TRIB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.15348322
2embryonic process involved in female pregnancy (GO:0060136)4.24220700
3cellular extravasation (GO:0045123)3.90567332
4regulation of interleukin-8 biosynthetic process (GO:0045414)3.80514209
5positive regulation of p38MAPK cascade (GO:1900745)3.80369668
6hemidesmosome assembly (GO:0031581)3.47243488
7detection of molecule of bacterial origin (GO:0032490)3.46107790
8neutrophil activation involved in immune response (GO:0002283)3.41522352
9negative regulation of erythrocyte differentiation (GO:0045647)3.35279614
10negative regulation of interleukin-8 production (GO:0032717)3.29837924
11regulation of cholesterol homeostasis (GO:2000188)3.25958968
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21771411
13germinal center formation (GO:0002467)3.17208123
14peptidyl-glutamic acid carboxylation (GO:0017187)3.15773742
15protein carboxylation (GO:0018214)3.15773742
16lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12495268
17growth hormone receptor signaling pathway (GO:0060396)3.06955098
18regulation of p38MAPK cascade (GO:1900744)3.05463833
19regulation of T-helper 2 cell differentiation (GO:0045628)3.01333765
20neutrophil mediated immunity (GO:0002446)2.99638323
21mRNA transcription (GO:0009299)2.96759826
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92304395
23detection of other organism (GO:0098543)2.91084716
24skin morphogenesis (GO:0043589)2.90288323
25positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.89074667
26negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79399017
27ovulation (GO:0030728)2.79039827
28negative regulation of protein autophosphorylation (GO:0031953)2.78274205
29T-helper 1 type immune response (GO:0042088)2.77139220
30desmosome organization (GO:0002934)2.76732595
31positive regulation by symbiont of host defense response (GO:0052509)2.75780871
32modulation by symbiont of host defense response (GO:0052031)2.75780871
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75780871
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75780871
35positive regulation by organism of defense response of other organism involved in symbiotic interact2.75780871
36modulation by symbiont of host immune response (GO:0052553)2.75780871
37phospholipid efflux (GO:0033700)2.74108518
38regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.72995949
39reverse cholesterol transport (GO:0043691)2.72295991
40detection of external biotic stimulus (GO:0098581)2.71833426
41immunoglobulin mediated immune response (GO:0016064)2.70986241
42positive regulation of interferon-alpha production (GO:0032727)2.70606845
43interferon-gamma secretion (GO:0072643)2.70533981
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.70398554
45complement activation, alternative pathway (GO:0006957)2.68153678
46regulation of bile acid biosynthetic process (GO:0070857)2.67786019
47myeloid leukocyte mediated immunity (GO:0002444)2.67644903
48fibrinolysis (GO:0042730)2.66648320
49neutrophil activation (GO:0042119)2.66571985
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66401834
51positive regulation of fatty acid beta-oxidation (GO:0032000)2.65945872
52negative regulation of interleukin-12 production (GO:0032695)2.64076418
53granulocyte activation (GO:0036230)2.63398994
54tryptophan catabolic process (GO:0006569)2.63015963
55indole-containing compound catabolic process (GO:0042436)2.63015963
56indolalkylamine catabolic process (GO:0046218)2.63015963
57tryptophan metabolic process (GO:0006568)2.62912756
58negative regulation of lipid storage (GO:0010888)2.62816721
59cellular response to arsenic-containing substance (GO:0071243)2.61145473
60regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.60870273
61urea metabolic process (GO:0019627)2.60585286
62urea cycle (GO:0000050)2.60585286
63detection of biotic stimulus (GO:0009595)2.59761151
643-UTR-mediated mRNA stabilization (GO:0070935)2.57433505
65cellular glucuronidation (GO:0052695)2.57087495
66aromatic amino acid family catabolic process (GO:0009074)2.56936134
67regulation of protein activation cascade (GO:2000257)2.56689327
68regulation of interferon-alpha production (GO:0032647)2.56682693
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56492445
70L-phenylalanine catabolic process (GO:0006559)2.56492445
71high-density lipoprotein particle remodeling (GO:0034375)2.56390878
72pinocytosis (GO:0006907)2.55791547
73kynurenine metabolic process (GO:0070189)2.55194003
74mannose metabolic process (GO:0006013)2.54835401
75lung vasculature development (GO:0060426)2.54723829
76cellular response to growth hormone stimulus (GO:0071378)2.54511562
77macrophage activation involved in immune response (GO:0002281)2.53194319
78regulation of gamma-delta T cell activation (GO:0046643)2.52148792
79intestinal cholesterol absorption (GO:0030299)2.52090507
80negative regulation of fatty acid transport (GO:2000192)2.51543764
81microglial cell activation (GO:0001774)2.50004412
82regulation of fibrinolysis (GO:0051917)2.49779935
83negative regulation of fibrinolysis (GO:0051918)2.48700913
84response to progesterone (GO:0032570)2.48469071
85acylglycerol homeostasis (GO:0055090)2.48180386
86triglyceride homeostasis (GO:0070328)2.48180386
87apoptotic cell clearance (GO:0043277)2.47685351
88establishment of endothelial barrier (GO:0061028)2.47197468
89low-density lipoprotein particle clearance (GO:0034383)2.47168832
90regulation of complement activation (GO:0030449)2.47010202
91plasma lipoprotein particle clearance (GO:0034381)2.46992525
92trophectodermal cell differentiation (GO:0001829)2.46721658
93phospholipid homeostasis (GO:0055091)2.46629216
94neutrophil chemotaxis (GO:0030593)2.45871871
95cellular response to ethanol (GO:0071361)2.45305839
96detection of bacterium (GO:0016045)2.45198286
97cell adhesion mediated by integrin (GO:0033627)2.45049138
98regulation of triglyceride catabolic process (GO:0010896)2.44254578
99positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.43903632
100negative regulation of toll-like receptor signaling pathway (GO:0034122)2.43758531
101regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.43666517
102iron ion import (GO:0097286)2.43354457
103lipoprotein metabolic process (GO:0042157)2.42874233
104intestinal epithelial cell development (GO:0060576)2.42874026
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.42601826
106L-phenylalanine metabolic process (GO:0006558)2.42601826
107regulation of interleukin-12 biosynthetic process (GO:0045075)2.42129278
108epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41788556
109endothelial cell chemotaxis (GO:0035767)2.41624650
110positive regulation of lipid catabolic process (GO:0050996)2.41522742
111JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.41022035
112wound healing, spreading of epidermal cells (GO:0035313)2.40911328
113negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.40578024
114neutrophil migration (GO:1990266)2.39003331
115response to laminar fluid shear stress (GO:0034616)2.38089593
116transcytosis (GO:0045056)2.37974605
117surfactant homeostasis (GO:0043129)2.36945731
118response to host (GO:0075136)2.36773598
119response to host defenses (GO:0052200)2.36773598
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36773598
121positive regulation of macrophage cytokine production (GO:0060907)2.36188869
122positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35909613
123positive regulation of cholesterol transport (GO:0032376)2.35570100
124positive regulation of sterol transport (GO:0032373)2.35570100
125regulation of macrophage cytokine production (GO:0010935)2.33588546
126regulation of vitamin D biosynthetic process (GO:0060556)2.33529116
127interleukin-1-mediated signaling pathway (GO:0070498)2.32800311
128positive regulation of interleukin-6 production (GO:0032755)2.32375798
129positive regulation of cholesterol efflux (GO:0010875)2.32282960
130acute-phase response (GO:0006953)2.31847921
131chemical homeostasis within a tissue (GO:0048875)2.31294334
132positive regulation of blood coagulation (GO:0030194)2.30596564
133positive regulation of hemostasis (GO:1900048)2.30596564
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30464302
135response to host immune response (GO:0052572)2.30464302
136response to muramyl dipeptide (GO:0032495)2.29386158
137regulation of interferon-beta biosynthetic process (GO:0045357)2.29122247
138production of molecular mediator involved in inflammatory response (GO:0002532)2.28839083
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.28648322
140nitrogen cycle metabolic process (GO:0071941)2.28479353
141bile acid and bile salt transport (GO:0015721)2.28469646
142regulation of heterotypic cell-cell adhesion (GO:0034114)2.28101575
143regulation of interleukin-6 production (GO:0032675)2.28029784
144regulation of cholesterol storage (GO:0010885)2.27964304
145hormone catabolic process (GO:0042447)2.26794608
146mRNA transcription from RNA polymerase II promoter (GO:0042789)2.26234489
147histone H3-K36 demethylation (GO:0070544)2.26044623
148positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.25225858
149regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.25225858
150positive regulation of gamma-delta T cell activation (GO:0046645)2.25220988
151positive regulation of extracellular matrix organization (GO:1903055)2.24387229
152positive regulation of astrocyte differentiation (GO:0048711)2.23708056
153macrophage activation (GO:0042116)2.23308159
154regulation of leukocyte degranulation (GO:0043300)2.23065054
155radial glial cell differentiation (GO:0060019)2.22111799
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21408005
157positive regulation of lipoprotein lipase activity (GO:0051006)2.21308608
158positive regulation of triglyceride lipase activity (GO:0061365)2.21308608
159positive regulation of nitric oxide biosynthetic process (GO:0045429)2.20406253
160alpha-linolenic acid metabolic process (GO:0036109)2.20019217
161regulation of integrin activation (GO:0033623)2.19796219
162negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.19726642
163negative regulation of T-helper cell differentiation (GO:0045623)2.19726642
164positive regulation of coagulation (GO:0050820)2.19582498
165regulation of necroptotic process (GO:0060544)2.18829567
166regulation of T-helper 1 cell differentiation (GO:0045625)2.18651955
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.18540374
168positive regulation of cellular amide metabolic process (GO:0034250)2.18469455
169plasma lipoprotein particle assembly (GO:0034377)2.18452988
170complement activation, classical pathway (GO:0006958)2.18193832
171positive regulation of interferon-beta production (GO:0032728)2.17284562
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.17271183
173cholesterol efflux (GO:0033344)2.16959923
174atrioventricular valve morphogenesis (GO:0003181)2.16847520
175response to protozoan (GO:0001562)2.16777888
176peptide catabolic process (GO:0043171)2.16231344
177regulation of myeloid leukocyte mediated immunity (GO:0002886)2.16033571
178oligosaccharide catabolic process (GO:0009313)2.15828340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.29238694
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.15470430
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53364407
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.40135357
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.24205120
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.24145263
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10900155
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.09549609
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.07988681
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.89731174
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.65759502
12CLOCK_20551151_ChIP-Seq_293T_Human2.51746385
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.41527490
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41314882
15* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38562514
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.31112281
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.30423982
18* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.25202611
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17910662
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17687221
21VDR_21846776_ChIP-Seq_THP-1_Human2.05431037
22* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02326020
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01831363
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01067574
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96169699
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93653871
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90648242
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84330746
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.81609785
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.76992365
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.76575713
32* MYC_22102868_ChIP-Seq_BL_Human1.71924021
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67880841
34* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67405779
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64935760
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63809483
37* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63799415
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62642557
39* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61398591
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.58056166
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52365666
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52072699
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52072699
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50059032
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49292571
46* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46446179
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46059299
48* CJUN_26792858_Chip-Seq_BT549_Human1.41896501
49* SOX2_20726797_ChIP-Seq_SW620_Human1.41442460
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40217734
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40082310
52KDM2B_26808549_Chip-Seq_DND41_Human1.39104007
53ZNF263_19887448_ChIP-Seq_K562_Human1.37663713
54* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37125285
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36131712
56* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33772876
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33417794
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32859873
59* RUNX1_22412390_ChIP-Seq_EML_Mouse1.31251694
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30861886
61* RUNX_20019798_ChIP-Seq_JUKART_Human1.26998500
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.23893278
63* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23426117
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22221293
65* MAF_26560356_Chip-Seq_TH1_Human1.21735642
66GATA1_22025678_ChIP-Seq_K562_Human1.19837411
67* KDM2B_26808549_Chip-Seq_K562_Human1.18691985
68SCL_19346495_ChIP-Seq_HPC-7_Human1.18585558
69* TCF7_22412390_ChIP-Seq_EML_Mouse1.18156898
70* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17424508
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17118745
72* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16491230
73* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16388305
74* VDR_24787735_ChIP-Seq_THP-1_Human1.15939108
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15114383
76GATA4_25053715_ChIP-Seq_YYC3_Human1.14897224
77MYB_26560356_Chip-Seq_TH1_Human1.14314209
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12786636
79* GATA6_25053715_ChIP-Seq_YYC3_Human1.12249828
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11045839
81* ELK3_25401928_ChIP-Seq_HUVEC_Human1.09240888
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08608284
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08464145
84* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07992530
85* PU_27001747_Chip-Seq_BMDM_Mouse1.07647488
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07619861
87* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06523231
88* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06291285
89* SPI1_23547873_ChIP-Seq_NB4_Human1.04954622
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04651862
91* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04589845
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03725756
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02324349
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02132681
95SPI1_23127762_ChIP-Seq_K562_Human1.02120832
96* MYB_26560356_Chip-Seq_TH2_Human1.01788242
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.01326117
98* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01287936
99* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00920995
100* ATF3_27146783_Chip-Seq_COLON_Human1.00386614
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99788072
102RACK7_27058665_Chip-Seq_MCF-7_Human0.99746913
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99333629
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.98693920
105* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97664184
106IRF8_21731497_ChIP-ChIP_J774_Mouse0.96790957
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95552460
108AHR_22903824_ChIP-Seq_MCF-7_Human0.94480512
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94309192
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93607643
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92562633
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92562633
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92562633
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92161072
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.89812319
116* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87889001
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.86564939
118BRD4_25478319_ChIP-Seq_HGPS_Human0.86356546
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85859818
120RXR_22108803_ChIP-Seq_LS180_Human0.85596192
121VDR_24763502_ChIP-Seq_THP-1_Human0.84605172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.05321842
2MP0002139_abnormal_hepatobiliary_system3.03222971
3MP0005085_abnormal_gallbladder_physiolo2.77302464
4MP0003300_gastrointestinal_ulcer2.70500465
5MP0005365_abnormal_bile_salt2.52293514
6MP0003724_increased_susceptibility_to2.50109938
7MP0005360_urolithiasis2.49843349
8MP0003436_decreased_susceptibility_to2.43686957
9MP0005451_abnormal_body_composition2.27134598
10MP0003303_peritoneal_inflammation2.21019454
11MP0010368_abnormal_lymphatic_system2.06726636
12MP0009840_abnormal_foam_cell2.06717405
13MP0003252_abnormal_bile_duct2.01717564
14MP0003705_abnormal_hypodermis_morpholog1.89536779
15MP0005076_abnormal_cell_differentiation1.83808626
16MP0002138_abnormal_hepatobiliary_system1.79826752
17MP0003191_abnormal_cellular_cholesterol1.77313684
18MP0003453_abnormal_keratinocyte_physiol1.70923247
19MP0001666_abnormal_nutrient_absorption1.70132221
20MP0001853_heart_inflammation1.68591105
21MP0003566_abnormal_cell_adhesion1.68326640
22MP0004947_skin_inflammation1.68206633
23MP0008875_abnormal_xenobiotic_pharmacok1.66662731
24MP0005058_abnormal_lysosome_morphology1.64489852
25MP0001533_abnormal_skeleton_physiology1.63014643
26MP0010329_abnormal_lipoprotein_level1.58254613
27MP0003828_pulmonary_edema1.57904649
28MP0010352_gastrointestinal_tract_polyps1.57415197
29MP0002877_abnormal_melanocyte_morpholog1.52753762
30MP0002060_abnormal_skin_morphology1.52429170
31MP0001879_abnormal_lymphatic_vessel1.51025819
32MP0001545_abnormal_hematopoietic_system1.50361973
33MP0005397_hematopoietic_system_phenotyp1.50361973
34MP0010234_abnormal_vibrissa_follicle1.48845252
35MP0005666_abnormal_adipose_tissue1.46772687
36MP0004808_abnormal_hematopoietic_stem1.45620033
37MP0009278_abnormal_bone_marrow1.45024764
38MP0005023_abnormal_wound_healing1.44462328
39MP0001851_eye_inflammation1.42697223
40MP0004185_abnormal_adipocyte_glucose1.42116904
41MP0005083_abnormal_biliary_tract1.41773757
42MP0002933_joint_inflammation1.41319964
43MP0005248_abnormal_Harderian_gland1.39032716
44MP0002796_impaired_skin_barrier1.37717320
45MP0000537_abnormal_urethra_morphology1.37608147
46MP0000609_abnormal_liver_physiology1.34348268
47MP0004019_abnormal_vitamin_homeostasis1.33393525
48MP0000685_abnormal_immune_system1.31142818
49MP0002419_abnormal_innate_immunity1.30321706
50MP0003656_abnormal_erythrocyte_physiolo1.30255637
51MP0003045_fibrosis1.29340782
52MP0005310_abnormal_salivary_gland1.27264291
53MP0001835_abnormal_antigen_presentation1.26448726
54MP0005275_abnormal_skin_tensile1.23836368
55MP0009764_decreased_sensitivity_to1.23682005
56MP0002132_abnormal_respiratory_system1.22841382
57MP0001216_abnormal_epidermal_layer1.22820508
58MP0002098_abnormal_vibrissa_morphology1.22496101
59MP0001873_stomach_inflammation1.20351685
60MP0003172_abnormal_lysosome_physiology1.20100008
61MP0005390_skeleton_phenotype1.19515314
62MP0004510_myositis1.18866554
63MP0002148_abnormal_hypersensitivity_rea1.17138996
64MP0002420_abnormal_adaptive_immunity1.15224865
65MP0001819_abnormal_immune_cell1.14557025
66MP0000383_abnormal_hair_follicle1.14301079
67MP0010155_abnormal_intestine_physiology1.12133979
68MP0000767_abnormal_smooth_muscle1.11527464
69MP0003448_altered_tumor_morphology1.09946651
70MP0006082_CNS_inflammation1.09484261
71MP0002998_abnormal_bone_remodeling1.09005496
72MP0003195_calcinosis1.08612644
73MP0005387_immune_system_phenotype1.07996595
74MP0001790_abnormal_immune_system1.07996595
75MP0005670_abnormal_white_adipose1.07903716
76MP0003941_abnormal_skin_development1.07873074
77MP0009053_abnormal_anal_canal1.07802474
78MP0002166_altered_tumor_susceptibility1.05480181
79MP0005000_abnormal_immune_tolerance1.04015597
80MP0004264_abnormal_extraembryonic_tissu1.02736396
81MP0004883_abnormal_blood_vessel1.02444898
82MP0003279_aneurysm1.01436871
83MP0003075_altered_response_to1.01143988
84MP0010678_abnormal_skin_adnexa1.01078173
85MP0003221_abnormal_cardiomyocyte_apopto1.01035414
86MP0009115_abnormal_fat_cell0.98868790
87MP0005164_abnormal_response_to0.98330154
88MP0009785_altered_susceptibility_to0.97628554
89MP0005375_adipose_tissue_phenotype0.96555954
90MP0001845_abnormal_inflammatory_respons0.95892342
91MP0002332_abnormal_exercise_endurance0.95716069
92MP0002928_abnormal_bile_duct0.95590088
93MP0005025_abnormal_response_to0.95589459
94MP0000858_altered_metastatic_potential0.95578034
95MP0000516_abnormal_urinary_system0.95158986
96MP0005367_renal/urinary_system_phenotyp0.95158986
97MP0001881_abnormal_mammary_gland0.94529209
98MP0002452_abnormal_antigen_presenting0.94267195
99MP0002118_abnormal_lipid_homeostasis0.92019596
100MP0005167_abnormal_blood-brain_barrier0.91738696
101MP0009384_cardiac_valve_regurgitation0.90927865
102MP0000249_abnormal_blood_vessel0.90508049
103MP0002405_respiratory_system_inflammati0.89663999
104MP0004272_abnormal_basement_membrane0.89176463
105MP0008469_abnormal_protein_level0.89097950
106MP0002396_abnormal_hematopoietic_system0.89022418
107MP0008004_abnormal_stomach_pH0.88726336
108MP0001800_abnormal_humoral_immune0.88597419
109MP0005166_decreased_susceptibility_to0.88307748
110MP0001191_abnormal_skin_condition0.88067206
111MP0002168_other_aberrant_phenotype0.87340681
112MP0008961_abnormal_basal_metabolism0.86800294
113MP0002896_abnormal_bone_mineralization0.86144599
114MP0000716_abnormal_immune_system0.86113981
115MP0000627_abnormal_mammary_gland0.85641855
116MP0003868_abnormal_feces_composition0.84955447
117MP0005508_abnormal_skeleton_morphology0.84101664
118MP0000465_gastrointestinal_hemorrhage0.83521921
119MP0008260_abnormal_autophagy0.82028885
120MP0003795_abnormal_bone_structure0.81708678
121MP0005319_abnormal_enzyme/_coenzyme0.81504289
122MP0005220_abnormal_exocrine_pancreas0.81251422
123MP0002723_abnormal_immune_serum0.81113387
124MP0002006_tumorigenesis0.80948857
125MP0003091_abnormal_cell_migration0.79804981
126MP0004782_abnormal_surfactant_physiolog0.79653991
127MP0000343_altered_response_to0.79197409
128MP0002398_abnormal_bone_marrow0.78837896
129MP0005464_abnormal_platelet_physiology0.78475655
130MP0005647_abnormal_sex_gland0.78339921
131MP0002009_preneoplasia0.77362894
132MP0005409_darkened_coat_color0.75648692
133MP0005334_abnormal_fat_pad0.74907579
134MP0008057_abnormal_DNA_replication0.74249614

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)4.22418970
2Xanthomatosis (HP:0000991)3.78054492
3Complement deficiency (HP:0004431)3.60144381
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.41177572
5Eczematoid dermatitis (HP:0000976)3.39875585
6Deep venous thrombosis (HP:0002625)3.35811856
7Systemic lupus erythematosus (HP:0002725)3.35625525
8Intrahepatic cholestasis (HP:0001406)3.31785090
9Prostate neoplasm (HP:0100787)3.27828547
10Abnormality of the fingertips (HP:0001211)3.23448481
11Abnormality of complement system (HP:0005339)3.18826553
12Joint hemorrhage (HP:0005261)3.11307856
13Esophageal varix (HP:0002040)3.11189783
14Abnormality of the common coagulation pathway (HP:0010990)3.06473575
15Right ventricular cardiomyopathy (HP:0011663)3.02422108
16Hypoalphalipoproteinemia (HP:0003233)3.00856174
17Prolonged partial thromboplastin time (HP:0003645)2.99068277
18Glomerulonephritis (HP:0000099)2.95618519
19Increased cerebral lipofuscin (HP:0011813)2.94376020
20Milia (HP:0001056)2.91223079
21Onycholysis (HP:0001806)2.89032462
22Myositis (HP:0100614)2.86559567
23Retrobulbar optic neuritis (HP:0100654)2.85463573
24Optic neuritis (HP:0100653)2.85463573
25Recurrent gram-negative bacterial infections (HP:0005420)2.83286710
26Subacute progressive viral hepatitis (HP:0006572)2.76935541
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.74958817
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.70886823
29Hematochezia (HP:0002573)2.69017839
30Thick nail (HP:0001805)2.67599877
31Interstitial pulmonary disease (HP:0006530)2.61368604
32Pigmentary retinal degeneration (HP:0001146)2.59865283
33Mediastinal lymphadenopathy (HP:0100721)2.58977238
34Atrophic scars (HP:0001075)2.55830975
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52406989
36Sparse lateral eyebrow (HP:0005338)2.52081584
37Hypolipoproteinemia (HP:0010981)2.49386528
38Alopecia of scalp (HP:0002293)2.48532355
39Dysmetric saccades (HP:0000641)2.46185553
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46062367
41Malnutrition (HP:0004395)2.38532338
42Vascular calcification (HP:0004934)2.37840167
43Nephritis (HP:0000123)2.36919965
44Broad face (HP:0000283)2.36518343
45Segmental peripheral demyelination/remyelination (HP:0003481)2.36208682
46Neonatal hypoglycemia (HP:0001998)2.35782109
47Epidermoid cyst (HP:0200040)2.31614995
48Cardiovascular calcification (HP:0011915)2.31540469
49Axonal loss (HP:0003447)2.31304713
50Abnormality of the intrinsic pathway (HP:0010989)2.28977380
51Autoimmune thrombocytopenia (HP:0001973)2.28964317
52Vitreoretinal degeneration (HP:0000655)2.27716412
53Abnormality of proline metabolism (HP:0010907)2.25948835
54Hydroxyprolinuria (HP:0003080)2.25948835
55Plantar hyperkeratosis (HP:0007556)2.25947492
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24006634
57Hyperglycemia (HP:0003074)2.21919252
58Lip pit (HP:0100267)2.21839385
59Hyperlipoproteinemia (HP:0010980)2.20468489
60Tetraparesis (HP:0002273)2.19829239
61Dysostosis multiplex (HP:0000943)2.15610746
62Hypobetalipoproteinemia (HP:0003563)2.15286427
63Vasculitis (HP:0002633)2.15063312
64Spontaneous hematomas (HP:0007420)2.14580432
65Aortic aneurysm (HP:0004942)2.12551512
66Loss of speech (HP:0002371)2.12131471
67Colitis (HP:0002583)2.11256635
68Recurrent bacterial skin infections (HP:0005406)2.10680580
69Hypoglycemic coma (HP:0001325)2.10156442
70Abnormality of the axillary hair (HP:0100134)2.09842058
71Abnormality of secondary sexual hair (HP:0009888)2.09842058
72Fat malabsorption (HP:0002630)2.09798866
73Recurrent skin infections (HP:0001581)2.08672777
74Pustule (HP:0200039)2.08266165
75Viral hepatitis (HP:0006562)2.06596864
76Abnormality of the distal phalanges of the toes (HP:0010182)2.04047146
77Cellulitis (HP:0100658)2.03627427
78Curly hair (HP:0002212)2.03439279
79Distal lower limb muscle weakness (HP:0009053)2.02396468
80Keratoconjunctivitis sicca (HP:0001097)2.01927721
81Elevated erythrocyte sedimentation rate (HP:0003565)2.00373637
82Increased IgE level (HP:0003212)2.00229812
83Neoplasm of the tracheobronchial system (HP:0100552)1.99539921
84Osteolytic defects of the phalanges of the hand (HP:0009771)1.98593580
85Osteolytic defects of the hand bones (HP:0009699)1.98593580
86Depressed nasal tip (HP:0000437)1.96993863
87Autoimmune hemolytic anemia (HP:0001890)1.96908670
88Distal lower limb amyotrophy (HP:0008944)1.96098292
89Gingival bleeding (HP:0000225)1.95647375
90Amyloidosis (HP:0011034)1.94296320
91Abnormality of the prostate (HP:0008775)1.93786039
92Diaphragmatic weakness (HP:0009113)1.93075637
93Increased serum ferritin (HP:0003281)1.92033127
94Abnormality of liposaccharide metabolism (HP:0010968)1.91466299
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.91466299
96Abnormality of glycolipid metabolism (HP:0010969)1.91466299
97Abnormality of the nasal septum (HP:0000419)1.90838610
98Arterial thrombosis (HP:0004420)1.90543225
99Periodontitis (HP:0000704)1.89791028
100Premature rupture of membranes (HP:0001788)1.87853611
101Mitral stenosis (HP:0001718)1.87444394
102Hemorrhage of the eye (HP:0011885)1.87301341
103Pulmonary infiltrates (HP:0002113)1.87220958
104Polycythemia (HP:0001901)1.86878939
105Vacuolated lymphocytes (HP:0001922)1.86402701
106Menorrhagia (HP:0000132)1.86354090
107Bulbar palsy (HP:0001283)1.86336088
108Aneurysm (HP:0002617)1.86234584
109Urethral obstruction (HP:0000796)1.85575066
110Epiphyseal dysplasia (HP:0002656)1.84530247
111Conjugated hyperbilirubinemia (HP:0002908)1.84462501
112Septate vagina (HP:0001153)1.84142144
113Recurrent fungal infections (HP:0002841)1.83810934
114Recurrent viral infections (HP:0004429)1.83660052
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.83542263
116Protuberant abdomen (HP:0001538)1.83451438
117Submucous cleft hard palate (HP:0000176)1.83170062
118Recurrent abscess formation (HP:0002722)1.82625667
119Hemoptysis (HP:0002105)1.82545301
120Hypercholesterolemia (HP:0003124)1.79523515
121Cheilitis (HP:0100825)1.79228582
122Gingivitis (HP:0000230)1.79140308
123Micronodular cirrhosis (HP:0001413)1.78761358
124Osteomyelitis (HP:0002754)1.77454353
125Meningitis (HP:0001287)1.77185587
126Asymmetric septal hypertrophy (HP:0001670)1.76994463
127Abdominal distention (HP:0003270)1.76445217
128Increased connective tissue (HP:0009025)1.74931462
129Peritonitis (HP:0002586)1.74513707
130Cerebral aneurysm (HP:0004944)1.74512014
131Keratoconjunctivitis (HP:0001096)1.73780431
132Fragile nails (HP:0001808)1.71851405
133Acute myeloid leukemia (HP:0004808)1.71495180
134Gangrene (HP:0100758)1.71002580
135Urticaria (HP:0001025)1.70386455
136Progressive visual loss (HP:0000529)1.69387578
137Abnormal tarsal ossification (HP:0008369)1.69334882
138Anal stenosis (HP:0002025)1.69230471
139Polygenic inheritance (HP:0010982)1.68827932
140Increased CSF protein (HP:0002922)1.68433419
141Abnormal foot bone ossification (HP:0010675)1.67960135
142Mitral valve prolapse (HP:0001634)1.67903672
143Hypoplasia of dental enamel (HP:0006297)1.67579491
144Obstructive sleep apnea (HP:0002870)1.67128990
145Hypoplastic ischia (HP:0003175)1.66984376
146Exocrine pancreatic insufficiency (HP:0001738)1.66946208
147Slow saccadic eye movements (HP:0000514)1.65939353
148Abnormality of purine metabolism (HP:0004352)1.65846763
149Mucopolysacchariduria (HP:0008155)1.65826637
150Urinary glycosaminoglycan excretion (HP:0003541)1.65826637
151Vascular tortuosity (HP:0004948)1.64856488
152Spondylolisthesis (HP:0003302)1.63839074
153Arterial tortuosity (HP:0005116)1.63445349
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63414653
155Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63414653
156Alveolar cell carcinoma (HP:0006519)1.63363594
157Rectal prolapse (HP:0002035)1.62929861
158Flat acetabular roof (HP:0003180)1.62601905
159Abnormal platelet function (HP:0011869)1.62598229
160Impaired platelet aggregation (HP:0003540)1.62598229
161Acanthosis nigricans (HP:0000956)1.62274354
162Abnormality of the ischium (HP:0003174)1.61650372
163Abnormality of macrophages (HP:0004311)1.61609455
164Hypoglycemic seizures (HP:0002173)1.61468155
165Hepatocellular carcinoma (HP:0001402)1.61458585
166Insulin-resistant diabetes mellitus (HP:0000831)1.61117218
167Orchitis (HP:0100796)1.60776670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.57942879
2EPHA23.55648855
3FGFR42.89742434
4TGFBR22.79080028
5MAPK152.78446830
6EPHA32.74221649
7MAP3K32.74079670
8EPHB12.56574467
9AKT32.44352791
10MAP3K142.36538704
11PRPF4B2.15309609
12LATS12.14638088
13TNK22.00602437
14RIPK11.99252298
15IRAK31.92985675
16SIK11.92853447
17TBK11.89955054
18RIPK41.86571759
19MAP3K101.66987105
20MAP2K21.66083200
21TYK21.63469303
22CHUK1.57946818
23FGFR31.56562635
24FRK1.51727162
25TAOK31.50232649
26IKBKE1.45495804
27PIM21.44366407
28INSRR1.42448745
29IKBKB1.41072375
30RPS6KA41.39743639
31EEF2K1.37122077
32PTK61.36598941
33BMPR21.36441970
34NLK1.33593133
35BRD41.29355014
36JAK11.29142597
37CDK121.27420514
38TRIB31.27070921
39NEK91.26294860
40BRSK21.25980300
41MAP3K131.24946726
42MAP3K21.22237030
43STK101.19935317
44MARK21.15843404
45MST41.15683569
46FER1.13975563
47MST1R1.10657513
48CDK61.10648569
49IRAK11.09845781
50TAOK21.06761609
51CAMK1D1.04953187
52STK241.04582516
53CSK1.04265143
54MAP4K11.03457075
55SIK31.03198853
56GSK3A1.01814602
57ICK0.99553652
58DMPK0.98299602
59HIPK20.97557010
60JAK30.97116807
61NUAK10.95809071
62JAK20.94376078
63SMG10.93662095
64MATK0.93107328
65PTK20.92116889
66EPHB20.91668282
67MAP2K30.90900266
68MAP3K10.90646547
69YES10.90134699
70IRAK40.89504060
71ERBB20.88871749
72KDR0.88533922
73CDC42BPA0.85392742
74LMTK20.84718524
75PDGFRB0.81781444
76MAPK70.79245527
77ITK0.78376153
78ZAP700.77681679
79PRKG20.77290917
80LATS20.77243122
81TIE10.77123276
82SGK30.74314851
83CDK90.73901549
84PIK3CG0.73854379
85TGFBR10.71329318
86FGFR20.71248973
87FGR0.68143345
88PRKD20.67352197
89MAPKAPK20.65864266
90PIM10.65344739
91MAPK40.64791364
92CSF1R0.64436790
93CAMK1G0.62818966
94STK38L0.62455671
95PDPK10.62272974
96DYRK1B0.61506631
97MKNK20.61336815
98TAOK10.59113604
99STK30.58669541
100PDGFRA0.57936698
101BMX0.57918302
102MAP3K70.57731970
103HCK0.57573496
104TEC0.56742449
105ERBB40.56634730
106MTOR0.54817991
107MAP3K110.54281150
108MOS0.53707915
109NEK60.49006336
110PKN20.48830995
111PAK40.48535353
112LRRK20.48451596
113PIK3CA0.48010470
114MET0.46784916
115SGK20.46537166
116EGFR0.46501157
117PRKAA20.46362375
118GRK70.45956261
119MELK0.45818934
120PAK20.45008007
121PDK20.44225752
122TTN0.43220380
123MAPK120.42313283
124RPS6KA60.42205904
125TRPM70.41424152
126BLK0.40616001
127RPS6KL10.40475067
128ABL10.40362628
129IGF1R0.40030329
130ERBB30.38004444
131RPS6KA10.37104830
132CDK30.36111237
133IRAK20.35741923
134RPS6KC10.34839272

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.91516102
2Complement and coagulation cascades_Homo sapiens_hsa046102.61715507
3Nitrogen metabolism_Homo sapiens_hsa009102.53064545
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.45708236
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43540272
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.33360128
7Caffeine metabolism_Homo sapiens_hsa002322.07215191
8Leishmaniasis_Homo sapiens_hsa051401.76219818
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74426167
10Arginine biosynthesis_Homo sapiens_hsa002201.67932905
11Osteoclast differentiation_Homo sapiens_hsa043801.60228714
12Tryptophan metabolism_Homo sapiens_hsa003801.59064814
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48557429
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.40644388
15Histidine metabolism_Homo sapiens_hsa003401.38045127
16Chemical carcinogenesis_Homo sapiens_hsa052041.37572934
17TNF signaling pathway_Homo sapiens_hsa046681.34587359
18Malaria_Homo sapiens_hsa051441.34273732
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32868661
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28907783
21Renal cell carcinoma_Homo sapiens_hsa052111.27154734
22Fatty acid degradation_Homo sapiens_hsa000711.26869152
23Toxoplasmosis_Homo sapiens_hsa051451.25844352
24Starch and sucrose metabolism_Homo sapiens_hsa005001.24756884
25PPAR signaling pathway_Homo sapiens_hsa033201.23641383
26Fat digestion and absorption_Homo sapiens_hsa049751.19909848
27Legionellosis_Homo sapiens_hsa051341.19262223
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19239391
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17907092
30Pertussis_Homo sapiens_hsa051331.13509673
31Retinol metabolism_Homo sapiens_hsa008301.12879450
32Insulin resistance_Homo sapiens_hsa049311.11858361
33ECM-receptor interaction_Homo sapiens_hsa045121.08423707
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08372549
35Adherens junction_Homo sapiens_hsa045201.08274188
36Herpes simplex infection_Homo sapiens_hsa051681.07257895
37Sulfur metabolism_Homo sapiens_hsa009201.06937656
38Non-small cell lung cancer_Homo sapiens_hsa052231.06813869
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04250142
40African trypanosomiasis_Homo sapiens_hsa051431.03807346
41ABC transporters_Homo sapiens_hsa020101.03664525
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03021404
43Phenylalanine metabolism_Homo sapiens_hsa003601.01996640
44Fatty acid biosynthesis_Homo sapiens_hsa000611.01305366
45Thyroid cancer_Homo sapiens_hsa052160.99994232
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98076849
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97860102
48Vitamin digestion and absorption_Homo sapiens_hsa049770.97048042
49Endometrial cancer_Homo sapiens_hsa052130.96546228
50Selenocompound metabolism_Homo sapiens_hsa004500.96154491
51Amoebiasis_Homo sapiens_hsa051460.93508198
52Bile secretion_Homo sapiens_hsa049760.92817393
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.92578904
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.92277362
55Rheumatoid arthritis_Homo sapiens_hsa053230.90127951
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.89644189
57VEGF signaling pathway_Homo sapiens_hsa043700.88755092
58ErbB signaling pathway_Homo sapiens_hsa040120.88261480
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88204186
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87802537
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.86746636
62Hepatitis C_Homo sapiens_hsa051600.83780601
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.82565640
64Bladder cancer_Homo sapiens_hsa052190.82521079
65Small cell lung cancer_Homo sapiens_hsa052220.82307488
66Insulin signaling pathway_Homo sapiens_hsa049100.82283034
67Sphingolipid metabolism_Homo sapiens_hsa006000.81706777
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81702838
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.81386835
70Type II diabetes mellitus_Homo sapiens_hsa049300.81343510
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80945324
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80942995
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.80543201
74Chemokine signaling pathway_Homo sapiens_hsa040620.79234556
75Autoimmune thyroid disease_Homo sapiens_hsa053200.78976914
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78918197
77beta-Alanine metabolism_Homo sapiens_hsa004100.78865750
78T cell receptor signaling pathway_Homo sapiens_hsa046600.77576205
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77391377
80Apoptosis_Homo sapiens_hsa042100.77078833
81Lysine degradation_Homo sapiens_hsa003100.76876127
82Influenza A_Homo sapiens_hsa051640.76816302
83Asthma_Homo sapiens_hsa053100.76756143
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.76034702
85Proteoglycans in cancer_Homo sapiens_hsa052050.75902940
86Renin-angiotensin system_Homo sapiens_hsa046140.75755872
87Allograft rejection_Homo sapiens_hsa053300.74545215
88HIF-1 signaling pathway_Homo sapiens_hsa040660.74463846
89Chronic myeloid leukemia_Homo sapiens_hsa052200.73484526
90Dorso-ventral axis formation_Homo sapiens_hsa043200.73414985
91Prion diseases_Homo sapiens_hsa050200.72673252
92Acute myeloid leukemia_Homo sapiens_hsa052210.72360586
93B cell receptor signaling pathway_Homo sapiens_hsa046620.71643944
94Tuberculosis_Homo sapiens_hsa051520.70253465
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69281700
96Focal adhesion_Homo sapiens_hsa045100.68794390
97Estrogen signaling pathway_Homo sapiens_hsa049150.68415840
98Notch signaling pathway_Homo sapiens_hsa043300.68010899
99Folate biosynthesis_Homo sapiens_hsa007900.67909514
100Measles_Homo sapiens_hsa051620.67195173
101GnRH signaling pathway_Homo sapiens_hsa049120.66413894
102Peroxisome_Homo sapiens_hsa041460.66201996
103Hepatitis B_Homo sapiens_hsa051610.65723285
104Prolactin signaling pathway_Homo sapiens_hsa049170.65015528
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64757193
106Lysosome_Homo sapiens_hsa041420.63091601
107Shigellosis_Homo sapiens_hsa051310.63043994
108Viral myocarditis_Homo sapiens_hsa054160.62371844
109mTOR signaling pathway_Homo sapiens_hsa041500.62062315
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60207095
111Antigen processing and presentation_Homo sapiens_hsa046120.60186745
112Platelet activation_Homo sapiens_hsa046110.60126734
113Protein digestion and absorption_Homo sapiens_hsa049740.59925254
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59296148
115Colorectal cancer_Homo sapiens_hsa052100.59147590
116Pancreatic secretion_Homo sapiens_hsa049720.58961043
117Type I diabetes mellitus_Homo sapiens_hsa049400.57897268
118Hematopoietic cell lineage_Homo sapiens_hsa046400.57697706
119Other glycan degradation_Homo sapiens_hsa005110.57475229
120MAPK signaling pathway_Homo sapiens_hsa040100.57110413
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56934465
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.56690214
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56284941
124Fructose and mannose metabolism_Homo sapiens_hsa000510.56237975
125Viral carcinogenesis_Homo sapiens_hsa052030.56097024
126Fatty acid metabolism_Homo sapiens_hsa012120.55791018
127HTLV-I infection_Homo sapiens_hsa051660.55517620
128Choline metabolism in cancer_Homo sapiens_hsa052310.54094425
129Circadian rhythm_Homo sapiens_hsa047100.53708305
130Prostate cancer_Homo sapiens_hsa052150.53243076
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53212158
132Pancreatic cancer_Homo sapiens_hsa052120.52917050
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51850582
134AMPK signaling pathway_Homo sapiens_hsa041520.51661431
135Salmonella infection_Homo sapiens_hsa051320.51403464
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51320837
137Tyrosine metabolism_Homo sapiens_hsa003500.50700364
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50203350
139Graft-versus-host disease_Homo sapiens_hsa053320.49544374
140FoxO signaling pathway_Homo sapiens_hsa040680.49501729
141Mineral absorption_Homo sapiens_hsa049780.45785794
142MicroRNAs in cancer_Homo sapiens_hsa052060.44404833
143Galactose metabolism_Homo sapiens_hsa000520.44189221
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43532073
145TGF-beta signaling pathway_Homo sapiens_hsa043500.42974326

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