TRIM17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.40695043
2binding of sperm to zona pellucida (GO:0007339)9.39134856
3cell-cell recognition (GO:0009988)9.28478560
4plasma membrane fusion (GO:0045026)9.12952566
5axonemal dynein complex assembly (GO:0070286)8.88099871
6epithelial cilium movement (GO:0003351)8.78031180
7motile cilium assembly (GO:0044458)8.73972809
8spermatid development (GO:0007286)8.67714564
9cilium or flagellum-dependent cell motility (GO:0001539)8.20592594
10reproduction (GO:0000003)8.04270140
11regulation of cilium movement (GO:0003352)7.95606560
12cilium movement (GO:0003341)7.29059450
13sperm capacitation (GO:0048240)7.00841474
14response to pheromone (GO:0019236)6.77822039
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.72903873
16negative regulation of inclusion body assembly (GO:0090084)6.71278015
17single fertilization (GO:0007338)6.64905425
18synaptonemal complex organization (GO:0070193)6.38851670
19male meiosis (GO:0007140)6.22128219
20piRNA metabolic process (GO:0034587)6.15414355
21synaptonemal complex assembly (GO:0007130)6.14966593
22spermatogenesis (GO:0007283)6.10269667
23male gamete generation (GO:0048232)6.07547812
24microtubule depolymerization (GO:0007019)5.91211647
25calcium ion-dependent exocytosis (GO:0017156)5.81650206
26organic cation transport (GO:0015695)5.75710003
27fertilization (GO:0009566)5.59601324
28gamete generation (GO:0007276)5.59012703
29regulation of inclusion body assembly (GO:0090083)5.40570063
30phosphatidylethanolamine biosynthetic process (GO:0006646)5.16234130
31cell recognition (GO:0008037)4.99938031
32cellular process involved in reproduction in multicellular organism (GO:0022412)4.89156078
33regulation of microtubule-based movement (GO:0060632)4.89011478
34protein targeting to Golgi (GO:0000042)4.88307250
35germ cell development (GO:0007281)4.82060445
36rRNA methylation (GO:0031167)4.78081025
37establishment of protein localization to Golgi (GO:0072600)4.73561875
38regulation of Rab GTPase activity (GO:0032313)4.73324680
39positive regulation of Rab GTPase activity (GO:0032851)4.73324680
40ventricular system development (GO:0021591)4.68396406
41phosphatidylethanolamine metabolic process (GO:0046337)4.66114620
42retrograde transport, vesicle recycling within Golgi (GO:0000301)4.59811647
43microtubule severing (GO:0051013)4.53787857
44chromatin silencing (GO:0006342)4.44908302
45multicellular organismal reproductive process (GO:0048609)4.37199471
46male meiosis I (GO:0007141)4.28676241
47chromosome condensation (GO:0030261)4.22105002
48seminiferous tubule development (GO:0072520)4.21709626
49spermatid nucleus differentiation (GO:0007289)4.20334408
50left/right pattern formation (GO:0060972)4.19490497
51DNA packaging (GO:0006323)4.11999207
52regulation of ARF GTPase activity (GO:0032312)4.10950231
53regulation of transcription involved in cell fate commitment (GO:0060850)4.07440058
54chromosome organization involved in meiosis (GO:0070192)3.96660043
55DNA methylation involved in gamete generation (GO:0043046)3.91517490
56protein localization to cilium (GO:0061512)3.89595983
57single strand break repair (GO:0000012)3.80711482
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76024084
59glycerol ether metabolic process (GO:0006662)3.74479839
60rRNA modification (GO:0000154)3.72535896
61cranial nerve morphogenesis (GO:0021602)3.72162264
62protein polyglutamylation (GO:0018095)3.61862608
63ether metabolic process (GO:0018904)3.58574278
64synaptic vesicle docking involved in exocytosis (GO:0016081)3.57884540
65sodium ion export (GO:0071436)3.56869318
66coenzyme catabolic process (GO:0009109)3.56627896
67meiotic nuclear division (GO:0007126)3.56371078
68protein localization to Golgi apparatus (GO:0034067)3.56317316
69cytoskeletal anchoring at plasma membrane (GO:0007016)3.54688938
70cerebral cortex neuron differentiation (GO:0021895)3.51467138
71cellular ketone body metabolic process (GO:0046950)3.49871656
72locomotory exploration behavior (GO:0035641)3.49771291
73multicellular organismal development (GO:0007275)3.49372208
74centriole assembly (GO:0098534)3.49065833
75synaptic vesicle exocytosis (GO:0016079)3.48982560
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47066749
77glutamate secretion (GO:0014047)3.40849667
78negative regulation of Rho protein signal transduction (GO:0035024)3.37484870
79neuronal ion channel clustering (GO:0045161)3.36814076
80cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.35523929
81protein K11-linked deubiquitination (GO:0035871)3.33800746
82regulation of interleukin-13 production (GO:0032656)3.33766401
83membrane depolarization during action potential (GO:0086010)3.31722409
84regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29290538
85meiosis I (GO:0007127)3.27391415
86glycolytic process (GO:0006096)3.27355229
87sexual reproduction (GO:0019953)3.26782979
88centriole replication (GO:0007099)3.26736973
89histone H3-K9 demethylation (GO:0033169)3.25781614
90chaperone-mediated protein complex assembly (GO:0051131)3.25293322
91calcium ion import (GO:0070509)3.23198864
92regulation of synaptic vesicle exocytosis (GO:2000300)3.21833200
93regulation of phosphoprotein phosphatase activity (GO:0043666)3.21108043
94regulation of spindle checkpoint (GO:0090231)3.11285683
95cell-cell junction maintenance (GO:0045217)3.10993461
96negative regulation of gene expression, epigenetic (GO:0045814)3.09308457
97microtubule polymerization or depolymerization (GO:0031109)3.08934218
98regulation of T-helper 2 cell differentiation (GO:0045628)3.06408076
99protein depolymerization (GO:0051261)3.06113497
100actin filament capping (GO:0051693)3.06087817
101ketone body metabolic process (GO:1902224)3.01868099
102dendritic spine organization (GO:0097061)3.01481541
103cellular response to pH (GO:0071467)3.00620885
104RNA localization (GO:0006403)2.99547643
105monoubiquitinated protein deubiquitination (GO:0035520)2.98674649
106sequestering of actin monomers (GO:0042989)2.98572441
107multicellular organismal movement (GO:0050879)2.97836335
108musculoskeletal movement (GO:0050881)2.97836335
109microtubule-based movement (GO:0007018)2.96463884
110negative regulation of organelle assembly (GO:1902116)2.96382748
111cilium organization (GO:0044782)2.95985221
112regulation of somitogenesis (GO:0014807)2.95007051
113lactate metabolic process (GO:0006089)2.93701789
114mitotic G1 DNA damage checkpoint (GO:0031571)2.92084344
115intraciliary transport (GO:0042073)2.90902059
116positive regulation of synapse maturation (GO:0090129)2.89460473
117protein refolding (GO:0042026)2.86946765
118face development (GO:0060324)2.86715799
119receptor recycling (GO:0001881)2.84862510
120synaptic vesicle maturation (GO:0016188)2.84668371
121cilium assembly (GO:0042384)2.84434443
122regulation of synaptic vesicle transport (GO:1902803)2.83585852
123axoneme assembly (GO:0035082)2.81391979
124detection of light stimulus involved in sensory perception (GO:0050962)2.78380507
125detection of light stimulus involved in visual perception (GO:0050908)2.78380507
126vesicle transport along microtubule (GO:0047496)2.77927624
127RNA destabilization (GO:0050779)2.77649657
128nucleosome disassembly (GO:0006337)2.76656592
129protein-DNA complex disassembly (GO:0032986)2.76656592
130cellular component assembly involved in morphogenesis (GO:0010927)2.75482343
131amino-acid betaine transport (GO:0015838)2.72827975
132carnitine transport (GO:0015879)2.72827975
133regulation of cilium assembly (GO:1902017)2.72589544
134meiotic cell cycle (GO:0051321)2.72224826
135insulin-like growth factor receptor signaling pathway (GO:0048009)2.71264254
136urinary tract smooth muscle contraction (GO:0014848)2.70599225
137genitalia morphogenesis (GO:0035112)2.70163929
138response to acidic pH (GO:0010447)2.67619414
139cilium morphogenesis (GO:0060271)2.67474779
140nucleus organization (GO:0006997)2.67360981
141mitotic sister chromatid cohesion (GO:0007064)2.62090410
142carnitine transmembrane transport (GO:1902603)2.59659709
143regulation of acrosome reaction (GO:0060046)2.57560886
144positive regulation of macrophage activation (GO:0043032)2.54190349
145polyol catabolic process (GO:0046174)2.47268808
146interferon-gamma secretion (GO:0072643)2.46097615
147peptidyl-glutamic acid modification (GO:0018200)2.42756735
148nucleoside diphosphate phosphorylation (GO:0006165)2.40515603
149sperm motility (GO:0030317)12.6583142
150fusion of sperm to egg plasma membrane (GO:0007342)11.6122084
151cell wall macromolecule catabolic process (GO:0016998)11.5948555
152cell wall macromolecule metabolic process (GO:0044036)11.5948555
153acrosome reaction (GO:0007340)11.5652589
154acrosome assembly (GO:0001675)10.3529942
155sperm-egg recognition (GO:0035036)10.3300489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.97859098
2EZH2_22144423_ChIP-Seq_EOC_Human5.29172568
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.27978836
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.06274411
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.99948403
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21332468
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99399389
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.49736825
9LXR_22292898_ChIP-Seq_THP-1_Human2.49051301
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42492527
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37745536
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37323584
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31800267
14* CTCF_27219007_Chip-Seq_Bcells_Human2.24058565
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.22058329
16SMC4_20622854_ChIP-Seq_HELA_Human2.18106101
17ZNF274_21170338_ChIP-Seq_K562_Hela2.17265004
18* REST_21632747_ChIP-Seq_MESCs_Mouse2.09311468
19P68_20966046_ChIP-Seq_HELA_Human2.03860412
20VDR_22108803_ChIP-Seq_LS180_Human2.02213637
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94976992
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.94606568
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.92219109
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73181769
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69845502
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68499101
27* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66212232
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63848553
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63534110
30TP63_22573176_ChIP-Seq_HFKS_Human1.62584504
31ERA_21632823_ChIP-Seq_H3396_Human1.62534193
32BCL6_27268052_Chip-Seq_Bcells_Human1.60539887
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60502574
34KDM2B_26808549_Chip-Seq_K562_Human1.60492525
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.59411163
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58903361
37CBP_20019798_ChIP-Seq_JUKART_Human1.55346460
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55346460
39BCOR_27268052_Chip-Seq_Bcells_Human1.55097406
40PHF8_20622854_ChIP-Seq_HELA_Human1.54786887
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.52488641
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.52411607
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51183678
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.50786725
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50624998
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.49174847
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49116368
48* CTCF_20526341_ChIP-Seq_ESCs_Human1.47623724
49E2F1_20622854_ChIP-Seq_HELA_Human1.46858401
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45651815
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.44799721
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.44514948
53KDM2B_26808549_Chip-Seq_REH_Human1.43979309
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43891803
55RAC3_21632823_ChIP-Seq_H3396_Human1.43423378
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.42474965
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40522552
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40522552
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40421386
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.38440946
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.38102376
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37669119
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.35916546
64FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34756490
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.34739071
66OCT4_19829295_ChIP-Seq_ESCs_Human1.34213087
67AR_21572438_ChIP-Seq_LNCaP_Human1.34191348
68KDM2B_26808549_Chip-Seq_DND41_Human1.33862947
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.33801146
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.32328345
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32135431
72DROSHA_22980978_ChIP-Seq_HELA_Human1.32042252
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31905579
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30924856
75STAT1_17558387_ChIP-Seq_HELA_Human1.30885074
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30195502
77TAF15_26573619_Chip-Seq_HEK293_Human1.27801641
78NANOG_20526341_ChIP-Seq_ESCs_Human1.26231624
79* SA1_27219007_Chip-Seq_Bcells_Human1.25690189
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.24512322
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24194135
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24190606
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24180401
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24180401
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23051650
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.23001362
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22957470
88OCT4_20526341_ChIP-Seq_ESCs_Human1.22826912
89* EZH2_27294783_Chip-Seq_ESCs_Mouse1.22220953
90* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21481232
91SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21137727
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.19290356
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18781775
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18667857
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18430785
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18138869
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17876859
98GATA3_21867929_ChIP-Seq_CD8_Mouse1.17674173
99* REST_18959480_ChIP-ChIP_MESCs_Mouse1.17035677
100GBX2_23144817_ChIP-Seq_PC3_Human1.16752917
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15992622
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14440486
103GF1_26923725_Chip-Seq_HPCs_Mouse1.14126919
104RNF2_27304074_Chip-Seq_NSC_Mouse1.12860291
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12463434
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.11720467
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11650116
108* TET1_21451524_ChIP-Seq_MESCs_Mouse1.11558549
109KLF4_19829295_ChIP-Seq_ESCs_Human1.11451960
110LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11386804
111MYC_19829295_ChIP-Seq_ESCs_Human1.10437173
112FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10270001
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.09393954
114P300_27268052_Chip-Seq_Bcells_Human1.09109085
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08885605
116TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07705923
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07688892
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.07621922
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07341606
120SOX9_26525672_Chip-Seq_HEART_Mouse1.06424002
121SMAD4_21799915_ChIP-Seq_A2780_Human1.05575445
122TAF2_19829295_ChIP-Seq_ESCs_Human1.05265545
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05203688
124RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04757770
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04546406
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04318956
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03949966
128RARB_27405468_Chip-Seq_BRAIN_Mouse1.03181103
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01490262
130RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01099009
131SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01067672
132SMAD4_21741376_ChIP-Seq_ESCs_Human1.00844526
133* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00313611
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00084152
135BP1_19119308_ChIP-ChIP_Hs578T_Human1.00039296
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00006549
137CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00000598
138P53_21459846_ChIP-Seq_SAOS-2_Human0.99718537
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99408705
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99214584
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.98076632
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97953464
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.97820409
144TCF7_22412390_ChIP-Seq_EML_Mouse0.96687283
145GATA3_21867929_ChIP-Seq_TH1_Mouse0.96334909
146JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96091712
147FUS_26573619_Chip-Seq_HEK293_Human0.95886557
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.95514435
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95252657
150CREB1_26743006_Chip-Seq_LNCaP_Human0.95123283
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94959660
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94952848
153KLF5_25053715_ChIP-Seq_YYC3_Human0.94783119
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93967895
155TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93029578
156TCF4_23295773_ChIP-Seq_U87_Human0.92460269
157TBL1_22424771_ChIP-Seq_293T_Human0.92104308
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.91879096
159P53_22387025_ChIP-Seq_ESCs_Mouse0.91161791
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90799314
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90466695
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.90297808
163RNF2_27304074_Chip-Seq_ESCs_Mouse0.90105969
164SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.89936541
165ER_23166858_ChIP-Seq_MCF-7_Human0.88902565
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88782484
167PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88157795
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87756417
169EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86850124
170SMAD4_21741376_ChIP-Seq_EPCs_Human0.86129750
171GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85761757
172CRX_20693478_ChIP-Seq_RETINA_Mouse0.85537259
173OCT4_18555785_Chip-Seq_ESCs_Mouse0.85355305
174P300_18555785_Chip-Seq_ESCs_Mouse0.84534739
175CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84049183
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83534909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.21785946
2MP0001929_abnormal_gametogenesis4.57256979
3MP0003878_abnormal_ear_physiology4.01609112
4MP0005377_hearing/vestibular/ear_phenot4.01609112
5MP0008877_abnormal_DNA_methylation3.31444588
6MP0000678_abnormal_parathyroid_gland2.98557576
7MP0002161_abnormal_fertility/fecundity2.78518951
8MP0002210_abnormal_sex_determination2.66334717
9MP0002249_abnormal_larynx_morphology2.61566955
10MP0005670_abnormal_white_adipose2.54745363
11MP0001145_abnormal_male_reproductive2.30985201
12MP0005551_abnormal_eye_electrophysiolog2.19917084
13MP0001984_abnormal_olfaction2.16669657
14MP0004859_abnormal_synaptic_plasticity2.16657643
15MP0002132_abnormal_respiratory_system2.14750781
16MP0003880_abnormal_central_pattern2.10441665
17MP0009046_muscle_twitch2.07401542
18MP0004233_abnormal_muscle_weight2.00102471
19MP0005410_abnormal_fertilization13.9738706
20MP0000653_abnormal_sex_gland1.98807874
21MP0005423_abnormal_somatic_nervous1.75320335
22MP0002653_abnormal_ependyma_morphology1.73404160
23MP0003635_abnormal_synaptic_transmissio1.64173465
24MP0005623_abnormal_meninges_morphology1.52767323
25MP0005248_abnormal_Harderian_gland1.52554858
26MP0004510_myositis1.51992505
27MP0000681_abnormal_thyroid_gland1.51125185
28MP0004270_analgesia1.41859603
29MP0001486_abnormal_startle_reflex1.39105316
30MP0009745_abnormal_behavioral_response1.38675482
31MP0002822_catalepsy1.36759155
32MP0001968_abnormal_touch/_nociception1.36027545
33MP0002736_abnormal_nociception_after1.35802435
34MP0002063_abnormal_learning/memory/cond1.34785086
35MP0002160_abnormal_reproductive_system1.34695442
36MP0003646_muscle_fatigue1.30938835
37MP0005253_abnormal_eye_physiology1.29649327
38MP0002064_seizures1.27807718
39MP0002572_abnormal_emotion/affect_behav1.25898842
40MP0003011_delayed_dark_adaptation1.25342715
41MP0002272_abnormal_nervous_system1.24167957
42MP0001849_ear_inflammation1.22083577
43MP0006072_abnormal_retinal_apoptosis1.21915663
44MP0001485_abnormal_pinna_reflex1.14455581
45MP0005409_darkened_coat_color1.13014094
46MP0002127_abnormal_cardiovascular_syste1.11219281
47MP0001501_abnormal_sleep_pattern1.10960703
48MP0003787_abnormal_imprinting1.08897273
49MP0001963_abnormal_hearing_physiology1.08445924
50MP0002734_abnormal_mechanical_nocicepti1.04688596
51MP0001529_abnormal_vocalization1.02458521
52MP0004811_abnormal_neuron_physiology1.01216335
53MP0003950_abnormal_plasma_membrane1.00942439
54MP0003718_maternal_effect1.00522561
55MP0008569_lethality_at_weaning0.98301781
56MP0001765_abnormal_ion_homeostasis0.97402754
57MP0002735_abnormal_chemical_nociception0.95394261
58MP0002234_abnormal_pharynx_morphology0.94722521
59MP0005310_abnormal_salivary_gland0.92776979
60MP0001502_abnormal_circadian_rhythm0.91379650
61MP0000566_synostosis0.90780041
62MP0003705_abnormal_hypodermis_morpholog0.90235673
63MP0000026_abnormal_inner_ear0.90067114
64MP0005195_abnormal_posterior_eye0.89668542
65MP0001348_abnormal_lacrimal_gland0.88478381
66MP0005499_abnormal_olfactory_system0.87783566
67MP0005394_taste/olfaction_phenotype0.87783566
68MP0001324_abnormal_eye_pigmentation0.85749559
69MP0004036_abnormal_muscle_relaxation0.85258861
70MP0002928_abnormal_bile_duct0.83774714
71MP0002229_neurodegeneration0.82234310
72MP0001440_abnormal_grooming_behavior0.79811146
73MP0002067_abnormal_sensory_capabilities0.79640685
74MP0003329_amyloid_beta_deposits0.78842409
75MP0003633_abnormal_nervous_system0.78346466
76MP0002882_abnormal_neuron_morphology0.77676847
77MP0001188_hyperpigmentation0.77342391
78MP0000049_abnormal_middle_ear0.76193676
79MP0001270_distended_abdomen0.75761295
80MP0005647_abnormal_sex_gland0.75529880
81MP0009780_abnormal_chondrocyte_physiolo0.74578036
82MP0002557_abnormal_social/conspecific_i0.73615038
83MP0003632_abnormal_nervous_system0.72424495
84MP0000569_abnormal_digit_pigmentation0.72312543
85MP0001299_abnormal_eye_distance/0.72062425
86MP0002909_abnormal_adrenal_gland0.71510550
87MP0001905_abnormal_dopamine_level0.70522447
88MP0002152_abnormal_brain_morphology0.69937920
89MP0000003_abnormal_adipose_tissue0.69146902
90MP0004085_abnormal_heartbeat0.68217931
91MP0002090_abnormal_vision0.67650010
92MP0003631_nervous_system_phenotype0.66876648
93MP0001970_abnormal_pain_threshold0.66304491
94MP0004742_abnormal_vestibular_system0.66023129
95MP0009053_abnormal_anal_canal0.65114188
96MP0003091_abnormal_cell_migration0.63827612
97MP0000955_abnormal_spinal_cord0.63627890
98MP0003634_abnormal_glial_cell0.63142420
99MP0002752_abnormal_somatic_nervous0.63018750
100MP0005167_abnormal_blood-brain_barrier0.62754764
101MP0003879_abnormal_hair_cell0.62499074
102MP0002066_abnormal_motor_capabilities/c0.61898833
103MP0005391_vision/eye_phenotype0.61336603
104MP0002184_abnormal_innervation0.60541134
105MP0003119_abnormal_digestive_system0.60503132
106MP0000778_abnormal_nervous_system0.59867912
107MP0003385_abnormal_body_wall0.58332001
108MP0005083_abnormal_biliary_tract0.58065504
109MP0005389_reproductive_system_phenotype0.57505197
110MP0000920_abnormal_myelination0.56913753
111MP0003115_abnormal_respiratory_system0.56475427
112MP0008995_early_reproductive_senescence0.56358683
113MP0000579_abnormal_nail_morphology0.55546368
114MP0000534_abnormal_ureter_morphology0.55482682
115MP0002138_abnormal_hepatobiliary_system0.54719883
116MP0000751_myopathy0.54467240
117MP0008874_decreased_physiological_sensi0.53157081
118MP0004924_abnormal_behavior0.52938672
119MP0005386_behavior/neurological_phenoty0.52938672
120MP0002733_abnormal_thermal_nociception0.52834547
121MP0002282_abnormal_trachea_morphology0.52286691
122MP0005646_abnormal_pituitary_gland0.51918378
123MP0003942_abnormal_urinary_system0.50382831
124MP0008961_abnormal_basal_metabolism0.49991451
125MP0006292_abnormal_olfactory_placode0.49857788
126MP0001346_abnormal_lacrimal_gland0.48373475
127MP0003172_abnormal_lysosome_physiology0.48297824
128MP0000163_abnormal_cartilage_morphology0.47150927
129MP0003861_abnormal_nervous_system0.46492018
130MP0003183_abnormal_peptide_metabolism0.46450073
131MP0006276_abnormal_autonomic_nervous0.45917527
132MP0000631_abnormal_neuroendocrine_gland0.45212914
133MP0006035_abnormal_mitochondrial_morpho0.44128529
134MP0004133_heterotaxia0.43818317
135MP0004145_abnormal_muscle_electrophysio0.43506201
136MP0010386_abnormal_urinary_bladder0.40930894
137MP0008872_abnormal_physiological_respon0.40859303
138MP0000358_abnormal_cell_content/0.40065363
139MP0002269_muscular_atrophy0.39040878
140MP0006036_abnormal_mitochondrial_physio0.37504696
141MP0004084_abnormal_cardiac_muscle0.36668397
142MP0001986_abnormal_taste_sensitivity0.36262845
143MP0005666_abnormal_adipose_tissue0.36116967

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.37186869
2Abnormal respiratory motile cilium morphology (HP:0005938)8.19723937
3Abnormal respiratory epithelium morphology (HP:0012253)8.19723937
4Rhinitis (HP:0012384)6.75936339
5Abnormal ciliary motility (HP:0012262)6.61431670
6Chronic bronchitis (HP:0004469)6.31223624
7Infertility (HP:0000789)6.15161308
8Nasal polyposis (HP:0100582)5.17615943
9Resting tremor (HP:0002322)4.73793559
10Nephronophthisis (HP:0000090)4.40266203
11Asymmetric septal hypertrophy (HP:0001670)4.19971341
12Abnormality of the nasal mucosa (HP:0000433)4.09664543
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.06735799
14Hypoplastic ischia (HP:0003175)4.04061508
15Male infertility (HP:0003251)3.88960308
16Bronchiectasis (HP:0002110)3.80040197
17Bronchitis (HP:0012387)3.77848613
18Enlarged epiphyses (HP:0010580)3.76521531
19Abnormality of the ischium (HP:0003174)3.71003413
20Abnormality of the aortic arch (HP:0012303)3.33085059
21Abnormality of the renal medulla (HP:0100957)3.24615150
22Dyschromatopsia (HP:0007641)3.15780639
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.14697281
24Medial flaring of the eyebrow (HP:0010747)3.03029816
25Recurrent otitis media (HP:0000403)3.00646571
26Abnormal gallbladder physiology (HP:0012438)2.99715081
27Cholecystitis (HP:0001082)2.99715081
28Recurrent sinusitis (HP:0011108)2.91241495
29Aplasia/Hypoplasia of the earlobes (HP:0009906)2.89712108
30Decreased central vision (HP:0007663)2.86725540
31Abnormality of midbrain morphology (HP:0002418)2.84452338
32Molar tooth sign on MRI (HP:0002419)2.84452338
33Atonic seizures (HP:0010819)2.80149823
34Abnormal spermatogenesis (HP:0008669)2.79483223
35Chronic hepatic failure (HP:0100626)2.62845760
36Epiphyseal dysplasia (HP:0002656)2.54352790
37Tubulointerstitial nephritis (HP:0001970)2.51894205
38Facial shape deformation (HP:0011334)2.48814441
39Potter facies (HP:0002009)2.48814441
40Bowel incontinence (HP:0002607)2.47968311
41Abnormal rod and cone electroretinograms (HP:0008323)2.44373303
42Genetic anticipation (HP:0003743)2.40620775
43Hypoplasia of the thymus (HP:0000778)2.40479005
44Choroideremia (HP:0001139)2.40197417
45Renovascular hypertension (HP:0100817)2.38910533
46Obstructive sleep apnea (HP:0002870)2.36232540
47Urethral obstruction (HP:0000796)2.35903416
48Tubular atrophy (HP:0000092)2.33216406
49Congenital stationary night blindness (HP:0007642)2.31358586
50Tubulointerstitial abnormality (HP:0001969)2.30791684
51Hyperthyroidism (HP:0000836)2.30758976
52Peripheral hypomyelination (HP:0007182)2.29129705
53Focal motor seizures (HP:0011153)2.26763007
54Amblyopia (HP:0000646)2.25877543
55Mixed hearing impairment (HP:0000410)2.24585542
56Flattened epiphyses (HP:0003071)2.22629874
57Stereotypic behavior (HP:0000733)2.22135783
58Truncal obesity (HP:0001956)2.17563311
59Gonadotropin excess (HP:0000837)2.16190851
60Abnormal large intestine physiology (HP:0012700)2.15723175
61Atelectasis (HP:0100750)2.13320641
62Progressive cerebellar ataxia (HP:0002073)2.12741046
63Recurrent bronchitis (HP:0002837)2.08931939
64Impulsivity (HP:0100710)2.08131029
65Neurofibrillary tangles (HP:0002185)2.06576807
66Abnormality of the lower motor neuron (HP:0002366)2.05336592
67Congenital malformation of the right heart (HP:0011723)2.02884747
68Double outlet right ventricle (HP:0001719)2.02884747
69Hemiparesis (HP:0001269)2.01736043
70Hypoalphalipoproteinemia (HP:0003233)2.00957652
71Dynein arm defect of respiratory motile cilia (HP:0012255)12.2223066
72Absent/shortened dynein arms (HP:0200106)12.2223066
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6879378
74Cerebral hypomyelination (HP:0006808)1.99856393
75Dysmetria (HP:0001310)1.98766554
76Focal seizures (HP:0007359)1.98600381
77Central scotoma (HP:0000603)1.96338206
78Unilateral renal agenesis (HP:0000122)1.95870718
79Annular pancreas (HP:0001734)1.94598060
80Febrile seizures (HP:0002373)1.93914765
81Tubulointerstitial fibrosis (HP:0005576)1.93707339
82Broad face (HP:0000283)1.92155892
83Hypoparathyroidism (HP:0000829)1.91481350
84Abnormality of the pubic bones (HP:0003172)1.91007314
85Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90602973
86Spastic tetraparesis (HP:0001285)1.89948107
87Action tremor (HP:0002345)1.89905753
88Progressive sensorineural hearing impairment (HP:0000408)1.88188992
89Atrophic scars (HP:0001075)1.86352857
90Gait imbalance (HP:0002141)1.85739285
91Bradykinesia (HP:0002067)1.85722897
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85530465
93Cone-rod dystrophy (HP:0000548)1.84823371
94Cerebral inclusion bodies (HP:0100314)1.82006915
95Epileptic encephalopathy (HP:0200134)1.81874446
96Delusions (HP:0000746)1.81569781
97Sensory axonal neuropathy (HP:0003390)1.80731561
98Bony spicule pigmentary retinopathy (HP:0007737)1.79864972
99Supranuclear gaze palsy (HP:0000605)1.79780187
100Bradycardia (HP:0001662)1.79643282
101Postaxial foot polydactyly (HP:0001830)1.77953894
102Abnormality of the epiphysis of the femoral head (HP:0010574)1.77485465
103Congenital primary aphakia (HP:0007707)1.77256051
104Vertebral clefting (HP:0008428)1.76649724
105Congenital hepatic fibrosis (HP:0002612)1.74326016
106Abnormality of the parathyroid morphology (HP:0011766)1.73999159
107Heterotopia (HP:0002282)1.73470959
108Abnormality of macular pigmentation (HP:0008002)1.72889499
109Amelogenesis imperfecta (HP:0000705)1.72173757
110Abnormality of femoral epiphyses (HP:0006499)1.72161549
111Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72161549
112Papilledema (HP:0001085)1.71834503
113Colitis (HP:0002583)1.71416585
114Aplasia/Hypoplasia of the lens (HP:0008063)1.70828309
115Ventricular tachycardia (HP:0004756)1.69867048
116Attenuation of retinal blood vessels (HP:0007843)1.69641332
117Underdeveloped nasal alae (HP:0000430)1.69605017
118Truncus arteriosus (HP:0001660)1.69094394
119Hand muscle atrophy (HP:0009130)1.68110674
120Abnormal drinking behavior (HP:0030082)1.68046797
121Polydipsia (HP:0001959)1.68046797
122Azoospermia (HP:0000027)1.67403382
123Stage 5 chronic kidney disease (HP:0003774)1.66606698
124Neoplasm of striated muscle (HP:0009728)1.66513259
125Oculomotor apraxia (HP:0000657)1.65969546
126Impaired vibration sensation in the lower limbs (HP:0002166)1.63571353
127Exercise-induced myalgia (HP:0003738)1.63251316
128Visual hallucinations (HP:0002367)1.62651976
129Distal upper limb amyotrophy (HP:0007149)1.62396535
130Upper limb amyotrophy (HP:0009129)1.62396535
131Abnormality of dental color (HP:0011073)1.62171051
132Postaxial hand polydactyly (HP:0001162)1.61022414
133Ankle clonus (HP:0011448)1.59635125
134Bile duct proliferation (HP:0001408)1.57941984
135Abnormal biliary tract physiology (HP:0012439)1.57941984
136Abnormality of ocular smooth pursuit (HP:0000617)1.56088411
137Myokymia (HP:0002411)1.55511128
138Nephrogenic diabetes insipidus (HP:0009806)1.53878842
139Constricted visual fields (HP:0001133)1.52668507
140Retinal dysplasia (HP:0007973)1.49138729
141Absent epiphyses (HP:0010577)1.46799691
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.46799691
143Vaginal atresia (HP:0000148)1.46791792
144Genital tract atresia (HP:0001827)1.46687920
145Amyotrophic lateral sclerosis (HP:0007354)1.46484317
146Renal dysplasia (HP:0000110)1.45919608
147Gaze-evoked nystagmus (HP:0000640)1.45602493
148Postural instability (HP:0002172)1.44959408
149Spastic gait (HP:0002064)1.44797964
150Abnormality of saccadic eye movements (HP:0000570)1.44167844
151Hyperkalemia (HP:0002153)1.42240917
152Fibular hypoplasia (HP:0003038)1.42114917
153Bell-shaped thorax (HP:0001591)1.41716508
154Neoplasm of the heart (HP:0100544)1.41479581
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41379632
156Poor coordination (HP:0002370)1.40464802
157Short ribs (HP:0000773)1.38604557
158Severe visual impairment (HP:0001141)1.38040221
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.37633273
160Pachygyria (HP:0001302)1.37514639
161Type II diabetes mellitus (HP:0005978)1.37358250
162J-shaped sella turcica (HP:0002680)1.35881152
163Deformed sella turcica (HP:0002681)1.35280569
164Bundle branch block (HP:0011710)1.34694010
165Pancreatic fibrosis (HP:0100732)1.34512396
166Abnormality of renal excretion (HP:0011036)1.33794589
167Lower limb muscle weakness (HP:0007340)1.31829755
168Taurodontia (HP:0000679)1.31363796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.64331607
2PDK46.64331607
3PRKD36.38695202
4TESK16.30699768
5PLK45.23995679
6ICK4.48258314
7DDR24.26253693
8PDK24.07568766
9PTK2B2.53741448
10PNCK2.49342094
11INSRR2.23573548
12STK382.21675170
13CDK122.19015425
14BRD42.14823653
15MST1R2.00956137
16STK391.93689878
17WNK41.76667520
18LATS21.61880366
19NEK21.60089000
20TRIB31.48947596
21UHMK11.43369216
22STK38L1.38390735
23DYRK1B1.38190689
24NLK1.36346061
25CDK31.24833529
26CAMK1G1.24211308
27TESK21.22698221
28PDK11.19520718
29TYRO31.18549633
30MAP4K21.09089956
31NTRK31.06117834
32RIPK40.98621497
33AKT30.98439092
34PINK10.93597420
35ARAF0.93184596
36RPS6KA20.91197094
37MAP3K40.89775704
38NTRK20.87842205
39PAK60.87669708
40EPHA40.85185256
41MARK10.84056775
42PDPK10.82931403
43LMTK20.82011079
44CAMK40.81299713
45WNK10.77671943
46PRKG20.76455976
47CDK70.75757721
48LATS10.75048986
49MAP3K130.73054458
50PRKCG0.73002684
51TNK20.68013268
52BRAF0.66988723
53MAP2K70.66211930
54MAP3K110.65310147
55CAMKK10.65271150
56MINK10.64550469
57PKN10.63283584
58CDK190.60737533
59MARK20.59862444
60ROCK10.56334810
61CDK40.55074339
62RPS6KA10.54814181
63SGK10.54693890
64SIK10.54065879
65CHEK20.53031193
66PRKCZ0.52247146
67MAP2K60.51691264
68IRAK10.49032445
69CDK150.48981586
70MAP3K20.48817288
71RPS6KL10.48204059
72RPS6KC10.48204059
73CDK50.47209364
74MET0.46626415
75MAPK130.46310781
76PRPF4B0.46293645
77CDK180.46042408
78MAPK10.44366862
79EEF2K0.43480912
80NTRK10.43343422
81CDC42BPA0.42240885
82PRKAA10.41768718
83MAP3K70.41651504
84RPS6KA60.41383682
85SGK2230.41354975
86SGK4940.41354975
87CDK140.40983072
88FGFR20.40809794
89MARK30.40782059
90NEK60.40363113
91FES0.40080030
92MAPK70.39503085
93PHKG10.38982793
94PHKG20.38982793
95CDK11A0.38876944
96MAP2K20.38793157
97CLK10.38745874
98CDK20.37315635
99MAPK150.36781887
100MAP3K100.36661082
101DYRK30.36531981
102GRK50.36211645
103DYRK1A0.35790756
104CAMK2A0.35625896
105PRKAA20.34985671
106MAP3K80.34493146
107RET0.34398225
108PAK10.33444970
109CHEK10.32962462
110IRAK20.32663902
111CDK10.31905490
112MAP2K40.30268958
113STK110.29863067
114CCNB10.27802107
115SGK20.25403264
116CAMK10.23104637
117SIK20.23087939
118PRKD20.22393768
119PRKCB0.21890363
120GSK3B0.21516250
121MTOR0.20608554
122PAK30.20484111
123MAP3K90.20060889
124ATM0.20011165
125STK30.19522242
126RIPK10.19307508
127RPS6KB10.19204829
128RPS6KA30.18445708
129MAPK100.17934738
130PRKCH0.17654234
131PRKCA0.17510456
132YES10.17469790
133MAPK80.17063060
134MAPKAPK50.16573271
135MAP3K10.16368196
136CAMK1D0.15661577
137PRKCQ0.15200577
138PRKG10.14700223
139KSR20.14482883
140TNIK0.14191089
141CASK0.14027312
142ATR0.13780595
143DAPK20.12506361
144MUSK0.12134091
145PLK20.12066713
146WNK30.11875653
147SGK30.11843555
148PRKACA0.11287847
149GRK10.10567054

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.62465375
2Fatty acid biosynthesis_Homo sapiens_hsa000613.32468870
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.17662357
4Synaptic vesicle cycle_Homo sapiens_hsa047212.58832653
5Vitamin B6 metabolism_Homo sapiens_hsa007502.54473877
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43108729
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36462024
8Nicotine addiction_Homo sapiens_hsa050332.32436518
9Amphetamine addiction_Homo sapiens_hsa050312.31932937
10Glucagon signaling pathway_Homo sapiens_hsa049222.29886261
11Pyruvate metabolism_Homo sapiens_hsa006202.27553337
12Phototransduction_Homo sapiens_hsa047442.19845112
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14376302
14Renin secretion_Homo sapiens_hsa049241.89746435
15Circadian entrainment_Homo sapiens_hsa047131.86873902
16Cardiac muscle contraction_Homo sapiens_hsa042601.80363534
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77032141
18Linoleic acid metabolism_Homo sapiens_hsa005911.76344494
19Long-term potentiation_Homo sapiens_hsa047201.76039033
20Olfactory transduction_Homo sapiens_hsa047401.71293675
21Insulin secretion_Homo sapiens_hsa049111.70593944
22Salivary secretion_Homo sapiens_hsa049701.65092378
23Collecting duct acid secretion_Homo sapiens_hsa049661.63740254
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62909508
25Glutamatergic synapse_Homo sapiens_hsa047241.62863622
26Morphine addiction_Homo sapiens_hsa050321.54795998
27Oocyte meiosis_Homo sapiens_hsa041141.54418186
28Propanoate metabolism_Homo sapiens_hsa006401.47986938
29Dorso-ventral axis formation_Homo sapiens_hsa043201.45027545
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44837819
31GABAergic synapse_Homo sapiens_hsa047271.40490791
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.35483090
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31225869
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30816525
35Dopaminergic synapse_Homo sapiens_hsa047281.28693178
36Calcium signaling pathway_Homo sapiens_hsa040201.27885348
37Fructose and mannose metabolism_Homo sapiens_hsa000511.27330378
38Glycerolipid metabolism_Homo sapiens_hsa005611.25643601
39Alcoholism_Homo sapiens_hsa050341.23152139
40Cocaine addiction_Homo sapiens_hsa050301.22753391
41Taste transduction_Homo sapiens_hsa047421.22442301
42Mineral absorption_Homo sapiens_hsa049781.18915931
43Gastric acid secretion_Homo sapiens_hsa049711.17380470
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16795584
45Pentose phosphate pathway_Homo sapiens_hsa000301.15631408
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15058335
47Melanogenesis_Homo sapiens_hsa049161.12678987
48Oxytocin signaling pathway_Homo sapiens_hsa049211.03809599
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02918145
50Systemic lupus erythematosus_Homo sapiens_hsa053221.00041712
51Ether lipid metabolism_Homo sapiens_hsa005650.99809595
52Estrogen signaling pathway_Homo sapiens_hsa049150.98238250
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97909931
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95063384
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93820280
56Choline metabolism in cancer_Homo sapiens_hsa052310.91833637
57Cholinergic synapse_Homo sapiens_hsa047250.91735794
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91609896
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90241821
60Glioma_Homo sapiens_hsa052140.89025381
61cAMP signaling pathway_Homo sapiens_hsa040240.87793775
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.87644967
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.86990083
64GnRH signaling pathway_Homo sapiens_hsa049120.82280800
65Basal transcription factors_Homo sapiens_hsa030220.81168271
66PPAR signaling pathway_Homo sapiens_hsa033200.80290081
67Protein digestion and absorption_Homo sapiens_hsa049740.79553284
68Phenylalanine metabolism_Homo sapiens_hsa003600.78151260
69Huntingtons disease_Homo sapiens_hsa050160.77978243
70ErbB signaling pathway_Homo sapiens_hsa040120.76296890
71Tight junction_Homo sapiens_hsa045300.75960075
72Pancreatic secretion_Homo sapiens_hsa049720.75825586
73Thyroid hormone synthesis_Homo sapiens_hsa049180.74353550
74Notch signaling pathway_Homo sapiens_hsa043300.73877946
75Type II diabetes mellitus_Homo sapiens_hsa049300.73688255
76Fanconi anemia pathway_Homo sapiens_hsa034600.73464079
77Butanoate metabolism_Homo sapiens_hsa006500.72406514
78Endocytosis_Homo sapiens_hsa041440.68550379
79Carbon metabolism_Homo sapiens_hsa012000.67130271
80Purine metabolism_Homo sapiens_hsa002300.65425072
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65108134
82mRNA surveillance pathway_Homo sapiens_hsa030150.65013966
83Arginine biosynthesis_Homo sapiens_hsa002200.64137503
84Inositol phosphate metabolism_Homo sapiens_hsa005620.63277449
85mTOR signaling pathway_Homo sapiens_hsa041500.62566561
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61337164
87Insulin signaling pathway_Homo sapiens_hsa049100.60950162
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59994012
89ECM-receptor interaction_Homo sapiens_hsa045120.59758330
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59379563
91Selenocompound metabolism_Homo sapiens_hsa004500.58583070
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.58555074
93Adherens junction_Homo sapiens_hsa045200.57938332
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.55849009
95Bile secretion_Homo sapiens_hsa049760.55785692
96Hedgehog signaling pathway_Homo sapiens_hsa043400.55507034
97Acute myeloid leukemia_Homo sapiens_hsa052210.54425948
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53357689
99Endometrial cancer_Homo sapiens_hsa052130.53313827
100Serotonergic synapse_Homo sapiens_hsa047260.53252948
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.51098635
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50856647
103Biosynthesis of amino acids_Homo sapiens_hsa012300.50296658
104ABC transporters_Homo sapiens_hsa020100.48883205
105Non-small cell lung cancer_Homo sapiens_hsa052230.48197343
106AMPK signaling pathway_Homo sapiens_hsa041520.48001991
107Long-term depression_Homo sapiens_hsa047300.47938081
108Wnt signaling pathway_Homo sapiens_hsa043100.47285728
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46783366
110Rap1 signaling pathway_Homo sapiens_hsa040150.46536187
111Arginine and proline metabolism_Homo sapiens_hsa003300.46461916
112Focal adhesion_Homo sapiens_hsa045100.45235152
113Hippo signaling pathway_Homo sapiens_hsa043900.44970114
114VEGF signaling pathway_Homo sapiens_hsa043700.43633208
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43436191
116Fat digestion and absorption_Homo sapiens_hsa049750.42889769
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.42598163
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40285717
119Fatty acid metabolism_Homo sapiens_hsa012120.40236375
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38822201
121Thyroid cancer_Homo sapiens_hsa052160.38619397
122Circadian rhythm_Homo sapiens_hsa047100.38203501
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38065590
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.36958651
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.36916155
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36874021
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36113306
128MAPK signaling pathway_Homo sapiens_hsa040100.35969494
129Axon guidance_Homo sapiens_hsa043600.31728748
130HIF-1 signaling pathway_Homo sapiens_hsa040660.28116154
131Gap junction_Homo sapiens_hsa045400.27919046
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25651772
133B cell receptor signaling pathway_Homo sapiens_hsa046620.23922195

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