TRIM15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)6.61426291
2negative regulation of hormone biosynthetic process (GO:0032353)6.50393776
3negative regulation of hormone metabolic process (GO:0032351)6.50393776
4hemidesmosome assembly (GO:0031581)6.13895072
5plasma lipoprotein particle assembly (GO:0034377)6.12872280
6intestinal absorption (GO:0050892)5.78837127
7low-density lipoprotein particle remodeling (GO:0034374)5.76053993
8regulation of bile acid biosynthetic process (GO:0070857)5.75608265
9regulation of cholesterol esterification (GO:0010872)5.68353467
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66245723
11maintenance of gastrointestinal epithelium (GO:0030277)5.62577930
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.55579030
13protein-lipid complex assembly (GO:0065005)5.51241402
14macromolecular complex remodeling (GO:0034367)5.45600547
15plasma lipoprotein particle remodeling (GO:0034369)5.45600547
16protein-lipid complex remodeling (GO:0034368)5.45600547
17regulation of glucocorticoid metabolic process (GO:0031943)5.45409646
18high-density lipoprotein particle remodeling (GO:0034375)5.31900311
19intestinal cholesterol absorption (GO:0030299)5.02397666
20plasma lipoprotein particle organization (GO:0071827)5.00504536
21epoxygenase P450 pathway (GO:0019373)4.91007399
22negative regulation of fibrinolysis (GO:0051918)4.90385019
23reverse cholesterol transport (GO:0043691)4.87264006
24protein-lipid complex subunit organization (GO:0071825)4.73697859
25urea metabolic process (GO:0019627)4.72378046
26cholesterol efflux (GO:0033344)4.72018712
27urea cycle (GO:0000050)4.71646111
28peptidyl-glutamic acid carboxylation (GO:0017187)4.70084354
29protein carboxylation (GO:0018214)4.70084354
30regulation of meiosis I (GO:0060631)4.69999517
31regulation of protein activation cascade (GO:2000257)4.69131160
32regulation of cholesterol homeostasis (GO:2000188)4.60747284
33phospholipid efflux (GO:0033700)4.60361774
34regulation of meiosis (GO:0040020)4.59754373
35regulation of complement activation (GO:0030449)4.57690542
36epithelial structure maintenance (GO:0010669)4.55595071
37fat-soluble vitamin biosynthetic process (GO:0042362)4.49888732
38intestinal epithelial cell development (GO:0060576)4.46222814
39angiotensin maturation (GO:0002003)4.42997137
40proline metabolic process (GO:0006560)4.40992784
41cellular glucuronidation (GO:0052695)4.40604737
42positive regulation of triglyceride lipase activity (GO:0061365)4.39221039
43positive regulation of lipoprotein lipase activity (GO:0051006)4.39221039
44regulation of fibrinolysis (GO:0051917)4.38326844
45NADH metabolic process (GO:0006734)4.37439802
46nitrogen cycle metabolic process (GO:0071941)4.36024988
47regulation of transforming growth factor beta2 production (GO:0032909)4.34310237
48regulation of female gonad development (GO:2000194)4.32379554
49negative regulation of cholesterol transport (GO:0032375)4.28189384
50negative regulation of sterol transport (GO:0032372)4.28189384
51lipoprotein metabolic process (GO:0042157)4.22938799
52uronic acid metabolic process (GO:0006063)4.22746512
53glucuronate metabolic process (GO:0019585)4.22746512
54blood coagulation, intrinsic pathway (GO:0007597)4.11509727
55lipoprotein transport (GO:0042953)4.11363571
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.08861856
57L-phenylalanine metabolic process (GO:0006558)4.08861856
58regulation of steroid hormone biosynthetic process (GO:0090030)4.08007035
59bile acid and bile salt transport (GO:0015721)4.06922110
60arginine metabolic process (GO:0006525)4.06695989
61positive regulation of megakaryocyte differentiation (GO:0045654)4.05920203
62positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.04244875
63regulation of triglyceride catabolic process (GO:0010896)4.03556899
64L-phenylalanine catabolic process (GO:0006559)4.02371098
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02371098
66flavonoid metabolic process (GO:0009812)3.95527748
67ethanol oxidation (GO:0006069)3.94257831
68complement activation, classical pathway (GO:0006958)3.90546081
69regulation of guanylate cyclase activity (GO:0031282)3.89898696
70cholesterol homeostasis (GO:0042632)3.89499023
71regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.88015234
72endocrine process (GO:0050886)3.88015234
73regulation of systemic arterial blood pressure by hormone (GO:0001990)3.88015234
74piRNA metabolic process (GO:0034587)3.87963041
75sterol homeostasis (GO:0055092)3.83142664
76drug catabolic process (GO:0042737)3.83136710
77renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.81072298
78glutamine family amino acid biosynthetic process (GO:0009084)3.80382474
79drug metabolic process (GO:0017144)3.76617288
80plasma lipoprotein particle clearance (GO:0034381)3.74346399
81diterpenoid biosynthetic process (GO:0016102)3.72893944
82proline biosynthetic process (GO:0006561)3.71896157
83positive regulation of fatty acid biosynthetic process (GO:0045723)3.70611983
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65379672
85positive regulation of Cdc42 GTPase activity (GO:0043089)3.62269905
86interferon-gamma secretion (GO:0072643)3.61033204
87tight junction assembly (GO:0070830)3.60830740
88columnar/cuboidal epithelial cell development (GO:0002066)3.60156330
89complement activation, alternative pathway (GO:0006957)3.59735821
90regulation of meiotic cell cycle (GO:0051445)3.59696211
91hepatocyte apoptotic process (GO:0097284)3.59433691
92protein activation cascade (GO:0072376)3.58482399
93negative regulation of blood coagulation (GO:0030195)3.56758182
94negative regulation of hemostasis (GO:1900047)3.56758182
95bile acid metabolic process (GO:0008206)3.55964119
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.54820661
97digestive system process (GO:0022600)3.53431395
98regulation of endothelial cell differentiation (GO:0045601)3.52970033
99thyroid hormone metabolic process (GO:0042403)3.52421098
100glycerophospholipid catabolic process (GO:0046475)3.51524795
101regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.50140604
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50074305
103actin filament depolymerization (GO:0030042)3.49442533
104O-glycan processing (GO:0016266)3.47984581
105fructose metabolic process (GO:0006000)3.46770496
106regulation of sister chromatid cohesion (GO:0007063)3.45120717
107negative regulation of smooth muscle cell differentiation (GO:0051151)3.44880579
108regulation of proton transport (GO:0010155)3.44489220
109cGMP-mediated signaling (GO:0019934)3.43836795
110regulation of hormone metabolic process (GO:0032350)3.42823286
111parturition (GO:0007567)3.38735553
112positive regulation of lipid catabolic process (GO:0050996)3.38607537
113regulation of apoptotic cell clearance (GO:2000425)3.38138382
114antibacterial humoral response (GO:0019731)3.37532636
115DNA damage induced protein phosphorylation (GO:0006975)3.37160194
116type B pancreatic cell development (GO:0003323)3.37094264
117sulfate transmembrane transport (GO:1902358)3.37064278
118triglyceride homeostasis (GO:0070328)3.36627761
119acylglycerol homeostasis (GO:0055090)3.36627761
120negative regulation of meiosis (GO:0045835)3.36032498
121myoblast migration (GO:0051451)3.35865408
122inner cell mass cell proliferation (GO:0001833)3.34246054
123DNA damage response, signal transduction resulting in transcription (GO:0042772)3.33322722
124regulation of cholesterol metabolic process (GO:0090181)3.31829599
125acute-phase response (GO:0006953)3.31175617
126negative regulation of coagulation (GO:0050819)3.30190568
127antimicrobial humoral response (GO:0019730)3.29970119
128regulation of systemic arterial blood pressure (GO:0003073)3.29747352
129male genitalia development (GO:0030539)3.28362797
130complement activation (GO:0006956)3.27988162
131negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.27531961
132positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.25773821
133negative regulation of steroid biosynthetic process (GO:0010894)3.22637001
134regulation of plasminogen activation (GO:0010755)3.22161118
135hormone catabolic process (GO:0042447)3.21761569
136transcytosis (GO:0045056)3.20596266
137fibrinolysis (GO:0042730)3.19773334
138exogenous drug catabolic process (GO:0042738)3.19409219
139drug transmembrane transport (GO:0006855)3.19109916
140renal system process involved in regulation of blood volume (GO:0001977)3.18619935
141ethanol metabolic process (GO:0006067)3.18587887
142regulation of histone H3-K27 methylation (GO:0061085)3.18012646
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.16242690
144regulation of hormone biosynthetic process (GO:0046885)3.15006582
145sterol transport (GO:0015918)3.12151397
146cholesterol transport (GO:0030301)3.12151397
147notochord development (GO:0030903)3.11951685
148oocyte maturation (GO:0001556)3.10527664
149vitamin A metabolic process (GO:0006776)3.10411766
150positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.08317392
151negative regulation of keratinocyte proliferation (GO:0010839)3.07776357
152righting reflex (GO:0060013)3.07413731
153positive regulation of actin filament depolymerization (GO:0030836)3.06625140
154UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06353643
155negative regulation of wound healing (GO:0061045)3.05665386
156positive regulation of steroid metabolic process (GO:0045940)3.05374037
157regulation of cardioblast differentiation (GO:0051890)3.05043861
158phosphatidylinositol acyl-chain remodeling (GO:0036149)3.02439318
159lipid homeostasis (GO:0055088)3.01899149
160negative regulation of protein activation cascade (GO:2000258)3.01395073
161regulation of Cdc42 GTPase activity (GO:0043088)3.00692860
162phospholipid homeostasis (GO:0055091)3.00536122
163vitamin transmembrane transport (GO:0035461)3.00196438
164positive regulation of neurological system process (GO:0031646)2.96937395
165female gamete generation (GO:0007292)2.96697980
166negative regulation of steroid metabolic process (GO:0045939)2.96023142
167citrulline biosynthetic process (GO:0019240)2.94574984
168diol metabolic process (GO:0034311)2.92037692
169positive regulation of protein localization to plasma membrane (GO:1903078)2.90149567
170defense response to Gram-negative bacterium (GO:0050829)2.90064922
171sphingosine metabolic process (GO:0006670)2.85356294
172regulation of retinoic acid receptor signaling pathway (GO:0048385)2.83544440
173regulation of mononuclear cell migration (GO:0071675)2.83435919
174ventricular cardiac muscle cell action potential (GO:0086005)2.82758839
175regulation of exit from mitosis (GO:0007096)2.81757335
176mitochondrial calcium ion transport (GO:0006851)2.81502588
177mesodermal cell differentiation (GO:0048333)2.80936289
178filopodium assembly (GO:0046847)2.78209680
179negative regulation of homotypic cell-cell adhesion (GO:0034111)2.77363605
180fucose catabolic process (GO:0019317)2.73907875
181L-fucose metabolic process (GO:0042354)2.73907875
182L-fucose catabolic process (GO:0042355)2.73907875
183sulfate transport (GO:0008272)2.73069140
184regulation of cytokine secretion involved in immune response (GO:0002739)2.71690061
185calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.70114900
186regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69936083
187positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67846246
188detection of bacterium (GO:0016045)2.67635702
189regulation of germinal center formation (GO:0002634)2.64841297
190phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64070267
191positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.63657191
192diacylglycerol metabolic process (GO:0046339)2.63070321
193membrane budding (GO:0006900)2.62947887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.71426977
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.36764781
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.77644225
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.26694542
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.19612268
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.99188130
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.91748627
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.77620816
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.66206487
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.07273781
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.91724226
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.91119138
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.44540527
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40822966
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38510012
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38139794
17* HNF4A_19822575_ChIP-Seq_HepG2_Human2.28578840
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.26566388
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21787578
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.17289598
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13158294
22KAP1_22055183_ChIP-Seq_ESCs_Mouse2.12508153
23ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09903916
24SOX2_20726797_ChIP-Seq_SW620_Human2.05740211
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.02161970
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01710796
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00578527
28GATA4_25053715_ChIP-Seq_YYC3_Human1.93344757
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.89106652
30GATA6_25053715_ChIP-Seq_YYC3_Human1.86053394
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80973836
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80599195
33LXR_22292898_ChIP-Seq_THP-1_Human1.80026109
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79282881
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.77391084
36KLF5_25053715_ChIP-Seq_YYC3_Human1.73082375
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67782910
38CLOCK_20551151_ChIP-Seq_293T_Human1.66613687
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60417928
40AR_21909140_ChIP-Seq_LNCAP_Human1.59473492
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58370327
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52478230
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49957472
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.48369868
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47341053
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.46798839
47CDX2_22108803_ChIP-Seq_LS180_Human1.46774020
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.46692685
49VDR_22108803_ChIP-Seq_LS180_Human1.43740602
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42142198
51GATA1_19941826_ChIP-Seq_K562_Human1.41568923
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39320718
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.38157786
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.37684545
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36626495
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.35563592
57ATF3_27146783_Chip-Seq_COLON_Human1.35306258
58CJUN_26792858_Chip-Seq_BT549_Human1.32552296
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31598326
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31488748
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29792569
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29034664
63* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27959161
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27727549
65RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26301616
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.25916423
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25651866
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25509387
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25248104
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23782914
71GATA1_22025678_ChIP-Seq_K562_Human1.23539964
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20753259
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20649135
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20389578
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18601662
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17445511
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16822326
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.16495607
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.16370272
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16294637
81BCOR_27268052_Chip-Seq_Bcells_Human1.12345168
82STAT1_17558387_ChIP-Seq_HELA_Human1.11881123
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.09840763
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08917114
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08860364
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08856571
87TP63_23658742_ChIP-Seq_EP156T_Human1.08785339
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08644091
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08489128
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07250349
91CEBPB_22108803_ChIP-Seq_LS180_Human1.06175622
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05854361
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05416177
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03762645
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03447971
96BCL6_27268052_Chip-Seq_Bcells_Human1.02964439
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02957107
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02103659
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02044990
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01082259
101ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00493640
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99964595
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99964595
104* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99782890
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99711329
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.99319178
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98490383
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98390063
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98245113
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97823476
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95268400
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94787500
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.93109098
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93028732
115* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91916029
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.91898638
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91669040
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.88973546
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88314447
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88109578
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87634008
122E2F1_20622854_ChIP-Seq_HELA_Human0.85797316
123* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85516009
124SA1_27219007_Chip-Seq_Bcells_Human0.85431412
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84939454
126AHR_22903824_ChIP-Seq_MCF-7_Human0.84838387
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84672680
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.84661280
129GATA2_19941826_ChIP-Seq_K562_Human0.84452255
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84147057
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83822797
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83743490
133P68_20966046_ChIP-Seq_HELA_Human0.83162298
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82851510
135RACK7_27058665_Chip-Seq_MCF-7_Human0.82374277
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82044099
137VDR_24787735_ChIP-Seq_THP-1_Human0.81109241
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81099837
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80694655
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80546473
141STAT3_23295773_ChIP-Seq_U87_Human0.79390863
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79311729
143BCAT_22108803_ChIP-Seq_LS180_Human0.78995510
144SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78947340
145PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78474688
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78232200
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.77553978
148CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77468738
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77384165
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77096676
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77058913
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77030374
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76436501
154ZNF263_19887448_ChIP-Seq_K562_Human0.76373331
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75801430
156SOX2_21211035_ChIP-Seq_LN229_Human0.75801064
157TRIM28_21343339_ChIP-Seq_HEK293_Human0.75717715
158LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75309560
159SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74732899
160NFYA_21822215_ChIP-Seq_K562_Human0.74451852
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73744148
162KDM2B_26808549_Chip-Seq_REH_Human0.73111608
163TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.72595021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.79130051
2MP0005365_abnormal_bile_salt5.07049047
3MP0005360_urolithiasis5.03865951
4MP0005451_abnormal_body_composition4.38291152
5MP0004264_abnormal_extraembryonic_tissu4.32909261
6MP0000462_abnormal_digestive_system4.12408534
7MP0002102_abnormal_ear_morphology3.80871436
8MP0001666_abnormal_nutrient_absorption3.15629666
9MP0003718_maternal_effect3.15225581
10MP0003646_muscle_fatigue2.81217522
11MP0003868_abnormal_feces_composition2.48168738
12MP0001849_ear_inflammation2.39185801
13MP0002653_abnormal_ependyma_morphology2.34509460
14MP0003195_calcinosis2.25163816
15MP0010368_abnormal_lymphatic_system2.20200383
16MP0005332_abnormal_amino_acid2.09980519
17MP0000538_abnormal_urinary_bladder2.02922485
18MP0006054_spinal_hemorrhage1.98326954
19MP0003693_abnormal_embryo_hatching1.86260579
20MP0000537_abnormal_urethra_morphology1.84853028
21MP0009840_abnormal_foam_cell1.81657080
22MP0005381_digestive/alimentary_phenotyp1.78452504
23MP0003866_abnormal_defecation1.78244490
24MP0002139_abnormal_hepatobiliary_system1.77808959
25MP0005409_darkened_coat_color1.72241702
26MP0005464_abnormal_platelet_physiology1.69822055
27MP0000609_abnormal_liver_physiology1.68350905
28MP0003252_abnormal_bile_duct1.67738212
29MP0002118_abnormal_lipid_homeostasis1.66673818
30MP0010678_abnormal_skin_adnexa1.63242060
31MP0009643_abnormal_urine_homeostasis1.63000360
32MP0002876_abnormal_thyroid_physiology1.61767013
33MP0004782_abnormal_surfactant_physiolog1.60712452
34MP0005636_abnormal_mineral_homeostasis1.57517717
35MP0000490_abnormal_crypts_of1.55678383
36MP0005058_abnormal_lysosome_morphology1.53360997
37MP0010155_abnormal_intestine_physiology1.52653452
38MP0000566_synostosis1.50555691
39MP0001764_abnormal_homeostasis1.49690702
40MP0002249_abnormal_larynx_morphology1.47736369
41MP0003806_abnormal_nucleotide_metabolis1.43119617
42MP0003453_abnormal_keratinocyte_physiol1.41823717
43MP0009379_abnormal_foot_pigmentation1.41780520
44MP0005085_abnormal_gallbladder_physiolo1.41386738
45MP0003879_abnormal_hair_cell1.39889006
46MP0005395_other_phenotype1.39746850
47MP0005187_abnormal_penis_morphology1.38749419
48MP0005408_hypopigmentation1.38129309
49MP0000477_abnormal_intestine_morphology1.32786116
50MP0001663_abnormal_digestive_system1.30883493
51MP0003699_abnormal_female_reproductive1.27627741
52MP0000579_abnormal_nail_morphology1.24857726
53MP0003123_paternal_imprinting1.23190295
54MP0005310_abnormal_salivary_gland1.22065416
55MP0005167_abnormal_blood-brain_barrier1.17962624
56MP0001984_abnormal_olfaction1.15763020
57MP0005670_abnormal_white_adipose1.15668330
58MP0004043_abnormal_pH_regulation1.15630963
59MP0002796_impaired_skin_barrier1.15082462
60MP0003191_abnormal_cellular_cholesterol1.14618012
61MP0001119_abnormal_female_reproductive1.14467756
62MP0003329_amyloid_beta_deposits1.13919903
63MP0002089_abnormal_postnatal_growth/wei1.13868312
64MP0003315_abnormal_perineum_morphology1.13832932
65MP0001664_abnormal_digestion1.13812521
66MP0005319_abnormal_enzyme/_coenzyme1.12500332
67MP0000427_abnormal_hair_cycle1.12074134
68MP0000613_abnormal_salivary_gland1.10978629
69MP0005248_abnormal_Harderian_gland1.08849921
70MP0005084_abnormal_gallbladder_morpholo1.00917026
71MP0008875_abnormal_xenobiotic_pharmacok1.00020204
72MP0001765_abnormal_ion_homeostasis0.99757201
73MP0004957_abnormal_blastocyst_morpholog0.99054579
74MP0001756_abnormal_urination0.98843837
75MP0002136_abnormal_kidney_physiology0.96907798
76MP0009642_abnormal_blood_homeostasis0.96170170
77MP0003183_abnormal_peptide_metabolism0.95874744
78MP0001873_stomach_inflammation0.95664423
79MP0003937_abnormal_limbs/digits/tail_de0.95445988
80MP0004270_analgesia0.95240474
81MP0003656_abnormal_erythrocyte_physiolo0.92874005
82MP0009697_abnormal_copulation0.92541753
83MP0003300_gastrointestinal_ulcer0.92344636
84MP0005584_abnormal_enzyme/coenzyme_acti0.91883255
85MP0003938_abnormal_ear_development0.91404635
86MP0005166_decreased_susceptibility_to0.91380606
87MP0001216_abnormal_epidermal_layer0.91346952
88MP0005501_abnormal_skin_physiology0.90840223
89MP0003566_abnormal_cell_adhesion0.89777624
90MP0004185_abnormal_adipocyte_glucose0.89426564
91MP0005083_abnormal_biliary_tract0.87781832
92MP0002132_abnormal_respiratory_system0.87183850
93MP0001881_abnormal_mammary_gland0.86683428
94MP0003091_abnormal_cell_migration0.85028154
95MP0009384_cardiac_valve_regurgitation0.84718251
96MP0000678_abnormal_parathyroid_gland0.83648014
97MP0003705_abnormal_hypodermis_morpholog0.82929051
98MP0004947_skin_inflammation0.82839000
99MP0005448_abnormal_energy_balance0.82702609
100MP0003172_abnormal_lysosome_physiology0.82697601
101MP0000598_abnormal_liver_morphology0.82272569
102MP0000653_abnormal_sex_gland0.81601963
103MP0002877_abnormal_melanocyte_morpholog0.80869433
104MP0002254_reproductive_system_inflammat0.78123932
105MP0005023_abnormal_wound_healing0.77454052
106MP0003122_maternal_imprinting0.77411164
107MP0001851_eye_inflammation0.77261273
108MP0002234_abnormal_pharynx_morphology0.77149903
109MP0004858_abnormal_nervous_system0.76942552
110MP0002971_abnormal_brown_adipose0.75421247
111MP0004484_altered_response_of0.73668174
112MP0001879_abnormal_lymphatic_vessel0.73291322
113MP0002098_abnormal_vibrissa_morphology0.72637792
114MP0008469_abnormal_protein_level0.71656075
115MP0003950_abnormal_plasma_membrane0.70166456
116MP0002166_altered_tumor_susceptibility0.70005051
117MP0000639_abnormal_adrenal_gland0.68391809
118MP0002734_abnormal_mechanical_nocicepti0.68095993
119MP0001915_intracranial_hemorrhage0.67482849
120MP0008872_abnormal_physiological_respon0.67191246
121MP0002138_abnormal_hepatobiliary_system0.67181969
122MP0000249_abnormal_blood_vessel0.66891728
123MP0003045_fibrosis0.66726285
124MP0000604_amyloidosis0.65157356
125MP0004147_increased_porphyrin_level0.64784453
126MP0003638_abnormal_response/metabolism_0.63647813
127MP0002060_abnormal_skin_morphology0.62926301
128MP0009115_abnormal_fat_cell0.62643281
129MP0008789_abnormal_olfactory_epithelium0.62329437
130MP0000343_altered_response_to0.62016856
131MP0003436_decreased_susceptibility_to0.61771196
132MP0001845_abnormal_inflammatory_respons0.61652629
133MP0000762_abnormal_tongue_morphology0.61094860
134MP0000627_abnormal_mammary_gland0.59995856
135MP0000470_abnormal_stomach_morphology0.59566908
136MP0003878_abnormal_ear_physiology0.59392525
137MP0005377_hearing/vestibular/ear_phenot0.59392525
138MP0002078_abnormal_glucose_homeostasis0.59371511
139MP0010352_gastrointestinal_tract_polyps0.58842251
140MP0005666_abnormal_adipose_tissue0.58356076
141MP0000858_altered_metastatic_potential0.58244663
142MP0010329_abnormal_lipoprotein_level0.57884504
143MP0000534_abnormal_ureter_morphology0.56382264
144MP0004019_abnormal_vitamin_homeostasis0.56247342
145MP0009333_abnormal_splenocyte_physiolog0.55501627
146MP0003953_abnormal_hormone_level0.54279655
147MP0001929_abnormal_gametogenesis0.52291859
148MP0008004_abnormal_stomach_pH0.50769231
149MP0009785_altered_susceptibility_to0.48894478
150MP0005410_abnormal_fertilization0.46831945
151MP0005257_abnormal_intraocular_pressure0.46469245
152MP0000465_gastrointestinal_hemorrhage0.45809659
153MP0000230_abnormal_systemic_arterial0.45032086
154MP0009780_abnormal_chondrocyte_physiolo0.44902500
155MP0005376_homeostasis/metabolism_phenot0.44663111
156MP0009763_increased_sensitivity_to0.44638129
157MP0001661_extended_life_span0.43236912

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.03189033
2Deep venous thrombosis (HP:0002625)6.69684178
3Milia (HP:0001056)6.00669998
4Right ventricular cardiomyopathy (HP:0011663)5.65657161
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.32009905
6Systemic lupus erythematosus (HP:0002725)5.15896499
7Atrophic scars (HP:0001075)5.15555781
8Fragile nails (HP:0001808)5.12020233
9Xanthomatosis (HP:0000991)4.97179379
10Complement deficiency (HP:0004431)4.84599343
11Hemorrhage of the eye (HP:0011885)4.75061925
12Male infertility (HP:0003251)4.71577044
13Prolonged partial thromboplastin time (HP:0003645)4.60060422
14Joint hemorrhage (HP:0005261)4.15363829
15Abnormality of complement system (HP:0005339)4.13546918
16Ileus (HP:0002595)4.13181737
17Glomerulonephritis (HP:0000099)4.05745290
18Malnutrition (HP:0004395)3.94084372
19Acanthocytosis (HP:0001927)3.69753611
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68305901
21Pustule (HP:0200039)3.58151200
22Menorrhagia (HP:0000132)3.52529683
23Vascular tortuosity (HP:0004948)3.44115585
24Purpura (HP:0000979)3.42479906
25Arterial tortuosity (HP:0005116)3.34719698
26Goiter (HP:0000853)3.33892922
27Adrenal hypoplasia (HP:0000835)3.31482139
28Abnormality of the common coagulation pathway (HP:0010990)3.30693259
29Widely patent fontanelles and sutures (HP:0004492)3.30231572
30Flat acetabular roof (HP:0003180)3.23520776
31Autoimmune thrombocytopenia (HP:0001973)3.22423685
32Curly hair (HP:0002212)3.17517026
33Plantar hyperkeratosis (HP:0007556)3.11871114
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06262158
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.03225191
36Abnormality of small intestinal villus morphology (HP:0011472)3.00874948
37Villous atrophy (HP:0011473)3.00874948
38Spontaneous abortion (HP:0005268)2.96190891
39Hyperlipoproteinemia (HP:0010980)2.96130574
40Abnormal tarsal ossification (HP:0008369)2.95298841
41Hypercholesterolemia (HP:0003124)2.89401175
42Shawl scrotum (HP:0000049)2.88476384
43Poikilocytosis (HP:0004447)2.88269528
44Hyperglycinuria (HP:0003108)2.87431081
45Gingival bleeding (HP:0000225)2.85149079
46Micronodular cirrhosis (HP:0001413)2.84355380
47Hypoplasia of dental enamel (HP:0006297)2.83672634
48Dehydration (HP:0001944)2.80627991
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79639063
50Hyperammonemia (HP:0001987)2.76802386
51Nephritis (HP:0000123)2.76385887
52Ureteral stenosis (HP:0000071)2.75341367
53Abnormality of glycine metabolism (HP:0010895)2.75236151
54Abnormality of serine family amino acid metabolism (HP:0010894)2.75236151
55Pili torti (HP:0003777)2.72138377
56Vascular calcification (HP:0004934)2.71925351
57Hyperactive renin-angiotensin system (HP:0000841)2.68670954
58Lip pit (HP:0100267)2.67942414
59Generalized aminoaciduria (HP:0002909)2.65419985
60Abnormality of urine glucose concentration (HP:0011016)2.65411981
61Glycosuria (HP:0003076)2.65411981
62Proximal tubulopathy (HP:0000114)2.64711918
63Epidermoid cyst (HP:0200040)2.63675610
64Ureteral obstruction (HP:0006000)2.62510167
65Abnormality of carpal bone ossification (HP:0006257)2.62434726
66Flat capital femoral epiphysis (HP:0003370)2.61843200
67Nausea (HP:0002018)2.60799099
68Congenital sensorineural hearing impairment (HP:0008527)2.56982738
69Chronic bronchitis (HP:0004469)2.56419322
70Breast hypoplasia (HP:0003187)2.56373748
71Abnormality of the fingertips (HP:0001211)2.55504426
72Alkalosis (HP:0001948)2.55118472
73Abnormality of proline metabolism (HP:0010907)2.54378703
74Hydroxyprolinuria (HP:0003080)2.54378703
75Abnormality of pyrimidine metabolism (HP:0004353)2.52907082
76Cupped ribs (HP:0000887)2.49168456
77Breast aplasia (HP:0100783)2.46837285
78Cortical dysplasia (HP:0002539)2.45812389
79Hypobetalipoproteinemia (HP:0003563)2.45383756
80Hypophosphatemic rickets (HP:0004912)2.42641254
81Nail dystrophy (HP:0008404)2.42058682
82Aplasia/Hypoplasia of the breasts (HP:0010311)2.41640097
83Subacute progressive viral hepatitis (HP:0006572)2.40237875
84Abnormality of vitamin metabolism (HP:0100508)2.38231009
85Wide cranial sutures (HP:0010537)2.37008117
86Rickets (HP:0002748)2.36219074
87Abnormality of the 1st metacarpal (HP:0010009)2.33230478
88Prostate neoplasm (HP:0100787)2.32254510
89Abnormality of the vitamin B12 metabolism (HP:0004341)2.30424600
90Syncope (HP:0001279)2.30025551
91Cardiovascular calcification (HP:0011915)2.29757646
92Metabolic alkalosis (HP:0200114)2.28787718
93Hepatocellular carcinoma (HP:0001402)2.28675324
94Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.21551660
95Hypotension (HP:0002615)2.21020498
96Glomerulosclerosis (HP:0000096)2.20661375
97Abnormality of nucleobase metabolism (HP:0010932)2.20134626
98Prolonged bleeding time (HP:0003010)2.19987517
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.19838049
100Steatorrhea (HP:0002570)2.19397100
101Potter facies (HP:0002009)2.18094330
102Facial shape deformation (HP:0011334)2.18094330
103Abnormal blistering of the skin (HP:0008066)2.15413764
104Epistaxis (HP:0000421)2.11779349
105Intrahepatic cholestasis (HP:0001406)2.11622198
106Hypophosphatemia (HP:0002148)2.11304073
107Gout (HP:0001997)2.11019273
108Short nail (HP:0001799)2.10541246
109Abnormality of vitamin B metabolism (HP:0004340)2.09894899
110Hypoglycemic coma (HP:0001325)2.09689489
111Petechiae (HP:0000967)2.08899286
112Decreased circulating renin level (HP:0003351)2.08069237
113Focal segmental glomerulosclerosis (HP:0000097)2.07200740
114Increased mean platelet volume (HP:0011877)2.06683640
115Abnormality of the gastric mucosa (HP:0004295)2.05898525
116Capillary hemangiomas (HP:0005306)2.05870764
117Abnormality of the phalanges of the hallux (HP:0010057)2.05798756
118Thin bony cortex (HP:0002753)2.04808524
119Abdominal distention (HP:0003270)2.04088287
120Abnormal foot bone ossification (HP:0010675)2.03304784
121Abnormality of the proximal phalanges of the hand (HP:0009834)2.00896709
122Confusion (HP:0001289)1.99601579
123Abnormality of renin-angiotensin system (HP:0000847)1.98804793
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.96186560
125Pigmentary retinal degeneration (HP:0001146)1.95760679
126Nephrolithiasis (HP:0000787)1.91256050
127Fatigable weakness (HP:0003473)1.91026394
128Abnormality of the neuromuscular junction (HP:0003398)1.91026394
129Abnormal hand bone ossification (HP:0010660)1.90850919
130Hyperphosphatemia (HP:0002905)1.89838238
131Woolly hair (HP:0002224)1.89717364
132Death in infancy (HP:0001522)1.89413030
133Abnormal urine phosphate concentration (HP:0012599)1.88901321
134Hyperphosphaturia (HP:0003109)1.88364354
135Abnormal ossification of hand bones (HP:0005921)1.88329174
136Biliary tract neoplasm (HP:0100574)1.86958915
137Hyperuricemia (HP:0002149)1.86845480
138Increased purine levels (HP:0004368)1.86845480
139Short 1st metacarpal (HP:0010034)1.86500119
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86500119
141Late onset (HP:0003584)1.86482195
142Esophageal varix (HP:0002040)1.86471482
143Papillary thyroid carcinoma (HP:0002895)1.85930822
144Conjugated hyperbilirubinemia (HP:0002908)1.85875345
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84985365
146Secondary amenorrhea (HP:0000869)1.84346265
147Chronic diarrhea (HP:0002028)1.84006328
148Uterine neoplasm (HP:0010784)1.83979528
149Upper limb muscle weakness (HP:0003484)1.83872407
150Vaginal fistula (HP:0004320)1.82814376
151Abnormal platelet volume (HP:0011876)1.82756205
152Thrombophlebitis (HP:0004418)1.82659120
153Abnormal platelet function (HP:0011869)1.82532545
154Impaired platelet aggregation (HP:0003540)1.82532545
155Hyperglycinemia (HP:0002154)1.82453314
156Gastrointestinal carcinoma (HP:0002672)1.82419579
157Malignant gastrointestinal tract tumors (HP:0006749)1.82419579
158Tetany (HP:0001281)1.80823841
159Hypoalphalipoproteinemia (HP:0003233)1.80427453
160Sparse lateral eyebrow (HP:0005338)1.80174018
161Fat malabsorption (HP:0002630)1.79935882
162Delayed CNS myelination (HP:0002188)1.79865866
163Megaloblastic anemia (HP:0001889)1.79713728
164Aplasia cutis congenita (HP:0001057)1.78857986
165Ventricular tachycardia (HP:0004756)1.76908182
166Abnormality of purine metabolism (HP:0004352)1.76080306
167Abnormal biliary tract morphology (HP:0012440)1.74340767
168Orchitis (HP:0100796)1.74204768
169Hypolipoproteinemia (HP:0010981)1.74113435
170Absent hand (HP:0004050)1.73724799
171Alopecia of scalp (HP:0002293)1.73381463
172Polycythemia (HP:0001901)1.72996088
173Urethral obstruction (HP:0000796)1.72143439
174Sandal gap (HP:0001852)1.71444609
175Palpitations (HP:0001962)1.70841215
176Ventricular arrhythmia (HP:0004308)1.70422686
177Esophageal atresia (HP:0002032)1.70100615
178Abnormal pancreas size (HP:0012094)1.69643204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.24863436
2EPHA24.48236464
3MAP3K94.32065208
4ACVR1B4.14774858
5ERN13.70209129
6ERBB43.55627244
7KSR23.51476186
8MAP3K133.13091061
9EEF2K2.98649627
10TAOK12.95393328
11MAP3K62.94656532
12WNK42.81698118
13FRK2.79642448
14MST1R2.72786665
15MUSK2.67154962
16FGFR32.55312068
17MST42.55172257
18TAOK32.49385996
19RIPK12.44700846
20LATS12.41073048
21STK392.34915131
22BRAF2.31356601
23ARAF2.28376388
24MAPKAPK32.06951200
25ICK1.99927427
26LATS21.99557537
27RAF11.98264973
28TTK1.84374029
29PLK41.71407010
30STK38L1.60932020
31IRAK31.48525656
32DYRK1B1.44770324
33DDR21.43951716
34MOS1.38438839
35KSR11.36923191
36TRIB31.30115693
37MAP2K21.28361017
38PRKG21.27345492
39MATK1.21330170
40PKN21.19597363
41TRPM71.19562648
42CDK91.14059125
43TESK21.13361918
44STK31.12906484
45NUAK11.12675683
46PAK61.12006035
47MAP2K11.10180814
48MELK1.10180130
49AKT31.08380113
50CDK81.08286458
51PIK3CA1.07645946
52MAPKAPK51.07478026
53EPHA31.07330213
54SIK11.06630944
55LMTK21.05234486
56FER1.03422490
57STK101.03117153
58PDK21.02875021
59PRKAA21.01839882
60GRK10.97589269
61PTK20.96650205
62EPHB20.95704389
63PDGFRA0.93895736
64PTK60.92552839
65MYLK0.92389580
66EIF2AK10.91528262
67MAP3K100.90328992
68PRKCI0.86895943
69PAK30.84422522
70MAP3K80.84097324
71NME10.83510317
72STK240.83107313
73CDC42BPA0.81723100
74PDK10.80195705
75CSF1R0.79546476
76MET0.77388066
77OXSR10.77121485
78CDK120.76625433
79MAP3K10.76473866
80PRKD20.74071758
81PRKACG0.72526915
82ZAP700.68626151
83MAP3K20.67648925
84FGFR10.67432023
85ERBB20.65860678
86TIE10.65765108
87RPS6KB20.64711119
88MAP3K120.64614458
89MAP3K30.64223035
90MARK20.61834153
91DMPK0.61411197
92NEK20.60999632
93PRKAA10.57089367
94PRPF4B0.56733729
95MAP4K10.55909802
96MAPK110.55007181
97NLK0.52557651
98EPHA40.51640586
99RIPK40.50841366
100SRC0.50511462
101PAK40.50089634
102WNK10.49272099
103PRKD30.48304653
104GRK60.44727833
105ABL20.44453813
106RET0.44077219
107FGR0.43588574
108MAP3K70.40707915
109MAPK130.40218829
110CSNK1A1L0.39949709
111MAP3K110.38199676
112SMG10.37183643
113CSNK1G20.37038823
114CAMK2A0.36851408
115PIM20.36068614
116IGF1R0.36017645
117AURKB0.35701279
118TAOK20.35436354
119PRKCZ0.34374688
120EPHB10.34090605
121TBK10.33425773
122DYRK20.33017468
123CHEK20.32294850
124CSNK1G10.32212458
125MAP3K50.31144421
126PRKCA0.30300991
127IRAK10.30155357
128SGK10.29695301
129MAPKAPK20.29510024
130BMX0.28394132
131CSNK1G30.27387004
132JAK30.25896521
133TYRO30.25849951
134ITK0.25226321
135JAK20.25204833
136CDK70.25026405
137TYK20.23197962
138CDK60.22940038
139CAMK2D0.22596427
140STK110.20542929
141MAP2K40.19696505
142LYN0.19693158
143SYK0.19329931
144PAK10.19328483
145MAP2K60.19005967
146CHUK0.18631653
147BTK0.18507706
148CAMK2G0.18452892
149MAP2K30.18305053
150ABL10.18106007
151FYN0.18019524
152PLK10.17761682
153PDPK10.17555967
154TESK10.16084025
155MAP3K40.15401794

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.97637737
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.80960096
3Fat digestion and absorption_Homo sapiens_hsa049753.27797304
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.84545317
5Complement and coagulation cascades_Homo sapiens_hsa046102.80995759
6Mineral absorption_Homo sapiens_hsa049782.78151406
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.60836020
8Caffeine metabolism_Homo sapiens_hsa002322.37194772
9Retinol metabolism_Homo sapiens_hsa008302.17603151
10Ovarian steroidogenesis_Homo sapiens_hsa049132.16958564
11Vitamin digestion and absorption_Homo sapiens_hsa049772.15754573
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14892069
13PPAR signaling pathway_Homo sapiens_hsa033202.10548296
14Fatty acid degradation_Homo sapiens_hsa000712.05698677
15Chemical carcinogenesis_Homo sapiens_hsa052042.04681792
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.04374698
17Linoleic acid metabolism_Homo sapiens_hsa005911.99871112
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99441459
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.97100621
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81864474
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81012523
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80168033
23Renin-angiotensin system_Homo sapiens_hsa046141.74870295
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.65528937
25Thyroid hormone synthesis_Homo sapiens_hsa049181.65512990
26Galactose metabolism_Homo sapiens_hsa000521.65089270
27GnRH signaling pathway_Homo sapiens_hsa049121.61581924
28Ether lipid metabolism_Homo sapiens_hsa005651.59323425
29Phenylalanine metabolism_Homo sapiens_hsa003601.57646199
30Adherens junction_Homo sapiens_hsa045201.57644319
31Bile secretion_Homo sapiens_hsa049761.55057920
32Pancreatic cancer_Homo sapiens_hsa052121.49787509
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45442712
34Small cell lung cancer_Homo sapiens_hsa052221.43369692
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40063127
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39441110
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.36774315
38Tryptophan metabolism_Homo sapiens_hsa003801.35059518
39Histidine metabolism_Homo sapiens_hsa003401.34110377
40Circadian rhythm_Homo sapiens_hsa047101.33009430
41Tight junction_Homo sapiens_hsa045301.32517133
42TGF-beta signaling pathway_Homo sapiens_hsa043501.28355682
43Dorso-ventral axis formation_Homo sapiens_hsa043201.26281184
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26113767
45Bladder cancer_Homo sapiens_hsa052191.26043462
46Staphylococcus aureus infection_Homo sapiens_hsa051501.24610672
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23841574
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21844294
49Tyrosine metabolism_Homo sapiens_hsa003501.21105812
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17498101
51VEGF signaling pathway_Homo sapiens_hsa043701.16088861
52Sulfur relay system_Homo sapiens_hsa041221.14757649
53Fatty acid metabolism_Homo sapiens_hsa012121.14607760
54Protein digestion and absorption_Homo sapiens_hsa049741.10293202
55Cell cycle_Homo sapiens_hsa041101.09245540
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09147364
57Nitrogen metabolism_Homo sapiens_hsa009101.09074911
58Olfactory transduction_Homo sapiens_hsa047401.08947147
59Choline metabolism in cancer_Homo sapiens_hsa052311.06501687
60Thyroid cancer_Homo sapiens_hsa052161.04725000
61Prolactin signaling pathway_Homo sapiens_hsa049171.03514189
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01585910
63Glycerophospholipid metabolism_Homo sapiens_hsa005641.01240343
64Toxoplasmosis_Homo sapiens_hsa051451.00823554
65Arginine biosynthesis_Homo sapiens_hsa002201.00409990
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99842740
67Peroxisome_Homo sapiens_hsa041460.99134532
68Amoebiasis_Homo sapiens_hsa051460.98634580
69Biosynthesis of amino acids_Homo sapiens_hsa012300.95772762
70TNF signaling pathway_Homo sapiens_hsa046680.93524481
71Starch and sucrose metabolism_Homo sapiens_hsa005000.92947722
72ECM-receptor interaction_Homo sapiens_hsa045120.92121569
73Colorectal cancer_Homo sapiens_hsa052100.90500973
74Sphingolipid metabolism_Homo sapiens_hsa006000.89693237
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88808126
76Endometrial cancer_Homo sapiens_hsa052130.88426868
77Folate biosynthesis_Homo sapiens_hsa007900.87956302
78Renal cell carcinoma_Homo sapiens_hsa052110.86529418
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86475024
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83987447
81Arachidonic acid metabolism_Homo sapiens_hsa005900.83636288
82RNA degradation_Homo sapiens_hsa030180.82716958
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82191848
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82018846
85Hippo signaling pathway_Homo sapiens_hsa043900.81028889
86Other glycan degradation_Homo sapiens_hsa005110.80043381
87Pyruvate metabolism_Homo sapiens_hsa006200.79107238
88Butanoate metabolism_Homo sapiens_hsa006500.77267534
89Estrogen signaling pathway_Homo sapiens_hsa049150.75990155
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74126519
91Salmonella infection_Homo sapiens_hsa051320.74082134
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73336730
93Carbon metabolism_Homo sapiens_hsa012000.70318612
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.69562839
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67655567
96Hepatitis C_Homo sapiens_hsa051600.64653244
97Arginine and proline metabolism_Homo sapiens_hsa003300.63672295
98Salivary secretion_Homo sapiens_hsa049700.62519443
99ABC transporters_Homo sapiens_hsa020100.61674633
100MicroRNAs in cancer_Homo sapiens_hsa052060.59100948
101p53 signaling pathway_Homo sapiens_hsa041150.58240842
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57595111
103Hepatitis B_Homo sapiens_hsa051610.55042074
104Focal adhesion_Homo sapiens_hsa045100.54212142
105FoxO signaling pathway_Homo sapiens_hsa040680.54167562
106Glutathione metabolism_Homo sapiens_hsa004800.54164343
107Steroid biosynthesis_Homo sapiens_hsa001000.53839910
108Chronic myeloid leukemia_Homo sapiens_hsa052200.53822315
109Oocyte meiosis_Homo sapiens_hsa041140.52620627
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51920095
111Sulfur metabolism_Homo sapiens_hsa009200.51804040
112Shigellosis_Homo sapiens_hsa051310.51296329
113beta-Alanine metabolism_Homo sapiens_hsa004100.51153042
114Fatty acid elongation_Homo sapiens_hsa000620.50191933
115Influenza A_Homo sapiens_hsa051640.49720043
116Glycerolipid metabolism_Homo sapiens_hsa005610.49510224
117Rap1 signaling pathway_Homo sapiens_hsa040150.49395299
118Inositol phosphate metabolism_Homo sapiens_hsa005620.48496685
119Ras signaling pathway_Homo sapiens_hsa040140.48217960
120Propanoate metabolism_Homo sapiens_hsa006400.48089973
121Vitamin B6 metabolism_Homo sapiens_hsa007500.47969656
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47554012
123Long-term depression_Homo sapiens_hsa047300.47501624
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46987254
125HIF-1 signaling pathway_Homo sapiens_hsa040660.46218317
126African trypanosomiasis_Homo sapiens_hsa051430.45788546
127ErbB signaling pathway_Homo sapiens_hsa040120.45683381
128Hematopoietic cell lineage_Homo sapiens_hsa046400.45679699
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43939907
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.43617442
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43339196
132Fatty acid biosynthesis_Homo sapiens_hsa000610.42970359
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42808323
134Pancreatic secretion_Homo sapiens_hsa049720.42696232
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42691168
136Metabolic pathways_Homo sapiens_hsa011000.41603738
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41216316
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39778545
139Pentose phosphate pathway_Homo sapiens_hsa000300.39732408
140Fructose and mannose metabolism_Homo sapiens_hsa000510.38874444
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38803243
142Pertussis_Homo sapiens_hsa051330.37358118
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.37325929
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.29197820
145Insulin resistance_Homo sapiens_hsa049310.28355659
146Prion diseases_Homo sapiens_hsa050200.27926847
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.27237942
148N-Glycan biosynthesis_Homo sapiens_hsa005100.25657311
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25258455
150Systemic lupus erythematosus_Homo sapiens_hsa053220.15031532
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10557721
152Lysine degradation_Homo sapiens_hsa003100.08807773
153Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.08407815
154Glucagon signaling pathway_Homo sapiens_hsa049220.07562350
155Asthma_Homo sapiens_hsa053100.06562770
156AMPK signaling pathway_Homo sapiens_hsa04152-0.0537285
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0108656
158Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0031958

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