TRIM24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.08053286
2piRNA metabolic process (GO:0034587)5.05196316
3microtubule depolymerization (GO:0007019)4.82240073
4nuclear pore complex assembly (GO:0051292)4.77002619
5male meiosis (GO:0007140)4.67379981
6cell wall macromolecule catabolic process (GO:0016998)4.53859527
7cell wall macromolecule metabolic process (GO:0044036)4.53859527
8nuclear pore organization (GO:0006999)4.44376991
9fusion of sperm to egg plasma membrane (GO:0007342)4.32923359
10paraxial mesoderm development (GO:0048339)4.29509104
11mitotic sister chromatid cohesion (GO:0007064)4.26153931
12synaptonemal complex assembly (GO:0007130)4.04291175
13heterochromatin organization (GO:0070828)4.01233966
14DNA methylation involved in gamete generation (GO:0043046)3.93432909
15protein K6-linked ubiquitination (GO:0085020)3.88932957
16regulation of histone H3-K9 methylation (GO:0051570)3.87775343
17multicellular organism reproduction (GO:0032504)3.85121847
18pre-miRNA processing (GO:0031054)3.82617021
19synaptonemal complex organization (GO:0070193)3.81794029
20DNA unwinding involved in DNA replication (GO:0006268)3.79484583
21DNA topological change (GO:0006265)3.79398633
22regulation of meiosis I (GO:0060631)3.64474424
23sperm-egg recognition (GO:0035036)3.64460171
24motile cilium assembly (GO:0044458)3.64207760
25epithelial cilium movement (GO:0003351)3.63669105
26axonemal dynein complex assembly (GO:0070286)3.63349413
27pore complex assembly (GO:0046931)3.63324363
28chromatin remodeling at centromere (GO:0031055)3.60944603
29acrosome assembly (GO:0001675)3.56333479
30chromosome organization involved in meiosis (GO:0070192)3.51031974
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49767043
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.49767043
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49767043
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49572119
35gene silencing by RNA (GO:0031047)3.48432115
36regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.47611171
37DNA alkylation (GO:0006305)3.44706037
38DNA methylation (GO:0006306)3.44706037
39mitotic metaphase plate congression (GO:0007080)3.41845012
40CENP-A containing nucleosome assembly (GO:0034080)3.36505066
41kinetochore organization (GO:0051383)3.36153126
42L-serine metabolic process (GO:0006563)3.34781373
43spermatid development (GO:0007286)3.32729011
44regulation of centriole replication (GO:0046599)3.32631706
45binding of sperm to zona pellucida (GO:0007339)3.32477399
46meiotic chromosome segregation (GO:0045132)3.31604103
47replicative senescence (GO:0090399)3.30563920
48regulation of RNA export from nucleus (GO:0046831)3.29487477
49sister chromatid cohesion (GO:0007062)3.29378461
50monoubiquitinated protein deubiquitination (GO:0035520)3.28085758
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.26517162
52negative regulation of histone methylation (GO:0031061)3.25079483
53meiotic nuclear division (GO:0007126)3.23989470
54histone H3-K9 methylation (GO:0051567)3.23149534
55kinetochore assembly (GO:0051382)3.23007254
56regulation of non-canonical Wnt signaling pathway (GO:2000050)3.22485918
57DNA strand renaturation (GO:0000733)3.22219308
58cell-cell recognition (GO:0009988)3.21809988
59male meiosis I (GO:0007141)3.21198687
60DNA replication-independent nucleosome assembly (GO:0006336)3.17440951
61DNA replication-independent nucleosome organization (GO:0034724)3.17440951
62regulation of sister chromatid cohesion (GO:0007063)3.17074774
63histone H2A monoubiquitination (GO:0035518)3.16794883
64regulation of posttranscriptional gene silencing (GO:0060147)3.16489458
65regulation of gene silencing by miRNA (GO:0060964)3.16489458
66regulation of gene silencing by RNA (GO:0060966)3.16489458
67nucleosome disassembly (GO:0006337)3.16306614
68protein-DNA complex disassembly (GO:0032986)3.16306614
69establishment of integrated proviral latency (GO:0075713)3.11967917
70sperm motility (GO:0030317)3.09252480
71reciprocal DNA recombination (GO:0035825)3.09098869
72reciprocal meiotic recombination (GO:0007131)3.09098869
73metaphase plate congression (GO:0051310)3.07694173
74notochord development (GO:0030903)3.05796075
75regulation of telomere maintenance via telomerase (GO:0032210)3.03900665
76ATP-dependent chromatin remodeling (GO:0043044)3.01292087
77regulation of protein polyubiquitination (GO:1902914)3.00497512
78regulation of spindle organization (GO:0090224)2.99765522
79centriole replication (GO:0007099)2.99664100
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99194677
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.99194677
82regulation of translation, ncRNA-mediated (GO:0045974)2.99194677
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.99087558
84cytoplasmic mRNA processing body assembly (GO:0033962)2.98573258
85mitotic chromosome condensation (GO:0007076)2.98572819
86DNA replication checkpoint (GO:0000076)2.98093651
87cilium movement (GO:0003341)2.97400336
88reproduction (GO:0000003)2.96961116
89positive regulation of chromosome segregation (GO:0051984)2.96741459
90plasma membrane fusion (GO:0045026)2.96340299
91intra-S DNA damage checkpoint (GO:0031573)2.94473599
92DNA methylation or demethylation (GO:0044728)2.92589179
93female gonad development (GO:0008585)2.92150535
94negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.91682953
95regulation of stem cell maintenance (GO:2000036)2.91201562
96protein localization to chromosome, centromeric region (GO:0071459)2.90016610
97histone exchange (GO:0043486)2.86693784
98meiotic cell cycle (GO:0051321)2.86606499
99negative regulation of DNA repair (GO:0045738)2.86462089
100meiotic cell cycle process (GO:1903046)2.85802704
101DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.84212205
102presynaptic membrane assembly (GO:0097105)2.83175202
103gene silencing (GO:0016458)2.83117003
104DNA strand elongation involved in DNA replication (GO:0006271)2.83097376
105sister chromatid segregation (GO:0000819)2.82357473
106histone H3-K4 methylation (GO:0051568)2.81527119
107mitotic sister chromatid segregation (GO:0000070)2.80954818
108centriole assembly (GO:0098534)2.80630043
109somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80625779
110somatic hypermutation of immunoglobulin genes (GO:0016446)2.80625779
111histone H3-K9 modification (GO:0061647)2.80473707
112regulation of chromosome segregation (GO:0051983)2.79758971
113lung-associated mesenchyme development (GO:0060484)2.79675151
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79330714
115single strand break repair (GO:0000012)2.79305721
116protein localization to kinetochore (GO:0034501)2.78248955
117regulation of helicase activity (GO:0051095)2.78002088
118mitotic G2/M transition checkpoint (GO:0044818)2.76581014
119DNA damage response, signal transduction resulting in transcription (GO:0042772)2.76354081
120histone lysine demethylation (GO:0070076)2.76135912
121histone H3-K4 trimethylation (GO:0080182)2.76116844
122DNA replication-dependent nucleosome organization (GO:0034723)2.75368910
123DNA replication-dependent nucleosome assembly (GO:0006335)2.75368910
124regulation of gene silencing (GO:0060968)2.74715060
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73793600
126regulation of centrosome cycle (GO:0046605)2.73365267
127convergent extension (GO:0060026)2.71396529
128DNA ligation (GO:0006266)2.69537742
129DNA strand elongation (GO:0022616)2.69085358
130regulation of centrosome duplication (GO:0010824)2.66745401
131chromatin assembly (GO:0031497)2.65448452
132positive regulation of SMAD protein import into nucleus (GO:0060391)2.60432209
133embryonic retina morphogenesis in camera-type eye (GO:0060059)2.59008063
134chromatin assembly or disassembly (GO:0006333)2.57633844
135regulation of DNA endoreduplication (GO:0032875)2.57295146
136non-recombinational repair (GO:0000726)2.57149716
137double-strand break repair via nonhomologous end joining (GO:0006303)2.57149716
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.56904454
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.56904454
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.56904454
141negative regulation of sister chromatid segregation (GO:0033046)2.56904454
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.56904454
143serine family amino acid biosynthetic process (GO:0009070)2.56763735
144negative regulation of chromosome segregation (GO:0051985)2.55983357
145IMP biosynthetic process (GO:0006188)2.55855533
146negative regulation of mRNA processing (GO:0050686)2.53487728
147resolution of meiotic recombination intermediates (GO:0000712)2.52949686
148DNA duplex unwinding (GO:0032508)2.52008037
149replication fork processing (GO:0031297)2.51940869
150DNA geometric change (GO:0032392)2.51236235
151spindle checkpoint (GO:0031577)2.50144132
152dorsal/ventral axis specification (GO:0009950)2.49723169
153mitotic nuclear envelope disassembly (GO:0007077)2.49480641
154negative regulation of RNA splicing (GO:0033119)2.49218927
155glycine metabolic process (GO:0006544)2.49214835
156regulation of DNA methylation (GO:0044030)2.48249781
157DNA replication initiation (GO:0006270)2.47374367
158negative regulation of DNA recombination (GO:0045910)2.46651632
159plasma lipoprotein particle assembly (GO:0034377)2.45751757
160DNA damage response, detection of DNA damage (GO:0042769)2.44621820
161mitotic spindle checkpoint (GO:0071174)2.44264182
162pyrimidine nucleobase catabolic process (GO:0006208)2.39633128
163positive regulation of dendritic spine morphogenesis (GO:0061003)2.39533813
164negative regulation of mRNA metabolic process (GO:1903312)2.39389073
165regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.36121353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85638678
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.74734565
3* SALL1_21062744_ChIP-ChIP_HESCs_Human4.52046303
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.21469320
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.11789339
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.05125752
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01126556
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.81668982
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.81668982
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.81668982
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.75245988
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57927122
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.55922636
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.54317030
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.34961580
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.31593194
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23467681
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20767458
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.01842942
20SOX2_16153702_ChIP-ChIP_HESCs_Human1.95270844
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89627416
22SOX2_18555785_ChIP-Seq_MESCs_Mouse1.87307136
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83598216
24TCF3_18692474_ChIP-Seq_MESCs_Mouse1.80286936
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78167167
26NANOG_16153702_ChIP-ChIP_HESCs_Human1.78043175
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.78006592
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77268771
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77156182
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76979563
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75411795
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74293259
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63961250
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63467341
35ZNF274_21170338_ChIP-Seq_K562_Hela1.63344444
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62412965
37* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61905620
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60358955
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56706625
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56175136
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54398197
42IGF1R_20145208_ChIP-Seq_DFB_Human1.53650009
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53487388
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52639396
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.47283134
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46293851
47FUS_26573619_Chip-Seq_HEK293_Human1.44042628
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43669537
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42408014
50* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40222349
51EZH2_22144423_ChIP-Seq_EOC_Human1.39382232
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.38996386
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38977039
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.36080313
55AR_21909140_ChIP-Seq_LNCAP_Human1.35148399
56ELK1_19687146_ChIP-ChIP_HELA_Human1.33988665
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32140385
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30006087
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29012198
60TTF2_22483619_ChIP-Seq_HELA_Human1.28304856
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28141130
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27951768
63VDR_22108803_ChIP-Seq_LS180_Human1.27938744
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.27095773
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25661647
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25286043
67* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25088542
68* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25088542
69* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24954609
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24736330
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24185473
72* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23462201
73TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23046237
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22110052
75TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21764271
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19975413
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.19055994
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19037984
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.19008815
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18382051
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17901606
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17045433
83* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16780295
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16164662
85* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16059844
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16034388
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15173306
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15150851
89P300_19829295_ChIP-Seq_ESCs_Human1.14671813
90XRN2_22483619_ChIP-Seq_HELA_Human1.14213140
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.14043932
92* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13757430
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13558668
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13442973
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12819324
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12796133
97TAF15_26573619_Chip-Seq_HEK293_Human1.11489027
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11115294
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10272654
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10151662
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.09356853
102EWS_26573619_Chip-Seq_HEK293_Human1.08629960
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.08179926
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07813503
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.07028608
106* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06747858
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.06715300
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05490658
109* STAT3_18555785_ChIP-Seq_MESCs_Mouse1.04508681
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04094721
111P300_18555785_Chip-Seq_ESCs_Mouse1.03857870
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03035922
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02810204
114IRF1_19129219_ChIP-ChIP_H3396_Human1.01986925
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01855730
116NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01583174
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.01491916
118* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00696923
119MYC_18940864_ChIP-ChIP_HL60_Human1.00575048
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00476390
121SOX9_26525672_Chip-Seq_HEART_Mouse1.00248542
122P53_22387025_ChIP-Seq_ESCs_Mouse0.98745334
123KLF4_18555785_Chip-Seq_ESCs_Mouse0.98732908
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98485400
125* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98398629
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97407169
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.95209430
128ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95134545
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94889517
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.94368182
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94000806
132ZFX_18555785_Chip-Seq_ESCs_Mouse0.93819626
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.93616147
134E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93474496
135THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93416183
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93285668
137* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93264004
138GABP_17652178_ChIP-ChIP_JURKAT_Human0.92868832
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92097244
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.91844107
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91838181
142RNF2_27304074_Chip-Seq_NSC_Mouse0.90985791
143ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90925069
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90836233
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89848969
146FOXP3_21729870_ChIP-Seq_TREG_Human0.89434217
147GBX2_23144817_ChIP-Seq_PC3_Human0.88477560
148FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88182000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.63668336
2MP0003122_maternal_imprinting3.28951241
3MP0008877_abnormal_DNA_methylation3.18557495
4MP0010094_abnormal_chromosome_stability3.18282555
5MP0008058_abnormal_DNA_repair3.04516223
6* MP0003111_abnormal_nucleus_morphology2.86530777
7MP0005410_abnormal_fertilization2.81804057
8MP0003890_abnormal_embryonic-extraembry2.47854370
9MP0003077_abnormal_cell_cycle2.39388709
10MP0002653_abnormal_ependyma_morphology2.38626181
11MP0001929_abnormal_gametogenesis2.36224957
12MP0002210_abnormal_sex_determination2.26751314
13MP0003693_abnormal_embryo_hatching2.26132893
14MP0003787_abnormal_imprinting2.16895713
15MP0000569_abnormal_digit_pigmentation2.07950724
16MP0003698_abnormal_male_reproductive2.07749235
17MP0006292_abnormal_olfactory_placode2.04026145
18MP0000566_synostosis2.01419136
19MP0001145_abnormal_male_reproductive1.90410440
20MP0003937_abnormal_limbs/digits/tail_de1.88812705
21MP0003121_genomic_imprinting1.83464660
22MP0003941_abnormal_skin_development1.82337826
23MP0004957_abnormal_blastocyst_morpholog1.74626504
24MP0000653_abnormal_sex_gland1.74544414
25MP0002102_abnormal_ear_morphology1.71599998
26MP0005248_abnormal_Harderian_gland1.66018691
27MP0002085_abnormal_embryonic_tissue1.65422295
28MP0010030_abnormal_orbit_morphology1.65339085
29MP0002084_abnormal_developmental_patter1.62827544
30MP0001293_anophthalmia1.61129440
31MP0002249_abnormal_larynx_morphology1.59026818
32MP0001672_abnormal_embryogenesis/_devel1.54187804
33MP0005380_embryogenesis_phenotype1.54187804
34MP0005076_abnormal_cell_differentiation1.49810950
35MP0008007_abnormal_cellular_replicative1.49468206
36MP0002009_preneoplasia1.49317793
37MP0004133_heterotaxia1.45618455
38MP0000778_abnormal_nervous_system1.44044296
39MP0003718_maternal_effect1.42548532
40MP0003119_abnormal_digestive_system1.40081156
41MP0003755_abnormal_palate_morphology1.37684857
42MP0010307_abnormal_tumor_latency1.36848169
43MP0003786_premature_aging1.36550057
44MP0008995_early_reproductive_senescence1.36507277
45MP0004197_abnormal_fetal_growth/weight/1.34157694
46MP0002697_abnormal_eye_size1.33677809
47MP0003935_abnormal_craniofacial_develop1.32927618
48MP0003942_abnormal_urinary_system1.32308548
49MP0001286_abnormal_eye_development1.32226974
50MP0005499_abnormal_olfactory_system1.31968302
51MP0005394_taste/olfaction_phenotype1.31968302
52MP0000432_abnormal_head_morphology1.31746086
53MP0003984_embryonic_growth_retardation1.29592610
54MP0008932_abnormal_embryonic_tissue1.28358805
55MP0002161_abnormal_fertility/fecundity1.27189978
56MP0002088_abnormal_embryonic_growth/wei1.26982989
57MP0009703_decreased_birth_body1.26636377
58MP0000350_abnormal_cell_proliferation1.26488022
59MP0000631_abnormal_neuroendocrine_gland1.25442488
60MP0003136_yellow_coat_color1.23953600
61MP0002938_white_spotting1.23556175
62MP0001529_abnormal_vocalization1.21321976
63MP0003861_abnormal_nervous_system1.18364992
64MP0002086_abnormal_extraembryonic_tissu1.18239178
65MP0001346_abnormal_lacrimal_gland1.16905365
66MP0001299_abnormal_eye_distance/1.16651373
67MP0001730_embryonic_growth_arrest1.14670222
68MP0004264_abnormal_extraembryonic_tissu1.13521847
69MP0002233_abnormal_nose_morphology1.12617990
70MP0001119_abnormal_female_reproductive1.12464375
71MP0000462_abnormal_digestive_system1.11549207
72MP0002160_abnormal_reproductive_system1.10029950
73MP0001697_abnormal_embryo_size1.08784823
74MP0002092_abnormal_eye_morphology1.06268459
75MP0003115_abnormal_respiratory_system1.05636451
76MP0003315_abnormal_perineum_morphology1.05351966
77MP0009053_abnormal_anal_canal1.04501018
78MP0002111_abnormal_tail_morphology1.04103967
79MP0005647_abnormal_sex_gland1.03085468
80MP0000537_abnormal_urethra_morphology1.01122059
81MP0002116_abnormal_craniofacial_bone1.01067606
82MP0009250_abnormal_appendicular_skeleto0.99613984
83MP0003283_abnormal_digestive_organ0.99406246
84MP0003567_abnormal_fetal_cardiomyocyte0.99211766
85MP0005389_reproductive_system_phenotype0.98066860
86MP0010352_gastrointestinal_tract_polyps0.97789265
87MP0005670_abnormal_white_adipose0.97068906
88MP0001188_hyperpigmentation0.96586477
89MP0000049_abnormal_middle_ear0.96586285
90MP0005623_abnormal_meninges_morphology0.96258660
91MP0001915_intracranial_hemorrhage0.95949132
92MP0002751_abnormal_autonomic_nervous0.95894434
93MP0009672_abnormal_birth_weight0.92850380
94MP0009697_abnormal_copulation0.91981998
95MP0008789_abnormal_olfactory_epithelium0.91269655
96MP0002089_abnormal_postnatal_growth/wei0.90079927
97MP0005395_other_phenotype0.89153245
98MP0003950_abnormal_plasma_membrane0.88165268
99MP0003699_abnormal_female_reproductive0.87628303
100MP0002152_abnormal_brain_morphology0.87093531
101MP0002736_abnormal_nociception_after0.85536636
102MP0000428_abnormal_craniofacial_morphol0.85504512
103MP0002081_perinatal_lethality0.85438233
104MP0003943_abnormal_hepatobiliary_system0.85406445
105MP0002080_prenatal_lethality0.84741629
106MP0003385_abnormal_body_wall0.84398982
107MP0000955_abnormal_spinal_cord0.84306123
108MP0003936_abnormal_reproductive_system0.83421044
109MP0002282_abnormal_trachea_morphology0.82359489
110MP0003123_paternal_imprinting0.81196801
111MP0005377_hearing/vestibular/ear_phenot0.81139525
112MP0003878_abnormal_ear_physiology0.81139525
113MP0001177_atelectasis0.81016253
114MP0000733_abnormal_muscle_development0.80547886
115MP0002254_reproductive_system_inflammat0.78626631
116MP0002932_abnormal_joint_morphology0.78464999
117MP0002114_abnormal_axial_skeleton0.77792505
118MP0002234_abnormal_pharynx_morphology0.77502190
119MP0005365_abnormal_bile_salt0.76959986
120MP0009379_abnormal_foot_pigmentation0.76330005
121MP0002184_abnormal_innervation0.76127221
122MP0005391_vision/eye_phenotype0.75706824
123MP0002109_abnormal_limb_morphology0.75520410
124MP0003938_abnormal_ear_development0.75179920
125MP0005187_abnormal_penis_morphology0.72531499
126MP0001324_abnormal_eye_pigmentation0.70393614
127MP0001485_abnormal_pinna_reflex0.70391334
128MP0001984_abnormal_olfaction0.68257898
129MP0003195_calcinosis0.68056472

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.95121266
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.79765490
3Chromsome breakage (HP:0040012)4.65453999
4Hepatoblastoma (HP:0002884)3.89268617
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.74399425
6Absent/shortened dynein arms (HP:0200106)3.74399425
7Impulsivity (HP:0100710)3.45153948
8Colon cancer (HP:0003003)3.19434522
9Abnormality of the labia minora (HP:0012880)3.12740420
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.07714163
11Abnormal respiratory motile cilium physiology (HP:0012261)2.98589752
12Ectopic kidney (HP:0000086)2.96727285
13Cortical dysplasia (HP:0002539)2.95835436
14Abnormal lung lobation (HP:0002101)2.94655283
15Meckel diverticulum (HP:0002245)2.86896520
16Supernumerary spleens (HP:0009799)2.83939003
17Abnormality of chromosome stability (HP:0003220)2.77417776
18Duplicated collecting system (HP:0000081)2.75633262
19Abnormality of the ileum (HP:0001549)2.75344552
20Abnormality of the renal collecting system (HP:0004742)2.73761715
21Abnormal respiratory motile cilium morphology (HP:0005938)2.72390415
22Abnormal respiratory epithelium morphology (HP:0012253)2.72390415
23Abnormality of the preputium (HP:0100587)2.57229619
24Abnormality of the carotid arteries (HP:0005344)2.56600516
25Heterotopia (HP:0002282)2.51836537
26Anophthalmia (HP:0000528)2.51536578
27Diastasis recti (HP:0001540)2.51481397
28Renovascular hypertension (HP:0100817)2.46050805
29Bilateral microphthalmos (HP:0007633)2.42859903
30Abnormal ciliary motility (HP:0012262)2.42737618
31Myelomeningocele (HP:0002475)2.38535555
32Absent radius (HP:0003974)2.38464766
33Hyperglycinemia (HP:0002154)2.37385800
34Nephroblastoma (Wilms tumor) (HP:0002667)2.36013168
35Pancreatic islet-cell hyperplasia (HP:0004510)2.33937861
36Midline defect of the nose (HP:0004122)2.33605822
37Broad alveolar ridges (HP:0000187)2.32672803
38Volvulus (HP:0002580)2.30644362
39Vitreoretinal degeneration (HP:0000655)2.26958311
40Choanal stenosis (HP:0000452)2.26709741
41Abnormality of the fingertips (HP:0001211)2.26701116
42Increased nuchal translucency (HP:0010880)2.26301670
43Supernumerary ribs (HP:0005815)2.26174966
44Rectovaginal fistula (HP:0000143)2.25720551
45Rectal fistula (HP:0100590)2.25720551
46Bifid tongue (HP:0010297)2.25108322
47Absent forearm bone (HP:0003953)2.24124630
48Aplasia involving forearm bones (HP:0009822)2.24124630
49Reticulocytopenia (HP:0001896)2.22008225
50Medulloblastoma (HP:0002885)2.20332615
51Facial hemangioma (HP:0000329)2.17882727
52Lip pit (HP:0100267)2.16915781
53Vaginal fistula (HP:0004320)2.16571079
54Embryonal renal neoplasm (HP:0011794)2.15962628
55High anterior hairline (HP:0009890)2.14489728
56Ependymoma (HP:0002888)2.13951029
57Partial duplication of thumb phalanx (HP:0009944)2.13923953
58Absent septum pellucidum (HP:0001331)2.12270584
59Elfin facies (HP:0004428)2.12253070
60Embryonal neoplasm (HP:0002898)2.11570226
61Hypobetalipoproteinemia (HP:0003563)2.11344740
62Neoplasm of the oral cavity (HP:0100649)2.11202622
63Broad thumb (HP:0011304)2.10952982
64Rhinitis (HP:0012384)2.08625079
65Small intestinal stenosis (HP:0012848)2.08502106
66Duodenal stenosis (HP:0100867)2.08502106
67Rib fusion (HP:0000902)2.07515150
68Shawl scrotum (HP:0000049)2.07176692
69Abnormality of the septum pellucidum (HP:0007375)2.07127893
70Absent eyebrow (HP:0002223)2.06298432
71Supernumerary bones of the axial skeleton (HP:0009144)2.05155130
72Abnormality of the diencephalon (HP:0010662)2.05047954
73Birth length less than 3rd percentile (HP:0003561)2.04840290
74Anal stenosis (HP:0002025)2.03967657
75Rhabdomyosarcoma (HP:0002859)2.03450920
76Renal hypoplasia (HP:0000089)2.02311001
77Patellar aplasia (HP:0006443)2.02121910
78Tubulointerstitial nephritis (HP:0001970)2.01723842
79Sloping forehead (HP:0000340)2.01304612
80Cutaneous finger syndactyly (HP:0010554)2.00728055
81Triphalangeal thumb (HP:0001199)1.99258965
82Intestinal fistula (HP:0100819)1.97819656
83Cutaneous syndactyly (HP:0012725)1.97727172
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.97395738
85Facial cleft (HP:0002006)1.96634087
86Chronic bronchitis (HP:0004469)1.95665297
87Glioma (HP:0009733)1.95480712
88Maternal diabetes (HP:0009800)1.94921616
89Abnormal hair whorl (HP:0010721)1.94838015
90Hyperglycinuria (HP:0003108)1.94686549
91Abnormal spermatogenesis (HP:0008669)1.94410681
92Oligodactyly (HP:0012165)1.93514094
93Renal duplication (HP:0000075)1.93317984
94Nephronophthisis (HP:0000090)1.92932103
95Esophageal atresia (HP:0002032)1.92180327
96Abnormality of DNA repair (HP:0003254)1.90878007
97Astrocytoma (HP:0009592)1.90169068
98Abnormality of the astrocytes (HP:0100707)1.90169068
99Short thumb (HP:0009778)1.90167449
100Irregular epiphyses (HP:0010582)1.90138572
101Abnormality of the renal medulla (HP:0100957)1.90105597
102Azoospermia (HP:0000027)1.88654869
103Aplasia/Hypoplasia of the patella (HP:0006498)1.88563956
104Deep venous thrombosis (HP:0002625)1.88509350
105Broad palm (HP:0001169)1.88138081
106Trigonocephaly (HP:0000243)1.86601753
107Prolonged partial thromboplastin time (HP:0003645)1.86329119
108Oligodactyly (hands) (HP:0001180)1.85836960
109Hypoplastic labia majora (HP:0000059)1.85261909
110Abnormality of the duodenum (HP:0002246)1.85120285
111Hypoplastic ischia (HP:0003175)1.85064931
112Chronic hepatic failure (HP:0100626)1.83743282
113Preaxial foot polydactyly (HP:0001841)1.83420734
114Clubbing of toes (HP:0100760)1.81575754
115Hypochromic microcytic anemia (HP:0004840)1.80805703
116Gastrointestinal carcinoma (HP:0002672)1.79798588
117Malignant gastrointestinal tract tumors (HP:0006749)1.79798588
118Intestinal atresia (HP:0011100)1.78543781
119Absent thumb (HP:0009777)1.76830995
120Gastrointestinal atresia (HP:0002589)1.76698074
121Duplication of thumb phalanx (HP:0009942)1.76638750
122Abnormality of the ischium (HP:0003174)1.76393175
123Skull defect (HP:0001362)1.76313916
124Osteomalacia (HP:0002749)1.75324989
125Long eyelashes (HP:0000527)1.75217801
126Abnormality of serine family amino acid metabolism (HP:0010894)1.73734801
127Abnormality of glycine metabolism (HP:0010895)1.73734801
128Optic nerve hypoplasia (HP:0000609)1.72724173
129Male infertility (HP:0003251)1.72053293
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71026225
131Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70978751
132Short 4th metacarpal (HP:0010044)1.70978751
133Cupped ear (HP:0000378)1.70910193
134Omphalocele (HP:0001539)1.70423279
135Abnormality of the labia majora (HP:0012881)1.70397706
136Short humerus (HP:0005792)1.70229826
137Partial agenesis of the corpus callosum (HP:0001338)1.69933115
138Spastic diplegia (HP:0001264)1.69891163
139Partial duplication of the phalanx of hand (HP:0009999)1.69524497
140Scrotal hypoplasia (HP:0000046)1.69034631
141Abnormality of abdominal situs (HP:0011620)1.68197465
142Abdominal situs inversus (HP:0003363)1.68197465
143Flat cornea (HP:0007720)1.66877883
144Overriding aorta (HP:0002623)1.66736195
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66673628
146Acanthocytosis (HP:0001927)1.66021903
147Broad phalanges of the hand (HP:0009768)1.65104223
148Septo-optic dysplasia (HP:0100842)1.65043597
149Missing ribs (HP:0000921)1.64426790
150Abnormality of cochlea (HP:0000375)1.64235507
151Hemivertebrae (HP:0002937)1.63728428
152Abnormality of lateral ventricle (HP:0030047)1.63628888
153Aqueductal stenosis (HP:0002410)1.63534375
154Abnormality of the pubic bones (HP:0003172)1.63375938
155Obsessive-compulsive behavior (HP:0000722)1.63203879
156Abnormality of the aortic arch (HP:0012303)1.61455987
157Aplasia/hypoplasia of the humerus (HP:0006507)1.61440563
158Abnormality of the lacrimal duct (HP:0011481)1.61253091
159Postaxial foot polydactyly (HP:0001830)1.61198339
160Overlapping toe (HP:0001845)1.61187149
161Abnormality of the nasal septum (HP:0000419)1.60815605
162Anal atresia (HP:0002023)1.60411560
163Sparse scalp hair (HP:0002209)1.60396619
164Renal dysplasia (HP:0000110)1.59715805
165Abnormality of the phalanges of the hallux (HP:0010057)1.59670482
166Abnormality of the parathyroid morphology (HP:0011766)1.58238270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.72353686
2LATS13.46909468
3CDC72.97687341
4PDK42.92042238
5PDK32.92042238
6BRD42.89866165
7TNIK2.71936482
8TTK2.68771799
9STK38L2.47049105
10ZAK2.30109925
11NEK22.28293506
12PNCK2.16863094
13EPHA22.11532271
14SRPK12.10911533
15AKT32.08722395
16PDK22.07493969
17CHEK21.95614103
18TAF11.95591581
19DYRK31.89168123
20ICK1.88707887
21STK31.85066503
22CASK1.83712383
23BRSK21.83603963
24ATR1.70421792
25WEE11.56443034
26MKNK21.55712799
27PBK1.54990533
28PLK11.50722360
29CAMK1D1.48315282
30CDK71.46475784
31CHEK11.42242795
32TSSK61.41921459
33PLK41.40609492
34ATM1.39480910
35CAMK1G1.38763436
36FGFR11.33868167
37BUB11.32281997
38MAP3K41.24039571
39LATS21.23719998
40CDK91.22224251
41MTOR1.20518928
42NEK11.13245905
43PLK31.10854452
44MKNK11.10340347
45VRK21.09866294
46YES11.08420240
47MAP3K61.08218458
48INSRR1.06832599
49EIF2AK21.06443359
50NUAK11.05572668
51AURKB1.03651297
52WNK41.01968795
53FRK0.96332893
54FGFR20.95445473
55CDK60.92610469
56CDK20.92480025
57EEF2K0.91951307
58FGFR40.91395349
59MELK0.90867137
60CDK40.88069770
61STK40.86188942
62CDK10.84268740
63CDK30.79368666
64BCR0.78412619
65DYRK20.77993917
66ALK0.77938882
67GRK10.75652324
68NLK0.75301881
69ERBB40.73946815
70BRSK10.73314446
71CSNK1D0.73076155
72STK160.72688975
73EIF2AK10.71724673
74PRKAA10.71659470
75PASK0.70816082
76MARK10.69751240
77SGK20.69178250
78RPS6KB20.67971868
79CHUK0.67523516
80TYRO30.66538440
81TRIM280.66456424
82ACVR1B0.64320426
83LMTK20.64058664
84GSK3B0.62764883
85DDR20.61448675
86CSNK1E0.61029853
87STK380.60508732
88CSNK1A1L0.60144057
89MAPK140.58311894
90SMG10.58236148
91SGK4940.58080586
92SGK2230.58080586
93WNK10.57632916
94PRKAA20.57350490
95PRKDC0.56927801
96MAPK100.56808571
97NTRK20.56191880
98WNK30.55899251
99CSNK1G20.55309976
100MAP3K80.54434048
101NEK60.53419120
102FGFR30.53336729
103AKT10.52532120
104PLK20.51040535
105RPS6KA40.50815264
106AURKA0.50509715
107EPHA40.50244210
108TLK10.49683079
109ERBB20.47912727
110SGK30.47716623
111CDK190.46835375
112MAPK10.46321107
113DMPK0.44296561
114EIF2AK30.43887433
115PIM10.43817167
116PRKCG0.43378216
117STK390.42701302
118AKT20.42550413
119PRKD30.42273555
120ERBB30.42177679
121PDGFRA0.42092388
122PKN10.41823883
123PIK3CA0.41643208
124VRK10.41182702
125RPS6KB10.40013033
126FLT30.39811710
127PRKCI0.38934558
128RPS6KA50.38194006
129CSNK2A10.38166949
130MAPK80.37562283
131CSNK1G10.35387659
132CDC42BPA0.34004783
133BMPR1B0.32705860
134PDGFRB0.30709429
135MAP3K100.29407028
136CSNK2A20.28648840
137DYRK1A0.28190974

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.89540600
2mRNA surveillance pathway_Homo sapiens_hsa030152.70612097
3Basal transcription factors_Homo sapiens_hsa030222.68256197
4Homologous recombination_Homo sapiens_hsa034402.57251276
5Mismatch repair_Homo sapiens_hsa034302.55734312
6RNA transport_Homo sapiens_hsa030132.55569578
7Cell cycle_Homo sapiens_hsa041102.55424612
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53791648
9Lysine degradation_Homo sapiens_hsa003102.35544122
10Vitamin B6 metabolism_Homo sapiens_hsa007502.19890550
11Non-homologous end-joining_Homo sapiens_hsa034502.16543252
12Basal cell carcinoma_Homo sapiens_hsa052172.13345372
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10625239
14One carbon pool by folate_Homo sapiens_hsa006702.02005898
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.97893701
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.95610558
17Base excision repair_Homo sapiens_hsa034101.89576755
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85037575
19Spliceosome_Homo sapiens_hsa030401.84006149
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79559477
21RNA degradation_Homo sapiens_hsa030181.68616650
22Nucleotide excision repair_Homo sapiens_hsa034201.66434741
23Systemic lupus erythematosus_Homo sapiens_hsa053221.65611754
24Ribosome_Homo sapiens_hsa030101.63895006
25p53 signaling pathway_Homo sapiens_hsa041151.61786066
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57345848
27DNA replication_Homo sapiens_hsa030301.54743085
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52774682
29MicroRNAs in cancer_Homo sapiens_hsa052061.51305637
30Adherens junction_Homo sapiens_hsa045201.49946318
31Selenocompound metabolism_Homo sapiens_hsa004501.46160328
32Hippo signaling pathway_Homo sapiens_hsa043901.45643684
33Hedgehog signaling pathway_Homo sapiens_hsa043401.42179086
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32119221
35TGF-beta signaling pathway_Homo sapiens_hsa043501.28829412
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28058960
37RNA polymerase_Homo sapiens_hsa030201.26979672
38Fat digestion and absorption_Homo sapiens_hsa049751.26851876
39Pyruvate metabolism_Homo sapiens_hsa006201.25301330
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23332065
41Fatty acid metabolism_Homo sapiens_hsa012121.23036096
42Biosynthesis of amino acids_Homo sapiens_hsa012301.16295787
43Wnt signaling pathway_Homo sapiens_hsa043101.12130038
44Linoleic acid metabolism_Homo sapiens_hsa005911.11673129
45Retinol metabolism_Homo sapiens_hsa008301.11465965
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11165912
47Notch signaling pathway_Homo sapiens_hsa043301.06813625
48Vitamin digestion and absorption_Homo sapiens_hsa049771.05204063
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03466289
50Prostate cancer_Homo sapiens_hsa052151.02486345
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02419105
52Oocyte meiosis_Homo sapiens_hsa041141.00246986
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.00182759
54Dorso-ventral axis formation_Homo sapiens_hsa043201.00079649
55Thyroid cancer_Homo sapiens_hsa052160.98771724
56Fatty acid degradation_Homo sapiens_hsa000710.98480066
57Protein export_Homo sapiens_hsa030600.96915863
58Small cell lung cancer_Homo sapiens_hsa052220.93898019
59Butanoate metabolism_Homo sapiens_hsa006500.90578358
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89784421
61Fatty acid biosynthesis_Homo sapiens_hsa000610.88809901
62Viral carcinogenesis_Homo sapiens_hsa052030.86078510
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85610968
64Complement and coagulation cascades_Homo sapiens_hsa046100.85296427
65Pyrimidine metabolism_Homo sapiens_hsa002400.83070683
66HTLV-I infection_Homo sapiens_hsa051660.79164330
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78418750
68Circadian rhythm_Homo sapiens_hsa047100.74857935
69Carbon metabolism_Homo sapiens_hsa012000.74244487
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73724079
71Herpes simplex infection_Homo sapiens_hsa051680.73019549
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70995518
73ABC transporters_Homo sapiens_hsa020100.70884054
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69873749
75Pathways in cancer_Homo sapiens_hsa052000.68967783
76AMPK signaling pathway_Homo sapiens_hsa041520.68169590
77Purine metabolism_Homo sapiens_hsa002300.66759148
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66675974
79FoxO signaling pathway_Homo sapiens_hsa040680.66513776
80Tight junction_Homo sapiens_hsa045300.65622452
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.64546192
82Glucagon signaling pathway_Homo sapiens_hsa049220.63856037
83Inositol phosphate metabolism_Homo sapiens_hsa005620.62360483
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61855504
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59440626
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.58041878
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57069243
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57004479
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.55147012
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54845839
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.54656728
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54221481
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53440930
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53194656
95Axon guidance_Homo sapiens_hsa043600.53056604
96Endometrial cancer_Homo sapiens_hsa052130.52043251
97Ovarian steroidogenesis_Homo sapiens_hsa049130.51979915
98Melanoma_Homo sapiens_hsa052180.50922967
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50429312
100Epstein-Barr virus infection_Homo sapiens_hsa051690.48935231
101Propanoate metabolism_Homo sapiens_hsa006400.48236130
102ECM-receptor interaction_Homo sapiens_hsa045120.47848369
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47706731
104Fatty acid elongation_Homo sapiens_hsa000620.47129938
105mTOR signaling pathway_Homo sapiens_hsa041500.45525083
106Colorectal cancer_Homo sapiens_hsa052100.45442054
107Tryptophan metabolism_Homo sapiens_hsa003800.45315214
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.45168415
109Alcoholism_Homo sapiens_hsa050340.44703038
110Phototransduction_Homo sapiens_hsa047440.44565781
111Nicotine addiction_Homo sapiens_hsa050330.43799751
112Glycerolipid metabolism_Homo sapiens_hsa005610.42254051
113Thyroid hormone synthesis_Homo sapiens_hsa049180.42211341
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41311985
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.40863197
116Peroxisome_Homo sapiens_hsa041460.40404170
117Arachidonic acid metabolism_Homo sapiens_hsa005900.38992008
118Starch and sucrose metabolism_Homo sapiens_hsa005000.38768336
119Steroid biosynthesis_Homo sapiens_hsa001000.37995442
120Metabolic pathways_Homo sapiens_hsa011000.37198248
121Ether lipid metabolism_Homo sapiens_hsa005650.37037562
122Nitrogen metabolism_Homo sapiens_hsa009100.36884023
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.35960567
124Huntingtons disease_Homo sapiens_hsa050160.35506679
125Chemical carcinogenesis_Homo sapiens_hsa052040.33320826
126Arginine biosynthesis_Homo sapiens_hsa002200.32695533
127Melanogenesis_Homo sapiens_hsa049160.32138603
128Arginine and proline metabolism_Homo sapiens_hsa003300.31995400
129PPAR signaling pathway_Homo sapiens_hsa033200.31753206
130beta-Alanine metabolism_Homo sapiens_hsa004100.31739524
131Choline metabolism in cancer_Homo sapiens_hsa052310.31706584
132Protein digestion and absorption_Homo sapiens_hsa049740.30206850
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29746305
134Glutathione metabolism_Homo sapiens_hsa004800.29087560
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27513247
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27038201
137N-Glycan biosynthesis_Homo sapiens_hsa005100.24337554
138Long-term depression_Homo sapiens_hsa047300.22882661
139Taste transduction_Homo sapiens_hsa047420.22710839

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