ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	polyketide metabolic process (GO:0030638)	8.30021483
2	doxorubicin metabolic process (GO:0044598)	8.30021483
3	daunorubicin metabolic process (GO:0044597)	8.30021483
4	aminoglycoside antibiotic metabolic process (GO:0030647)	7.33766637
5	primary alcohol catabolic process (GO:0034310)	4.61144870
6	quinone metabolic process (GO:1901661)	4.25804261
7	behavioral response to nicotine (GO:0035095)	4.07537526
8	regulation of hippo signaling (GO:0035330)	3.82692314
9	cysteine metabolic process (GO:0006534)	3.57851586
10	kynurenine metabolic process (GO:0070189)	3.56348712
11	glycoside metabolic process (GO:0016137)	3.43780275
12	cellular ketone body metabolic process (GO:0046950)	3.23592011
13	L-fucose catabolic process (GO:0042355)	3.22621747
14	fucose catabolic process (GO:0019317)	3.22621747
15	L-fucose metabolic process (GO:0042354)	3.22621747
16	retinal metabolic process (GO:0042574)	3.19487534
17	flavonoid metabolic process (GO:0009812)	3.14352472
18	protein K6-linked ubiquitination (GO:0085020)	3.04204267
19	ketone body metabolic process (GO:1902224)	3.00706072
20	maturation of 5.8S rRNA (GO:0000460)	3.00314008
21	respiratory chain complex IV assembly (GO:0008535)	2.97765271
22	cornea development in camera-type eye (GO:0061303)	2.97643435
23	water-soluble vitamin biosynthetic process (GO:0042364)	2.95008047
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.88702840
25	ATP synthesis coupled proton transport (GO:0015986)	2.88104330
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.88104330
27	retinoic acid metabolic process (GO:0042573)	2.87558752
28	tryptophan catabolic process (GO:0006569)	2.82408903
29	indole-containing compound catabolic process (GO:0042436)	2.82408903
30	indolalkylamine catabolic process (GO:0046218)	2.82408903
31	proteasome assembly (GO:0043248)	2.80397602
32	ubiquinone biosynthetic process (GO:0006744)	2.78886690
33	protein complex biogenesis (GO:0070271)	2.76805678
34	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76793008
35	mannosylation (GO:0097502)	2.75806682
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75750541
37	NADH dehydrogenase complex assembly (GO:0010257)	2.75750541
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75750541
39	DNA deamination (GO:0045006)	2.74557333
40	pseudouridine synthesis (GO:0001522)	2.71860152
41	piRNA metabolic process (GO:0034587)	2.70625204
42	response to pheromone (GO:0019236)	2.70340142
43	mitochondrial RNA metabolic process (GO:0000959)	2.68952388
44	cellular ketone metabolic process (GO:0042180)	2.68584877
45	tRNA modification (GO:0006400)	2.65355375
46	mitochondrion morphogenesis (GO:0070584)	2.61191401
47	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.58379834
48	cellular aldehyde metabolic process (GO:0006081)	2.57366126
49	ubiquinone metabolic process (GO:0006743)	2.56049710
50	tRNA processing (GO:0008033)	2.55345266
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.53737298
52	response to growth hormone (GO:0060416)	2.52932229
53	cellular glucuronidation (GO:0052695)	2.52502027
54	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.50439598
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50306062
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50306062
57	glucuronate metabolic process (GO:0019585)	2.48806735
58	uronic acid metabolic process (GO:0006063)	2.48806735
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48446318
60	protein-cofactor linkage (GO:0018065)	2.47068809
61	electron transport chain (GO:0022900)	2.46137728
62	tRNA methylation (GO:0030488)	2.44694855
63	terpenoid biosynthetic process (GO:0016114)	2.43372980
64	cytochrome complex assembly (GO:0017004)	2.43298217
65	epithelial cilium movement (GO:0003351)	2.43070884
66	negative regulation of telomere maintenance (GO:0032205)	2.41273245
67	axonemal dynein complex assembly (GO:0070286)	2.40727042
68	peptidyl-histidine modification (GO:0018202)	2.39671527
69	secondary metabolic process (GO:0019748)	2.36327441
70	tryptophan metabolic process (GO:0006568)	2.35752988
71	response to nitrosative stress (GO:0051409)	2.35181687
72	indolalkylamine metabolic process (GO:0006586)	2.34709317
73	respiratory electron transport chain (GO:0022904)	2.33070564
74	regulation of cilium movement (GO:0003352)	2.32275710
75	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.30820162
76	protein import into peroxisome matrix (GO:0016558)	2.30745426
77	response to food (GO:0032094)	2.30130677
78	protein neddylation (GO:0045116)	2.26017141
79	drug transmembrane transport (GO:0006855)	2.24909343
80	cAMP catabolic process (GO:0006198)	2.20526453
81	negative regulation of T cell differentiation in thymus (GO:0033085)	2.20388071
82	histone-serine phosphorylation (GO:0035404)	2.19656438
83	intracellular protein transmembrane import (GO:0044743)	2.16687936
84	replication fork processing (GO:0031297)	2.16478464
85	L-methionine salvage (GO:0071267)	2.16264625
86	L-methionine biosynthetic process (GO:0071265)	2.16264625
87	amino acid salvage (GO:0043102)	2.16264625
88	tRNA metabolic process (GO:0006399)	2.16263670
89	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.16129986
90	opioid receptor signaling pathway (GO:0038003)	2.15803594
91	fat-soluble vitamin catabolic process (GO:0042363)	2.15706754
92	vitamin catabolic process (GO:0009111)	2.15706754
93	protein polyglutamylation (GO:0018095)	2.14846200
94	diterpenoid biosynthetic process (GO:0016102)	2.14326931
95	spindle assembly involved in mitosis (GO:0090307)	2.13945036
96	indole-containing compound metabolic process (GO:0042430)	2.13839873
97	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.13560827
98	nonmotile primary cilium assembly (GO:0035058)	2.12928031
99	amine catabolic process (GO:0009310)	2.12770774
100	cellular biogenic amine catabolic process (GO:0042402)	2.12770774

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.74055285
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73206643
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29632610
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07727359
5	VDR_22108803_ChIP-Seq_LS180_Human	2.95488117
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.84525062
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.66556975
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44783488
9	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.36681563
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.32950755
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27656661
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.22551494
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.19328853
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04416688
15	MYC_18940864_ChIP-ChIP_HL60_Human	2.04268156
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.02950443
17	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.96867401
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86128060
19	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.78889139
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70987477
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.67748697
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66564635
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.65216309
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.62402718
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60647860
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.56569367
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.54739727
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52492478
29	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.51603088
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.48012502
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.47915659
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.45687179
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.44916751
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.43333546
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.41999826
36	EWS_26573619_Chip-Seq_HEK293_Human	1.40663432
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35733705
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.34878173
39	HOXB7_26014856_ChIP-Seq_BT474_Human	1.34238973
40	GABP_19822575_ChIP-Seq_HepG2_Human	1.33263466
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32850665
42	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.32149385
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30468854
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30345054
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30345054
46	FUS_26573619_Chip-Seq_HEK293_Human	1.29862726
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.29855748
48	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.26600530
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.26008684
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25380379
51	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21857910
52	AR_20517297_ChIP-Seq_VCAP_Human	1.21190327
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21169221
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20991180
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20148577
56	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.19641551
57	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.16356975
58	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.15503708
59	* GATA4_25053715_ChIP-Seq_YYC3_Human	1.13646339
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.08250968
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.07625709
62	KDM5A_27292631_Chip-Seq_BREAST_Human	1.06110468
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05958391
64	* CJUN_26792858_Chip-Seq_BT549_Human	1.04820877
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.04685478
66	ERA_21632823_ChIP-Seq_H3396_Human	1.03317086
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01716906
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00927586
69	ELF5_23300383_ChIP-Seq_T47D_Human	1.00097713
70	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99984787
71	TTF2_22483619_ChIP-Seq_HELA_Human	0.98857622
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97404190
73	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97088045
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.96838416
75	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94483947
76	FOXP3_21729870_ChIP-Seq_TREG_Human	0.93887085
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92878340
78	* P53_21459846_ChIP-Seq_SAOS-2_Human	0.90779293
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.90273679
80	XRN2_22483619_ChIP-Seq_HELA_Human	0.90224343
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89132719
82	ZNF263_19887448_ChIP-Seq_K562_Human	0.87054524
83	AR_25329375_ChIP-Seq_VCAP_Human	0.86734324
84	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.86459027
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86192167
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86192167
87	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86187347
88	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.86081296
89	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.85016346
90	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.83870294
91	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.83764936
92	P300_19829295_ChIP-Seq_ESCs_Human	0.82891733
93	NCOR_22424771_ChIP-Seq_293T_Human	0.82817292
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.81603531
95	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.81484226
96	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.81484226
97	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.79277928
98	IGF1R_20145208_ChIP-Seq_DFB_Human	0.79260568
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.79120472
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.78884992

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	4.66233778
2	MP0003806_abnormal_nucleotide_metabolis	3.16616475
3	MP0002102_abnormal_ear_morphology	2.53377006
4	MP0003646_muscle_fatigue	2.47091815
5	MP0003136_yellow_coat_color	2.29792784
6	MP0002938_white_spotting	2.10628595
7	MP0000383_abnormal_hair_follicle	2.09807937
8	MP0003186_abnormal_redox_activity	1.94408640
9	MP0002234_abnormal_pharynx_morphology	1.91834403
10	MP0000427_abnormal_hair_cycle	1.90087070
11	MP0002837_dystrophic_cardiac_calcinosis	1.86856719
12	MP0008872_abnormal_physiological_respon	1.86628439
13	MP0002736_abnormal_nociception_after	1.77095998
14	MP0004133_heterotaxia	1.76573360
15	MP0008058_abnormal_DNA_repair	1.71764600
16	MP0001968_abnormal_touch/_nociception	1.71541536
17	MP0000579_abnormal_nail_morphology	1.70241605
18	MP0002876_abnormal_thyroid_physiology	1.69181420
19	MP0003950_abnormal_plasma_membrane	1.68656449
20	MP0002160_abnormal_reproductive_system	1.64841107
21	MP0000372_irregular_coat_pigmentation	1.63308247
22	MP0005551_abnormal_eye_electrophysiolog	1.61697309
23	MP0003195_calcinosis	1.59756682
24	MP0001348_abnormal_lacrimal_gland	1.59433195
25	MP0005645_abnormal_hypothalamus_physiol	1.50337920
26	MP0010678_abnormal_skin_adnexa	1.48412401
27	MP0003283_abnormal_digestive_organ	1.46339877
28	MP0009046_muscle_twitch	1.46252063
29	MP0004142_abnormal_muscle_tone	1.37260703
30	MP0004233_abnormal_muscle_weight	1.37168631
31	MP0008877_abnormal_DNA_methylation	1.36884099
32	MP0000647_abnormal_sebaceous_gland	1.34990812
33	MP0006072_abnormal_retinal_apoptosis	1.34858732
34	MP0009780_abnormal_chondrocyte_physiolo	1.34682409
35	MP0005332_abnormal_amino_acid	1.28588645
36	MP0002928_abnormal_bile_duct	1.27065891
37	MP0001529_abnormal_vocalization	1.26421224
38	MP0002638_abnormal_pupillary_reflex	1.24632042
39	MP0008775_abnormal_heart_ventricle	1.24607495
40	MP0005389_reproductive_system_phenotype	1.24583150
41	MP0003011_delayed_dark_adaptation	1.23574057
42	MP0003718_maternal_effect	1.22387142
43	MP0004043_abnormal_pH_regulation	1.18113352
44	MP0010030_abnormal_orbit_morphology	1.17554853
45	MP0005253_abnormal_eye_physiology	1.16013570
46	MP0001661_extended_life_span	1.13858797
47	MP0003937_abnormal_limbs/digits/tail_de	1.13709801
48	MP0005083_abnormal_biliary_tract	1.11317735
49	MP0009379_abnormal_foot_pigmentation	1.09971361
50	MP0000013_abnormal_adipose_tissue	1.08979290
51	MP0000749_muscle_degeneration	1.08429876
52	MP0005195_abnormal_posterior_eye	1.08241814
53	MP0000762_abnormal_tongue_morphology	1.07866048
54	MP0000631_abnormal_neuroendocrine_gland	1.06796667
55	MP0004147_increased_porphyrin_level	1.03982463
56	MP0003252_abnormal_bile_duct	1.03688590
57	MP0002653_abnormal_ependyma_morphology	1.03505416
58	MP0002272_abnormal_nervous_system	1.02773139
59	MP0005646_abnormal_pituitary_gland	1.01282420
60	MP0002909_abnormal_adrenal_gland	1.00835792
61	MP0003693_abnormal_embryo_hatching	1.00558618
62	MP0003786_premature_aging	1.00109252
63	MP0001905_abnormal_dopamine_level	0.99204493
64	MP0001485_abnormal_pinna_reflex	0.98790754
65	MP0005408_hypopigmentation	0.97508555
66	MP0009053_abnormal_anal_canal	0.97084217
67	MP0003137_abnormal_impulse_conducting	0.96785479
68	MP0000538_abnormal_urinary_bladder	0.96595176
69	MP0009745_abnormal_behavioral_response	0.95820998
70	MP0010094_abnormal_chromosome_stability	0.95054150
71	MP0004019_abnormal_vitamin_homeostasis	0.93122038
72	MP0000569_abnormal_digit_pigmentation	0.90740411
73	MP0004215_abnormal_myocardial_fiber	0.90345240
74	MP0004145_abnormal_muscle_electrophysio	0.88665639
75	MP0009697_abnormal_copulation	0.88521993
76	MP0004885_abnormal_endolymph	0.87521325
77	MP0003755_abnormal_palate_morphology	0.87085954
78	MP0000750_abnormal_muscle_regeneration	0.85873581
79	MP0000358_abnormal_cell_content/	0.85681755
80	MP0001919_abnormal_reproductive_system	0.83814488
81	MP0001986_abnormal_taste_sensitivity	0.82945963
82	MP0005174_abnormal_tail_pigmentation	0.82562495
83	MP0005085_abnormal_gallbladder_physiolo	0.82180940
84	MP0002184_abnormal_innervation	0.81551286
85	MP0005266_abnormal_metabolism	0.81514876
86	MP0006036_abnormal_mitochondrial_physio	0.81075075
87	MP0008007_abnormal_cellular_replicative	0.79954421
88	MP0005391_vision/eye_phenotype	0.79148888
89	MP0002332_abnormal_exercise_endurance	0.77814670
90	MP0002733_abnormal_thermal_nociception	0.77188656
91	MP0004924_abnormal_behavior	0.76787871
92	MP0005386_behavior/neurological_phenoty	0.76787871
93	MP0002735_abnormal_chemical_nociception	0.76769441
94	MP0006276_abnormal_autonomic_nervous	0.76372007
95	MP0001502_abnormal_circadian_rhythm	0.75644403
96	MP0001324_abnormal_eye_pigmentation	0.75525725
97	MP0002697_abnormal_eye_size	0.75400849
98	MP0005171_absent_coat_pigmentation	0.74534947
99	MP0001286_abnormal_eye_development	0.74102694
100	MP0002210_abnormal_sex_determination	0.73970735

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.33071480
2	Pancreatic cysts (HP:0001737)	3.78968516
3	Abnormality of midbrain morphology (HP:0002418)	3.74030602
4	Molar tooth sign on MRI (HP:0002419)	3.74030602
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.58808007
6	Abnormality of alanine metabolism (HP:0010916)	3.58808007
7	Hyperalaninemia (HP:0003348)	3.58808007
8	Pancreatic fibrosis (HP:0100732)	3.56989349
9	Cerebellar dysplasia (HP:0007033)	3.37257537
10	True hermaphroditism (HP:0010459)	3.31552321
11	Nephronophthisis (HP:0000090)	3.02894153
12	Tubular atrophy (HP:0000092)	3.00770931
13	Abnormality of the renal cortex (HP:0011035)	2.89856723
14	Congenital stationary night blindness (HP:0007642)	2.89160310
15	Severe muscular hypotonia (HP:0006829)	2.69253093
16	Congenital, generalized hypertrichosis (HP:0004540)	2.65451571
17	Increased CSF lactate (HP:0002490)	2.64317011
18	Pendular nystagmus (HP:0012043)	2.64271248
19	Concave nail (HP:0001598)	2.61086128
20	Hepatic necrosis (HP:0002605)	2.60364403
21	Large for gestational age (HP:0001520)	2.58622313
22	Sclerocornea (HP:0000647)	2.58539456
23	Mitochondrial inheritance (HP:0001427)	2.56676715
24	Abnormality of the renal medulla (HP:0100957)	2.54683868
25	Hepatocellular necrosis (HP:0001404)	2.47683931
26	Chorioretinal atrophy (HP:0000533)	2.46087359
27	Increased hepatocellular lipid droplets (HP:0006565)	2.42301738
28	Lipid accumulation in hepatocytes (HP:0006561)	2.42185006
29	Lissencephaly (HP:0001339)	2.40975586
30	Acute necrotizing encephalopathy (HP:0006965)	2.36859591
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.36406937
32	Renal cortical cysts (HP:0000803)	2.33809361
33	Cystic liver disease (HP:0006706)	2.32944414
34	Birth length less than 3rd percentile (HP:0003561)	2.32701157
35	Abnormality of the pons (HP:0007361)	2.18908942
36	Absent thumb (HP:0009777)	2.17729706
37	Partial agenesis of the corpus callosum (HP:0001338)	2.17669833
38	Hypoplasia of the pons (HP:0012110)	2.16060109
39	Medial flaring of the eyebrow (HP:0010747)	2.15826139
40	Furrowed tongue (HP:0000221)	2.15558110
41	Testicular atrophy (HP:0000029)	2.13692882
42	Adrenal hypoplasia (HP:0000835)	2.13608088
43	Keratoconus (HP:0000563)	2.13118413
44	Increased corneal curvature (HP:0100692)	2.13118413
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12431542
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.12431542
47	Increased serum lactate (HP:0002151)	2.11672270
48	Abnormal number of erythroid precursors (HP:0012131)	2.10668137
49	Retinal dysplasia (HP:0007973)	2.07992305
50	Acute encephalopathy (HP:0006846)	2.06426162
51	Abnormality of cells of the erythroid lineage (HP:0012130)	2.05208330
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.04807817
53	Absent/shortened dynein arms (HP:0200106)	2.04807817
54	Hyperventilation (HP:0002883)	2.03424563
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.01752375
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.00255281
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99157437
58	Pachygyria (HP:0001302)	1.94286960
59	Chronic hepatic failure (HP:0100626)	1.90593925
60	Abnormality of the carotid arteries (HP:0005344)	1.90526310
61	Tongue fasciculations (HP:0001308)	1.88866815
62	Renal Fanconi syndrome (HP:0001994)	1.87632406
63	Occipital encephalocele (HP:0002085)	1.86232537
64	Progressive macrocephaly (HP:0004481)	1.85971364
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.85449591
66	Microretrognathia (HP:0000308)	1.84629071
67	Chromsome breakage (HP:0040012)	1.83013477
68	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.82499691
69	Attenuation of retinal blood vessels (HP:0007843)	1.81860466
70	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81706124
71	Elfin facies (HP:0004428)	1.81245206
72	Patellar aplasia (HP:0006443)	1.79975712
73	Abnormal ciliary motility (HP:0012262)	1.77420085
74	Hypoplasia of the uterus (HP:0000013)	1.76736926
75	Fibular aplasia (HP:0002990)	1.76596599
76	Optic disc pallor (HP:0000543)	1.75725936
77	Brittle hair (HP:0002299)	1.75077053
78	Lactic acidosis (HP:0003128)	1.74429302
79	Tachypnea (HP:0002789)	1.72904563
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72873573
81	Abnormality of the ileum (HP:0001549)	1.72831576
82	Male pseudohermaphroditism (HP:0000037)	1.72755268
83	Inability to walk (HP:0002540)	1.70956004
84	Optic nerve hypoplasia (HP:0000609)	1.70607216
85	Abnormal biliary tract physiology (HP:0012439)	1.67533792
86	Bile duct proliferation (HP:0001408)	1.67533792
87	Meckel diverticulum (HP:0002245)	1.66149314
88	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.63732894
89	Bilateral microphthalmos (HP:0007633)	1.62811280
90	Duplicated collecting system (HP:0000081)	1.62470251
91	Lethargy (HP:0001254)	1.61988568
92	Increased intramyocellular lipid droplets (HP:0012240)	1.61763164
93	Ketoacidosis (HP:0001993)	1.61720970
94	Progressive inability to walk (HP:0002505)	1.60854858
95	Gait imbalance (HP:0002141)	1.60537558
96	Delayed gross motor development (HP:0002194)	1.60235357
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.59440513
98	Anencephaly (HP:0002323)	1.58733095
99	Disproportionate short-trunk short stature (HP:0003521)	1.57759431
100	Congenital primary aphakia (HP:0007707)	1.57164307

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	2.97890883
2	ZAK	2.95154299
3	TLK1	2.88023107
4	ERBB4	2.86246470
5	FRK	2.75480867
6	BMPR1B	2.53445011
7	ADRBK2	2.45322935
8	MET	2.40634161
9	IRAK3	2.23589830
10	ACVR1B	2.13139512
11	EPHA2	2.10834115
12	PBK	2.10631445
13	WNK4	2.01758003
14	VRK2	1.91587718
15	BRSK2	1.87411749
16	LIMK1	1.84862488
17	CASK	1.83023103
18	MAPKAPK3	1.67143191
19	WEE1	1.60431616
20	GRK1	1.58855990
21	NUAK1	1.51440129
22	TSSK6	1.50755112
23	PNCK	1.48863283
24	NEK1	1.46855815
25	EIF2AK1	1.44712572
26	PHKG1	1.42962849
27	PHKG2	1.42962849
28	TRIM28	1.42459426
29	MAP4K2	1.39451792
30	PINK1	1.38621137
31	NME1	1.32164273
32	NEK2	1.31905302
33	WNK3	1.30727291
34	PRKCI	1.29837029
35	BUB1	1.26563206
36	MUSK	1.19542117
37	MAPKAPK5	1.14103229
38	ADRBK1	1.14100039
39	CAMKK2	1.13848537
40	STK39	1.11016593
41	STK16	1.04486774
42	RPS6KB2	1.04190481
43	CDK8	1.02612536
44	INSRR	1.02270866
45	BRSK1	0.98809910
46	IRAK1	0.98609221
47	MST4	0.94798048
48	TTN	0.92345111
49	VRK1	0.90744697
50	TGFBR1	0.89878038
51	MAP2K7	0.88692350
52	MAPK15	0.87408183
53	FLT3	0.82993096
54	MAP2K1	0.82248761
55	CHEK2	0.80579007
56	MAP3K12	0.80241162
57	PLK1	0.77946974
58	NME2	0.77401141
59	PLK3	0.75481568
60	PRKCE	0.75228341
61	CAMK2G	0.72259174
62	TRPM7	0.71921653
63	TAF1	0.70088166
64	MAP2K2	0.69812849
65	AURKA	0.68229123
66	MAPK13	0.67736648
67	OBSCN	0.66318118
68	ABL2	0.66034255
69	CAMK2B	0.63335671
70	CAMK2D	0.63294810
71	ERBB3	0.61324458
72	TTK	0.58804864
73	RPS6KA5	0.57639000
74	CSNK1G3	0.57043583
75	STK38L	0.56353460
76	AURKB	0.55098596
77	BCR	0.53577392
78	PIM2	0.53508109
79	PTK2B	0.53293142
80	DAPK2	0.51160310
81	PLK4	0.50225777
82	PLK2	0.49493735
83	SRPK1	0.47903144
84	PTK2	0.46982654
85	PAK3	0.46981333
86	CSNK1G2	0.44494712
87	DYRK2	0.43438506
88	BCKDK	0.42887676
89	CSNK1A1L	0.42397314
90	AKT2	0.40871643
91	CAMK2A	0.40622497
92	PRKCG	0.40358887
93	MAPK11	0.38863300
94	CSNK1G1	0.38790186
95	OXSR1	0.37054029
96	MAP2K6	0.36739226
97	MAP3K9	0.36634020
98	MELK	0.36109149
99	STK38	0.35325573
100	BRAF	0.35283398

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.00269032
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.88102841
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.71293339
4	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.67591292
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44352366
6	Proteasome_Homo sapiens_hsa03050	2.24872294
7	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.08771256
8	Nitrogen metabolism_Homo sapiens_hsa00910	1.90206310
9	Parkinsons disease_Homo sapiens_hsa05012	1.88793116
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88035532
11	Ribosome_Homo sapiens_hsa03010	1.83924635
12	Homologous recombination_Homo sapiens_hsa03440	1.80322121
13	Chemical carcinogenesis_Homo sapiens_hsa05204	1.79262055
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.69784545
15	One carbon pool by folate_Homo sapiens_hsa00670	1.67440559
16	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.66170994
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59336500
18	Protein export_Homo sapiens_hsa03060	1.55505911
19	RNA polymerase_Homo sapiens_hsa03020	1.53901711
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52886438
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52170777
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45958026
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.43804291
24	Glutathione metabolism_Homo sapiens_hsa00480	1.43202076
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42891794
26	Huntingtons disease_Homo sapiens_hsa05016	1.42092665
27	Sulfur relay system_Homo sapiens_hsa04122	1.40850050
28	Alzheimers disease_Homo sapiens_hsa05010	1.38981322
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38787246
30	Phototransduction_Homo sapiens_hsa04744	1.38767333
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.38670413
32	Folate biosynthesis_Homo sapiens_hsa00790	1.36105730
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.35597918
34	Sulfur metabolism_Homo sapiens_hsa00920	1.34632302
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34400387
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.31838720
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30600615
38	Basal transcription factors_Homo sapiens_hsa03022	1.27998815
39	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.25733206
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25643243
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.21252344
42	Butanoate metabolism_Homo sapiens_hsa00650	1.17001670
43	ABC transporters_Homo sapiens_hsa02010	1.15820230
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13606834
45	Peroxisome_Homo sapiens_hsa04146	1.10281273
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10193166
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.09973300
48	Pyruvate metabolism_Homo sapiens_hsa00620	1.09271223
49	Mismatch repair_Homo sapiens_hsa03430	1.08676521
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08000190
51	Retinol metabolism_Homo sapiens_hsa00830	1.07080512
52	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.04231734
53	Histidine metabolism_Homo sapiens_hsa00340	1.03059069
54	Caffeine metabolism_Homo sapiens_hsa00232	1.01258954
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99501879
56	RNA degradation_Homo sapiens_hsa03018	0.98646981
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97621695
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.97605515
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91484087
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90473044
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89853638
62	Purine metabolism_Homo sapiens_hsa00230	0.88079704
63	Metabolic pathways_Homo sapiens_hsa01100	0.87998555
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87672195
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86115821
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.84867090
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.84218712
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83454667
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82155524
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.81813536
71	DNA replication_Homo sapiens_hsa03030	0.81721209
72	Galactose metabolism_Homo sapiens_hsa00052	0.81156785
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.77013993
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.75522744
75	RNA transport_Homo sapiens_hsa03013	0.74323577
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71754587
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.68790819
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68145107
79	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66673642
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.61070424
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60219080
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58622532
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55759962
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.54874448
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.54805632
86	Propanoate metabolism_Homo sapiens_hsa00640	0.54729462
87	Carbon metabolism_Homo sapiens_hsa01200	0.53673663
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53009848
89	Nicotine addiction_Homo sapiens_hsa05033	0.52962031
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52887924
91	Base excision repair_Homo sapiens_hsa03410	0.52621673
92	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50727973
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45039675
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44967315
95	Fatty acid degradation_Homo sapiens_hsa00071	0.44104537
96	Morphine addiction_Homo sapiens_hsa05032	0.43007079
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42172735
98	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.39072834
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.38280609
100	Fatty acid elongation_Homo sapiens_hsa00062	0.37079361

TRIM16L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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