TRIL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)4.77421731
2L-amino acid import (GO:0043092)4.70234599
3amino acid import (GO:0043090)4.61228038
4dermatan sulfate biosynthetic process (GO:0030208)4.49013355
5dermatan sulfate metabolic process (GO:0030205)4.43215837
6presynaptic membrane organization (GO:0097090)4.41780199
7cell proliferation involved in metanephros development (GO:0072203)4.14357802
8locomotory exploration behavior (GO:0035641)4.11839487
9alanine transport (GO:0032328)4.09527783
10negative regulation of astrocyte differentiation (GO:0048712)4.07426119
11chondroitin sulfate catabolic process (GO:0030207)4.03283805
12astrocyte differentiation (GO:0048708)3.94910362
13cellular potassium ion homeostasis (GO:0030007)3.91871853
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.89421699
15gamma-aminobutyric acid transport (GO:0015812)3.85265213
16sodium ion export (GO:0071436)3.82557204
17negative regulation of smoothened signaling pathway (GO:0045879)3.79941842
18C4-dicarboxylate transport (GO:0015740)3.79413822
19head development (GO:0060322)3.72700865
20postsynaptic membrane organization (GO:0001941)3.67784222
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.60393613
22peripheral nervous system axon ensheathment (GO:0032292)3.55621580
23myelination in peripheral nervous system (GO:0022011)3.55621580
24cell communication by electrical coupling (GO:0010644)3.48922188
25cell proliferation involved in kidney development (GO:0072111)3.45907936
26neuron cell-cell adhesion (GO:0007158)3.32860217
27synaptic vesicle maturation (GO:0016188)3.30454823
28neuron recognition (GO:0008038)3.30306710
29cellular response to cholesterol (GO:0071397)3.26169758
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.25784134
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.24927801
32mesenchymal cell proliferation (GO:0010463)3.22328855
33kidney mesenchyme development (GO:0072074)3.21986017
34glutamate secretion (GO:0014047)3.21819018
35outer ear morphogenesis (GO:0042473)3.20664572
36regulation of synaptic vesicle exocytosis (GO:2000300)3.17815256
37metanephric mesenchyme development (GO:0072075)3.16470782
38ovulation cycle (GO:0042698)3.14563914
39neuronal action potential propagation (GO:0019227)3.13344411
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.12312488
41axon extension involved in axon guidance (GO:0048846)3.12312488
42cellular sodium ion homeostasis (GO:0006883)3.07572471
43mesenchymal cell differentiation involved in renal system development (GO:2001012)3.07219307
44mesenchymal cell differentiation involved in kidney development (GO:0072161)3.07219307
45regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06599863
46negative regulation of sodium ion transport (GO:0010766)3.06357093
47glial cell proliferation (GO:0014009)3.06044191
48L-serine transport (GO:0015825)3.05879464
49synaptic vesicle exocytosis (GO:0016079)3.05785445
50astrocyte development (GO:0014002)3.05681778
51lens fiber cell development (GO:0070307)3.04347512
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03244715
53potassium ion import (GO:0010107)3.01314859
54neuronal ion channel clustering (GO:0045161)3.00764344
55regulation of neuronal synaptic plasticity (GO:0048168)2.98914503
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98842919
57central nervous system myelination (GO:0022010)2.98305830
58axon ensheathment in central nervous system (GO:0032291)2.98305830
59neuromuscular process controlling balance (GO:0050885)2.96602724
60potassium ion homeostasis (GO:0055075)2.96578088
61auditory behavior (GO:0031223)2.95605958
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93109051
63synaptic transmission, glutamatergic (GO:0035249)2.93104361
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92344387
65cerebellar granule cell differentiation (GO:0021707)2.92256924
66mechanosensory behavior (GO:0007638)2.91981836
67craniofacial suture morphogenesis (GO:0097094)2.91490273
68response to auditory stimulus (GO:0010996)2.91409057
69regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.90089742
70regulation of astrocyte differentiation (GO:0048710)2.89256487
71axonal fasciculation (GO:0007413)2.88970574
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88210324
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87817570
74dendrite morphogenesis (GO:0048813)2.86123501
75protein localization to synapse (GO:0035418)2.85482459
76dendritic spine morphogenesis (GO:0060997)2.84531185
77cochlea morphogenesis (GO:0090103)2.83653095
78neurotransmitter-gated ion channel clustering (GO:0072578)2.82774442
79neuron projection regeneration (GO:0031102)2.80700366
80regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80075987
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79608520
82hindlimb morphogenesis (GO:0035137)2.77705638
83metanephric tubule development (GO:0072170)2.77665276
84metanephric nephron tubule development (GO:0072234)2.77665276
85blood vessel maturation (GO:0001955)2.75535033
86cerebellar Purkinje cell layer development (GO:0021680)2.75487016
87glutamate receptor signaling pathway (GO:0007215)2.75471333
88limb bud formation (GO:0060174)2.75453506
89notochord development (GO:0030903)2.74094740
90presynaptic membrane assembly (GO:0097105)2.73569286
91mesenchyme morphogenesis (GO:0072132)2.73176776
92cochlea development (GO:0090102)2.72496285
93atrial cardiac muscle cell action potential (GO:0086014)2.72432708
94positive regulation of synapse maturation (GO:0090129)2.72043840
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72015145
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71430226
97metanephric epithelium development (GO:0072207)2.71192015
98collecting duct development (GO:0072044)2.71090520
99neurotransmitter secretion (GO:0007269)2.70791166
100regulation of synaptic vesicle transport (GO:1902803)2.70408288
101regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.70335361
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69537418
103photoreceptor cell differentiation (GO:0046530)2.69209682
104eye photoreceptor cell differentiation (GO:0001754)2.69209682
105oligodendrocyte differentiation (GO:0048709)2.67675794
106cell differentiation involved in kidney development (GO:0061005)2.67407466
107exploration behavior (GO:0035640)2.66250966
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.65421494
109regulation of respiratory system process (GO:0044065)2.64785531
110regulation of smoothened signaling pathway (GO:0008589)2.64587170
111epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.64172824
112negative regulation of axon extension involved in axon guidance (GO:0048843)2.63324320
113negative regulation of catenin import into nucleus (GO:0035414)2.63243167
114mesonephros development (GO:0001823)2.62641128
115regulation of glutamate receptor signaling pathway (GO:1900449)2.62426759
116synaptic vesicle endocytosis (GO:0048488)2.61525144
117positive regulation of synapse assembly (GO:0051965)2.60888060
118negative regulation of glial cell differentiation (GO:0045686)2.60264569
119mesenchymal-epithelial cell signaling (GO:0060638)2.59962870
120regulation of axon extension involved in axon guidance (GO:0048841)2.59564076
121cell communication involved in cardiac conduction (GO:0086065)2.57995335
122cellular response to sterol (GO:0036315)2.57381433
123vocalization behavior (GO:0071625)2.57287716
124cranial nerve development (GO:0021545)2.57031906
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.56701623
126paraxial mesoderm development (GO:0048339)2.56300301
127skeletal muscle organ development (GO:0060538)2.56241093
128proximal/distal pattern formation (GO:0009954)2.56049674
129embryonic skeletal joint morphogenesis (GO:0060272)2.55586433
130regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54937411
131regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54837669
132regulation of synapse structural plasticity (GO:0051823)2.53460169
133cGMP-mediated signaling (GO:0019934)2.51103386
134cell-cell signaling involved in cell fate commitment (GO:0045168)2.51046413
135axon extension (GO:0048675)2.48808643
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48122997
137acidic amino acid transport (GO:0015800)2.47984259
138serine transport (GO:0032329)2.47713251
139membrane assembly (GO:0071709)2.46982309
140branching involved in ureteric bud morphogenesis (GO:0001658)2.46556624
141innervation (GO:0060384)2.46376909
142developmental induction (GO:0031128)2.46364542
143metanephric nephron epithelium development (GO:0072243)2.46281383
144cerebral cortex radially oriented cell migration (GO:0021799)2.45798441
145layer formation in cerebral cortex (GO:0021819)2.45162903
146camera-type eye morphogenesis (GO:0048593)2.45095687
147glomerulus development (GO:0032835)2.44712916
148neuroblast proliferation (GO:0007405)2.44237569
149neurotransmitter uptake (GO:0001504)2.44065997
150central nervous system projection neuron axonogenesis (GO:0021952)2.44049564
151neuromuscular junction development (GO:0007528)2.43790578
152transmission of nerve impulse (GO:0019226)2.42140548
153regulation of axon guidance (GO:1902667)2.39932555
154cell migration in hindbrain (GO:0021535)2.39230230
155positive regulation of dendrite development (GO:1900006)2.37947527
156glial cell differentiation (GO:0010001)2.37138500
157myelination (GO:0042552)2.35703033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.90407762
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.24117779
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.15698157
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09703554
5SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.99339617
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98524186
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.89957295
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87484100
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87484100
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87095617
11GBX2_23144817_ChIP-Seq_PC3_Human2.75541575
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74185228
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73194794
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70815609
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62362239
16AR_21572438_ChIP-Seq_LNCaP_Human2.53139594
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48646439
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.43374985
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.34568275
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32351934
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.27544236
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.16605289
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14891722
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10413522
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.08404796
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00783382
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97215159
28DROSHA_22980978_ChIP-Seq_HELA_Human1.81667620
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79967014
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79342195
31RING1B_27294783_Chip-Seq_ESCs_Mouse1.66701428
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65246725
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.61537919
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55584955
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55380675
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52859355
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52837287
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.52135577
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48901768
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47763447
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46739381
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45333580
43P300_19829295_ChIP-Seq_ESCs_Human1.43209229
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42973201
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42650706
46TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.39260647
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38340442
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.37577742
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37061489
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.36939950
51SMAD4_21799915_ChIP-Seq_A2780_Human1.36388127
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35557041
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.34001192
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33893943
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32537561
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31946061
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31515503
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30667176
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.30244226
60TP53_18474530_ChIP-ChIP_U2OS_Human1.28398117
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.28368142
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28211451
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27142537
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26769565
65REST_21632747_ChIP-Seq_MESCs_Mouse1.26727353
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25535755
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.23713653
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23318896
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.21880420
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.20511336
71BCAT_22108803_ChIP-Seq_LS180_Human1.20509435
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20456598
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20456598
74TP53_16413492_ChIP-PET_HCT116_Human1.20266165
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.19798253
76KDM2B_26808549_Chip-Seq_K562_Human1.19381330
77FUS_26573619_Chip-Seq_HEK293_Human1.19006153
78* RXR_22108803_ChIP-Seq_LS180_Human1.18110784
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17433722
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.17119816
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17057247
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16962760
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16693053
84ZNF274_21170338_ChIP-Seq_K562_Hela1.15556753
85AR_19668381_ChIP-Seq_PC3_Human1.15159717
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14705796
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14390205
88AR_25329375_ChIP-Seq_VCAP_Human1.13152416
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12097153
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11472549
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.10524818
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09383575
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07980176
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06063818
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.06050198
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05052001
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.04376350
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04309494
99STAT3_23295773_ChIP-Seq_U87_Human1.04302142
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04116703
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03639980
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02378151
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00431744
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00394532
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00277722
106AHR_22903824_ChIP-Seq_MCF-7_Human1.00163959
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.99950066
108SOX9_26525672_Chip-Seq_HEART_Mouse0.97052345
109* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96873192
110RNF2_27304074_Chip-Seq_NSC_Mouse0.96598492
111TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96514635
112TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95883230
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95793732
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93806526
115RARB_27405468_Chip-Seq_BRAIN_Mouse0.93543184
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93444733
117* RUNX2_22187159_ChIP-Seq_PCA_Human0.92951502
118POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92844221
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92367176
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92200031
121TAF15_26573619_Chip-Seq_HEK293_Human0.92148342
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91409971
123CTCF_27219007_Chip-Seq_Bcells_Human0.91263681
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.91035946
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90967758
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90898631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.59356106
2MP0003942_abnormal_urinary_system2.49269365
3MP0003136_yellow_coat_color2.48651906
4MP0004858_abnormal_nervous_system2.42656502
5MP0004859_abnormal_synaptic_plasticity2.41985881
6MP0009250_abnormal_appendicular_skeleto2.37902445
7MP0002249_abnormal_larynx_morphology2.36214412
8MP0000049_abnormal_middle_ear2.33353686
9MP0002938_white_spotting2.17842876
10MP0003385_abnormal_body_wall2.12745587
11MP0004885_abnormal_endolymph2.12505946
12MP0010030_abnormal_orbit_morphology2.10417047
13MP0000534_abnormal_ureter_morphology2.10401648
14MP0003122_maternal_imprinting2.08716002
15MP0005171_absent_coat_pigmentation2.08005390
16MP0005646_abnormal_pituitary_gland2.00203507
17MP0009384_cardiac_valve_regurgitation1.95936588
18MP0003690_abnormal_glial_cell1.95430568
19MP0003123_paternal_imprinting1.92568872
20MP0001486_abnormal_startle_reflex1.90440414
21MP0001299_abnormal_eye_distance/1.88225252
22MP0003635_abnormal_synaptic_transmissio1.87776553
23MP0005503_abnormal_tendon_morphology1.87326866
24MP0005275_abnormal_skin_tensile1.80079842
25MP0003941_abnormal_skin_development1.79616049
26MP0000778_abnormal_nervous_system1.79375697
27MP0003938_abnormal_ear_development1.72846304
28MP0005423_abnormal_somatic_nervous1.68760797
29MP0003880_abnormal_central_pattern1.66896572
30MP0000428_abnormal_craniofacial_morphol1.64354580
31MP0003937_abnormal_limbs/digits/tail_de1.60326149
32MP0002735_abnormal_chemical_nociception1.59841051
33MP0002089_abnormal_postnatal_growth/wei1.59697614
34MP0009780_abnormal_chondrocyte_physiolo1.50501449
35MP0009046_muscle_twitch1.48344162
36MP0001984_abnormal_olfaction1.43663239
37MP0004270_analgesia1.43203699
38MP0003878_abnormal_ear_physiology1.43175617
39MP0005377_hearing/vestibular/ear_phenot1.43175617
40MP0002653_abnormal_ependyma_morphology1.42426576
41MP0002233_abnormal_nose_morphology1.42311549
42MP0003755_abnormal_palate_morphology1.40193675
43MP0001293_anophthalmia1.40074344
44MP0009745_abnormal_behavioral_response1.39549371
45MP0003115_abnormal_respiratory_system1.36192296
46MP0002063_abnormal_learning/memory/cond1.36170950
47MP0003121_genomic_imprinting1.34390924
48MP0002064_seizures1.34059052
49MP0004272_abnormal_basement_membrane1.32308069
50MP0008569_lethality_at_weaning1.30014346
51MP0005623_abnormal_meninges_morphology1.29974158
52MP0002572_abnormal_emotion/affect_behav1.29246674
53MP0002116_abnormal_craniofacial_bone1.28735731
54MP0002557_abnormal_social/conspecific_i1.27148629
55MP0002282_abnormal_trachea_morphology1.25516894
56MP0002932_abnormal_joint_morphology1.25328848
57MP0001970_abnormal_pain_threshold1.24677090
58MP0005409_darkened_coat_color1.23317351
59MP0003935_abnormal_craniofacial_develop1.20833731
60MP0000462_abnormal_digestive_system1.19753895
61MP0001440_abnormal_grooming_behavior1.19523409
62MP0003634_abnormal_glial_cell1.19291318
63MP0000631_abnormal_neuroendocrine_gland1.18882756
64MP0005248_abnormal_Harderian_gland1.18605832
65MP0001968_abnormal_touch/_nociception1.17624033
66MP0003279_aneurysm1.17579831
67MP0009053_abnormal_anal_canal1.17211085
68MP0002736_abnormal_nociception_after1.16994780
69MP0000955_abnormal_spinal_cord1.16869852
70MP0002109_abnormal_limb_morphology1.13189907
71MP0004134_abnormal_chest_morphology1.12931162
72MP0001485_abnormal_pinna_reflex1.12250178
73MP0002067_abnormal_sensory_capabilities1.12033844
74MP0005508_abnormal_skeleton_morphology1.11997794
75MP0001177_atelectasis1.10601316
76MP0001502_abnormal_circadian_rhythm1.06882798
77MP0002254_reproductive_system_inflammat1.06755510
78MP0004811_abnormal_neuron_physiology1.05619373
79MP0002184_abnormal_innervation1.04859436
80MP0006276_abnormal_autonomic_nervous1.04413254
81MP0002272_abnormal_nervous_system1.03416907
82MP0000026_abnormal_inner_ear1.02883496
83MP0000762_abnormal_tongue_morphology1.02873283
84MP0003119_abnormal_digestive_system1.02823358
85MP0002152_abnormal_brain_morphology1.02273201
86MP0002734_abnormal_mechanical_nocicepti1.02253199
87MP0003633_abnormal_nervous_system1.01581179
88MP0002066_abnormal_motor_capabilities/c1.01160616
89MP0002177_abnormal_outer_ear1.00182224
90MP0003283_abnormal_digestive_organ0.99729470
91MP0001963_abnormal_hearing_physiology0.99693175
92MP0000432_abnormal_head_morphology0.99255300
93MP0002882_abnormal_neuron_morphology0.98107004
94MP0002108_abnormal_muscle_morphology0.97952241
95MP0000163_abnormal_cartilage_morphology0.97883635
96MP0001958_emphysema0.97676345
97MP0001270_distended_abdomen0.95292574
98MP0000579_abnormal_nail_morphology0.94844474
99MP0000751_myopathy0.92311078
100MP0003861_abnormal_nervous_system0.92039968
101MP0002234_abnormal_pharynx_morphology0.91847624
102MP0000537_abnormal_urethra_morphology0.90663416
103MP0003632_abnormal_nervous_system0.90522737
104MP0003631_nervous_system_phenotype0.89356648
105MP0002115_abnormal_skeleton_extremities0.87797741
106MP0006292_abnormal_olfactory_placode0.87301821
107MP0002638_abnormal_pupillary_reflex0.86433806
108MP0003705_abnormal_hypodermis_morpholog0.86355328
109MP0003329_amyloid_beta_deposits0.85930350
110MP0001346_abnormal_lacrimal_gland0.85581357
111MP0000920_abnormal_myelination0.85253266
112MP0003137_abnormal_impulse_conducting0.85171996
113MP0002733_abnormal_thermal_nociception0.83995862
114MP0002114_abnormal_axial_skeleton0.83781816
115MP0008438_abnormal_cutaneous_collagen0.83628411
116MP0003787_abnormal_imprinting0.83097948
117MP0008789_abnormal_olfactory_epithelium0.82188991
118MP0005499_abnormal_olfactory_system0.82027905
119MP0005394_taste/olfaction_phenotype0.82027905
120MP0002752_abnormal_somatic_nervous0.81589526
121MP0001501_abnormal_sleep_pattern0.79098502
122MP0005167_abnormal_blood-brain_barrier0.77072197

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)4.77429094
2Aplasia involving bones of the upper limbs (HP:0009823)4.77429094
3Aplasia of the phalanges of the hand (HP:0009802)4.77429094
4Short 4th metacarpal (HP:0010044)4.53744790
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.53744790
6Megalencephaly (HP:0001355)3.74298232
7Midline defect of the nose (HP:0004122)3.60497024
8Myokymia (HP:0002411)3.56239368
9Abnormality of the 4th metacarpal (HP:0010012)3.49447109
10Synostosis involving the elbow (HP:0003938)3.39895788
11Humeroradial synostosis (HP:0003041)3.39895788
12Hypoplastic left heart (HP:0004383)3.30530907
13Action tremor (HP:0002345)3.21152971
14Abnormality of the parietal bone (HP:0002696)3.00748468
15Anteriorly placed anus (HP:0001545)2.96058112
16Vitreoretinal degeneration (HP:0000655)2.88234291
17Abnormality of the nasolacrimal system (HP:0000614)2.87613730
18Broad metatarsal (HP:0001783)2.87199167
19Abnormality of the ischium (HP:0003174)2.87076574
20Hepatoblastoma (HP:0002884)2.82083139
21Microglossia (HP:0000171)2.81918138
22Abnormality of the middle phalanges of the toes (HP:0010183)2.79150745
23Obstructive sleep apnea (HP:0002870)2.74579361
24Focal seizures (HP:0007359)2.73408706
25Coronal craniosynostosis (HP:0004440)2.69544557
26Cutaneous syndactyly (HP:0012725)2.65198475
27Abnormality of the lacrimal duct (HP:0011481)2.63586996
28Trigonocephaly (HP:0000243)2.63564356
29Hypoplastic heart (HP:0001961)2.63179362
30Bladder diverticulum (HP:0000015)2.62957448
31Cutaneous finger syndactyly (HP:0010554)2.60510286
32Short middle phalanx of the 5th finger (HP:0004220)2.59942185
33Shallow orbits (HP:0000586)2.59623583
34Split foot (HP:0001839)2.57959367
35Anophthalmia (HP:0000528)2.55880599
36Broad toe (HP:0001837)2.53542048
37Infantile muscular hypotonia (HP:0008947)2.51275492
38Nasolacrimal duct obstruction (HP:0000579)2.50647824
39Atonic seizures (HP:0010819)2.42839495
40Hypoplastic ischia (HP:0003175)2.39283046
41Bowel diverticulosis (HP:0005222)2.39234614
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38607678
43Hemiparesis (HP:0001269)2.37306669
44Premature rupture of membranes (HP:0001788)2.33511797
45Mixed hearing impairment (HP:0000410)2.32453616
46Renal duplication (HP:0000075)2.31531897
47Aplasia/Hypoplasia of the clavicles (HP:0006710)2.30115005
48Diastasis recti (HP:0001540)2.29882428
49Short hallux (HP:0010109)2.29344336
50Tracheomalacia (HP:0002779)2.28976664
51Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.25011713
52Alacrima (HP:0000522)2.24064835
53Fibular aplasia (HP:0002990)2.22192851
54Overriding aorta (HP:0002623)2.21983742
55Thin ribs (HP:0000883)2.20088845
56Symphalangism affecting the phalanges of the hand (HP:0009773)2.19818374
57Hemiplegia (HP:0002301)2.19011173
58Long nose (HP:0003189)2.18932015
59Renovascular hypertension (HP:0100817)2.18429130
60Morphological abnormality of the middle ear (HP:0008609)2.18364184
61Abnormality of the phalanges of the 5th finger (HP:0004213)2.14591966
62Sleep apnea (HP:0010535)2.13816325
63Akinesia (HP:0002304)2.11453333
64Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11019177
65Partial duplication of the phalanx of hand (HP:0009999)2.09084770
66Supernumerary bones of the axial skeleton (HP:0009144)2.07234903
67Turricephaly (HP:0000262)2.07189903
68Febrile seizures (HP:0002373)2.03377575
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.01553076
70Insomnia (HP:0100785)2.01374507
71Short clavicles (HP:0000894)2.00937674
72Broad hallux (HP:0010055)1.99156299
73Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.98126379
74Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.97796321
75Hyperacusis (HP:0010780)1.96493186
76Narrow nasal bridge (HP:0000446)1.96296020
77Ectopic anus (HP:0004397)1.95238288
78Broad thumb (HP:0011304)1.95232891
79Myelomeningocele (HP:0002475)1.94747821
80Abnormality of binocular vision (HP:0011514)1.93178405
81Diplopia (HP:0000651)1.93178405
82Neonatal short-limb short stature (HP:0008921)1.92811016
83Abnormality of the middle phalanges of the hand (HP:0009833)1.92440964
84Overgrowth (HP:0001548)1.91825786
85Ankle clonus (HP:0011448)1.91456805
86Supernumerary ribs (HP:0005815)1.90589818
87Abnormal eating behavior (HP:0100738)1.90237097
88Broad ribs (HP:0000885)1.88917904
89Broad alveolar ridges (HP:0000187)1.88170270
90Decreased lacrimation (HP:0000633)1.87931792
91Bifid tongue (HP:0010297)1.87033811
92Abnormality of secondary sexual hair (HP:0009888)1.85599163
93Abnormality of the axillary hair (HP:0100134)1.85599163
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.84592268
95Adactyly (HP:0009776)1.83192732
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82735152
97Mild short stature (HP:0003502)1.82714058
98Partial duplication of thumb phalanx (HP:0009944)1.82181960
99Broad long bones (HP:0005622)1.82057214
100Exostoses (HP:0100777)1.81546106
101Annular pancreas (HP:0001734)1.81398705
102Preaxial foot polydactyly (HP:0001841)1.81016044
103Abnormality of the diencephalon (HP:0010662)1.80779435
104Peripheral hypomyelination (HP:0007182)1.80200066
105Generalized tonic-clonic seizures (HP:0002069)1.80093281
106Pseudobulbar signs (HP:0002200)1.79565913
107Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.78498836
108Arnold-Chiari malformation (HP:0002308)1.78159076
109Oligodactyly (HP:0012165)1.77876463
110Aortic dissection (HP:0002647)1.77502878
111Rib fusion (HP:0000902)1.77298529
112Vascular tortuosity (HP:0004948)1.77200274
113Skull defect (HP:0001362)1.77172808
114Narrow palate (HP:0000189)1.76611231
115Bronchomalacia (HP:0002780)1.75551328
116Abnormality of incisor morphology (HP:0011063)1.75488450
117Elfin facies (HP:0004428)1.75008778
118Soft skin (HP:0000977)1.74918387
119Bilateral microphthalmos (HP:0007633)1.74432956
120Aplasia/Hypoplasia of the fibula (HP:0006492)1.73917909
121Neurofibrillary tangles (HP:0002185)1.73079245
122Bell-shaped thorax (HP:0001591)1.72896073
123Epileptic encephalopathy (HP:0200134)1.72169374
124Atrophic scars (HP:0001075)1.71290467
125Broad finger (HP:0001500)1.71208883
126Genu recurvatum (HP:0002816)1.70875580
127Cerebral inclusion bodies (HP:0100314)1.70384948
128Short middle phalanx of finger (HP:0005819)1.69747978
129Cupped ear (HP:0000378)1.69678876
130Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.69560299
131Limited hip movement (HP:0008800)1.69495055
132Neoplasm of the heart (HP:0100544)1.68895964
133Synostosis of carpal bones (HP:0005048)1.68451118
134Abnormality of the nasal septum (HP:0000419)1.68092295
135Focal motor seizures (HP:0011153)1.67268583
136Potter facies (HP:0002009)1.66775265
137Facial shape deformation (HP:0011334)1.66775265
138Wide anterior fontanel (HP:0000260)1.66417250
139Buphthalmos (HP:0000557)1.65791338
140Renal hypoplasia (HP:0000089)1.65371244
141Deviation of the hallux (HP:0010051)1.65243568
142Septo-optic dysplasia (HP:0100842)1.63358426
143Truncal ataxia (HP:0002078)1.62924138
144Hallux valgus (HP:0001822)1.62854414
145Fibular hypoplasia (HP:0003038)1.61248668
146Missing ribs (HP:0000921)1.60894966
147Choanal stenosis (HP:0000452)1.60675310
148Broad phalanx (HP:0006009)1.59296518
149Hyperextensible skin (HP:0000974)1.58413888
150Calcaneovalgus deformity (HP:0001848)1.57757539
151Arterial tortuosity (HP:0005116)1.57280973
152Papilledema (HP:0001085)1.54294520
153Lymphangioma (HP:0100764)1.53811698
154Protrusio acetabuli (HP:0003179)1.53282350
155Abnormality of dentin (HP:0010299)1.53225133
156Ulnar bowing (HP:0003031)1.52339599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.18695929
2TNIK4.02668707
3CASK3.56737921
4EPHA43.46829569
5MAPK132.81787190
6RIPK12.70139391
7NTRK22.59405969
8PHKG12.53625995
9PHKG22.53625995
10NTRK32.51925686
11PNCK2.46233167
12LMTK22.39411719
13SIK12.09298164
14PDGFRA2.00952353
15FGFR21.96654213
16TYRO31.93743272
17MUSK1.87248276
18LATS11.85316607
19DDR21.65891486
20EPHB21.49190414
21MAPK151.48958179
22TRIB31.45592597
23KSR11.35678870
24WNK11.33610476
25NEK61.32480028
26SGK21.32279749
27MAP3K91.30565038
28PRKCH1.29344805
29CAMK1G1.23840705
30FGFR11.22079359
31PAK61.21243582
32MINK11.20215547
33NTRK11.19087641
34MAP3K41.18376552
35MARK11.16400930
36CAMK2B1.14272543
37PRKD21.13924352
38LATS21.12824280
39SGK4941.10444386
40SGK2231.10444386
41ARAF1.10341951
42EPHA31.09506789
43DMPK1.08142945
44DAPK21.06316723
45PINK11.06307593
46CDK31.02383680
47STK38L1.01704665
48SGK31.01449324
49PRPF4B0.98858032
50MAP3K100.98114318
51PDGFRB0.97155422
52ROCK10.96484419
53ICK0.96086698
54CDK80.89830793
55PRKCG0.89107437
56FES0.88351953
57PRKCE0.87926395
58MKNK20.87863685
59ROCK20.86974466
60ERBB20.86755069
61PAK30.82918164
62ADRBK10.82376448
63DYRK1A0.82145703
64PAK20.82077578
65TAOK20.81274392
66MAP2K70.80865489
67RET0.80237513
68STK380.77334858
69CDK140.75035255
70MARK30.74768304
71CAMK2D0.74666577
72MAPK100.73542430
73CDC42BPA0.72096604
74MAPK70.72050001
75DYRK20.71510486
76FGFR40.68877752
77CDK50.68810786
78CAMK1D0.67531502
79BMX0.65135623
80PLK20.64808570
81YES10.64521165
82FGR0.63779110
83MKNK10.63346459
84PKN20.63006170
85BRSK10.60146663
86UHMK10.58688742
87BRD40.58603167
88TSSK60.58590467
89NUAK10.58381968
90PKN10.57305537
91LIMK10.56614734
92CAMK2A0.56558009
93MAP2K40.55643698
94PTK20.55302789
95CAMKK10.55140645
96CDK120.53474158
97GRK50.53174005
98RPS6KA30.52511678
99SRC0.52501975
100PRKD10.50569496
101TESK10.50254330
102SGK10.49071143
103PIK3CA0.48870027
104MOS0.48768961
105IGF1R0.47789448
106ERBB40.47392185
107CDK150.46479471
108CDK180.45939069
109STK390.44127229
110WNK40.43694575
111PRKCZ0.43298663
112CAMK2G0.42855105
113PRKG10.42230848
114INSRR0.42153212
115PRKDC0.41041279
116PRKAA20.40719408
117KSR20.40464272
118MTOR0.38234111
119CDK11A0.37612862
120TNK20.37569369
121STK110.37422858
122MAPK120.37264396
123CAMK10.37179547
124MARK20.36746138
125MAP3K70.36744983
126CSNK1G20.36474516
127AKT30.36395481
128FYN0.36390898
129CSNK1E0.36207340
130CAMK40.36074574
131CSNK1G10.34649966

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.78274152
2Fatty acid biosynthesis_Homo sapiens_hsa000612.93820957
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65643604
4Basal cell carcinoma_Homo sapiens_hsa052172.47025987
5Nicotine addiction_Homo sapiens_hsa050332.45007801
6Hedgehog signaling pathway_Homo sapiens_hsa043402.09410932
7Glutamatergic synapse_Homo sapiens_hsa047242.07725759
8GABAergic synapse_Homo sapiens_hsa047271.84242838
9Circadian entrainment_Homo sapiens_hsa047131.79544302
10Salivary secretion_Homo sapiens_hsa049701.66010708
11Morphine addiction_Homo sapiens_hsa050321.65772873
12Gastric acid secretion_Homo sapiens_hsa049711.65496755
13Insulin secretion_Homo sapiens_hsa049111.65147094
14Axon guidance_Homo sapiens_hsa043601.62441054
15Melanogenesis_Homo sapiens_hsa049161.52271109
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47514122
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41960991
18Cocaine addiction_Homo sapiens_hsa050301.37966393
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36331161
20Long-term potentiation_Homo sapiens_hsa047201.35757757
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34790921
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34235880
23Amphetamine addiction_Homo sapiens_hsa050311.33922871
24Fatty acid metabolism_Homo sapiens_hsa012121.33836899
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32173033
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32049282
27Long-term depression_Homo sapiens_hsa047301.30236377
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27865202
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27849552
30Dorso-ventral axis formation_Homo sapiens_hsa043201.27509054
31Hippo signaling pathway_Homo sapiens_hsa043901.26004825
32Wnt signaling pathway_Homo sapiens_hsa043101.24458114
33Calcium signaling pathway_Homo sapiens_hsa040201.22935683
34Olfactory transduction_Homo sapiens_hsa047401.21483347
35cAMP signaling pathway_Homo sapiens_hsa040241.19284520
36Renin secretion_Homo sapiens_hsa049241.17985765
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17807511
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16864631
39Gap junction_Homo sapiens_hsa045401.14588549
40Cholinergic synapse_Homo sapiens_hsa047251.14126096
41Steroid biosynthesis_Homo sapiens_hsa001001.13853866
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07875652
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.07324747
44Dilated cardiomyopathy_Homo sapiens_hsa054141.06738181
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06660859
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05911562
47Dopaminergic synapse_Homo sapiens_hsa047281.04224795
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98790563
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98528952
50Glioma_Homo sapiens_hsa052140.96060643
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95913259
52Taste transduction_Homo sapiens_hsa047420.92996635
53GnRH signaling pathway_Homo sapiens_hsa049120.92378263
54Bile secretion_Homo sapiens_hsa049760.91154518
55Prion diseases_Homo sapiens_hsa050200.90505846
56Serotonergic synapse_Homo sapiens_hsa047260.90051113
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88099883
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85986590
59Thyroid hormone synthesis_Homo sapiens_hsa049180.84338347
60Oxytocin signaling pathway_Homo sapiens_hsa049210.83955141
61Proteoglycans in cancer_Homo sapiens_hsa052050.83738778
62Melanoma_Homo sapiens_hsa052180.79328679
63ECM-receptor interaction_Homo sapiens_hsa045120.78598496
64Rap1 signaling pathway_Homo sapiens_hsa040150.78534762
65Pancreatic secretion_Homo sapiens_hsa049720.77360759
66TGF-beta signaling pathway_Homo sapiens_hsa043500.76884198
67Choline metabolism in cancer_Homo sapiens_hsa052310.76439186
68Estrogen signaling pathway_Homo sapiens_hsa049150.76100096
69Histidine metabolism_Homo sapiens_hsa003400.74580030
70Oocyte meiosis_Homo sapiens_hsa041140.73114436
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71763941
72Focal adhesion_Homo sapiens_hsa045100.71373232
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70961894
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70868437
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69252625
76Vitamin B6 metabolism_Homo sapiens_hsa007500.69174285
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.67989516
78Mineral absorption_Homo sapiens_hsa049780.67913587
79Adherens junction_Homo sapiens_hsa045200.67263806
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67196706
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67142541
82Circadian rhythm_Homo sapiens_hsa047100.65331900
83Fatty acid degradation_Homo sapiens_hsa000710.65275716
84ErbB signaling pathway_Homo sapiens_hsa040120.65028898
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63546205
86Notch signaling pathway_Homo sapiens_hsa043300.63296504
87Ovarian steroidogenesis_Homo sapiens_hsa049130.63094797
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.62701229
89Protein digestion and absorption_Homo sapiens_hsa049740.62138264
90Cardiac muscle contraction_Homo sapiens_hsa042600.61124735
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.58278572
92Synaptic vesicle cycle_Homo sapiens_hsa047210.58055504
93Arginine and proline metabolism_Homo sapiens_hsa003300.57294260
94MAPK signaling pathway_Homo sapiens_hsa040100.56446691
95Lysine degradation_Homo sapiens_hsa003100.56117535
96beta-Alanine metabolism_Homo sapiens_hsa004100.55453016
97Colorectal cancer_Homo sapiens_hsa052100.55361308
98Prostate cancer_Homo sapiens_hsa052150.55172386
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55139117
100Tight junction_Homo sapiens_hsa045300.54098966
101Glucagon signaling pathway_Homo sapiens_hsa049220.53936770
102PPAR signaling pathway_Homo sapiens_hsa033200.53674837
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52933770
104Pathways in cancer_Homo sapiens_hsa052000.50121743
105Ras signaling pathway_Homo sapiens_hsa040140.49748924
106MicroRNAs in cancer_Homo sapiens_hsa052060.49107868
107VEGF signaling pathway_Homo sapiens_hsa043700.48642900
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47271069
109Renal cell carcinoma_Homo sapiens_hsa052110.46194059
110AMPK signaling pathway_Homo sapiens_hsa041520.45755863
111Amoebiasis_Homo sapiens_hsa051460.44206832
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44093472
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41828650
114Type II diabetes mellitus_Homo sapiens_hsa049300.41717031
115Inositol phosphate metabolism_Homo sapiens_hsa005620.40787272
116African trypanosomiasis_Homo sapiens_hsa051430.40063539
117Endometrial cancer_Homo sapiens_hsa052130.39869365

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