TRIM26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.79532390
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.72309687
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72309687
4antigen processing and presentation of endogenous antigen (GO:0019883)4.66968525
5regulation of gamma-delta T cell activation (GO:0046643)3.81932458
6regulation of gamma-delta T cell differentiation (GO:0045586)3.66157434
7regulation of interleukin-12 biosynthetic process (GO:0045075)3.57617487
8positive thymic T cell selection (GO:0045059)3.55402341
9positive regulation of interferon-alpha production (GO:0032727)3.53543192
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.33590388
11regulation of interferon-alpha production (GO:0032647)3.33189807
12response to type I interferon (GO:0034340)3.31321769
13regulation of T cell tolerance induction (GO:0002664)3.27960425
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27901087
15regulation of cytokine secretion involved in immune response (GO:0002739)3.26580260
16type I interferon signaling pathway (GO:0060337)3.24091134
17cellular response to type I interferon (GO:0071357)3.24091134
18positive regulation of Cdc42 GTPase activity (GO:0043089)3.23396424
19myeloid dendritic cell differentiation (GO:0043011)3.22477467
20regulation of vitamin D biosynthetic process (GO:0060556)3.21611337
21modulation by symbiont of host defense response (GO:0052031)3.18948425
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18948425
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18948425
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.18948425
25modulation by symbiont of host immune response (GO:0052553)3.18948425
26positive regulation by symbiont of host defense response (GO:0052509)3.18948425
27positive regulation of keratinocyte differentiation (GO:0045618)3.18609788
28negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.17874283
29necroptotic process (GO:0070266)3.13308503
30negative thymic T cell selection (GO:0045060)3.06207649
31regulation of interferon-beta biosynthetic process (GO:0045357)3.04392084
32regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03723297
33UDP-N-acetylglucosamine metabolic process (GO:0006047)2.98742191
34thymic T cell selection (GO:0045061)2.94045868
35negative T cell selection (GO:0043383)2.93182709
36sphingosine metabolic process (GO:0006670)2.92923524
37melanin metabolic process (GO:0006582)2.92616503
38regulation of B cell differentiation (GO:0045577)2.92245585
39positive regulation of humoral immune response (GO:0002922)2.92054974
40regulation of T-helper 1 cell differentiation (GO:0045625)2.90274383
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.88965297
42defense response to protozoan (GO:0042832)2.87820180
43negative regulation of viral genome replication (GO:0045071)2.85835482
44I-kappaB phosphorylation (GO:0007252)2.85317265
45positive regulation of interferon-beta production (GO:0032728)2.83616480
46antigen processing and presentation via MHC class Ib (GO:0002475)2.81340627
47regulation of B cell receptor signaling pathway (GO:0050855)2.80922205
48regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76490575
49melanin biosynthetic process (GO:0042438)2.75279166
50response to protozoan (GO:0001562)2.73149579
51response to laminar fluid shear stress (GO:0034616)2.72939825
52cellular response to virus (GO:0098586)2.72375569
53germinal center formation (GO:0002467)2.72070519
54response to muramyl dipeptide (GO:0032495)2.67159274
55positive regulation of antigen processing and presentation (GO:0002579)2.66583565
56regulation of chronic inflammatory response (GO:0002676)2.66032260
57myeloid dendritic cell activation (GO:0001773)2.65801647
58regulation of podosome assembly (GO:0071801)2.65219632
59regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.63271368
60lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63264101
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61071760
62T cell selection (GO:0045058)2.60679424
63interferon-gamma production (GO:0032609)2.59434200
64regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59108704
65JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58407984
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58208424
67detection of molecule of bacterial origin (GO:0032490)2.58026053
68response to peptidoglycan (GO:0032494)2.57956884
69positive T cell selection (GO:0043368)2.55845258
70NIK/NF-kappaB signaling (GO:0038061)2.55827237
71regulation of vitamin metabolic process (GO:0030656)2.55691579
72* negative regulation of viral release from host cell (GO:1902187)2.53868356
73detection of bacterium (GO:0016045)2.52130782
74indole-containing compound catabolic process (GO:0042436)2.51273055
75indolalkylamine catabolic process (GO:0046218)2.51273055
76tryptophan catabolic process (GO:0006569)2.51273055
77negative regulation of cell killing (GO:0031342)2.50665675
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50665675
79T cell migration (GO:0072678)2.49860768
80regulation of RIG-I signaling pathway (GO:0039535)2.49180359
81B cell receptor signaling pathway (GO:0050853)2.48982277
82cellular response to interferon-alpha (GO:0035457)2.47634697
83response to interferon-alpha (GO:0035455)2.47405658
84B cell mediated immunity (GO:0019724)2.47192274
85diol metabolic process (GO:0034311)2.47057919
86macrophage activation involved in immune response (GO:0002281)2.44345569
87regulation of tolerance induction (GO:0002643)2.43799682
88T cell lineage commitment (GO:0002360)2.43628688
89positive regulation of natural killer cell differentiation (GO:0032825)2.43300710
90detection of other organism (GO:0098543)2.42819304
91leukocyte aggregation (GO:0070486)2.42174886
92cellular response to interferon-gamma (GO:0071346)2.42024336
93N-acetylneuraminate metabolic process (GO:0006054)2.41735946
94natural killer cell differentiation (GO:0001779)2.40041841
95programmed necrotic cell death (GO:0097300)2.39960197
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39792922
97regulation of interferon-beta production (GO:0032648)2.39158283
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38769599
99defense response to virus (GO:0051607)2.36938645
100positive regulation of type 2 immune response (GO:0002830)2.36683191
101positive regulation of extracellular matrix organization (GO:1903055)2.35984511
102keratinocyte development (GO:0003334)2.35793252
103positive regulation of toll-like receptor signaling pathway (GO:0034123)2.35730995
104regulation of apoptotic process involved in morphogenesis (GO:1902337)2.35464386
105regulation of cholesterol storage (GO:0010885)2.34388918
106interferon-gamma-mediated signaling pathway (GO:0060333)2.33781520
107kynurenine metabolic process (GO:0070189)2.32909343
108regulation of alpha-beta T cell proliferation (GO:0046640)2.32732724
109immunoglobulin mediated immune response (GO:0016064)2.32244353
110tryptophan metabolic process (GO:0006568)2.32045021
111negative regulation of granulocyte differentiation (GO:0030853)2.32042052
112lactate metabolic process (GO:0006089)2.31857667
113response to interferon-gamma (GO:0034341)2.31337371
114regulation of antigen processing and presentation (GO:0002577)2.31079414
115regulation of histone H3-K27 methylation (GO:0061085)2.30113926
116positive regulation of p38MAPK cascade (GO:1900745)2.29947687
117regulation of inflammatory response to antigenic stimulus (GO:0002861)2.29690218
118mammary gland epithelial cell proliferation (GO:0033598)2.29100688
119positive regulation of cholesterol efflux (GO:0010875)2.28642924
120branching involved in mammary gland duct morphogenesis (GO:0060444)2.27558872
121* negative regulation of viral process (GO:0048525)2.27420841
122positive regulation of tolerance induction (GO:0002645)2.27096215
123phospholipid efflux (GO:0033700)2.26696856
124regulation of membrane protein ectodomain proteolysis (GO:0051043)2.26547646
125regulation of interleukin-8 biosynthetic process (GO:0045414)2.26056166
126necrotic cell death (GO:0070265)2.25511522
127aromatic amino acid family catabolic process (GO:0009074)2.25074239
128tolerance induction (GO:0002507)2.25030299
129cellular response to interleukin-15 (GO:0071350)2.24729742
130negative regulation of interleukin-12 production (GO:0032695)2.24648931
131positive regulation of B cell differentiation (GO:0045579)2.24421916
132regulation of viral genome replication (GO:0045069)2.24076942
133ER overload response (GO:0006983)2.22949583
134negative regulation of bone resorption (GO:0045779)2.22685664
135response to host immune response (GO:0052572)2.21937725
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.21937725
137pinocytosis (GO:0006907)2.19035685
138regulation of defense response to virus by host (GO:0050691)2.17986556
139positive regulation of interleukin-12 production (GO:0032735)2.17616664
140positive regulation of cellular amide metabolic process (GO:0034250)2.17548088
141T cell apoptotic process (GO:0070231)2.17321746
142CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.17256646
143T-helper cell differentiation (GO:0042093)2.17256646
144positive regulation of cholesterol transport (GO:0032376)2.17206678
145positive regulation of sterol transport (GO:0032373)2.17206678
146Rap protein signal transduction (GO:0032486)2.17117121
147response to interleukin-15 (GO:0070672)2.16621161
148regulation of extracellular matrix disassembly (GO:0010715)2.16109446
149regulation of superoxide anion generation (GO:0032928)2.14977193
150regulation of cholesterol homeostasis (GO:2000188)2.14801642
151protein carboxylation (GO:0018214)2.14516957
152peptidyl-glutamic acid carboxylation (GO:0017187)2.14516957
153negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.13475756
154phospholipid homeostasis (GO:0055091)2.13180405
155detection of external biotic stimulus (GO:0098581)2.12913510
156regulation of response to interferon-gamma (GO:0060330)2.12226922
157response to host (GO:0075136)2.11032764
158response to host defenses (GO:0052200)2.11032764
159response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.11032764
160complement activation, alternative pathway (GO:0006957)2.10886476
161regulation of interleukin-12 production (GO:0032655)2.10556515
162negative regulation of cholesterol transport (GO:0032375)2.09899679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.60278071
2E2F7_22180533_ChIP-Seq_HELA_Human4.45730929
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.41829441
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.54804098
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.37489669
6* IRF8_21731497_ChIP-ChIP_J774_Mouse3.22095004
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20335008
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.05491446
9* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99152322
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89229011
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.68469727
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.68080749
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.50131996
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42542098
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.33591390
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.33012905
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28322285
18MYC_22102868_ChIP-Seq_BL_Human2.24753861
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.24304488
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19022136
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18375379
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.16306393
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12291258
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09082922
25* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01183857
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98503938
27MAF_26560356_Chip-Seq_TH1_Human1.96328889
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95196066
29RUNX_20019798_ChIP-Seq_JUKART_Human1.87311728
30MYB_26560356_Chip-Seq_TH1_Human1.82199679
31MYB_26560356_Chip-Seq_TH2_Human1.76658221
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76593161
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71565766
34VDR_21846776_ChIP-Seq_THP-1_Human1.71051563
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68757302
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68474264
37TFEB_21752829_ChIP-Seq_HELA_Human1.66226734
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62576496
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62466383
40TCF7_22412390_ChIP-Seq_EML_Mouse1.61619703
41GATA1_22025678_ChIP-Seq_K562_Human1.61618065
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60657774
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57664261
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57052411
45UTX_26944678_Chip-Seq_JUKART_Human1.55317416
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50688705
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.46074267
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45983969
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41410721
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40917608
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39629584
52CLOCK_20551151_ChIP-Seq_293T_Human1.38896546
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38556153
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36270095
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36210485
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.34874132
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33779248
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32858934
59KDM2B_26808549_Chip-Seq_DND41_Human1.30610944
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29886726
61VDR_24763502_ChIP-Seq_THP-1_Human1.29225067
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.27499916
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25487281
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.24929308
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24730354
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24730354
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24730354
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23184749
69MAF_26560356_Chip-Seq_TH2_Human1.19451652
70SPI1_23547873_ChIP-Seq_NB4_Human1.18805752
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18286063
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17173375
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16994655
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14679808
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.13376488
76PU_27001747_Chip-Seq_BMDM_Mouse1.13305110
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12797415
78SCL_19346495_ChIP-Seq_HPC-7_Human1.12280581
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.12150256
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11868243
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09975937
82* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08093941
83* SPI1_23127762_ChIP-Seq_K562_Human1.05657039
84* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05325816
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04840889
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04010142
87GATA3_27048872_Chip-Seq_THYMUS_Human1.03618250
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.02573009
89GATA6_25053715_ChIP-Seq_YYC3_Human1.01722739
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00347205
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99859537
92RACK7_27058665_Chip-Seq_MCF-7_Human0.99095975
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98706893
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98254473
95NCOR1_26117541_ChIP-Seq_K562_Human0.98108061
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97825417
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96374091
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96029421
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.95638259
100LXR_22292898_ChIP-Seq_THP-1_Human0.95350850
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94600791
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93954263
103ATF3_27146783_Chip-Seq_COLON_Human0.93359905
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92333819
105* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92172907
106* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92172907
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92104059
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91875040
109* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91815849
110* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91438699
111* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90692937
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90114051
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89604185
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89600595
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88818874
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88624428
117PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86837131
118GATA4_25053715_ChIP-Seq_YYC3_Human0.85441395
119VDR_24787735_ChIP-Seq_THP-1_Human0.85176293
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84254660
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.81708825
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.81012879
123ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80471306
124* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80466801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.14880461
2MP0001835_abnormal_antigen_presentation2.92888823
3MP0000015_abnormal_ear_pigmentation2.91112296
4MP0005408_hypopigmentation2.79422476
5MP0000685_abnormal_immune_system2.64545116
6MP0005387_immune_system_phenotype2.56136110
7MP0001790_abnormal_immune_system2.56136110
8MP0003172_abnormal_lysosome_physiology2.41076835
9MP0005171_absent_coat_pigmentation2.39666166
10MP0001800_abnormal_humoral_immune2.39171170
11MP0005360_urolithiasis2.35760757
12MP0002139_abnormal_hepatobiliary_system2.26902432
13MP0005075_abnormal_melanosome_morpholog2.22641697
14MP0003436_decreased_susceptibility_to2.12435079
15MP0002166_altered_tumor_susceptibility2.08802693
16MP0003763_abnormal_thymus_physiology2.02960992
17MP0002452_abnormal_antigen_presenting1.98239653
18MP0006082_CNS_inflammation1.95927211
19MP0003252_abnormal_bile_duct1.93289518
20MP0005000_abnormal_immune_tolerance1.90838882
21MP0003300_gastrointestinal_ulcer1.88190416
22MP0002723_abnormal_immune_serum1.84960351
23MP0005365_abnormal_bile_salt1.83382035
24MP0009785_altered_susceptibility_to1.78370157
25MP0005671_abnormal_response_to1.76942672
26MP0005451_abnormal_body_composition1.76664549
27MP0004947_skin_inflammation1.76068971
28MP0005025_abnormal_response_to1.71482451
29MP0008260_abnormal_autophagy1.69380355
30MP0001819_abnormal_immune_cell1.66943810
31MP0002006_tumorigenesis1.66860267
32MP0002420_abnormal_adaptive_immunity1.66727230
33MP0005076_abnormal_cell_differentiation1.61447955
34MP0010155_abnormal_intestine_physiology1.60450736
35MP0002419_abnormal_innate_immunity1.59863453
36MP0003303_peritoneal_inflammation1.58789977
37MP0002148_abnormal_hypersensitivity_rea1.56417517
38MP0002138_abnormal_hepatobiliary_system1.55299764
39MP0005174_abnormal_tail_pigmentation1.53977768
40MP0002254_reproductive_system_inflammat1.53311454
41MP0005085_abnormal_gallbladder_physiolo1.46531390
42MP0008438_abnormal_cutaneous_collagen1.45762273
43MP0009840_abnormal_foam_cell1.45609782
44MP0002405_respiratory_system_inflammati1.42161438
45MP0008057_abnormal_DNA_replication1.41463239
46MP0002398_abnormal_bone_marrow1.40408387
47MP0003806_abnormal_nucleotide_metabolis1.40336570
48MP0002009_preneoplasia1.39915406
49MP0003724_increased_susceptibility_to1.38969268
50MP0009278_abnormal_bone_marrow1.38398517
51MP0003566_abnormal_cell_adhesion1.37573890
52MP0000716_abnormal_immune_system1.37447654
53MP0001845_abnormal_inflammatory_respons1.36413841
54MP0010352_gastrointestinal_tract_polyps1.35998476
55MP0003453_abnormal_keratinocyte_physiol1.35305048
56MP0003191_abnormal_cellular_cholesterol1.32940957
57MP0001873_stomach_inflammation1.32855850
58MP0002877_abnormal_melanocyte_morpholog1.31253094
59MP0003045_fibrosis1.30733359
60MP0003195_calcinosis1.30658225
61MP0009764_decreased_sensitivity_to1.29268492
62MP0001958_emphysema1.27057561
63MP0003136_yellow_coat_color1.26917060
64MP0000689_abnormal_spleen_morphology1.26873677
65MP0003705_abnormal_hypodermis_morpholog1.26660893
66MP0005670_abnormal_white_adipose1.26233817
67MP0000609_abnormal_liver_physiology1.26232140
68MP0005023_abnormal_wound_healing1.23665137
69MP0008469_abnormal_protein_level1.21896903
70MP0005464_abnormal_platelet_physiology1.18870891
71MP0002722_abnormal_immune_system1.17006090
72MP0001853_heart_inflammation1.15052799
73MP0009333_abnormal_splenocyte_physiolog1.13388793
74MP0000767_abnormal_smooth_muscle1.12482620
75MP0001533_abnormal_skeleton_physiology1.12266637
76MP0005058_abnormal_lysosome_morphology1.10156178
77MP0002429_abnormal_blood_cell1.09766347
78MP0003448_altered_tumor_morphology1.09429950
79MP0003950_abnormal_plasma_membrane1.07343893
80MP0005166_decreased_susceptibility_to1.03542622
81MP0002075_abnormal_coat/hair_pigmentati1.02478215
82MP0001666_abnormal_nutrient_absorption1.00530692
83MP0006054_spinal_hemorrhage0.99485571
84MP0010329_abnormal_lipoprotein_level0.99274094
85MP0008875_abnormal_xenobiotic_pharmacok0.98407901
86MP0002168_other_aberrant_phenotype0.98067591
87MP0010094_abnormal_chromosome_stability0.96898491
88MP0005257_abnormal_intraocular_pressure0.96519842
89MP0003943_abnormal_hepatobiliary_system0.96426889
90MP0002060_abnormal_skin_morphology0.96253029
91MP0000569_abnormal_digit_pigmentation0.96191918
92MP0000858_altered_metastatic_potential0.95539767
93MP0004264_abnormal_extraembryonic_tissu0.95255488
94MP0002933_joint_inflammation0.94798100
95MP0009763_increased_sensitivity_to0.94579210
96MP0003693_abnormal_embryo_hatching0.92546882
97MP0003279_aneurysm0.92355588
98MP0003075_altered_response_to0.92224902
99MP0002998_abnormal_bone_remodeling0.91787472
100MP0003091_abnormal_cell_migration0.91522193
101MP0002396_abnormal_hematopoietic_system0.91300501
102MP0000703_abnormal_thymus_morphology0.91082190
103MP0010234_abnormal_vibrissa_follicle0.90595439
104MP0002095_abnormal_skin_pigmentation0.89430155
105MP0004510_myositis0.86499003
106MP0002136_abnormal_kidney_physiology0.85738892
107MP0005310_abnormal_salivary_gland0.85646151
108MP0001915_intracranial_hemorrhage0.84982716
109MP0001186_pigmentation_phenotype0.84908342
110MP0003868_abnormal_feces_composition0.84299339
111MP0003186_abnormal_redox_activity0.83853252
112MP0003866_abnormal_defecation0.81747221
113MP0002928_abnormal_bile_duct0.81396289
114MP0008961_abnormal_basal_metabolism0.80733692
115MP0010368_abnormal_lymphatic_system0.79191862
116MP0001243_abnormal_dermal_layer0.79094715
117MP0001851_eye_inflammation0.78599792
118MP0000371_diluted_coat_color0.77539288
119MP0005390_skeleton_phenotype0.77397868
120MP0010307_abnormal_tumor_latency0.76084065
121MP0004381_abnormal_hair_follicle0.75988092
122MP0000598_abnormal_liver_morphology0.75080079
123MP0005319_abnormal_enzyme/_coenzyme0.74988801
124MP0009643_abnormal_urine_homeostasis0.74649406
125MP0004019_abnormal_vitamin_homeostasis0.74476032
126MP0004185_abnormal_adipocyte_glucose0.73110866
127MP0000249_abnormal_blood_vessel0.72046195
128MP0001545_abnormal_hematopoietic_system0.71535299
129MP0005397_hematopoietic_system_phenotyp0.71535299
130MP0004808_abnormal_hematopoietic_stem0.71288378
131MP0001216_abnormal_epidermal_layer0.69990335
132MP0005503_abnormal_tendon_morphology0.69962625
133MP0003111_abnormal_nucleus_morphology0.69798076
134MP0000490_abnormal_crypts_of0.69626807

Predicted human phenotypes

RankGene SetZ-score
1Albinism (HP:0001022)3.96307806
2Cutaneous melanoma (HP:0012056)3.92364245
3Autoimmune thrombocytopenia (HP:0001973)3.41818191
4Pustule (HP:0200039)3.37824033
5Myocardial infarction (HP:0001658)3.31351998
6Ocular albinism (HP:0001107)3.09031062
7Emphysema (HP:0002097)2.99421992
8Recurrent bronchitis (HP:0002837)2.95658857
9Eczematoid dermatitis (HP:0000976)2.88147542
10Aplasia/Hypoplasia of the fovea (HP:0008060)2.84352382
11Hypoplasia of the fovea (HP:0007750)2.84352382
12Abnormality of liposaccharide metabolism (HP:0010968)2.80168361
13Abnormality of glycosphingolipid metabolism (HP:0004343)2.80168361
14Abnormality of glycolipid metabolism (HP:0010969)2.80168361
15Abnormality of the fingertips (HP:0001211)2.78586293
16Aplasia/Hypoplasia of the macula (HP:0008059)2.77873855
17Malnutrition (HP:0004395)2.77561245
18Agammaglobulinemia (HP:0004432)2.73735713
19Systemic lupus erythematosus (HP:0002725)2.70212383
20Abnormality of macrophages (HP:0004311)2.69633963
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.69015792
22Loss of speech (HP:0002371)2.66480610
23Recurrent fungal infections (HP:0002841)2.65379987
24Abnormal gallbladder physiology (HP:0012438)2.62286994
25Cholecystitis (HP:0001082)2.62286994
26Mitral stenosis (HP:0001718)2.60504474
27Recurrent viral infections (HP:0004429)2.58975803
28Gingival bleeding (HP:0000225)2.58518395
29Myositis (HP:0100614)2.57354787
30Colitis (HP:0002583)2.57206813
31White forelock (HP:0002211)2.54046642
32Vasculitis (HP:0002633)2.53633010
33Cerebral aneurysm (HP:0004944)2.51622974
34Congenital sensorineural hearing impairment (HP:0008527)2.50000277
35Spontaneous hematomas (HP:0007420)2.49492871
36Aplasia/Hypoplasia affecting the retina (HP:0008061)2.48028205
37Elevated erythrocyte sedimentation rate (HP:0003565)2.47820758
38Patchy hypopigmentation of hair (HP:0011365)2.46208712
39Orchitis (HP:0100796)2.45359794
40Aortic aneurysm (HP:0004942)2.44980464
41Iris hypopigmentation (HP:0007730)2.43855645
42Deep venous thrombosis (HP:0002625)2.43689420
43Generalized hypopigmentation (HP:0007513)2.42211182
44Complement deficiency (HP:0004431)2.40880408
45Stomatitis (HP:0010280)2.40487707
46Recurrent abscess formation (HP:0002722)2.39746159
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39203913
48Abnormality of T cell number (HP:0011839)2.36448311
49Nasal polyposis (HP:0100582)2.35321164
50Chronic otitis media (HP:0000389)2.34537530
51Inflammation of the large intestine (HP:0002037)2.32468265
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.32145037
53Recurrent gram-negative bacterial infections (HP:0005420)2.30912619
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.30505029
55Osteolytic defects of the hand bones (HP:0009699)2.30505029
56Recurrent bacterial skin infections (HP:0005406)2.29819863
57Hypobetalipoproteinemia (HP:0003563)2.26084636
58Gastrointestinal inflammation (HP:0004386)2.25399842
59Chronic diarrhea (HP:0002028)2.25360390
60T lymphocytopenia (HP:0005403)2.23594686
61Abnormality of the nasal mucosa (HP:0000433)2.20082337
62Intrahepatic cholestasis (HP:0001406)2.18234879
63Dysostosis multiplex (HP:0000943)2.18002794
64Abnormality of pyrimidine metabolism (HP:0004353)2.17695127
65Periodontitis (HP:0000704)2.17042404
66Chronic mucocutaneous candidiasis (HP:0002728)2.17010443
67Recurrent cutaneous fungal infections (HP:0011370)2.17010443
68Lip pit (HP:0100267)2.16594735
69Joint hemorrhage (HP:0005261)2.15726796
70Hypokinesia (HP:0002375)2.14277838
71Nephritis (HP:0000123)2.13534437
72Alopecia of scalp (HP:0002293)2.12469284
73Glomerulonephritis (HP:0000099)2.11325261
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11289554
75Gastrointestinal stroma tumor (HP:0100723)2.11226007
76Broad metatarsal (HP:0001783)2.11020615
77Vacuolated lymphocytes (HP:0001922)2.08024605
78Increased IgE level (HP:0003212)2.06075219
79Optic neuritis (HP:0100653)2.06043038
80Retrobulbar optic neuritis (HP:0100654)2.06043038
81Pulmonary infiltrates (HP:0002113)2.05395765
82Poikiloderma (HP:0001029)2.03703952
83Xanthomatosis (HP:0000991)2.03676151
84Pulmonary artery stenosis (HP:0004415)2.03434084
85IgA deficiency (HP:0002720)2.03166740
86Gangrene (HP:0100758)2.02390248
87Esophageal varix (HP:0002040)2.01983051
88Lymphopenia (HP:0001888)1.98802755
89Abnormality of complement system (HP:0005339)1.98309102
90Mediastinal lymphadenopathy (HP:0100721)1.98110861
91Arterial thrombosis (HP:0004420)1.96765583
92Bilateral sensorineural hearing impairment (HP:0008619)1.96370816
93Abnormality of glutamine family amino acid metabolism (HP:0010902)1.96149614
94Entropion (HP:0000621)1.95541286
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.95452425
96Recurrent skin infections (HP:0001581)1.95154284
97Encephalitis (HP:0002383)1.94901930
98IgM deficiency (HP:0002850)1.94070348
99Cellulitis (HP:0100658)1.93853003
100Abnormal tarsal ossification (HP:0008369)1.93551343
101Increased IgM level (HP:0003496)1.93111241
102Spondylolisthesis (HP:0003302)1.92075183
103Hematochezia (HP:0002573)1.91603907
104Joint swelling (HP:0001386)1.90795869
105Eosinophilia (HP:0001880)1.90343155
106Prolonged partial thromboplastin time (HP:0003645)1.88662576
107Abnormality of the fovea (HP:0000493)1.87316730
108Restrictive lung disease (HP:0002091)1.85410266
109Leukocytosis (HP:0001974)1.84992196
110Small epiphyses (HP:0010585)1.84970151
111Keratoconjunctivitis sicca (HP:0001097)1.84815144
112Recurrent sinusitis (HP:0011108)1.84078195
113Lower limb hyperreflexia (HP:0002395)1.83886609
114Aortic dissection (HP:0002647)1.82867313
115Blue irides (HP:0000635)1.82120378
116Gingivitis (HP:0000230)1.82022273
117Abnormality of T cells (HP:0002843)1.81141674
118Combined immunodeficiency (HP:0005387)1.80891846
119Abnormality of lateral ventricle (HP:0030047)1.79910468
120Urinary glycosaminoglycan excretion (HP:0003541)1.77867687
121Mucopolysacchariduria (HP:0008155)1.77867687
122Keratitis (HP:0000491)1.77179821
123Aneurysm (HP:0002617)1.76627389
124Osteomyelitis (HP:0002754)1.76470058
125Hydroxyprolinuria (HP:0003080)1.76139392
126Abnormality of proline metabolism (HP:0010907)1.76139392
127Meningitis (HP:0001287)1.75844098
128Hypoproteinemia (HP:0003075)1.75674301
129Epidermoid cyst (HP:0200040)1.75520136
130Tongue fasciculations (HP:0001308)1.75136576
131Parakeratosis (HP:0001036)1.74541440
132Congenital ichthyosiform erythroderma (HP:0007431)1.74433750
133Thin bony cortex (HP:0002753)1.74084115
134Fatigue (HP:0012378)1.73735442
135Leukopenia (HP:0001882)1.73563223
136Abnormality of the preputium (HP:0100587)1.73474356
137Thick nail (HP:0001805)1.72664570
138Increased CSF protein (HP:0002922)1.72292409
139Hypochromic anemia (HP:0001931)1.71893266
140Turricephaly (HP:0000262)1.70109864
141Chronic sinusitis (HP:0011109)1.68238752
142Epistaxis (HP:0000421)1.67716532
143Abnormal platelet volume (HP:0011876)1.66979027
144Hypergammaglobulinemia (HP:0010702)1.66615469
145Abnormality of sulfur amino acid metabolism (HP:0004339)1.66317541
146Abnormality of polysaccharide metabolism (HP:0011012)1.65778289
147Abnormality of glycosaminoglycan metabolism (HP:0004371)1.65778289
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.65778289
149Polycythemia (HP:0001901)1.65286397
150Hemoptysis (HP:0002105)1.65032140
151Abnormality of the common coagulation pathway (HP:0010990)1.64952003
152Hypochromic microcytic anemia (HP:0004840)1.64348462
153Aortic regurgitation (HP:0001659)1.64291063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.49117093
2ERN13.37237197
3MAP4K13.28549405
4MAP3K143.06745988
5TYK23.00565161
6CDK122.84047283
7FGFR42.74599450
8STK38L2.57127928
9SMG12.39278923
10JAK32.38137447
11MAP3K102.21105326
12JAK12.09962027
13EPHA32.09404856
14IKBKE2.07554569
15MAP3K131.91953923
16TGFBR21.90553428
17EIF2AK31.88266379
18TBK11.87526267
19STK101.86859542
20PRPF4B1.79156284
21TXK1.76674844
22CSK1.70443574
23EIF2AK11.70396015
24IKBKB1.68312272
25CHUK1.64208219
26SIK11.58418038
27PASK1.57416317
28BLK1.55674163
29IRAK31.54832643
30ZAP701.47563158
31FRK1.37385678
32MAPK151.37317871
33FER1.36068452
34TAOK31.34133616
35FGFR31.30442761
36ITK1.28747166
37PTK61.24133088
38RIPK11.23725609
39KIT1.20157210
40NME21.18667088
41ICK1.17225634
42TAOK11.16604762
43EPHB11.15845588
44SIK31.12236794
45BTK1.11841531
46CSF1R1.07510583
47BRD41.06560905
48TSSK61.06327811
49NEK91.05875920
50BMX1.05685422
51HCK1.04707597
52BUB11.04395272
53FLT31.03108713
54GRK61.02488018
55CAMK1D1.02417859
56NLK1.01679919
57LCK1.00283982
58PAK41.00245861
59RIPK40.99429680
60LATS10.98325193
61PKN20.97308644
62STK380.96628884
63MARK30.95920240
64PRKCI0.92638721
65PIM10.91472733
66IRAK40.90293670
67PDGFRA0.90116599
68MAPK110.90039998
69EEF2K0.87982281
70ACVR1B0.86783293
71TTN0.86733850
72BRSK20.86607029
73INSRR0.85818238
74TRIB30.84707582
75TRPM70.84015008
76FGFR20.83646487
77STK390.83169893
78MTOR0.79639043
79MAP2K30.79504637
80STK30.77388221
81MAP3K70.75361449
82IRAK20.73362475
83JAK20.71539425
84CDK60.71009036
85NUAK10.70870267
86SYK0.67305799
87DDR20.66891513
88DYRK1B0.65969090
89SIK20.65581743
90MAPKAPK30.63548444
91GSK3A0.63456902
92MAP3K30.62897656
93STK240.62566602
94EPHA20.62187203
95LYN0.62066928
96LRRK20.61798568
97BRSK10.61326492
98TAOK20.59616703
99MAPK70.59124944
100HIPK20.58042889
101RPS6KA40.57864282
102MELK0.57760555
103FGR0.57639565
104CDC42BPA0.57583706
105WEE10.55810687
106PTK20.54617329
107VRK20.54238294
108PDGFRB0.52533396
109KDR0.52332862
110PRKD20.51597854
111TNK20.51203934
112STK40.51120269
113EPHB20.50507271
114CAMK1G0.50499376
115CDK40.48453632
116ABL10.47512170
117PRKCQ0.47465246
118MST1R0.47303772
119CDK90.45816443
120TEC0.45279860
121YES10.44990049
122PRKD30.44916956
123CDK70.43268553
124MST40.42682592
125MAP2K20.41816967
126INSR0.40224770
127EGFR0.39056919
128IRAK10.37792228
129PIK3CG0.37702308
130MAPKAPK20.37650326
131BMPR20.37573156
132MAP3K10.36700552
133TGFBR10.34939255
134PRKAA20.34409669
135PAK30.32554894
136MAP3K120.32317592
137PRKCH0.30528188
138MAP3K80.30458668
139BCR0.30264129
140PDPK10.28346068
141FGFR10.27792297

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.50324621
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.42372939
3Staphylococcus aureus infection_Homo sapiens_hsa051502.39600010
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.27535119
5Complement and coagulation cascades_Homo sapiens_hsa046102.22770941
6Type I diabetes mellitus_Homo sapiens_hsa049402.05325190
7Measles_Homo sapiens_hsa051621.96954171
8Leishmaniasis_Homo sapiens_hsa051401.92305161
9Asthma_Homo sapiens_hsa053101.89651141
10Caffeine metabolism_Homo sapiens_hsa002321.85647472
11B cell receptor signaling pathway_Homo sapiens_hsa046621.84790756
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84715054
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81553625
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.78536468
15Osteoclast differentiation_Homo sapiens_hsa043801.73405785
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71038565
17Lysine degradation_Homo sapiens_hsa003101.70809713
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.60672077
19Herpes simplex infection_Homo sapiens_hsa051681.54671106
20Proteasome_Homo sapiens_hsa030501.53566849
21Sphingolipid metabolism_Homo sapiens_hsa006001.52081417
22Influenza A_Homo sapiens_hsa051641.51112002
23Fructose and mannose metabolism_Homo sapiens_hsa000511.47935328
24Tryptophan metabolism_Homo sapiens_hsa003801.47878390
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45290616
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45029043
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42560380
28Toxoplasmosis_Homo sapiens_hsa051451.42061710
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40682764
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39157996
31TNF signaling pathway_Homo sapiens_hsa046681.35095036
32Hematopoietic cell lineage_Homo sapiens_hsa046401.33270826
33T cell receptor signaling pathway_Homo sapiens_hsa046601.32297048
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.31625030
35Antigen processing and presentation_Homo sapiens_hsa046121.28869459
36ABC transporters_Homo sapiens_hsa020101.23473825
37Graft-versus-host disease_Homo sapiens_hsa053321.20665068
38Apoptosis_Homo sapiens_hsa042101.20299549
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.20238933
40Notch signaling pathway_Homo sapiens_hsa043301.17044901
41N-Glycan biosynthesis_Homo sapiens_hsa005101.15303830
42Hepatitis C_Homo sapiens_hsa051601.14431517
43Viral myocarditis_Homo sapiens_hsa054161.13327532
44Allograft rejection_Homo sapiens_hsa053301.12292178
45Small cell lung cancer_Homo sapiens_hsa052221.11548910
46Arginine biosynthesis_Homo sapiens_hsa002201.07307958
47Legionellosis_Homo sapiens_hsa051341.05240844
48Acute myeloid leukemia_Homo sapiens_hsa052211.05048350
49Chronic myeloid leukemia_Homo sapiens_hsa052201.03956678
50Hepatitis B_Homo sapiens_hsa051611.00446324
51African trypanosomiasis_Homo sapiens_hsa051430.99909856
52Rheumatoid arthritis_Homo sapiens_hsa053230.98368296
53Malaria_Homo sapiens_hsa051440.97826692
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97493652
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97406834
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.96530440
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94737686
58Adherens junction_Homo sapiens_hsa045200.92442807
59Pertussis_Homo sapiens_hsa051330.92421737
60PPAR signaling pathway_Homo sapiens_hsa033200.92397851
61Pancreatic cancer_Homo sapiens_hsa052120.91747412
62Chemical carcinogenesis_Homo sapiens_hsa052040.91552949
63Galactose metabolism_Homo sapiens_hsa000520.91483233
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89940908
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.89472406
66Sulfur metabolism_Homo sapiens_hsa009200.87926855
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86570196
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86199736
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86176436
70Tuberculosis_Homo sapiens_hsa051520.84097653
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82855174
72Pentose phosphate pathway_Homo sapiens_hsa000300.82504180
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80006912
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79661045
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79451806
76Shigellosis_Homo sapiens_hsa051310.78399014
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75848082
78Retinol metabolism_Homo sapiens_hsa008300.75599242
79Chemokine signaling pathway_Homo sapiens_hsa040620.73904204
80Vitamin digestion and absorption_Homo sapiens_hsa049770.71783775
81Other glycan degradation_Homo sapiens_hsa005110.71761177
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.71568286
83Non-homologous end-joining_Homo sapiens_hsa034500.71228485
84Insulin resistance_Homo sapiens_hsa049310.71060543
85Lysosome_Homo sapiens_hsa041420.70865778
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.70499679
87Histidine metabolism_Homo sapiens_hsa003400.68859978
88Fatty acid degradation_Homo sapiens_hsa000710.67400688
89MicroRNAs in cancer_Homo sapiens_hsa052060.67273410
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66294162
91Fat digestion and absorption_Homo sapiens_hsa049750.65086567
92Prolactin signaling pathway_Homo sapiens_hsa049170.65070235
93Autoimmune thyroid disease_Homo sapiens_hsa053200.63755971
94Prostate cancer_Homo sapiens_hsa052150.62347917
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.61732559
96HTLV-I infection_Homo sapiens_hsa051660.61439004
97One carbon pool by folate_Homo sapiens_hsa006700.60606350
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59907229
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59842567
100Amoebiasis_Homo sapiens_hsa051460.58597804
101Glutathione metabolism_Homo sapiens_hsa004800.58558251
102Proteoglycans in cancer_Homo sapiens_hsa052050.58210033
103Bile secretion_Homo sapiens_hsa049760.57640007
104p53 signaling pathway_Homo sapiens_hsa041150.56095589
105Prion diseases_Homo sapiens_hsa050200.54271661
106Epstein-Barr virus infection_Homo sapiens_hsa051690.53923051
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53602816
108Peroxisome_Homo sapiens_hsa041460.52995420
109Selenocompound metabolism_Homo sapiens_hsa004500.52241708
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51984483
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.51587307
112Bladder cancer_Homo sapiens_hsa052190.49966523
113Phagosome_Homo sapiens_hsa041450.49769838
114Vibrio cholerae infection_Homo sapiens_hsa051100.47715311
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47106539
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45434452
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45089070
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44910972
119Viral carcinogenesis_Homo sapiens_hsa052030.44132281
120Salmonella infection_Homo sapiens_hsa051320.43908072
121TGF-beta signaling pathway_Homo sapiens_hsa043500.43662529
122Tyrosine metabolism_Homo sapiens_hsa003500.42469828
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42172257
124Focal adhesion_Homo sapiens_hsa045100.41846227
125Pathways in cancer_Homo sapiens_hsa052000.41582126
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41563702
127Starch and sucrose metabolism_Homo sapiens_hsa005000.40181980
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37168678
129VEGF signaling pathway_Homo sapiens_hsa043700.35908187
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34776989
131Non-small cell lung cancer_Homo sapiens_hsa052230.33570495
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31525107

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