Rank | Gene Set | Z-score |
---|---|---|
1 | multicellular organism reproduction (GO:0032504) | 9.40695043 |
2 | binding of sperm to zona pellucida (GO:0007339) | 9.39134856 |
3 | cell-cell recognition (GO:0009988) | 9.28478560 |
4 | plasma membrane fusion (GO:0045026) | 9.12952566 |
5 | axonemal dynein complex assembly (GO:0070286) | 8.88099871 |
6 | epithelial cilium movement (GO:0003351) | 8.78031180 |
7 | motile cilium assembly (GO:0044458) | 8.73972809 |
8 | spermatid development (GO:0007286) | 8.67714564 |
9 | cilium or flagellum-dependent cell motility (GO:0001539) | 8.20592594 |
10 | reproduction (GO:0000003) | 8.04270140 |
11 | regulation of cilium movement (GO:0003352) | 7.95606560 |
12 | cilium movement (GO:0003341) | 7.29059450 |
13 | sperm capacitation (GO:0048240) | 7.00841474 |
14 | response to pheromone (GO:0019236) | 6.77822039 |
15 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 6.72903873 |
16 | negative regulation of inclusion body assembly (GO:0090084) | 6.71278015 |
17 | single fertilization (GO:0007338) | 6.64905425 |
18 | synaptonemal complex organization (GO:0070193) | 6.38851670 |
19 | male meiosis (GO:0007140) | 6.22128219 |
20 | piRNA metabolic process (GO:0034587) | 6.15414355 |
21 | synaptonemal complex assembly (GO:0007130) | 6.14966593 |
22 | spermatogenesis (GO:0007283) | 6.10269667 |
23 | male gamete generation (GO:0048232) | 6.07547812 |
24 | microtubule depolymerization (GO:0007019) | 5.91211647 |
25 | calcium ion-dependent exocytosis (GO:0017156) | 5.81650206 |
26 | organic cation transport (GO:0015695) | 5.75710003 |
27 | fertilization (GO:0009566) | 5.59601324 |
28 | gamete generation (GO:0007276) | 5.59012703 |
29 | regulation of inclusion body assembly (GO:0090083) | 5.40570063 |
30 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.16234130 |
31 | cell recognition (GO:0008037) | 4.99938031 |
32 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 4.89156078 |
33 | regulation of microtubule-based movement (GO:0060632) | 4.89011478 |
34 | protein targeting to Golgi (GO:0000042) | 4.88307250 |
35 | germ cell development (GO:0007281) | 4.82060445 |
36 | rRNA methylation (GO:0031167) | 4.78081025 |
37 | establishment of protein localization to Golgi (GO:0072600) | 4.73561875 |
38 | regulation of Rab GTPase activity (GO:0032313) | 4.73324680 |
39 | positive regulation of Rab GTPase activity (GO:0032851) | 4.73324680 |
40 | ventricular system development (GO:0021591) | 4.68396406 |
41 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.66114620 |
42 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 4.59811647 |
43 | microtubule severing (GO:0051013) | 4.53787857 |
44 | chromatin silencing (GO:0006342) | 4.44908302 |
45 | multicellular organismal reproductive process (GO:0048609) | 4.37199471 |
46 | male meiosis I (GO:0007141) | 4.28676241 |
47 | chromosome condensation (GO:0030261) | 4.22105002 |
48 | seminiferous tubule development (GO:0072520) | 4.21709626 |
49 | spermatid nucleus differentiation (GO:0007289) | 4.20334408 |
50 | left/right pattern formation (GO:0060972) | 4.19490497 |
51 | DNA packaging (GO:0006323) | 4.11999207 |
52 | regulation of ARF GTPase activity (GO:0032312) | 4.10950231 |
53 | regulation of transcription involved in cell fate commitment (GO:0060850) | 4.07440058 |
54 | chromosome organization involved in meiosis (GO:0070192) | 3.96660043 |
55 | DNA methylation involved in gamete generation (GO:0043046) | 3.91517490 |
56 | protein localization to cilium (GO:0061512) | 3.89595983 |
57 | single strand break repair (GO:0000012) | 3.80711482 |
58 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.76024084 |
59 | glycerol ether metabolic process (GO:0006662) | 3.74479839 |
60 | rRNA modification (GO:0000154) | 3.72535896 |
61 | cranial nerve morphogenesis (GO:0021602) | 3.72162264 |
62 | protein polyglutamylation (GO:0018095) | 3.61862608 |
63 | ether metabolic process (GO:0018904) | 3.58574278 |
64 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.57884540 |
65 | sodium ion export (GO:0071436) | 3.56869318 |
66 | coenzyme catabolic process (GO:0009109) | 3.56627896 |
67 | meiotic nuclear division (GO:0007126) | 3.56371078 |
68 | protein localization to Golgi apparatus (GO:0034067) | 3.56317316 |
69 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.54688938 |
70 | cerebral cortex neuron differentiation (GO:0021895) | 3.51467138 |
71 | cellular ketone body metabolic process (GO:0046950) | 3.49871656 |
72 | locomotory exploration behavior (GO:0035641) | 3.49771291 |
73 | multicellular organismal development (GO:0007275) | 3.49372208 |
74 | centriole assembly (GO:0098534) | 3.49065833 |
75 | synaptic vesicle exocytosis (GO:0016079) | 3.48982560 |
76 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.47066749 |
77 | glutamate secretion (GO:0014047) | 3.40849667 |
78 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.37484870 |
79 | neuronal ion channel clustering (GO:0045161) | 3.36814076 |
80 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.35523929 |
81 | protein K11-linked deubiquitination (GO:0035871) | 3.33800746 |
82 | regulation of interleukin-13 production (GO:0032656) | 3.33766401 |
83 | membrane depolarization during action potential (GO:0086010) | 3.31722409 |
84 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.29290538 |
85 | meiosis I (GO:0007127) | 3.27391415 |
86 | glycolytic process (GO:0006096) | 3.27355229 |
87 | sexual reproduction (GO:0019953) | 3.26782979 |
88 | centriole replication (GO:0007099) | 3.26736973 |
89 | histone H3-K9 demethylation (GO:0033169) | 3.25781614 |
90 | chaperone-mediated protein complex assembly (GO:0051131) | 3.25293322 |
91 | calcium ion import (GO:0070509) | 3.23198864 |
92 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.21833200 |
93 | regulation of phosphoprotein phosphatase activity (GO:0043666) | 3.21108043 |
94 | regulation of spindle checkpoint (GO:0090231) | 3.11285683 |
95 | cell-cell junction maintenance (GO:0045217) | 3.10993461 |
96 | negative regulation of gene expression, epigenetic (GO:0045814) | 3.09308457 |
97 | microtubule polymerization or depolymerization (GO:0031109) | 3.08934218 |
98 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.06408076 |
99 | protein depolymerization (GO:0051261) | 3.06113497 |
100 | actin filament capping (GO:0051693) | 3.06087817 |
101 | ketone body metabolic process (GO:1902224) | 3.01868099 |
102 | dendritic spine organization (GO:0097061) | 3.01481541 |
103 | cellular response to pH (GO:0071467) | 3.00620885 |
104 | RNA localization (GO:0006403) | 2.99547643 |
105 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.98674649 |
106 | sequestering of actin monomers (GO:0042989) | 2.98572441 |
107 | multicellular organismal movement (GO:0050879) | 2.97836335 |
108 | musculoskeletal movement (GO:0050881) | 2.97836335 |
109 | microtubule-based movement (GO:0007018) | 2.96463884 |
110 | negative regulation of organelle assembly (GO:1902116) | 2.96382748 |
111 | cilium organization (GO:0044782) | 2.95985221 |
112 | regulation of somitogenesis (GO:0014807) | 2.95007051 |
113 | lactate metabolic process (GO:0006089) | 2.93701789 |
114 | mitotic G1 DNA damage checkpoint (GO:0031571) | 2.92084344 |
115 | intraciliary transport (GO:0042073) | 2.90902059 |
116 | positive regulation of synapse maturation (GO:0090129) | 2.89460473 |
117 | protein refolding (GO:0042026) | 2.86946765 |
118 | face development (GO:0060324) | 2.86715799 |
119 | receptor recycling (GO:0001881) | 2.84862510 |
120 | synaptic vesicle maturation (GO:0016188) | 2.84668371 |
121 | cilium assembly (GO:0042384) | 2.84434443 |
122 | regulation of synaptic vesicle transport (GO:1902803) | 2.83585852 |
123 | axoneme assembly (GO:0035082) | 2.81391979 |
124 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.78380507 |
125 | detection of light stimulus involved in visual perception (GO:0050908) | 2.78380507 |
126 | vesicle transport along microtubule (GO:0047496) | 2.77927624 |
127 | RNA destabilization (GO:0050779) | 2.77649657 |
128 | nucleosome disassembly (GO:0006337) | 2.76656592 |
129 | protein-DNA complex disassembly (GO:0032986) | 2.76656592 |
130 | cellular component assembly involved in morphogenesis (GO:0010927) | 2.75482343 |
131 | amino-acid betaine transport (GO:0015838) | 2.72827975 |
132 | carnitine transport (GO:0015879) | 2.72827975 |
133 | regulation of cilium assembly (GO:1902017) | 2.72589544 |
134 | meiotic cell cycle (GO:0051321) | 2.72224826 |
135 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.71264254 |
136 | urinary tract smooth muscle contraction (GO:0014848) | 2.70599225 |
137 | genitalia morphogenesis (GO:0035112) | 2.70163929 |
138 | response to acidic pH (GO:0010447) | 2.67619414 |
139 | cilium morphogenesis (GO:0060271) | 2.67474779 |
140 | nucleus organization (GO:0006997) | 2.67360981 |
141 | mitotic sister chromatid cohesion (GO:0007064) | 2.62090410 |
142 | carnitine transmembrane transport (GO:1902603) | 2.59659709 |
143 | regulation of acrosome reaction (GO:0060046) | 2.57560886 |
144 | positive regulation of macrophage activation (GO:0043032) | 2.54190349 |
145 | polyol catabolic process (GO:0046174) | 2.47268808 |
146 | interferon-gamma secretion (GO:0072643) | 2.46097615 |
147 | peptidyl-glutamic acid modification (GO:0018200) | 2.42756735 |
148 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.40515603 |
149 | sperm motility (GO:0030317) | 12.6583142 |
150 | fusion of sperm to egg plasma membrane (GO:0007342) | 11.6122084 |
151 | cell wall macromolecule catabolic process (GO:0016998) | 11.5948555 |
152 | cell wall macromolecule metabolic process (GO:0044036) | 11.5948555 |
153 | acrosome reaction (GO:0007340) | 11.5652589 |
154 | acrosome assembly (GO:0001675) | 10.3529942 |
155 | sperm-egg recognition (GO:0035036) | 10.3300489 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 6.97859098 |
2 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.29172568 |
3 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 4.27978836 |
4 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.06274411 |
5 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 3.99948403 |
6 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.21332468 |
7 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.99399389 |
8 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.49736825 |
9 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.49051301 |
10 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.42492527 |
11 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.37745536 |
12 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.37323584 |
13 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.31800267 |
14 | * CTCF_27219007_Chip-Seq_Bcells_Human | 2.24058565 |
15 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 2.22058329 |
16 | SMC4_20622854_ChIP-Seq_HELA_Human | 2.18106101 |
17 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.17265004 |
18 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.09311468 |
19 | P68_20966046_ChIP-Seq_HELA_Human | 2.03860412 |
20 | VDR_22108803_ChIP-Seq_LS180_Human | 2.02213637 |
21 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.94976992 |
22 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.94606568 |
23 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.92219109 |
24 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.73181769 |
25 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.69845502 |
26 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.68499101 |
27 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.66212232 |
28 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.63848553 |
29 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.63534110 |
30 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.62584504 |
31 | ERA_21632823_ChIP-Seq_H3396_Human | 1.62534193 |
32 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.60539887 |
33 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.60502574 |
34 | KDM2B_26808549_Chip-Seq_K562_Human | 1.60492525 |
35 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.59411163 |
36 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.58903361 |
37 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.55346460 |
38 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.55346460 |
39 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.55097406 |
40 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.54786887 |
41 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.52488641 |
42 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.52411607 |
43 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.51183678 |
44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.50786725 |
45 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.50624998 |
46 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.49174847 |
47 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.49116368 |
48 | * CTCF_20526341_ChIP-Seq_ESCs_Human | 1.47623724 |
49 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.46858401 |
50 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.45651815 |
51 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.44799721 |
52 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.44514948 |
53 | KDM2B_26808549_Chip-Seq_REH_Human | 1.43979309 |
54 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.43891803 |
55 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.43423378 |
56 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.42474965 |
57 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.40522552 |
58 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.40522552 |
59 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.40421386 |
60 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.38440946 |
61 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.38102376 |
62 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.37669119 |
63 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.35916546 |
64 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.34756490 |
65 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.34739071 |
66 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.34213087 |
67 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.34191348 |
68 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.33862947 |
69 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.33801146 |
70 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.32328345 |
71 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.32135431 |
72 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.32042252 |
73 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.31905579 |
74 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.30924856 |
75 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.30885074 |
76 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.30195502 |
77 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.27801641 |
78 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.26231624 |
79 | * SA1_27219007_Chip-Seq_Bcells_Human | 1.25690189 |
80 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.24512322 |
81 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.24194135 |
82 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.24190606 |
83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.24180401 |
84 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.24180401 |
85 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.23051650 |
86 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.23001362 |
87 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.22957470 |
88 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.22826912 |
89 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.22220953 |
90 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.21481232 |
91 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.21137727 |
92 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.19290356 |
93 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.18781775 |
94 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.18667857 |
95 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.18430785 |
96 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.18138869 |
97 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.17876859 |
98 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 1.17674173 |
99 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.17035677 |
100 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.16752917 |
101 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.15992622 |
102 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.14440486 |
103 | GF1_26923725_Chip-Seq_HPCs_Mouse | 1.14126919 |
104 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.12860291 |
105 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.12463434 |
106 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.11720467 |
107 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.11650116 |
108 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.11558549 |
109 | KLF4_19829295_ChIP-Seq_ESCs_Human | 1.11451960 |
110 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 1.11386804 |
111 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.10437173 |
112 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.10270001 |
113 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.09393954 |
114 | P300_27268052_Chip-Seq_Bcells_Human | 1.09109085 |
115 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.08885605 |
116 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.07705923 |
117 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.07688892 |
118 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.07621922 |
119 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.07341606 |
120 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.06424002 |
121 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.05575445 |
122 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.05265545 |
123 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.05203688 |
124 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.04757770 |
125 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.04546406 |
126 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.04318956 |
127 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03949966 |
128 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.03181103 |
129 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.01490262 |
130 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.01099009 |
131 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.01067672 |
132 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 1.00844526 |
133 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.00313611 |
134 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.00084152 |
135 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.00039296 |
136 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.00006549 |
137 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.00000598 |
138 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.99718537 |
139 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.99408705 |
140 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.99214584 |
141 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.98076632 |
142 | CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.97953464 |
143 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97820409 |
144 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.96687283 |
145 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 0.96334909 |
146 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.96091712 |
147 | FUS_26573619_Chip-Seq_HEK293_Human | 0.95886557 |
148 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.95514435 |
149 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.95252657 |
150 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.95123283 |
151 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.94959660 |
152 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.94952848 |
153 | KLF5_25053715_ChIP-Seq_YYC3_Human | 0.94783119 |
154 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.93967895 |
155 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.93029578 |
156 | TCF4_23295773_ChIP-Seq_U87_Human | 0.92460269 |
157 | TBL1_22424771_ChIP-Seq_293T_Human | 0.92104308 |
158 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.91879096 |
159 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.91161791 |
160 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.90799314 |
161 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90466695 |
162 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.90297808 |
163 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.90105969 |
164 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.89936541 |
165 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.88902565 |
166 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.88782484 |
167 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.88157795 |
168 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.87756417 |
169 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.86850124 |
170 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.86129750 |
171 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.85761757 |
172 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.85537259 |
173 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.85355305 |
174 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.84534739 |
175 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.84049183 |
176 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.83534909 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003698_abnormal_male_reproductive | 5.21785946 |
2 | MP0001929_abnormal_gametogenesis | 4.57256979 |
3 | MP0003878_abnormal_ear_physiology | 4.01609112 |
4 | MP0005377_hearing/vestibular/ear_phenot | 4.01609112 |
5 | MP0008877_abnormal_DNA_methylation | 3.31444588 |
6 | MP0000678_abnormal_parathyroid_gland | 2.98557576 |
7 | MP0002161_abnormal_fertility/fecundity | 2.78518951 |
8 | MP0002210_abnormal_sex_determination | 2.66334717 |
9 | MP0002249_abnormal_larynx_morphology | 2.61566955 |
10 | MP0005670_abnormal_white_adipose | 2.54745363 |
11 | MP0001145_abnormal_male_reproductive | 2.30985201 |
12 | MP0005551_abnormal_eye_electrophysiolog | 2.19917084 |
13 | MP0001984_abnormal_olfaction | 2.16669657 |
14 | MP0004859_abnormal_synaptic_plasticity | 2.16657643 |
15 | MP0002132_abnormal_respiratory_system | 2.14750781 |
16 | MP0003880_abnormal_central_pattern | 2.10441665 |
17 | MP0009046_muscle_twitch | 2.07401542 |
18 | MP0004233_abnormal_muscle_weight | 2.00102471 |
19 | MP0005410_abnormal_fertilization | 13.9738706 |
20 | MP0000653_abnormal_sex_gland | 1.98807874 |
21 | MP0005423_abnormal_somatic_nervous | 1.75320335 |
22 | MP0002653_abnormal_ependyma_morphology | 1.73404160 |
23 | MP0003635_abnormal_synaptic_transmissio | 1.64173465 |
24 | MP0005623_abnormal_meninges_morphology | 1.52767323 |
25 | MP0005248_abnormal_Harderian_gland | 1.52554858 |
26 | MP0004510_myositis | 1.51992505 |
27 | MP0000681_abnormal_thyroid_gland | 1.51125185 |
28 | MP0004270_analgesia | 1.41859603 |
29 | MP0001486_abnormal_startle_reflex | 1.39105316 |
30 | MP0009745_abnormal_behavioral_response | 1.38675482 |
31 | MP0002822_catalepsy | 1.36759155 |
32 | MP0001968_abnormal_touch/_nociception | 1.36027545 |
33 | MP0002736_abnormal_nociception_after | 1.35802435 |
34 | MP0002063_abnormal_learning/memory/cond | 1.34785086 |
35 | MP0002160_abnormal_reproductive_system | 1.34695442 |
36 | MP0003646_muscle_fatigue | 1.30938835 |
37 | MP0005253_abnormal_eye_physiology | 1.29649327 |
38 | MP0002064_seizures | 1.27807718 |
39 | MP0002572_abnormal_emotion/affect_behav | 1.25898842 |
40 | MP0003011_delayed_dark_adaptation | 1.25342715 |
41 | MP0002272_abnormal_nervous_system | 1.24167957 |
42 | MP0001849_ear_inflammation | 1.22083577 |
43 | MP0006072_abnormal_retinal_apoptosis | 1.21915663 |
44 | MP0001485_abnormal_pinna_reflex | 1.14455581 |
45 | MP0005409_darkened_coat_color | 1.13014094 |
46 | MP0002127_abnormal_cardiovascular_syste | 1.11219281 |
47 | MP0001501_abnormal_sleep_pattern | 1.10960703 |
48 | MP0003787_abnormal_imprinting | 1.08897273 |
49 | MP0001963_abnormal_hearing_physiology | 1.08445924 |
50 | MP0002734_abnormal_mechanical_nocicepti | 1.04688596 |
51 | MP0001529_abnormal_vocalization | 1.02458521 |
52 | MP0004811_abnormal_neuron_physiology | 1.01216335 |
53 | MP0003950_abnormal_plasma_membrane | 1.00942439 |
54 | MP0003718_maternal_effect | 1.00522561 |
55 | MP0008569_lethality_at_weaning | 0.98301781 |
56 | MP0001765_abnormal_ion_homeostasis | 0.97402754 |
57 | MP0002735_abnormal_chemical_nociception | 0.95394261 |
58 | MP0002234_abnormal_pharynx_morphology | 0.94722521 |
59 | MP0005310_abnormal_salivary_gland | 0.92776979 |
60 | MP0001502_abnormal_circadian_rhythm | 0.91379650 |
61 | MP0000566_synostosis | 0.90780041 |
62 | MP0003705_abnormal_hypodermis_morpholog | 0.90235673 |
63 | MP0000026_abnormal_inner_ear | 0.90067114 |
64 | MP0005195_abnormal_posterior_eye | 0.89668542 |
65 | MP0001348_abnormal_lacrimal_gland | 0.88478381 |
66 | MP0005499_abnormal_olfactory_system | 0.87783566 |
67 | MP0005394_taste/olfaction_phenotype | 0.87783566 |
68 | MP0001324_abnormal_eye_pigmentation | 0.85749559 |
69 | MP0004036_abnormal_muscle_relaxation | 0.85258861 |
70 | MP0002928_abnormal_bile_duct | 0.83774714 |
71 | MP0002229_neurodegeneration | 0.82234310 |
72 | MP0001440_abnormal_grooming_behavior | 0.79811146 |
73 | MP0002067_abnormal_sensory_capabilities | 0.79640685 |
74 | MP0003329_amyloid_beta_deposits | 0.78842409 |
75 | MP0003633_abnormal_nervous_system | 0.78346466 |
76 | MP0002882_abnormal_neuron_morphology | 0.77676847 |
77 | MP0001188_hyperpigmentation | 0.77342391 |
78 | MP0000049_abnormal_middle_ear | 0.76193676 |
79 | MP0001270_distended_abdomen | 0.75761295 |
80 | MP0005647_abnormal_sex_gland | 0.75529880 |
81 | MP0009780_abnormal_chondrocyte_physiolo | 0.74578036 |
82 | MP0002557_abnormal_social/conspecific_i | 0.73615038 |
83 | MP0003632_abnormal_nervous_system | 0.72424495 |
84 | MP0000569_abnormal_digit_pigmentation | 0.72312543 |
85 | MP0001299_abnormal_eye_distance/ | 0.72062425 |
86 | MP0002909_abnormal_adrenal_gland | 0.71510550 |
87 | MP0001905_abnormal_dopamine_level | 0.70522447 |
88 | MP0002152_abnormal_brain_morphology | 0.69937920 |
89 | MP0000003_abnormal_adipose_tissue | 0.69146902 |
90 | MP0004085_abnormal_heartbeat | 0.68217931 |
91 | MP0002090_abnormal_vision | 0.67650010 |
92 | MP0003631_nervous_system_phenotype | 0.66876648 |
93 | MP0001970_abnormal_pain_threshold | 0.66304491 |
94 | MP0004742_abnormal_vestibular_system | 0.66023129 |
95 | MP0009053_abnormal_anal_canal | 0.65114188 |
96 | MP0003091_abnormal_cell_migration | 0.63827612 |
97 | MP0000955_abnormal_spinal_cord | 0.63627890 |
98 | MP0003634_abnormal_glial_cell | 0.63142420 |
99 | MP0002752_abnormal_somatic_nervous | 0.63018750 |
100 | MP0005167_abnormal_blood-brain_barrier | 0.62754764 |
101 | MP0003879_abnormal_hair_cell | 0.62499074 |
102 | MP0002066_abnormal_motor_capabilities/c | 0.61898833 |
103 | MP0005391_vision/eye_phenotype | 0.61336603 |
104 | MP0002184_abnormal_innervation | 0.60541134 |
105 | MP0003119_abnormal_digestive_system | 0.60503132 |
106 | MP0000778_abnormal_nervous_system | 0.59867912 |
107 | MP0003385_abnormal_body_wall | 0.58332001 |
108 | MP0005083_abnormal_biliary_tract | 0.58065504 |
109 | MP0005389_reproductive_system_phenotype | 0.57505197 |
110 | MP0000920_abnormal_myelination | 0.56913753 |
111 | MP0003115_abnormal_respiratory_system | 0.56475427 |
112 | MP0008995_early_reproductive_senescence | 0.56358683 |
113 | MP0000579_abnormal_nail_morphology | 0.55546368 |
114 | MP0000534_abnormal_ureter_morphology | 0.55482682 |
115 | MP0002138_abnormal_hepatobiliary_system | 0.54719883 |
116 | MP0000751_myopathy | 0.54467240 |
117 | MP0008874_decreased_physiological_sensi | 0.53157081 |
118 | MP0004924_abnormal_behavior | 0.52938672 |
119 | MP0005386_behavior/neurological_phenoty | 0.52938672 |
120 | MP0002733_abnormal_thermal_nociception | 0.52834547 |
121 | MP0002282_abnormal_trachea_morphology | 0.52286691 |
122 | MP0005646_abnormal_pituitary_gland | 0.51918378 |
123 | MP0003942_abnormal_urinary_system | 0.50382831 |
124 | MP0008961_abnormal_basal_metabolism | 0.49991451 |
125 | MP0006292_abnormal_olfactory_placode | 0.49857788 |
126 | MP0001346_abnormal_lacrimal_gland | 0.48373475 |
127 | MP0003172_abnormal_lysosome_physiology | 0.48297824 |
128 | MP0000163_abnormal_cartilage_morphology | 0.47150927 |
129 | MP0003861_abnormal_nervous_system | 0.46492018 |
130 | MP0003183_abnormal_peptide_metabolism | 0.46450073 |
131 | MP0006276_abnormal_autonomic_nervous | 0.45917527 |
132 | MP0000631_abnormal_neuroendocrine_gland | 0.45212914 |
133 | MP0006035_abnormal_mitochondrial_morpho | 0.44128529 |
134 | MP0004133_heterotaxia | 0.43818317 |
135 | MP0004145_abnormal_muscle_electrophysio | 0.43506201 |
136 | MP0010386_abnormal_urinary_bladder | 0.40930894 |
137 | MP0008872_abnormal_physiological_respon | 0.40859303 |
138 | MP0000358_abnormal_cell_content/ | 0.40065363 |
139 | MP0002269_muscular_atrophy | 0.39040878 |
140 | MP0006036_abnormal_mitochondrial_physio | 0.37504696 |
141 | MP0004084_abnormal_cardiac_muscle | 0.36668397 |
142 | MP0001986_abnormal_taste_sensitivity | 0.36262845 |
143 | MP0005666_abnormal_adipose_tissue | 0.36116967 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormal respiratory motile cilium physiology (HP:0012261) | 8.37186869 |
2 | Abnormal respiratory motile cilium morphology (HP:0005938) | 8.19723937 |
3 | Abnormal respiratory epithelium morphology (HP:0012253) | 8.19723937 |
4 | Rhinitis (HP:0012384) | 6.75936339 |
5 | Abnormal ciliary motility (HP:0012262) | 6.61431670 |
6 | Chronic bronchitis (HP:0004469) | 6.31223624 |
7 | Infertility (HP:0000789) | 6.15161308 |
8 | Nasal polyposis (HP:0100582) | 5.17615943 |
9 | Resting tremor (HP:0002322) | 4.73793559 |
10 | Nephronophthisis (HP:0000090) | 4.40266203 |
11 | Asymmetric septal hypertrophy (HP:0001670) | 4.19971341 |
12 | Abnormality of the nasal mucosa (HP:0000433) | 4.09664543 |
13 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 4.06735799 |
14 | Hypoplastic ischia (HP:0003175) | 4.04061508 |
15 | Male infertility (HP:0003251) | 3.88960308 |
16 | Bronchiectasis (HP:0002110) | 3.80040197 |
17 | Bronchitis (HP:0012387) | 3.77848613 |
18 | Enlarged epiphyses (HP:0010580) | 3.76521531 |
19 | Abnormality of the ischium (HP:0003174) | 3.71003413 |
20 | Abnormality of the aortic arch (HP:0012303) | 3.33085059 |
21 | Abnormality of the renal medulla (HP:0100957) | 3.24615150 |
22 | Dyschromatopsia (HP:0007641) | 3.15780639 |
23 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 3.14697281 |
24 | Medial flaring of the eyebrow (HP:0010747) | 3.03029816 |
25 | Recurrent otitis media (HP:0000403) | 3.00646571 |
26 | Abnormal gallbladder physiology (HP:0012438) | 2.99715081 |
27 | Cholecystitis (HP:0001082) | 2.99715081 |
28 | Recurrent sinusitis (HP:0011108) | 2.91241495 |
29 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.89712108 |
30 | Decreased central vision (HP:0007663) | 2.86725540 |
31 | Abnormality of midbrain morphology (HP:0002418) | 2.84452338 |
32 | Molar tooth sign on MRI (HP:0002419) | 2.84452338 |
33 | Atonic seizures (HP:0010819) | 2.80149823 |
34 | Abnormal spermatogenesis (HP:0008669) | 2.79483223 |
35 | Chronic hepatic failure (HP:0100626) | 2.62845760 |
36 | Epiphyseal dysplasia (HP:0002656) | 2.54352790 |
37 | Tubulointerstitial nephritis (HP:0001970) | 2.51894205 |
38 | Facial shape deformation (HP:0011334) | 2.48814441 |
39 | Potter facies (HP:0002009) | 2.48814441 |
40 | Bowel incontinence (HP:0002607) | 2.47968311 |
41 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.44373303 |
42 | Genetic anticipation (HP:0003743) | 2.40620775 |
43 | Hypoplasia of the thymus (HP:0000778) | 2.40479005 |
44 | Choroideremia (HP:0001139) | 2.40197417 |
45 | Renovascular hypertension (HP:0100817) | 2.38910533 |
46 | Obstructive sleep apnea (HP:0002870) | 2.36232540 |
47 | Urethral obstruction (HP:0000796) | 2.35903416 |
48 | Tubular atrophy (HP:0000092) | 2.33216406 |
49 | Congenital stationary night blindness (HP:0007642) | 2.31358586 |
50 | Tubulointerstitial abnormality (HP:0001969) | 2.30791684 |
51 | Hyperthyroidism (HP:0000836) | 2.30758976 |
52 | Peripheral hypomyelination (HP:0007182) | 2.29129705 |
53 | Focal motor seizures (HP:0011153) | 2.26763007 |
54 | Amblyopia (HP:0000646) | 2.25877543 |
55 | Mixed hearing impairment (HP:0000410) | 2.24585542 |
56 | Flattened epiphyses (HP:0003071) | 2.22629874 |
57 | Stereotypic behavior (HP:0000733) | 2.22135783 |
58 | Truncal obesity (HP:0001956) | 2.17563311 |
59 | Gonadotropin excess (HP:0000837) | 2.16190851 |
60 | Abnormal large intestine physiology (HP:0012700) | 2.15723175 |
61 | Atelectasis (HP:0100750) | 2.13320641 |
62 | Progressive cerebellar ataxia (HP:0002073) | 2.12741046 |
63 | Recurrent bronchitis (HP:0002837) | 2.08931939 |
64 | Impulsivity (HP:0100710) | 2.08131029 |
65 | Neurofibrillary tangles (HP:0002185) | 2.06576807 |
66 | Abnormality of the lower motor neuron (HP:0002366) | 2.05336592 |
67 | Congenital malformation of the right heart (HP:0011723) | 2.02884747 |
68 | Double outlet right ventricle (HP:0001719) | 2.02884747 |
69 | Hemiparesis (HP:0001269) | 2.01736043 |
70 | Hypoalphalipoproteinemia (HP:0003233) | 2.00957652 |
71 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 12.2223066 |
72 | Absent/shortened dynein arms (HP:0200106) | 12.2223066 |
73 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 11.6879378 |
74 | Cerebral hypomyelination (HP:0006808) | 1.99856393 |
75 | Dysmetria (HP:0001310) | 1.98766554 |
76 | Focal seizures (HP:0007359) | 1.98600381 |
77 | Central scotoma (HP:0000603) | 1.96338206 |
78 | Unilateral renal agenesis (HP:0000122) | 1.95870718 |
79 | Annular pancreas (HP:0001734) | 1.94598060 |
80 | Febrile seizures (HP:0002373) | 1.93914765 |
81 | Tubulointerstitial fibrosis (HP:0005576) | 1.93707339 |
82 | Broad face (HP:0000283) | 1.92155892 |
83 | Hypoparathyroidism (HP:0000829) | 1.91481350 |
84 | Abnormality of the pubic bones (HP:0003172) | 1.91007314 |
85 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.90602973 |
86 | Spastic tetraparesis (HP:0001285) | 1.89948107 |
87 | Action tremor (HP:0002345) | 1.89905753 |
88 | Progressive sensorineural hearing impairment (HP:0000408) | 1.88188992 |
89 | Atrophic scars (HP:0001075) | 1.86352857 |
90 | Gait imbalance (HP:0002141) | 1.85739285 |
91 | Bradykinesia (HP:0002067) | 1.85722897 |
92 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.85530465 |
93 | Cone-rod dystrophy (HP:0000548) | 1.84823371 |
94 | Cerebral inclusion bodies (HP:0100314) | 1.82006915 |
95 | Epileptic encephalopathy (HP:0200134) | 1.81874446 |
96 | Delusions (HP:0000746) | 1.81569781 |
97 | Sensory axonal neuropathy (HP:0003390) | 1.80731561 |
98 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.79864972 |
99 | Supranuclear gaze palsy (HP:0000605) | 1.79780187 |
100 | Bradycardia (HP:0001662) | 1.79643282 |
101 | Postaxial foot polydactyly (HP:0001830) | 1.77953894 |
102 | Abnormality of the epiphysis of the femoral head (HP:0010574) | 1.77485465 |
103 | Congenital primary aphakia (HP:0007707) | 1.77256051 |
104 | Vertebral clefting (HP:0008428) | 1.76649724 |
105 | Congenital hepatic fibrosis (HP:0002612) | 1.74326016 |
106 | Abnormality of the parathyroid morphology (HP:0011766) | 1.73999159 |
107 | Heterotopia (HP:0002282) | 1.73470959 |
108 | Abnormality of macular pigmentation (HP:0008002) | 1.72889499 |
109 | Amelogenesis imperfecta (HP:0000705) | 1.72173757 |
110 | Abnormality of femoral epiphyses (HP:0006499) | 1.72161549 |
111 | Abnormality involving the epiphyses of the lower limbs (HP:0006500) | 1.72161549 |
112 | Papilledema (HP:0001085) | 1.71834503 |
113 | Colitis (HP:0002583) | 1.71416585 |
114 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.70828309 |
115 | Ventricular tachycardia (HP:0004756) | 1.69867048 |
116 | Attenuation of retinal blood vessels (HP:0007843) | 1.69641332 |
117 | Underdeveloped nasal alae (HP:0000430) | 1.69605017 |
118 | Truncus arteriosus (HP:0001660) | 1.69094394 |
119 | Hand muscle atrophy (HP:0009130) | 1.68110674 |
120 | Abnormal drinking behavior (HP:0030082) | 1.68046797 |
121 | Polydipsia (HP:0001959) | 1.68046797 |
122 | Azoospermia (HP:0000027) | 1.67403382 |
123 | Stage 5 chronic kidney disease (HP:0003774) | 1.66606698 |
124 | Neoplasm of striated muscle (HP:0009728) | 1.66513259 |
125 | Oculomotor apraxia (HP:0000657) | 1.65969546 |
126 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.63571353 |
127 | Exercise-induced myalgia (HP:0003738) | 1.63251316 |
128 | Visual hallucinations (HP:0002367) | 1.62651976 |
129 | Distal upper limb amyotrophy (HP:0007149) | 1.62396535 |
130 | Upper limb amyotrophy (HP:0009129) | 1.62396535 |
131 | Abnormality of dental color (HP:0011073) | 1.62171051 |
132 | Postaxial hand polydactyly (HP:0001162) | 1.61022414 |
133 | Ankle clonus (HP:0011448) | 1.59635125 |
134 | Bile duct proliferation (HP:0001408) | 1.57941984 |
135 | Abnormal biliary tract physiology (HP:0012439) | 1.57941984 |
136 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.56088411 |
137 | Myokymia (HP:0002411) | 1.55511128 |
138 | Nephrogenic diabetes insipidus (HP:0009806) | 1.53878842 |
139 | Constricted visual fields (HP:0001133) | 1.52668507 |
140 | Retinal dysplasia (HP:0007973) | 1.49138729 |
141 | Absent epiphyses (HP:0010577) | 1.46799691 |
142 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.46799691 |
143 | Vaginal atresia (HP:0000148) | 1.46791792 |
144 | Genital tract atresia (HP:0001827) | 1.46687920 |
145 | Amyotrophic lateral sclerosis (HP:0007354) | 1.46484317 |
146 | Renal dysplasia (HP:0000110) | 1.45919608 |
147 | Gaze-evoked nystagmus (HP:0000640) | 1.45602493 |
148 | Postural instability (HP:0002172) | 1.44959408 |
149 | Spastic gait (HP:0002064) | 1.44797964 |
150 | Abnormality of saccadic eye movements (HP:0000570) | 1.44167844 |
151 | Hyperkalemia (HP:0002153) | 1.42240917 |
152 | Fibular hypoplasia (HP:0003038) | 1.42114917 |
153 | Bell-shaped thorax (HP:0001591) | 1.41716508 |
154 | Neoplasm of the heart (HP:0100544) | 1.41479581 |
155 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.41379632 |
156 | Poor coordination (HP:0002370) | 1.40464802 |
157 | Short ribs (HP:0000773) | 1.38604557 |
158 | Severe visual impairment (HP:0001141) | 1.38040221 |
159 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.37633273 |
160 | Pachygyria (HP:0001302) | 1.37514639 |
161 | Type II diabetes mellitus (HP:0005978) | 1.37358250 |
162 | J-shaped sella turcica (HP:0002680) | 1.35881152 |
163 | Deformed sella turcica (HP:0002681) | 1.35280569 |
164 | Bundle branch block (HP:0011710) | 1.34694010 |
165 | Pancreatic fibrosis (HP:0100732) | 1.34512396 |
166 | Abnormality of renal excretion (HP:0011036) | 1.33794589 |
167 | Lower limb muscle weakness (HP:0007340) | 1.31829755 |
168 | Taurodontia (HP:0000679) | 1.31363796 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PDK3 | 6.64331607 |
2 | PDK4 | 6.64331607 |
3 | PRKD3 | 6.38695202 |
4 | TESK1 | 6.30699768 |
5 | PLK4 | 5.23995679 |
6 | ICK | 4.48258314 |
7 | DDR2 | 4.26253693 |
8 | PDK2 | 4.07568766 |
9 | PTK2B | 2.53741448 |
10 | PNCK | 2.49342094 |
11 | INSRR | 2.23573548 |
12 | STK38 | 2.21675170 |
13 | CDK12 | 2.19015425 |
14 | BRD4 | 2.14823653 |
15 | MST1R | 2.00956137 |
16 | STK39 | 1.93689878 |
17 | WNK4 | 1.76667520 |
18 | LATS2 | 1.61880366 |
19 | NEK2 | 1.60089000 |
20 | TRIB3 | 1.48947596 |
21 | UHMK1 | 1.43369216 |
22 | STK38L | 1.38390735 |
23 | DYRK1B | 1.38190689 |
24 | NLK | 1.36346061 |
25 | CDK3 | 1.24833529 |
26 | CAMK1G | 1.24211308 |
27 | TESK2 | 1.22698221 |
28 | PDK1 | 1.19520718 |
29 | TYRO3 | 1.18549633 |
30 | MAP4K2 | 1.09089956 |
31 | NTRK3 | 1.06117834 |
32 | RIPK4 | 0.98621497 |
33 | AKT3 | 0.98439092 |
34 | PINK1 | 0.93597420 |
35 | ARAF | 0.93184596 |
36 | RPS6KA2 | 0.91197094 |
37 | MAP3K4 | 0.89775704 |
38 | NTRK2 | 0.87842205 |
39 | PAK6 | 0.87669708 |
40 | EPHA4 | 0.85185256 |
41 | MARK1 | 0.84056775 |
42 | PDPK1 | 0.82931403 |
43 | LMTK2 | 0.82011079 |
44 | CAMK4 | 0.81299713 |
45 | WNK1 | 0.77671943 |
46 | PRKG2 | 0.76455976 |
47 | CDK7 | 0.75757721 |
48 | LATS1 | 0.75048986 |
49 | MAP3K13 | 0.73054458 |
50 | PRKCG | 0.73002684 |
51 | TNK2 | 0.68013268 |
52 | BRAF | 0.66988723 |
53 | MAP2K7 | 0.66211930 |
54 | MAP3K11 | 0.65310147 |
55 | CAMKK1 | 0.65271150 |
56 | MINK1 | 0.64550469 |
57 | PKN1 | 0.63283584 |
58 | CDK19 | 0.60737533 |
59 | MARK2 | 0.59862444 |
60 | ROCK1 | 0.56334810 |
61 | CDK4 | 0.55074339 |
62 | RPS6KA1 | 0.54814181 |
63 | SGK1 | 0.54693890 |
64 | SIK1 | 0.54065879 |
65 | CHEK2 | 0.53031193 |
66 | PRKCZ | 0.52247146 |
67 | MAP2K6 | 0.51691264 |
68 | IRAK1 | 0.49032445 |
69 | CDK15 | 0.48981586 |
70 | MAP3K2 | 0.48817288 |
71 | RPS6KL1 | 0.48204059 |
72 | RPS6KC1 | 0.48204059 |
73 | CDK5 | 0.47209364 |
74 | MET | 0.46626415 |
75 | MAPK13 | 0.46310781 |
76 | PRPF4B | 0.46293645 |
77 | CDK18 | 0.46042408 |
78 | MAPK1 | 0.44366862 |
79 | EEF2K | 0.43480912 |
80 | NTRK1 | 0.43343422 |
81 | CDC42BPA | 0.42240885 |
82 | PRKAA1 | 0.41768718 |
83 | MAP3K7 | 0.41651504 |
84 | RPS6KA6 | 0.41383682 |
85 | SGK223 | 0.41354975 |
86 | SGK494 | 0.41354975 |
87 | CDK14 | 0.40983072 |
88 | FGFR2 | 0.40809794 |
89 | MARK3 | 0.40782059 |
90 | NEK6 | 0.40363113 |
91 | FES | 0.40080030 |
92 | MAPK7 | 0.39503085 |
93 | PHKG1 | 0.38982793 |
94 | PHKG2 | 0.38982793 |
95 | CDK11A | 0.38876944 |
96 | MAP2K2 | 0.38793157 |
97 | CLK1 | 0.38745874 |
98 | CDK2 | 0.37315635 |
99 | MAPK15 | 0.36781887 |
100 | MAP3K10 | 0.36661082 |
101 | DYRK3 | 0.36531981 |
102 | GRK5 | 0.36211645 |
103 | DYRK1A | 0.35790756 |
104 | CAMK2A | 0.35625896 |
105 | PRKAA2 | 0.34985671 |
106 | MAP3K8 | 0.34493146 |
107 | RET | 0.34398225 |
108 | PAK1 | 0.33444970 |
109 | CHEK1 | 0.32962462 |
110 | IRAK2 | 0.32663902 |
111 | CDK1 | 0.31905490 |
112 | MAP2K4 | 0.30268958 |
113 | STK11 | 0.29863067 |
114 | CCNB1 | 0.27802107 |
115 | SGK2 | 0.25403264 |
116 | CAMK1 | 0.23104637 |
117 | SIK2 | 0.23087939 |
118 | PRKD2 | 0.22393768 |
119 | PRKCB | 0.21890363 |
120 | GSK3B | 0.21516250 |
121 | MTOR | 0.20608554 |
122 | PAK3 | 0.20484111 |
123 | MAP3K9 | 0.20060889 |
124 | ATM | 0.20011165 |
125 | STK3 | 0.19522242 |
126 | RIPK1 | 0.19307508 |
127 | RPS6KB1 | 0.19204829 |
128 | RPS6KA3 | 0.18445708 |
129 | MAPK10 | 0.17934738 |
130 | PRKCH | 0.17654234 |
131 | PRKCA | 0.17510456 |
132 | YES1 | 0.17469790 |
133 | MAPK8 | 0.17063060 |
134 | MAPKAPK5 | 0.16573271 |
135 | MAP3K1 | 0.16368196 |
136 | CAMK1D | 0.15661577 |
137 | PRKCQ | 0.15200577 |
138 | PRKG1 | 0.14700223 |
139 | KSR2 | 0.14482883 |
140 | TNIK | 0.14191089 |
141 | CASK | 0.14027312 |
142 | ATR | 0.13780595 |
143 | DAPK2 | 0.12506361 |
144 | MUSK | 0.12134091 |
145 | PLK2 | 0.12066713 |
146 | WNK3 | 0.11875653 |
147 | SGK3 | 0.11843555 |
148 | PRKACA | 0.11287847 |
149 | GRK1 | 0.10567054 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.62465375 |
2 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 3.32468870 |
3 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 3.17662357 |
4 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.58832653 |
5 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.54473877 |
6 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.43108729 |
7 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.36462024 |
8 | Nicotine addiction_Homo sapiens_hsa05033 | 2.32436518 |
9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.31932937 |
10 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 2.29886261 |
11 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.27553337 |
12 | Phototransduction_Homo sapiens_hsa04744 | 2.19845112 |
13 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 2.14376302 |
14 | Renin secretion_Homo sapiens_hsa04924 | 1.89746435 |
15 | Circadian entrainment_Homo sapiens_hsa04713 | 1.86873902 |
16 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.80363534 |
17 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.77032141 |
18 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.76344494 |
19 | Long-term potentiation_Homo sapiens_hsa04720 | 1.76039033 |
20 | Olfactory transduction_Homo sapiens_hsa04740 | 1.71293675 |
21 | Insulin secretion_Homo sapiens_hsa04911 | 1.70593944 |
22 | Salivary secretion_Homo sapiens_hsa04970 | 1.65092378 |
23 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.63740254 |
24 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.62909508 |
25 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.62863622 |
26 | Morphine addiction_Homo sapiens_hsa05032 | 1.54795998 |
27 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.54418186 |
28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.47986938 |
29 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.45027545 |
30 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.44837819 |
31 | GABAergic synapse_Homo sapiens_hsa04727 | 1.40490791 |
32 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.35483090 |
33 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.31225869 |
34 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.30816525 |
35 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.28693178 |
36 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.27885348 |
37 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.27330378 |
38 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.25643601 |
39 | Alcoholism_Homo sapiens_hsa05034 | 1.23152139 |
40 | Cocaine addiction_Homo sapiens_hsa05030 | 1.22753391 |
41 | Taste transduction_Homo sapiens_hsa04742 | 1.22442301 |
42 | Mineral absorption_Homo sapiens_hsa04978 | 1.18915931 |
43 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.17380470 |
44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.16795584 |
45 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.15631408 |
46 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.15058335 |
47 | Melanogenesis_Homo sapiens_hsa04916 | 1.12678987 |
48 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.03809599 |
49 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.02918145 |
50 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.00041712 |
51 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.99809595 |
52 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.98238250 |
53 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.97909931 |
54 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.95063384 |
55 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.93820280 |
56 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.91833637 |
57 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.91735794 |
58 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.91609896 |
59 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.90241821 |
60 | Glioma_Homo sapiens_hsa05214 | 0.89025381 |
61 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.87793775 |
62 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.87644967 |
63 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.86990083 |
64 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.82280800 |
65 | Basal transcription factors_Homo sapiens_hsa03022 | 0.81168271 |
66 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.80290081 |
67 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.79553284 |
68 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.78151260 |
69 | Huntingtons disease_Homo sapiens_hsa05016 | 0.77978243 |
70 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.76296890 |
71 | Tight junction_Homo sapiens_hsa04530 | 0.75960075 |
72 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.75825586 |
73 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.74353550 |
74 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.73877946 |
75 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.73688255 |
76 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.73464079 |
77 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.72406514 |
78 | Endocytosis_Homo sapiens_hsa04144 | 0.68550379 |
79 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67130271 |
80 | Purine metabolism_Homo sapiens_hsa00230 | 0.65425072 |
81 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.65108134 |
82 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.65013966 |
83 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.64137503 |
84 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.63277449 |
85 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.62566561 |
86 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.61337164 |
87 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.60950162 |
88 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.59994012 |
89 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.59758330 |
90 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.59379563 |
91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.58583070 |
92 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.58555074 |
93 | Adherens junction_Homo sapiens_hsa04520 | 0.57938332 |
94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.55849009 |
95 | Bile secretion_Homo sapiens_hsa04976 | 0.55785692 |
96 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.55507034 |
97 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.54425948 |
98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.53357689 |
99 | Endometrial cancer_Homo sapiens_hsa05213 | 0.53313827 |
100 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.53252948 |
101 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.51098635 |
102 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.50856647 |
103 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.50296658 |
104 | ABC transporters_Homo sapiens_hsa02010 | 0.48883205 |
105 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.48197343 |
106 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.48001991 |
107 | Long-term depression_Homo sapiens_hsa04730 | 0.47938081 |
108 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.47285728 |
109 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.46783366 |
110 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.46536187 |
111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.46461916 |
112 | Focal adhesion_Homo sapiens_hsa04510 | 0.45235152 |
113 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.44970114 |
114 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.43633208 |
115 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.43436191 |
116 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.42889769 |
117 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.42598163 |
118 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.40285717 |
119 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.40236375 |
120 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.38822201 |
121 | Thyroid cancer_Homo sapiens_hsa05216 | 0.38619397 |
122 | Circadian rhythm_Homo sapiens_hsa04710 | 0.38203501 |
123 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.38065590 |
124 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.36958651 |
125 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.36916155 |
126 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.36874021 |
127 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.36113306 |
128 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.35969494 |
129 | Axon guidance_Homo sapiens_hsa04360 | 0.31728748 |
130 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.28116154 |
131 | Gap junction_Homo sapiens_hsa04540 | 0.27919046 |
132 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.25651772 |
133 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.23922195 |