TRIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)6.32029079
2axon ensheathment in central nervous system (GO:0032291)5.61661842
3central nervous system myelination (GO:0022010)5.61661842
4neuron cell-cell adhesion (GO:0007158)4.50287359
5glutamate secretion (GO:0014047)4.43556882
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.30712633
7presynaptic membrane assembly (GO:0097105)4.23594030
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.13480693
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13082563
10neurotransmitter-gated ion channel clustering (GO:0072578)4.06110039
11nucleobase catabolic process (GO:0046113)4.04250534
12presynaptic membrane organization (GO:0097090)4.02801913
13limb bud formation (GO:0060174)3.91720341
14neuronal action potential propagation (GO:0019227)3.91054841
15neuron recognition (GO:0008038)3.89332219
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.88790419
17dendritic spine morphogenesis (GO:0060997)3.87708772
18cranial nerve morphogenesis (GO:0021602)3.87375870
19regulation of synaptic vesicle exocytosis (GO:2000300)3.86844677
20postsynaptic membrane organization (GO:0001941)3.85179889
21vocalization behavior (GO:0071625)3.77542287
22protein localization to synapse (GO:0035418)3.72506131
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.68901888
24cellular potassium ion homeostasis (GO:0030007)3.67397087
25neurotransmitter secretion (GO:0007269)3.62365908
26metanephric tubule development (GO:0072170)3.59850931
27metanephric nephron tubule development (GO:0072234)3.59850931
28regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.57550903
29axonal fasciculation (GO:0007413)3.56308204
30auditory behavior (GO:0031223)3.56228187
31glutamate receptor signaling pathway (GO:0007215)3.54151278
32cerebellar granule cell differentiation (GO:0021707)3.48796799
33sodium ion export (GO:0071436)3.48266336
34neuronal ion channel clustering (GO:0045161)3.47901315
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.46941921
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46744535
37establishment of mitochondrion localization (GO:0051654)3.44603366
38negative regulation of Ras GTPase activity (GO:0034261)3.41074015
39negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.36421858
40regulation of synaptic vesicle transport (GO:1902803)3.36123656
41cell migration in hindbrain (GO:0021535)3.34100533
42layer formation in cerebral cortex (GO:0021819)3.33528268
43regulation of glutamate receptor signaling pathway (GO:1900449)3.32989800
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.27791985
45metanephric nephron epithelium development (GO:0072243)3.27075803
46synapse assembly (GO:0007416)3.26845514
47regulation of synapse structural plasticity (GO:0051823)3.23877288
48positive regulation of synapse maturation (GO:0090129)3.20565471
49positive regulation of synapse assembly (GO:0051965)3.17498473
50locomotory exploration behavior (GO:0035641)3.13661586
51response to auditory stimulus (GO:0010996)3.12436277
52positive regulation of gastrulation (GO:2000543)3.12365920
53response to methylmercury (GO:0051597)3.07054998
54cellular sodium ion homeostasis (GO:0006883)3.05904729
55retina layer formation (GO:0010842)3.04152697
56positive regulation of dendritic spine development (GO:0060999)3.03425794
57positive regulation of dendritic spine morphogenesis (GO:0061003)2.98422119
58regulation of synaptic transmission, glutamatergic (GO:0051966)2.97467243
59metanephric epithelium development (GO:0072207)2.97193100
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97192079
61neurotransmitter transport (GO:0006836)2.97092852
62long-term memory (GO:0007616)2.96563712
63transmission of nerve impulse (GO:0019226)2.96296536
64regulation of dendritic spine morphogenesis (GO:0061001)2.94998258
65regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94985637
66mating behavior (GO:0007617)2.94498509
67negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.94248245
68mechanosensory behavior (GO:0007638)2.94188308
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93796386
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93227826
71regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93027199
72collecting duct development (GO:0072044)2.92736132
73ephrin receptor signaling pathway (GO:0048013)2.92145598
74cerebral cortex radially oriented cell migration (GO:0021799)2.91592125
75synaptic transmission, glutamatergic (GO:0035249)2.89965433
76central nervous system projection neuron axonogenesis (GO:0021952)2.88732217
77adult walking behavior (GO:0007628)2.87198440
78negative regulation of neurotransmitter transport (GO:0051589)2.86522220
79dendrite morphogenesis (GO:0048813)2.86254883
80regulation of synaptic transmission, GABAergic (GO:0032228)2.85079069
81regulation of somitogenesis (GO:0014807)2.84861087
82membrane depolarization during action potential (GO:0086010)2.84626482
83cranial nerve structural organization (GO:0021604)2.84028623
84membrane assembly (GO:0071709)2.83842302
85lateral sprouting from an epithelium (GO:0060601)2.83006571
86eyelid development in camera-type eye (GO:0061029)2.82405691
87pattern specification involved in kidney development (GO:0061004)2.82390580
88synapse organization (GO:0050808)2.82074778
89myelination (GO:0042552)2.81915700
90regulation of dendritic spine development (GO:0060998)2.80067718
91cell communication by electrical coupling (GO:0010644)2.79709214
92regulation of neurotransmitter levels (GO:0001505)2.79277639
93exploration behavior (GO:0035640)2.78807182
94regulation of respiratory system process (GO:0044065)2.78774705
95axon ensheathment (GO:0008366)2.78284079
96ensheathment of neurons (GO:0007272)2.78284079
97negative regulation of dendrite development (GO:2000171)2.77894207
98regulation of neuronal synaptic plasticity (GO:0048168)2.77640691
99positive regulation of protein kinase C signaling (GO:0090037)2.77231178
100regulation of vesicle fusion (GO:0031338)2.76953004
101positive regulation of membrane potential (GO:0045838)2.76796754
102central nervous system neuron axonogenesis (GO:0021955)2.75726113
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75574875
104pyrimidine nucleobase catabolic process (GO:0006208)2.74804721
105sympathetic nervous system development (GO:0048485)2.73254679
106oligodendrocyte differentiation (GO:0048709)2.72756810
107negative regulation of axon extension (GO:0030517)2.72499047
108neuron-neuron synaptic transmission (GO:0007270)2.72349607
109nephron tubule development (GO:0072080)2.72334839
110facial nerve structural organization (GO:0021612)2.72081481
111regulation of axon extension involved in axon guidance (GO:0048841)2.72021698
112regulation of neurotransmitter secretion (GO:0046928)2.71282151
113synaptic vesicle endocytosis (GO:0048488)2.71025261
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.70119159
115L-amino acid import (GO:0043092)2.68908444
116long-chain fatty acid biosynthetic process (GO:0042759)2.68892774
117inner ear receptor cell development (GO:0060119)2.68519318
118mitochondrion transport along microtubule (GO:0047497)2.67386788
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67386788
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66891605
121negative regulation of axon extension involved in axon guidance (GO:0048843)2.65516427
122cell communication involved in cardiac conduction (GO:0086065)2.65365134
123potassium ion homeostasis (GO:0055075)2.64414215
124regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63880964
125cerebellar Purkinje cell differentiation (GO:0021702)2.63604633
126eye photoreceptor cell differentiation (GO:0001754)2.63269735
127photoreceptor cell differentiation (GO:0046530)2.63269735
128axonogenesis (GO:0007409)2.63164445
129acidic amino acid transport (GO:0015800)2.61939806
130amino acid import (GO:0043090)2.61285876
131synaptic vesicle maturation (GO:0016188)2.61278798
132negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60335310
133embryonic body morphogenesis (GO:0010172)2.58428579
134gamma-aminobutyric acid transport (GO:0015812)2.58183659
135regulation of synapse assembly (GO:0051963)2.56773825
136spinal cord development (GO:0021510)2.56581767
137startle response (GO:0001964)2.55721691
138synaptic vesicle exocytosis (GO:0016079)2.55293468
139negative regulation of protein localization to cell surface (GO:2000009)2.54986887
140behavioral fear response (GO:0001662)2.54419918
141behavioral defense response (GO:0002209)2.54419918
142positive regulation of meiosis (GO:0045836)2.54400229
143forebrain neuron development (GO:0021884)2.53769554
144righting reflex (GO:0060013)2.53363684
145regulation of postsynaptic membrane potential (GO:0060078)2.53061513
146regulation of axon guidance (GO:1902667)2.52214170
147nephron epithelium development (GO:0072009)2.52195147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63925497
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.64788039
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.37963086
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.35922239
5EZH2_18974828_ChIP-Seq_MESCs_Mouse3.31557896
6RNF2_18974828_ChIP-Seq_MESCs_Mouse3.31557896
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27145496
8EED_16625203_ChIP-ChIP_MESCs_Mouse3.25662355
9JARID2_20075857_ChIP-Seq_MESCs_Mouse3.17234425
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.13871796
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.10487226
12GBX2_23144817_ChIP-Seq_PC3_Human2.86102626
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.85574864
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.62233720
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.58442145
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.55391542
17AR_21572438_ChIP-Seq_LNCaP_Human2.51246175
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.50324581
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46705781
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.44471212
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.30994456
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29738005
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29085063
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19330525
25TAF15_26573619_Chip-Seq_HEK293_Human1.83134286
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82942713
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82401975
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73432583
29RING1B_27294783_Chip-Seq_NPCs_Mouse1.70966206
30RING1B_27294783_Chip-Seq_ESCs_Mouse1.69974528
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.67812210
32* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67791747
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.66896026
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66196711
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65547501
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62065700
37REST_21632747_ChIP-Seq_MESCs_Mouse1.60268759
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59530860
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57159565
40DROSHA_22980978_ChIP-Seq_HELA_Human1.55805331
41* RNF2_27304074_Chip-Seq_NSC_Mouse1.54925944
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50264477
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49892753
44ZNF274_21170338_ChIP-Seq_K562_Hela1.45666635
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45004672
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.43470682
47VDR_22108803_ChIP-Seq_LS180_Human1.42367036
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.39517100
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35964749
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.34837592
51* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33796862
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33167204
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31956829
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31599766
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31559090
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31114542
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30491469
58P300_19829295_ChIP-Seq_ESCs_Human1.28842568
59TCF4_23295773_ChIP-Seq_U87_Human1.28016095
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.26668862
61* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24751456
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24010005
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22523164
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22062090
65LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21777796
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21579907
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21242919
68* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20062834
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16908920
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16658528
71SMAD4_21799915_ChIP-Seq_A2780_Human1.14811023
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13300932
73FUS_26573619_Chip-Seq_HEK293_Human1.11531343
74SOX9_26525672_Chip-Seq_HEART_Mouse1.11329542
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09917946
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08842614
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07020491
78AHR_22903824_ChIP-Seq_MCF-7_Human1.06330781
79EWS_26573619_Chip-Seq_HEK293_Human1.05924656
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.05639271
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05587865
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.04762923
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04317461
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03946878
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02889952
86CBP_20019798_ChIP-Seq_JUKART_Human1.02889952
87* P53_22387025_ChIP-Seq_ESCs_Mouse1.02132978
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01730197
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.01280870
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01088171
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00704195
92KDM2B_26808549_Chip-Seq_REH_Human1.00232364
93ER_23166858_ChIP-Seq_MCF-7_Human0.99055524
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97089996
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95936725
96TP53_18474530_ChIP-ChIP_U2OS_Human0.95232972
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95161819
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91998036
99AR_25329375_ChIP-Seq_VCAP_Human0.91449704
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90996279
101IGF1R_20145208_ChIP-Seq_DFB_Human0.90556762
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90476101
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89780267
104* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89339369
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89237547
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88889998
107RUNX2_22187159_ChIP-Seq_PCA_Human0.88069745
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87232448
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86659291
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86659291
111KDM2B_26808549_Chip-Seq_K562_Human0.86500096
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86205014
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84660552
114CTCF_27219007_Chip-Seq_Bcells_Human0.84111081
115* STAT3_23295773_ChIP-Seq_U87_Human0.84025220
116AR_19668381_ChIP-Seq_PC3_Human0.83393238
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.82883215
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.82427437
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81146477
120YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80964955
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80454375
122* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80059446
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79600528
124* SMAD3_21741376_ChIP-Seq_HESCs_Human0.79219844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.28336806
2MP0003136_yellow_coat_color3.62272222
3MP0004859_abnormal_synaptic_plasticity3.58797339
4MP0004270_analgesia2.96634505
5MP0005409_darkened_coat_color2.89544081
6MP0000778_abnormal_nervous_system2.78184814
7MP0003635_abnormal_synaptic_transmissio2.46854396
8MP0001968_abnormal_touch/_nociception2.41833717
9MP0005423_abnormal_somatic_nervous2.35037901
10MP0004381_abnormal_hair_follicle2.27520635
11MP0002822_catalepsy2.23321943
12MP0001984_abnormal_olfaction2.12143764
13MP0001188_hyperpigmentation2.07078461
14MP0009745_abnormal_behavioral_response2.01892493
15MP0001486_abnormal_startle_reflex1.99039281
16* MP0002064_seizures1.97656316
17MP0002272_abnormal_nervous_system1.97068354
18MP0002734_abnormal_mechanical_nocicepti1.93945002
19MP0004742_abnormal_vestibular_system1.89002672
20MP0003787_abnormal_imprinting1.87893867
21MP0003938_abnormal_ear_development1.87477963
22MP0002063_abnormal_learning/memory/cond1.86970942
23MP0003385_abnormal_body_wall1.84365570
24MP0000049_abnormal_middle_ear1.79146070
25MP0009046_muscle_twitch1.75404528
26MP0002067_abnormal_sensory_capabilities1.74895651
27MP0002249_abnormal_larynx_morphology1.73387440
28MP0009250_abnormal_appendicular_skeleto1.72735301
29MP0002736_abnormal_nociception_after1.70157440
30MP0002184_abnormal_innervation1.66865335
31MP0002572_abnormal_emotion/affect_behav1.66495259
32MP0000569_abnormal_digit_pigmentation1.66488652
33MP0009379_abnormal_foot_pigmentation1.62411234
34MP0005174_abnormal_tail_pigmentation1.61311132
35MP0000566_synostosis1.55441129
36MP0002102_abnormal_ear_morphology1.54949768
37MP0004885_abnormal_endolymph1.51923942
38MP0002557_abnormal_social/conspecific_i1.48076911
39MP0000920_abnormal_myelination1.46672043
40MP0002751_abnormal_autonomic_nervous1.46227971
41MP0003315_abnormal_perineum_morphology1.45342716
42MP0000955_abnormal_spinal_cord1.45237089
43* MP0002882_abnormal_neuron_morphology1.44933582
44MP0003011_delayed_dark_adaptation1.44733854
45MP0002938_white_spotting1.43424279
46MP0006276_abnormal_autonomic_nervous1.43404328
47MP0002638_abnormal_pupillary_reflex1.41053189
48MP0010386_abnormal_urinary_bladder1.40492684
49MP0001440_abnormal_grooming_behavior1.40327537
50MP0004142_abnormal_muscle_tone1.39353400
51MP0000631_abnormal_neuroendocrine_gland1.36694104
52MP0001970_abnormal_pain_threshold1.33866752
53MP0002735_abnormal_chemical_nociception1.30389243
54MP0000026_abnormal_inner_ear1.28447753
55MP0001502_abnormal_circadian_rhythm1.27741166
56MP0005171_absent_coat_pigmentation1.27449480
57* MP0002752_abnormal_somatic_nervous1.26677700
58MP0003121_genomic_imprinting1.25734259
59MP0002282_abnormal_trachea_morphology1.23976799
60MP0002733_abnormal_thermal_nociception1.22913594
61MP0001177_atelectasis1.21244226
62MP0003633_abnormal_nervous_system1.21143994
63MP0008569_lethality_at_weaning1.20240301
64MP0000467_abnormal_esophagus_morphology1.19670376
65* MP0002152_abnormal_brain_morphology1.19152322
66MP0002909_abnormal_adrenal_gland1.17354586
67MP0003937_abnormal_limbs/digits/tail_de1.17155756
68MP0001905_abnormal_dopamine_level1.16789366
69MP0000537_abnormal_urethra_morphology1.15907275
70MP0002653_abnormal_ependyma_morphology1.15336074
71MP0002177_abnormal_outer_ear1.14747686
72MP0001501_abnormal_sleep_pattern1.14179236
73MP0009780_abnormal_chondrocyte_physiolo1.13791534
74MP0003755_abnormal_palate_morphology1.13689099
75MP0000762_abnormal_tongue_morphology1.11797088
76MP0008789_abnormal_olfactory_epithelium1.11690470
77MP0003879_abnormal_hair_cell1.11160596
78MP0004145_abnormal_muscle_electrophysio1.11159662
79MP0005257_abnormal_intraocular_pressure1.10984138
80MP0005646_abnormal_pituitary_gland1.10960859
81* MP0002066_abnormal_motor_capabilities/c1.10896257
82MP0005394_taste/olfaction_phenotype1.10042198
83MP0005499_abnormal_olfactory_system1.10042198
84MP0000428_abnormal_craniofacial_morphol1.09090022
85MP0003861_abnormal_nervous_system1.08255817
86MP0003631_nervous_system_phenotype1.06278196
87MP0001299_abnormal_eye_distance/1.06035263
88MP0005645_abnormal_hypothalamus_physiol1.05297496
89MP0003283_abnormal_digestive_organ1.04756236
90MP0003634_abnormal_glial_cell1.03567306
91MP0004858_abnormal_nervous_system1.03359610
92MP0001340_abnormal_eyelid_morphology1.02952303
93MP0001346_abnormal_lacrimal_gland1.01792479
94MP0001963_abnormal_hearing_physiology1.01633706
95MP0005187_abnormal_penis_morphology1.01601476
96MP0005551_abnormal_eye_electrophysiolog1.00174937
97MP0004043_abnormal_pH_regulation0.99748443
98MP0003690_abnormal_glial_cell0.99697220
99MP0006292_abnormal_olfactory_placode0.98078320
100MP0003942_abnormal_urinary_system0.97593781
101MP0005623_abnormal_meninges_morphology0.96600645
102MP0003632_abnormal_nervous_system0.96557548
103MP0001485_abnormal_pinna_reflex0.95855150
104MP0003890_abnormal_embryonic-extraembry0.95638734
105MP0005248_abnormal_Harderian_gland0.95570352
106MP0009053_abnormal_anal_canal0.93076364
107MP0003119_abnormal_digestive_system0.93025738
108MP0003329_amyloid_beta_deposits0.92588051
109MP0002233_abnormal_nose_morphology0.92380985
110MP0004811_abnormal_neuron_physiology0.92363580
111MP0000372_irregular_coat_pigmentation0.91693737
112MP0004133_heterotaxia0.91578068
113MP0002116_abnormal_craniofacial_bone0.91250619
114MP0002234_abnormal_pharynx_morphology0.90292393
115MP0001529_abnormal_vocalization0.90253429
116MP0005386_behavior/neurological_phenoty0.88268014
117MP0004924_abnormal_behavior0.88268014
118MP0005253_abnormal_eye_physiology0.86700924
119MP0002069_abnormal_eating/drinking_beha0.85581998
120MP0000534_abnormal_ureter_morphology0.85581047
121MP0003123_paternal_imprinting0.84844945
122MP0003137_abnormal_impulse_conducting0.83072561
123MP0006072_abnormal_retinal_apoptosis0.82221344
124MP0003935_abnormal_craniofacial_develop0.81528289
125MP0000751_myopathy0.79530354
126* MP0002229_neurodegeneration0.79381354
127MP0000462_abnormal_digestive_system0.79210068
128MP0003122_maternal_imprinting0.76378559
129MP0002081_perinatal_lethality0.76065653
130MP0000579_abnormal_nail_morphology0.72982395
131MP0002082_postnatal_lethality0.69694061
132MP0010770_preweaning_lethality0.69694061
133MP0010769_abnormal_survival0.66971747

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.01608946
2Focal motor seizures (HP:0011153)4.09579535
3Obstructive sleep apnea (HP:0002870)4.00922171
4Alacrima (HP:0000522)3.67892112
5Myokymia (HP:0002411)3.66736274
6Chin dimple (HP:0010751)3.64122564
7Abnormality of the axillary hair (HP:0100134)3.55661209
8Abnormality of secondary sexual hair (HP:0009888)3.55661209
9Limb dystonia (HP:0002451)3.26815487
10Neurofibrillary tangles (HP:0002185)3.25027842
11Sex reversal (HP:0012245)3.16352174
12Abnormal sex determination (HP:0012244)3.16352174
13Megalencephaly (HP:0001355)3.04892594
14Decreased lacrimation (HP:0000633)2.92008016
15Degeneration of the lateral corticospinal tracts (HP:0002314)2.91998747
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.91998747
17Cerebral inclusion bodies (HP:0100314)2.90528839
18Absent speech (HP:0001344)2.90300208
19Coronal craniosynostosis (HP:0004440)2.89714914
20Supranuclear gaze palsy (HP:0000605)2.82838601
21Focal seizures (HP:0007359)2.78005640
22Epileptiform EEG discharges (HP:0011182)2.74791247
23Ridged nail (HP:0001807)2.72321146
24Impaired vibration sensation in the lower limbs (HP:0002166)2.66148760
25Abnormal eating behavior (HP:0100738)2.61795941
26Urinary urgency (HP:0000012)2.61267483
27Sensory axonal neuropathy (HP:0003390)2.59971802
28Bronchomalacia (HP:0002780)2.58171221
29Ankle clonus (HP:0011448)2.56376644
30EEG with generalized epileptiform discharges (HP:0011198)2.54644698
31Hepatoblastoma (HP:0002884)2.50570718
32Polyphagia (HP:0002591)2.50282498
33Intellectual disability, moderate (HP:0002342)2.48610653
34Sleep apnea (HP:0010535)2.48302891
35Hypsarrhythmia (HP:0002521)2.47949566
36Urinary bladder sphincter dysfunction (HP:0002839)2.47770807
37Abnormality of the corticospinal tract (HP:0002492)2.47224426
38Agitation (HP:0000713)2.46379216
39Restlessness (HP:0000711)2.44434910
40Epileptic encephalopathy (HP:0200134)2.42103318
41Hyperventilation (HP:0002883)2.36828608
42Nephronophthisis (HP:0000090)2.35446599
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33721596
44Gait imbalance (HP:0002141)2.30878047
45Fragile nails (HP:0001808)2.28827307
46Diplopia (HP:0000651)2.27175184
47Abnormality of binocular vision (HP:0011514)2.27175184
48Parakeratosis (HP:0001036)2.26407420
49Midline defect of the nose (HP:0004122)2.26008591
50Hypophosphatemic rickets (HP:0004912)2.24318688
51Abnormality of the lower motor neuron (HP:0002366)2.24143893
52Pheochromocytoma (HP:0002666)2.23468159
53Increased circulating renin level (HP:0000848)2.22019236
54* Broad-based gait (HP:0002136)2.21491731
55Aplasia involving bones of the extremities (HP:0009825)2.21240475
56Aplasia involving bones of the upper limbs (HP:0009823)2.21240475
57Aplasia of the phalanges of the hand (HP:0009802)2.21240475
58Hemiparesis (HP:0001269)2.20275108
59Truncal ataxia (HP:0002078)2.20048175
60Peripheral hypomyelination (HP:0007182)2.19271159
61Insidious onset (HP:0003587)2.18044726
62Termporal pattern (HP:0011008)2.18044726
63Dysmetria (HP:0001310)2.17975005
64Papillary thyroid carcinoma (HP:0002895)2.15363184
65Poor eye contact (HP:0000817)2.14435336
66Esotropia (HP:0000565)2.13599327
67Thickened helices (HP:0000391)2.10961066
68Cutaneous finger syndactyly (HP:0010554)2.10829157
69Lower limb muscle weakness (HP:0007340)2.10044038
70Impaired social interactions (HP:0000735)2.08299930
71Abnormal social behavior (HP:0012433)2.08299930
72Synostosis involving the elbow (HP:0003938)2.08256667
73Humeroradial synostosis (HP:0003041)2.08256667
74Arnold-Chiari malformation (HP:0002308)2.05959631
75Morphological abnormality of the pyramidal tract (HP:0002062)2.03425179
76Mixed hearing impairment (HP:0000410)2.01360677
77Abnormality of the labia minora (HP:0012880)2.01070885
78Septo-optic dysplasia (HP:0100842)1.99724523
79Amyotrophic lateral sclerosis (HP:0007354)1.99584488
80Progressive cerebellar ataxia (HP:0002073)1.99467258
81Protruding tongue (HP:0010808)1.98958035
82Torticollis (HP:0000473)1.98736512
83Esophageal atresia (HP:0002032)1.98605533
84Myelomeningocele (HP:0002475)1.98228115
85Excessive salivation (HP:0003781)1.97354401
86Drooling (HP:0002307)1.97354401
87Gaze-evoked nystagmus (HP:0000640)1.96780897
88Fibular aplasia (HP:0002990)1.94682860
89Action tremor (HP:0002345)1.94065236
90Hypoplastic pelvis (HP:0008839)1.94042513
91Amblyopia (HP:0000646)1.94002425
92Genetic anticipation (HP:0003743)1.92517913
93Achilles tendon contracture (HP:0001771)1.90788724
94Atonic seizures (HP:0010819)1.90561012
95Symphalangism affecting the phalanges of the hand (HP:0009773)1.89286473
96Specific learning disability (HP:0001328)1.88611806
97Bowel incontinence (HP:0002607)1.88461835
98Intention tremor (HP:0002080)1.87733755
99Hypoplasia of the corpus callosum (HP:0002079)1.86541621
100Abnormality of the septum pellucidum (HP:0007375)1.85684891
101Abnormality of the middle phalanges of the toes (HP:0010183)1.85581832
102Optic disc pallor (HP:0000543)1.85367228
103Abnormality of the phalanges of the hallux (HP:0010057)1.85201475
104Abnormality of salivation (HP:0100755)1.84654978
105Dysdiadochokinesis (HP:0002075)1.84635004
106Tracheomalacia (HP:0002779)1.84359128
107Split foot (HP:0001839)1.83286209
108Febrile seizures (HP:0002373)1.82908552
109Deep palmar crease (HP:0006191)1.82802377
110Optic nerve hypoplasia (HP:0000609)1.82653125
111Overgrowth (HP:0001548)1.81975274
112Absent septum pellucidum (HP:0001331)1.81111293
113Dialeptic seizures (HP:0011146)1.81062198
114Cutaneous syndactyly (HP:0012725)1.79936956
115Vaginal atresia (HP:0000148)1.79867798
116Abnormal large intestine physiology (HP:0012700)1.79284691
117Anophthalmia (HP:0000528)1.79270160
118Status epilepticus (HP:0002133)1.78992701
119Aqueductal stenosis (HP:0002410)1.78197949
120Genital tract atresia (HP:0001827)1.77527327
121Aplasia/hypoplasia of the uterus (HP:0008684)1.77025478
122Neuroendocrine neoplasm (HP:0100634)1.75425290
123Spastic tetraplegia (HP:0002510)1.75364714
124Congenital primary aphakia (HP:0007707)1.75118093
125Visual hallucinations (HP:0002367)1.74920687
126Cupped ear (HP:0000378)1.74669126
127Spastic gait (HP:0002064)1.73958852
128Absence seizures (HP:0002121)1.73862919
129Anxiety (HP:0000739)1.72286391
130Bifid scrotum (HP:0000048)1.72030928
131Scanning speech (HP:0002168)1.71788843
132Shallow orbits (HP:0000586)1.71594071
133Hyperaldosteronism (HP:0000859)1.71589274
134Postural instability (HP:0002172)1.70525190
135Lissencephaly (HP:0001339)1.70275622
136Hyperactive renin-angiotensin system (HP:0000841)1.70098593
137Generalized tonic-clonic seizures (HP:0002069)1.70038935
138Blue irides (HP:0000635)1.69741145
139Morphological abnormality of the middle ear (HP:0008609)1.68912879
140Limited hip movement (HP:0008800)1.68791421
141Medial flaring of the eyebrow (HP:0010747)1.68726197
142Mutism (HP:0002300)1.67677852
143Abnormality of the Achilles tendon (HP:0005109)1.67205637
144Akinesia (HP:0002304)1.66862685
145Retinal dysplasia (HP:0007973)1.66322620
146Impaired vibratory sensation (HP:0002495)1.66100552
147Exotropia (HP:0000577)1.65078324
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65067184
149Cortical dysplasia (HP:0002539)1.64587910
150Nephrogenic diabetes insipidus (HP:0009806)1.62397218
151Inability to walk (HP:0002540)1.61393912
152True hermaphroditism (HP:0010459)1.59650784
153Hemiplegia (HP:0002301)1.59016060
154Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58104551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.17537611
2TLK16.43067305
3MKNK23.59417845
4NTRK32.78232841
5EPHA42.53618907
6MARK12.28883383
7WNK32.25450087
8STK392.10757023
9MKNK11.95323782
10PKN11.92870158
11EPHB21.85033718
12UHMK11.77845626
13PNCK1.75030168
14CDK191.56151373
15EPHA31.52316495
16OXSR11.47130841
17MAPK131.45858876
18NTRK11.43483329
19NTRK21.40977883
20PHKG21.37372799
21PHKG11.37372799
22TNIK1.33831750
23SRPK11.32902128
24SGK21.30559810
25FRK1.30373025
26PAK61.20788442
27PRPF4B1.20368548
28CAMK2B1.18682444
29PINK11.17097225
30FES1.12882799
31MAP3K41.12881232
32DAPK31.12620145
33ROCK21.11812169
34MAP2K71.11389775
35CDK51.11271227
36ERBB31.08088612
37PRKD31.06423037
38FGR1.05074415
39WNK11.03357479
40DYRK1A1.02372149
41TRIM281.00367748
42LMTK20.99508409
43CAMKK10.96298391
44MINK10.95801269
45CAMK2A0.93589952
46DYRK20.89618742
47MAP4K20.87955908
48CLK10.86058503
49BMPR1B0.83484435
50CCNB10.78928078
51CSNK1G20.78553332
52CSNK1G10.76376069
53LATS20.76298443
54PAK20.74958994
55NME10.74778579
56KSR10.73522613
57CAMKK20.73464306
58CSNK1A1L0.73426380
59STK110.72306661
60MAP3K90.72147340
61SGK30.71576545
62SGK10.71327328
63RIPK40.70760925
64MARK20.70602857
65ILK0.69571370
66CSNK1G30.69316735
67DAPK20.68453706
68WNK40.67740024
69CDK140.67628450
70PRKCG0.66970511
71PLK20.66553658
72FGFR20.65592865
73PAK30.64978036
74SIK20.64102107
75PRKCE0.64009891
76AKT30.63599457
77BLK0.63479919
78FER0.63336758
79CAMK1G0.62507553
80LATS10.62497298
81CAMK2G0.60603169
82CAMK2D0.59985208
83SGK4940.58867574
84SGK2230.58867574
85DDR20.58049248
86STK38L0.56954038
87PRKD10.56169417
88PRKD20.56007174
89MAP2K40.55775283
90CDK150.55770487
91CSNK1E0.55121349
92GRK50.55105212
93DMPK0.54537634
94CDK11A0.54140286
95GRK70.54019177
96BCR0.53981525
97MAPKAPK50.53290091
98TYRO30.52741795
99CDK180.52364495
100MET0.51330767
101ICK0.50906576
102PRKCH0.49352676
103CSNK1D0.48531205
104FYN0.47858757
105RPS6KA30.47747820
106PRKG10.46513127
107ROCK10.46089156
108CAMK40.45525215
109MAPK100.44098166
110PTK2B0.43878050
111IRAK20.43575057
112CDK30.43106649
113YES10.42549634
114DAPK10.42314447
115MAP2K20.41244178
116PRKCZ0.40997698
117ERBB20.40618691
118MAPK150.40320674
119CSNK1A10.39920522
120GSK3A0.38516366
121LIMK10.37712107
122MAP3K10.37709446
123CAMK10.35626311
124PRKAA10.32796373
125PRKACA0.31780434
126PRKACB0.31387498
127RET0.30605301
128GSK3B0.29427251

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.25129038
2Axon guidance_Homo sapiens_hsa043602.65258415
3Glutamatergic synapse_Homo sapiens_hsa047242.51797415
4Long-term depression_Homo sapiens_hsa047302.28232197
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26637323
6GABAergic synapse_Homo sapiens_hsa047272.15264108
7Long-term potentiation_Homo sapiens_hsa047202.14795514
8Circadian entrainment_Homo sapiens_hsa047132.13423720
9Morphine addiction_Homo sapiens_hsa050322.13073294
10Phototransduction_Homo sapiens_hsa047442.00214794
11Melanogenesis_Homo sapiens_hsa049161.96036517
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94383428
13Salivary secretion_Homo sapiens_hsa049701.90559151
14Serotonergic synapse_Homo sapiens_hsa047261.81544372
15Amphetamine addiction_Homo sapiens_hsa050311.75441668
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72912527
17Olfactory transduction_Homo sapiens_hsa047401.72562431
18Renin secretion_Homo sapiens_hsa049241.69085353
19Dopaminergic synapse_Homo sapiens_hsa047281.67237213
20Synaptic vesicle cycle_Homo sapiens_hsa047211.62237778
21Basal cell carcinoma_Homo sapiens_hsa052171.60353995
22Gap junction_Homo sapiens_hsa045401.59963719
23Hedgehog signaling pathway_Homo sapiens_hsa043401.59343204
24Gastric acid secretion_Homo sapiens_hsa049711.58515256
25Taste transduction_Homo sapiens_hsa047421.57541716
26Cholinergic synapse_Homo sapiens_hsa047251.56391290
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54882664
28Cocaine addiction_Homo sapiens_hsa050301.54386906
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47196183
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37441711
31GnRH signaling pathway_Homo sapiens_hsa049121.37047348
32Wnt signaling pathway_Homo sapiens_hsa043101.35960996
33Oxytocin signaling pathway_Homo sapiens_hsa049211.31346535
34Oxidative phosphorylation_Homo sapiens_hsa001901.31186003
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28805474
36Calcium signaling pathway_Homo sapiens_hsa040201.28780355
37Cardiac muscle contraction_Homo sapiens_hsa042601.28122023
38Insulin secretion_Homo sapiens_hsa049111.27995031
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25709636
40ErbB signaling pathway_Homo sapiens_hsa040121.25482792
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24467219
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21490540
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17087357
44Alzheimers disease_Homo sapiens_hsa050101.17070569
45Sphingolipid metabolism_Homo sapiens_hsa006001.16789101
46Glioma_Homo sapiens_hsa052141.14312258
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09298004
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05901014
49Renal cell carcinoma_Homo sapiens_hsa052111.02439190
50Estrogen signaling pathway_Homo sapiens_hsa049151.02314667
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00713899
52Ether lipid metabolism_Homo sapiens_hsa005650.99168311
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.98117911
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.97575473
55Circadian rhythm_Homo sapiens_hsa047100.96841850
56Ras signaling pathway_Homo sapiens_hsa040140.95058720
57Collecting duct acid secretion_Homo sapiens_hsa049660.94782039
58cAMP signaling pathway_Homo sapiens_hsa040240.93963186
59Bile secretion_Homo sapiens_hsa049760.93294086
60Histidine metabolism_Homo sapiens_hsa003400.87481118
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.86220632
62Vibrio cholerae infection_Homo sapiens_hsa051100.86029973
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85735000
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84737669
65Ribosome_Homo sapiens_hsa030100.84667492
66Parkinsons disease_Homo sapiens_hsa050120.80726779
67Steroid biosynthesis_Homo sapiens_hsa001000.79940510
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77490858
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77150734
70Dorso-ventral axis formation_Homo sapiens_hsa043200.76703597
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74965520
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74427928
73Pancreatic secretion_Homo sapiens_hsa049720.73848281
74Choline metabolism in cancer_Homo sapiens_hsa052310.73347317
75Fatty acid elongation_Homo sapiens_hsa000620.73342936
76Vitamin B6 metabolism_Homo sapiens_hsa007500.72472175
77Tight junction_Homo sapiens_hsa045300.72304888
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71894320
79Rap1 signaling pathway_Homo sapiens_hsa040150.71672694
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71262352
81MAPK signaling pathway_Homo sapiens_hsa040100.68044119
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67552307
83Hippo signaling pathway_Homo sapiens_hsa043900.67188192
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65066164
85beta-Alanine metabolism_Homo sapiens_hsa004100.63930569
86Nitrogen metabolism_Homo sapiens_hsa009100.62427278
87Dilated cardiomyopathy_Homo sapiens_hsa054140.61860664
88Melanoma_Homo sapiens_hsa052180.61754022
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61439903
90VEGF signaling pathway_Homo sapiens_hsa043700.59387480
91Bladder cancer_Homo sapiens_hsa052190.55105434
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51565759
93Endometrial cancer_Homo sapiens_hsa052130.51527626
94Huntingtons disease_Homo sapiens_hsa050160.50787403
95Inositol phosphate metabolism_Homo sapiens_hsa005620.50146773
96Fatty acid biosynthesis_Homo sapiens_hsa000610.50137528
97Adherens junction_Homo sapiens_hsa045200.50100969
98Alcoholism_Homo sapiens_hsa050340.49070824
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48881258
100Ovarian steroidogenesis_Homo sapiens_hsa049130.47404552
101Butanoate metabolism_Homo sapiens_hsa006500.47256521
102Protein digestion and absorption_Homo sapiens_hsa049740.46657292
103Type II diabetes mellitus_Homo sapiens_hsa049300.45808614
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44731372
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.44328527
106Thyroid hormone synthesis_Homo sapiens_hsa049180.43695085
107AMPK signaling pathway_Homo sapiens_hsa041520.42113727
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41596374
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.40265500
110Glucagon signaling pathway_Homo sapiens_hsa049220.39669826
111Oocyte meiosis_Homo sapiens_hsa041140.39391124
112Mineral absorption_Homo sapiens_hsa049780.39213385
113MicroRNAs in cancer_Homo sapiens_hsa052060.38970712
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38124428
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37484945
116Arginine biosynthesis_Homo sapiens_hsa002200.36866638
117Notch signaling pathway_Homo sapiens_hsa043300.35985190
118Sulfur relay system_Homo sapiens_hsa041220.35046346
119Prostate cancer_Homo sapiens_hsa052150.34426259
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34190571
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33994279
122Non-small cell lung cancer_Homo sapiens_hsa052230.33582174

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