TRIB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)5.60767486
2ionotropic glutamate receptor signaling pathway (GO:0035235)4.82735065
3cerebral cortex radially oriented cell migration (GO:0021799)4.09392330
4establishment of mitochondrion localization (GO:0051654)4.04128497
5mechanosensory behavior (GO:0007638)4.03750882
6cell migration in hindbrain (GO:0021535)3.93890231
7innervation (GO:0060384)3.87126987
8pyrimidine nucleobase catabolic process (GO:0006208)3.76067579
9glutamate receptor signaling pathway (GO:0007215)3.55171751
10protein localization to synapse (GO:0035418)3.53961001
11neuron cell-cell adhesion (GO:0007158)3.51862995
12layer formation in cerebral cortex (GO:0021819)3.48586771
13startle response (GO:0001964)3.46691682
14synaptic transmission, glutamatergic (GO:0035249)3.36948462
15nonmotile primary cilium assembly (GO:0035058)3.32725970
16neuronal stem cell maintenance (GO:0097150)3.30892875
17calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.28423835
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26549776
19forebrain neuron differentiation (GO:0021879)3.20762179
20cell communication by electrical coupling (GO:0010644)3.17380030
21establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11564438
22mitochondrion transport along microtubule (GO:0047497)3.11564438
23central nervous system neuron axonogenesis (GO:0021955)3.10521087
24atrial cardiac muscle cell action potential (GO:0086014)3.09537606
25Notch signaling involved in heart development (GO:0061314)3.07222479
26dendrite morphogenesis (GO:0048813)3.05819123
27retinal ganglion cell axon guidance (GO:0031290)3.05529010
28activated T cell proliferation (GO:0050798)3.04158797
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.03727002
30limb bud formation (GO:0060174)3.00945817
31synaptic vesicle exocytosis (GO:0016079)3.00217647
32negative regulation of dendrite development (GO:2000171)2.99028067
33camera-type eye morphogenesis (GO:0048593)2.98928486
34sodium ion export (GO:0071436)2.96839451
35negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93708275
36negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.93172934
37vocalization behavior (GO:0071625)2.92756411
38synaptic vesicle docking involved in exocytosis (GO:0016081)2.92273089
39transmission of nerve impulse (GO:0019226)2.91827078
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89607185
41response to pheromone (GO:0019236)2.87902756
42axonogenesis (GO:0007409)2.87601604
43membrane assembly (GO:0071709)2.86664236
44synapse organization (GO:0050808)2.86434627
45cerebral cortex cell migration (GO:0021795)2.85771203
46postsynaptic membrane organization (GO:0001941)2.85217740
47heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.85151344
48axon extension involved in axon guidance (GO:0048846)2.84114490
49neuron projection extension involved in neuron projection guidance (GO:1902284)2.84114490
50synaptic vesicle maturation (GO:0016188)2.82989822
51neuronal action potential propagation (GO:0019227)2.80945603
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79675710
53sympathetic nervous system development (GO:0048485)2.79161378
54positive regulation of neuroblast proliferation (GO:0002052)2.78918328
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78037655
56axon extension (GO:0048675)2.77209668
57neuron recognition (GO:0008038)2.75717141
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75632218
59apical protein localization (GO:0045176)2.75178676
60axon regeneration (GO:0031103)2.74633002
61regulation of NFAT protein import into nucleus (GO:0051532)2.74031893
62regulation of respiratory system process (GO:0044065)2.73280326
63regulation of synapse structural plasticity (GO:0051823)2.73279522
64regulation of axon guidance (GO:1902667)2.70833555
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70385760
66negative regulation of sodium ion transport (GO:0010766)2.70209625
67head development (GO:0060322)2.69621421
68neuronal ion channel clustering (GO:0045161)2.69409833
69hippocampus development (GO:0021766)2.68596011
70regulation of synaptic vesicle exocytosis (GO:2000300)2.68071775
71dendrite development (GO:0016358)2.67518212
72negative regulation of dendrite morphogenesis (GO:0050774)2.67270891
73central nervous system projection neuron axonogenesis (GO:0021952)2.65512881
74regulation of development, heterochronic (GO:0040034)2.65424813
75regulation of axon extension involved in axon guidance (GO:0048841)2.64907634
76neuron-neuron synaptic transmission (GO:0007270)2.64794196
77lateral sprouting from an epithelium (GO:0060601)2.64022094
78presynaptic membrane assembly (GO:0097105)2.63084966
79retinal rod cell development (GO:0046548)2.62901024
80suckling behavior (GO:0001967)2.61222901
81spinal cord development (GO:0021510)2.61085557
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60972580
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.60418780
84glomerulus development (GO:0032835)2.60341201
85positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.59624936
86axonal fasciculation (GO:0007413)2.59244115
87neuron projection regeneration (GO:0031102)2.59169422
88ganglion development (GO:0061548)2.58981969
89regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57605027
90regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57478947
91negative regulation of axon guidance (GO:1902668)2.56519852
92establishment of nucleus localization (GO:0040023)2.55926596
93embryonic retina morphogenesis in camera-type eye (GO:0060059)2.55012359
94outer ear morphogenesis (GO:0042473)2.54849708
95negative regulation of axonogenesis (GO:0050771)2.54269115
96oligodendrocyte differentiation (GO:0048709)2.53623125
97regulation of respiratory gaseous exchange (GO:0043576)2.53322505
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.52666957
99neurotransmitter-gated ion channel clustering (GO:0072578)2.52516437
100dendritic spine morphogenesis (GO:0060997)2.52367024
101neuron projection morphogenesis (GO:0048812)2.51936161
102locomotory exploration behavior (GO:0035641)2.51193744
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.50405214
104heart valve formation (GO:0003188)2.50133822
105olfactory bulb development (GO:0021772)2.49374837
106negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.49143241
107clathrin coat assembly (GO:0048268)2.48729532
108ephrin receptor signaling pathway (GO:0048013)2.48164732
109negative regulation of neurotransmitter transport (GO:0051589)2.48104180
110regulation of glutamate receptor signaling pathway (GO:1900449)2.47907811
111long-chain fatty acid biosynthetic process (GO:0042759)2.47407744
112tongue development (GO:0043586)2.46381767
113regulation of relaxation of muscle (GO:1901077)2.45767594
114positive regulation of axon extension (GO:0045773)2.45323788
115potassium ion export (GO:0071435)2.45035710
116nucleobase catabolic process (GO:0046113)2.44303406
117positive regulation of synapse assembly (GO:0051965)2.43962323
118negative regulation of axon extension involved in axon guidance (GO:0048843)2.43462494
119negative regulation of microtubule polymerization (GO:0031115)2.42409612
120membrane repolarization (GO:0086009)2.41183352
121cellular potassium ion homeostasis (GO:0030007)2.41001307
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.39615030
123endocardial cushion morphogenesis (GO:0003203)2.38492865
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.38234852
125regulation of glycogen (starch) synthase activity (GO:2000465)2.37641393
126auditory behavior (GO:0031223)2.36861376
127cranial nerve structural organization (GO:0021604)2.35823163
128retinal cone cell development (GO:0046549)2.33895502
129regulation of membrane repolarization (GO:0060306)2.32823004
130positive T cell selection (GO:0043368)2.32345308
131facial nerve structural organization (GO:0021612)2.31326653
132negative regulation of axon extension (GO:0030517)2.28495528
133regulation of axon extension (GO:0030516)2.27020028
134cerebellar Purkinje cell differentiation (GO:0021702)2.26959805
135cellular response to prostaglandin stimulus (GO:0071379)2.26424519
136lymph vessel development (GO:0001945)2.25577987
137peripheral nervous system neuron development (GO:0048935)2.25406276
138endothelial cell differentiation (GO:0045446)2.24833769
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.24763515
140regulation of synaptic vesicle transport (GO:1902803)2.24650133
141synapse assembly (GO:0007416)2.21582703
142regulation of rhodopsin mediated signaling pathway (GO:0022400)2.21560020
143cardiac myofibril assembly (GO:0055003)2.21218398
144glutamate secretion (GO:0014047)2.21120781
145photoreceptor cell development (GO:0042461)2.20406049
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.20075640
147neuron projection extension (GO:1990138)2.18664255
148metanephric mesenchyme development (GO:0072075)2.18621727
149neuron migration (GO:0001764)2.18502247
150potassium ion import (GO:0010107)2.17119075
151generation of neurons (GO:0048699)2.17056317
152membrane depolarization during action potential (GO:0086010)2.17038245
153negative regulation of calcium ion transport into cytosol (GO:0010523)2.16494406
154neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.16399261
155exploration behavior (GO:0035640)2.15666025
156response to auditory stimulus (GO:0010996)2.14964942
157myoblast fusion (GO:0007520)2.13815513
158coronary vasculature morphogenesis (GO:0060977)2.13712381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64675233
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.26202191
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99663363
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89115589
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.86303640
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.80701829
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77808857
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77808857
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67328330
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66052519
11GBX2_23144817_ChIP-Seq_PC3_Human2.64927050
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64524758
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59168262
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.57784219
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57049717
16AR_21572438_ChIP-Seq_LNCaP_Human2.55653000
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.33377461
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31321071
19* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24015939
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14807850
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14699104
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.12626220
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.09399894
24* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07832635
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06019181
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98695058
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96724540
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.95148654
29* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93497786
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92288573
31ZNF274_21170338_ChIP-Seq_K562_Hela1.83225897
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.82304544
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80742352
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80457237
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.78606785
36TAF15_26573619_Chip-Seq_HEK293_Human1.74921567
37* RING1B_27294783_Chip-Seq_ESCs_Mouse1.69953484
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63913608
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62012725
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.59934440
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.54047376
42REST_21632747_ChIP-Seq_MESCs_Mouse1.51546350
43DROSHA_22980978_ChIP-Seq_HELA_Human1.50673714
44* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49027895
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45623098
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45398394
47* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41993281
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41028579
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40304461
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40126719
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38437286
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38149822
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37909218
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37712862
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.35537967
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.34169331
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32719418
58* P300_19829295_ChIP-Seq_ESCs_Human1.32466492
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30429249
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28195210
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27519257
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.25631632
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.24571035
64SOX9_26525672_Chip-Seq_HEART_Mouse1.22489897
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22154044
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.22094662
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.21303431
68SMAD4_21799915_ChIP-Seq_A2780_Human1.20559872
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19846083
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19513883
71* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18724461
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18590304
73TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18583692
74* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17655529
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17425068
76* ARNT_22903824_ChIP-Seq_MCF-7_Human1.17407274
77* KDM2B_26808549_Chip-Seq_K562_Human1.17228756
78* RUNX_20019798_ChIP-Seq_JUKART_Human1.16824077
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16707911
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16666511
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16304035
82* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16225320
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15984506
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14747930
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.14385804
86FUS_26573619_Chip-Seq_HEK293_Human1.12909164
87AR_19668381_ChIP-Seq_PC3_Human1.12891856
88BCAT_22108803_ChIP-Seq_LS180_Human1.12809979
89* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12527130
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12278773
91AHR_22903824_ChIP-Seq_MCF-7_Human1.11938134
92KDM2B_26808549_Chip-Seq_REH_Human1.11573901
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11572127
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11572127
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11247962
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10420404
97IGF1R_20145208_ChIP-Seq_DFB_Human1.09257587
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07521874
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06861156
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06439997
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06234863
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06139124
103* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06127051
104* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05607359
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05490546
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.04628064
107SMAD3_21741376_ChIP-Seq_ESCs_Human1.04526983
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04340136
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03736878
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03282787
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02879735
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02546762
113* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01894870
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.01635678
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01096399
116* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01065996
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00660366
118AR_25329375_ChIP-Seq_VCAP_Human1.00515932
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00031885
120* EP300_21415370_ChIP-Seq_HL-1_Mouse0.99191773
121* KDM2B_26808549_Chip-Seq_DND41_Human0.98245152
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97520383
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97173698
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96272189
125WDR5_24793694_ChIP-Seq_LNCAP_Human0.95579078
126* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92516335
127STAT3_23295773_ChIP-Seq_U87_Human0.91155327
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.90761310
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90281507
130TP63_19390658_ChIP-ChIP_HaCaT_Human0.89053202
131* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88811046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation3.23898800
2MP0002822_catalepsy2.98344951
3MP0004858_abnormal_nervous_system2.75774474
4MP0004859_abnormal_synaptic_plasticity2.57617633
5MP0000778_abnormal_nervous_system2.47674629
6MP0006276_abnormal_autonomic_nervous2.35757509
7MP0005423_abnormal_somatic_nervous2.34585524
8MP0006072_abnormal_retinal_apoptosis2.29303417
9MP0003136_yellow_coat_color2.27670215
10MP0003122_maternal_imprinting2.27575074
11MP0005551_abnormal_eye_electrophysiolog2.24591200
12MP0002735_abnormal_chemical_nociception2.11200100
13MP0003880_abnormal_central_pattern2.09914850
14MP0001984_abnormal_olfaction2.06350796
15MP0003635_abnormal_synaptic_transmissio2.04545438
16MP0001968_abnormal_touch/_nociception2.04242837
17MP0002653_abnormal_ependyma_morphology1.96574212
18MP0002184_abnormal_innervation1.93501706
19MP0000537_abnormal_urethra_morphology1.90081801
20MP0000569_abnormal_digit_pigmentation1.89878639
21MP0004270_analgesia1.88106560
22MP0008789_abnormal_olfactory_epithelium1.83882221
23MP0005253_abnormal_eye_physiology1.72675659
24MP0000751_myopathy1.72119322
25MP0002063_abnormal_learning/memory/cond1.70268188
26MP0003942_abnormal_urinary_system1.67431430
27MP0004084_abnormal_cardiac_muscle1.66473300
28MP0002734_abnormal_mechanical_nocicepti1.65184522
29MP0005394_taste/olfaction_phenotype1.61694280
30MP0005499_abnormal_olfactory_system1.61694280
31MP0004215_abnormal_myocardial_fiber1.58563819
32MP0003279_aneurysm1.56327614
33MP0010030_abnormal_orbit_morphology1.55852662
34MP0000049_abnormal_middle_ear1.50207176
35MP0000534_abnormal_ureter_morphology1.48891309
36MP0003787_abnormal_imprinting1.47609304
37MP0002067_abnormal_sensory_capabilities1.43874557
38MP0002127_abnormal_cardiovascular_syste1.42737025
39MP0002751_abnormal_autonomic_nervous1.40741038
40MP0001986_abnormal_taste_sensitivity1.40533777
41MP0001502_abnormal_circadian_rhythm1.38176579
42MP0002882_abnormal_neuron_morphology1.37796834
43MP0008569_lethality_at_weaning1.37745624
44MP0002752_abnormal_somatic_nervous1.35514475
45MP0000631_abnormal_neuroendocrine_gland1.35075660
46MP0001486_abnormal_startle_reflex1.33841314
47MP0002009_preneoplasia1.33805003
48MP0001879_abnormal_lymphatic_vessel1.33610867
49MP0003329_amyloid_beta_deposits1.33175165
50MP0009250_abnormal_appendicular_skeleto1.32587756
51MP0009745_abnormal_behavioral_response1.31777281
52MP0004811_abnormal_neuron_physiology1.31130077
53MP0005623_abnormal_meninges_morphology1.30825627
54MP0002638_abnormal_pupillary_reflex1.29767232
55MP0000955_abnormal_spinal_cord1.29220124
56MP0002736_abnormal_nociception_after1.28483960
57MP0002557_abnormal_social/conspecific_i1.28380072
58MP0002233_abnormal_nose_morphology1.28053952
59MP0003121_genomic_imprinting1.27749878
60MP0001188_hyperpigmentation1.25455179
61MP0000566_synostosis1.25025689
62MP0005195_abnormal_posterior_eye1.25023331
63MP0005257_abnormal_intraocular_pressure1.24501462
64MP0003861_abnormal_nervous_system1.23225919
65MP0002572_abnormal_emotion/affect_behav1.21528013
66MP0002102_abnormal_ear_morphology1.21121508
67MP0003137_abnormal_impulse_conducting1.19427179
68MP0002152_abnormal_brain_morphology1.17786657
69MP0002733_abnormal_thermal_nociception1.17538039
70MP0003567_abnormal_fetal_cardiomyocyte1.17510096
71MP0008961_abnormal_basal_metabolism1.17115323
72MP0003385_abnormal_body_wall1.16714631
73MP0004085_abnormal_heartbeat1.16227486
74MP0002064_seizures1.15789779
75MP0001970_abnormal_pain_threshold1.14413374
76MP0002282_abnormal_trachea_morphology1.13911139
77MP0001177_atelectasis1.12834193
78MP0005646_abnormal_pituitary_gland1.12309770
79MP0004272_abnormal_basement_membrane1.11465203
80MP0005187_abnormal_penis_morphology1.10974827
81MP0001270_distended_abdomen1.10752635
82MP0004142_abnormal_muscle_tone1.09632447
83MP0003763_abnormal_thymus_physiology1.09175309
84MP0005248_abnormal_Harderian_gland1.09124068
85MP0008775_abnormal_heart_ventricle1.06204873
86MP0002697_abnormal_eye_size1.05399871
87MP0003937_abnormal_limbs/digits/tail_de1.04983378
88MP0004484_altered_response_of1.03274409
89MP0002272_abnormal_nervous_system1.02181725
90MP0003935_abnormal_craniofacial_develop1.02116325
91MP0002909_abnormal_adrenal_gland1.01432346
92MP0009384_cardiac_valve_regurgitation0.98247601
93MP0003938_abnormal_ear_development0.98202666
94MP0004885_abnormal_endolymph0.97894327
95MP0005503_abnormal_tendon_morphology0.97338708
96MP0002066_abnormal_motor_capabilities/c0.96581296
97MP0002089_abnormal_postnatal_growth/wei0.96334377
98MP0002116_abnormal_craniofacial_bone0.95922371
99MP0002972_abnormal_cardiac_muscle0.95425833
100MP0000428_abnormal_craniofacial_morphol0.95011294
101MP0001958_emphysema0.94469196
102MP0003878_abnormal_ear_physiology0.94270646
103MP0005377_hearing/vestibular/ear_phenot0.94270646
104MP0005386_behavior/neurological_phenoty0.94259772
105MP0004924_abnormal_behavior0.94259772
106MP0002095_abnormal_skin_pigmentation0.93717809
107MP0001293_anophthalmia0.93326380
108MP0001286_abnormal_eye_development0.92437867
109MP0003011_delayed_dark_adaptation0.91200274
110MP0005391_vision/eye_phenotype0.90595769
111MP0004233_abnormal_muscle_weight0.89461828
112MP0003755_abnormal_palate_morphology0.88034263
113MP0001529_abnormal_vocalization0.86434394
114MP0004742_abnormal_vestibular_system0.86157342
115MP0002081_perinatal_lethality0.86001337
116MP0001943_abnormal_respiration0.85059602
117MP0001963_abnormal_hearing_physiology0.84519176
118MP0003119_abnormal_digestive_system0.83507465
119MP0002932_abnormal_joint_morphology0.83038725
120MP0009780_abnormal_chondrocyte_physiolo0.82338753
121MP0005620_abnormal_muscle_contractility0.81386020
122MP0001299_abnormal_eye_distance/0.81208452
123MP0002938_white_spotting0.80044691
124MP0003634_abnormal_glial_cell0.80018989
125MP0004036_abnormal_muscle_relaxation0.79728741
126MP0009379_abnormal_foot_pigmentation0.79532796
127MP0000026_abnormal_inner_ear0.79181406
128MP0002249_abnormal_larynx_morphology0.77022512
129MP0002092_abnormal_eye_morphology0.75765945
130MP0002177_abnormal_outer_ear0.75189470
131MP0002082_postnatal_lethality0.74623271
132MP0010770_preweaning_lethality0.74623271

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.77034481
2Cortical dysplasia (HP:0002539)3.36966979
3Bony spicule pigmentary retinopathy (HP:0007737)3.17777764
4Abnormal rod and cone electroretinograms (HP:0008323)3.02291158
5Hemiplegia (HP:0002301)2.96524395
6Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92591880
7Neonatal short-limb short stature (HP:0008921)2.80886873
8Central scotoma (HP:0000603)2.77400605
9Turricephaly (HP:0000262)2.72877973
10Scotoma (HP:0000575)2.71775744
11Ulnar claw (HP:0001178)2.70343408
12Hemiparesis (HP:0001269)2.69586448
13Morphological abnormality of the middle ear (HP:0008609)2.68021843
14Pendular nystagmus (HP:0012043)2.63468877
15Vertebral arch anomaly (HP:0008438)2.61225655
16Split foot (HP:0001839)2.54062940
17Gait imbalance (HP:0002141)2.52048163
18Chorioretinal atrophy (HP:0000533)2.44432601
19Insidious onset (HP:0003587)2.41670172
20Termporal pattern (HP:0011008)2.41670172
21Blue irides (HP:0000635)2.37971046
22Hypoplasia of the brainstem (HP:0002365)2.34782013
23Aplasia/Hypoplasia of the brainstem (HP:0007362)2.34782013
24Severe visual impairment (HP:0001141)2.33158702
25Trigonocephaly (HP:0000243)2.31912337
26Keratoconus (HP:0000563)2.30869236
27Increased corneal curvature (HP:0100692)2.30869236
28Pheochromocytoma (HP:0002666)2.26644112
29Spinal canal stenosis (HP:0003416)2.24446529
30Shawl scrotum (HP:0000049)2.23500887
31Intestinal atresia (HP:0011100)2.17466819
32Hypoventilation (HP:0002791)2.16697038
33Mild short stature (HP:0003502)2.16155478
34Focal seizures (HP:0007359)2.15718705
35Polyphagia (HP:0002591)2.14655024
36Limb dystonia (HP:0002451)2.13580781
37Abnormality of the lower motor neuron (HP:0002366)2.12083966
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.11261349
39Midline defect of the nose (HP:0004122)2.10130948
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09690430
41Short 4th metacarpal (HP:0010044)2.09690430
42Narrow nasal bridge (HP:0000446)2.09297882
43Myokymia (HP:0002411)2.08002383
44Urinary urgency (HP:0000012)2.07698133
45Abnormality of the ischium (HP:0003174)2.06185188
46Abnormal hair whorl (HP:0010721)2.06069940
47Epileptic encephalopathy (HP:0200134)2.04743701
48Vaginal atresia (HP:0000148)2.04251991
49Congenital primary aphakia (HP:0007707)2.03466633
50Macroorchidism (HP:0000053)2.03271386
51Hyperventilation (HP:0002883)2.03170633
52Renal hypoplasia (HP:0000089)2.02571846
53Abnormality of the diencephalon (HP:0010662)2.02430993
54Peripheral hypomyelination (HP:0007182)2.02231835
55Megalencephaly (HP:0001355)2.00480996
56Amyotrophic lateral sclerosis (HP:0007354)2.00302766
57Genital tract atresia (HP:0001827)2.00000603
58Focal motor seizures (HP:0011153)1.99617352
59High anterior hairline (HP:0009890)1.98859868
60Humeroradial synostosis (HP:0003041)1.96200340
61Synostosis involving the elbow (HP:0003938)1.96200340
62Progressive cerebellar ataxia (HP:0002073)1.96160843
63Specific learning disability (HP:0001328)1.96064535
64Vitreoretinal degeneration (HP:0000655)1.96042428
65Aqueductal stenosis (HP:0002410)1.95807443
66Neuroendocrine neoplasm (HP:0100634)1.95799658
67Absent speech (HP:0001344)1.94762572
68Shallow orbits (HP:0000586)1.94694987
69Nephrogenic diabetes insipidus (HP:0009806)1.94246574
70Renal duplication (HP:0000075)1.92909379
71Broad foot (HP:0001769)1.92362941
72Abnormality of macular pigmentation (HP:0008002)1.92064376
73Sacral dimple (HP:0000960)1.91425377
74Papillary thyroid carcinoma (HP:0002895)1.90648247
75Sleep apnea (HP:0010535)1.89777788
76Steppage gait (HP:0003376)1.88386828
77Hypoplasia of the iris (HP:0007676)1.88044099
78Hyperacusis (HP:0010780)1.87344391
79Exotropia (HP:0000577)1.84899738
80Wide anterior fontanel (HP:0000260)1.83121007
81Action tremor (HP:0002345)1.82644598
82White forelock (HP:0002211)1.80699815
83Generalized hypotonia (HP:0001290)1.80617047
84Hammertoe (HP:0001765)1.79760319
85Arterial tortuosity (HP:0005116)1.79753019
86Lissencephaly (HP:0001339)1.79116206
87Papilledema (HP:0001085)1.78978794
88Neoplasm of the peripheral nervous system (HP:0100007)1.77681656
89Oligodactyly (HP:0012165)1.77301374
90Vascular tortuosity (HP:0004948)1.77014112
91Amblyopia (HP:0000646)1.76242190
92Abnormality of dentin (HP:0010299)1.74885865
93Visual hallucinations (HP:0002367)1.74485294
94Truncal ataxia (HP:0002078)1.73968122
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73955454
96Febrile seizures (HP:0002373)1.73005099
97Hypothermia (HP:0002045)1.72876438
98Atonic seizures (HP:0010819)1.72695613
99Abnormality of the nasal septum (HP:0000419)1.72674417
100Elfin facies (HP:0004428)1.72506881
101Asymmetry of the thorax (HP:0001555)1.72363394
102Attenuation of retinal blood vessels (HP:0007843)1.72049911
103Alacrima (HP:0000522)1.71564944
104Pachygyria (HP:0001302)1.71547576
105Omphalocele (HP:0001539)1.70583053
106Absence seizures (HP:0002121)1.70479331
107Abnormality of the aortic arch (HP:0012303)1.70375549
108Bowel diverticulosis (HP:0005222)1.70288894
109Hypoplasia of the corpus callosum (HP:0002079)1.70107437
110Poor coordination (HP:0002370)1.70004582
111Broad-based gait (HP:0002136)1.69458447
112Optic nerve hypoplasia (HP:0000609)1.69389615
113Lymphangioma (HP:0100764)1.69096835
114Type II diabetes mellitus (HP:0005978)1.69052013
115Abnormality of the 4th metacarpal (HP:0010012)1.68483896
116Abnormality of the parathyroid morphology (HP:0011766)1.68340824
117Abolished electroretinogram (ERG) (HP:0000550)1.67936917
118Hepatoblastoma (HP:0002884)1.67767070
119Hemivertebrae (HP:0002937)1.67352865
120Broad metatarsal (HP:0001783)1.67327872
121Retinal dysplasia (HP:0007973)1.66681391
122Oligodactyly (hands) (HP:0001180)1.65824353
123Tented upper lip vermilion (HP:0010804)1.64993532
124Menstrual irregularities (HP:0000858)1.63978890
125Renal dysplasia (HP:0000110)1.63973645
126Patchy hypopigmentation of hair (HP:0011365)1.63936224
127Broad ribs (HP:0000885)1.63664310
128Coronal craniosynostosis (HP:0004440)1.63663198
129Abnormality of the corticospinal tract (HP:0002492)1.63193056
130Neoplasm of the heart (HP:0100544)1.62716940
131Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62543807
132Absent frontal sinuses (HP:0002688)1.62412629
133Bronchomalacia (HP:0002780)1.62270659
134Primary atrial arrhythmia (HP:0001692)1.61252581
135Micropenis (HP:0000054)1.60312117
136Anophthalmia (HP:0000528)1.60138142
137Broad palm (HP:0001169)1.59666302
138Supraventricular arrhythmia (HP:0005115)1.59603766
139Thin ribs (HP:0000883)1.59251421
140Medial flaring of the eyebrow (HP:0010747)1.58616223
141Failure to thrive in infancy (HP:0001531)1.58587887
142Abnormal eating behavior (HP:0100738)1.58486701
143Ankle clonus (HP:0011448)1.58321210
144Excessive salivation (HP:0003781)1.57800056
145Drooling (HP:0002307)1.57800056
146Abnormality of the radial head (HP:0003995)1.57684311
147Supraventricular tachycardia (HP:0004755)1.57484405
148Heterochromia iridis (HP:0001100)1.57442327
149Wrist flexion contracture (HP:0001239)1.54543586
150Aplasia involving bones of the upper limbs (HP:0009823)1.54283348
151Aplasia of the phalanges of the hand (HP:0009802)1.54283348
152Aplasia involving bones of the extremities (HP:0009825)1.54283348
153Overgrowth (HP:0001548)1.53997010
154Long toe (HP:0010511)1.53142465
155Abnormality of the fingertips (HP:0001211)1.52131678
156Abnormality of the intervertebral disk (HP:0005108)1.50949258
157Cutaneous finger syndactyly (HP:0010554)1.50897859
158Prolonged QT interval (HP:0001657)1.50690989
159Renovascular hypertension (HP:0100817)1.50155197
160Atrial fibrillation (HP:0005110)1.49654159
161Cutaneous syndactyly (HP:0012725)1.48716967
162Pointed chin (HP:0000307)1.48139216
163Megalocornea (HP:0000485)1.48076943
164Septo-optic dysplasia (HP:0100842)1.47766206
165Enlarged penis (HP:0000040)1.46830447
166Genetic anticipation (HP:0003743)1.46460509
167Broad toe (HP:0001837)1.46240198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.91871246
2SIK33.81222556
3MARK13.62581511
4NTRK22.75154323
5STK242.25735679
6MAP3K102.21932380
7MINK12.19343678
8MAPK132.14310066
9KSR11.97461881
10MAP3K41.87567909
11SIK21.86816140
12PRPF4B1.73542290
13MAP2K71.67122251
14EPHA41.63637646
15PHKG21.59687298
16PHKG11.59687298
17FGFR21.58212240
18MKNK11.57179892
19PDGFRA1.52626397
20TYRO31.49019591
21FGFR31.48317797
22SGK21.45702576
23WNK31.45061680
24MAP4K21.44275274
25PAK31.43078314
26BRD41.39623157
27DYRK21.39591469
28LMTK21.37264691
29PNCK1.36247827
30PRKD31.33992380
31ERBB31.30898355
32SGK2231.30848658
33SGK4941.30848658
34PAK61.28956644
35PRKCH1.28540537
36EEF2K1.28532796
37TNIK1.26544247
38UHMK11.21537968
39RPS6KA41.15294002
40EPHB21.13879249
41RET1.13115214
42SGK31.13040477
43DYRK1A1.11808871
44SIK11.07477701
45TGFBR11.04592492
46PKN21.04252347
47MARK21.03910485
48ROCK11.03166030
49FGFR10.98434995
50MOS0.95271273
51TRIB30.93711764
52TXK0.93128630
53LIMK10.90796821
54MAP3K120.89785952
55CDK50.89427156
56ADRBK10.86421466
57YES10.86261648
58PLK20.85668027
59PKN10.84770992
60EPHA30.83816485
61DMPK0.83548078
62FER0.81675453
63RPS6KA20.81402361
64CAMKK10.80709224
65MAP3K90.79977372
66FGFR40.78586512
67ROCK20.77568840
68ERBB40.76663571
69ERBB20.76181912
70NTRK30.75972387
71PDGFRB0.75932761
72CDK140.75352512
73WEE10.75218100
74EPHB10.74883405
75CDK180.74688661
76DYRK1B0.73704830
77MARK30.72484509
78CSNK1G20.69916018
79TAOK10.68897661
80DAPK20.68827535
81GRK60.67998083
82CAMK2B0.66698956
83MAPK120.66271804
84ILK0.64381703
85MAP3K70.63189329
86TRIM280.62846145
87NLK0.62819890
88MAPK90.62458890
89BMPR1B0.62340317
90SRPK10.61970762
91LATS20.61664063
92BCR0.59952518
93LRRK20.58504292
94CDK150.58396453
95KDR0.57860448
96MAP2K10.57641558
97NTRK10.55408559
98CAMK40.54836181
99CDK30.52413890
100CSNK1A1L0.52023961
101PRKD20.51719170
102PRKCZ0.51414814
103MYLK0.50261792
104GRK10.49476112
105CDK11A0.49431255
106STK30.49086796
107CSNK1G30.48525039
108PRKCG0.47984416
109ITK0.47908425
110FES0.46713732
111NEK60.46535149
112PRKCE0.43118108
113PRKD10.42331207
114TAOK20.41856032
115TLK10.41852606
116FYN0.41814392
117MATK0.40958189
118MKNK20.40897289
119DYRK30.40036919
120MAP2K40.39376621
121MAPK100.38245330
122MAPK80.36581010
123HIPK20.35997369
124CAMK2A0.35948945
125CSNK1G10.35478737
126CDK190.35375798
127PRKAA10.35005503
128KSR20.33084650
129RAF10.32513521
130CSNK1D0.31117258
131ICK0.27509931
132MAPK150.27383786
133RIPK10.27064914
134SGK10.25529900
135EGFR0.24350506
136INSR0.23471878
137CAMK2G0.22734732

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.54509320
2Olfactory transduction_Homo sapiens_hsa047401.77921679
3Endometrial cancer_Homo sapiens_hsa052131.74460055
4Colorectal cancer_Homo sapiens_hsa052101.72286068
5Axon guidance_Homo sapiens_hsa043601.64310309
6Morphine addiction_Homo sapiens_hsa050321.63756878
7Circadian entrainment_Homo sapiens_hsa047131.62045635
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61941230
9Synaptic vesicle cycle_Homo sapiens_hsa047211.55779277
10Dilated cardiomyopathy_Homo sapiens_hsa054141.55421149
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55107441
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54983041
13Nicotine addiction_Homo sapiens_hsa050331.53702346
14GABAergic synapse_Homo sapiens_hsa047271.53428805
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50952430
16Cholinergic synapse_Homo sapiens_hsa047251.47899474
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45134962
18Dopaminergic synapse_Homo sapiens_hsa047281.43776473
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41777207
20Viral myocarditis_Homo sapiens_hsa054161.36527525
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35458819
22Glutamatergic synapse_Homo sapiens_hsa047241.33713743
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32760747
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32720403
25Gap junction_Homo sapiens_hsa045401.27455824
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27161011
27Renin secretion_Homo sapiens_hsa049241.25257446
28Glioma_Homo sapiens_hsa052141.23997302
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22114015
30T cell receptor signaling pathway_Homo sapiens_hsa046601.22075235
31Cardiac muscle contraction_Homo sapiens_hsa042601.21846872
32Insulin secretion_Homo sapiens_hsa049111.18564223
33Basal cell carcinoma_Homo sapiens_hsa052171.17751654
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17563579
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16918927
36Hippo signaling pathway_Homo sapiens_hsa043901.16714495
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16618470
38Oxytocin signaling pathway_Homo sapiens_hsa049211.16522472
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13027660
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12650676
41Wnt signaling pathway_Homo sapiens_hsa043101.11011542
42Serotonergic synapse_Homo sapiens_hsa047261.10021150
43Gastric acid secretion_Homo sapiens_hsa049711.07781362
44Renal cell carcinoma_Homo sapiens_hsa052111.07421691
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06592246
46ErbB signaling pathway_Homo sapiens_hsa040121.05955606
47Salivary secretion_Homo sapiens_hsa049701.05072861
48Focal adhesion_Homo sapiens_hsa045101.03867800
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03455455
50Hedgehog signaling pathway_Homo sapiens_hsa043401.03000501
51Melanogenesis_Homo sapiens_hsa049161.01943091
52Taste transduction_Homo sapiens_hsa047421.01490459
53Long-term potentiation_Homo sapiens_hsa047201.00648107
54Chronic myeloid leukemia_Homo sapiens_hsa052200.97108613
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96720123
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.96110440
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95160575
58Rap1 signaling pathway_Homo sapiens_hsa040150.94456285
59Pancreatic cancer_Homo sapiens_hsa052120.92834837
60Notch signaling pathway_Homo sapiens_hsa043300.91822837
61Choline metabolism in cancer_Homo sapiens_hsa052310.90561352
62Adherens junction_Homo sapiens_hsa045200.89763589
63Calcium signaling pathway_Homo sapiens_hsa040200.88027651
64MAPK signaling pathway_Homo sapiens_hsa040100.87527779
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.87448299
66cAMP signaling pathway_Homo sapiens_hsa040240.87376086
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87254153
68Alcoholism_Homo sapiens_hsa050340.86754777
69Long-term depression_Homo sapiens_hsa047300.86515776
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85418501
71Non-small cell lung cancer_Homo sapiens_hsa052230.85401596
72Protein digestion and absorption_Homo sapiens_hsa049740.85333423
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84512973
74GnRH signaling pathway_Homo sapiens_hsa049120.84433357
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.83009571
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82774272
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82284666
78Circadian rhythm_Homo sapiens_hsa047100.81770935
79Pathways in cancer_Homo sapiens_hsa052000.80749331
80Cocaine addiction_Homo sapiens_hsa050300.80505503
81Ras signaling pathway_Homo sapiens_hsa040140.79721942
82Primary immunodeficiency_Homo sapiens_hsa053400.78650918
83ECM-receptor interaction_Homo sapiens_hsa045120.78536353
84Melanoma_Homo sapiens_hsa052180.78129015
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78121588
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77979723
87Steroid biosynthesis_Homo sapiens_hsa001000.75074833
88VEGF signaling pathway_Homo sapiens_hsa043700.75054862
89Estrogen signaling pathway_Homo sapiens_hsa049150.74877861
90mTOR signaling pathway_Homo sapiens_hsa041500.74844837
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74487739
92Type II diabetes mellitus_Homo sapiens_hsa049300.73685393
93Proteoglycans in cancer_Homo sapiens_hsa052050.73651051
94Dorso-ventral axis formation_Homo sapiens_hsa043200.73271064
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71437207
96Prolactin signaling pathway_Homo sapiens_hsa049170.70677178
97Amphetamine addiction_Homo sapiens_hsa050310.70664230
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70485727
99MicroRNAs in cancer_Homo sapiens_hsa052060.67678668
100Prostate cancer_Homo sapiens_hsa052150.67390055
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67379939
102Insulin signaling pathway_Homo sapiens_hsa049100.66912107
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66603968
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.66527355
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66070896
106Small cell lung cancer_Homo sapiens_hsa052220.65732650
107mRNA surveillance pathway_Homo sapiens_hsa030150.65309118
108Endocytosis_Homo sapiens_hsa041440.64712140
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62819473
110Oocyte meiosis_Homo sapiens_hsa041140.62636748
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62597766
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61884468
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60291918
114Platelet activation_Homo sapiens_hsa046110.59462973
115Prion diseases_Homo sapiens_hsa050200.57050791
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57026481
117Chemokine signaling pathway_Homo sapiens_hsa040620.56953580
118Pancreatic secretion_Homo sapiens_hsa049720.56562044
119Tight junction_Homo sapiens_hsa045300.56269209

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