TRIM13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.99233933
2central nervous system myelination (GO:0022010)8.99233933
3negative regulation of mast cell activation (GO:0033004)8.25771954
4lung lobe morphogenesis (GO:0060463)7.75195007
5polarized epithelial cell differentiation (GO:0030859)6.58929949
6respiratory tube development (GO:0030323)6.57126542
7fatty acid elongation (GO:0030497)6.22452822
8lung vasculature development (GO:0060426)6.15371530
9establishment or maintenance of monopolar cell polarity (GO:0061339)5.96605358
10establishment of monopolar cell polarity (GO:0061162)5.96605358
11establishment of apical/basal cell polarity (GO:0035089)5.44331259
12ensheathment of neurons (GO:0007272)5.40081107
13axon ensheathment (GO:0008366)5.40081107
14myelination (GO:0042552)5.36018362
15embryonic foregut morphogenesis (GO:0048617)5.35827214
16endocardial cushion development (GO:0003197)5.22403828
17long-chain fatty acid biosynthetic process (GO:0042759)5.20899928
18cardiac left ventricle morphogenesis (GO:0003214)4.95276216
19midgut development (GO:0007494)4.73116689
20piRNA metabolic process (GO:0034587)4.70151440
21lung morphogenesis (GO:0060425)4.43608019
22glycerophospholipid catabolic process (GO:0046475)4.37758692
23regulation of collateral sprouting (GO:0048670)4.28049602
24cholesterol biosynthetic process (GO:0006695)4.15354459
25negative regulation of execution phase of apoptosis (GO:1900118)4.14371912
26renal system development (GO:0072001)4.02917411
27DNA double-strand break processing (GO:0000729)3.97385064
28establishment of epithelial cell polarity (GO:0090162)3.88817408
29isoprenoid biosynthetic process (GO:0008299)3.87319744
30preassembly of GPI anchor in ER membrane (GO:0016254)3.76491605
31GPI anchor biosynthetic process (GO:0006506)3.75457131
32behavioral response to nicotine (GO:0035095)3.70297285
33sterol biosynthetic process (GO:0016126)3.66622983
34pancreas development (GO:0031016)3.66385225
35microtubule polymerization or depolymerization (GO:0031109)3.66186797
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.65071606
37DNA deamination (GO:0045006)3.59896993
38chaperone-mediated protein transport (GO:0072321)3.58959913
39DNA methylation involved in gamete generation (GO:0043046)3.54511186
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54011971
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49127072
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.49127072
43NADH dehydrogenase complex assembly (GO:0010257)3.49127072
44regulation of exit from mitosis (GO:0007096)3.48205702
45amyloid precursor protein metabolic process (GO:0042982)3.45182457
46embryonic digestive tract morphogenesis (GO:0048557)3.41169493
47GPI anchor metabolic process (GO:0006505)3.39888081
48positive regulation of actin filament depolymerization (GO:0030836)3.38484778
49mitotic metaphase plate congression (GO:0007080)3.34930043
50pyrimidine nucleobase catabolic process (GO:0006208)3.33623016
51protein neddylation (GO:0045116)3.30979299
52eye photoreceptor cell differentiation (GO:0001754)3.30262366
53photoreceptor cell differentiation (GO:0046530)3.30262366
54mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.28729845
55positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.28729845
56neural tube formation (GO:0001841)3.28450479
57negative regulation of exocytosis (GO:0045920)3.25693691
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.22580757
59maturation of 5.8S rRNA (GO:0000460)3.21708133
60regulation of DNA endoreduplication (GO:0032875)3.19703766
61protein complex biogenesis (GO:0070271)3.19574689
62ubiquinone metabolic process (GO:0006743)3.17651589
63regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.16415452
64establishment of mitochondrion localization (GO:0051654)3.16126291
65protein K6-linked ubiquitination (GO:0085020)3.12084041
66indole-containing compound catabolic process (GO:0042436)3.11058525
67indolalkylamine catabolic process (GO:0046218)3.11058525
68tryptophan catabolic process (GO:0006569)3.11058525
69sulfation (GO:0051923)3.10218760
70proteasome assembly (GO:0043248)3.09708191
71synapsis (GO:0007129)3.09051181
72regulation of pigment cell differentiation (GO:0050932)3.08805214
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07587032
74negative regulation of neurotransmitter secretion (GO:0046929)3.07231640
75response to redox state (GO:0051775)3.06632486
76oligodendrocyte differentiation (GO:0048709)3.06194726
77positive regulation of oligodendrocyte differentiation (GO:0048714)3.03479639
78spinal cord motor neuron differentiation (GO:0021522)3.03236996
79somite development (GO:0061053)3.02575540
80meiotic cell cycle (GO:0051321)3.02564283
81negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.00697105
82female gamete generation (GO:0007292)3.00216360
83male meiosis (GO:0007140)2.99864548
84transcription elongation from RNA polymerase III promoter (GO:0006385)2.98975308
85termination of RNA polymerase III transcription (GO:0006386)2.98975308
86kidney morphogenesis (GO:0060993)2.95165693
87protein polyglutamylation (GO:0018095)2.94662492
88mitochondrial respiratory chain complex assembly (GO:0033108)2.93715447
89myelin maintenance (GO:0043217)2.91677832
90replicative senescence (GO:0090399)2.87202435
91base-excision repair, AP site formation (GO:0006285)2.85957014
92cornea development in camera-type eye (GO:0061303)2.84033019
93regulation of smooth muscle cell differentiation (GO:0051150)2.83868483
94water-soluble vitamin biosynthetic process (GO:0042364)2.82590883
95establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.82294065
96presynaptic membrane assembly (GO:0097105)2.82198663
97regulation of female gonad development (GO:2000194)2.81397350
98organ growth (GO:0035265)2.81266583
99microtubule severing (GO:0051013)2.80498253
100negative regulation of protein localization to cell surface (GO:2000009)2.80470175
1017-methylguanosine RNA capping (GO:0009452)2.80190041
102RNA capping (GO:0036260)2.80190041
1037-methylguanosine mRNA capping (GO:0006370)2.78776194
104replication fork processing (GO:0031297)2.78430134
105meiotic chromosome segregation (GO:0045132)2.78172736
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78047003
107multicellular organism reproduction (GO:0032504)2.76107948
108ear development (GO:0043583)2.74960993
109microtubule depolymerization (GO:0007019)2.74949781
110ribosome assembly (GO:0042255)2.74244221
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73192882
112otic vesicle formation (GO:0030916)2.70373553
113indolalkylamine metabolic process (GO:0006586)2.70170541
114prostate gland growth (GO:0060736)2.69624025
115substantia nigra development (GO:0021762)2.69210194
116metaphase plate congression (GO:0051310)2.68855706
117detection of light stimulus involved in sensory perception (GO:0050962)2.68416897
118detection of light stimulus involved in visual perception (GO:0050908)2.68416897
119negative regulation of neurotransmitter transport (GO:0051589)2.68302812
120mitochondrial RNA metabolic process (GO:0000959)2.68138992
121kynurenine metabolic process (GO:0070189)2.68070918
122DNA demethylation (GO:0080111)2.67880906
123nucleobase catabolic process (GO:0046113)2.67533495
124presynaptic membrane organization (GO:0097090)2.67404505
125magnesium ion transport (GO:0015693)2.65928414
126amino acid salvage (GO:0043102)2.64462516
127L-methionine salvage (GO:0071267)2.64462516
128L-methionine biosynthetic process (GO:0071265)2.64462516
129amyloid precursor protein catabolic process (GO:0042987)2.62540521
130membrane tubulation (GO:0097320)2.62280775
131sphingosine metabolic process (GO:0006670)2.61912682
132centriole replication (GO:0007099)2.61124882
133apical protein localization (GO:0045176)2.61118353
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58896261
135isotype switching (GO:0045190)2.58896261
136somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58896261
137negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58403543
138positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.58167204
139L-fucose catabolic process (GO:0042355)2.57995027
140fucose catabolic process (GO:0019317)2.57995027
141L-fucose metabolic process (GO:0042354)2.57995027
142transcription elongation from RNA polymerase II promoter (GO:0006368)2.57680628
143double-strand break repair via homologous recombination (GO:0000724)2.57449529
144female gonad development (GO:0008585)2.57281816
145recombinational repair (GO:0000725)2.57120641
146regulation of DNA methylation (GO:0044030)2.56029584
147positive regulation of megakaryocyte differentiation (GO:0045654)2.55613921
148parental behavior (GO:0060746)2.55194324
149chromatin remodeling at centromere (GO:0031055)2.54259043
150negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.54089270
151regulation of mesoderm development (GO:2000380)2.53714198
152CENP-A containing nucleosome assembly (GO:0034080)2.53624228
153mannosylation (GO:0097502)2.53553164
154protein deneddylation (GO:0000338)2.52813178
155tryptophan metabolic process (GO:0006568)2.51972398
156asymmetric protein localization (GO:0008105)2.51850443
157regulation of spindle checkpoint (GO:0090231)2.51185965
158epithelial cilium movement (GO:0003351)2.51122189
159regulation of meiosis I (GO:0060631)2.50943623
160negative regulation of transcription by competitive promoter binding (GO:0010944)2.50544672
161regulation of helicase activity (GO:0051095)2.50300777
162response to lipoprotein particle (GO:0055094)2.49875817
163long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.49090825
164mesodermal cell differentiation (GO:0048333)2.48631535
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48279618
166positive regulation of pseudopodium assembly (GO:0031274)2.48240175
167rRNA modification (GO:0000154)2.48163538
168rRNA methylation (GO:0031167)2.47783945
169DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.47593343
170limb bud formation (GO:0060174)2.47406550
171tissue regeneration (GO:0042246)2.47003435
172axoneme assembly (GO:0035082)2.46373259
173cardiac ventricle morphogenesis (GO:0003208)2.46200256
174respiratory chain complex IV assembly (GO:0008535)2.45590455
175sympathetic nervous system development (GO:0048485)2.44388057
176detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44180221
177astrocyte development (GO:0014002)2.43476349
178neuron remodeling (GO:0016322)2.42405413
179reciprocal DNA recombination (GO:0035825)2.42351170
180reciprocal meiotic recombination (GO:0007131)2.42351170
181positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.41935746
182DNA-templated transcription, elongation (GO:0006354)2.41628778
183gamma-aminobutyric acid transport (GO:0015812)2.41397560
184cilium morphogenesis (GO:0060271)2.41128975
185attachment of spindle microtubules to kinetochore (GO:0008608)2.41028572
186behavioral response to ethanol (GO:0048149)2.38686202
187RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38642782
188cell differentiation in spinal cord (GO:0021515)2.38581469
189cilium organization (GO:0044782)2.38533015
190regulation of meiosis (GO:0040020)2.38215065
191forebrain neuron differentiation (GO:0021879)2.37520897
192nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37274088
193regulation of telomere maintenance via telomerase (GO:0032210)2.35658614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.73245146
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.57716979
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.20970568
4ZNF274_21170338_ChIP-Seq_K562_Hela3.07244993
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03079488
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.96253439
7* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74546644
8EZH2_22144423_ChIP-Seq_EOC_Human2.64996796
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59102127
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.55699028
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40346525
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39717252
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36519762
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31559779
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30619551
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.23291909
17P300_19829295_ChIP-Seq_ESCs_Human2.22690879
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13770391
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.10440798
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07922294
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03722994
22IRF1_19129219_ChIP-ChIP_H3396_Human2.03376250
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99058237
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98771168
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98771168
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98771168
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93103268
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.92653079
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89435882
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88505407
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.84722129
32FUS_26573619_Chip-Seq_HEK293_Human1.81895973
33BCAT_22108803_ChIP-Seq_LS180_Human1.80124477
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79844854
35VDR_22108803_ChIP-Seq_LS180_Human1.78816121
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78688705
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76795275
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72915117
39LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72259314
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71098662
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68859174
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65034532
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65034532
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64922532
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64403294
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.64196748
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62894898
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61316349
49* AR_21909140_ChIP-Seq_LNCAP_Human1.61152825
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.55074645
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51595399
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51550591
53SMAD4_21799915_ChIP-Seq_A2780_Human1.51379876
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51134589
55CBP_20019798_ChIP-Seq_JUKART_Human1.50778934
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50778934
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.50270265
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49349645
59STAT3_23295773_ChIP-Seq_U87_Human1.49255689
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.47702716
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.46645087
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46145188
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.45677397
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.44614704
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43669578
66VDR_23849224_ChIP-Seq_CD4+_Human1.42781901
67AR_25329375_ChIP-Seq_VCAP_Human1.42041667
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41948105
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.41070669
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39923845
71TP53_22573176_ChIP-Seq_HFKS_Human1.38207911
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37322626
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36010364
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.34984773
75TCF4_23295773_ChIP-Seq_U87_Human1.34838385
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.33213348
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32734471
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32295269
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32094279
80RNF2_27304074_Chip-Seq_NSC_Mouse1.31327645
81GBX2_23144817_ChIP-Seq_PC3_Human1.31004186
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.30411171
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25555846
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24118948
85TAF15_26573619_Chip-Seq_HEK293_Human1.23988966
86* EWS_26573619_Chip-Seq_HEK293_Human1.23429527
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22809132
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.22345588
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20946572
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.20742779
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20289944
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18704221
93SOX17_20123909_ChIP-Seq_XEN_Mouse1.18393699
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.18035518
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17542747
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17408355
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17368388
98TCF4_22108803_ChIP-Seq_LS180_Human1.17104108
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.16720222
100ER_23166858_ChIP-Seq_MCF-7_Human1.16686368
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16019885
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15338342
103P53_22387025_ChIP-Seq_ESCs_Mouse1.15204554
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14978764
105* NANOG_19829295_ChIP-Seq_ESCs_Human1.14436369
106* SOX2_19829295_ChIP-Seq_ESCs_Human1.14436369
107HTT_18923047_ChIP-ChIP_STHdh_Human1.13769241
108ELK1_19687146_ChIP-ChIP_HELA_Human1.13058058
109* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12978990
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12607856
111* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12450086
112RUNX2_22187159_ChIP-Seq_PCA_Human1.11008993
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09995389
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.08404704
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08211315
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08119163
117IGF1R_20145208_ChIP-Seq_DFB_Human1.08075640
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07680974
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.06375727
120EOMES_21245162_ChIP-Seq_HESCs_Human1.05703442
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05596586
122* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05202515
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.05143297
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.04058093
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03991576
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03803076
127TP53_16413492_ChIP-PET_HCT116_Human1.02861016
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02649087
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02450627
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01006076
131* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00995398
132NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99566661
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99446305
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99404876
135* SMAD4_21741376_ChIP-Seq_EPCs_Human0.99124750
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98856553
137CDX2_22108803_ChIP-Seq_LS180_Human0.98279157
138REST_21632747_ChIP-Seq_MESCs_Mouse0.98260766
139KDM2B_26808549_Chip-Seq_REH_Human0.97661043
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97096118
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97087375
142KLF4_18555785_Chip-Seq_ESCs_Mouse0.96609319
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95961328
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95319093
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95278326
146P300_18555785_Chip-Seq_ESCs_Mouse0.94476650
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.93550396
148TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92724001
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.91047934
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90542977
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90384521
152MYC_18940864_ChIP-ChIP_HL60_Human0.90183892
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89269145
154MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88897053
155RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87539940
156EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87025500
157TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86707800
158SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86295511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.05903455
2MP0003950_abnormal_plasma_membrane3.83966451
3MP0003718_maternal_effect3.75225940
4MP0003136_yellow_coat_color3.49199105
5MP0005451_abnormal_body_composition3.40429087
6MP0008260_abnormal_autophagy3.10451358
7MP0000569_abnormal_digit_pigmentation2.93320733
8MP0001188_hyperpigmentation2.73870031
9MP0001529_abnormal_vocalization2.73461191
10MP0009379_abnormal_foot_pigmentation2.53023256
11MP0002638_abnormal_pupillary_reflex2.41707609
12MP0001968_abnormal_touch/_nociception2.38096437
13MP0005174_abnormal_tail_pigmentation2.31115066
14MP0005410_abnormal_fertilization2.21296847
15MP0003806_abnormal_nucleotide_metabolis2.19384539
16MP0003787_abnormal_imprinting2.19094303
17MP0005171_absent_coat_pigmentation2.17421608
18MP0005187_abnormal_penis_morphology2.14122509
19MP0008877_abnormal_DNA_methylation2.12892932
20MP0002736_abnormal_nociception_after2.11161577
21MP0005408_hypopigmentation2.09045488
22MP0002102_abnormal_ear_morphology2.08519903
23MP0001905_abnormal_dopamine_level2.08238967
24MP0000383_abnormal_hair_follicle2.00533399
25MP0001485_abnormal_pinna_reflex1.99674766
26MP0003693_abnormal_embryo_hatching1.96467112
27MP0010094_abnormal_chromosome_stability1.95472453
28MP0008057_abnormal_DNA_replication1.94574875
29MP0003880_abnormal_central_pattern1.92302829
30MP0001346_abnormal_lacrimal_gland1.91952774
31MP0004381_abnormal_hair_follicle1.87739573
32MP0006292_abnormal_olfactory_placode1.82980961
33MP0003937_abnormal_limbs/digits/tail_de1.76452379
34MP0003077_abnormal_cell_cycle1.76432600
35MP0001929_abnormal_gametogenesis1.72640183
36MP0002751_abnormal_autonomic_nervous1.70444614
37MP0005253_abnormal_eye_physiology1.67678240
38MP0004742_abnormal_vestibular_system1.67417277
39MP0002210_abnormal_sex_determination1.66028123
40MP0005551_abnormal_eye_electrophysiolog1.65979284
41MP0004043_abnormal_pH_regulation1.65431025
42MP0005646_abnormal_pituitary_gland1.64217435
43MP0005395_other_phenotype1.64078059
44MP0010678_abnormal_skin_adnexa1.63706519
45MP0003632_abnormal_nervous_system1.62508447
46MP0003121_genomic_imprinting1.62051479
47MP0010386_abnormal_urinary_bladder1.60754229
48MP0003690_abnormal_glial_cell1.59254339
49MP0008932_abnormal_embryonic_tissue1.58566497
50MP0000566_synostosis1.57164853
51MP0002735_abnormal_chemical_nociception1.56246328
52MP0004957_abnormal_blastocyst_morpholog1.56090022
53MP0000579_abnormal_nail_morphology1.55974522
54MP0002653_abnormal_ependyma_morphology1.53434242
55MP0002163_abnormal_gland_morphology1.50179798
56MP0000631_abnormal_neuroendocrine_gland1.48611273
57MP0008058_abnormal_DNA_repair1.47614511
58MP0000653_abnormal_sex_gland1.44445587
59MP0009745_abnormal_behavioral_response1.44277139
60MP0000462_abnormal_digestive_system1.43126155
61MP0000778_abnormal_nervous_system1.42336374
62MP0004885_abnormal_endolymph1.40995858
63MP0003329_amyloid_beta_deposits1.40058669
64MP0003111_abnormal_nucleus_morphology1.39687910
65MP0008007_abnormal_cellular_replicative1.37220025
66MP0002876_abnormal_thyroid_physiology1.35999671
67MP0004270_analgesia1.35592699
68MP0006276_abnormal_autonomic_nervous1.34662477
69MP0009046_muscle_twitch1.34098468
70MP0000015_abnormal_ear_pigmentation1.33496426
71MP0002095_abnormal_skin_pigmentation1.32832093
72MP0002938_white_spotting1.32345338
73MP0001145_abnormal_male_reproductive1.30154989
74MP0000647_abnormal_sebaceous_gland1.29355179
75MP0003698_abnormal_male_reproductive1.29202093
76MP0004142_abnormal_muscle_tone1.28575037
77MP0002837_dystrophic_cardiac_calcinosis1.27819034
78MP0002067_abnormal_sensory_capabilities1.25785151
79MP0005645_abnormal_hypothalamus_physiol1.25049552
80MP0001851_eye_inflammation1.22784622
81MP0003634_abnormal_glial_cell1.22632320
82MP0004924_abnormal_behavior1.19884416
83MP0005386_behavior/neurological_phenoty1.19884416
84MP0003938_abnormal_ear_development1.18605942
85MP0000427_abnormal_hair_cycle1.17023212
86MP0000372_irregular_coat_pigmentation1.16478687
87MP0002234_abnormal_pharynx_morphology1.16040232
88MP0005409_darkened_coat_color1.14199991
89MP0003635_abnormal_synaptic_transmissio1.11572835
90MP0004147_increased_porphyrin_level1.11019490
91MP0003252_abnormal_bile_duct1.09941386
92MP0002229_neurodegeneration1.09906688
93MP0008872_abnormal_physiological_respon1.08311345
94MP0003315_abnormal_perineum_morphology1.08289575
95MP0004215_abnormal_myocardial_fiber1.07585699
96MP0002184_abnormal_innervation1.06908824
97MP0002161_abnormal_fertility/fecundity1.06810477
98MP0003699_abnormal_female_reproductive1.05523133
99MP0002160_abnormal_reproductive_system1.05311384
100MP0000762_abnormal_tongue_morphology1.04455554
101MP0005084_abnormal_gallbladder_morpholo1.03308936
102MP0000049_abnormal_middle_ear1.02524752
103MP0003786_premature_aging1.01595310
104MP0002557_abnormal_social/conspecific_i1.00735929
105MP0000613_abnormal_salivary_gland1.00696672
106MP0002928_abnormal_bile_duct0.97685123
107MP0005379_endocrine/exocrine_gland_phen0.97258575
108MP0000516_abnormal_urinary_system0.96902027
109MP0005367_renal/urinary_system_phenotyp0.96902027
110MP0001730_embryonic_growth_arrest0.96310261
111MP0002277_abnormal_respiratory_mucosa0.94500060
112MP0005423_abnormal_somatic_nervous0.93373665
113MP0002295_abnormal_pulmonary_circulatio0.93281614
114MP0003119_abnormal_digestive_system0.93174167
115MP0002572_abnormal_emotion/affect_behav0.92681015
116MP0003646_muscle_fatigue0.91753294
117MP0005389_reproductive_system_phenotype0.91733445
118MP0001119_abnormal_female_reproductive0.91340463
119MP0003755_abnormal_palate_morphology0.90394098
120MP0002752_abnormal_somatic_nervous0.90347717
121MP0006072_abnormal_retinal_apoptosis0.90142796
122MP0001984_abnormal_olfaction0.89578730
123MP0002098_abnormal_vibrissa_morphology0.88991061
124MP0002249_abnormal_larynx_morphology0.86582709
125MP0001293_anophthalmia0.86324241
126MP0003195_calcinosis0.86323665
127MP0002063_abnormal_learning/memory/cond0.85587394
128MP0002064_seizures0.85284415
129MP0002734_abnormal_mechanical_nocicepti0.84951730
130MP0004133_heterotaxia0.84582326
131MP0001963_abnormal_hearing_physiology0.84539031
132MP0008789_abnormal_olfactory_epithelium0.83928554
133MP0003011_delayed_dark_adaptation0.83528839
134MP0001970_abnormal_pain_threshold0.82565521
135MP0002733_abnormal_thermal_nociception0.82195483
136MP0006082_CNS_inflammation0.81794359
137MP0003122_maternal_imprinting0.81747764
138MP0005394_taste/olfaction_phenotype0.81563539
139MP0005499_abnormal_olfactory_system0.81563539
140MP0003567_abnormal_fetal_cardiomyocyte0.81115952
141MP0003453_abnormal_keratinocyte_physiol0.81108362
142MP0003890_abnormal_embryonic-extraembry0.79698186
143MP0002272_abnormal_nervous_system0.79566017
144MP0005195_abnormal_posterior_eye0.79170698
145MP0000467_abnormal_esophagus_morphology0.78981959
146MP0003186_abnormal_redox_activity0.78710980
147MP0009250_abnormal_appendicular_skeleto0.78610268
148MP0001486_abnormal_startle_reflex0.77733013
149MP0000465_gastrointestinal_hemorrhage0.76422195
150MP0002085_abnormal_embryonic_tissue0.75263322
151MP0008995_early_reproductive_senescence0.75016445
152MP0002138_abnormal_hepatobiliary_system0.74593507
153MP0000026_abnormal_inner_ear0.73574751
154MP0000350_abnormal_cell_proliferation0.72430838
155MP0001727_abnormal_embryo_implantation0.71354203
156MP0009333_abnormal_splenocyte_physiolog0.70083004
157MP0003861_abnormal_nervous_system0.69248554
158MP0004134_abnormal_chest_morphology0.68556419
159MP0001986_abnormal_taste_sensitivity0.66366775
160MP0000604_amyloidosis0.65644480
161MP0000955_abnormal_spinal_cord0.64893950
162MP0002254_reproductive_system_inflammat0.61705714

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)7.37116562
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.49301287
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.49301287
4Abnormality of the pulmonary veins (HP:0011718)5.46372867
5Parakeratosis (HP:0001036)5.38644647
6Cerebral hypomyelination (HP:0006808)5.15878165
7Meckel diverticulum (HP:0002245)4.25558769
8Abnormality of the ileum (HP:0001549)4.19076656
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.96513728
10Pancreatic cysts (HP:0001737)3.87972160
11Abnormality of the corticospinal tract (HP:0002492)3.80707522
12Annular pancreas (HP:0001734)3.79232598
13Abnormality of glycolysis (HP:0004366)3.68144987
14Increased serum pyruvate (HP:0003542)3.68144987
15Abnormal umbilical cord blood vessels (HP:0011403)3.66449917
16Single umbilical artery (HP:0001195)3.66449917
17Abnormality of the fetal cardiovascular system (HP:0010948)3.66449917
18Neurofibrillary tangles (HP:0002185)3.45149067
19True hermaphroditism (HP:0010459)3.44215302
20Pancreatic fibrosis (HP:0100732)3.37683500
21Adrenal hypoplasia (HP:0000835)3.36014454
22Peripheral hypomyelination (HP:0007182)3.35623067
23Birth length less than 3rd percentile (HP:0003561)3.33659904
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.32040247
25Absent septum pellucidum (HP:0001331)3.31743459
26Abnormal lung lobation (HP:0002101)3.31092476
27Sensory axonal neuropathy (HP:0003390)3.26674761
28Abnormality of the labia minora (HP:0012880)3.14294945
29CNS hypomyelination (HP:0003429)3.13070632
30Abnormality of midbrain morphology (HP:0002418)3.12411340
31Molar tooth sign on MRI (HP:0002419)3.12411340
32Hyperventilation (HP:0002883)3.08169917
33Hydroureter (HP:0000072)3.06804922
34Abnormality of the septum pellucidum (HP:0007375)3.01297368
35Breast hypoplasia (HP:0003187)2.97132096
36Morphological abnormality of the inner ear (HP:0011390)2.94955441
37Nephronophthisis (HP:0000090)2.94658611
38Small intestinal stenosis (HP:0012848)2.87803883
39Duodenal stenosis (HP:0100867)2.87803883
40Colon cancer (HP:0003003)2.86657731
41Stenosis of the external auditory canal (HP:0000402)2.84599446
42Hypoplastic left heart (HP:0004383)2.83151061
43Congenital ichthyosiform erythroderma (HP:0007431)2.80487055
44Congenital stationary night blindness (HP:0007642)2.63807529
45Duplicated collecting system (HP:0000081)2.57175613
46Hypoplastic pelvis (HP:0008839)2.55506974
47Abnormality of the renal medulla (HP:0100957)2.53851491
48Abnormality of the duodenum (HP:0002246)2.53667374
49Abnormality of the renal collecting system (HP:0004742)2.51349972
50Spastic gait (HP:0002064)2.48729588
51Neoplasm of the adrenal cortex (HP:0100641)2.47634012
52Segmental peripheral demyelination/remyelination (HP:0003481)2.47463149
53Retinal dysplasia (HP:0007973)2.47379427
54Esophageal atresia (HP:0002032)2.46277236
55Spastic paraparesis (HP:0002313)2.45692308
56Septo-optic dysplasia (HP:0100842)2.38267726
57Cupped ear (HP:0000378)2.37209799
58Onion bulb formation (HP:0003383)2.36652682
59Male infertility (HP:0003251)2.35272452
60Split foot (HP:0001839)2.34809120
61Hypoplastic heart (HP:0001961)2.33984374
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33180411
63Leukodystrophy (HP:0002415)2.29981389
64Postnatal microcephaly (HP:0005484)2.29790060
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.27253228
66Thyroiditis (HP:0100646)2.26953768
67Patchy hypopigmentation of hair (HP:0011365)2.26202877
68Renal Fanconi syndrome (HP:0001994)2.22901535
69White forelock (HP:0002211)2.22677726
70Hypoplasia of the uterus (HP:0000013)2.22518163
71Abolished electroretinogram (ERG) (HP:0000550)2.22101094
72Alacrima (HP:0000522)2.16039200
73Methylmalonic acidemia (HP:0002912)2.15938879
74Absent radius (HP:0003974)2.15904388
75Insidious onset (HP:0003587)2.15523170
76Termporal pattern (HP:0011008)2.15523170
77Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15261920
78Akinesia (HP:0002304)2.15091869
79Abnormality of cochlea (HP:0000375)2.14732387
80Supernumerary spleens (HP:0009799)2.13106699
81Cystic liver disease (HP:0006706)2.12773818
82Absent forearm bone (HP:0003953)2.10395904
83Aplasia involving forearm bones (HP:0009822)2.10395904
84Abnormality of the renal cortex (HP:0011035)2.10134848
85Stomach cancer (HP:0012126)2.09089636
86Abnormal auditory evoked potentials (HP:0006958)2.08988062
87Gaze-evoked nystagmus (HP:0000640)2.08657114
88Furrowed tongue (HP:0000221)2.08315920
89Facial hemangioma (HP:0000329)2.07361183
90Absent speech (HP:0001344)2.06889461
913-Methylglutaconic aciduria (HP:0003535)2.06062047
92Astrocytoma (HP:0009592)2.05830622
93Abnormality of the astrocytes (HP:0100707)2.05830622
94Ependymoma (HP:0002888)2.05799874
95Glioma (HP:0009733)2.04459145
96Prolonged neonatal jaundice (HP:0006579)2.01900537
97Autoamputation (HP:0001218)2.01704677
98Medial flaring of the eyebrow (HP:0010747)2.01447638
99Hamartoma of the eye (HP:0010568)2.01106699
100Thyroid-stimulating hormone excess (HP:0002925)2.00651390
101Hepatosplenomegaly (HP:0001433)1.97748881
102Aplasia/hypoplasia of the uterus (HP:0008684)1.96547566
103Slow saccadic eye movements (HP:0000514)1.96391946
104Anencephaly (HP:0002323)1.95437538
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95225455
106Broad-based gait (HP:0002136)1.94128424
107Erythroderma (HP:0001019)1.92820318
108Gastrointestinal atresia (HP:0002589)1.91991489
109Attenuation of retinal blood vessels (HP:0007843)1.90738126
110Nasolacrimal duct obstruction (HP:0000579)1.90381135
111Asplenia (HP:0001746)1.90273909
112Hyperglycinemia (HP:0002154)1.90007580
113Congenital hepatic fibrosis (HP:0002612)1.89529094
114Absent/shortened dynein arms (HP:0200106)1.88712259
115Dynein arm defect of respiratory motile cilia (HP:0012255)1.88712259
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87780506
117Partial duplication of thumb phalanx (HP:0009944)1.87217650
118Aplasia of the phalanges of the hand (HP:0009802)1.86763355
119Aplasia involving bones of the extremities (HP:0009825)1.86763355
120Aplasia involving bones of the upper limbs (HP:0009823)1.86763355
121Male pseudohermaphroditism (HP:0000037)1.86027514
122Duplication of thumb phalanx (HP:0009942)1.85453367
123Aganglionic megacolon (HP:0002251)1.85421767
124Abnormality of chromosome stability (HP:0003220)1.84957379
125Chronic hepatic failure (HP:0100626)1.84606871
126Secondary amenorrhea (HP:0000869)1.83749774
127Hepatocellular necrosis (HP:0001404)1.83564794
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.83392620
129Bile duct proliferation (HP:0001408)1.82357466
130Abnormal biliary tract physiology (HP:0012439)1.82357466
131Abnormality of the umbilical cord (HP:0010881)1.81408763
132Progressive inability to walk (HP:0002505)1.81003745
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.80941442
134Abnormality of the clitoris (HP:0000056)1.79632712
135Cerebral inclusion bodies (HP:0100314)1.79484856
136Pachygyria (HP:0001302)1.78971364
137Pendular nystagmus (HP:0012043)1.78611302
138Protruding tongue (HP:0010808)1.78519170
139Patellar aplasia (HP:0006443)1.78444221
140Premature ovarian failure (HP:0008209)1.77737774
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.77226344
142Hypoplasia of the fovea (HP:0007750)1.77226344
143Sclerocornea (HP:0000647)1.77219445
144Inability to walk (HP:0002540)1.76973492
145Anteriorly placed anus (HP:0001545)1.75908235
146Renal cortical cysts (HP:0000803)1.75547021
147Abnormality of the preputium (HP:0100587)1.75281052
148Premature skin wrinkling (HP:0100678)1.74678346
149Medulloblastoma (HP:0002885)1.74073041
150Anomalous pulmonary venous return (HP:0010772)1.73981169
151Hypergonadotropic hypogonadism (HP:0000815)1.73854612
152Hypoproteinemia (HP:0003075)1.73284692
153Stridor (HP:0010307)1.72628632
154Abnormal rod and cone electroretinograms (HP:0008323)1.72537032
155Mitochondrial inheritance (HP:0001427)1.70933096
156Abnormality of the salivary glands (HP:0010286)1.70930531
157Aplasia/Hypoplasia of the patella (HP:0006498)1.70134483
158Clitoromegaly (HP:0000057)1.69951670
159Absent hand (HP:0004050)1.69765898
160Increased CSF lactate (HP:0002490)1.68650054
161Stomatitis (HP:0010280)1.68539003
162Small hand (HP:0200055)1.68453742
163Lissencephaly (HP:0001339)1.68444458
164Abnormal respiratory motile cilium physiology (HP:0012261)1.67910145
165Clubbing of toes (HP:0100760)1.67527021
166Complete atrioventricular canal defect (HP:0001674)1.67453157
167Neoplasm of the oral cavity (HP:0100649)1.67347937
168Ectopic kidney (HP:0000086)1.67006039
169Vaginal atresia (HP:0000148)1.66494665
170Drooling (HP:0002307)1.66493093
171Chromsome breakage (HP:0040012)1.66039964
172Tubulointerstitial nephritis (HP:0001970)1.66020664
173Decreased lacrimation (HP:0000633)1.65960764
174Abnormal trabecular bone morphology (HP:0100671)1.65909349
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.65827086
176Genital tract atresia (HP:0001827)1.65431268
177Meningioma (HP:0002858)1.65144707
178Febrile seizures (HP:0002373)1.64979431
179Optic nerve hypoplasia (HP:0000609)1.63997611
180Methylmalonic aciduria (HP:0012120)1.63450765
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62296521
182Narrow forehead (HP:0000341)1.62099974
183Conjunctival hamartoma (HP:0100780)1.61183342
184Conical tooth (HP:0000698)1.61132061
185Small epiphyses (HP:0010585)1.60771854
186Neonatal death (HP:0003811)1.60236440
187Severe combined immunodeficiency (HP:0004430)1.60184153
188Rough bone trabeculation (HP:0100670)1.60093322
189Abnormal hair whorl (HP:0010721)1.59870682
190Hypophosphatemic rickets (HP:0004912)1.59837818
191Preaxial hand polydactyly (HP:0001177)1.59765647
192Fair hair (HP:0002286)1.59063150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.05339776
2FRK4.16738944
3NUAK13.89322919
4OXSR13.56760175
5TAF13.18092236
6PINK13.05825583
7PBK2.94259211
8WNK32.63025679
9BCR2.59788980
10MAP4K22.49461152
11EPHB12.43689292
12ERBB42.37939334
13TESK22.33193973
14DYRK22.28419003
15MAPKAPK52.11722174
16MAP3K42.10675904
17VRK22.08651248
18BUB12.05283155
19CDK191.96387490
20MUSK1.92412898
21BMPR1B1.92279750
22ADRBK21.89085329
23CSNK1G31.83063060
24PKN11.82803386
25GRK11.78636030
26MET1.75101249
27CCNB11.73399698
28MST41.72421751
29TTK1.71240296
30LIMK11.70639090
31TNIK1.70429671
32CSNK1A1L1.67518825
33NEK61.56016932
34CSNK1G11.52495430
35MAP2K71.50469215
36TRIM281.48715569
37PLK41.46753605
38MELK1.43001397
39MOS1.42820018
40ARAF1.39621673
41BRAF1.35443467
42WNK41.31078627
43MKNK11.29170589
44BMPR21.29155511
45PLK21.26715940
46ACVR1B1.20247514
47FGR1.18831838
48NTRK31.18812300
49TLK11.16029975
50WEE11.14798678
51INSRR1.13750304
52CSNK1G21.13192338
53CLK11.12646362
54TXK1.11758512
55FGFR21.06104741
56PNCK1.02910865
57VRK11.01430011
58MAP3K60.99714804
59CHEK20.99233235
60TRPM70.97616769
61PAK30.93615628
62GRK50.93468641
63STK100.93128270
64AURKA0.93019255
65ATR0.92932691
66NME10.89120274
67UHMK10.86879941
68RPS6KA50.85842197
69ERBB30.83680354
70ROCK20.83491797
71SRPK10.82774438
72DYRK30.82761312
73RPS6KA40.79636151
74CAMK2B0.77416991
75PAK60.77183944
76NTRK20.76387617
77PLK10.75911577
78STK160.75745969
79KIT0.74821204
80KSR20.73426599
81PAK10.73145435
82EPHA40.72909504
83TAOK30.72609351
84PRKCE0.71866233
85PRPF4B0.71832592
86EPHA30.71362956
87CDK70.70659341
88RAF10.69620712
89AKT30.68457405
90STK30.67582197
91MAPK130.65324876
92MAP3K130.65260588
93IRAK20.64803691
94CDK80.64709441
95SGK20.64014233
96PRKCG0.63143206
97NLK0.63122374
98MAP2K20.63104631
99ADRBK10.63041019
100EIF2AK10.62156828
101MARK10.61622087
102DYRK1A0.61525829
103CSNK1A10.61460770
104CDC70.61173092
105TYRO30.61106571
106MKNK20.61062658
107IRAK40.59316243
108CASK0.59245387
109SGK2230.57972670
110SGK4940.57972670
111CAMK2G0.57617639
112WNK10.57530325
113PLK30.56578497
114EIF2AK30.56576470
115CAMK2D0.56024084
116ABL20.54398633
117ICK0.53372989
118TEC0.52543642
119PIK3CA0.50540087
120CAMK1G0.49006434
121ATM0.48984724
122OBSCN0.47742404
123CDK30.47262017
124CSNK1D0.46979374
125LATS20.46484944
126STK110.44025217
127CHEK10.43085459
128TIE10.42969618
129BLK0.42726392
130CAMK2A0.42284325
131MAP2K40.40791300
132CAMKK20.38391450
133STK40.38363734
134CDK140.38179216
135NEK20.37299235
136PRKACA0.36762854
137MAP3K80.36735841
138PRKCQ0.36526309
139EIF2AK20.36493620
140LATS10.35895352
141ZAK0.35818872
142STK38L0.34447362
143CAMK10.34133376
144IRAK10.34053170
145ABL10.33740908
146BRD40.33553056
147GRK70.33365141
148CSNK1E0.32736644
149CDK10.32666324
150CDK150.32441675
151AURKB0.32271666
152BRSK20.31988637
153ERBB20.31769039
154MAPK150.31722186
155SYK0.31522837

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.90397311
2Steroid biosynthesis_Homo sapiens_hsa001003.62105223
3RNA polymerase_Homo sapiens_hsa030203.44521648
4Ether lipid metabolism_Homo sapiens_hsa005653.23220113
5Fatty acid elongation_Homo sapiens_hsa000623.09685217
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.08049278
7Basal transcription factors_Homo sapiens_hsa030223.01483899
8beta-Alanine metabolism_Homo sapiens_hsa004103.00318455
9Vitamin B6 metabolism_Homo sapiens_hsa007503.00303891
10Linoleic acid metabolism_Homo sapiens_hsa005912.25612072
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18805886
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15299119
13Proteasome_Homo sapiens_hsa030502.13760907
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01272696
15Sphingolipid metabolism_Homo sapiens_hsa006001.82432997
16RNA degradation_Homo sapiens_hsa030181.81705303
17Homologous recombination_Homo sapiens_hsa034401.79318442
18Nicotine addiction_Homo sapiens_hsa050331.71586816
19Cell cycle_Homo sapiens_hsa041101.70588172
20Phototransduction_Homo sapiens_hsa047441.67101700
21Protein export_Homo sapiens_hsa030601.65901847
22Mismatch repair_Homo sapiens_hsa034301.65755990
23Propanoate metabolism_Homo sapiens_hsa006401.47901134
24Fanconi anemia pathway_Homo sapiens_hsa034601.43438088
25DNA replication_Homo sapiens_hsa030301.41409599
26RNA transport_Homo sapiens_hsa030131.38208354
27Arachidonic acid metabolism_Homo sapiens_hsa005901.35397837
28Spliceosome_Homo sapiens_hsa030401.35026931
29Non-homologous end-joining_Homo sapiens_hsa034501.34689066
30Pyrimidine metabolism_Homo sapiens_hsa002401.34518810
31Nucleotide excision repair_Homo sapiens_hsa034201.33488283
32Butanoate metabolism_Homo sapiens_hsa006501.31493790
33Folate biosynthesis_Homo sapiens_hsa007901.24749475
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24498333
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23221502
36Regulation of autophagy_Homo sapiens_hsa041401.20876483
37Base excision repair_Homo sapiens_hsa034101.20633357
38Tryptophan metabolism_Homo sapiens_hsa003801.19984701
39Taste transduction_Homo sapiens_hsa047421.19725495
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19702518
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.14835913
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11079229
43Nitrogen metabolism_Homo sapiens_hsa009101.10685475
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09339624
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.07633906
46Glutathione metabolism_Homo sapiens_hsa004801.06622186
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02885519
48Caffeine metabolism_Homo sapiens_hsa002320.99532643
49Autoimmune thyroid disease_Homo sapiens_hsa053200.99221433
50Purine metabolism_Homo sapiens_hsa002300.98490496
51Oxidative phosphorylation_Homo sapiens_hsa001900.96722871
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94322453
53Rheumatoid arthritis_Homo sapiens_hsa053230.93294186
54Ovarian steroidogenesis_Homo sapiens_hsa049130.93224269
55One carbon pool by folate_Homo sapiens_hsa006700.92219599
56Peroxisome_Homo sapiens_hsa041460.92054117
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91071583
58Axon guidance_Homo sapiens_hsa043600.90039319
59Ribosome_Homo sapiens_hsa030100.89943833
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89900136
61Asthma_Homo sapiens_hsa053100.89275720
62Graft-versus-host disease_Homo sapiens_hsa053320.87935239
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85683061
64Arginine and proline metabolism_Homo sapiens_hsa003300.85675015
65Selenocompound metabolism_Homo sapiens_hsa004500.82000088
66Histidine metabolism_Homo sapiens_hsa003400.81868048
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.81482460
68TGF-beta signaling pathway_Homo sapiens_hsa043500.79576766
69Allograft rejection_Homo sapiens_hsa053300.79574129
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78468219
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78205535
72Oocyte meiosis_Homo sapiens_hsa041140.76158709
73Renal cell carcinoma_Homo sapiens_hsa052110.75699347
74mRNA surveillance pathway_Homo sapiens_hsa030150.75650497
75Insulin secretion_Homo sapiens_hsa049110.74245297
76Circadian entrainment_Homo sapiens_hsa047130.71876752
77Primary immunodeficiency_Homo sapiens_hsa053400.71760094
78Olfactory transduction_Homo sapiens_hsa047400.71698857
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71593277
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70830594
81Glutamatergic synapse_Homo sapiens_hsa047240.70569966
82Sulfur metabolism_Homo sapiens_hsa009200.69998331
83Morphine addiction_Homo sapiens_hsa050320.69974073
84Malaria_Homo sapiens_hsa051440.65599394
85Renin secretion_Homo sapiens_hsa049240.63392361
86Chemical carcinogenesis_Homo sapiens_hsa052040.63256317
87GABAergic synapse_Homo sapiens_hsa047270.62750593
88Tight junction_Homo sapiens_hsa045300.62194118
89ABC transporters_Homo sapiens_hsa020100.61300585
90Huntingtons disease_Homo sapiens_hsa050160.59688575
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.59249360
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58022645
93Phagosome_Homo sapiens_hsa041450.57001200
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55574140
95Glycerolipid metabolism_Homo sapiens_hsa005610.53512706
96Systemic lupus erythematosus_Homo sapiens_hsa053220.52306915
97Epstein-Barr virus infection_Homo sapiens_hsa051690.50550108
98p53 signaling pathway_Homo sapiens_hsa041150.48451570
99Fatty acid degradation_Homo sapiens_hsa000710.47428264
100Calcium signaling pathway_Homo sapiens_hsa040200.46723912
101Cardiac muscle contraction_Homo sapiens_hsa042600.46490605
102Parkinsons disease_Homo sapiens_hsa050120.46176232
103Ras signaling pathway_Homo sapiens_hsa040140.45979658
104Salivary secretion_Homo sapiens_hsa049700.45899279
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45514169
106Hippo signaling pathway_Homo sapiens_hsa043900.43224200
107Serotonergic synapse_Homo sapiens_hsa047260.42250846
108Dopaminergic synapse_Homo sapiens_hsa047280.42101880
109Notch signaling pathway_Homo sapiens_hsa043300.42090084
110Type I diabetes mellitus_Homo sapiens_hsa049400.41685679
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41647874
112Metabolic pathways_Homo sapiens_hsa011000.41610078
113Gastric acid secretion_Homo sapiens_hsa049710.41037194
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40957387
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40750498
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.40501778
117Shigellosis_Homo sapiens_hsa051310.38258082
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37927994
119Salmonella infection_Homo sapiens_hsa051320.37007734
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36401183
121Circadian rhythm_Homo sapiens_hsa047100.36014433
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35860083
123Basal cell carcinoma_Homo sapiens_hsa052170.34774270
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34005695
125Hedgehog signaling pathway_Homo sapiens_hsa043400.33741580
126Choline metabolism in cancer_Homo sapiens_hsa052310.33247840
127Dorso-ventral axis formation_Homo sapiens_hsa043200.32992704
128MicroRNAs in cancer_Homo sapiens_hsa052060.32983295
129Alzheimers disease_Homo sapiens_hsa050100.32506610
130Endocytosis_Homo sapiens_hsa041440.31315822
131Cholinergic synapse_Homo sapiens_hsa047250.31185669
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31106878
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.31037737
134Long-term depression_Homo sapiens_hsa047300.30658976
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30443267
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30109719
137Hematopoietic cell lineage_Homo sapiens_hsa046400.29274667
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25204933
139Oxytocin signaling pathway_Homo sapiens_hsa049210.25196192
140Collecting duct acid secretion_Homo sapiens_hsa049660.24900915
141Retinol metabolism_Homo sapiens_hsa008300.24486428
142Other glycan degradation_Homo sapiens_hsa005110.22376576
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.22324761
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21428308
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20568228
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.20492404
147Vitamin digestion and absorption_Homo sapiens_hsa049770.19696907
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18246600
149Herpes simplex infection_Homo sapiens_hsa051680.18097773

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