101Urinary urgency (HP:0000012)2.21198923
102Dilatation of the ascending aorta (HP:0005111)2.20306669
103Long toe (HP:0010511)2.20003239
104Blue sclerae (HP:0000592)2.19417946
105Neurofibrillary tangles (HP:0002185)2.18549227
106Coronal craniosynostosis (HP:0004440)2.16801951
107Aneurysm (HP:0002617)2.14250750
108Hyperextensible skin (HP:0000974)2.14248811
109Gait ataxia (HP:0002066)2.13705357
110Gait imbalance (HP:0002141)2.13429100
111Keratoconus (HP:0000563)2.10399943
112Increased corneal curvature (HP:0100692)2.10399943
113Pheochromocytoma (HP:0002666)2.09118348
114Bradycardia (HP:0001662)2.08983084
115Stereotypic behavior (HP:0000733)2.08513485
116Morphological abnormality of the middle ear (HP:0008609)2.07061307
117Fair hair (HP:0002286)2.06598917
118Focal dystonia (HP:0004373)2.04637793
119Broad ribs (HP:0000885)2.03961552
120Abnormal platelet volume (HP:0011876)2.02496739
121Esotropia (HP:0000565)2.02345237
122Torticollis (HP:0000473)2.02340827
123Cardiovascular calcification (HP:0011915)2.01036355
124Abnormality of salivation (HP:0100755)2.00340001
125Complete atrioventricular canal defect (HP:0001674)2.00182862
126Distal upper limb amyotrophy (HP:0007149)1.97559722
127Upper limb amyotrophy (HP:0009129)1.97559722
128Generalized hypopigmentation of hair (HP:0011358)1.97556092
129Lower limb amyotrophy (HP:0007210)1.96202166
130Joint laxity (HP:0001388)1.95247918
131Mitral stenosis (HP:0001718)1.95073130
132Neuroendocrine neoplasm (HP:0100634)1.93452384
133Abnormality of proline metabolism (HP:0010907)1.92011985
134Hydroxyprolinuria (HP:0003080)1.92011985
135Agitation (HP:0000713)1.91146363
136Anterior segment dysgenesis (HP:0007700)1.90768368
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90345165
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.90345165
139Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90056559
140Hydroureter (HP:0000072)1.89401228
141Biconcave vertebral bodies (HP:0004586)1.88483478
142Aortic valve stenosis (HP:0001650)1.87689530
143Mitral regurgitation (HP:0001653)1.87142156
144Incomplete penetrance (HP:0003829)1.86812933
145Obstructive sleep apnea (HP:0002870)1.86752989
146Specific learning disability (HP:0001328)1.86285580
147Abnormality of skeletal muscle fiber size (HP:0012084)1.85749272
148Psychosis (HP:0000709)1.85572504
149Neuronal loss in central nervous system (HP:0002529)1.84928418
150Lower limb muscle weakness (HP:0007340)1.84356014
151Abnormal delivery (HP:0001787)1.83440537
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.83432829
153Absent/shortened dynein arms (HP:0200106)1.83432829
154Congenital primary aphakia (HP:0007707)1.82886525
155Abnormal ciliary motility (HP:0012262)1.82419903
156Hypoplasia of the iris (HP:0007676)1.80401958
157Abnormal hair whorl (HP:0010721)1.80190357
158Hyperthyroidism (HP:0000836)1.77202721
159Medial flaring of the eyebrow (HP:0010747)1.76141344
160Facial shape deformation (HP:0011334)1.74723387
161Potter facies (HP:0002009)1.74723387
162Limb ataxia (HP:0002070)1.73860200
163Narrow nasal bridge (HP:0000446)1.72954856
164Craniofacial dystonia (HP:0012179)1.71314685
165Ventricular fibrillation (HP:0001663)1.70390842
166Syringomyelia (HP:0003396)1.69983338
167Spinal cord lesions (HP:0100561)1.69983338
168Poor suck (HP:0002033)1.68671427
169Ulnar bowing (HP:0003031)1.66718844
170Morphological abnormality of the pyramidal tract (HP:0002062)1.66417391
171Prominent supraorbital ridges (HP:0000336)1.65625131
172Horizontal nystagmus (HP:0000666)1.65602408
173Ileus (HP:0002595)1.64963507
174Wrist flexion contracture (HP:0001239)1.64445665
175Buphthalmos (HP:0000557)1.64236556
176Abnormality of the anterior chamber (HP:0000593)1.64210849
177Osteolytic defects of the phalanges of the hand (HP:0009771)1.63374728
178Osteolytic defects of the hand bones (HP:0009699)1.63374728
179Bronchomalacia (HP:0002780)1.63330861
180Limb-girdle muscle weakness (HP:0003325)1.62899443
181Atrioventricular canal defect (HP:0006695)1.62815488
182Stridor (HP:0010307)1.62747475
183Round face (HP:0000311)1.62493679
184Ectopia lentis (HP:0001083)1.60008573
185Achilles tendon contracture (HP:0001771)1.59355880
186Type II lissencephaly (HP:0007260)1.59207963
187Abnormality of the acetabulum (HP:0003170)1.57577110
188Distal lower limb amyotrophy (HP:0008944)1.57240088
189Mesomelia (HP:0003027)1.56959990
190Deviation of the hallux (HP:0010051)1.56367061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.24542658
2EPHA44.22005724
3CASK4.09300497
4NTRK34.04144068
5MAP3K43.46801735
6MAP2K73.13102488
7MAP3K123.07475882
8DAPK22.88088617
9MAP3K92.62471071
10CDK192.53022519
11FRK2.51862197
12MAP2K42.46317392
13MARK12.46042915
14DDR22.34553697
15PDGFRA2.28066382
16PAK22.23982299
17MINK12.20611575
18PTK22.19211159
19NTRK22.07925001
20RIPK42.01169372
21DAPK11.94480630
22PAK61.78946533
23NEK91.70016513
24PLK21.63450149
25PIK3CG1.63325928
26TTN1.62300751
27ADRBK21.61584561
28LIMK11.60894247
29OXSR11.54288268
30CAMKK21.47878240
31SIK21.47471148
32GRK51.45587136
33MAPK131.43283775
34CAMKK11.41890891
35CDK51.39092681
36PRKCG1.37262894
37LMTK21.36165782
38NTRK11.35496363
39TNIK1.34236407
40PNCK1.33178864
41GRK11.33007598
42PRKD21.31450811
43FLT31.29729548
44TESK11.26486363
45PRKG21.23355278
46LATS11.22022772
47ROCK11.16725440
48CAMK2A1.15653224
49PRPF4B1.15357397
50SIK11.15193977
51KSR11.13908096
52EPHB21.12708455
53MET1.12026447
54PIM21.11556825
55KSR21.10326878
56STK381.09209997
57AKT31.08229306
58FES1.05499905
59CAMK2B1.05487598
60TRPM71.04895875
61SGK4941.01727720
62SGK2231.01727720
63CAMK10.99438610
64SGK20.97527862
65BMPR20.96678329
66CCNB10.96557398
67RIPK10.95689793
68PTK2B0.95488024
69MELK0.95156808
70PRKD30.92544784
71MAP2K10.88834114
72UHMK10.86334786
73PDGFRB0.84073454
74ARAF0.81510420
75STK110.78451716
76DMPK0.77972782
77CDK180.75625569
78ERBB40.74969048
79MAP3K130.74188889
80CDK150.73434869
81WNK40.71555859
82RPS6KA20.71226462
83BRAF0.70579712
84ACVR1B0.70292109
85PRKCH0.69208149
86CDK140.68669100
87ABL20.68646369
88STK390.68161296
89TRIB30.68099682
90PRKCE0.67915008
91SGK30.67836043
92CAMK40.67817921
93MOS0.67769683
94IRAK10.67568070
95SGK10.66583251
96CAMK2G0.65051590
97DYRK1B0.64947288
98PAK10.64904110
99DYRK1A0.64300477
100PHKG20.64049893
101PHKG10.64049893
102WNK30.63339036
103FGR0.62535848
104CAMK2D0.62396701
105MARK20.62083652
106NME10.61877028
107CDK11A0.61507233
108GSK3A0.60439115
109CAMK1G0.58874601
110PDK10.58243507
111PDK40.55802679
112PDK30.55802679
113PRKD10.55358895
114DAPK30.54598585
115MAP3K20.54561340
116MAP3K60.54322097
117MAPK120.53456322
118ROCK20.53310300
119WNK10.53247720
120FER0.53067260
121TYRO30.52496640
122PAK30.51533389
123PDPK10.50806885
124STK38L0.49885148
125ILK0.49254330
126PINK10.49253507
127LATS20.49138700
128CSNK1G20.48753824
129CDC42BPA0.47789228
130MTOR0.47365642
131TNK20.47154154
132RPS6KA30.47082192
133PRKCZ0.46494009
134SIK30.46055481
135PRKAA10.44775616
136BCR0.44751083
137INSRR0.44474972
138RET0.44395326
139FGFR20.43455027
140NEK60.42756213
141PIK3CA0.42597004
142FYN0.40363853
143PRKACA0.39772590
144BMX0.39515186
145TIE10.39163736
146ADRBK10.37219321
147PRKCB0.36522525
148GRK70.36278189
149MAPKAPK30.36232039
150MUSK0.36004742
151PRKG10.35966436
152PRKCA0.35670124
153CDK80.29963318

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41352625
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31023402
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90298056
4GABAergic synapse_Homo sapiens_hsa047272.75092234
5Glutamatergic synapse_Homo sapiens_hsa047242.72562287
6ECM-receptor interaction_Homo sapiens_hsa045122.66946748
7Long-term potentiation_Homo sapiens_hsa047202.60705087
8Circadian entrainment_Homo sapiens_hsa047132.59230436
9Morphine addiction_Homo sapiens_hsa050322.46725289
10Amphetamine addiction_Homo sapiens_hsa050312.35151783
11Olfactory transduction_Homo sapiens_hsa047402.27706066
12Salivary secretion_Homo sapiens_hsa049702.15533093
13Taste transduction_Homo sapiens_hsa047422.03674949
14Protein digestion and absorption_Homo sapiens_hsa049741.99019313
15Focal adhesion_Homo sapiens_hsa045101.97276801
16Collecting duct acid secretion_Homo sapiens_hsa049661.90304571
17Insulin secretion_Homo sapiens_hsa049111.88646140
18Dopaminergic synapse_Homo sapiens_hsa047281.88165757
19Long-term depression_Homo sapiens_hsa047301.84049389
20Gastric acid secretion_Homo sapiens_hsa049711.73739383
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70122425
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69303606
23Cholinergic synapse_Homo sapiens_hsa047251.65297744
24Calcium signaling pathway_Homo sapiens_hsa040201.63171046
25Renin secretion_Homo sapiens_hsa049241.57084617
26Serotonergic synapse_Homo sapiens_hsa047261.54466455
27PPAR signaling pathway_Homo sapiens_hsa033201.51080479
28Oxytocin signaling pathway_Homo sapiens_hsa049211.50665626
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46524615
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45676138
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45446996
32Cocaine addiction_Homo sapiens_hsa050301.27622686
33Phototransduction_Homo sapiens_hsa047441.26905470
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25576691
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25149219
36Nitrogen metabolism_Homo sapiens_hsa009101.22998760
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20390975
38Cardiac muscle contraction_Homo sapiens_hsa042601.19773453
39cAMP signaling pathway_Homo sapiens_hsa040241.19098042
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18515566
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18436752
42GnRH signaling pathway_Homo sapiens_hsa049121.17255211
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16050788
44Platelet activation_Homo sapiens_hsa046111.13327838
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11098741
46Proteoglycans in cancer_Homo sapiens_hsa052051.06834078
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06671244
48Type II diabetes mellitus_Homo sapiens_hsa049301.06190446
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06005423
50Gap junction_Homo sapiens_hsa045401.04564484
51Melanoma_Homo sapiens_hsa052181.03056704
52Axon guidance_Homo sapiens_hsa043601.02572034
53Vibrio cholerae infection_Homo sapiens_hsa051101.01552068
54Hippo signaling pathway_Homo sapiens_hsa043901.01152668
55Oxidative phosphorylation_Homo sapiens_hsa001900.96700222
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96521595
57Arginine biosynthesis_Homo sapiens_hsa002200.95170165
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91211763
59Renin-angiotensin system_Homo sapiens_hsa046140.90929020
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89557215
61Estrogen signaling pathway_Homo sapiens_hsa049150.88951848
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88946945
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88509186
64Alzheimers disease_Homo sapiens_hsa050100.87488973
65Butanoate metabolism_Homo sapiens_hsa006500.83791628
66ErbB signaling pathway_Homo sapiens_hsa040120.82933131
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.80012799
68Bile secretion_Homo sapiens_hsa049760.79044081
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78970184
70Pancreatic secretion_Homo sapiens_hsa049720.78546382
71Melanogenesis_Homo sapiens_hsa049160.76983809
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76284600
73Amoebiasis_Homo sapiens_hsa051460.76193948
74Fat digestion and absorption_Homo sapiens_hsa049750.75912186
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.74861423
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73842402
77Thyroid hormone synthesis_Homo sapiens_hsa049180.71286081
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70910202
79Glioma_Homo sapiens_hsa052140.70390472
80Fatty acid metabolism_Homo sapiens_hsa012120.70278465
81beta-Alanine metabolism_Homo sapiens_hsa004100.68110125
82Adherens junction_Homo sapiens_hsa045200.67731279
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66543688
84Tight junction_Homo sapiens_hsa045300.65405861
85Dilated cardiomyopathy_Homo sapiens_hsa054140.64643019
86Wnt signaling pathway_Homo sapiens_hsa043100.63420672
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63162697
88Hedgehog signaling pathway_Homo sapiens_hsa043400.61679161
89Sulfur metabolism_Homo sapiens_hsa009200.58703718
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58489507
91Basal cell carcinoma_Homo sapiens_hsa052170.55938879
92AMPK signaling pathway_Homo sapiens_hsa041520.55927719
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54547210
94Glucagon signaling pathway_Homo sapiens_hsa049220.53867718
95TGF-beta signaling pathway_Homo sapiens_hsa043500.53697983
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53093699
97Fatty acid elongation_Homo sapiens_hsa000620.52362155
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.52058025
99MAPK signaling pathway_Homo sapiens_hsa040100.50597231
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.50085112
101Pathways in cancer_Homo sapiens_hsa052000.50077840
102Parkinsons disease_Homo sapiens_hsa050120.47694357
103Sphingolipid metabolism_Homo sapiens_hsa006000.47245738
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44288636
105Oocyte meiosis_Homo sapiens_hsa041140.44206388
106Fatty acid degradation_Homo sapiens_hsa000710.43961305
107Pyruvate metabolism_Homo sapiens_hsa006200.42301584
108Choline metabolism in cancer_Homo sapiens_hsa052310.42204220
109Small cell lung cancer_Homo sapiens_hsa052220.41606887
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.41199011
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39170762
112Inositol phosphate metabolism_Homo sapiens_hsa005620.38700865
113Dorso-ventral axis formation_Homo sapiens_hsa043200.38468243
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.38462173
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38150374
116Ras signaling pathway_Homo sapiens_hsa040140.38047817
117African trypanosomiasis_Homo sapiens_hsa051430.37596274
118Ovarian steroidogenesis_Homo sapiens_hsa049130.36735628
119Fatty acid biosynthesis_Homo sapiens_hsa000610.35453019
120Circadian rhythm_Homo sapiens_hsa047100.35335685
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35002618
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33481431
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32226993
124Huntingtons disease_Homo sapiens_hsa050160.31829732
125Type I diabetes mellitus_Homo sapiens_hsa049400.30666964
126Rap1 signaling pathway_Homo sapiens_hsa040150.30612586
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30549002
128Rheumatoid arthritis_Homo sapiens_hsa053230.28640694
129Prion diseases_Homo sapiens_hsa050200.28393626
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26735053
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24408875
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23812613
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23121242
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.22432431
135VEGF signaling pathway_Homo sapiens_hsa043700.22061470
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21463950
137Glycerolipid metabolism_Homo sapiens_hsa005610.20203272

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