TRIM23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.23637942
2regulation of synaptic vesicle exocytosis (GO:2000300)5.15969168
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99886903
4synaptic vesicle exocytosis (GO:0016079)4.84888292
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66704008
6regulation of synaptic vesicle transport (GO:1902803)4.61056727
7vocalization behavior (GO:0071625)4.54371252
8neurotransmitter-gated ion channel clustering (GO:0072578)4.51556342
9pyrimidine nucleobase catabolic process (GO:0006208)4.43522276
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.43381836
11glutamate secretion (GO:0014047)4.43351677
12locomotory exploration behavior (GO:0035641)4.41993778
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.30085303
14protein localization to synapse (GO:0035418)4.29857382
15regulation of glutamate receptor signaling pathway (GO:1900449)4.26361430
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.17807402
17presynaptic membrane assembly (GO:0097105)4.16096582
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.13768170
19regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94029259
20postsynaptic membrane organization (GO:0001941)3.93401558
21nucleobase catabolic process (GO:0046113)3.92356160
22synaptic vesicle maturation (GO:0016188)3.89569653
23synaptic transmission, glutamatergic (GO:0035249)3.81332286
24neuronal action potential propagation (GO:0019227)3.80112022
25cellular potassium ion homeostasis (GO:0030007)3.80055666
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.79555525
27neuron-neuron synaptic transmission (GO:0007270)3.79516434
28presynaptic membrane organization (GO:0097090)3.79295708
29regulation of neuronal synaptic plasticity (GO:0048168)3.78352565
30neuron recognition (GO:0008038)3.77707391
31neurotransmitter secretion (GO:0007269)3.76558570
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64837738
33long-term synaptic potentiation (GO:0060291)3.63991935
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.62452702
35detection of calcium ion (GO:0005513)3.60707420
36glutamate receptor signaling pathway (GO:0007215)3.56266983
37inositol phosphate catabolic process (GO:0071545)3.52070725
38axonal fasciculation (GO:0007413)3.51841433
39exploration behavior (GO:0035640)3.45316310
40transmission of nerve impulse (GO:0019226)3.44035608
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37477819
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33300996
43regulation of dendritic spine development (GO:0060998)3.25132272
44proline transport (GO:0015824)3.24369161
45regulation of synaptic plasticity (GO:0048167)3.23449322
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.21525542
47negative regulation of neurotransmitter transport (GO:0051589)3.20394849
48sodium ion export (GO:0071436)3.20295593
49dendritic spine morphogenesis (GO:0060997)3.19955635
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19698214
51regulation of postsynaptic membrane potential (GO:0060078)3.19170187
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17672558
53positive regulation of synapse maturation (GO:0090129)3.16005996
54regulation of synapse structural plasticity (GO:0051823)3.13524081
55activation of protein kinase A activity (GO:0034199)3.13456564
56positive regulation of membrane potential (GO:0045838)3.13397206
57regulation of neurotransmitter secretion (GO:0046928)3.13367242
58potassium ion import (GO:0010107)3.13270029
59regulation of synapse assembly (GO:0051963)3.12153119
60neurotransmitter transport (GO:0006836)3.11154530
61cerebellar granule cell differentiation (GO:0021707)3.09465395
62long-term memory (GO:0007616)3.09174539
63neurotransmitter uptake (GO:0001504)3.09062679
64regulation of vesicle fusion (GO:0031338)3.08270453
65mechanosensory behavior (GO:0007638)3.08221803
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07109516
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02221516
68serotonin metabolic process (GO:0042428)3.01882206
69fear response (GO:0042596)3.00951749
70gamma-aminobutyric acid transport (GO:0015812)3.00043512
71behavioral defense response (GO:0002209)2.99335179
72behavioral fear response (GO:0001662)2.99335179
73layer formation in cerebral cortex (GO:0021819)2.98703033
74auditory behavior (GO:0031223)2.98566066
75innervation (GO:0060384)2.97675419
76inositol phosphate dephosphorylation (GO:0046855)2.96542189
77phosphorylated carbohydrate dephosphorylation (GO:0046838)2.96542189
78regulation of voltage-gated calcium channel activity (GO:1901385)2.94963497
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94496170
80synaptic vesicle endocytosis (GO:0048488)2.93659573
81positive regulation of neurotransmitter transport (GO:0051590)2.93254871
82regulation of synaptic transmission, GABAergic (GO:0032228)2.93147864
83synapse assembly (GO:0007416)2.91861435
84regulation of dendritic spine morphogenesis (GO:0061001)2.91630333
85glycosphingolipid biosynthetic process (GO:0006688)2.91127110
86regulation of neurotransmitter transport (GO:0051588)2.90510474
87regulation of synapse maturation (GO:0090128)2.90481517
88central nervous system projection neuron axonogenesis (GO:0021952)2.90359510
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90215065
90dendrite development (GO:0016358)2.88940261
91regulation of cell communication by electrical coupling (GO:0010649)2.88556079
92positive regulation of synapse assembly (GO:0051965)2.87797122
93striatum development (GO:0021756)2.87687532
94neuronal ion channel clustering (GO:0045161)2.86565546
95adult walking behavior (GO:0007628)2.84797899
96startle response (GO:0001964)2.84731750
97regulation of female receptivity (GO:0045924)2.84192874
98learning (GO:0007612)2.84103677
99central nervous system myelination (GO:0022010)2.84002453
100axon ensheathment in central nervous system (GO:0032291)2.84002453
101regulation of synapse organization (GO:0050807)2.83397751
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82263627
103regulation of neurotransmitter levels (GO:0001505)2.81630985
104negative regulation of neurotransmitter secretion (GO:0046929)2.81196039
105neurofilament cytoskeleton organization (GO:0060052)2.80950375
106cerebellar Purkinje cell differentiation (GO:0021702)2.75787816
107synaptic transmission (GO:0007268)2.75729074
108response to histamine (GO:0034776)2.74858300
109membrane depolarization (GO:0051899)2.74069512
110regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73803513
111positive regulation of dendritic spine development (GO:0060999)2.72802563
112positive regulation of synaptic transmission (GO:0050806)2.70797597
113acidic amino acid transport (GO:0015800)2.69926514
114regulation of synaptic transmission (GO:0050804)2.69841521
115cerebral cortex radially oriented cell migration (GO:0021799)2.68790499
116response to auditory stimulus (GO:0010996)2.68578120
117neuromuscular synaptic transmission (GO:0007274)2.67357012
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.67118562
119righting reflex (GO:0060013)2.66735916
120cell differentiation in hindbrain (GO:0021533)2.66536742
121behavioral response to cocaine (GO:0048148)2.66430914
122cellular sodium ion homeostasis (GO:0006883)2.66288002
123C4-dicarboxylate transport (GO:0015740)2.66116562
124synapse organization (GO:0050808)2.65830055
125female mating behavior (GO:0060180)2.65419641
126regulation of glutamate secretion (GO:0014048)2.65076439
127membrane depolarization during action potential (GO:0086010)2.64615937
128positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63457375
129positive regulation of neurotransmitter secretion (GO:0001956)2.62301750
130regulation of calcium ion-dependent exocytosis (GO:0017158)2.60631021
131dendrite morphogenesis (GO:0048813)2.58376899
132establishment of synaptic vesicle localization (GO:0097480)2.58269584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15417653
2GBX2_23144817_ChIP-Seq_PC3_Human4.38688339
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49783800
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41833355
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32036654
6REST_21632747_ChIP-Seq_MESCs_Mouse2.20691439
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19831739
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18650494
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18186556
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14525079
11TAF15_26573619_Chip-Seq_HEK293_Human2.12594491
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12428750
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12283131
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11338246
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05344047
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00510129
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.99586743
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97690343
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95218028
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95218028
21AR_21572438_ChIP-Seq_LNCaP_Human1.95107987
22SMAD4_21799915_ChIP-Seq_A2780_Human1.94444444
23P300_19829295_ChIP-Seq_ESCs_Human1.93285703
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.91098066
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88542125
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87888373
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87682451
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86955280
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84877778
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83692052
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83662918
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.83505217
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82220287
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81937666
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.80083553
36FUS_26573619_Chip-Seq_HEK293_Human1.77979162
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.77639736
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77503476
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76944715
40DROSHA_22980978_ChIP-Seq_HELA_Human1.73849996
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73237154
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73125529
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.69066074
44IGF1R_20145208_ChIP-Seq_DFB_Human1.68787167
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67481602
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65308742
47ZNF274_21170338_ChIP-Seq_K562_Hela1.63455892
48STAT3_23295773_ChIP-Seq_U87_Human1.59542766
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.59359740
50AR_25329375_ChIP-Seq_VCAP_Human1.59158895
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56759218
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56398954
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.56084598
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52660975
55ER_23166858_ChIP-Seq_MCF-7_Human1.51041204
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.49471983
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.49187816
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48542879
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47448737
60TCF4_23295773_ChIP-Seq_U87_Human1.47197836
61RNF2_27304074_Chip-Seq_NSC_Mouse1.41968482
62VDR_22108803_ChIP-Seq_LS180_Human1.41227911
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.39013587
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.34696950
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33767830
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.32073440
67EWS_26573619_Chip-Seq_HEK293_Human1.30582421
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30451367
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30428760
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.28948015
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28365776
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25600309
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24923951
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24923951
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24587565
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23587515
77* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21923841
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.21473697
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.21304053
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20766461
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20733384
82CBP_20019798_ChIP-Seq_JUKART_Human1.20389959
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20389959
84RUNX2_22187159_ChIP-Seq_PCA_Human1.20310744
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18111182
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16705426
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15450410
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15450410
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15402477
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.15036885
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14584064
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14039222
93AR_19668381_ChIP-Seq_PC3_Human1.13929235
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13727980
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13571525
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13168186
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12928177
98TP53_18474530_ChIP-ChIP_U2OS_Human1.11839421
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11576759
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11001744
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10947905
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10226703
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.09666187
104TP53_16413492_ChIP-PET_HCT116_Human1.09390086
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.08739197
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07622183
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06246059
108P53_22387025_ChIP-Seq_ESCs_Mouse1.04982576
109JUN_21703547_ChIP-Seq_K562_Human1.04403400
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.04354964
111BCAT_22108803_ChIP-Seq_LS180_Human1.04252323
112SOX9_26525672_Chip-Seq_HEART_Mouse1.03675149
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03255655
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02774363
115AHR_22903824_ChIP-Seq_MCF-7_Human1.01314046
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.01226354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.34089302
2MP0004859_abnormal_synaptic_plasticity4.69527229
3MP0000569_abnormal_digit_pigmentation3.65903556
4MP0003635_abnormal_synaptic_transmissio3.53824949
5MP0004270_analgesia3.33889078
6MP0009745_abnormal_behavioral_response2.97758229
7MP0002063_abnormal_learning/memory/cond2.93820992
8MP0002064_seizures2.80580475
9MP0009046_muscle_twitch2.72991141
10MP0009780_abnormal_chondrocyte_physiolo2.50593990
11MP0002572_abnormal_emotion/affect_behav2.49885538
12MP0002272_abnormal_nervous_system2.45946799
13MP0005646_abnormal_pituitary_gland2.37326245
14MP0002734_abnormal_mechanical_nocicepti2.36608786
15MP0001968_abnormal_touch/_nociception2.36220531
16MP0001486_abnormal_startle_reflex2.18014720
17MP0003787_abnormal_imprinting2.16975520
18MP0006276_abnormal_autonomic_nervous2.13805754
19MP0001188_hyperpigmentation2.10329113
20MP0005645_abnormal_hypothalamus_physiol2.10301384
21MP0005423_abnormal_somatic_nervous2.02523830
22MP0001440_abnormal_grooming_behavior2.00165291
23MP0001529_abnormal_vocalization1.97766040
24MP0000778_abnormal_nervous_system1.97755251
25MP0001501_abnormal_sleep_pattern1.96701920
26MP0002067_abnormal_sensory_capabilities1.91692670
27MP0002822_catalepsy1.90679916
28MP0001984_abnormal_olfaction1.90604899
29MP0002735_abnormal_chemical_nociception1.89276749
30MP0002736_abnormal_nociception_after1.87265436
31MP0004885_abnormal_endolymph1.85104077
32MP0003122_maternal_imprinting1.79973666
33MP0000013_abnormal_adipose_tissue1.73516480
34MP0004924_abnormal_behavior1.67686492
35MP0005386_behavior/neurological_phenoty1.67686492
36MP0002876_abnormal_thyroid_physiology1.67629912
37MP0002184_abnormal_innervation1.66908433
38MP0002733_abnormal_thermal_nociception1.66002996
39MP0002557_abnormal_social/conspecific_i1.65799161
40MP0005187_abnormal_penis_morphology1.63369507
41MP0001970_abnormal_pain_threshold1.60844790
42MP0002837_dystrophic_cardiac_calcinosis1.56829713
43MP0004811_abnormal_neuron_physiology1.51013038
44MP0002909_abnormal_adrenal_gland1.46693550
45MP0000955_abnormal_spinal_cord1.46071797
46MP0004043_abnormal_pH_regulation1.45535111
47MP0008569_lethality_at_weaning1.45292406
48MP0004142_abnormal_muscle_tone1.40175315
49MP0010386_abnormal_urinary_bladder1.37222077
50MP0004147_increased_porphyrin_level1.36511836
51MP0008877_abnormal_DNA_methylation1.32442090
52MP0002882_abnormal_neuron_morphology1.31197273
53MP0003329_amyloid_beta_deposits1.29445703
54MP0002066_abnormal_motor_capabilities/c1.29005266
55MP0003879_abnormal_hair_cell1.28335987
56MP0000749_muscle_degeneration1.28183291
57MP0003121_genomic_imprinting1.25597697
58MP0001905_abnormal_dopamine_level1.25046242
59MP0003633_abnormal_nervous_system1.22618304
60MP0000631_abnormal_neuroendocrine_gland1.18032283
61MP0004145_abnormal_muscle_electrophysio1.16704545
62MP0003690_abnormal_glial_cell1.08362970
63MP0003631_nervous_system_phenotype1.06450340
64MP0002152_abnormal_brain_morphology1.05651534
65MP0005248_abnormal_Harderian_gland1.03648229
66MP0002102_abnormal_ear_morphology1.01953676
67MP0001177_atelectasis1.00396190
68MP0005551_abnormal_eye_electrophysiolog0.98589532
69MP0000015_abnormal_ear_pigmentation0.98418255
70MP0005171_absent_coat_pigmentation0.97210875
71MP0005409_darkened_coat_color0.96012359
72MP0001502_abnormal_circadian_rhythm0.95542529
73MP0000566_synostosis0.94933633
74MP0003183_abnormal_peptide_metabolism0.94471261
75MP0001963_abnormal_hearing_physiology0.93858938
76MP0004134_abnormal_chest_morphology0.93594299
77MP0002229_neurodegeneration0.92307948
78MP0003283_abnormal_digestive_organ0.92154337
79MP0005499_abnormal_olfactory_system0.91538786
80MP0005394_taste/olfaction_phenotype0.91538786
81MP0001299_abnormal_eye_distance/0.90919333
82MP0003011_delayed_dark_adaptation0.90576300
83MP0002877_abnormal_melanocyte_morpholog0.89432993
84MP0002069_abnormal_eating/drinking_beha0.88573992
85MP0003632_abnormal_nervous_system0.85937716
86MP0004742_abnormal_vestibular_system0.85437668
87MP0003634_abnormal_glial_cell0.84474003
88MP0000647_abnormal_sebaceous_gland0.83490746
89MP0006072_abnormal_retinal_apoptosis0.81829179
90MP0004085_abnormal_heartbeat0.80389426
91MP0002090_abnormal_vision0.80024582
92MP0008260_abnormal_autophagy0.79840647
93MP0004858_abnormal_nervous_system0.79407709
94MP0004215_abnormal_myocardial_fiber0.75145441
95MP0002752_abnormal_somatic_nervous0.73588175
96MP0003123_paternal_imprinting0.72999328
97MP0000920_abnormal_myelination0.72901777
98MP0008872_abnormal_physiological_respon0.71950678
99MP0004130_abnormal_muscle_cell0.71254069
100MP0004484_altered_response_of0.70317198
101MP0005535_abnormal_body_temperature0.68442892
102MP0005620_abnormal_muscle_contractility0.67988196
103MP0000516_abnormal_urinary_system0.66301181
104MP0005367_renal/urinary_system_phenotyp0.66301181
105MP0008995_early_reproductive_senescence0.65924432
106MP0002234_abnormal_pharynx_morphology0.65102408
107MP0002160_abnormal_reproductive_system0.63840888
108MP0000751_myopathy0.63478178
109MP0002638_abnormal_pupillary_reflex0.63123865
110MP0001943_abnormal_respiration0.62756895
111MP0003137_abnormal_impulse_conducting0.62699721
112MP0002928_abnormal_bile_duct0.62523674
113MP0001664_abnormal_digestion0.60813480
114MP0003861_abnormal_nervous_system0.60765710
115MP0003698_abnormal_male_reproductive0.59329082
116MP0000003_abnormal_adipose_tissue0.59078660
117MP0001485_abnormal_pinna_reflex0.58953047
118MP0008789_abnormal_olfactory_epithelium0.58580232
119MP0000427_abnormal_hair_cycle0.57968920
120MP0002095_abnormal_skin_pigmentation0.57413774
121MP0005253_abnormal_eye_physiology0.56579062

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.44869421
2Atonic seizures (HP:0010819)4.99433400
3Focal seizures (HP:0007359)4.74669123
4Epileptic encephalopathy (HP:0200134)4.57900083
5Febrile seizures (HP:0002373)4.47222772
6Hyperventilation (HP:0002883)4.35207237
7Myokymia (HP:0002411)4.07110305
8Progressive cerebellar ataxia (HP:0002073)3.82557929
9Visual hallucinations (HP:0002367)3.65749040
10Absence seizures (HP:0002121)3.64018175
11Broad-based gait (HP:0002136)3.47665244
12Generalized tonic-clonic seizures (HP:0002069)3.35466445
13Dialeptic seizures (HP:0011146)3.33345031
14Abnormal hair whorl (HP:0010721)3.02948464
15Truncal ataxia (HP:0002078)2.96977665
16Pheochromocytoma (HP:0002666)2.95720774
17Impaired vibration sensation in the lower limbs (HP:0002166)2.90332682
18Gait imbalance (HP:0002141)2.90151637
19Scanning speech (HP:0002168)2.89576741
20Fetal akinesia sequence (HP:0001989)2.89042834
21Gaze-evoked nystagmus (HP:0000640)2.84161635
22Drooling (HP:0002307)2.71893520
23Excessive salivation (HP:0003781)2.71893520
24Medial flaring of the eyebrow (HP:0010747)2.68629850
25Urinary bladder sphincter dysfunction (HP:0002839)2.64805937
26Hypothermia (HP:0002045)2.64459225
27Protruding tongue (HP:0010808)2.61946953
28Blue irides (HP:0000635)2.58694878
29Ankle clonus (HP:0011448)2.58371904
30Neuroendocrine neoplasm (HP:0100634)2.56138636
31Urinary urgency (HP:0000012)2.51866527
32Spastic gait (HP:0002064)2.50458867
33Congenital primary aphakia (HP:0007707)2.50012112
34Epileptiform EEG discharges (HP:0011182)2.46909920
35Poor eye contact (HP:0000817)2.45470919
36Insidious onset (HP:0003587)2.43726839
37Termporal pattern (HP:0011008)2.43726839
38Intention tremor (HP:0002080)2.42448661
39Abnormal eating behavior (HP:0100738)2.40795457
40Genetic anticipation (HP:0003743)2.40498493
41Polyphagia (HP:0002591)2.38689522
42Calf muscle hypertrophy (HP:0008981)2.37522038
43Nephrogenic diabetes insipidus (HP:0009806)2.36491279
44Abnormality of the corticospinal tract (HP:0002492)2.35471678
45Limb dystonia (HP:0002451)2.34144269
46Papilledema (HP:0001085)2.33633732
47EEG with generalized epileptiform discharges (HP:0011198)2.30310421
48Depression (HP:0000716)2.28592179
49Exercise-induced muscle cramps (HP:0003710)2.24211972
50Resting tremor (HP:0002322)2.22138871
51Absent speech (HP:0001344)2.20738794
52Anxiety (HP:0000739)2.20489362
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.19771106
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19771106
55Muscle hypertrophy of the lower extremities (HP:0008968)2.19382928
56Dysdiadochokinesis (HP:0002075)2.19332718
57Megalencephaly (HP:0001355)2.18920386
58Abnormality of salivation (HP:0100755)2.18605399
59Supranuclear gaze palsy (HP:0000605)2.16391121
60Hypsarrhythmia (HP:0002521)2.15971687
61Impaired vibratory sensation (HP:0002495)2.15855544
62Hemiplegia (HP:0002301)2.15743925
63Abnormality of the musculature of the pelvis (HP:0001469)2.13116803
64Abnormality of the hip-girdle musculature (HP:0001445)2.13116803
65Specific learning disability (HP:0001328)2.12565747
66Increased circulating renin level (HP:0000848)2.12456399
67Thyroid carcinoma (HP:0002890)2.11454300
68Abnormality of binocular vision (HP:0011514)2.11383222
69Diplopia (HP:0000651)2.11383222
70Morphological abnormality of the pyramidal tract (HP:0002062)2.10230265
71Papillary thyroid carcinoma (HP:0002895)2.10197507
72Dysmetria (HP:0001310)2.09696350
73Action tremor (HP:0002345)2.08929162
74Impaired social interactions (HP:0000735)2.08691666
75Abnormal social behavior (HP:0012433)2.08691666
76Lower limb muscle weakness (HP:0007340)2.08079279
77Abnormality of the labia minora (HP:0012880)2.03059423
78Impaired smooth pursuit (HP:0007772)2.02139475
79Genital tract atresia (HP:0001827)2.02031139
80Neoplasm of the peripheral nervous system (HP:0100007)2.01135585
81Inability to walk (HP:0002540)2.00678090
82Poor coordination (HP:0002370)1.98231217
83Postural instability (HP:0002172)1.97282071
84Split foot (HP:0001839)1.97027551
85Akinesia (HP:0002304)1.96993230
86Progressive inability to walk (HP:0002505)1.95152816
87Failure to thrive in infancy (HP:0001531)1.94535277
88Difficulty running (HP:0009046)1.93721683
89Amblyopia (HP:0000646)1.93254987
90Poor speech (HP:0002465)1.93123409
91Stereotypic behavior (HP:0000733)1.91267276
92Vaginal atresia (HP:0000148)1.88475956
93Generalized hypopigmentation of hair (HP:0011358)1.87541684
94Inappropriate behavior (HP:0000719)1.84930214
95Neurofibrillary tangles (HP:0002185)1.84760497
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83478061
97Hemiparesis (HP:0001269)1.80964469
98Agitation (HP:0000713)1.80834344
99Bradykinesia (HP:0002067)1.80411420
100Fair hair (HP:0002286)1.78345025
101Dyskinesia (HP:0100660)1.77529281
102Spastic tetraplegia (HP:0002510)1.77361686
103Cerebral inclusion bodies (HP:0100314)1.76687377
104Widely spaced teeth (HP:0000687)1.76097248
105Abnormality of the calf musculature (HP:0001430)1.75874325
106Frequent falls (HP:0002359)1.75224595
107Status epilepticus (HP:0002133)1.73574694
108Gait ataxia (HP:0002066)1.72709482
109Central scotoma (HP:0000603)1.72526370
110Paraplegia (HP:0010550)1.71162036
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70830896
112Decreased circulating renin level (HP:0003351)1.69927795
113Abnormality of the lower motor neuron (HP:0002366)1.69804265
114Abnormality of ocular smooth pursuit (HP:0000617)1.68964865
115Lower limb amyotrophy (HP:0007210)1.68905999
116Nemaline bodies (HP:0003798)1.68139614
117Abnormality of the ischium (HP:0003174)1.67020118
118Torticollis (HP:0000473)1.66472773
119Retinal dysplasia (HP:0007973)1.66459991
120Amyotrophic lateral sclerosis (HP:0007354)1.64681912
121Clonus (HP:0002169)1.63846440
122Thickened helices (HP:0000391)1.62276251
123Aqueductal stenosis (HP:0002410)1.61325843
124Optic nerve hypoplasia (HP:0000609)1.60863372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.95647083
2NTRK33.92391842
3EPHA43.53247977
4MARK12.93045897
5MAP3K42.92234949
6MAP2K72.84353441
7TNIK2.34583297
8PRPF4B2.33633032
9AKT32.33055201
10ERBB32.18929107
11MINK12.17926172
12PLK22.15462292
13MAP3K122.08761308
14KSR11.84350156
15MAP3K91.81827497
16MAP2K41.76846432
17CDK191.59748148
18OBSCN1.57685724
19MAP3K21.57611366
20PAK61.57400550
21DAPK21.55334395
22MAPK131.48153937
23CAMKK21.48014714
24SGK2231.43333280
25SGK4941.43333280
26NTRK21.42546951
27INSRR1.41822429
28NTRK11.39929629
29OXSR11.39021562
30BRSK21.38018914
31BMPR21.37492823
32KSR21.35121496
33SGK21.34068405
34UHMK11.31253829
35CDK51.24470462
36PNCK1.21326502
37BCR1.18396356
38CCNB11.17381102
39WNK31.13878662
40TRIM281.12620591
41CAMKK11.04958914
42LATS11.01950762
43PAK31.00103096
44RIPK40.99109121
45CAMK1G0.97345132
46GRK50.95419052
47PRKCG0.95227910
48MAP4K20.94775139
49FGFR20.93711219
50SGK30.93705868
51CAMK2A0.93697843
52DAPK10.92554713
53PRKD30.91612108
54PHKG20.90508395
55PHKG10.90508395
56SCYL20.90067300
57NEK60.89427686
58SIK30.88562225
59CAMK40.88270658
60CDK180.85839309
61DYRK1A0.85065629
62EIF2AK30.80961631
63LATS20.80853549
64BMPR1B0.80744654
65SGK10.78570309
66DYRK30.77825179
67CSNK1G10.77618905
68CDK150.77561124
69CDK140.76121965
70WNK40.75570288
71PDK40.75429048
72PDK30.75429048
73STK390.74352342
74NEK10.74225122
75CSNK1G20.73723186
76CAMK2B0.71081391
77MKNK20.70912566
78PRKCE0.70751965
79STK38L0.68869029
80PKN10.68618658
81CAMK10.66480116
82CDK11A0.64343050
83YES10.63086276
84WEE10.61134166
85PLK30.59048725
86RPS6KB10.57750329
87RET0.57425065
88PTK2B0.56871288
89FRK0.54225979
90WNK10.53905894
91IRAK20.53447644
92BRAF0.51743441
93TAF10.51297235
94EPHA30.50143849
95PINK10.49966754
96TSSK60.49665385
97CAMK1D0.46704110
98ADRBK10.46247950
99PRKCH0.46082465
100ARAF0.45967490
101RPS6KA30.43910880
102RAF10.43748578
103CSNK1D0.43638071
104NEK90.43158722
105CSNK1G30.42155987
106SIK20.42051146
107CSNK1A1L0.41467844
108MAP3K50.40328328
109TNK20.39932428
110BRD40.39363384
111STK110.39063374
112DYRK1B0.38947204
113NUAK10.38247784
114MAPK100.37748538
115RPS6KA20.37277057
116CAMK2D0.35429419
117MAP3K10.34102968
118DYRK20.33779261
119PRKG10.33118010
120BRSK10.32526919
121MAP2K10.32418993
122CAMK2G0.32371957
123PRKACB0.31670113
124CDK30.29442157
125STK380.28965327

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93158292
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21770156
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87517297
4GABAergic synapse_Homo sapiens_hsa047272.76869816
5Long-term potentiation_Homo sapiens_hsa047202.76057227
6Olfactory transduction_Homo sapiens_hsa047402.72412784
7Circadian entrainment_Homo sapiens_hsa047132.63663311
8Morphine addiction_Homo sapiens_hsa050322.60507564
9Glutamatergic synapse_Homo sapiens_hsa047242.41947859
10Amphetamine addiction_Homo sapiens_hsa050312.34770912
11Collecting duct acid secretion_Homo sapiens_hsa049662.15658777
12Taste transduction_Homo sapiens_hsa047422.11422950
13Dopaminergic synapse_Homo sapiens_hsa047282.08969871
14Insulin secretion_Homo sapiens_hsa049112.02186578
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93098543
16Serotonergic synapse_Homo sapiens_hsa047261.85966653
17Cholinergic synapse_Homo sapiens_hsa047251.68546735
18Salivary secretion_Homo sapiens_hsa049701.68199792
19Vibrio cholerae infection_Homo sapiens_hsa051101.64144829
20Long-term depression_Homo sapiens_hsa047301.57412180
21Gastric acid secretion_Homo sapiens_hsa049711.49128957
22Cocaine addiction_Homo sapiens_hsa050301.48478408
23Oxytocin signaling pathway_Homo sapiens_hsa049211.47695205
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47655397
25Renin secretion_Homo sapiens_hsa049241.47525014
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46317381
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39915205
28Calcium signaling pathway_Homo sapiens_hsa040201.38936157
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33073414
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30929931
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25882359
32Gap junction_Homo sapiens_hsa045401.25724792
33Phototransduction_Homo sapiens_hsa047441.24514478
34Dorso-ventral axis formation_Homo sapiens_hsa043201.12902394
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11967823
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11407049
37Axon guidance_Homo sapiens_hsa043601.11224624
38Vitamin B6 metabolism_Homo sapiens_hsa007501.11094020
39cAMP signaling pathway_Homo sapiens_hsa040241.09591698
40Type II diabetes mellitus_Homo sapiens_hsa049301.08616606
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06545102
42GnRH signaling pathway_Homo sapiens_hsa049121.06348092
43Oocyte meiosis_Homo sapiens_hsa041141.05725645
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03354803
45Melanogenesis_Homo sapiens_hsa049161.03161978
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02890647
47ErbB signaling pathway_Homo sapiens_hsa040121.00204469
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95128784
49Butanoate metabolism_Homo sapiens_hsa006500.93843527
50Estrogen signaling pathway_Homo sapiens_hsa049150.93016486
51Protein export_Homo sapiens_hsa030600.92735457
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89940680
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89865959
54Alcoholism_Homo sapiens_hsa050340.89790938
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.84154480
56Glioma_Homo sapiens_hsa052140.82173792
57Propanoate metabolism_Homo sapiens_hsa006400.80350611
58Cardiac muscle contraction_Homo sapiens_hsa042600.77779867
59Circadian rhythm_Homo sapiens_hsa047100.75710983
60Type I diabetes mellitus_Homo sapiens_hsa049400.74414746
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73215369
62Regulation of autophagy_Homo sapiens_hsa041400.70777178
63Glucagon signaling pathway_Homo sapiens_hsa049220.70274056
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67572556
65beta-Alanine metabolism_Homo sapiens_hsa004100.67212058
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65625593
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.65442779
68Thyroid hormone synthesis_Homo sapiens_hsa049180.65006305
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63608728
70MAPK signaling pathway_Homo sapiens_hsa040100.63006831
71Oxidative phosphorylation_Homo sapiens_hsa001900.62723116
72Alzheimers disease_Homo sapiens_hsa050100.61802918
73Hedgehog signaling pathway_Homo sapiens_hsa043400.60245745
74Dilated cardiomyopathy_Homo sapiens_hsa054140.60094200
75Choline metabolism in cancer_Homo sapiens_hsa052310.60086285
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59249955
77Ras signaling pathway_Homo sapiens_hsa040140.57098385
78AMPK signaling pathway_Homo sapiens_hsa041520.56242770
79Endometrial cancer_Homo sapiens_hsa052130.55737286
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54328295
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54030358
82Fatty acid biosynthesis_Homo sapiens_hsa000610.53178543
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.52441074
84Inositol phosphate metabolism_Homo sapiens_hsa005620.52046923
85Wnt signaling pathway_Homo sapiens_hsa043100.51783039
86Hippo signaling pathway_Homo sapiens_hsa043900.50945962
87Pancreatic secretion_Homo sapiens_hsa049720.50271134
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48842650
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47833883
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47489448
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47368231
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47242145
93Phagosome_Homo sapiens_hsa041450.46776406
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43774753
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43516650
96Insulin signaling pathway_Homo sapiens_hsa049100.43488009
97Renal cell carcinoma_Homo sapiens_hsa052110.43332154
98Bile secretion_Homo sapiens_hsa049760.42782784
99Tight junction_Homo sapiens_hsa045300.42565292
100Basal transcription factors_Homo sapiens_hsa030220.41859850
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41242584
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40987230
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40713242
104Parkinsons disease_Homo sapiens_hsa050120.39271073
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.39075472
106Ovarian steroidogenesis_Homo sapiens_hsa049130.38122030
107Rap1 signaling pathway_Homo sapiens_hsa040150.36010028
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35478889
109Rheumatoid arthritis_Homo sapiens_hsa053230.35364758
110mTOR signaling pathway_Homo sapiens_hsa041500.34313056
111Endocytosis_Homo sapiens_hsa041440.34200949
112Colorectal cancer_Homo sapiens_hsa052100.33728899
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32935420
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32122203
115Huntingtons disease_Homo sapiens_hsa050160.30997181
116FoxO signaling pathway_Homo sapiens_hsa040680.29886616

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