TRIM10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemoglobin metabolic process (GO:0020027)9.89617563
2response to methylmercury (GO:0051597)8.68532730
3erythrocyte development (GO:0048821)7.99685350
4tetrapyrrole metabolic process (GO:0033013)7.45648658
5response to insecticide (GO:0017085)7.18949494
6response to lead ion (GO:0010288)6.90634229
7pigment biosynthetic process (GO:0046148)6.53700752
8regulation of response to osmotic stress (GO:0047484)5.78710294
9disruption of cells of other organism (GO:0044364)5.41372956
10killing of cells of other organism (GO:0031640)5.41372956
11pigment metabolic process (GO:0042440)5.38515849
12myeloid cell development (GO:0061515)5.25679155
13mucosal immune response (GO:0002385)5.16100308
14defense response to fungus (GO:0050832)5.08811126
15one-carbon compound transport (GO:0019755)5.04992094
16very-low-density lipoprotein particle assembly (GO:0034379)4.84291596
17organ or tissue specific immune response (GO:0002251)4.83093662
18negative regulation of erythrocyte differentiation (GO:0045647)4.78917906
19* erythrocyte differentiation (GO:0030218)4.74686926
20bicarbonate transport (GO:0015701)4.72985510
21response to arsenic-containing substance (GO:0046685)4.64816811
22iron ion import (GO:0097286)4.43745628
23mitotic sister chromatid segregation (GO:0000070)4.35578051
24sister chromatid segregation (GO:0000819)3.97924636
25glycine transport (GO:0015816)3.96030285
26plasma lipoprotein particle assembly (GO:0034377)3.92085446
27actin filament capping (GO:0051693)3.85390201
28positive regulation of granulocyte differentiation (GO:0030854)3.82161161
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.76905806
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.75599579
31cofactor biosynthetic process (GO:0051188)3.68712151
32gas transport (GO:0015669)3.68296002
33regulation of cytokine secretion involved in immune response (GO:0002739)3.65834684
34platelet formation (GO:0030220)3.64826423
35L-alpha-amino acid transmembrane transport (GO:1902475)3.63367765
36microtubule depolymerization (GO:0007019)3.63188634
37heme transport (GO:0015886)3.63179681
38response to fungus (GO:0009620)3.54636940
39embryonic hemopoiesis (GO:0035162)3.54577750
40mitotic chromosome condensation (GO:0007076)3.51784752
41neutrophil activation involved in immune response (GO:0002283)3.48953549
42regulation of platelet aggregation (GO:0090330)3.46559363
43protein localization to chromosome, centromeric region (GO:0071459)3.42030500
44DNA damage response, signal transduction resulting in transcription (GO:0042772)3.41028840
45water-soluble vitamin biosynthetic process (GO:0042364)3.39751113
46regulation of DNA endoreduplication (GO:0032875)3.38352170
47protein-lipid complex assembly (GO:0065005)3.38100913
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36314389
49nucleosome assembly (GO:0006334)3.32612545
50granulocyte differentiation (GO:0030851)3.25231818
51detection of bacterium (GO:0016045)3.24578209
52positive regulation of chromosome segregation (GO:0051984)3.24561920
53cellular response to arsenic-containing substance (GO:0071243)3.21735273
54kinetochore organization (GO:0051383)3.18070729
55attachment of spindle microtubules to kinetochore (GO:0008608)3.17015856
56protein-cofactor linkage (GO:0018065)3.16422746
57detection of other organism (GO:0098543)3.14751898
58killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.13703864
59disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.13703864
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13602952
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.13602952
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13602952
63iron ion homeostasis (GO:0055072)3.12048565
64protein localization to kinetochore (GO:0034501)3.09818781
65DNA replication initiation (GO:0006270)3.09227840
66intracellular estrogen receptor signaling pathway (GO:0030520)3.08789854
67antibacterial humoral response (GO:0019731)3.08636059
68DNA replication-dependent nucleosome assembly (GO:0006335)3.04721698
69DNA replication-dependent nucleosome organization (GO:0034723)3.04721698
70leukocyte migration involved in inflammatory response (GO:0002523)3.04214568
71neutrophil activation (GO:0042119)3.03704885
72positive regulation of erythrocyte differentiation (GO:0045648)3.03248333
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.02572568
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02512069
75negative regulation of actin filament depolymerization (GO:0030835)3.01514230
76protoporphyrinogen IX metabolic process (GO:0046501)22.5714222
77protoporphyrinogen IX biosynthetic process (GO:0006782)21.0305567
78chromatin assembly (GO:0031497)2.99794940
79imidazole-containing compound metabolic process (GO:0052803)2.99300842
80granulocyte activation (GO:0036230)2.96606672
81defense response to Gram-positive bacterium (GO:0050830)2.93655186
82hepatocyte apoptotic process (GO:0097284)2.93314012
83DNA replication checkpoint (GO:0000076)2.91354371
84nucleosome organization (GO:0034728)2.90928344
85protein targeting to plasma membrane (GO:0072661)2.90297383
86meiotic chromosome segregation (GO:0045132)2.89500537
87regulation of exit from mitosis (GO:0007096)2.85776019
88antimicrobial humoral response (GO:0019730)2.84481135
89cell killing (GO:0001906)2.83096811
90protein-DNA complex assembly (GO:0065004)2.80840922
91import into cell (GO:0098657)2.80484298
92innate immune response in mucosa (GO:0002227)2.79473835
93positive regulation of megakaryocyte differentiation (GO:0045654)2.79410636
94cellular response to dexamethasone stimulus (GO:0071549)2.78567475
95DNA unwinding involved in DNA replication (GO:0006268)2.77812337
96N-terminal protein amino acid acetylation (GO:0006474)2.76106866
97megakaryocyte development (GO:0035855)2.74381189
98cellular response to virus (GO:0098586)2.71745515
99superoxide anion generation (GO:0042554)2.70986445
100definitive hemopoiesis (GO:0060216)2.69081380
101protein autoprocessing (GO:0016540)2.68777559
102positive regulation of bone resorption (GO:0045780)2.68118036
103positive regulation of bone remodeling (GO:0046852)2.68118036
104ovulation from ovarian follicle (GO:0001542)2.64633312
105response to dexamethasone (GO:0071548)2.63475386
106regulation of erythrocyte differentiation (GO:0045646)2.60844802
107DNA strand elongation involved in DNA replication (GO:0006271)2.59461869
108DNA topological change (GO:0006265)2.59385921
109regulation of RNA export from nucleus (GO:0046831)2.58465348
110chromatin assembly or disassembly (GO:0006333)2.58069975
1113-UTR-mediated mRNA stabilization (GO:0070935)2.55716423
112lipopolysaccharide biosynthetic process (GO:0009103)2.54436981
113protein-DNA complex subunit organization (GO:0071824)2.54081703
114hydrogen peroxide catabolic process (GO:0042744)2.53392170
115positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.52397223
116DNA strand elongation (GO:0022616)2.51334452
117regulation of granulocyte differentiation (GO:0030852)2.48712805
118response to folic acid (GO:0051593)2.48640941
119positive regulation of blood coagulation (GO:0030194)2.48446417
120positive regulation of hemostasis (GO:1900048)2.48446417
121hydrogen peroxide metabolic process (GO:0042743)2.47142746
122positive regulation of fibroblast migration (GO:0010763)2.47044481
123telomere maintenance via semi-conservative replication (GO:0032201)2.46897381
124kinetochore assembly (GO:0051382)2.45879166
125regulation of actin filament depolymerization (GO:0030834)2.44694409
126response to iron ion (GO:0010039)2.44210729
127modulation by virus of host process (GO:0019054)2.41496194
128negative regulation of actin filament polymerization (GO:0030837)2.41478776
129regulation of centriole replication (GO:0046599)2.38695897
130response to peptidoglycan (GO:0032494)2.38407913
131cellular response to thyroid hormone stimulus (GO:0097067)2.37001151
132iron coordination entity transport (GO:1901678)2.35524090
133cellular extravasation (GO:0045123)2.33915142
134CENP-A containing nucleosome assembly (GO:0034080)2.33265667
135regulation of platelet activation (GO:0010543)2.33182562
136mesodermal cell differentiation (GO:0048333)2.32941386
137positive regulation of gluconeogenesis (GO:0045722)2.32016713
138regulation of histone H3-K9 methylation (GO:0051570)2.31789002
139transition metal ion homeostasis (GO:0055076)2.31527057
140cysteine metabolic process (GO:0006534)2.31352783
141plasma lipoprotein particle organization (GO:0071827)2.31235684
142regulation of centrosome cycle (GO:0046605)2.30505814
143chromosome segregation (GO:0007059)2.30063511
144hemopoiesis (GO:0030097)2.29537771
145porphyrin-containing compound biosynthetic process (GO:0006779)14.6880327
146heme biosynthetic process (GO:0006783)14.1196023
147tetrapyrrole biosynthetic process (GO:0033014)13.1179417
148porphyrin-containing compound metabolic process (GO:0006778)11.5907866
149oxygen transport (GO:0015671)11.4937411
150heme metabolic process (GO:0042168)11.0179547
151erythrocyte maturation (GO:0043249)10.4455569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94029824
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.27049873
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse6.24813563
4GATA1_22025678_ChIP-Seq_K562_Human5.53532337
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.90320224
6GATA1_19941826_ChIP-Seq_K562_Human4.89250618
7TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse4.30239362
8* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse4.12857129
9* GATA1_19941827_ChIP-Seq_MEL_Mouse3.78829029
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75049094
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07106502
12SCL_19346495_ChIP-Seq_HPC-7_Human3.05862151
13GATA2_19941826_ChIP-Seq_K562_Human2.74019959
14GATA1_22383799_ChIP-Seq_G1ME_Mouse2.63941417
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22054769
16E2F1_21310950_ChIP-Seq_MCF-7_Human1.87647682
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84233773
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78910760
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75713714
20AR_21909140_ChIP-Seq_LNCAP_Human1.69658073
21ZNF263_19887448_ChIP-Seq_K562_Human1.68074446
22VDR_24763502_ChIP-Seq_THP-1_Human1.60587989
23SPI1_23127762_ChIP-Seq_K562_Human1.55868838
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55549843
25MYC_22102868_ChIP-Seq_BL_Human1.54565229
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45398328
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43648371
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43490829
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42320209
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41445317
31VDR_21846776_ChIP-Seq_THP-1_Human1.39801670
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35824075
33GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32157781
34NCOR1_26117541_ChIP-Seq_K562_Human1.31558355
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30749153
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.30195336
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29664820
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28404278
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27627914
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.27102194
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.26350739
42GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25450403
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.25223385
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22604823
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22470364
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21792980
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20778351
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19982024
49SPI1_23547873_ChIP-Seq_NB4_Human1.19468994
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17514906
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14468214
52MYB_26560356_Chip-Seq_TH1_Human1.13482500
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12668846
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12042407
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10902086
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10609219
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10164893
58VDR_23849224_ChIP-Seq_CD4+_Human1.09014085
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08864490
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08794009
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08675967
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08424739
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07793952
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07110375
65MYB_26560356_Chip-Seq_TH2_Human1.05267517
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02993642
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02717419
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02253960
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01917917
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01040499
71ELF1_20517297_ChIP-Seq_JURKAT_Human0.99498462
72GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98340092
73IRF8_22096565_ChIP-ChIP_GC-B_Human0.98305385
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98221562
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96509353
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96456609
77BCOR_27268052_Chip-Seq_Bcells_Human0.95427945
78MAF_26560356_Chip-Seq_TH1_Human0.92894465
79XRN2_22483619_ChIP-Seq_HELA_Human0.91270775
80EST1_17652178_ChIP-ChIP_JURKAT_Human0.91031380
81CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90404514
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90190466
83RUNX1_22412390_ChIP-Seq_EML_Mouse0.89937615
84KDM5A_27292631_Chip-Seq_BREAST_Human0.89176537
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.87244837
86SPI1_20517297_ChIP-Seq_HL60_Human0.86972450
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85453539
88GATA3_27048872_Chip-Seq_THYMUS_Human0.84938194
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.84690637
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.84613908
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84448702
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84401759
93UTX_26944678_Chip-Seq_JUKART_Human0.84363907
94PU_27001747_Chip-Seq_BMDM_Mouse0.83549773
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82625166
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82086819
97TFEB_21752829_ChIP-Seq_HELA_Human0.81746527
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81742706
99MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81267171
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81169801
101IRF8_21731497_ChIP-ChIP_J774_Mouse0.81164106
102FOXP3_21729870_ChIP-Seq_TREG_Human0.80901511
103E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80627672
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80169987
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79199826
106BCL6_27268052_Chip-Seq_Bcells_Human0.79105640
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78336975
108RUNX_20019798_ChIP-Seq_JUKART_Human0.78292360
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78058954
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77680096
111SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77275278
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76903165
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76721513
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.76552923
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76531572
116ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76437966
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76417757
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.76238359
119RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75882800
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75878768
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75285525
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.74746571
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.74693751
124DCP1A_22483619_ChIP-Seq_HELA_Human0.74198730
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.74130831
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73889800
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73589350
128KDM2B_26808549_Chip-Seq_DND41_Human0.72687169
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71843159
130TCF7_22412390_ChIP-Seq_EML_Mouse0.70870632
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70538300
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69847785
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.67782430
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.66905303
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.66729660
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66452140
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.66364158
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.66204641
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65728293
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.65060401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract3.58960348
2MP0003111_abnormal_nucleus_morphology3.40601474
3MP0010094_abnormal_chromosome_stability2.30894449
4MP0005636_abnormal_mineral_homeostasis2.27871144
5MP0005397_hematopoietic_system_phenotyp2.15106153
6MP0001545_abnormal_hematopoietic_system2.15106153
7MP0003077_abnormal_cell_cycle2.07605834
8MP0003656_abnormal_erythrocyte_physiolo12.6385986
9MP0004147_increased_porphyrin_level11.6776549
10MP0009278_abnormal_bone_marrow1.93677142
11MP0003693_abnormal_embryo_hatching1.74297491
12MP0010307_abnormal_tumor_latency1.63868200
13MP0003172_abnormal_lysosome_physiology1.57031234
14MP0008057_abnormal_DNA_replication1.48876137
15MP0005464_abnormal_platelet_physiology1.34168997
16MP0004957_abnormal_blastocyst_morpholog1.33016154
17MP0005501_abnormal_skin_physiology1.32341090
18MP0006036_abnormal_mitochondrial_physio1.29678361
19MP0008872_abnormal_physiological_respon1.28171476
20MP0008775_abnormal_heart_ventricle1.27307412
21MP0002398_abnormal_bone_marrow1.25536437
22MP0000490_abnormal_crypts_of1.22789251
23MP0005025_abnormal_response_to1.20024148
24MP0002396_abnormal_hematopoietic_system1.18700722
25MP0009785_altered_susceptibility_to1.15753157
26MP0003186_abnormal_redox_activity1.11610338
27MP0000689_abnormal_spleen_morphology1.10511984
28MP0008058_abnormal_DNA_repair1.10347806
29MP0002722_abnormal_immune_system1.10024410
30MP0000350_abnormal_cell_proliferation1.09267191
31MP0000685_abnormal_immune_system1.08773787
32MP0009931_abnormal_skin_appearance1.08093834
33MP0005451_abnormal_body_composition1.03925151
34MP0002139_abnormal_hepatobiliary_system1.02220030
35MP0008770_decreased_survivor_rate1.00901661
36MP0003436_decreased_susceptibility_to0.99654765
37MP0005377_hearing/vestibular/ear_phenot0.98904642
38MP0003878_abnormal_ear_physiology0.98904642
39MP0002166_altered_tumor_susceptibility0.97766798
40MP0003045_fibrosis0.96941387
41MP0003566_abnormal_cell_adhesion0.96294175
42MP0002419_abnormal_innate_immunity0.95889023
43MP0002429_abnormal_blood_cell0.94685093
44MP0002132_abnormal_respiratory_system0.94324992
45MP0008260_abnormal_autophagy0.91312881
46MP0000313_abnormal_cell_death0.90294424
47MP0004185_abnormal_adipocyte_glucose0.88207178
48MP0004130_abnormal_muscle_cell0.86883228
49MP0000749_muscle_degeneration0.86369502
50MP0002019_abnormal_tumor_incidence0.86214310
51MP0003724_increased_susceptibility_to0.85926562
52MP0005058_abnormal_lysosome_morphology0.85773094
53MP0009697_abnormal_copulation0.80886751
54MP0009765_abnormal_xenobiotic_induced0.79553911
55MP0000609_abnormal_liver_physiology0.79020235
56MP0001529_abnormal_vocalization0.78825090
57MP0000465_gastrointestinal_hemorrhage0.78773059
58MP0005076_abnormal_cell_differentiation0.76579189
59MP0001835_abnormal_antigen_presentation0.75492029
60MP0001730_embryonic_growth_arrest0.73929381
61MP0009333_abnormal_splenocyte_physiolog0.73255910
62MP0003879_abnormal_hair_cell0.73091359
63MP0008995_early_reproductive_senescence0.72382755
64MP0004808_abnormal_hematopoietic_stem0.71493011
65MP0002080_prenatal_lethality0.70736331
66MP0004947_skin_inflammation0.70638852
67MP0002420_abnormal_adaptive_immunity0.70265073
68MP0006054_spinal_hemorrhage0.69978596
69MP0005000_abnormal_immune_tolerance0.69778679
70MP0002736_abnormal_nociception_after0.69366736
71MP0009764_decreased_sensitivity_to0.69239997
72MP0002086_abnormal_extraembryonic_tissu0.68523916
73MP0001819_abnormal_immune_cell0.68439574
74MP0005085_abnormal_gallbladder_physiolo0.67394743
75MP0000343_altered_response_to0.67311661
76MP0008004_abnormal_stomach_pH0.67028004
77MP0003763_abnormal_thymus_physiology0.66140829
78MP0002877_abnormal_melanocyte_morpholog0.65200289
79MP0000015_abnormal_ear_pigmentation0.64441374
80MP0010771_integument_phenotype0.63232443
81MP0003806_abnormal_nucleotide_metabolis0.62197357
82MP0000703_abnormal_thymus_morphology0.61710249
83MP0001663_abnormal_digestive_system0.60184753
84MP0001697_abnormal_embryo_size0.59426645
85MP0003866_abnormal_defecation0.59117246
86MP0000598_abnormal_liver_morphology0.58985934
87MP0001851_eye_inflammation0.58232598
88MP0009763_increased_sensitivity_to0.57031409
89MP0005621_abnormal_cell_physiology0.56402283
90MP0008932_abnormal_embryonic_tissue0.56077748
91MP0005075_abnormal_melanosome_morpholog0.55971628
92MP0001915_intracranial_hemorrhage0.55926916
93MP0005365_abnormal_bile_salt0.55683008
94MP0003300_gastrointestinal_ulcer0.54794639
95MP0009053_abnormal_anal_canal0.54469480
96MP0003123_paternal_imprinting0.54122290
97MP0001845_abnormal_inflammatory_respons0.53242179
98MP0005360_urolithiasis0.52792402
99MP0001790_abnormal_immune_system0.52764672
100MP0005387_immune_system_phenotype0.52764672
101MP0002009_preneoplasia0.52750974
102MP0002735_abnormal_chemical_nociception0.52450669
103MP0003191_abnormal_cellular_cholesterol0.52380454
104MP0001664_abnormal_digestion0.52290506
105MP0005384_cellular_phenotype0.52053395
106MP0009643_abnormal_urine_homeostasis0.51898703
107MP0004197_abnormal_fetal_growth/weight/0.51738928
108MP0008877_abnormal_DNA_methylation0.51431987
109MP0005380_embryogenesis_phenotype0.50541244
110MP0001672_abnormal_embryogenesis/_devel0.50541244
111MP0001800_abnormal_humoral_immune0.50323335
112MP0003453_abnormal_keratinocyte_physiol0.49837964
113MP0005671_abnormal_response_to0.48914137
114MP0010155_abnormal_intestine_physiology0.48781398
115MP0002452_abnormal_antigen_presenting0.48355728
116MP0002723_abnormal_immune_serum0.46925885
117MP0002136_abnormal_kidney_physiology0.46364216
118MP0002405_respiratory_system_inflammati0.46002813
119MP0003984_embryonic_growth_retardation0.45882830
120MP0004264_abnormal_extraembryonic_tissu0.45653913
121MP0003705_abnormal_hypodermis_morpholog0.45374635
122MP0004215_abnormal_myocardial_fiber0.43887507
123MP0002138_abnormal_hepatobiliary_system0.43878790
124MP0008007_abnormal_cellular_replicative0.43871625
125MP0002088_abnormal_embryonic_growth/wei0.43675156
126MP0002095_abnormal_skin_pigmentation0.43059367
127MP0001764_abnormal_homeostasis0.42349007
128MP0001191_abnormal_skin_condition0.41901537
129MP0009672_abnormal_birth_weight0.40941317
130MP0002332_abnormal_exercise_endurance0.40936877
131MP0001756_abnormal_urination0.39388148
132MP0003303_peritoneal_inflammation0.39347522
133MP0010352_gastrointestinal_tract_polyps0.38001033
134MP0000716_abnormal_immune_system0.37799668
135MP0001243_abnormal_dermal_layer0.37779864
136MP0000358_abnormal_cell_content/0.36661352
137MP0005319_abnormal_enzyme/_coenzyme0.36371209
138MP0010329_abnormal_lipoprotein_level0.34733407
139MP0000266_abnormal_heart_morphology0.34560380
140MP0000858_altered_metastatic_potential0.34244648
141MP0003786_premature_aging0.32571138
142MP0009703_decreased_birth_body0.31143673
143MP0001784_abnormal_fluid_regulation0.30837121
144MP0005584_abnormal_enzyme/coenzyme_acti0.30723749
145MP0001919_abnormal_reproductive_system0.30461555

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)9.91065685
2Reticulocytosis (HP:0001923)8.73547201
3Cholelithiasis (HP:0001081)7.39608052
4Diaphragmatic weakness (HP:0009113)6.98415434
5Paralysis (HP:0003470)6.77979144
6Abnormal gallbladder morphology (HP:0012437)6.70182202
7Abnormality of reticulocytes (HP:0004312)5.88783072
8Hyperbilirubinemia (HP:0002904)5.73288624
9Abnormal hemoglobin (HP:0011902)5.72414314
10Osteomalacia (HP:0002749)5.61436412
11Insomnia (HP:0100785)5.42030192
12Hypochromic anemia (HP:0001931)5.38256862
13Microcytic anemia (HP:0001935)4.77783149
14Abnormality of the gallbladder (HP:0005264)4.65692268
15Ileus (HP:0002595)4.43658797
16Cutaneous photosensitivity (HP:0000992)4.42414730
17Cholecystitis (HP:0001082)4.37394850
18Abnormal gallbladder physiology (HP:0012438)4.37394850
19Toxemia of pregnancy (HP:0100603)3.82416987
20Polycythemia (HP:0001901)3.56464094
21Abnormal number of erythroid precursors (HP:0012131)3.45517098
22Hepatocellular carcinoma (HP:0001402)3.34719078
23Abnormality of cells of the erythroid lineage (HP:0012130)3.20478906
24Menorrhagia (HP:0000132)3.07884644
25Hyponatremia (HP:0002902)3.06087873
26Gingival bleeding (HP:0000225)2.83373941
27Abnormality of sodium homeostasis (HP:0010931)2.80742743
28Increased serum ferritin (HP:0003281)2.80183187
29Birth length less than 3rd percentile (HP:0003561)2.79521615
30Nausea (HP:0002018)2.68003596
31Gastrointestinal infarctions (HP:0005244)2.67241393
32Abnormality of iron homeostasis (HP:0011031)2.59281335
33Urticaria (HP:0001025)2.58343752
34Petechiae (HP:0000967)2.56334921
35Confusion (HP:0001289)2.54296723
36Onycholysis (HP:0001806)2.48146975
37Abnormality of transition element cation homeostasis (HP:0011030)2.34420092
38Pustule (HP:0200039)2.31167622
39Cerebral palsy (HP:0100021)2.30331608
40Thrombophlebitis (HP:0004418)2.24037710
41Renal tubular acidosis (HP:0001947)2.23691566
42Generalized hyperpigmentation (HP:0007440)2.21975314
43Prolonged bleeding time (HP:0003010)2.18147666
44Global brain atrophy (HP:0002283)2.17925148
45Pathologic fracture (HP:0002756)2.16339807
46Short middle phalanx of the 5th finger (HP:0004220)2.15394256
47Spontaneous hematomas (HP:0007420)2.14074213
48Hypertensive crisis (HP:0100735)2.13121524
49Delusions (HP:0000746)2.12292502
50Macrocytic anemia (HP:0001972)2.02527646
51Nonimmune hydrops fetalis (HP:0001790)2.01094535
52Abnormality of the heme biosynthetic pathway (HP:0010472)15.2748979
53Poikilocytosis (HP:0004447)14.1687566
54Hypochromic microcytic anemia (HP:0004840)11.0478039
55Hyperlipoproteinemia (HP:0010980)1.96605130
56Osteomyelitis (HP:0002754)1.92269991
57Lower limb hyperreflexia (HP:0002395)1.85097429
58Orthostatic hypotension (HP:0001278)1.84017002
59Eczematoid dermatitis (HP:0000976)1.82608984
60Paresthesia (HP:0003401)1.82524248
61Childhood onset (HP:0011463)1.78880708
62Recurrent abscess formation (HP:0002722)1.76332332
63Rickets (HP:0002748)1.71917666
64Epistaxis (HP:0000421)1.71903934
65Visual hallucinations (HP:0002367)1.71893976
66Recurrent bacterial skin infections (HP:0005406)1.71774581
67Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71381324
68Autoimmune hemolytic anemia (HP:0001890)1.70253385
69Depression (HP:0000716)1.68507310
70Bruising susceptibility (HP:0000978)1.67302019
71Purpura (HP:0000979)1.66996129
72Hypoparathyroidism (HP:0000829)1.64517066
73Chronic obstructive pulmonary disease (HP:0006510)1.64428577
74Obstructive lung disease (HP:0006536)1.64428577
75Recurrent gram-negative bacterial infections (HP:0005420)1.62218695
76Neoplasm of the liver (HP:0002896)1.56457288
77Abnormal blistering of the skin (HP:0008066)1.55374608
78Pallor (HP:0000980)1.52118538
79Splenomegaly (HP:0001744)1.51863703
80Anorexia (HP:0002039)1.50886338
81Keratoconjunctivitis sicca (HP:0001097)1.50536301
82Abnormality of macrophages (HP:0004311)1.49728824
83Hepatosplenomegaly (HP:0001433)1.49052882
84Basal cell carcinoma (HP:0002671)1.47448225
85Systemic lupus erythematosus (HP:0002725)1.47062423
86Metaphyseal cupping (HP:0003021)1.43754838
87Cafe-au-lait spot (HP:0000957)1.43476787
88Skin rash (HP:0000988)1.41819383
89Hypertriglyceridemia (HP:0002155)1.41814009
90Thin skin (HP:0000963)1.41771999
91Encephalitis (HP:0002383)1.40888457
92Cellulitis (HP:0100658)1.40231806
93Aplasia/Hypoplasia of the earlobes (HP:0009906)1.39880940
94Broad palm (HP:0001169)1.38819564
95Deep venous thrombosis (HP:0002625)1.37582287
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.36886698
97Gastrointestinal dysmotility (HP:0002579)1.35751689
98Seborrheic dermatitis (HP:0001051)1.35503111
99Thyroid carcinoma (HP:0002890)1.34335361
100Papillary thyroid carcinoma (HP:0002895)1.34266735
101Autoimmune thrombocytopenia (HP:0001973)1.33818080
102Metabolic acidosis (HP:0001942)1.33639076
103Gingivitis (HP:0000230)1.33144365
104Keratoconjunctivitis (HP:0001096)1.32853443
105Prenatal maternal abnormality (HP:0002686)1.32031794
106Anxiety (HP:0000739)1.31206752
107Peripheral hypomyelination (HP:0007182)1.30984277
108Absent epiphyses (HP:0010577)1.30915170
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30915170
110Increased mean platelet volume (HP:0011877)1.30877058
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.30669387
112Joint hemorrhage (HP:0005261)1.30617633
113Abnormality of the common coagulation pathway (HP:0010990)1.30368080
114Cortical visual impairment (HP:0100704)1.30046354
115Abnormal platelet function (HP:0011869)1.29622266
116Impaired platelet aggregation (HP:0003540)1.29622266
117Arthralgia (HP:0002829)1.29243384
118Abnormal platelet volume (HP:0011876)1.29059399
119Conjunctival telangiectasia (HP:0000524)1.28933707
120Breast hypoplasia (HP:0003187)1.26670248
121Papilloma (HP:0012740)1.26436357
122Verrucae (HP:0200043)1.26436357
123Ventricular fibrillation (HP:0001663)1.26334579
124Recurrent viral infections (HP:0004429)1.26198497
125High pitched voice (HP:0001620)1.24332338
126Abnormality of the fingertips (HP:0001211)1.24327874
127Duodenal stenosis (HP:0100867)1.22972577
128Small intestinal stenosis (HP:0012848)1.22972577
129Abnormality of dental color (HP:0011073)1.22723040
130Hypopigmented skin patches (HP:0001053)1.22376766
131Progressive microcephaly (HP:0000253)1.21449428
132Erythema (HP:0010783)1.20114723
133Pancreatic islet-cell hyperplasia (HP:0004510)1.19992097
134Chromsome breakage (HP:0040012)1.19608601
135Short 5th finger (HP:0009237)1.19580427
136Renal tubular dysfunction (HP:0000124)1.19353538
137Cortical dysplasia (HP:0002539)1.17012489
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.16586996
139Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.16135983
140Hemorrhage of the eye (HP:0011885)1.12562086
141Fragile skin (HP:0001030)1.09913364
142Abdominal pain (HP:0002027)1.07226232
143Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.06591065
144Psychosis (HP:0000709)1.06471287
145Prostate neoplasm (HP:0100787)1.05780061
146Impulsivity (HP:0100710)1.04731048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK18.00290488
2PRPF4B4.76514195
3TLK14.46010458
4STK43.52359890
5CDC73.46376434
6CDK122.95947588
7BRSK12.90148816
8ZAK2.61308814
9RIPK42.29111719
10STK102.18624098
11BUB12.14298790
12NME22.10287976
13MAP3K32.06800874
14NEK22.05717657
15VRK12.04368654
16DYRK31.98778520
17EEF2K1.85793718
18FGR1.85445947
19PIM11.78907387
20WNK11.75138624
21TRPM71.59856857
22AURKB1.58798863
23MAPK111.57924759
24GRK61.56401070
25MAP3K81.56088634
26AURKA1.47929018
27RPS6KA51.47738299
28BRSK21.41884834
29MAPKAPK31.36495131
30PBK1.34176985
31MAP3K51.31203687
32CHEK21.29049753
33SCYL21.28785064
34MAP3K101.26827646
35TEC1.23414055
36MAP3K111.22003021
37TTK1.21265567
38BTK1.18566743
39CDK61.16380241
40CDK41.13936080
41SYK1.11646242
42GRK51.10521887
43WEE11.08954768
44PLK11.06505553
45MELK1.05039541
46ZAP701.04922008
47BRD41.01169525
48TAOK30.99177949
49TAOK10.93722710
50NEK10.93448406
51TNK20.93258931
52ERBB20.92891678
53CHEK10.91123075
54MAP3K10.90810409
55SGK20.89865728
56MAP3K60.88779079
57CDK90.86360997
58HIPK20.85649882
59PRKAA10.83111892
60CDC42BPA0.82588844
61ATM0.79926330
62JAK20.78110073
63MAPKAPK50.77860806
64RPS6KB20.77331884
65TGFBR20.77024943
66RPS6KC10.75158708
67RPS6KL10.75158708
68ATR0.69924422
69ABL20.69724703
70SMG10.68280634
71FES0.68109121
72TRIB30.66191903
73STK30.65317510
74GRK70.64506918
75PLK30.63825487
76BMX0.61756843
77RPS6KA60.61398772
78DYRK1B0.61058476
79ERN10.60083115
80STK110.59900436
81PLK20.59786149
82MAP2K30.59332106
83DAPK20.59098526
84PKN20.58152269
85MAPKAPK20.56956553
86HCK0.56828491
87LYN0.55231277
88MAP4K10.53781195
89BLK0.53660056
90MAP2K40.52976095
91IRAK40.51861355
92MAP2K10.51667853
93CDK10.50813721
94CDK20.50706799
95EIF2AK20.50688364
96CAMK1D0.50250007
97CSNK1D0.49275355
98KSR10.48969328
99FGFR30.48913062
100DYRK1A0.48839552
101SGK2230.45543572
102SGK4940.45543572
103ICK0.45411496
104TYK20.44384225
105SGK10.43840201
106CAMK1G0.43156230
107CLK10.42378391
108SGK30.41290392
109PLK40.41092603
110YES10.40914827
111RET0.40510605
112CDK150.39570996
113PDPK10.39261709
114MAP2K20.37624593
115CDK11A0.37418656
116PTK2B0.37349593
117CDK70.36783863
118PRKACG0.36701481
119MST40.36667704
120FLT30.35989770
121IKBKE0.35831475
122ITK0.34697922
123CSK0.34001845
124PRKDC0.33421449
125BRAF0.33325453
126CDK180.32805732
127PIK3CG0.32210359
128JAK30.31677527
129PRKCQ0.31420342
130AKT20.31196376
131CDK140.30367349
132TAOK20.30200383
133PDK10.29382923
134CSNK2A10.29227463
135LRRK20.28615860
136AKT10.28210091
137PRKAA20.27964641
138STK240.27749879
139MAPK140.27022708
140MARK30.26426003
141PIK3CA0.25542537
142MOS0.24582475
143IKBKB0.24363104
144MAPK120.24261709
145RPS6KA10.23418855
146SRPK10.22381990
147RPS6KA30.20946305

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008609.70775356
2Vitamin B6 metabolism_Homo sapiens_hsa007506.09066863
3Systemic lupus erythematosus_Homo sapiens_hsa053225.88416924
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.40891568
5DNA replication_Homo sapiens_hsa030303.18264162
6Alcoholism_Homo sapiens_hsa050343.16982774
7Cell cycle_Homo sapiens_hsa041102.64509753
8African trypanosomiasis_Homo sapiens_hsa051432.45206001
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98580180
10ABC transporters_Homo sapiens_hsa020101.68354339
11Mismatch repair_Homo sapiens_hsa034301.66759815
12Viral carcinogenesis_Homo sapiens_hsa052031.60834465
13Sulfur relay system_Homo sapiens_hsa041221.54892840
14Hematopoietic cell lineage_Homo sapiens_hsa046401.53416731
15Malaria_Homo sapiens_hsa051441.51771004
16One carbon pool by folate_Homo sapiens_hsa006701.45587995
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41923403
18Nucleotide excision repair_Homo sapiens_hsa034201.40338544
19Collecting duct acid secretion_Homo sapiens_hsa049661.32179373
20p53 signaling pathway_Homo sapiens_hsa041151.29666278
21Bladder cancer_Homo sapiens_hsa052191.29297011
22Base excision repair_Homo sapiens_hsa034101.28133073
23Homologous recombination_Homo sapiens_hsa034401.19854770
24Fanconi anemia pathway_Homo sapiens_hsa034601.17235513
25Asthma_Homo sapiens_hsa053101.13052330
26Acute myeloid leukemia_Homo sapiens_hsa052211.13038086
27Fatty acid biosynthesis_Homo sapiens_hsa000611.12239554
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.07795854
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05742851
30B cell receptor signaling pathway_Homo sapiens_hsa046621.03750653
31Selenocompound metabolism_Homo sapiens_hsa004501.03200456
32Non-small cell lung cancer_Homo sapiens_hsa052231.01621435
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99392294
34Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97348781
35Jak-STAT signaling pathway_Homo sapiens_hsa046300.96633253
36Renal cell carcinoma_Homo sapiens_hsa052110.92425196
37HIF-1 signaling pathway_Homo sapiens_hsa040660.92178025
38Osteoclast differentiation_Homo sapiens_hsa043800.91394664
39Glutathione metabolism_Homo sapiens_hsa004800.88392267
40Ribosome_Homo sapiens_hsa030100.85384941
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85285883
42RNA transport_Homo sapiens_hsa030130.83461558
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82450390
44Spliceosome_Homo sapiens_hsa030400.81989101
45Chronic myeloid leukemia_Homo sapiens_hsa052200.80263060
46Apoptosis_Homo sapiens_hsa042100.80160562
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79482721
48Oocyte meiosis_Homo sapiens_hsa041140.78453054
49Endometrial cancer_Homo sapiens_hsa052130.75648108
50Small cell lung cancer_Homo sapiens_hsa052220.72630074
51Leishmaniasis_Homo sapiens_hsa051400.70789190
52Glycerolipid metabolism_Homo sapiens_hsa005610.69018915
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68480309
54Chemokine signaling pathway_Homo sapiens_hsa040620.68252156
55Type II diabetes mellitus_Homo sapiens_hsa049300.67747215
56Herpes simplex infection_Homo sapiens_hsa051680.67654891
57Pyrimidine metabolism_Homo sapiens_hsa002400.67526956
58Starch and sucrose metabolism_Homo sapiens_hsa005000.67145960
59Choline metabolism in cancer_Homo sapiens_hsa052310.66437509
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66044765
61Non-homologous end-joining_Homo sapiens_hsa034500.65139832
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62612566
63mTOR signaling pathway_Homo sapiens_hsa041500.62102870
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62100507
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61635523
66Tuberculosis_Homo sapiens_hsa051520.61340769
67PPAR signaling pathway_Homo sapiens_hsa033200.60731675
68Inositol phosphate metabolism_Homo sapiens_hsa005620.60513492
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60265861
70Nitrogen metabolism_Homo sapiens_hsa009100.56688505
71mRNA surveillance pathway_Homo sapiens_hsa030150.56396986
72Complement and coagulation cascades_Homo sapiens_hsa046100.55303103
73Proteasome_Homo sapiens_hsa030500.54414813
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54291820
75Pyruvate metabolism_Homo sapiens_hsa006200.50574292
76T cell receptor signaling pathway_Homo sapiens_hsa046600.50458881
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50095432
78Fructose and mannose metabolism_Homo sapiens_hsa000510.49465427
79Dorso-ventral axis formation_Homo sapiens_hsa043200.47707418
80Pancreatic cancer_Homo sapiens_hsa052120.47636416
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.46314916
82AMPK signaling pathway_Homo sapiens_hsa041520.46199190
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.46190664
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.45354624
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45215476
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43946432
87Hepatitis B_Homo sapiens_hsa051610.43663974
88Phagosome_Homo sapiens_hsa041450.43248831
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43084221
90Prolactin signaling pathway_Homo sapiens_hsa049170.42072456
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41827184
92Insulin signaling pathway_Homo sapiens_hsa049100.41213135
93Notch signaling pathway_Homo sapiens_hsa043300.40097322
94Glioma_Homo sapiens_hsa052140.38793921
95TNF signaling pathway_Homo sapiens_hsa046680.38041112
96Folate biosynthesis_Homo sapiens_hsa007900.37385294
97Prostate cancer_Homo sapiens_hsa052150.36666185
98Endocytosis_Homo sapiens_hsa041440.36294852
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36258176
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35499375
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.34738398
102Renin-angiotensin system_Homo sapiens_hsa046140.34470108
103MicroRNAs in cancer_Homo sapiens_hsa052060.33658002
104Toxoplasmosis_Homo sapiens_hsa051450.33304316
105Arachidonic acid metabolism_Homo sapiens_hsa005900.33185120
106RNA degradation_Homo sapiens_hsa030180.32395588
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32300444
108Lysine degradation_Homo sapiens_hsa003100.31810271
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31792316
110Thyroid cancer_Homo sapiens_hsa052160.31639125
111VEGF signaling pathway_Homo sapiens_hsa043700.31588119
112HTLV-I infection_Homo sapiens_hsa051660.31566149
113FoxO signaling pathway_Homo sapiens_hsa040680.30408636
114Measles_Homo sapiens_hsa051620.29925938
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29056143
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.28621508
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28507454
118Pentose phosphate pathway_Homo sapiens_hsa000300.27343487
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27241327
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.27089576
121Biosynthesis of amino acids_Homo sapiens_hsa012300.25173917
122Purine metabolism_Homo sapiens_hsa002300.23395746
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.22912610
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22452889
125Metabolic pathways_Homo sapiens_hsa011000.22287392
126Epstein-Barr virus infection_Homo sapiens_hsa051690.21472954
127Parkinsons disease_Homo sapiens_hsa050120.21111799
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19680506
129Bile secretion_Homo sapiens_hsa049760.17926266
130Carbon metabolism_Homo sapiens_hsa012000.17591782
131Caffeine metabolism_Homo sapiens_hsa002320.16851950
132Melanoma_Homo sapiens_hsa052180.15669237
133Fat digestion and absorption_Homo sapiens_hsa049750.13702081
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.13326429
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12902581
136Hepatitis C_Homo sapiens_hsa051600.11666622
137Huntingtons disease_Homo sapiens_hsa050160.10983850
138Influenza A_Homo sapiens_hsa051640.10857431
139Platelet activation_Homo sapiens_hsa046110.10651458
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.10122241
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09936701
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09905741
143beta-Alanine metabolism_Homo sapiens_hsa004100.08641996
144Regulation of autophagy_Homo sapiens_hsa041400.06894120
145Staphylococcus aureus infection_Homo sapiens_hsa051500.04702842
146Antigen processing and presentation_Homo sapiens_hsa046120.03840855
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.03803960
148Tryptophan metabolism_Homo sapiens_hsa003800.03547752
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.02655756
150Insulin resistance_Homo sapiens_hsa049310.02162653
151Gap junction_Homo sapiens_hsa045400.01264023
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.00926461

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