TRIM11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.77537936
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.77537936
3positive regulation of gamma-delta T cell activation (GO:0046645)5.44188701
4antigen processing and presentation of endogenous antigen (GO:0019883)5.31841125
5regulation of gamma-delta T cell differentiation (GO:0045586)4.93487420
6modulation by virus of host process (GO:0019054)4.82777211
7regulation of gamma-delta T cell activation (GO:0046643)4.39819560
8regulation of chromatin binding (GO:0035561)4.28174563
9modulation by symbiont of host cellular process (GO:0044068)4.14082851
10positive thymic T cell selection (GO:0045059)4.06730937
11antigen processing and presentation via MHC class Ib (GO:0002475)4.02731568
12poly(A)+ mRNA export from nucleus (GO:0016973)3.99076202
13positive regulation of B cell differentiation (GO:0045579)3.86853814
14macrophage activation involved in immune response (GO:0002281)3.84614845
15chromosome condensation (GO:0030261)3.83139040
16B cell receptor signaling pathway (GO:0050853)3.79114625
17DNA packaging (GO:0006323)3.57077369
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53755999
19regulation of B cell differentiation (GO:0045577)3.48611181
20positive regulation of histone deacetylation (GO:0031065)3.48446029
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41080300
22spliceosomal tri-snRNP complex assembly (GO:0000244)3.34886898
23intracellular estrogen receptor signaling pathway (GO:0030520)3.32049226
24thymic T cell selection (GO:0045061)3.26440975
25negative T cell selection (GO:0043383)3.22683318
26T cell selection (GO:0045058)3.18800297
27negative thymic T cell selection (GO:0045060)3.17153716
28pentose-phosphate shunt (GO:0006098)3.16779006
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.11588858
30negative regulation of phagocytosis (GO:0050765)3.10315668
31activation of Rac GTPase activity (GO:0032863)3.08481699
32histone H3-K36 demethylation (GO:0070544)3.08250461
33regulation of B cell receptor signaling pathway (GO:0050855)3.08173430
34leukocyte aggregation (GO:0070486)3.08066052
35positive T cell selection (GO:0043368)3.05284729
36apoptotic process involved in morphogenesis (GO:0060561)3.01880375
37natural killer cell differentiation (GO:0001779)3.01666703
38response to peptidoglycan (GO:0032494)2.98848852
39positive regulation of Cdc42 GTPase activity (GO:0043089)2.96870196
40positive regulation of protein deacetylation (GO:0090312)2.96149267
41G1 DNA damage checkpoint (GO:0044783)2.94524026
42snRNA metabolic process (GO:0016073)2.92047089
43CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90687032
44regulation of RNA export from nucleus (GO:0046831)2.90420196
45NIK/NF-kappaB signaling (GO:0038061)2.89462660
46nuclear pore organization (GO:0006999)2.89205992
47response to muramyl dipeptide (GO:0032495)2.88239854
48regulation of interleukin-12 biosynthetic process (GO:0045075)2.87905169
49mitotic G1/S transition checkpoint (GO:0044819)2.87018144
50regulation of apoptotic process involved in morphogenesis (GO:1902337)2.86438519
51mitotic G1 DNA damage checkpoint (GO:0031571)2.82926902
52negative regulation of stress fiber assembly (GO:0051497)2.81039722
53nuclear pore complex assembly (GO:0051292)2.80289593
54neutrophil activation involved in immune response (GO:0002283)2.79699708
55dosage compensation (GO:0007549)2.79507381
56mannose metabolic process (GO:0006013)2.78520908
57GDP-mannose metabolic process (GO:0019673)2.75988478
58regulation of interferon-beta biosynthetic process (GO:0045357)2.75734581
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73592503
60lymph vessel development (GO:0001945)2.72791736
61immunoglobulin mediated immune response (GO:0016064)2.72421146
62chromatin silencing (GO:0006342)2.72265473
63NADPH regeneration (GO:0006740)2.71124882
64regulation of nucleobase-containing compound transport (GO:0032239)2.69501528
65cellular hyperosmotic response (GO:0071474)2.69050854
66regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67810232
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67465399
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67465399
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.67465399
70modulation by symbiont of host immune response (GO:0052553)2.67465399
71positive regulation by symbiont of host defense response (GO:0052509)2.67465399
72modulation by symbiont of host defense response (GO:0052031)2.67465399
73regulation of ARF GTPase activity (GO:0032312)2.65059977
74embryonic process involved in female pregnancy (GO:0060136)2.64458065
75negative regulation of erythrocyte differentiation (GO:0045647)2.64269937
76histone H3-K4 trimethylation (GO:0080182)2.63151471
77positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.62963454
78regulation of NFAT protein import into nucleus (GO:0051532)2.61931682
79regulation of histone H3-K9 methylation (GO:0051570)2.60026523
80JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59426171
81histone H3-K4 methylation (GO:0051568)2.58625855
82trophectodermal cell differentiation (GO:0001829)2.57114975
83histone H3-K9 modification (GO:0061647)2.56899810
84negative regulation of histone methylation (GO:0031061)2.56834369
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56818184
86antigen receptor-mediated signaling pathway (GO:0050851)2.55995277
87histone lysine demethylation (GO:0070076)2.55788193
88histone demethylation (GO:0016577)2.54266316
893-UTR-mediated mRNA stabilization (GO:0070935)2.53685145
90* negative regulation of viral release from host cell (GO:1902187)2.51899501
91cellular response to virus (GO:0098586)2.51786401
92regulation of histone H3-K4 methylation (GO:0051569)2.51728377
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.48810546
94type I interferon signaling pathway (GO:0060337)2.48613904
95cellular response to type I interferon (GO:0071357)2.48613904
96atrioventricular valve morphogenesis (GO:0003181)2.47854699
97regulation of superoxide anion generation (GO:0032928)2.47803439
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47437864
99negative regulation of cell killing (GO:0031342)2.47437864
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46392514
101response to interleukin-15 (GO:0070672)2.45724368
102positive regulation of lamellipodium assembly (GO:0010592)2.45607584
103myeloid cell activation involved in immune response (GO:0002275)2.45056503
104histone H3-K9 demethylation (GO:0033169)2.43706325
105disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.43067023
106killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.43067023
107positive regulation of protein homooligomerization (GO:0032464)2.42396190
108regulation of integrin activation (GO:0033623)2.41261482
109negative regulation of cell size (GO:0045792)2.41122708
110T cell lineage commitment (GO:0002360)2.40608267
111modulation by virus of host morphology or physiology (GO:0019048)2.40121910
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.40067216
113T cell homeostasis (GO:0043029)2.39210431
114hepatocyte apoptotic process (GO:0097284)2.39189104
115pinocytosis (GO:0006907)2.39105832
116folic acid-containing compound biosynthetic process (GO:0009396)2.38784004
117morphogenesis of an endothelium (GO:0003159)2.38721598
118endothelial tube morphogenesis (GO:0061154)2.38721598
119positive regulation of T cell mediated cytotoxicity (GO:0001916)2.37151951
120regulation of cholesterol homeostasis (GO:2000188)2.34863228
121V(D)J recombination (GO:0033151)2.31934790
122mitotic chromosome condensation (GO:0007076)2.31571408
123alpha-linolenic acid metabolic process (GO:0036109)2.30916569
124histone H3-K9 methylation (GO:0051567)2.30523453
125regulation of fatty acid beta-oxidation (GO:0031998)2.29509619
126lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27690860
127regulation of histone methylation (GO:0031060)2.27288900
128regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.27270266
129Peyers patch development (GO:0048541)2.27174924
130mucosal-associated lymphoid tissue development (GO:0048537)2.27174924
131protein demethylation (GO:0006482)2.26886509
132protein dealkylation (GO:0008214)2.26886509
133defense response to fungus (GO:0050832)2.26008787
134positive regulation of triglyceride biosynthetic process (GO:0010867)2.25851158
135T cell apoptotic process (GO:0070231)2.25712761
136regulation of necroptotic process (GO:0060544)2.24691439
137lymphocyte homeostasis (GO:0002260)2.24666329
138regulation of histone H3-K27 methylation (GO:0061085)2.24096686
139response to laminar fluid shear stress (GO:0034616)2.21925411
140negative regulation of granulocyte differentiation (GO:0030853)2.21468065
141negative regulation of innate immune response (GO:0045824)2.21456797
142regulation of response to interferon-gamma (GO:0060330)2.19866730
143T cell receptor signaling pathway (GO:0050852)2.19437831
144B cell mediated immunity (GO:0019724)2.19064443
145positive regulation of interferon-alpha production (GO:0032727)2.18952135
146regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.18359462
147positive regulation of lamellipodium organization (GO:1902745)2.18310061
148RNA stabilization (GO:0043489)2.17348685
149mRNA stabilization (GO:0048255)2.17348685
150T cell costimulation (GO:0031295)2.16550630
151regulation of translational fidelity (GO:0006450)2.15914661
152regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.14279880
153regulation of monocyte differentiation (GO:0045655)2.13156126
154negative regulation of necroptotic process (GO:0060546)2.11579440
155valine metabolic process (GO:0006573)2.11035514
156lymphocyte costimulation (GO:0031294)2.09797753
157negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.09460842
158regulation of alpha-beta T cell proliferation (GO:0046640)2.08961172
159cellular response to zinc ion (GO:0071294)2.08842464
160response to type I interferon (GO:0034340)2.08540335
161negative regulation of gene expression, epigenetic (GO:0045814)2.06644587
162positive regulation of gene expression, epigenetic (GO:0045815)2.06441870
163protein-DNA complex disassembly (GO:0032986)2.06374274
164nucleosome disassembly (GO:0006337)2.06374274
165regulation of granulocyte differentiation (GO:0030852)2.06079982
166DNA unwinding involved in DNA replication (GO:0006268)2.05890678
167immune response-activating cell surface receptor signaling pathway (GO:0002429)2.03902118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.69635971
2MYC_22102868_ChIP-Seq_BL_Human3.66186288
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.99135914
4VDR_21846776_ChIP-Seq_THP-1_Human2.96437714
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.86780379
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50270135
7* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.43653411
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.41108556
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40627611
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33434138
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23260208
12MAF_26560356_Chip-Seq_TH1_Human2.22926664
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22505449
14TCF7_22412390_ChIP-Seq_EML_Mouse2.22050166
15UTX_26944678_Chip-Seq_JUKART_Human2.15038926
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08320411
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07447992
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03541277
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96739588
20MYB_26560356_Chip-Seq_TH2_Human1.95690860
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94327519
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.94131936
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94126171
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92428706
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92078023
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92007744
27* MYB_26560356_Chip-Seq_TH1_Human1.84407609
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82370780
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82171874
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82014166
31SCL_19346495_ChIP-Seq_HPC-7_Human1.78605771
32VDR_24763502_ChIP-Seq_THP-1_Human1.77062508
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75595923
34CIITA_25753668_ChIP-Seq_RAJI_Human1.75113661
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73372426
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73039476
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.70727468
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69993470
39* KDM2B_26808549_Chip-Seq_DND41_Human1.68391620
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68163876
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67985788
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.66008745
43RUNX_20019798_ChIP-Seq_JUKART_Human1.63801521
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.63772948
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.61049857
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60063693
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59943861
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54756499
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54406957
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.54350382
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52983706
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51614040
53KDM2B_26808549_Chip-Seq_K562_Human1.51545124
54SMC4_20622854_ChIP-Seq_HELA_Human1.51486740
55MAF_26560356_Chip-Seq_TH2_Human1.50060824
56SPI1_23547873_ChIP-Seq_NB4_Human1.47792770
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47244951
58XRN2_22483619_ChIP-Seq_HELA_Human1.47078034
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46560821
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46548272
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44238033
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.44106293
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43775809
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43175477
65CREB1_26743006_Chip-Seq_LNCaP_Human1.42233486
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35059311
67ATF3_27146783_Chip-Seq_COLON_Human1.32616149
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32238348
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31976920
70PHF8_20622854_ChIP-Seq_HELA_Human1.31007808
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30822250
72* LXR_22292898_ChIP-Seq_THP-1_Human1.29660089
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.27754606
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.27306900
75SPI1_23127762_ChIP-Seq_K562_Human1.25832329
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25114430
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25090405
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24927933
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24898634
80GATA3_27048872_Chip-Seq_THYMUS_Human1.24416192
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23645453
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23136116
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22519329
84* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21098019
85E2F1_20622854_ChIP-Seq_HELA_Human1.20905393
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20854062
87* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20509381
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.19688944
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18098145
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18015586
91* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17763237
92CTCF_21964334_Chip-Seq_Bcells_Human1.16711620
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16077529
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15610262
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15014771
96GATA1_22025678_ChIP-Seq_K562_Human1.14348555
97ZNF263_19887448_ChIP-Seq_K562_Human1.14339389
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12245470
99NCOR1_26117541_ChIP-Seq_K562_Human1.10945812
100TP53_22127205_ChIP-Seq_IMR90_Human1.10806843
101CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10703230
102E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10420510
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09276332
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08636034
105* SA1_27219007_Chip-Seq_Bcells_Human1.07301606
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.06679881
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06091756
108GATA1_19941826_ChIP-Seq_K562_Human1.05982918
109* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05872251
110RARB_24833708_ChIP-Seq_LIVER_Mouse1.05221609
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.04505954
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04310046
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04141604
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04002798
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02922856
116* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02569908
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.01418864
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01377467
119* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00851902
120MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00746362
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00409790
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00342460
123TP63_22573176_ChIP-Seq_HFKS_Human1.00264557
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.00030358
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99903593
126BCL6_27268052_Chip-Seq_Bcells_Human0.99025246
127RACK7_27058665_Chip-Seq_MCF-7_Human0.98290991
128BCOR_27268052_Chip-Seq_Bcells_Human0.98260378
129* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97576334
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96486929
131P68_20966046_ChIP-Seq_HELA_Human0.94991104
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93944598
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92862482
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92518495
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.92407633
136TFEB_21752829_ChIP-Seq_HELA_Human0.92099545
137CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91435077
138* KDM5A_27292631_Chip-Seq_BREAST_Human0.90693836
139* PU_27001747_Chip-Seq_BMDM_Mouse0.90242746
140* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89426262
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.88343031
142E2F1_21310950_ChIP-Seq_MCF-7_Human0.88019205
143KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87808716
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87148820
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87111862
146MYC_18555785_ChIP-Seq_MESCs_Mouse0.86965312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system2.91999204
2MP0001835_abnormal_antigen_presentation2.86009709
3MP0003763_abnormal_thymus_physiology2.59521718
4MP0000678_abnormal_parathyroid_gland2.51511997
5MP0001800_abnormal_humoral_immune2.49054086
6MP0008260_abnormal_autophagy2.38433666
7MP0003300_gastrointestinal_ulcer2.34682333
8MP0002166_altered_tumor_susceptibility2.33626622
9MP0003436_decreased_susceptibility_to2.29554744
10MP0002396_abnormal_hematopoietic_system2.26945934
11MP0005410_abnormal_fertilization2.23221627
12MP0005671_abnormal_response_to2.11626259
13MP0002249_abnormal_larynx_morphology2.11567128
14MP0005387_immune_system_phenotype2.10011692
15MP0001790_abnormal_immune_system2.10011692
16MP0002398_abnormal_bone_marrow2.03272480
17MP0003705_abnormal_hypodermis_morpholog2.02487373
18MP0002452_abnormal_antigen_presenting1.99231822
19MP0003303_peritoneal_inflammation1.97877081
20MP0001348_abnormal_lacrimal_gland1.94923019
21MP0009840_abnormal_foam_cell1.92490019
22MP0010352_gastrointestinal_tract_polyps1.89355108
23MP0002420_abnormal_adaptive_immunity1.87333673
24MP0004808_abnormal_hematopoietic_stem1.85378614
25MP0001819_abnormal_immune_cell1.84778077
26MP0009278_abnormal_bone_marrow1.84615865
27MP0000689_abnormal_spleen_morphology1.84479333
28MP0002723_abnormal_immune_serum1.84123113
29MP0001873_stomach_inflammation1.79689221
30MP0000716_abnormal_immune_system1.77939501
31MP0002722_abnormal_immune_system1.73696025
32MP0004947_skin_inflammation1.72382862
33MP0005360_urolithiasis1.70190889
34MP0005000_abnormal_immune_tolerance1.67745072
35MP0005025_abnormal_response_to1.67042563
36MP0000703_abnormal_thymus_morphology1.66550049
37MP0002006_tumorigenesis1.65404195
38MP0005397_hematopoietic_system_phenotyp1.64697635
39MP0001545_abnormal_hematopoietic_system1.64697635
40MP0004381_abnormal_hair_follicle1.64168627
41MP0009785_altered_susceptibility_to1.63468821
42MP0010155_abnormal_intestine_physiology1.58480219
43MP0005464_abnormal_platelet_physiology1.56775930
44MP0002405_respiratory_system_inflammati1.55947691
45MP0002429_abnormal_blood_cell1.54617272
46MP0003806_abnormal_nucleotide_metabolis1.54010117
47MP0005310_abnormal_salivary_gland1.53792191
48MP0001853_heart_inflammation1.48755089
49MP0002419_abnormal_innate_immunity1.47182890
50MP0005365_abnormal_bile_salt1.44387709
51MP0002139_abnormal_hepatobiliary_system1.43440658
52MP0005023_abnormal_wound_healing1.39897790
53MP0004185_abnormal_adipocyte_glucose1.35652871
54MP0003183_abnormal_peptide_metabolism1.34823438
55MP0003566_abnormal_cell_adhesion1.30935427
56MP0000465_gastrointestinal_hemorrhage1.30308121
57MP0010234_abnormal_vibrissa_follicle1.29686760
58MP0001346_abnormal_lacrimal_gland1.29404498
59MP0001845_abnormal_inflammatory_respons1.28081130
60MP0000490_abnormal_crypts_of1.25372493
61MP0005076_abnormal_cell_differentiation1.21682125
62MP0003191_abnormal_cellular_cholesterol1.21250831
63MP0002098_abnormal_vibrissa_morphology1.20035263
64MP0000003_abnormal_adipose_tissue1.19852470
65MP0000609_abnormal_liver_physiology1.18693660
66MP0002019_abnormal_tumor_incidence1.18160231
67MP0006054_spinal_hemorrhage1.17662809
68MP0003693_abnormal_embryo_hatching1.17354371
69MP0010307_abnormal_tumor_latency1.15849679
70MP0010094_abnormal_chromosome_stability1.15535540
71MP0009333_abnormal_splenocyte_physiolog1.14297193
72MP0002933_joint_inflammation1.11808200
73MP0008007_abnormal_cellular_replicative1.11355494
74MP0000858_altered_metastatic_potential1.08663969
75MP0000313_abnormal_cell_death1.08531571
76MP0003786_premature_aging1.07846559
77MP0003077_abnormal_cell_cycle1.06012259
78MP0003172_abnormal_lysosome_physiology1.05992931
79MP0010329_abnormal_lipoprotein_level1.02846084
80MP0004957_abnormal_blastocyst_morpholog1.01651018
81MP0005501_abnormal_skin_physiology1.00350780
82MP0001849_ear_inflammation0.99865478
83MP0008469_abnormal_protein_level0.98935671
84MP0003453_abnormal_keratinocyte_physiol0.98708294
85MP0008961_abnormal_basal_metabolism0.98042343
86MP0005085_abnormal_gallbladder_physiolo0.97855663
87MP0002796_impaired_skin_barrier0.97367794
88MP0005623_abnormal_meninges_morphology0.96395278
89MP0009931_abnormal_skin_appearance0.95427563
90MP0003878_abnormal_ear_physiology0.94878193
91MP0005377_hearing/vestibular/ear_phenot0.94878193
92MP0005058_abnormal_lysosome_morphology0.94852189
93MP0000681_abnormal_thyroid_gland0.93956432
94MP0003111_abnormal_nucleus_morphology0.93289468
95MP0003252_abnormal_bile_duct0.92853302
96MP0002254_reproductive_system_inflammat0.91346033
97MP0000598_abnormal_liver_morphology0.90768523
98MP0005375_adipose_tissue_phenotype0.90184210
99MP0002132_abnormal_respiratory_system0.90127467
100MP0002138_abnormal_hepatobiliary_system0.89530465
101MP0003866_abnormal_defecation0.87966100
102MP0002148_abnormal_hypersensitivity_rea0.85808718
103MP0001929_abnormal_gametogenesis0.84392127
104MP0001243_abnormal_dermal_layer0.83932160
105MP0002060_abnormal_skin_morphology0.83509802
106MP0001533_abnormal_skeleton_physiology0.83299617
107MP0003698_abnormal_male_reproductive0.83230121
108MP0004858_abnormal_nervous_system0.82732329
109MP0006082_CNS_inflammation0.81757278
110MP0009763_increased_sensitivity_to0.81174482
111MP0001216_abnormal_epidermal_layer0.80956173
112MP0002009_preneoplasia0.80783036
113MP0000015_abnormal_ear_pigmentation0.80372626
114MP0003091_abnormal_cell_migration0.80162346
115MP0008057_abnormal_DNA_replication0.79881481
116MP0005174_abnormal_tail_pigmentation0.79781679
117MP0003279_aneurysm0.78890048
118MP0000569_abnormal_digit_pigmentation0.75709677
119MP0004510_myositis0.75507182
120MP0005621_abnormal_cell_physiology0.75459778
121MP0001730_embryonic_growth_arrest0.75057753
122MP0005451_abnormal_body_composition0.74800132
123MP0005670_abnormal_white_adipose0.73798540
124MP0009053_abnormal_anal_canal0.73602342
125MP0002080_prenatal_lethality0.73235409
126MP0004233_abnormal_muscle_weight0.72987564
127MP0000516_abnormal_urinary_system0.72930892
128MP0000350_abnormal_cell_proliferation0.71967647
129MP0005083_abnormal_biliary_tract0.71958023
130MP0010630_abnormal_cardiac_muscle0.71853850
131MP0000477_abnormal_intestine_morphology0.71572423
132MP0004264_abnormal_extraembryonic_tissu0.71015261
133MP0003656_abnormal_erythrocyte_physiolo0.70554116

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)4.08490069
2Recurrent bronchitis (HP:0002837)4.07786781
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.02359782
4Recurrent viral infections (HP:0004429)3.82437022
5B lymphocytopenia (HP:0010976)3.77385657
6Abnormality of B cell number (HP:0010975)3.77385657
7Agammaglobulinemia (HP:0004432)3.73813809
8Abnormality of the nasal mucosa (HP:0000433)3.69713111
9Panhypogammaglobulinemia (HP:0003139)3.52128994
10Papilloma (HP:0012740)3.49405902
11Verrucae (HP:0200043)3.49405902
12Chronic otitis media (HP:0000389)3.46387742
13Cellulitis (HP:0100658)3.35872332
14T lymphocytopenia (HP:0005403)3.35411215
15Colitis (HP:0002583)3.31078592
16Recurrent fungal infections (HP:0002841)3.26377342
17Septate vagina (HP:0001153)3.21722329
18Abnormality of T cell number (HP:0011839)3.19565679
19Gastrointestinal inflammation (HP:0004386)3.14332270
20Inflammation of the large intestine (HP:0002037)3.14093741
21Thyroiditis (HP:0100646)3.12687807
22Combined immunodeficiency (HP:0005387)3.05318304
23Abnormality of the fingertips (HP:0001211)2.98155064
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.96618748
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.87774191
26Progressive external ophthalmoplegia (HP:0000590)2.86925684
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.86463480
28Severe combined immunodeficiency (HP:0004430)2.86231443
29Hypoplasia of the thymus (HP:0000778)2.85042283
30Meningitis (HP:0001287)2.84816667
31Sparse lateral eyebrow (HP:0005338)2.81808040
32Pustule (HP:0200039)2.81707442
33Deep venous thrombosis (HP:0002625)2.75552652
34Severe visual impairment (HP:0001141)2.73511104
35Increased cerebral lipofuscin (HP:0011813)2.71255670
36Abnormality of T cells (HP:0002843)2.67776756
37Thrombocytosis (HP:0001894)2.65223361
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65027252
39Eczematoid dermatitis (HP:0000976)2.63629724
40Hypertensive crisis (HP:0100735)2.62031090
41Recurrent abscess formation (HP:0002722)2.59972177
42Bronchitis (HP:0012387)2.58526995
43IgM deficiency (HP:0002850)2.58074154
44Gastrointestinal infarctions (HP:0005244)2.56716939
45Hyperacusis (HP:0010780)2.54107149
46Emphysema (HP:0002097)2.51526311
47Recurrent sinusitis (HP:0011108)2.50576652
48Truncus arteriosus (HP:0001660)2.48052232
49Autoimmune thrombocytopenia (HP:0001973)2.47673265
50Elevated erythrocyte sedimentation rate (HP:0003565)2.44730914
51Recurrent bacterial skin infections (HP:0005406)2.43977620
52Cerebral aneurysm (HP:0004944)2.43954015
53Slow saccadic eye movements (HP:0000514)2.43616210
54Abnormality of macrophages (HP:0004311)2.41783187
55Bowel incontinence (HP:0002607)2.40710817
56Myocardial infarction (HP:0001658)2.35573599
57Chronic mucocutaneous candidiasis (HP:0002728)2.35088267
58Recurrent cutaneous fungal infections (HP:0011370)2.35088267
59Abnormal large intestine physiology (HP:0012700)2.30623981
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29756023
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.29521758
62Lymphopenia (HP:0001888)2.29368892
63Recurrent otitis media (HP:0000403)2.29337921
64Squamous cell carcinoma (HP:0002860)2.26781228
65Lip pit (HP:0100267)2.26292348
66Eosinophilia (HP:0001880)2.23726290
67Long palpebral fissure (HP:0000637)2.22747057
68Aplasia/Hypoplasia of the thymus (HP:0010515)2.22220922
69Increased IgE level (HP:0003212)2.21079929
70Deep palmar crease (HP:0006191)2.19078387
71Loss of speech (HP:0002371)2.18311033
72Abnormality of T cell physiology (HP:0011840)2.17314060
73Broad face (HP:0000283)2.16637076
74Vasculitis (HP:0002633)2.16481086
75Broad distal phalanx of finger (HP:0009836)2.16250164
76Abnormality of the aortic arch (HP:0012303)2.15847660
77Mitral stenosis (HP:0001718)2.15719071
78Recurrent skin infections (HP:0001581)2.15664920
79Reticulocytosis (HP:0001923)2.15433088
80Breast hypoplasia (HP:0003187)2.14431555
81Abnormality of the columella (HP:0009929)2.12864103
82Periodontitis (HP:0000704)2.12340408
83Gastrointestinal stroma tumor (HP:0100723)2.11988997
84Easy fatigability (HP:0003388)2.10695329
85Granulocytopenia (HP:0001913)2.10181483
86Xanthomatosis (HP:0000991)2.10036018
87Hypoparathyroidism (HP:0000829)2.09302180
88Osteomyelitis (HP:0002754)2.05614620
89Abnormal platelet volume (HP:0011876)2.04645144
90Gingival bleeding (HP:0000225)2.04632682
91Obstructive sleep apnea (HP:0002870)2.03905460
92Chronic sinusitis (HP:0011109)2.03366339
93Seborrheic dermatitis (HP:0001051)2.00320612
94Mediastinal lymphadenopathy (HP:0100721)2.00304331
95Myositis (HP:0100614)2.00180411
96Progressive muscle weakness (HP:0003323)2.00157814
97Orchitis (HP:0100796)1.99139774
98Hypochromic anemia (HP:0001931)1.98984661
99Sepsis (HP:0100806)1.98344730
100Skin ulcer (HP:0200042)1.97825052
101Hematochezia (HP:0002573)1.97495664
102Spontaneous hematomas (HP:0007420)1.96811193
103Abnormality of the thoracic spine (HP:0100711)1.96119121
104Poikiloderma (HP:0001029)1.95190372
105Basal cell carcinoma (HP:0002671)1.94717645
106Ulnar bowing (HP:0003031)1.94446536
107Epistaxis (HP:0000421)1.94357395
108Leukocytosis (HP:0001974)1.93313649
109Hyperthyroidism (HP:0000836)1.90960019
110Recurrent gram-negative bacterial infections (HP:0005420)1.90315408
111Malnutrition (HP:0004395)1.89583824
112Thin bony cortex (HP:0002753)1.89076312
113Abnormality of eosinophils (HP:0001879)1.88165140
114Intestinal fistula (HP:0100819)1.86677352
115Interstitial pulmonary disease (HP:0006530)1.86454410
116Impulsivity (HP:0100710)1.84916062
117IgG deficiency (HP:0004315)1.84442922
118Retrobulbar optic neuritis (HP:0100654)1.84141481
119Optic neuritis (HP:0100653)1.84141481
120Arterial thrombosis (HP:0004420)1.84015631
121Lymphoma (HP:0002665)1.83816223
122Abnormal gallbladder physiology (HP:0012438)1.82577522
123Cholecystitis (HP:0001082)1.82577522
124Chest pain (HP:0100749)1.82503091
125Trismus (HP:0000211)1.80882796
126Polycythemia (HP:0001901)1.79097057
127Upper motor neuron abnormality (HP:0002127)1.78649851
128Long eyelashes (HP:0000527)1.77476811
129Encephalitis (HP:0002383)1.77468309
130Abnormality of the distal phalanges of the toes (HP:0010182)1.77372247
131Thoracic kyphosis (HP:0002942)1.76183278
132Increased mean platelet volume (HP:0011877)1.75489743
133Dysmetric saccades (HP:0000641)1.75277042
134Restrictive lung disease (HP:0002091)1.74813073
135Gingivitis (HP:0000230)1.73773876
136Stridor (HP:0010307)1.72837150
137Skin rash (HP:0000988)1.72538545
138Abnormality of the thymus (HP:0000777)1.72313999
139Abnormality of the phalanges of the hallux (HP:0010057)1.70880058
140Personality changes (HP:0000751)1.69871927
141Entropion (HP:0000621)1.69468532
142Aortic aneurysm (HP:0004942)1.67170364
143Ureteral stenosis (HP:0000071)1.67138650
144Hyperlipoproteinemia (HP:0010980)1.66236308
145Unilateral renal agenesis (HP:0000122)1.66072741
146Distal upper limb amyotrophy (HP:0007149)1.65653469
147Upper limb amyotrophy (HP:0009129)1.65653469
148Spastic diplegia (HP:0001264)1.65429993
149Increased serum ferritin (HP:0003281)1.64431011
150Urethral obstruction (HP:0000796)1.64387488
151Bicuspid aortic valve (HP:0001647)1.64319370
152Heterotopia (HP:0002282)1.63995703
153Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63836982
154Prolonged bleeding time (HP:0003010)1.63200340
155Flattened epiphyses (HP:0003071)1.63163315
156Dislocated radial head (HP:0003083)1.62995593
157Ureteral obstruction (HP:0006000)1.62710341
158Obstructive lung disease (HP:0006536)1.62531089
159Chronic obstructive pulmonary disease (HP:0006510)1.62531089
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.62080294
161Abnormality of reticulocytes (HP:0004312)1.61171605
162Neonatal hypoglycemia (HP:0001998)1.60984395
163Hand muscle atrophy (HP:0009130)1.58769597
164Glossoptosis (HP:0000162)1.58482859
165Persistence of primary teeth (HP:0006335)1.58273024
166Microcytic anemia (HP:0001935)1.57431518
167Selective tooth agenesis (HP:0001592)1.57062558
168Germ cell neoplasia (HP:0100728)1.56527013
169Patellar dislocation (HP:0002999)1.56397740
170Hypergonadotropic hypogonadism (HP:0000815)1.56205852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.96443600
2MAP4K13.75673682
3ERN13.43468789
4SMG13.30852311
5TRIB33.24028325
6IRAK33.01642266
7PKN22.96401122
8EEF2K2.94498391
9PRPF4B2.80089591
10STK102.42152903
11GRK62.35151024
12TYK22.10527879
13LRRK22.04825601
14FGFR41.92109379
15SIK11.86232092
16BLK1.81413520
17ZAP701.81048261
18BTK1.76517824
19CDK121.76515806
20FLT31.74985533
21RIPK41.68540212
22NME21.67097444
23CSF1R1.64450644
24TBK11.63603388
25TAOK31.49379497
26NEK21.48701009
27TTN1.48041281
28MAP3K131.47980265
29JAK31.44779762
30ITK1.37358778
31MAP2K31.34566401
32PIM21.30502614
33KIT1.25599386
34MAP3K71.22413227
35CSK1.21671662
36IKBKE1.20612763
37TAOK21.17993373
38MST1R1.17618795
39CAMK1D1.17095967
40CDK41.15007816
41SYK1.14992432
42PTK61.13596729
43TEC1.13001833
44JAK11.10967153
45BRD41.10603714
46HCK1.08326508
47KSR21.04396077
48EPHB11.03157955
49IRAK21.02071756
50MAP3K11.01169736
51SIK21.00802248
52AKT31.00758511
53KDR0.99502729
54MAPKAPK30.99421984
55PDPK10.99307306
56STK40.99265673
57TLK10.96384613
58DYRK1B0.95983341
59PIM10.95254981
60MAP2K20.93545424
61MAP3K80.93445502
62RPS6KB20.93022495
63MAPK110.91606688
64TESK10.91181976
65CDK70.90595342
66RPS6KC10.89734674
67RPS6KL10.89734674
68CAMK1G0.87163767
69LCK0.87111678
70TGFBR20.85702902
71CDK90.85697139
72TAOK10.83832882
73FGFR30.82926733
74CDK60.82609884
75RPS6KA20.80354034
76TESK20.80262139
77BRAF0.79596015
78CDC42BPA0.78330771
79RPS6KA60.77809959
80NLK0.77587963
81ICK0.77550927
82STK380.76969033
83MARK30.76868164
84MAP3K140.73687145
85SIK30.72922206
86IKBKB0.72890143
87IRAK40.72635910
88MTOR0.72179721
89SCYL20.70772175
90RPS6KA10.69432676
91CHEK20.68380732
92MOS0.67741243
93PDK40.67014663
94PDK30.67014663
95PRKD30.64938089
96JAK20.64440864
97MAP3K30.62869877
98EPHA20.62108829
99LYN0.61621536
100RPS6KA40.59131725
101RIPK10.58736982
102AURKA0.57108834
103PASK0.56815737
104CDK80.56415571
105TXK0.55943692
106DYRK30.55464870
107BCKDK0.53323100
108MAPK150.53091894
109HIPK20.51459038
110DDR20.51148931
111MAP3K110.50993272
112IRAK10.50267559
113CHUK0.50101735
114PLK40.48198631
115RAF10.48047586
116CDK20.44619079
117MATK0.43223454
118FES0.42863613
119CDC70.42551549
120PRKD20.42394998
121MAPK40.42156408
122MAP2K60.41832745
123ATR0.41793299
124FGFR20.41035990
125RET0.40955222
126MARK20.40181956
127PDGFRB0.39342373
128PRKCI0.38855456
129TNK20.38469000
130ZAK0.37955652
131MST40.37521376
132MAPK80.36607677
133PRKCQ0.36154905
134RPS6KA50.36096773
135PAK40.35988511
136PDK10.35435191
137PAK20.35333670
138CLK10.32842368
139CHEK10.32798499
140PDGFRA0.32286176
141PTK20.32000485
142PRKD10.31188330
143BMX0.31178423

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.65052666
2B cell receptor signaling pathway_Homo sapiens_hsa046622.63557929
3Caffeine metabolism_Homo sapiens_hsa002322.08715385
4NF-kappa B signaling pathway_Homo sapiens_hsa040641.69442649
5Selenocompound metabolism_Homo sapiens_hsa004501.65898437
6Antigen processing and presentation_Homo sapiens_hsa046121.61071388
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55486181
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55428237
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.54202328
10Lysine degradation_Homo sapiens_hsa003101.49807917
11Measles_Homo sapiens_hsa051621.47564560
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46548407
13Leishmaniasis_Homo sapiens_hsa051401.46531461
14Acute myeloid leukemia_Homo sapiens_hsa052211.46123352
15Pentose phosphate pathway_Homo sapiens_hsa000301.45064976
16One carbon pool by folate_Homo sapiens_hsa006701.44836365
17T cell receptor signaling pathway_Homo sapiens_hsa046601.43926340
18Osteoclast differentiation_Homo sapiens_hsa043801.42602490
19mRNA surveillance pathway_Homo sapiens_hsa030151.38352587
20Base excision repair_Homo sapiens_hsa034101.37793711
21Chronic myeloid leukemia_Homo sapiens_hsa052201.33914745
22DNA replication_Homo sapiens_hsa030301.31240245
23Herpes simplex infection_Homo sapiens_hsa051681.28839448
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.25024518
25Hematopoietic cell lineage_Homo sapiens_hsa046401.24486421
26Non-homologous end-joining_Homo sapiens_hsa034501.24307639
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23685164
28Staphylococcus aureus infection_Homo sapiens_hsa051501.23034526
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22430919
30Toxoplasmosis_Homo sapiens_hsa051451.17133910
31Insulin resistance_Homo sapiens_hsa049311.14962555
32p53 signaling pathway_Homo sapiens_hsa041151.14188540
33Small cell lung cancer_Homo sapiens_hsa052221.13628080
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11026108
35ABC transporters_Homo sapiens_hsa020101.08957300
36Fatty acid degradation_Homo sapiens_hsa000711.08584724
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.08264314
38Allograft rejection_Homo sapiens_hsa053301.07522444
39Notch signaling pathway_Homo sapiens_hsa043301.07351370
40Other glycan degradation_Homo sapiens_hsa005111.06417726
41Sulfur relay system_Homo sapiens_hsa041221.06049871
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05091974
43Viral carcinogenesis_Homo sapiens_hsa052031.03459295
44Complement and coagulation cascades_Homo sapiens_hsa046101.03366842
45Apoptosis_Homo sapiens_hsa042101.03060923
46Prostate cancer_Homo sapiens_hsa052151.01824423
47Inositol phosphate metabolism_Homo sapiens_hsa005621.01709394
48ErbB signaling pathway_Homo sapiens_hsa040121.01206790
49Endometrial cancer_Homo sapiens_hsa052131.00684716
50Graft-versus-host disease_Homo sapiens_hsa053321.00641020
51Non-small cell lung cancer_Homo sapiens_hsa052231.00057231
52Influenza A_Homo sapiens_hsa051640.99858225
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.99291011
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.98470061
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97774268
56Hepatitis B_Homo sapiens_hsa051610.96129196
57Shigellosis_Homo sapiens_hsa051310.95625513
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94512414
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93668538
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93514763
61Renal cell carcinoma_Homo sapiens_hsa052110.93318018
62Fructose and mannose metabolism_Homo sapiens_hsa000510.92006651
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91556377
64RNA transport_Homo sapiens_hsa030130.91436316
65FoxO signaling pathway_Homo sapiens_hsa040680.89727145
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88979303
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88101920
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88062560
69Systemic lupus erythematosus_Homo sapiens_hsa053220.87455716
70Glioma_Homo sapiens_hsa052140.86938078
71Nitrogen metabolism_Homo sapiens_hsa009100.86492479
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.86025779
73Pancreatic cancer_Homo sapiens_hsa052120.85229215
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84582736
75HTLV-I infection_Homo sapiens_hsa051660.84461038
76Type II diabetes mellitus_Homo sapiens_hsa049300.83840014
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83190916
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.82446283
79Bladder cancer_Homo sapiens_hsa052190.82396656
80Autoimmune thyroid disease_Homo sapiens_hsa053200.82387943
81Viral myocarditis_Homo sapiens_hsa054160.81803107
82Biosynthesis of amino acids_Homo sapiens_hsa012300.79210134
83Fatty acid biosynthesis_Homo sapiens_hsa000610.77940247
84PPAR signaling pathway_Homo sapiens_hsa033200.76746054
85Tryptophan metabolism_Homo sapiens_hsa003800.75808035
86VEGF signaling pathway_Homo sapiens_hsa043700.74990876
87Insulin signaling pathway_Homo sapiens_hsa049100.73211893
88Colorectal cancer_Homo sapiens_hsa052100.73131920
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.73090811
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.72750378
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.72285196
92Endocytosis_Homo sapiens_hsa041440.72177258
93Platelet activation_Homo sapiens_hsa046110.71665732
94Choline metabolism in cancer_Homo sapiens_hsa052310.71639520
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70960544
96mTOR signaling pathway_Homo sapiens_hsa041500.70765053
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70226933
98Dorso-ventral axis formation_Homo sapiens_hsa043200.70187823
99Epstein-Barr virus infection_Homo sapiens_hsa051690.69901335
100Alcoholism_Homo sapiens_hsa050340.69305778
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69110975
102MicroRNAs in cancer_Homo sapiens_hsa052060.67906457
103Legionellosis_Homo sapiens_hsa051340.67481729
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65675159
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65403730
106HIF-1 signaling pathway_Homo sapiens_hsa040660.63742977
107Carbon metabolism_Homo sapiens_hsa012000.63686069
108Fatty acid metabolism_Homo sapiens_hsa012120.63248259
109Malaria_Homo sapiens_hsa051440.63182870
110TNF signaling pathway_Homo sapiens_hsa046680.62761685
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.61332025
112MAPK signaling pathway_Homo sapiens_hsa040100.60777476
113Chemokine signaling pathway_Homo sapiens_hsa040620.59705084
114Arginine biosynthesis_Homo sapiens_hsa002200.59112686
115Lysosome_Homo sapiens_hsa041420.58118457
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57868194
117Glycerolipid metabolism_Homo sapiens_hsa005610.57184337
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56523623
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55449520
120Mismatch repair_Homo sapiens_hsa034300.54669175
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.54078323
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53823254
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53585262
124Hepatitis C_Homo sapiens_hsa051600.53389357
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52550657
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51992936
127Spliceosome_Homo sapiens_hsa030400.51249847
128Cell cycle_Homo sapiens_hsa041100.51008635
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50731343
130N-Glycan biosynthesis_Homo sapiens_hsa005100.50302546
131Thyroid cancer_Homo sapiens_hsa052160.49977086
132Tuberculosis_Homo sapiens_hsa051520.49763033
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49736093
134Prolactin signaling pathway_Homo sapiens_hsa049170.47671116
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47472787
136Proteoglycans in cancer_Homo sapiens_hsa052050.45493019

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