TRHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.89017154
2regulation of pigment cell differentiation (GO:0050932)6.39997961
3positive regulation of developmental pigmentation (GO:0048087)5.79591548
4regulation of penile erection (GO:0060405)5.59716977
5negative regulation of heart rate (GO:0010459)5.57884693
6chemosensory behavior (GO:0007635)5.52570070
7short-term memory (GO:0007614)5.27652329
8neuron cell-cell adhesion (GO:0007158)5.18971016
9thrombin receptor signaling pathway (GO:0070493)4.94840926
10vocalization behavior (GO:0071625)4.93518181
11positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.73522899
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59801805
13negative regulation of norepinephrine secretion (GO:0010700)4.55076185
14sequestering of actin monomers (GO:0042989)4.48812031
15regulation of phospholipid biosynthetic process (GO:0071071)4.41568348
16regulation of glutamate receptor signaling pathway (GO:1900449)4.38206364
17protein K6-linked ubiquitination (GO:0085020)4.36713512
18detection of calcium ion (GO:0005513)4.35869105
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.34320497
20synaptic vesicle exocytosis (GO:0016079)4.33875552
21negative regulation of astrocyte differentiation (GO:0048712)4.33781238
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28878318
23regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21369018
24L-amino acid import (GO:0043092)4.21111291
25regulation of centriole replication (GO:0046599)4.10390782
26behavioral response to ethanol (GO:0048149)4.05337441
27neuron recognition (GO:0008038)4.00605177
28glutamate receptor signaling pathway (GO:0007215)3.94218181
29neuron-neuron synaptic transmission (GO:0007270)3.91240108
30startle response (GO:0001964)3.85979471
31locomotory exploration behavior (GO:0035641)3.83152991
32presynaptic membrane assembly (GO:0097105)3.81228537
33replication fork processing (GO:0031297)3.81076041
34opioid receptor signaling pathway (GO:0038003)3.78492289
35axonal fasciculation (GO:0007413)3.78470065
36synaptic transmission, glutamatergic (GO:0035249)3.77254971
37myelination in peripheral nervous system (GO:0022011)3.70966933
38peripheral nervous system axon ensheathment (GO:0032292)3.70966933
39proline transport (GO:0015824)3.70444406
40dopamine transport (GO:0015872)3.69303918
41glycine transport (GO:0015816)3.68230924
42postsynaptic membrane organization (GO:0001941)3.67517013
43spermatid nucleus differentiation (GO:0007289)3.67337458
44regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.66002518
45regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.66002518
46positive regulation of fibroblast migration (GO:0010763)3.65629776
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61025646
48regulation of synaptic vesicle exocytosis (GO:2000300)3.60140287
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.57513251
50exploration behavior (GO:0035640)3.57449865
51synapse assembly (GO:0007416)3.55325022
52negative regulation of cation channel activity (GO:2001258)3.55087458
53L-serine metabolic process (GO:0006563)3.54870629
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54482320
55mitochondrial genome maintenance (GO:0000002)3.54196253
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52721249
57glutamate secretion (GO:0014047)3.52053259
58negative regulation of calcium ion transmembrane transport (GO:1903170)3.49044501
59negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.49044501
60regulation of integrin-mediated signaling pathway (GO:2001044)3.47448562
61protein localization to synapse (GO:0035418)3.46974618
62neurotransmitter secretion (GO:0007269)3.46370317
63negative regulation of homotypic cell-cell adhesion (GO:0034111)3.44060028
64neurotransmitter transport (GO:0006836)3.43959275
65righting reflex (GO:0060013)3.43742139
66mitotic metaphase plate congression (GO:0007080)3.41051209
67response to histamine (GO:0034776)3.37526382
68adenosine receptor signaling pathway (GO:0001973)3.36193851
69regulation of sensory perception (GO:0051931)3.35993947
70regulation of sensory perception of pain (GO:0051930)3.35993947
71neuronal action potential propagation (GO:0019227)3.35938542
72neurotransmitter-gated ion channel clustering (GO:0072578)3.33940020
73negative regulation of neurotransmitter transport (GO:0051589)3.33111667
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32570787
75inner ear receptor cell development (GO:0060119)3.32027005
76negative regulation of heart contraction (GO:0045822)3.30395843
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29585205
78regulation of synaptic vesicle transport (GO:1902803)3.27376004
79epithelial cilium movement (GO:0003351)3.25335399
80mitotic G2/M transition checkpoint (GO:0044818)3.25045019
81regulation of integrin activation (GO:0033623)3.23722534
82presynaptic membrane organization (GO:0097090)3.23719417
83regulation of mitotic spindle organization (GO:0060236)3.23371350
84microtubule depolymerization (GO:0007019)3.22756280
85regulation of spindle organization (GO:0090224)3.22464299
86reflex (GO:0060004)3.22463268
87pyrimidine nucleobase catabolic process (GO:0006208)3.21710141
88dendritic spine morphogenesis (GO:0060997)3.21473215
89regulation of appetite (GO:0032098)3.20377148
90positive regulation of sodium ion transmembrane transport (GO:1902307)3.19939687
91regulation of synapse maturation (GO:0090128)3.19611991
92DNA strand renaturation (GO:0000733)3.18050145
93regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16992578
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12973501
95positive regulation of neurotransmitter secretion (GO:0001956)3.11425636
96amino acid import (GO:0043090)3.10259232
97behavioral response to cocaine (GO:0048148)3.10090756
98negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.09114725
99negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.08442095
100bone trabecula formation (GO:0060346)3.08173017
101glycosphingolipid biosynthetic process (GO:0006688)3.07967603
102transmission of nerve impulse (GO:0019226)3.07421132
103catecholamine transport (GO:0051937)3.07009887
104regulation of vesicle fusion (GO:0031338)3.06927253
105dendrite development (GO:0016358)3.06053601
106synaptic vesicle docking involved in exocytosis (GO:0016081)3.05204938
107regulation of neurotransmitter levels (GO:0001505)3.04522982
108kinetochore assembly (GO:0051382)3.03153840
109negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02010787
110polyketide metabolic process (GO:0030638)3.00548582
111doxorubicin metabolic process (GO:0044598)3.00548582
112daunorubicin metabolic process (GO:0044597)3.00548582
113synaptic transmission, dopaminergic (GO:0001963)3.00056810
114regulation of neuronal synaptic plasticity (GO:0048168)2.96891851
115fear response (GO:0042596)2.96253113
116single strand break repair (GO:0000012)2.96017192
117long-term synaptic potentiation (GO:0060291)2.95746621
118adult walking behavior (GO:0007628)2.95220842
119synaptic vesicle endocytosis (GO:0048488)2.94992435
120regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93174509
121neurotransmitter catabolic process (GO:0042135)2.90708554
122fibroblast migration (GO:0010761)2.90654869
123dentate gyrus development (GO:0021542)2.90337303
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90248167
125positive regulation of neurotransmitter transport (GO:0051590)2.89917248
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89859802
127metaphase plate congression (GO:0051310)2.89751900
128synaptic vesicle maturation (GO:0016188)2.89621579
129inner ear receptor stereocilium organization (GO:0060122)2.88642533
130regulation of neurological system process (GO:0031644)2.87878083
131positive regulation of synapse assembly (GO:0051965)2.87747617
132regulation of voltage-gated calcium channel activity (GO:1901385)2.86917592
133positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.85403822
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85136658
135limb development (GO:0060173)2.84389015
136appendage development (GO:0048736)2.84389015
137superoxide anion generation (GO:0042554)2.83999665
138regulation of postsynaptic membrane potential (GO:0060078)2.83216290
139response to parathyroid hormone (GO:0071107)2.83131029
140developmental pigmentation (GO:0048066)2.82584691
141regulation of synaptic transmission, glutamatergic (GO:0051966)2.82167152
142response to auditory stimulus (GO:0010996)2.81915677
143neurotransmitter biosynthetic process (GO:0042136)2.80597368
144platelet dense granule organization (GO:0060155)2.77790531
145synapse organization (GO:0050808)2.76902261
146regulation of dopamine metabolic process (GO:0042053)2.74769533
147regulation of catecholamine metabolic process (GO:0042069)2.74769533
148long-term memory (GO:0007616)2.73515202
149auditory receptor cell stereocilium organization (GO:0060088)2.73426498
150negative regulation of catecholamine secretion (GO:0033604)2.73266213
151regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71915815
152synaptic transmission (GO:0007268)2.71905942
153neuronal ion channel clustering (GO:0045161)2.71466097
154cGMP biosynthetic process (GO:0006182)2.70527501
155chromatin remodeling at centromere (GO:0031055)2.70510308
156positive regulation of catenin import into nucleus (GO:0035413)2.70340617
157CENP-A containing nucleosome assembly (GO:0034080)2.68820133
158leukocyte migration involved in inflammatory response (GO:0002523)2.68803929
159central nervous system projection neuron axonogenesis (GO:0021952)2.67828435
160regulation of platelet aggregation (GO:0090330)2.67554535
161regulation of neurotransmitter secretion (GO:0046928)2.67410408
162regulation of neurotransmitter transport (GO:0051588)2.66470325
163DNA double-strand break processing (GO:0000729)2.66284243
164behavioral defense response (GO:0002209)2.63236433
165behavioral fear response (GO:0001662)2.63236433
166G2 DNA damage checkpoint (GO:0031572)2.62853919
167regulation of clathrin-mediated endocytosis (GO:2000369)2.62199277
168negative regulation of platelet activation (GO:0010544)2.62183661
169cilium movement (GO:0003341)2.61914845
170mating behavior (GO:0007617)2.60645888
171membrane depolarization (GO:0051899)2.60612572
172regulation of synapse assembly (GO:0051963)2.60443121
173regulation of synaptic transmission, GABAergic (GO:0032228)2.60397393
174cerebral cortex radially oriented cell migration (GO:0021799)2.60277194
175pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59527943
176prepulse inhibition (GO:0060134)2.59516000
177membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59221348
178triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58875761
179regulation of developmental pigmentation (GO:0048070)2.58543551
180phagosome maturation (GO:0090382)2.58446883
181mitotic G2 DNA damage checkpoint (GO:0007095)2.58416078
182gamma-aminobutyric acid transport (GO:0015812)2.58085019
183negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.57451591
184regulation of neurotransmitter uptake (GO:0051580)2.57050891
185positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.55653079
186cGMP metabolic process (GO:0046068)2.55510814
187negative regulation of blood circulation (GO:1903523)2.54539179
188cardiolipin metabolic process (GO:0032048)2.52662682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73236805
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.56629254
3GBX2_23144817_ChIP-Seq_PC3_Human4.04756188
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.32973467
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.89493896
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76717454
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66516076
8TAF15_26573619_Chip-Seq_HEK293_Human2.64962795
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62294431
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51040391
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45019856
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.44739070
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41703167
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.30430266
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28886156
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28886156
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19859902
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.17379736
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13560008
20REST_21632747_ChIP-Seq_MESCs_Mouse2.04241761
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03634902
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01402745
23SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01354406
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99824179
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98492625
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98052321
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97153576
28P300_19829295_ChIP-Seq_ESCs_Human1.94660451
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93855038
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.91634816
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90957573
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88561977
33AR_21572438_ChIP-Seq_LNCaP_Human1.86070886
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.85684260
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84565869
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84392127
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83790199
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83004784
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81174306
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.80562956
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.80099577
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79693788
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.79556800
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.78457207
45DROSHA_22980978_ChIP-Seq_HELA_Human1.75687751
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71877650
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.70332504
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67816308
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66284536
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.65995120
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63170244
52ELK1_19687146_ChIP-ChIP_HELA_Human1.62973047
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.60027688
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.59529617
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59097041
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58855225
57ZNF274_21170338_ChIP-Seq_K562_Hela1.55601927
58BCAT_22108803_ChIP-Seq_LS180_Human1.54655310
59FUS_26573619_Chip-Seq_HEK293_Human1.53584073
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51017391
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48916694
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48768232
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47778864
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.47538136
65MYC_18940864_ChIP-ChIP_HL60_Human1.46925903
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.46176325
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45862832
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.45819548
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.44206285
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44177015
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43798582
72P53_22387025_ChIP-Seq_ESCs_Mouse1.42883686
73* HTT_18923047_ChIP-ChIP_STHdh_Human1.42305681
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.41095662
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40316760
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40206878
77RNF2_27304074_Chip-Seq_NSC_Mouse1.39890217
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39731744
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.39119873
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37455267
81AR_25329375_ChIP-Seq_VCAP_Human1.37079889
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35006599
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33845948
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33701783
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33646762
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33221604
87ER_23166858_ChIP-Seq_MCF-7_Human1.32510862
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.31601131
89TP53_18474530_ChIP-ChIP_U2OS_Human1.31453157
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30809136
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30669081
92STAT3_23295773_ChIP-Seq_U87_Human1.30071286
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28925473
94EWS_26573619_Chip-Seq_HEK293_Human1.28803145
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27977710
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27508660
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26648695
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.26508916
99VDR_22108803_ChIP-Seq_LS180_Human1.26368644
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26142249
101IGF1R_20145208_ChIP-Seq_DFB_Human1.26138720
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.25739582
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25450989
104RUNX2_22187159_ChIP-Seq_PCA_Human1.23662099
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23097451
106P300_18555785_Chip-Seq_ESCs_Mouse1.22952947
107ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22392484
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21893537
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.21563150
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20847351
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.20664854
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.17991993
113* TCF4_23295773_ChIP-Seq_U87_Human1.17728961
114IRF1_19129219_ChIP-ChIP_H3396_Human1.17424698
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16523287
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16355197
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15121694
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14722634
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.14605161
120* KDM2B_26808549_Chip-Seq_REH_Human1.13819735
121RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12165143
122SCL_19346495_ChIP-Seq_HPC-7_Human1.11720008
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11563322
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11563322
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11196801
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11000295
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.10963711
128CTCF_18555785_Chip-Seq_ESCs_Mouse1.09549045
129AHR_22903824_ChIP-Seq_MCF-7_Human1.09434625
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09344441
131NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09344441
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.08921413
133TCF4_22108803_ChIP-Seq_LS180_Human1.08865565
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08767000
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08597170
136SALL1_21062744_ChIP-ChIP_HESCs_Human1.08261764
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07991366
138JUN_21703547_ChIP-Seq_K562_Human1.06536892
139SALL4_22934838_ChIP-ChIP_CD34+_Human1.05554801
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04771534
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00608401
142KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00560426
143SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98701439
144SOX2_19829295_ChIP-Seq_ESCs_Human0.97389637
145NANOG_19829295_ChIP-Seq_ESCs_Human0.97389637
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95304754
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94919598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.83326815
2MP0003880_abnormal_central_pattern5.11322144
3MP0004859_abnormal_synaptic_plasticity4.29588073
4MP0010030_abnormal_orbit_morphology4.07900169
5MP0000372_irregular_coat_pigmentation3.68889015
6MP0002938_white_spotting3.47389908
7MP0003011_delayed_dark_adaptation3.41379821
8MP0003635_abnormal_synaptic_transmissio3.34677215
9MP0009745_abnormal_behavioral_response3.24975491
10MP0005248_abnormal_Harderian_gland3.22648420
11MP0001968_abnormal_touch/_nociception3.12977744
12MP0006276_abnormal_autonomic_nervous3.03418157
13MP0001486_abnormal_startle_reflex2.93455408
14MP0009046_muscle_twitch2.92689090
15MP0002736_abnormal_nociception_after2.91803688
16MP0002064_seizures2.88678524
17MP0005464_abnormal_platelet_physiology2.86243749
18MP0001501_abnormal_sleep_pattern2.76536969
19MP0005645_abnormal_hypothalamus_physiol2.74165159
20MP0001188_hyperpigmentation2.70230246
21MP0001529_abnormal_vocalization2.68312343
22MP0002063_abnormal_learning/memory/cond2.65230643
23MP0002572_abnormal_emotion/affect_behav2.63106966
24MP0001440_abnormal_grooming_behavior2.49433745
25MP0002102_abnormal_ear_morphology2.44932161
26MP0003122_maternal_imprinting2.41788977
27MP0002272_abnormal_nervous_system2.39620624
28MP0004142_abnormal_muscle_tone2.27221653
29MP0002735_abnormal_chemical_nociception2.25912830
30MP0005670_abnormal_white_adipose2.24445420
31MP0002067_abnormal_sensory_capabilities2.19221417
32MP0002653_abnormal_ependyma_morphology2.15347666
33MP0005423_abnormal_somatic_nervous2.12289173
34MP0005174_abnormal_tail_pigmentation2.03555623
35MP0002876_abnormal_thyroid_physiology2.00038226
36MP0005386_behavior/neurological_phenoty1.96213068
37MP0004924_abnormal_behavior1.96213068
38MP0005646_abnormal_pituitary_gland1.92733030
39MP0002184_abnormal_innervation1.89963573
40MP0004742_abnormal_vestibular_system1.88259840
41MP0002557_abnormal_social/conspecific_i1.88197302
42MP0002734_abnormal_mechanical_nocicepti1.81742212
43MP0000778_abnormal_nervous_system1.81200087
44MP0002095_abnormal_skin_pigmentation1.80506467
45MP0003787_abnormal_imprinting1.72474088
46MP0008058_abnormal_DNA_repair1.67605954
47MP0001879_abnormal_lymphatic_vessel1.66760160
48MP0004381_abnormal_hair_follicle1.65149865
49MP0001970_abnormal_pain_threshold1.63353083
50MP0001905_abnormal_dopamine_level1.62769088
51MP0002733_abnormal_thermal_nociception1.59998787
52MP0003879_abnormal_hair_cell1.59443983
53MP0001502_abnormal_circadian_rhythm1.56986202
54MP0004270_analgesia1.53612992
55MP0005084_abnormal_gallbladder_morpholo1.48805785
56MP0008961_abnormal_basal_metabolism1.36728484
57MP0003718_maternal_effect1.34915687
58MP0000569_abnormal_digit_pigmentation1.33995989
59MP0008875_abnormal_xenobiotic_pharmacok1.33103042
60MP0002837_dystrophic_cardiac_calcinosis1.32130302
61MP0002822_catalepsy1.32015315
62MP0000534_abnormal_ureter_morphology1.31229706
63MP0000955_abnormal_spinal_cord1.28455961
64MP0004215_abnormal_myocardial_fiber1.27877527
65MP0002751_abnormal_autonomic_nervous1.27315796
66MP0006054_spinal_hemorrhage1.25606607
67MP0001963_abnormal_hearing_physiology1.25522583
68MP0004858_abnormal_nervous_system1.25328181
69MP0003121_genomic_imprinting1.23073987
70MP0002066_abnormal_motor_capabilities/c1.22137705
71MP0008775_abnormal_heart_ventricle1.19907785
72MP0008872_abnormal_physiological_respon1.19580750
73MP0003937_abnormal_limbs/digits/tail_de1.19486154
74MP0002882_abnormal_neuron_morphology1.17357752
75MP0003950_abnormal_plasma_membrane1.11415375
76MP0000566_synostosis1.08830548
77MP0001661_extended_life_span1.08537036
78MP0001485_abnormal_pinna_reflex1.06716601
79MP0003119_abnormal_digestive_system1.06214169
80MP0005171_absent_coat_pigmentation1.05503520
81MP0008569_lethality_at_weaning1.05487347
82MP0004811_abnormal_neuron_physiology1.05487297
83MP0005535_abnormal_body_temperature1.05330625
84MP0002233_abnormal_nose_morphology1.04475229
85MP0001984_abnormal_olfaction1.04452663
86MP0000026_abnormal_inner_ear1.03903700
87MP0005083_abnormal_biliary_tract1.03046125
88MP0003938_abnormal_ear_development1.02728657
89MP0000230_abnormal_systemic_arterial1.02432539
90MP0005551_abnormal_eye_electrophysiolog1.01725609
91MP0009765_abnormal_xenobiotic_induced1.01339275
92MP0002697_abnormal_eye_size1.01233150
93MP0000631_abnormal_neuroendocrine_gland0.99930684
94MP0005623_abnormal_meninges_morphology0.98555044
95MP0003111_abnormal_nucleus_morphology0.98444563
96MP0002069_abnormal_eating/drinking_beha0.96801692
97MP0006292_abnormal_olfactory_placode0.96695615
98MP0005075_abnormal_melanosome_morpholog0.95286012
99MP0009780_abnormal_chondrocyte_physiolo0.91914896
100MP0002163_abnormal_gland_morphology0.91473067
101MP0005409_darkened_coat_color0.88462553
102MP0006072_abnormal_retinal_apoptosis0.87747784
103MP0000678_abnormal_parathyroid_gland0.87703474
104MP0001664_abnormal_digestion0.87527231
105MP0005379_endocrine/exocrine_gland_phen0.86554084
106MP0002752_abnormal_somatic_nervous0.86324158
107MP0001986_abnormal_taste_sensitivity0.85318035
108MP0008004_abnormal_stomach_pH0.84834964
109MP0004133_heterotaxia0.84114706
110MP0000427_abnormal_hair_cycle0.82569625
111MP0004484_altered_response_of0.81870410
112MP0003633_abnormal_nervous_system0.80859283
113MP0009764_decreased_sensitivity_to0.80238259
114MP0002295_abnormal_pulmonary_circulatio0.79266989
115MP0002090_abnormal_vision0.78983519
116MP0002277_abnormal_respiratory_mucosa0.78310700
117MP0001177_atelectasis0.77997742
118MP0002152_abnormal_brain_morphology0.76291158
119MP0003186_abnormal_redox_activity0.76240180
120MP0008874_decreased_physiological_sensi0.75152351
121MP0003077_abnormal_cell_cycle0.74788291
122MP0003638_abnormal_response/metabolism_0.73991549
123MP0001286_abnormal_eye_development0.73757361
124MP0003631_nervous_system_phenotype0.73544495
125MP0005410_abnormal_fertilization0.72419707
126MP0004036_abnormal_muscle_relaxation0.72003652
127MP0010386_abnormal_urinary_bladder0.71699380
128MP0003195_calcinosis0.71598922
129MP0003690_abnormal_glial_cell0.70068555
130MP0002909_abnormal_adrenal_gland0.69758890
131MP0005377_hearing/vestibular/ear_phenot0.68108860
132MP0003878_abnormal_ear_physiology0.68108860
133MP0002075_abnormal_coat/hair_pigmentati0.67463185
134MP0005266_abnormal_metabolism0.66223291
135MP0005620_abnormal_muscle_contractility0.65309453
136MP0004883_abnormal_blood_vessel0.65081218
137MP0004510_myositis0.64716926
138MP0003861_abnormal_nervous_system0.64140057
139MP0005595_abnormal_vascular_smooth0.63895813
140MP0002111_abnormal_tail_morphology0.63708691
141MP0005253_abnormal_eye_physiology0.63276699
142MP0001346_abnormal_lacrimal_gland0.62893961
143MP0004084_abnormal_cardiac_muscle0.62884533
144MP0002932_abnormal_joint_morphology0.62444223
145MP0009697_abnormal_copulation0.62199317
146MP0002229_neurodegeneration0.60729553
147MP0002282_abnormal_trachea_morphology0.60450077
148MP0005499_abnormal_olfactory_system0.60276853
149MP0005394_taste/olfaction_phenotype0.60276853
150MP0004085_abnormal_heartbeat0.59265035
151MP0008932_abnormal_embryonic_tissue0.59171301
152MP0001293_anophthalmia0.59027221
153MP0003646_muscle_fatigue0.58695120
154MP0005395_other_phenotype0.57434043
155MP0005195_abnormal_posterior_eye0.57009970
156MP0003942_abnormal_urinary_system0.55902253
157MP0004885_abnormal_endolymph0.54285772
158MP0003075_altered_response_to0.52837559
159MP0010094_abnormal_chromosome_stability0.50897418
160MP0009379_abnormal_foot_pigmentation0.50782721
161MP0005310_abnormal_salivary_gland0.50770662
162MP0009250_abnormal_appendicular_skeleto0.50751887
163MP0003632_abnormal_nervous_system0.50086268

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.47751239
2Oligodactyly (hands) (HP:0001180)4.76263107
3Increased mean platelet volume (HP:0011877)4.73833648
4Febrile seizures (HP:0002373)4.67343143
5Focal seizures (HP:0007359)4.59054805
6Prolonged bleeding time (HP:0003010)4.46709624
7Menorrhagia (HP:0000132)4.29244884
8Split foot (HP:0001839)4.19805608
9Abnormal platelet volume (HP:0011876)4.17983956
10Petechiae (HP:0000967)3.93626032
11Epileptic encephalopathy (HP:0200134)3.91840458
12Atonic seizures (HP:0010819)3.85797753
13Severe visual impairment (HP:0001141)3.83085553
14Pancreatic cysts (HP:0001737)3.82222767
15Limb dystonia (HP:0002451)3.76686728
16Generalized tonic-clonic seizures (HP:0002069)3.72305741
17True hermaphroditism (HP:0010459)3.66407707
18Anencephaly (HP:0002323)3.62536645
19Hyperventilation (HP:0002883)3.59199791
20Purpura (HP:0000979)3.56014893
21Poikilocytosis (HP:0004447)3.52080210
22Pancreatic fibrosis (HP:0100732)3.50415671
23Agitation (HP:0000713)3.41181071
24Visual hallucinations (HP:0002367)3.40699150
25Abnormal hair whorl (HP:0010721)3.32578896
26Gingival bleeding (HP:0000225)3.29967976
27Progressive cerebellar ataxia (HP:0002073)3.29488040
28Anophthalmia (HP:0000528)3.25337608
29Myokymia (HP:0002411)3.22884222
30Oligodactyly (HP:0012165)3.18989854
31Protruding tongue (HP:0010808)3.14960321
32Partial duplication of the phalanx of hand (HP:0009999)3.13654698
33Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06388211
34Thyroid-stimulating hormone excess (HP:0002925)3.05245338
35Broad-based gait (HP:0002136)3.00788304
36Absence seizures (HP:0002121)3.00540366
37Fetal akinesia sequence (HP:0001989)2.99124582
38Dialeptic seizures (HP:0011146)2.98317081
39Hypoplasia of the capital femoral epiphysis (HP:0003090)2.95823967
40Abnormal lung lobation (HP:0002101)2.93281798
41Abnormality of calcium-phosphate metabolism (HP:0100530)2.86082052
42Parakeratosis (HP:0001036)2.82416758
43Polyphagia (HP:0002591)2.80551741
44Drooling (HP:0002307)2.79641839
45Excessive salivation (HP:0003781)2.79641839
46Fair hair (HP:0002286)2.79330756
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.72847901
48Inappropriate behavior (HP:0000719)2.71344552
49Epistaxis (HP:0000421)2.69987897
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.68399452
51Abnormality of alanine metabolism (HP:0010916)2.68399452
52Hyperalaninemia (HP:0003348)2.68399452
53Exotropia (HP:0000577)2.68006865
54Absent thumb (HP:0009777)2.64201456
55Gaze-evoked nystagmus (HP:0000640)2.63274182
56Absent hand (HP:0004050)2.62486854
57Mutism (HP:0002300)2.61174905
58Anxiety (HP:0000739)2.59449380
59Failure to thrive in infancy (HP:0001531)2.58227572
60Generalized hypopigmentation of hair (HP:0011358)2.57460485
6111 pairs of ribs (HP:0000878)2.56018140
62Partial duplication of thumb phalanx (HP:0009944)2.55495293
63Generalized myoclonic seizures (HP:0002123)2.51366374
64Upper limb muscle weakness (HP:0003484)2.48680208
65Hyperphosphatemia (HP:0002905)2.48235864
66Cystic liver disease (HP:0006706)2.47725718
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.47372387
68Annular pancreas (HP:0001734)2.46319158
69Esotropia (HP:0000565)2.44803664
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43380920
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.43380920
72Reticulocytopenia (HP:0001896)2.42111983
73Akinesia (HP:0002304)2.41888079
74Abnormality of macular pigmentation (HP:0008002)2.41373871
75Poor suck (HP:0002033)2.39768540
76Depression (HP:0000716)2.38496366
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.34902200
78Broad foot (HP:0001769)2.34621193
79Occipital encephalocele (HP:0002085)2.33572825
80Abnormality of the parietal bone (HP:0002696)2.32339854
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.32283835
82Absent/shortened dynein arms (HP:0200106)2.32283835
83Cortical dysplasia (HP:0002539)2.32223523
84Absent epiphyses (HP:0010577)2.31843157
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.31843157
86Gait imbalance (HP:0002141)2.30884367
87Septo-optic dysplasia (HP:0100842)2.28673545
88Ectopic kidney (HP:0000086)2.28309362
89Horizontal nystagmus (HP:0000666)2.28204189
90Medial flaring of the eyebrow (HP:0010747)2.27810368
91Abnormal auditory evoked potentials (HP:0006958)2.25250427
92Irregular epiphyses (HP:0010582)2.23065614
93Abnormal platelet function (HP:0011869)2.22979224
94Impaired platelet aggregation (HP:0003540)2.22979224
95Abnormal ciliary motility (HP:0012262)2.22581843
96Small intestinal stenosis (HP:0012848)2.22434436
97Duodenal stenosis (HP:0100867)2.22434436
98Poor eye contact (HP:0000817)2.22181978
99Congenital sensorineural hearing impairment (HP:0008527)2.20942035
100Increased IgM level (HP:0003496)2.20385541
101Abnormality of salivation (HP:0100755)2.17501641
102Abnormality of incisor morphology (HP:0011063)2.17366362
103Absent speech (HP:0001344)2.16973284
104Abnormal eating behavior (HP:0100738)2.15702641
105Male pseudohermaphroditism (HP:0000037)2.15656210
106Sloping forehead (HP:0000340)2.15620504
107Sclerocornea (HP:0000647)2.14387562
108Incomplete penetrance (HP:0003829)2.13984689
109Blue irides (HP:0000635)2.11380427
110Small hand (HP:0200055)2.11330685
111Stenosis of the external auditory canal (HP:0000402)2.10444352
112Epileptiform EEG discharges (HP:0011182)2.09262930
113Hypoplasia of the radius (HP:0002984)2.09237988
114Short tibia (HP:0005736)2.07641999
115Hypoplastic pelvis (HP:0008839)2.07625909
116Optic nerve hypoplasia (HP:0000609)2.03262532
117Tetany (HP:0001281)2.03061521
118Acanthocytosis (HP:0001927)2.02789084
119Disproportionate short-trunk short stature (HP:0003521)2.01309011
120Nephrogenic diabetes insipidus (HP:0009806)2.00587828
121Colon cancer (HP:0003003)1.98177692
122Abnormal respiratory motile cilium morphology (HP:0005938)1.97550563
123Abnormal respiratory epithelium morphology (HP:0012253)1.97550563
124Coronal craniosynostosis (HP:0004440)1.97225535
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.97068133
126EEG with generalized epileptiform discharges (HP:0011198)1.95447191
127Abnormality of the heme biosynthetic pathway (HP:0010472)1.94708199
128Congenital primary aphakia (HP:0007707)1.94634240
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94630409
130Supranuclear gaze palsy (HP:0000605)1.93489520
131Hypoplasia of the pons (HP:0012110)1.92790221
132Decreased testicular size (HP:0008734)1.92600507
133Narrow nasal bridge (HP:0000446)1.92471416
134Esophageal atresia (HP:0002032)1.89647762
135Hemiparesis (HP:0001269)1.89100931
136Missing ribs (HP:0000921)1.88761544
137Widely spaced teeth (HP:0000687)1.88468622
138Abnormality of the duodenum (HP:0002246)1.88115145
139Bicornuate uterus (HP:0000813)1.86976976
140Psychosis (HP:0000709)1.86795496
141Morphological abnormality of the pyramidal tract (HP:0002062)1.86447461
142Intellectual disability, moderate (HP:0002342)1.86151999
143Increased circulating renin level (HP:0000848)1.86096686
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.85911830
145Nephronophthisis (HP:0000090)1.85841359
146Abnormality of the corticospinal tract (HP:0002492)1.85812127
147Hypsarrhythmia (HP:0002521)1.85246003
148Cone-rod dystrophy (HP:0000548)1.84592110
149Inability to walk (HP:0002540)1.84587242
150Broad nasal tip (HP:0000455)1.84092857
151Congenital hepatic fibrosis (HP:0002612)1.83472181
152Triphalangeal thumb (HP:0001199)1.83008627
153Long clavicles (HP:0000890)1.82988604
154Postural instability (HP:0002172)1.81766514
155Thrombocytosis (HP:0001894)1.81571146
156Abnormal pancreas size (HP:0012094)1.81487654
157Pheochromocytoma (HP:0002666)1.81430618
158Abnormality of the pons (HP:0007361)1.81414493
159Truncal ataxia (HP:0002078)1.81303123
160Conical tooth (HP:0000698)1.81242093
161Conjunctival telangiectasia (HP:0000524)1.81120777
162Alveolar cell carcinoma (HP:0006519)1.79493313
163Genital tract atresia (HP:0001827)1.79426693
164Amblyopia (HP:0000646)1.78441778
165Dysmetria (HP:0001310)1.78076398
166Lissencephaly (HP:0001339)1.77839740
167Vaginal atresia (HP:0000148)1.77173161
168Torticollis (HP:0000473)1.76254385
169Ankle clonus (HP:0011448)1.75983820
170Hypoplastic iliac wings (HP:0002866)1.75949823
171Hip dysplasia (HP:0001385)1.75310731
172Severe Myopia (HP:0011003)1.75180757
173Chronic hepatic failure (HP:0100626)1.74953296
174Generalized aminoaciduria (HP:0002909)1.74638137
175Progressive inability to walk (HP:0002505)1.74547504
176Mild short stature (HP:0003502)1.73306240
177Hypothermia (HP:0002045)1.73097181
178Abnormal social behavior (HP:0012433)1.72605850
179Impaired social interactions (HP:0000735)1.72605850
180Coarctation of aorta (HP:0001680)1.71944242
181Synostosis involving the elbow (HP:0003938)1.71759559
182Humeroradial synostosis (HP:0003041)1.71759559
183Hypoventilation (HP:0002791)1.71444003
184Preaxial hand polydactyly (HP:0001177)1.70466802
185Abnormality of binocular vision (HP:0011514)1.69855535
186Diplopia (HP:0000651)1.69855535
187Large earlobe (HP:0009748)1.68991361
188Dysdiadochokinesis (HP:0002075)1.65587991
189Aplasia cutis congenita (HP:0001057)1.64048820
190Abnormality of dental color (HP:0011073)1.63546009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.93769733
2NTRK34.08732206
3CASK3.86658502
4MAP3K123.65028052
5EPHB23.29162269
6MARK12.94757871
7MAP2K72.83013141
8TNIK2.71827356
9ACVR1B2.55983627
10ZAK2.46180799
11MAP3K42.40863458
12CDC72.32943225
13TRIM282.32163016
14EPHA42.29184987
15TYRO32.16802278
16PRPF4B2.05272031
17MAPK132.01390740
18MINK11.94421681
19PLK21.94174473
20SIK21.94147548
21PNCK1.93652763
22DYRK21.92675956
23MAP4K21.82239988
24SIK31.78089509
25GRK51.76004092
26NTRK21.73343355
27NEK21.72986439
28MAP2K41.68797119
29MAP3K91.67727461
30PIK3CG1.65944773
31PIK3CA1.62418102
32BMPR21.57827166
33TTK1.56585505
34ADRBK21.53546258
35BRSK21.49069317
36MST41.47873039
37TNK21.43458370
38PLK31.39055271
39FGR1.35058538
40CAMK2A1.31527524
41MAP3K131.29986794
42LATS21.28706331
43PRKCG1.28631894
44SGK21.24753333
45RIPK41.24439204
46FES1.21504555
47MYLK1.19659716
48OBSCN1.13873665
49DAPK21.10894455
50OXSR11.10041171
51BMX1.09929969
52TAF11.08533695
53PRKCE1.06912033
54CDK191.06864568
55STK31.05957701
56FRK1.05391258
57CDK51.04303483
58MAP3K141.03993597
59IRAK21.03726244
60EIF2AK21.02833953
61STK240.98813549
62DAPK10.98730626
63PTK2B0.98260221
64VRK10.97352084
65PLK10.96158861
66GRK70.95028453
67SGK4940.94226645
68SGK2230.94226645
69BMPR1B0.92092900
70CHEK20.86271395
71TGFBR10.85627785
72IRAK30.85241004
73NTRK10.84763813
74MKNK10.84689774
75PLK40.84462467
76DYRK30.83131715
77MUSK0.83019920
78IRAK10.82765409
79SGK10.81955846
80CSNK1G20.80650569
81NME10.79511311
82ERBB30.79170624
83WNK30.78631792
84KSR10.77756880
85CAMK10.77339022
86PKN10.73057567
87IRAK40.70476078
88PAK60.70095105
89TLK10.69760029
90TXK0.68629902
91PHKG20.67886756
92PHKG10.67886756
93BCR0.67835528
94ADRBK10.66035516
95CAMK2B0.65906811
96DYRK1A0.65569593
97BTK0.65427515
98ILK0.64182347
99TEC0.63810331
100NEK60.62543508
101SGK30.59314479
102YES10.58161911
103PAK30.57410950
104STK110.56252073
105STK38L0.54939467
106ATR0.53394831
107INSRR0.53164520
108ATM0.52966299
109CCNB10.52806314
110CAMK40.51297914
111DDR20.51071785
112PBK0.50954029
113VRK20.49635703
114AURKB0.48908650
115BCKDK0.48897754
116EPHA30.48436441
117FGFR20.48194774
118PRKACA0.46835764
119SYK0.46052444
120RPS6KA50.45946983
121CAMK2D0.45919366
122AKT30.45268633
123PINK10.44794886
124GRK10.44618604
125CAMK2G0.44056118
126ARAF0.44004773
127PRKCB0.43086002
128CDK80.42048514
129BLK0.41369372
130SRPK10.41209747
131PRKCZ0.40975505
132CDK30.40307140
133UHMK10.40179608
134CSNK1G30.39950998
135BRSK10.39500896
136PRKG10.39484905
137PRKCQ0.38907419
138FLT30.38852689
139CSNK1D0.38058929
140FYN0.38046580
141RPS6KB10.37921551
142PRKCA0.37785553
143PRKCH0.37720977
144AURKA0.36507112
145CSNK1A10.36369206
146CSNK1E0.34011183
147CAMK1G0.33947360
148MAP3K70.33582626
149LYN0.33516670
150MAPKAPK50.33222059
151WNK10.33003917
152EIF2AK10.32732216
153PRKACB0.27384198
154DAPK30.24921570
155CHEK10.23876220
156FGFR10.23847202
157RPS6KA30.23823514

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.78108477
2Caffeine metabolism_Homo sapiens_hsa002323.68514325
3Non-homologous end-joining_Homo sapiens_hsa034503.39974436
4Synaptic vesicle cycle_Homo sapiens_hsa047213.25013546
5Nitrogen metabolism_Homo sapiens_hsa009102.99881015
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82109075
7Morphine addiction_Homo sapiens_hsa050322.74026947
8GABAergic synapse_Homo sapiens_hsa047272.47793924
9Circadian entrainment_Homo sapiens_hsa047132.45709909
10Glutamatergic synapse_Homo sapiens_hsa047242.39117378
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33490048
12Platelet activation_Homo sapiens_hsa046112.28398020
13Amphetamine addiction_Homo sapiens_hsa050312.27870687
14Collecting duct acid secretion_Homo sapiens_hsa049662.20441592
15Long-term potentiation_Homo sapiens_hsa047202.19335772
16Olfactory transduction_Homo sapiens_hsa047402.16759333
17* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11311043
18Serotonergic synapse_Homo sapiens_hsa047262.06637233
19Insulin secretion_Homo sapiens_hsa049111.95104789
20Fanconi anemia pathway_Homo sapiens_hsa034601.92697418
21Taste transduction_Homo sapiens_hsa047421.87610079
22Ribosome_Homo sapiens_hsa030101.86282507
23Cocaine addiction_Homo sapiens_hsa050301.83531674
24beta-Alanine metabolism_Homo sapiens_hsa004101.83096293
25Dopaminergic synapse_Homo sapiens_hsa047281.78814318
26Salivary secretion_Homo sapiens_hsa049701.75420233
27Cholinergic synapse_Homo sapiens_hsa047251.75329985
28* Calcium signaling pathway_Homo sapiens_hsa040201.68971152
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66228018
30Renin secretion_Homo sapiens_hsa049241.62389293
31Long-term depression_Homo sapiens_hsa047301.62166301
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.57653790
33Oxidative phosphorylation_Homo sapiens_hsa001901.53344637
34Rheumatoid arthritis_Homo sapiens_hsa053231.47100599
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43680353
36Basal transcription factors_Homo sapiens_hsa030221.42448452
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31991230
38Gastric acid secretion_Homo sapiens_hsa049711.31937207
39TGF-beta signaling pathway_Homo sapiens_hsa043501.31170916
40Vibrio cholerae infection_Homo sapiens_hsa051101.29854865
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28943334
42Homologous recombination_Homo sapiens_hsa034401.27360648
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27065781
44Axon guidance_Homo sapiens_hsa043601.24644063
45Arachidonic acid metabolism_Homo sapiens_hsa005901.22177798
46African trypanosomiasis_Homo sapiens_hsa051431.19789247
47Oxytocin signaling pathway_Homo sapiens_hsa049211.18829600
48ECM-receptor interaction_Homo sapiens_hsa045121.17583499
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17377907
50Type I diabetes mellitus_Homo sapiens_hsa049401.17328730
51Alzheimers disease_Homo sapiens_hsa050101.15960767
52Systemic lupus erythematosus_Homo sapiens_hsa053221.15762909
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14885258
54Tyrosine metabolism_Homo sapiens_hsa003501.14488589
55Base excision repair_Homo sapiens_hsa034101.12244475
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11988417
57Tryptophan metabolism_Homo sapiens_hsa003801.11889445
58Phagosome_Homo sapiens_hsa041451.08999144
59cAMP signaling pathway_Homo sapiens_hsa040241.08938254
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06512648
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06000342
62Parkinsons disease_Homo sapiens_hsa050121.03891298
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02821356
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01228001
65Graft-versus-host disease_Homo sapiens_hsa053321.01106392
66Phototransduction_Homo sapiens_hsa047440.97439687
67GnRH signaling pathway_Homo sapiens_hsa049120.95262991
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95065351
69Linoleic acid metabolism_Homo sapiens_hsa005910.94722664
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93632596
71Cardiac muscle contraction_Homo sapiens_hsa042600.92368143
72Gap junction_Homo sapiens_hsa045400.90611888
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.88955904
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87852509
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87354169
76ErbB signaling pathway_Homo sapiens_hsa040120.87186417
77Glycerolipid metabolism_Homo sapiens_hsa005610.86351023
78Melanogenesis_Homo sapiens_hsa049160.83888699
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81526838
80Cell cycle_Homo sapiens_hsa041100.80544297
81Retinol metabolism_Homo sapiens_hsa008300.78720603
82Basal cell carcinoma_Homo sapiens_hsa052170.77832706
83One carbon pool by folate_Homo sapiens_hsa006700.76008646
84Type II diabetes mellitus_Homo sapiens_hsa049300.74813745
85Dorso-ventral axis formation_Homo sapiens_hsa043200.73878824
86Fatty acid degradation_Homo sapiens_hsa000710.73626845
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73341161
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73194526
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73145008
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70994217
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.70633030
92Hippo signaling pathway_Homo sapiens_hsa043900.70459339
93RNA transport_Homo sapiens_hsa030130.68811605
94Estrogen signaling pathway_Homo sapiens_hsa049150.68667661
95Allograft rejection_Homo sapiens_hsa053300.68373076
96Mismatch repair_Homo sapiens_hsa034300.67691474
97Huntingtons disease_Homo sapiens_hsa050160.65968048
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65640976
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63745818
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63294489
101Chemical carcinogenesis_Homo sapiens_hsa052040.62846471
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62715771
103Pyruvate metabolism_Homo sapiens_hsa006200.62679438
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62099288
105MAPK signaling pathway_Homo sapiens_hsa040100.61083362
106Notch signaling pathway_Homo sapiens_hsa043300.58661271
107Sulfur relay system_Homo sapiens_hsa041220.56572194
108Glioma_Homo sapiens_hsa052140.56334361
109RNA polymerase_Homo sapiens_hsa030200.54769814
110Ovarian steroidogenesis_Homo sapiens_hsa049130.54710798
111p53 signaling pathway_Homo sapiens_hsa041150.53692863
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52929879
113RNA degradation_Homo sapiens_hsa030180.52880486
114Wnt signaling pathway_Homo sapiens_hsa043100.51595196
115Propanoate metabolism_Homo sapiens_hsa006400.51195031
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51040889
117Complement and coagulation cascades_Homo sapiens_hsa046100.50398796
118Ras signaling pathway_Homo sapiens_hsa040140.49451241
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48496030
120Dilated cardiomyopathy_Homo sapiens_hsa054140.47499357
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.47252891
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46909453
123Tuberculosis_Homo sapiens_hsa051520.45771236
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45665720
125Ether lipid metabolism_Homo sapiens_hsa005650.45247347
126Fatty acid biosynthesis_Homo sapiens_hsa000610.44271568
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.43931586
128Arginine and proline metabolism_Homo sapiens_hsa003300.42675500
129Chemokine signaling pathway_Homo sapiens_hsa040620.41881232
130Choline metabolism in cancer_Homo sapiens_hsa052310.41170012
131Fatty acid elongation_Homo sapiens_hsa000620.41111829
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40312289
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40082644
134Autoimmune thyroid disease_Homo sapiens_hsa053200.39825194
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.39636179
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39081151
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38888953
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38883368
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38326534
140Prion diseases_Homo sapiens_hsa050200.38111872
141Butanoate metabolism_Homo sapiens_hsa006500.37810389
142Thyroid hormone synthesis_Homo sapiens_hsa049180.36439689
143Pancreatic secretion_Homo sapiens_hsa049720.36145618
144Salmonella infection_Homo sapiens_hsa051320.35496189
145TNF signaling pathway_Homo sapiens_hsa046680.35282985
146Hedgehog signaling pathway_Homo sapiens_hsa043400.34107773
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.33206854
148Inositol phosphate metabolism_Homo sapiens_hsa005620.33188317
149Alcoholism_Homo sapiens_hsa050340.31435389
150Rap1 signaling pathway_Homo sapiens_hsa040150.30595561
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30011170
152Sphingolipid metabolism_Homo sapiens_hsa006000.29135036
153Oocyte meiosis_Homo sapiens_hsa041140.28827006
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28793313
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26109444
156Osteoclast differentiation_Homo sapiens_hsa043800.24631512
157Melanoma_Homo sapiens_hsa052180.24383901

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