TRIM22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.22906631
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.93002693
3negative regulation of cell killing (GO:0031342)5.93002693
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68980516
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.50139430
6antigen processing and presentation of endogenous antigen (GO:0019883)5.34796267
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.13209170
8cellular response to type I interferon (GO:0071357)5.13195114
9type I interferon signaling pathway (GO:0060337)5.13195114
10response to type I interferon (GO:0034340)5.11805804
11regulation of B cell receptor signaling pathway (GO:0050855)5.03090530
12positive regulation by symbiont of host defense response (GO:0052509)4.77195555
13modulation by symbiont of host defense response (GO:0052031)4.77195555
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77195555
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77195555
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.77195555
17modulation by symbiont of host immune response (GO:0052553)4.77195555
18regulation of gamma-delta T cell activation (GO:0046643)4.59886361
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.59361507
20macrophage activation involved in immune response (GO:0002281)4.25375399
21negative regulation of interleukin-12 production (GO:0032695)4.19069257
22detection of other organism (GO:0098543)4.17151833
23negative regulation of T cell mediated immunity (GO:0002710)4.16095479
24immunoglobulin mediated immune response (GO:0016064)4.12006051
25interferon-gamma-mediated signaling pathway (GO:0060333)4.11250927
26regulation of gamma-delta T cell differentiation (GO:0045586)4.10255388
27detection of bacterium (GO:0016045)3.99888748
28T cell migration (GO:0072678)3.95907424
29negative T cell selection (GO:0043383)3.95770225
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.94149085
31negative thymic T cell selection (GO:0045060)3.93205629
32regulation of interferon-beta biosynthetic process (GO:0045357)3.87256866
33B cell receptor signaling pathway (GO:0050853)3.86093638
34response to interleukin-15 (GO:0070672)3.77321965
35response to interferon-alpha (GO:0035455)3.77078335
36detection of molecule of bacterial origin (GO:0032490)3.70425890
37detection of external biotic stimulus (GO:0098581)3.67759653
38positive regulation of interferon-alpha production (GO:0032727)3.66666868
39response to peptidoglycan (GO:0032494)3.66209410
40microglial cell activation (GO:0001774)3.62983322
41cellular response to interleukin-15 (GO:0071350)3.61953748
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60939466
43response to host immune response (GO:0052572)3.60939466
44regulation of interferon-alpha production (GO:0032647)3.58820594
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51425879
46negative regulation of viral genome replication (GO:0045071)3.51208872
47leukocyte aggregation (GO:0070486)3.49872909
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48321930
49positive thymic T cell selection (GO:0045059)3.46497832
50antigen processing and presentation via MHC class Ib (GO:0002475)3.46210092
51neutrophil activation involved in immune response (GO:0002283)3.44971357
52tolerance induction (GO:0002507)3.44663890
53regulation of T cell tolerance induction (GO:0002664)3.43135481
54negative regulation of leukocyte mediated immunity (GO:0002704)3.42570906
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40335753
56response to interferon-beta (GO:0035456)3.39490743
57cellular extravasation (GO:0045123)3.36583858
58regulation of B cell differentiation (GO:0045577)3.36254454
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36223130
60defense response to protozoan (GO:0042832)3.36133539
61regulation of regulatory T cell differentiation (GO:0045589)3.34631279
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32681376
63regulation of T cell mediated cytotoxicity (GO:0001914)3.32460170
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32351895
65response to host (GO:0075136)3.32351895
66response to host defenses (GO:0052200)3.32351895
67regulation of tolerance induction (GO:0002643)3.30693032
68regulation of alpha-beta T cell proliferation (GO:0046640)3.29408433
69B cell mediated immunity (GO:0019724)3.28343430
70positive regulation of B cell differentiation (GO:0045579)3.26929845
71positive T cell selection (GO:0043368)3.22912141
72detection of biotic stimulus (GO:0009595)3.22341006
73regulation of antigen processing and presentation (GO:0002577)3.19123460
74myeloid cell activation involved in immune response (GO:0002275)3.16669924
75T cell selection (GO:0045058)3.13038688
76interferon-gamma production (GO:0032609)3.12438539
77positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10963901
78cellular response to interferon-gamma (GO:0071346)3.09353532
79activated T cell proliferation (GO:0050798)3.06203259
80macrophage activation (GO:0042116)3.05327856
81response to protozoan (GO:0001562)3.03285766
82negative regulation of innate immune response (GO:0045824)3.02554382
83positive regulation of tolerance induction (GO:0002645)3.02245300
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00599684
85positive regulation of antigen processing and presentation (GO:0002579)2.98823482
86positive regulation of type 2 immune response (GO:0002830)2.98641096
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97750553
88positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96905088
89thymic T cell selection (GO:0045061)2.95950088
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94079109
91regulation of MHC class I biosynthetic process (GO:0045343)2.94057010
92regulation of natural killer cell mediated immunity (GO:0002715)2.94029582
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94029582
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93901469
95neutrophil activation (GO:0042119)2.91020542
96response to muramyl dipeptide (GO:0032495)2.90876671
97positive regulation of interferon-beta production (GO:0032728)2.90313036
98germinal center formation (GO:0002467)2.90070096
99cellular response to interferon-alpha (GO:0035457)2.87538521
100response to interferon-gamma (GO:0034341)2.86291581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.92594222
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37939509
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.04521937
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.74801657
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.52713344
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.19106738
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.84758647
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.23720533
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14097177
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05844680
11RUNX_20019798_ChIP-Seq_JUKART_Human3.05756579
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90424330
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.88406129
14MYB_26560356_Chip-Seq_TH2_Human2.69345453
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41578403
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38968842
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32588321
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27679338
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26863144
20SPI1_23547873_ChIP-Seq_NB4_Human2.17418747
21MYB_26560356_Chip-Seq_TH1_Human2.12641546
22SCL_19346495_ChIP-Seq_HPC-7_Human2.07829958
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04273733
24MAF_26560356_Chip-Seq_TH1_Human2.02574775
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97133848
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93494257
27SPI1_23127762_ChIP-Seq_K562_Human1.91565876
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89623989
29* GATA3_27048872_Chip-Seq_THYMUS_Human1.88878154
30VDR_24787735_ChIP-Seq_THP-1_Human1.88219843
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87445758
32VDR_24763502_ChIP-Seq_THP-1_Human1.87339354
33GATA1_22025678_ChIP-Seq_K562_Human1.74644782
34GATA3_26560356_Chip-Seq_TH2_Human1.72888125
35UTX_26944678_Chip-Seq_JUKART_Human1.61418330
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.59946198
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58908543
38VDR_21846776_ChIP-Seq_THP-1_Human1.49172957
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45243537
40MYC_22102868_ChIP-Seq_BL_Human1.42270483
41* MAF_26560356_Chip-Seq_TH2_Human1.35087097
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.31768296
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30753561
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30672207
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29400409
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27528358
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25660348
48PU_27001747_Chip-Seq_BMDM_Mouse1.24778921
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22196218
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.21510428
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21396710
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21362681
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20275223
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19119685
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.17679548
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14251777
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12092729
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11651224
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09313627
60TCF7_22412390_ChIP-Seq_EML_Mouse1.08931886
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06504826
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05277038
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.04937589
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04910900
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03607787
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00952305
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00895946
68SMRT_27268052_Chip-Seq_Bcells_Human1.00610367
69ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97361560
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95539347
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91760214
72GATA1_19941826_ChIP-Seq_K562_Human0.91227045
73* KDM2B_26808549_Chip-Seq_DND41_Human0.89615567
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89458956
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89453706
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87769143
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87586244
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87066142
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87043617
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86984365
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82255423
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78310047
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76971072
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74547347
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.73684885
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72974525
87GATA3_26560356_Chip-Seq_TH1_Human0.72944305
88GATA2_19941826_ChIP-Seq_K562_Human0.72905246
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.71612931
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68063024
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.67884572
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66144664
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65449102
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64529390
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.64406401
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.63783505
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.61311767
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.59653054
99EGR1_19032775_ChIP-ChIP_M12_Human0.59462846
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58724353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.61785675
2MP0001835_abnormal_antigen_presentation4.61090455
3MP0005671_abnormal_response_to3.67231988
4MP0003436_decreased_susceptibility_to3.51968784
5MP0003303_peritoneal_inflammation3.49876225
6MP0001800_abnormal_humoral_immune3.40607493
7MP0009785_altered_susceptibility_to3.28835151
8MP0000685_abnormal_immune_system3.24289010
9MP0001790_abnormal_immune_system3.23881646
10MP0005387_immune_system_phenotype3.23881646
11MP0005000_abnormal_immune_tolerance3.13918998
12MP0005025_abnormal_response_to2.88116216
13MP0002723_abnormal_immune_serum2.85561030
14MP0003763_abnormal_thymus_physiology2.82574711
15MP0006082_CNS_inflammation2.82424096
16MP0002419_abnormal_innate_immunity2.78671331
17MP0002452_abnormal_antigen_presenting2.78050834
18MP0002420_abnormal_adaptive_immunity2.62152138
19MP0001819_abnormal_immune_cell2.60258094
20MP0002148_abnormal_hypersensitivity_rea2.60073467
21MP0003300_gastrointestinal_ulcer2.34727748
22MP0002405_respiratory_system_inflammati2.04569720
23MP0010155_abnormal_intestine_physiology2.03497102
24MP0002398_abnormal_bone_marrow2.02994875
25MP0000716_abnormal_immune_system2.02949278
26MP0002166_altered_tumor_susceptibility1.94387505
27MP0001533_abnormal_skeleton_physiology1.89129730
28MP0001845_abnormal_inflammatory_respons1.84322065
29MP0009333_abnormal_splenocyte_physiolog1.81628338
30MP0005464_abnormal_platelet_physiology1.72168950
31MP0004947_skin_inflammation1.70884688
32MP0000689_abnormal_spleen_morphology1.69490109
33MP0009764_decreased_sensitivity_to1.67021985
34MP0000569_abnormal_digit_pigmentation1.65243610
35MP0002722_abnormal_immune_system1.60056190
36MP0003866_abnormal_defecation1.57635787
37MP0002429_abnormal_blood_cell1.56037878
38MP0008469_abnormal_protein_level1.53881694
39MP0005310_abnormal_salivary_gland1.53116315
40MP0003172_abnormal_lysosome_physiology1.47840759
41MP0000703_abnormal_thymus_morphology1.46948832
42MP0002138_abnormal_hepatobiliary_system1.46938558
43MP0002006_tumorigenesis1.36993060
44MP0000465_gastrointestinal_hemorrhage1.32572670
45MP0003183_abnormal_peptide_metabolism1.31221958
46MP0001873_stomach_inflammation1.28597538
47MP0008260_abnormal_autophagy1.28073850
48MP0004883_abnormal_blood_vessel1.25311666
49MP0002396_abnormal_hematopoietic_system1.21994426
50MP0003191_abnormal_cellular_cholesterol1.21477386
51MP0003828_pulmonary_edema1.19178440
52MP0000858_altered_metastatic_potential1.17215833
53MP0002998_abnormal_bone_remodeling1.14679409
54MP0001853_heart_inflammation1.11441702
55MP0001545_abnormal_hematopoietic_system1.08186580
56MP0005397_hematopoietic_system_phenotyp1.08186580
57MP0005075_abnormal_melanosome_morpholog1.07536814
58MP0002277_abnormal_respiratory_mucosa1.07229879
59MP0009278_abnormal_bone_marrow1.07196910
60MP0002933_joint_inflammation1.04123426
61MP0004381_abnormal_hair_follicle1.03903313
62MP0003045_fibrosis1.03629876
63MP0003448_altered_tumor_morphology1.03098580
64MP0001851_eye_inflammation1.00600567
65MP0002132_abnormal_respiratory_system0.99237766
66MP0005164_abnormal_response_to0.98902637
67MP0009763_increased_sensitivity_to0.98810603
68MP0004510_myositis0.97095254
69MP0003690_abnormal_glial_cell0.93730326
70MP0003075_altered_response_to0.92565062
71MP0005166_decreased_susceptibility_to0.89131476
72MP0001663_abnormal_digestive_system0.88074704
73MP0004808_abnormal_hematopoietic_stem0.86856928
74MP0006054_spinal_hemorrhage0.81030458
75MP0000343_altered_response_to0.78685278
76MP0005390_skeleton_phenotype0.78277770
77MP0000604_amyloidosis0.77225580
78MP0000249_abnormal_blood_vessel0.75977028
79MP0000015_abnormal_ear_pigmentation0.75690276
80MP0002009_preneoplasia0.75362492
81MP0002332_abnormal_exercise_endurance0.74606441
82MP0003091_abnormal_cell_migration0.73326771
83MP0001986_abnormal_taste_sensitivity0.71434612
84MP0005451_abnormal_body_composition0.70267138
85MP0003656_abnormal_erythrocyte_physiolo0.70143033
86MP0009765_abnormal_xenobiotic_induced0.70129146
87MP0005058_abnormal_lysosome_morphology0.66648564
88MP0003252_abnormal_bile_duct0.62619775
89MP0001958_emphysema0.61607644
90MP0003221_abnormal_cardiomyocyte_apopto0.59526299
91MP0008004_abnormal_stomach_pH0.59325403
92MP0000371_diluted_coat_color0.58904555
93MP0003795_abnormal_bone_structure0.57039163
94MP0002693_abnormal_pancreas_physiology0.53838447
95MP0003806_abnormal_nucleotide_metabolis0.53718073
96MP0002136_abnormal_kidney_physiology0.53395237
97MP0002019_abnormal_tumor_incidence0.52107633
98MP0008874_decreased_physiological_sensi0.50731881
99MP0004130_abnormal_muscle_cell0.50073014
100MP0005174_abnormal_tail_pigmentation0.48722361

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.44950321
2Myositis (HP:0100614)5.21975773
3Recurrent bacterial skin infections (HP:0005406)5.20141890
4Retrobulbar optic neuritis (HP:0100654)5.18902235
5Optic neuritis (HP:0100653)5.18902235
6Orchitis (HP:0100796)5.07078772
7Recurrent abscess formation (HP:0002722)4.94419649
8Elevated erythrocyte sedimentation rate (HP:0003565)4.70243331
9Recurrent fungal infections (HP:0002841)4.67473380
10Recurrent cutaneous fungal infections (HP:0011370)4.63972567
11Chronic mucocutaneous candidiasis (HP:0002728)4.63972567
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.63840987
13T lymphocytopenia (HP:0005403)4.60913107
14Abnormality of T cell number (HP:0011839)4.55506159
15Stomatitis (HP:0010280)4.50272423
16Gastrointestinal infarctions (HP:0005244)4.17439867
17Mediastinal lymphadenopathy (HP:0100721)4.11708323
18Meningitis (HP:0001287)4.11084181
19Vasculitis (HP:0002633)4.08678333
20Recurrent skin infections (HP:0001581)4.06808045
21Abnormality of macrophages (HP:0004311)4.06662879
22Recurrent viral infections (HP:0004429)3.88247113
23Encephalitis (HP:0002383)3.80136898
24Keratoconjunctivitis sicca (HP:0001097)3.70687466
25Recurrent bronchitis (HP:0002837)3.66764767
26Recurrent gram-negative bacterial infections (HP:0005420)3.66751381
27Abnormality of T cells (HP:0002843)3.66404514
28Hemoptysis (HP:0002105)3.59138627
29Pulmonary infiltrates (HP:0002113)3.58322378
30Keratoconjunctivitis (HP:0001096)3.49041826
31Panhypogammaglobulinemia (HP:0003139)3.36246019
32Spontaneous hematomas (HP:0007420)3.28188152
33Obstructive lung disease (HP:0006536)3.27970865
34Chronic obstructive pulmonary disease (HP:0006510)3.27970865
35Agammaglobulinemia (HP:0004432)3.20997205
36Autoimmune hemolytic anemia (HP:0001890)3.16661678
37Gingivitis (HP:0000230)3.14576134
38Increased IgM level (HP:0003496)3.12991920
39Leukocytosis (HP:0001974)3.07838943
40Chest pain (HP:0100749)3.03141402
41Abnormality of T cell physiology (HP:0011840)3.00700743
42Chronic otitis media (HP:0000389)2.95721437
43Increased IgE level (HP:0003212)2.95687065
44Arterial thrombosis (HP:0004420)2.95243265
45IgG deficiency (HP:0004315)2.95180125
46Urticaria (HP:0001025)2.86705592
47Inflammation of the large intestine (HP:0002037)2.85022021
48Lymphopenia (HP:0001888)2.78031043
49Abnormality of B cell number (HP:0010975)2.77310464
50Gastrointestinal stroma tumor (HP:0100723)2.76959238
51Eosinophilia (HP:0001880)2.74849860
52Colitis (HP:0002583)2.74296531
53Cellulitis (HP:0100658)2.73982389
54Pustule (HP:0200039)2.73025699
55Granulocytopenia (HP:0001913)2.71992979
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.69254643
57Pulmonary embolism (HP:0002204)2.69052544
58Gastrointestinal inflammation (HP:0004386)2.65969603
59Autoimmune thrombocytopenia (HP:0001973)2.65349878
60Gingival bleeding (HP:0000225)2.63462248
61IgM deficiency (HP:0002850)2.60732177
62Peritonitis (HP:0002586)2.57585552
63Abnormality of eosinophils (HP:0001879)2.52940210
64Hypergammaglobulinemia (HP:0010702)2.52375386
65Gangrene (HP:0100758)2.52271925
66Abnormality of the pleura (HP:0002103)2.52017097
67Recurrent sinusitis (HP:0011108)2.48423192
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46304401
69Anorexia (HP:0002039)2.45304865
70Prolonged bleeding time (HP:0003010)2.45208793
71Epistaxis (HP:0000421)2.40688330
72Stomach cancer (HP:0012126)2.36005914
73Chronic diarrhea (HP:0002028)2.34897634
74Osteomyelitis (HP:0002754)2.34381560
75B lymphocytopenia (HP:0010976)2.32650932
76Hypochromic anemia (HP:0001931)2.30835637
77Recurrent pneumonia (HP:0006532)2.26390210
78Abnormality of the peritoneum (HP:0002585)2.26274491
79Hematochezia (HP:0002573)2.23652535
80IgA deficiency (HP:0002720)2.22177804
81Severe combined immunodeficiency (HP:0004430)2.20453872
82Abnormality of the endocardium (HP:0004306)2.16766147
83Sepsis (HP:0100806)2.13508388
84Cheilitis (HP:0100825)2.11859725
85Acute hepatic failure (HP:0006554)2.11745356
86Hypochromic microcytic anemia (HP:0004840)2.08359919
87Chronic sinusitis (HP:0011109)2.07634432
88Emphysema (HP:0002097)2.06994875
89Skin rash (HP:0000988)2.06345070
90Skin ulcer (HP:0200042)2.06317793
91Abnormality of the prostate (HP:0008775)2.06013675
92Restrictive lung disease (HP:0002091)2.04961543
93Bronchitis (HP:0012387)2.04921890
94Keratitis (HP:0000491)2.04343366
95Recurrent lower respiratory tract infections (HP:0002783)2.04022045
96Joint swelling (HP:0001386)2.03526416
97Episodic fever (HP:0001954)2.02687799
98Papilloma (HP:0012740)2.01484694
99Verrucae (HP:0200043)2.01484694
100Viral hepatitis (HP:0006562)2.01011265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.15633077
2MAP4K14.03597760
3TYK23.45457190
4BLK3.05813004
5TXK2.97506734
6IKBKE2.91959389
7JAK32.75162853
8IRAK42.48837840
9JAK12.44806052
10MAP3K142.39499200
11CSK2.38378598
12KIT2.36689611
13FES2.16437267
14TAOK32.14471224
15SYK2.03909345
16BTK1.98398931
17MAP3K131.96073806
18TBK11.90805260
19ZAP701.83223234
20FGFR41.80067923
21MAP2K31.76199775
22ITK1.71932397
23TEC1.68530444
24GRK61.65655282
25PRPF4B1.62417557
26FGFR31.60132120
27HCK1.50524447
28TNK21.49940795
29ERN11.48265193
30LYN1.47023576
31BMPR21.42547500
32IKBKB1.41176565
33LCK1.41120149
34CSF1R1.37722003
35FRK1.35209996
36JAK21.32564913
37FGR1.30492804
38EPHB11.25222768
39IRAK11.23635647
40MATK1.12154315
41GRK71.07360802
42NLK1.06576895
43PIK3CG1.04139920
44MARK30.97807197
45TGFBR20.87293210
46EPHA30.84065503
47PRKCQ0.83107852
48MAP3K30.81609627
49SIK30.78385551
50CAMKK20.78137144
51MAP3K10.76609602
52CDC42BPA0.76392435
53MAPK70.75412583
54PTK2B0.73931617
55STK100.72764557
56SIK20.71592918
57HIPK20.70423617
58PDK10.70389986
59MAPK110.67864718
60ACVR1B0.67687618
61PIM10.67463273
62MAP3K110.64988682
63CHUK0.61355603
64NEK90.61290809
65MAP3K70.61204760
66TRPM70.58642489
67YES10.58218521
68ADRBK20.57502967
69MARK20.53755437
70MAP2K60.52903554
71TAOK10.52258397
72FYN0.51653781
73MAPK120.51164487
74MAP3K60.49018584
75IRAK20.48969834
76CDK190.46339726
77PRKD20.46047949
78KSR20.45509431
79SGK20.42466916
80MAP3K50.41967312
81CAMKK10.40682729
82PDPK10.38529887
83STK110.37275687
84ABL10.35146132
85CDK40.33452079
86MELK0.32530361
87PRKCH0.32367635
88WNK10.32357822
89TAOK20.32113950
90EGFR0.31894445
91SGK30.31714383
92LRRK20.30845882
93STK240.30240888
94PTK60.27865315
95CDK60.27608785
96MAPKAPK20.26552408
97PDGFRB0.26214490
98MOS0.26054605
99RPS6KA60.25923624
100MAP3K20.25264922

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.33364446
2Graft-versus-host disease_Homo sapiens_hsa053323.20655123
3Autoimmune thyroid disease_Homo sapiens_hsa053203.12938755
4Primary immunodeficiency_Homo sapiens_hsa053402.96610110
5Leishmaniasis_Homo sapiens_hsa051402.89339338
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.68114172
7Staphylococcus aureus infection_Homo sapiens_hsa051502.68042584
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.64760899
9Osteoclast differentiation_Homo sapiens_hsa043802.46503456
10Asthma_Homo sapiens_hsa053102.45412780
11Type I diabetes mellitus_Homo sapiens_hsa049402.44351017
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22015647
13Measles_Homo sapiens_hsa051622.21465288
14B cell receptor signaling pathway_Homo sapiens_hsa046622.19899530
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.13358620
16Antigen processing and presentation_Homo sapiens_hsa046122.09292658
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07394651
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05748189
19Influenza A_Homo sapiens_hsa051641.90982883
20Tuberculosis_Homo sapiens_hsa051521.89403798
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82499020
22T cell receptor signaling pathway_Homo sapiens_hsa046601.77842750
23Hematopoietic cell lineage_Homo sapiens_hsa046401.76618558
24Viral myocarditis_Homo sapiens_hsa054161.75121601
25Herpes simplex infection_Homo sapiens_hsa051681.73227570
26Toxoplasmosis_Homo sapiens_hsa051451.65461464
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57192080
28Malaria_Homo sapiens_hsa051441.52998962
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.51841003
30Chemokine signaling pathway_Homo sapiens_hsa040621.42158027
31TNF signaling pathway_Homo sapiens_hsa046681.41604930
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38709662
33Rheumatoid arthritis_Homo sapiens_hsa053231.34457989
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33953156
35Hepatitis C_Homo sapiens_hsa051601.30036417
36African trypanosomiasis_Homo sapiens_hsa051431.23438004
37Hepatitis B_Homo sapiens_hsa051611.19328872
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16508857
39Acute myeloid leukemia_Homo sapiens_hsa052211.14984213
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14619768
41Legionellosis_Homo sapiens_hsa051341.14218577
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04455731
43Pertussis_Homo sapiens_hsa051331.03774673
44Phagosome_Homo sapiens_hsa041451.01247670
45Platelet activation_Homo sapiens_hsa046110.96050242
46Apoptosis_Homo sapiens_hsa042100.83471309
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.81504860
48Prolactin signaling pathway_Homo sapiens_hsa049170.80915078
49Other glycan degradation_Homo sapiens_hsa005110.79158832
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72389421
51Dorso-ventral axis formation_Homo sapiens_hsa043200.70774991
52Epstein-Barr virus infection_Homo sapiens_hsa051690.70704819
53Non-small cell lung cancer_Homo sapiens_hsa052230.68226237
54Pancreatic cancer_Homo sapiens_hsa052120.67783255
55VEGF signaling pathway_Homo sapiens_hsa043700.63880740
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62069307
57Salmonella infection_Homo sapiens_hsa051320.60382897
58Shigellosis_Homo sapiens_hsa051310.56642860
59HTLV-I infection_Homo sapiens_hsa051660.55785657
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55016249
61Lysosome_Homo sapiens_hsa041420.53115221
62FoxO signaling pathway_Homo sapiens_hsa040680.52376306
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.52288147
64Viral carcinogenesis_Homo sapiens_hsa052030.51234426
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.48743449
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.48009388
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47709145
68Chronic myeloid leukemia_Homo sapiens_hsa052200.47032054
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45191838
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43253140
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42262668
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.41943172
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41840569
74MAPK signaling pathway_Homo sapiens_hsa040100.38509254
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37062596
76Insulin resistance_Homo sapiens_hsa049310.36461022
77Systemic lupus erythematosus_Homo sapiens_hsa053220.35486473
78Amoebiasis_Homo sapiens_hsa051460.35380364
79Renal cell carcinoma_Homo sapiens_hsa052110.35295738
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34973238
81Endocytosis_Homo sapiens_hsa041440.33887606
82Choline metabolism in cancer_Homo sapiens_hsa052310.32469050
83Regulation of autophagy_Homo sapiens_hsa041400.32118657
84GnRH signaling pathway_Homo sapiens_hsa049120.31335698
85mTOR signaling pathway_Homo sapiens_hsa041500.29699781
86Type II diabetes mellitus_Homo sapiens_hsa049300.29058166
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28663917
88Notch signaling pathway_Homo sapiens_hsa043300.26710440
89Inositol phosphate metabolism_Homo sapiens_hsa005620.26621539
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26163646
91HIF-1 signaling pathway_Homo sapiens_hsa040660.25528839
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25365247
93ABC transporters_Homo sapiens_hsa020100.24659833
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.24006625
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23506064
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.23113657
97Arachidonic acid metabolism_Homo sapiens_hsa005900.20027963
98Ras signaling pathway_Homo sapiens_hsa040140.18665565
99Prostate cancer_Homo sapiens_hsa052150.18525192
100Linoleic acid metabolism_Homo sapiens_hsa005910.18198582

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