ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of synaptic transmission, GABAergic (GO:0032229)	5.74906005
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.56852100
3	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	5.39242996
4	gamma-aminobutyric acid transport (GO:0015812)	5.31308109
5	glyoxylate metabolic process (GO:0046487)	5.22059162
6	presynaptic membrane assembly (GO:0097105)	4.89513407
7	neuron cell-cell adhesion (GO:0007158)	4.51133226
8	nucleobase catabolic process (GO:0046113)	4.47177316
9	dopamine biosynthetic process (GO:0042416)	4.25312953
10	synaptic vesicle exocytosis (GO:0016079)	4.16072086
11	presynaptic membrane organization (GO:0097090)	4.07421142
12	short-term memory (GO:0007614)	4.05677094
13	alkaloid metabolic process (GO:0009820)	4.01186519
14	cellular ketone body metabolic process (GO:0046950)	3.89780837
15	seminiferous tubule development (GO:0072520)	3.88004214
16	vocalization behavior (GO:0071625)	3.81720069
17	regulation of feeding behavior (GO:0060259)	3.71512928
18	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.70868845
19	coenzyme catabolic process (GO:0009109)	3.67514962
20	negative regulation of activin receptor signaling pathway (GO:0032926)	3.64875491
21	regulation of dopamine secretion (GO:0014059)	3.55296884
22	auditory receptor cell stereocilium organization (GO:0060088)	3.48550236
23	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.46482604
24	ketone body metabolic process (GO:1902224)	3.42564733
25	serotonin receptor signaling pathway (GO:0007210)	3.40623952
26	detection of calcium ion (GO:0005513)	3.25444405
27	positive regulation of mitochondrial fission (GO:0090141)	3.23985722
28	cofactor catabolic process (GO:0051187)	3.22700904
29	neural tube formation (GO:0001841)	3.16539494
30	negative regulation of mast cell activation (GO:0033004)	3.11223539
31	hormone catabolic process (GO:0042447)	3.10918638
32	C4-dicarboxylate transport (GO:0015740)	3.06996692
33	cAMP-mediated signaling (GO:0019933)	3.06636925
34	neurotransmitter-gated ion channel clustering (GO:0072578)	3.04998004
35	postsynaptic membrane organization (GO:0001941)	3.04536884
36	peroxisome fission (GO:0016559)	3.03977324
37	catechol-containing compound biosynthetic process (GO:0009713)	3.00661512
38	catecholamine biosynthetic process (GO:0042423)	3.00661512
39	serine family amino acid catabolic process (GO:0009071)	2.98843326
40	neuron recognition (GO:0008038)	2.97820415
41	cell wall macromolecule catabolic process (GO:0016998)	2.97772970
42	inner ear receptor stereocilium organization (GO:0060122)	2.94171232
43	ADP metabolic process (GO:0046031)	2.92167041
44	regulation of pigment cell differentiation (GO:0050932)	2.90407645
45	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.87637970
46	regulation of sequestering of triglyceride (GO:0010889)	2.87363904
47	head development (GO:0060322)	2.87147638
48	synapsis (GO:0007129)	2.81436039
49	synapse assembly (GO:0007416)	2.80347547
50	regulation of protein glycosylation (GO:0060049)	2.74973461
51	indolalkylamine metabolic process (GO:0006586)	2.74786769
52	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.74599284
53	auditory behavior (GO:0031223)	2.74107498
54	transmission of nerve impulse (GO:0019226)	2.69514903
55	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.65772905
56	cell junction maintenance (GO:0034331)	2.65226954
57	coronary vasculature morphogenesis (GO:0060977)	2.63980946
58	regulation of triglyceride catabolic process (GO:0010896)	2.63819048
59	regulation of response to osmotic stress (GO:0047484)	2.63713280
60	positive regulation of membrane potential (GO:0045838)	2.63654288
61	cell wall macromolecule metabolic process (GO:0044036)	2.63438732
62	limb bud formation (GO:0060174)	2.62993254
63	oxidative demethylation (GO:0070989)	2.62228682
64	urinary tract smooth muscle contraction (GO:0014848)	2.61936588
65	sex differentiation (GO:0007548)	2.59852252
66	negative regulation of synaptic transmission (GO:0050805)	2.57536443
67	quinone metabolic process (GO:1901661)	2.56706575
68	phenylpropanoid metabolic process (GO:0009698)	2.56340942
69	positive regulation of catecholamine secretion (GO:0033605)	2.55957704
70	intra-S DNA damage checkpoint (GO:0031573)	2.55080182
71	cardiac ventricle formation (GO:0003211)	2.55075679
72	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.54901410
73	growth hormone secretion (GO:0030252)	2.53937850
74	viral mRNA export from host cell nucleus (GO:0046784)	2.53099710
75	daunorubicin metabolic process (GO:0044597)	2.52868301
76	polyketide metabolic process (GO:0030638)	2.52868301
77	doxorubicin metabolic process (GO:0044598)	2.52868301
78	drug catabolic process (GO:0042737)	2.52304156
79	S-adenosylmethionine metabolic process (GO:0046500)	2.49866519
80	acetyl-CoA metabolic process (GO:0006084)	2.49667924
81	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.47716232
82	gonadal mesoderm development (GO:0007506)	2.47500784
83	regulation of phospholipase A2 activity (GO:0032429)	2.45914003
84	regulation of activin receptor signaling pathway (GO:0032925)	2.45913254
85	sulfur amino acid catabolic process (GO:0000098)	2.45296312
86	C-terminal protein amino acid modification (GO:0018410)	2.45113035
87	copper ion transport (GO:0006825)	2.43747929
88	water-soluble vitamin biosynthetic process (GO:0042364)	2.42564882
89	cardiac chamber formation (GO:0003207)	2.42373491
90	C-terminal protein lipidation (GO:0006501)	2.39377076
91	mechanosensory behavior (GO:0007638)	2.37021196
92	cullin deneddylation (GO:0010388)	2.36879877
93	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.36737320
94	activation of protein kinase B activity (GO:0032148)	2.36187476
95	amino-acid betaine metabolic process (GO:0006577)	2.35321625
96	positive regulation of amine transport (GO:0051954)	2.34742693
97	negative regulation of microtubule polymerization (GO:0031115)	2.34019153
98	retinal metabolic process (GO:0042574)	2.32451897
99	regulation of mitochondrial fission (GO:0090140)	2.32392791
100	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.31549920

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.44627655
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.83529887
3	VDR_22108803_ChIP-Seq_LS180_Human	3.82058067
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.53177307
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.31535083
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.84825583
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.68168468
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62672459
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.54613011
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.51377582
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.45881466
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.34542212
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33749793
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.32497337
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.29699637
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27322378
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.25248831
18	FUS_26573619_Chip-Seq_HEK293_Human	2.24931473
19	P300_19829295_ChIP-Seq_ESCs_Human	2.11063143
20	AR_21572438_ChIP-Seq_LNCaP_Human	2.07963782
21	EWS_26573619_Chip-Seq_HEK293_Human	2.07393174
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99190372
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.94885049
24	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.86529854
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85055718
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.77431050
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.75564294
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71505983
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70614031
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.70614031
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70525379
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.68755842
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68070541
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66581671
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65913337
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64656250
37	AR_25329375_ChIP-Seq_VCAP_Human	1.64327757
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.60802223
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60188364
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55019466
41	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51487600
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46649100
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46537537
44	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45004721
45	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44601400
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44543988
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43658371
48	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.41036533
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40644835
50	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.39764078
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.38916661
52	STAT3_23295773_ChIP-Seq_U87_Human	1.37641329
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36708512
54	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34593211
55	TCF4_23295773_ChIP-Seq_U87_Human	1.29134034
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23105010
57	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.21042227
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20605748
59	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16999624
60	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.16981575
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16257161
62	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14112299
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13348573
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12901221
65	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11910520
66	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11297757
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09793079
68	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08797429
69	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07354905
70	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.06996316
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06257840
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06242590
73	KDM2B_26808549_Chip-Seq_REH_Human	1.04529997
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.03796392
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03058440
76	NCOR_22424771_ChIP-Seq_293T_Human	1.02887767
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02801236
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02801236
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01865778
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01787806
81	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.01048076
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00592253
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95813428
84	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.95582098
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95546082
86	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94482014
87	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.94436325
88	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94213608
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94201593
90	JUN_21703547_ChIP-Seq_K562_Human	0.94133278
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.94009133
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93199446
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92351525
94	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.92199073
95	RXR_22108803_ChIP-Seq_LS180_Human	0.91362371
96	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91042737
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90796628
98	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.90219806
99	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.89558312
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89236314

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	5.75634521
2	MP0003787_abnormal_imprinting	3.79221382
3	MP0002735_abnormal_chemical_nociception	2.90793765
4	MP0002102_abnormal_ear_morphology	2.88608950
5	MP0004859_abnormal_synaptic_plasticity	2.63577842
6	MP0003121_genomic_imprinting	2.32788693
7	MP0002139_abnormal_hepatobiliary_system	2.30992172
8	MP0001501_abnormal_sleep_pattern	2.30126722
9	MP0003122_maternal_imprinting	2.18539142
10	MP0001529_abnormal_vocalization	2.15640502
11	MP0003868_abnormal_feces_composition	2.10966884
12	MP0001968_abnormal_touch/_nociception	2.07025702
13	MP0009046_muscle_twitch	2.07018465
14	MP0001986_abnormal_taste_sensitivity	2.06035028
15	MP0009697_abnormal_copulation	2.05493933
16	MP0005187_abnormal_penis_morphology	1.99198362
17	MP0008995_early_reproductive_senescence	1.98417222
18	MP0001984_abnormal_olfaction	1.92740998
19	MP0002736_abnormal_nociception_after	1.92710412
20	MP0002234_abnormal_pharynx_morphology	1.91560260
21	MP0002272_abnormal_nervous_system	1.86987820
22	MP0005423_abnormal_somatic_nervous	1.86486401
23	MP0003635_abnormal_synaptic_transmissio	1.82615189
24	MP0005645_abnormal_hypothalamus_physiol	1.80855647
25	MP0008877_abnormal_DNA_methylation	1.73210410
26	MP0004270_analgesia	1.66466841
27	MP0002876_abnormal_thyroid_physiology	1.65873675
28	MP0002138_abnormal_hepatobiliary_system	1.65477772
29	MP0004924_abnormal_behavior	1.64310557
30	MP0005386_behavior/neurological_phenoty	1.64310557
31	MP0009745_abnormal_behavioral_response	1.62905651
32	MP0002064_seizures	1.59192525
33	MP0003880_abnormal_central_pattern	1.58538630
34	MP0003718_maternal_effect	1.57644966
35	MP0003385_abnormal_body_wall	1.56047253
36	MP0002653_abnormal_ependyma_morphology	1.55553446
37	MP0001764_abnormal_homeostasis	1.52707920
38	MP0005646_abnormal_pituitary_gland	1.50606408
39	MP0004142_abnormal_muscle_tone	1.49148317
40	MP0003890_abnormal_embryonic-extraembry	1.47045552
41	MP0006276_abnormal_autonomic_nervous	1.44651463
42	MP0002837_dystrophic_cardiac_calcinosis	1.44469789
43	MP0001486_abnormal_startle_reflex	1.43396512
44	MP0002638_abnormal_pupillary_reflex	1.37664232
45	MP0000749_muscle_degeneration	1.37056444
46	MP0002009_preneoplasia	1.35578271
47	MP0001502_abnormal_circadian_rhythm	1.32415060
48	MP0005408_hypopigmentation	1.32040937
49	MP0003806_abnormal_nucleotide_metabolis	1.29367871
50	MP0002909_abnormal_adrenal_gland	1.27960086
51	MP0003011_delayed_dark_adaptation	1.24621014
52	MP0004133_heterotaxia	1.24465646
53	MP0002063_abnormal_learning/memory/cond	1.22801490
54	MP0002572_abnormal_emotion/affect_behav	1.22591794
55	MP0009780_abnormal_chondrocyte_physiolo	1.20671850
56	MP0005253_abnormal_eye_physiology	1.20655546
57	MP0004147_increased_porphyrin_level	1.20399310
58	MP0005499_abnormal_olfactory_system	1.18330634
59	MP0005394_taste/olfaction_phenotype	1.18330634
60	MP0006072_abnormal_retinal_apoptosis	1.18121403
61	MP0002557_abnormal_social/conspecific_i	1.17626828
62	MP0010386_abnormal_urinary_bladder	1.17326436
63	MP0003119_abnormal_digestive_system	1.16486484
64	MP0000049_abnormal_middle_ear	1.14006528
65	MP0001188_hyperpigmentation	1.12916384
66	MP0005551_abnormal_eye_electrophysiolog	1.11262269
67	MP0003195_calcinosis	1.11185731
68	MP0004742_abnormal_vestibular_system	1.10032702
69	MP0000631_abnormal_neuroendocrine_gland	1.09775496
70	MP0008875_abnormal_xenobiotic_pharmacok	1.09663610
71	MP0003646_muscle_fatigue	1.09597216
72	MP0001905_abnormal_dopamine_level	1.04413334
73	MP0005360_urolithiasis	1.03322239
74	MP0003315_abnormal_perineum_morphology	1.01531425
75	MP0002067_abnormal_sensory_capabilities	1.00341055
76	MP0001970_abnormal_pain_threshold	0.99783628
77	MP0008789_abnormal_olfactory_epithelium	0.96257977
78	MP0000013_abnormal_adipose_tissue	0.96101236
79	MP0002184_abnormal_innervation	0.95587807
80	MP0000516_abnormal_urinary_system	0.95024612
81	MP0005367_renal/urinary_system_phenotyp	0.95024612
82	MP0000750_abnormal_muscle_regeneration	0.94263502
83	MP0002733_abnormal_thermal_nociception	0.93599795
84	MP0008058_abnormal_DNA_repair	0.92188033
85	MP0003252_abnormal_bile_duct	0.91719459
86	MP0002734_abnormal_mechanical_nocicepti	0.91604680
87	MP0005085_abnormal_gallbladder_physiolo	0.90988584
88	MP0000538_abnormal_urinary_bladder	0.87054604
89	MP0002882_abnormal_neuron_morphology	0.85296204
90	MP0004811_abnormal_neuron_physiology	0.84278509
91	MP0000778_abnormal_nervous_system	0.82421505
92	MP0000955_abnormal_spinal_cord	0.82362426
93	MP0005266_abnormal_metabolism	0.77681655
94	MP0004215_abnormal_myocardial_fiber	0.77119907
95	MP0002332_abnormal_exercise_endurance	0.77046986
96	MP0002066_abnormal_motor_capabilities/c	0.76947057
97	MP0002751_abnormal_autonomic_nervous	0.76046759
98	MP0002069_abnormal_eating/drinking_beha	0.75264988
99	MP0005535_abnormal_body_temperature	0.73648628
100	MP0002752_abnormal_somatic_nervous	0.70676758

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent speech (HP:0001344)	5.49533454
2	Hyperventilation (HP:0002883)	4.41587996
3	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	4.10852439
4	Short 1st metacarpal (HP:0010034)	4.10852439
5	Limb dystonia (HP:0002451)	3.92237538
6	Hepatoblastoma (HP:0002884)	3.84242066
7	Intestinal atresia (HP:0011100)	3.68091355
8	Abnormality of the 1st metacarpal (HP:0010009)	3.60716647
9	Abnormality of the columella (HP:0009929)	3.56549294
10	Epidermoid cyst (HP:0200040)	3.50257769
11	Abnormal biliary tract physiology (HP:0012439)	3.47803921
12	Bile duct proliferation (HP:0001408)	3.47803921
13	Protruding tongue (HP:0010808)	3.47395196
14	Volvulus (HP:0002580)	3.46653800
15	Widely spaced teeth (HP:0000687)	3.35514357
16	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.29289812
17	Pancreatic cysts (HP:0001737)	3.27954917
18	Atonic seizures (HP:0010819)	3.23419198
19	Tented upper lip vermilion (HP:0010804)	3.19235394
20	True hermaphroditism (HP:0010459)	3.15700963
21	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.13752879
22	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.13752879
23	Pancreatic fibrosis (HP:0100732)	3.03808581
24	Hypochromic microcytic anemia (HP:0004840)	2.95490028
25	Facial hemangioma (HP:0000329)	2.93472444
26	Large earlobe (HP:0009748)	2.91499084
27	Abnormality of the frontal sinuses (HP:0002687)	2.89381111
28	Abnormality of midbrain morphology (HP:0002418)	2.87640884
29	Molar tooth sign on MRI (HP:0002419)	2.87640884
30	Thickened helices (HP:0000391)	2.85352735
31	Methylmalonic acidemia (HP:0002912)	2.82148140
32	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.81551785
33	Intellectual disability, progressive (HP:0006887)	2.76436241
34	Long clavicles (HP:0000890)	2.72593874
35	Gaze-evoked nystagmus (HP:0000640)	2.71980114
36	Inability to walk (HP:0002540)	2.70773099
37	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.68513293
38	Type II lissencephaly (HP:0007260)	2.55174169
39	Cupped ear (HP:0000378)	2.47983324
40	Retinal dysplasia (HP:0007973)	2.43759183
41	Hypothermia (HP:0002045)	2.39463830
42	Drooling (HP:0002307)	2.37848702
43	Urinary urgency (HP:0000012)	2.37600365
44	Morphological abnormality of the pyramidal tract (HP:0002062)	2.36669400
45	Progressive inability to walk (HP:0002505)	2.35797026
46	Abnormality of the corticospinal tract (HP:0002492)	2.34614696
47	Cystic liver disease (HP:0006706)	2.32156839
48	Male pseudohermaphroditism (HP:0000037)	2.31535331
49	Genetic anticipation (HP:0003743)	2.30859121
50	Limb hypertonia (HP:0002509)	2.29272036
51	Tapered finger (HP:0001182)	2.28335087
52	Infantile muscular hypotonia (HP:0008947)	2.28060784
53	Reduced antithrombin III activity (HP:0001976)	2.27441593
54	Submucous cleft hard palate (HP:0000176)	2.26512229
55	Cerebellar dysplasia (HP:0007033)	2.23891834
56	Esotropia (HP:0000565)	2.20356813
57	Amblyopia (HP:0000646)	2.18592075
58	Short phalanx of the thumb (HP:0009660)	2.15533321
59	Excessive salivation (HP:0003781)	2.14652422
60	Intellectual disability, severe (HP:0010864)	2.12239443
61	Bifid tongue (HP:0010297)	2.11871785
62	Gastroesophageal reflux (HP:0002020)	2.10644063
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.10214907
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.10214907
65	Optic nerve hypoplasia (HP:0000609)	2.09458758
66	Homocystinuria (HP:0002156)	2.08744751
67	Abnormality of homocysteine metabolism (HP:0010919)	2.08744751
68	Broad-based gait (HP:0002136)	2.06718075
69	Cerebral hypomyelination (HP:0006808)	2.06633198
70	Agitation (HP:0000713)	2.05304466
71	Open mouth (HP:0000194)	2.02316392
72	Frequent falls (HP:0002359)	2.02208669
73	Abnormality of fatty-acid metabolism (HP:0004359)	2.01769189
74	Abnormality of the labia minora (HP:0012880)	2.00083687
75	Exotropia (HP:0000577)	1.99890695
76	Widely patent fontanelles and sutures (HP:0004492)	1.99328611
77	Macroglossia (HP:0000158)	1.97811775
78	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.97674399
79	Nephronophthisis (HP:0000090)	1.95327284
80	Abnormality of vitamin B metabolism (HP:0004340)	1.95114315
81	Epileptic encephalopathy (HP:0200134)	1.94342168
82	Lissencephaly (HP:0001339)	1.92784417
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89719033
84	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.89003193
85	Anencephaly (HP:0002323)	1.88362481
86	Decreased lacrimation (HP:0000633)	1.88291924
87	Alacrima (HP:0000522)	1.87858812
88	Impaired smooth pursuit (HP:0007772)	1.87540802
89	Insidious onset (HP:0003587)	1.85023218
90	Termporal pattern (HP:0011008)	1.85023218
91	Abnormality of methionine metabolism (HP:0010901)	1.84229052
92	Sclerocornea (HP:0000647)	1.83437614
93	Narrow forehead (HP:0000341)	1.80253659
94	Methylmalonic aciduria (HP:0012120)	1.79287313
95	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.78889302
96	Autoamputation (HP:0001218)	1.78531562
97	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.76955795
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75958158
99	Gastrointestinal atresia (HP:0002589)	1.74840543
100	Abnormality of vitamin metabolism (HP:0100508)	1.74122927

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.28532025
2	CASK	4.85551283
3	PINK1	4.34589872
4	MARK1	3.37129171
5	PRKD3	3.28069796
6	MAP2K7	3.09834135
7	MAPK13	2.68614470
8	MAP3K4	2.64135953
9	EPHA3	2.36874232
10	STK38L	2.29711182
11	CSNK1G3	1.93871685
12	CSNK1G2	1.89132238
13	OBSCN	1.86814245
14	CSNK1A1L	1.85587564
15	PIK3CG	1.78702066
16	TRIM28	1.68552246
17	BCKDK	1.63185281
18	MAP3K12	1.62348773
19	MAP4K2	1.53725748
20	PDK2	1.48770371
21	AKT3	1.46851225
22	CSNK1G1	1.46846706
23	NTRK2	1.43221009
24	WNK3	1.42548883
25	INSRR	1.41311761
26	GRK1	1.39408339
27	MARK3	1.35071669
28	NEK2	1.31470192
29	SCYL2	1.26884606
30	BCR	1.22132822
31	UHMK1	1.19911562
32	MAPKAPK5	1.17066558
33	MYLK	1.08729585
34	PIK3CA	1.04805410
35	GRK7	1.04414067
36	ERBB4	1.00571982
37	NEK6	0.98833892
38	ERBB2	0.91361057
39	BUB1	0.90418567
40	MAP2K4	0.88879947
41	TLK1	0.79946924
42	CDK9	0.78061065
43	SRPK1	0.77528418
44	WNK4	0.75645363
45	BMPR1B	0.74907351
46	PAK3	0.74165387
47	ADRBK2	0.74096361
48	DYRK2	0.74029095
49	FER	0.70795389
50	CDK5	0.68400087
51	MINK1	0.67003913
52	CDK14	0.66377816
53	CDK18	0.66164327
54	CDK15	0.59726727
55	CAMK2A	0.58915373
56	DYRK3	0.58074984
57	PRKCG	0.56954059
58	CDK3	0.56603247
59	MUSK	0.55766714
60	CSNK1A1	0.55712506
61	STK24	0.55654822
62	CAMK2B	0.54331231
63	MAP3K9	0.53698654
64	CSNK1D	0.53477747
65	RPS6KA5	0.53292890
66	SGK494	0.52492138
67	SGK223	0.52492138
68	PRKACA	0.52265902
69	PRKCZ	0.50154393
70	PRKCE	0.48910999
71	RPS6KB1	0.48660245
72	CDK11A	0.46868385
73	FGFR2	0.44759948
74	MAP3K5	0.43986889
75	GRK5	0.43585400
76	ACVR1B	0.43202498
77	CAMK2G	0.42682881
78	SGK2	0.42065546
79	ZAK	0.41368492
80	MAPKAPK3	0.41253636
81	PRKG2	0.41200344
82	PRKACB	0.40987514
83	PRKG1	0.40712755
84	EPHA4	0.39805347
85	SGK1	0.36479956
86	FGR	0.36263358
87	RPS6KA3	0.35119476
88	PRKACG	0.34925696
89	TIE1	0.34666921
90	CAMK2D	0.34274532
91	DYRK1A	0.34257612
92	TNK2	0.30551256
93	NTRK3	0.29983176
94	MAPK12	0.27163850
95	SIK3	0.25252942
96	PRKAA1	0.25143026
97	ATM	0.24446410
98	PRKD2	0.23634756
99	DYRK1B	0.22631628
100	CSNK1E	0.22529063

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.34861712
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.22333984
3	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.76131783
4	Nicotine addiction_Homo sapiens_hsa05033	2.72476885
5	Butanoate metabolism_Homo sapiens_hsa00650	2.46690946
6	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.18228158
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.11325009
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10346425
9	Phenylalanine metabolism_Homo sapiens_hsa00360	2.03877210
10	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.02443004
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.98925520
12	Peroxisome_Homo sapiens_hsa04146	1.96849339
13	GABAergic synapse_Homo sapiens_hsa04727	1.89645363
14	Chemical carcinogenesis_Homo sapiens_hsa05204	1.82710018
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.80439197
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73449190
17	beta-Alanine metabolism_Homo sapiens_hsa00410	1.72864900
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.70355667
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.70250786
20	Propanoate metabolism_Homo sapiens_hsa00640	1.69729414
21	Taste transduction_Homo sapiens_hsa04742	1.68690672
22	Retinol metabolism_Homo sapiens_hsa00830	1.61354882
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.55385281
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.54093786
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53954225
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47169563
27	Circadian entrainment_Homo sapiens_hsa04713	1.38003427
28	Histidine metabolism_Homo sapiens_hsa00340	1.37548903
29	Sulfur metabolism_Homo sapiens_hsa00920	1.35695760
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.35515022
31	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.32100324
32	Phototransduction_Homo sapiens_hsa04744	1.30962870
33	Morphine addiction_Homo sapiens_hsa05032	1.30947249
34	Olfactory transduction_Homo sapiens_hsa04740	1.30109098
35	Amphetamine addiction_Homo sapiens_hsa05031	1.25190554
36	Fatty acid degradation_Homo sapiens_hsa00071	1.23029183
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.22500976
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.21758222
39	Protein export_Homo sapiens_hsa03060	1.20639672
40	Serotonergic synapse_Homo sapiens_hsa04726	1.19481487
41	Bile secretion_Homo sapiens_hsa04976	1.19071813
42	Insulin secretion_Homo sapiens_hsa04911	1.18917721
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.18189701
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16763798
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16302786
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.15103786
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.13995449
48	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12005685
49	Mineral absorption_Homo sapiens_hsa04978	1.09813825
50	Oxidative phosphorylation_Homo sapiens_hsa00190	1.08770395
51	Circadian rhythm_Homo sapiens_hsa04710	1.06158787
52	Complement and coagulation cascades_Homo sapiens_hsa04610	1.02784386
53	Cocaine addiction_Homo sapiens_hsa05030	1.00698195
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.99112652
55	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97371810
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91530493
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.86999454
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.86955091
59	Parkinsons disease_Homo sapiens_hsa05012	0.86676656
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78892888
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.74705853
62	Sulfur relay system_Homo sapiens_hsa04122	0.70938560
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.70697001
64	Basal transcription factors_Homo sapiens_hsa03022	0.67233060
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.66223197
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.66135604
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65505292
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.65201572
69	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64655329
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.64207598
71	Renin secretion_Homo sapiens_hsa04924	0.62391352
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61354708
73	ABC transporters_Homo sapiens_hsa02010	0.59041341
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58578555
75	Long-term depression_Homo sapiens_hsa04730	0.57600037
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.56481312
77	Alzheimers disease_Homo sapiens_hsa05010	0.55020759
78	Homologous recombination_Homo sapiens_hsa03440	0.54960277
79	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.54617034
80	Metabolic pathways_Homo sapiens_hsa01100	0.54214616
81	Cholinergic synapse_Homo sapiens_hsa04725	0.53809683
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51687358
83	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.50481234
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45446329
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.45419185
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44225693
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.44135616
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.44029031
89	Gastric acid secretion_Homo sapiens_hsa04971	0.40506678
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39095044
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39072672
92	Oocyte meiosis_Homo sapiens_hsa04114	0.37766263
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37383690
94	Salivary secretion_Homo sapiens_hsa04970	0.36067827
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35705526
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32861886
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.31579356
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.30694845
99	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29285084
100	Caffeine metabolism_Homo sapiens_hsa00232	0.29283744

TRIM26BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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