TRIM27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)4.83231065
2DNA strand elongation involved in DNA replication (GO:0006271)4.79486583
3ribosomal small subunit assembly (GO:0000028)4.67568444
4DNA unwinding involved in DNA replication (GO:0006268)4.64615746
5spliceosomal tri-snRNP complex assembly (GO:0000244)4.60940729
6DNA strand elongation (GO:0022616)4.55631923
7DNA replication initiation (GO:0006270)4.55622824
8telomere maintenance via semi-conservative replication (GO:0032201)4.47516297
9DNA deamination (GO:0045006)4.40098656
10maturation of SSU-rRNA (GO:0030490)4.36508774
11viral transcription (GO:0019083)4.31395281
12translational termination (GO:0006415)4.25026214
13peptidyl-arginine omega-N-methylation (GO:0035247)4.24264002
14DNA topological change (GO:0006265)3.94743199
15DNA replication checkpoint (GO:0000076)3.93825935
16viral mRNA export from host cell nucleus (GO:0046784)3.92665821
17formation of translation preinitiation complex (GO:0001731)3.91588666
18telomere maintenance via recombination (GO:0000722)3.91107684
19translational elongation (GO:0006414)3.90323565
20histone arginine methylation (GO:0034969)3.83791417
21protein-DNA complex disassembly (GO:0032986)3.83619362
22nucleosome disassembly (GO:0006337)3.83619362
23protein localization to kinetochore (GO:0034501)3.83443209
24ribosomal large subunit biogenesis (GO:0042273)3.83375349
25folic acid-containing compound biosynthetic process (GO:0009396)3.83080444
26regulation of translational fidelity (GO:0006450)3.81995598
27DNA replication-dependent nucleosome organization (GO:0034723)3.76292910
28DNA replication-dependent nucleosome assembly (GO:0006335)3.76292910
29translational initiation (GO:0006413)3.75175948
30mitochondrial RNA metabolic process (GO:0000959)3.72294008
31peptidyl-arginine methylation (GO:0018216)3.71680827
32peptidyl-arginine N-methylation (GO:0035246)3.71680827
33nucleobase biosynthetic process (GO:0046112)3.70021774
34mitotic recombination (GO:0006312)3.69828083
35negative regulation of DNA-templated transcription, elongation (GO:0032785)3.67289538
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.66673066
37protein localization to chromosome, centromeric region (GO:0071459)3.66628759
38mitotic nuclear envelope disassembly (GO:0007077)3.66289931
39ribosomal small subunit biogenesis (GO:0042274)3.65484224
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61358089
41telomere maintenance via telomere lengthening (GO:0010833)3.60922511
42heterochromatin organization (GO:0070828)3.53372257
43ribonucleoprotein complex biogenesis (GO:0022613)3.52375815
44chromatin remodeling at centromere (GO:0031055)3.51303489
45regulation of mammary gland epithelial cell proliferation (GO:0033599)3.50431703
46protein targeting to ER (GO:0045047)3.50155464
47cotranslational protein targeting to membrane (GO:0006613)3.49834447
48mitotic metaphase plate congression (GO:0007080)3.48086641
49rRNA transcription (GO:0009303)3.46178559
50IMP biosynthetic process (GO:0006188)3.45891630
51CENP-A containing nucleosome assembly (GO:0034080)3.44523731
52pore complex assembly (GO:0046931)3.40413727
53nuclear envelope disassembly (GO:0051081)3.37912330
54membrane disassembly (GO:0030397)3.37912330
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.36916920
56ribosome biogenesis (GO:0042254)3.35618213
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35557691
58cellular protein complex disassembly (GO:0043624)3.35048265
59nuclear pore organization (GO:0006999)3.34335826
60purine nucleobase biosynthetic process (GO:0009113)3.32603095
61DNA replication-independent nucleosome assembly (GO:0006336)3.32269932
62DNA replication-independent nucleosome organization (GO:0034724)3.32269932
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31611190
64viral life cycle (GO:0019058)3.29615278
65protein localization to endoplasmic reticulum (GO:0070972)3.28691711
66nuclear pore complex assembly (GO:0051292)3.28668482
67rRNA processing (GO:0006364)3.27261841
68IMP metabolic process (GO:0046040)3.20880132
69translesion synthesis (GO:0019985)3.19717882
70negative regulation of mRNA processing (GO:0050686)3.18093082
71ribosome assembly (GO:0042255)3.18083197
72rRNA metabolic process (GO:0016072)3.17836684
73pseudouridine synthesis (GO:0001522)3.16916194
74spliceosomal snRNP assembly (GO:0000387)3.15031307
75protein complex disassembly (GO:0043241)3.14210056
76regulation of mitochondrial translation (GO:0070129)3.14123891
77COPI coating of Golgi vesicle (GO:0048205)3.14048226
78Golgi transport vesicle coating (GO:0048200)3.14048226
79negative regulation of mRNA metabolic process (GO:1903312)3.13650392
80DNA duplex unwinding (GO:0032508)3.13105799
81DNA geometric change (GO:0032392)3.11713052
82snRNA metabolic process (GO:0016073)3.09759827
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.09578400
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09578400
85metaphase plate congression (GO:0051310)3.08767486
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06991846
87positive regulation of B cell differentiation (GO:0045579)3.04560255
88snRNA processing (GO:0016180)3.04453213
89histone exchange (GO:0043486)3.03432167
90pre-miRNA processing (GO:0031054)3.03306964
91poly(A)+ mRNA export from nucleus (GO:0016973)3.01751888
92nuclear-transcribed mRNA catabolic process (GO:0000956)2.98342246
93folic acid metabolic process (GO:0046655)2.97987000
94mitotic sister chromatid segregation (GO:0000070)2.97466727
95regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.96260280
96macromolecular complex disassembly (GO:0032984)2.95575648
97negative regulation of RNA splicing (GO:0033119)2.94575243
98kinetochore organization (GO:0051383)2.93773731
99mitotic chromosome condensation (GO:0007076)2.93719778
100serine family amino acid biosynthetic process (GO:0009070)2.93139989
101L-serine metabolic process (GO:0006563)2.91495043
102negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88393367
103chromatin assembly or disassembly (GO:0006333)2.87356077
104RNA catabolic process (GO:0006401)2.86976153
105regulation of histone H3-K9 methylation (GO:0051570)2.86956259
106chromatin assembly (GO:0031497)2.86871903
107negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.86446444
108mRNA catabolic process (GO:0006402)2.84180218
109establishment of chromosome localization (GO:0051303)2.83002283
110translation (GO:0006412)2.81344166
111dosage compensation (GO:0007549)2.80660586
112mismatch repair (GO:0006298)2.80617128
113postreplication repair (GO:0006301)2.80376512
114establishment of integrated proviral latency (GO:0075713)2.79150622
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.78866807
116deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78805530
117proline biosynthetic process (GO:0006561)2.78566852
118base-excision repair (GO:0006284)2.77992570
119regulation of chromatin binding (GO:0035561)2.76229508
120GMP metabolic process (GO:0046037)2.76146936
121DNA strand renaturation (GO:0000733)2.76129757
122termination of RNA polymerase II transcription (GO:0006369)2.74975096
123telomere maintenance (GO:0000723)2.74552479
124sister chromatid segregation (GO:0000819)2.74105580
125telomere organization (GO:0032200)2.73986817
126tRNA methylation (GO:0030488)2.73680799
127mitochondrial DNA metabolic process (GO:0032042)2.72676156
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72443676
129mRNA export from nucleus (GO:0006406)2.72359159
130ATP-dependent chromatin remodeling (GO:0043044)2.71537738
131DNA conformation change (GO:0071103)2.71391528
132glutathione biosynthetic process (GO:0006750)2.71108506
133kinetochore assembly (GO:0051382)2.70030274
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69331479
135mRNA splicing, via spliceosome (GO:0000398)2.69004401
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.69004401
137RNA splicing, via transesterification reactions (GO:0000375)2.68648507
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67717157
139nuclear envelope organization (GO:0006998)2.67275779
140regulation of spindle organization (GO:0090224)2.65096401
141RNA export from nucleus (GO:0006405)2.64749050
142attachment of spindle microtubules to kinetochore (GO:0008608)2.64008083
143mRNA transport (GO:0051028)2.63968344
144protein K6-linked ubiquitination (GO:0085020)2.63409001
145protein localization to chromosome (GO:0034502)2.63081421
146pentose-phosphate shunt (GO:0006098)2.62782593
1473-UTR-mediated mRNA stabilization (GO:0070935)2.62605187
148regulation of helicase activity (GO:0051095)2.62575017
149mRNA stabilization (GO:0048255)2.61939181
150RNA stabilization (GO:0043489)2.61939181
151regulation of RNA export from nucleus (GO:0046831)2.61081164
152pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.59226377
153tRNA aminoacylation for protein translation (GO:0006418)2.57267411
154guanosine-containing compound biosynthetic process (GO:1901070)2.54554737
155retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54113329
156amino acid activation (GO:0043038)2.53869159
157tRNA aminoacylation (GO:0043039)2.53869159
158establishment of viral latency (GO:0019043)2.53032586
159intracellular estrogen receptor signaling pathway (GO:0030520)2.52180182
160pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.51494376
161mRNA cleavage (GO:0006379)2.50414134
162tRNA modification (GO:0006400)2.48295725
163regulation of histone H3-K4 methylation (GO:0051569)2.48069101
164leukotriene biosynthetic process (GO:0019370)2.47709188
165protein export from nucleus (GO:0006611)2.46523335
166mitochondrial fusion (GO:0008053)2.46462133
167positive regulation of cell cycle checkpoint (GO:1901978)2.46315100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.62219537
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.22014456
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.78374186
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72538568
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46304650
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.07109148
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91959757
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76344359
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71384145
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66172678
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.48623517
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.48119466
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46777964
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.44365060
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41582250
16XRN2_22483619_ChIP-Seq_HELA_Human2.29452956
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20511029
18MYC_22102868_ChIP-Seq_BL_Human2.15979633
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15472870
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13658583
21VDR_23849224_ChIP-Seq_CD4+_Human2.10736627
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.09310191
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.97331476
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96807597
25FOXP3_21729870_ChIP-Seq_TREG_Human1.95379192
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91891898
27* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89204803
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89180021
29DCP1A_22483619_ChIP-Seq_HELA_Human1.87111539
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86876515
31AR_21909140_ChIP-Seq_LNCAP_Human1.86873283
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86108686
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81765100
34* GABP_19822575_ChIP-Seq_HepG2_Human1.80944943
35TTF2_22483619_ChIP-Seq_HELA_Human1.79973319
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78877215
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77899883
38CIITA_25753668_ChIP-Seq_RAJI_Human1.70787263
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66600248
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63239395
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60119956
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57897907
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52645571
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49798325
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.49024457
46VDR_21846776_ChIP-Seq_THP-1_Human1.48918768
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48650429
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48333605
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48119371
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47130641
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46049847
52KDM5A_27292631_Chip-Seq_BREAST_Human1.45783680
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42939553
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40452407
55* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38843077
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38590043
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38438308
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37919047
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37241860
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.36588536
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33979487
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32354184
63NCOR1_26117541_ChIP-Seq_K562_Human1.31764579
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29747894
65ELK1_19687146_ChIP-ChIP_HELA_Human1.29629764
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29014538
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28635206
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28208079
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26912626
70MAF_26560356_Chip-Seq_TH2_Human1.26170888
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25653270
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24386867
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22980058
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21662281
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.20987780
76LXR_22292898_ChIP-Seq_THP-1_Human1.20958677
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17973545
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.17489829
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16792451
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16356600
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15514465
82RACK7_27058665_Chip-Seq_MCF-7_Human1.14433228
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12999404
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12697763
85P68_20966046_ChIP-Seq_HELA_Human1.12568079
86SPI1_23547873_ChIP-Seq_NB4_Human1.12252631
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12164450
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.11752534
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09582292
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.08689831
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08625361
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08483485
93* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07560840
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06906201
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.04543901
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04063774
97* TFEB_21752829_ChIP-Seq_HELA_Human1.03667732
98KDM2B_26808549_Chip-Seq_DND41_Human1.03310092
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03087477
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02574395
101VDR_24763502_ChIP-Seq_THP-1_Human1.02158329
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00281194
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99206081
104* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98472619
105PHF8_20622854_ChIP-Seq_HELA_Human0.97195431
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95949907
107MYC_18940864_ChIP-ChIP_HL60_Human0.94792023
108* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93075421
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92967448
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90565042
111UTX_26944678_Chip-Seq_JUKART_Human0.89170794
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88662414
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87738152
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86851058
115MAF_26560356_Chip-Seq_TH1_Human0.85874720
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84681030
117MYB_26560356_Chip-Seq_TH1_Human0.83027167
118MYB_26560356_Chip-Seq_TH2_Human0.82910081
119* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81814372
120SCL_19346495_ChIP-Seq_HPC-7_Human0.81727637
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80973233
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80528987
123* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79780780
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78913550
125* RUNX1_22412390_ChIP-Seq_EML_Mouse0.78858883
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78700275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.06947413
2MP0010094_abnormal_chromosome_stability4.29197185
3MP0003111_abnormal_nucleus_morphology4.11218903
4MP0004957_abnormal_blastocyst_morpholog3.96608643
5MP0003077_abnormal_cell_cycle3.62035271
6MP0008057_abnormal_DNA_replication3.49349446
7MP0008058_abnormal_DNA_repair3.12646923
8MP0002396_abnormal_hematopoietic_system2.75236761
9MP0005451_abnormal_body_composition2.69373160
10MP0008007_abnormal_cellular_replicative2.54540977
11MP0008260_abnormal_autophagy2.50581852
12MP0008995_early_reproductive_senescence2.38859214
13MP0000490_abnormal_crypts_of2.29700496
14MP0008932_abnormal_embryonic_tissue2.22457578
15MP0010352_gastrointestinal_tract_polyps2.19693928
16MP0004233_abnormal_muscle_weight2.14334251
17MP0000350_abnormal_cell_proliferation2.06649225
18MP0001730_embryonic_growth_arrest2.04796682
19MP0003123_paternal_imprinting1.98422238
20MP0006035_abnormal_mitochondrial_morpho1.92153899
21MP0008877_abnormal_DNA_methylation1.85428560
22MP0004808_abnormal_hematopoietic_stem1.81013552
23MP0003763_abnormal_thymus_physiology1.79359929
24MP0003786_premature_aging1.74762940
25MP0009333_abnormal_splenocyte_physiolog1.72736700
26MP0009697_abnormal_copulation1.61368403
27MP0010307_abnormal_tumor_latency1.60003539
28MP0001697_abnormal_embryo_size1.56668556
29MP0001672_abnormal_embryogenesis/_devel1.54901247
30MP0005380_embryogenesis_phenotype1.54901247
31MP0002019_abnormal_tumor_incidence1.52822519
32MP0000313_abnormal_cell_death1.51310670
33MP0002080_prenatal_lethality1.49827228
34MP0005397_hematopoietic_system_phenotyp1.47177035
35MP0001545_abnormal_hematopoietic_system1.47177035
36MP0002398_abnormal_bone_marrow1.46940609
37MP0003943_abnormal_hepatobiliary_system1.45694725
38MP0003567_abnormal_fetal_cardiomyocyte1.41991991
39MP0003984_embryonic_growth_retardation1.39230604
40MP0002085_abnormal_embryonic_tissue1.39229249
41MP0002210_abnormal_sex_determination1.37862270
42MP0000703_abnormal_thymus_morphology1.37802133
43MP0004858_abnormal_nervous_system1.37767187
44MP0002088_abnormal_embryonic_growth/wei1.36453972
45MP0001929_abnormal_gametogenesis1.34790303
46MP0002086_abnormal_extraembryonic_tissu1.32346068
47MP0002084_abnormal_developmental_patter1.30785928
48MP0002722_abnormal_immune_system1.29370295
49MP0005076_abnormal_cell_differentiation1.28949685
50MP0004197_abnormal_fetal_growth/weight/1.27794813
51MP0000678_abnormal_parathyroid_gland1.26161164
52MP0000537_abnormal_urethra_morphology1.25505602
53MP0006054_spinal_hemorrhage1.25439240
54MP0000689_abnormal_spleen_morphology1.25281809
55MP0002009_preneoplasia1.24828713
56MP0002249_abnormal_larynx_morphology1.24788289
57MP0001145_abnormal_male_reproductive1.23459964
58MP0003195_calcinosis1.17404478
59MP0003303_peritoneal_inflammation1.16702889
60MP0003121_genomic_imprinting1.16105165
61MP0001293_anophthalmia1.16020728
62MP0003385_abnormal_body_wall1.15987361
63MP0000858_altered_metastatic_potential1.14204958
64MP0002429_abnormal_blood_cell1.13466164
65MP0003656_abnormal_erythrocyte_physiolo1.11970889
66MP0009278_abnormal_bone_marrow1.07481094
67MP0000685_abnormal_immune_system1.07250275
68MP0005410_abnormal_fertilization1.05951127
69MP0000716_abnormal_immune_system1.05333282
70MP0000653_abnormal_sex_gland1.03443917
71MP0001800_abnormal_humoral_immune1.02482383
72MP0002697_abnormal_eye_size1.00569454
73MP0005058_abnormal_lysosome_morphology0.99629890
74MP0003315_abnormal_perineum_morphology0.98753554
75MP0003938_abnormal_ear_development0.98316078
76MP0001835_abnormal_antigen_presentation0.97476174
77MP0003718_maternal_effect0.97206848
78MP0002111_abnormal_tail_morphology0.96321072
79MP0002405_respiratory_system_inflammati0.95247351
80MP0006292_abnormal_olfactory_placode0.94981435
81MP0002420_abnormal_adaptive_immunity0.93674457
82MP0002877_abnormal_melanocyte_morpholog0.93321047
83MP0001873_stomach_inflammation0.92057147
84MP0001819_abnormal_immune_cell0.91969128
85MP0002452_abnormal_antigen_presenting0.91482017
86MP0005408_hypopigmentation0.90997515
87MP0006036_abnormal_mitochondrial_physio0.90354298
88MP0000477_abnormal_intestine_morphology0.89358343
89MP0000358_abnormal_cell_content/0.89134156
90MP0010155_abnormal_intestine_physiology0.88916749
91MP0003890_abnormal_embryonic-extraembry0.87770918
92MP0000465_gastrointestinal_hemorrhage0.87763270
93MP0005174_abnormal_tail_pigmentation0.87058790
94MP0002132_abnormal_respiratory_system0.86296225
95MP0009379_abnormal_foot_pigmentation0.86092614
96MP0004147_increased_porphyrin_level0.85104583
97MP0003119_abnormal_digestive_system0.84615159
98MP0002653_abnormal_ependyma_morphology0.84061122
99MP0002723_abnormal_immune_serum0.83139718
100MP0003115_abnormal_respiratory_system0.83026452
101MP0003698_abnormal_male_reproductive0.82010732
102MP0003937_abnormal_limbs/digits/tail_de0.81465594
103MP0002254_reproductive_system_inflammat0.81181660
104MP0005310_abnormal_salivary_gland0.78435753
105MP0000049_abnormal_middle_ear0.77892538
106MP0001881_abnormal_mammary_gland0.77672034
107MP0005075_abnormal_melanosome_morpholog0.77441036
108MP0005671_abnormal_response_to0.76777112
109MP0002160_abnormal_reproductive_system0.76622047
110MP0009785_altered_susceptibility_to0.76542526
111MP0000681_abnormal_thyroid_gland0.76435524
112MP0001119_abnormal_female_reproductive0.76237159
113MP0003436_decreased_susceptibility_to0.76045911
114MP0000598_abnormal_liver_morphology0.75974611
115MP0005384_cellular_phenotype0.75908503
116MP0005023_abnormal_wound_healing0.75627336
117MP0003191_abnormal_cellular_cholesterol0.74803484
118MP0001849_ear_inflammation0.73816032
119MP0005025_abnormal_response_to0.73656597
120MP0005645_abnormal_hypothalamus_physiol0.72917136
121MP0002822_catalepsy0.72819921
122MP0001853_heart_inflammation0.72645114
123MP0001915_intracranial_hemorrhage0.72603452
124MP0003942_abnormal_urinary_system0.72060553
125MP0003172_abnormal_lysosome_physiology0.71793574
126MP0005621_abnormal_cell_physiology0.71676840
127MP0002938_white_spotting0.71614094
128MP0004264_abnormal_extraembryonic_tissu0.71267673
129MP0002095_abnormal_skin_pigmentation0.71069127
130MP0003699_abnormal_female_reproductive0.70971355
131MP0002332_abnormal_exercise_endurance0.70318788
132MP0004133_heterotaxia0.67877893
133MP0009672_abnormal_birth_weight0.67766331
134MP0003221_abnormal_cardiomyocyte_apopto0.67353925
135MP0010030_abnormal_orbit_morphology0.67012711
136MP0005000_abnormal_immune_tolerance0.66570355
137MP0002166_altered_tumor_susceptibility0.66457152
138MP0009053_abnormal_anal_canal0.66355184
139MP0003566_abnormal_cell_adhesion0.64707692
140MP0002006_tumorigenesis0.62745385

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.90680921
2Microvesicular hepatic steatosis (HP:0001414)4.85569519
3Abnormality of cells of the erythroid lineage (HP:0012130)4.51790892
4Abnormal number of erythroid precursors (HP:0012131)4.40068071
5Birth length less than 3rd percentile (HP:0003561)4.14951971
6Aplastic anemia (HP:0001915)3.60424154
7Abnormality of the aortic arch (HP:0012303)3.46748755
8Colon cancer (HP:0003003)3.43161295
9Selective tooth agenesis (HP:0001592)3.36507495
10Oral leukoplakia (HP:0002745)3.33070938
11Chromsome breakage (HP:0040012)3.31237336
12Pallor (HP:0000980)3.20460450
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19599649
14Breast hypoplasia (HP:0003187)3.15139864
15Abnormality of the preputium (HP:0100587)3.13280447
16Abnormality of the anterior horn cell (HP:0006802)3.04544678
17Degeneration of anterior horn cells (HP:0002398)3.04544678
18Abnormality of chromosome stability (HP:0003220)3.03464071
19Meckel diverticulum (HP:0002245)3.02090681
20Absent thumb (HP:0009777)3.02002280
21Agnosia (HP:0010524)2.97730050
22Ependymoma (HP:0002888)2.97348901
23Macrocytic anemia (HP:0001972)2.95268033
24Thrombocytosis (HP:0001894)2.93823249
25Abnormality of the ileum (HP:0001549)2.90696496
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.89631944
27Homocystinuria (HP:0002156)2.87884419
28Abnormality of homocysteine metabolism (HP:0010919)2.87884419
29Ragged-red muscle fibers (HP:0003200)2.87039409
30Medulloblastoma (HP:0002885)2.82918287
3111 pairs of ribs (HP:0000878)2.82015422
32Myelodysplasia (HP:0002863)2.80435693
33Carpal bone hypoplasia (HP:0001498)2.68232893
34Patellar aplasia (HP:0006443)2.65466638
35Hyperacusis (HP:0010780)2.64345677
36Progressive external ophthalmoplegia (HP:0000590)2.62574627
37Basal cell carcinoma (HP:0002671)2.60426565
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.52395523
39Neoplasm of the pancreas (HP:0002894)2.48723980
40Aplasia/Hypoplasia of the patella (HP:0006498)2.47618021
41Microretrognathia (HP:0000308)2.46775732
42High anterior hairline (HP:0009890)2.45020822
43Rough bone trabeculation (HP:0100670)2.43490613
44Bone marrow hypocellularity (HP:0005528)2.41824524
45Trismus (HP:0000211)2.40862786
46Abnormal gallbladder physiology (HP:0012438)2.40501451
47Cholecystitis (HP:0001082)2.40501451
48Rhabdomyosarcoma (HP:0002859)2.40290855
49Small intestinal stenosis (HP:0012848)2.38346313
50Duodenal stenosis (HP:0100867)2.38346313
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37433659
52IgM deficiency (HP:0002850)2.26031709
53Cortical dysplasia (HP:0002539)2.25268526
54Ectopic kidney (HP:0000086)2.24814173
55Hypertensive crisis (HP:0100735)2.23991019
56Impulsivity (HP:0100710)2.23923089
57Lymphoma (HP:0002665)2.23257871
58Squamous cell carcinoma (HP:0002860)2.22456679
59Amaurosis fugax (HP:0100576)2.20075716
60Obstructive lung disease (HP:0006536)2.18624488
61Chronic obstructive pulmonary disease (HP:0006510)2.18624488
62Sloping forehead (HP:0000340)2.17975327
63Tracheoesophageal fistula (HP:0002575)2.17593447
64Premature graying of hair (HP:0002216)2.16071974
65Prominent nose (HP:0000448)2.15685294
66Triphalangeal thumb (HP:0001199)2.11515672
67Poikiloderma (HP:0001029)2.10553351
68Premature ovarian failure (HP:0008209)2.09587641
69Renal cell carcinoma (HP:0005584)2.09128791
70Cleft eyelid (HP:0000625)2.09105032
71Abnormality of the carotid arteries (HP:0005344)2.06966193
72Recurrent viral infections (HP:0004429)2.05486515
73Truncus arteriosus (HP:0001660)2.02600245
74Reduced antithrombin III activity (HP:0001976)2.02373574
75Recurrent abscess formation (HP:0002722)2.02067786
76Absent radius (HP:0003974)2.02018057
77Nasal polyposis (HP:0100582)2.01160217
78Pancytopenia (HP:0001876)2.01120438
79Slender long bone (HP:0003100)2.00563704
80Cellular immunodeficiency (HP:0005374)2.00322280
81Abnormality of reticulocytes (HP:0004312)2.00112433
82Abnormal number of incisors (HP:0011064)1.99690973
83Horseshoe kidney (HP:0000085)1.99127977
84Abnormality of DNA repair (HP:0003254)1.98906883
85Clubbing of toes (HP:0100760)1.97812578
86Coarctation of aorta (HP:0001680)1.97350961
87Abnormality of the duodenum (HP:0002246)1.97123276
88Supernumerary spleens (HP:0009799)1.95518673
89Type I transferrin isoform profile (HP:0003642)1.94907821
90Multiple enchondromatosis (HP:0005701)1.94789378
91High pitched voice (HP:0001620)1.93387875
92Abnormality of T cell physiology (HP:0011840)1.93133169
93Thoracic kyphosis (HP:0002942)1.92800141
94Recurrent bronchitis (HP:0002837)1.90783784
95Long palpebral fissure (HP:0000637)1.89322116
96Diastasis recti (HP:0001540)1.89063528
97Abnormality of the thoracic spine (HP:0100711)1.88534177
98Atresia of the external auditory canal (HP:0000413)1.88120931
99Missing ribs (HP:0000921)1.88044691
100Pelvic girdle muscle weakness (HP:0003749)1.87995607
101Reticulocytosis (HP:0001923)1.87832822
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86744755
103Absent forearm bone (HP:0003953)1.85752143
104Aplasia involving forearm bones (HP:0009822)1.85752143
105Peripheral hypomyelination (HP:0007182)1.85117732
106Abnormality of the parathyroid morphology (HP:0011766)1.84733943
107Abnormal spermatogenesis (HP:0008669)1.84382616
108Abnormality of T cells (HP:0002843)1.84182934
109Abnormality of pyrimidine metabolism (HP:0004353)1.84020398
110Cellulitis (HP:0100658)1.83902395
111Hypoplasia of the radius (HP:0002984)1.83438888
112Atrophy/Degeneration involving motor neurons (HP:0007373)1.81503766
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81103356
114Proximal placement of thumb (HP:0009623)1.80669795
115Recurrent fungal infections (HP:0002841)1.79702502
116Elfin facies (HP:0004428)1.79394056
117Short thumb (HP:0009778)1.79083765
118Increased serum ferritin (HP:0003281)1.78780324
119Increased nuchal translucency (HP:0010880)1.78299056
120Secondary amenorrhea (HP:0000869)1.78187189
121Neoplasm of striated muscle (HP:0009728)1.77981473
122Entropion (HP:0000621)1.77902638
123Eczematoid dermatitis (HP:0000976)1.77749958
124Biliary tract neoplasm (HP:0100574)1.77491252
125Personality changes (HP:0000751)1.75496418
126Septate vagina (HP:0001153)1.74734877
127Pulmonary fibrosis (HP:0002206)1.73762245
128Deviation of the thumb (HP:0009603)1.73674033
129Cafe-au-lait spot (HP:0000957)1.73669713
130Optic nerve coloboma (HP:0000588)1.73152506
131Colitis (HP:0002583)1.73103153
132Progressive muscle weakness (HP:0003323)1.72391348
133Shoulder girdle muscle weakness (HP:0003547)1.70918696
134Neoplasm of the colon (HP:0100273)1.70677681
135Facial hemangioma (HP:0000329)1.70374894
136Cerebral hypomyelination (HP:0006808)1.69648857
137Aplasia/Hypoplasia of the thymus (HP:0010515)1.69533262
138Overlapping toe (HP:0001845)1.69333320
139Duplicated collecting system (HP:0000081)1.69069067
140Broad distal phalanx of finger (HP:0009836)1.68960428
141Spina bifida occulta (HP:0003298)1.67221010
142Nephroblastoma (Wilms tumor) (HP:0002667)1.66126643
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65213691
144Recurrent bacterial skin infections (HP:0005406)1.64342247
145Loss of speech (HP:0002371)1.61787971
146Panhypogammaglobulinemia (HP:0003139)1.61727556
147Seborrheic dermatitis (HP:0001051)1.60987527
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59703271
149Absent epiphyses (HP:0010577)1.59703271
150Mediastinal lymphadenopathy (HP:0100721)1.56640712
151Abnormality of the intervertebral disk (HP:0005108)1.55053875
152Long foot (HP:0001833)1.52986664
153Disproportionate tall stature (HP:0001519)1.51335666
154Viral hepatitis (HP:0006562)1.51181738
155Persistence of primary teeth (HP:0006335)1.49573260
156Self-mutilation (HP:0000742)1.49492049
157Microglossia (HP:0000171)1.48822274
158Anteriorly placed anus (HP:0001545)1.47948025
159Orthostatic hypotension (HP:0001278)1.47876498
160Abnormality of the columella (HP:0009929)1.46581511
161Abnormality of the fingertips (HP:0001211)1.46268116
162Metaphyseal cupping (HP:0003021)1.46260734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.88679436
2WEE13.80825409
3BUB13.51121982
4ICK3.44486293
5NEK22.98911364
6EIF2AK12.86809999
7SMG12.83335975
8EEF2K2.63752620
9ACVR1B2.39860096
10NME22.28301360
11MAP3K102.18986238
12DYRK32.06363021
13PASK2.02947723
14TTK2.02593242
15IRAK32.02585076
16SRPK12.00126312
17EPHA31.99930345
18SCYL21.99220113
19EIF2AK31.97097016
20TLK11.93250710
21RPS6KB21.92459641
22MAP3K61.89966714
23MAP4K11.79569315
24TAOK21.76408690
25BRSK21.72661127
26PLK11.70411697
27CDK71.69225740
28RPS6KA41.69002262
29TSSK61.68621534
30STK101.65774306
31ATR1.63155124
32PLK41.62881995
33TESK21.61641414
34FLT31.59488445
35STK161.56827401
36CDK121.52358599
37PRPF4B1.52147999
38SIK21.49813493
39VRK11.47807495
40PKN21.47627392
41CDK41.46807909
42AURKB1.46626442
43CHEK21.38692799
44TGFBR11.36274990
45MAP3K81.34551437
46MKNK11.24877818
47TESK11.23621136
48BLK1.16442994
49VRK21.15424398
50FGFR41.14591124
51MATK1.13244609
52PRKD21.13164091
53AURKA1.11855320
54CHEK11.03216177
55RAF11.03089098
56EPHA21.02361679
57MAP3K111.00486774
58KDR0.99041250
59ZAP700.98511312
60PAK40.98491776
61PIM10.96634419
62CAMK1D0.96253313
63NME10.94895883
64MKNK20.94290857
65CDK80.90818701
66BTK0.90338133
67MAP3K50.90162680
68JAK30.87417878
69PLK30.86797385
70LRRK20.86677114
71TAOK10.85424295
72NEK10.84903630
73BRSK10.83324536
74NUAK10.82782113
75MAP2K70.82210759
76BCR0.81893130
77STK40.81652163
78PTK60.81284988
79MAP2K30.80222426
80ATM0.78526120
81MAPKAPK30.77543277
82DYRK1B0.76761914
83EIF2AK20.75501563
84PIM20.75444946
85RIPK40.74693798
86CCNB10.73151237
87MAP2K40.72391532
88CDK20.72088265
89BRD40.69649423
90GRK60.68005475
91TEC0.65453768
92PDK30.65369114
93PDK40.65369114
94PAK10.64356787
95CSNK2A20.61371853
96STK30.60775607
97CDK190.59846097
98KIT0.59175035
99TRIB30.58544620
100CSNK2A10.56170178
101ALK0.55759070
102SIK10.54732608
103CDK60.54672077
104CSF1R0.54458837
105DAPK10.53307072
106NLK0.52742065
107TAF10.52424573
108ERN10.50716377
109LATS10.50704709
110CLK10.48830699
111RET0.48402861
112KSR20.48248628
113IRAK40.45096926
114RPS6KC10.45036415
115RPS6KL10.45036415
116CSNK1G30.44807247
117MAPK110.44513332
118JAK20.43477658
119NEK90.42824651
120MTOR0.42682191
121TBK10.41727724
122CDK10.41689454
123MAP2K60.41662232
124MAP2K20.41541147
125ZAK0.41436999
126BMX0.41055234
127AKT10.38712957
128PRKCI0.38399797
129DYRK20.37747850
130CSNK1G10.37605059
131CSNK1A1L0.36101709
132MELK0.35654760
133RPS6KA50.34830687
134BCKDK0.34366429
135TYK20.32625994
136AKT20.32295894
137PAK20.31301151
138CDK90.30571249
139LYN0.29843468
140ILK0.29311484
141SYK0.29020231

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02740573
2Mismatch repair_Homo sapiens_hsa034304.14994610
3Ribosome_Homo sapiens_hsa030103.63092757
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23717580
5Spliceosome_Homo sapiens_hsa030403.13523473
6Base excision repair_Homo sapiens_hsa034103.09709101
7RNA transport_Homo sapiens_hsa030132.88712193
8Homologous recombination_Homo sapiens_hsa034402.86461185
9Nucleotide excision repair_Homo sapiens_hsa034202.67982777
10RNA polymerase_Homo sapiens_hsa030202.62909924
11One carbon pool by folate_Homo sapiens_hsa006702.55101278
12Cell cycle_Homo sapiens_hsa041102.53507678
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38423851
14Proteasome_Homo sapiens_hsa030502.38244672
15Pyrimidine metabolism_Homo sapiens_hsa002402.33210549
16Fanconi anemia pathway_Homo sapiens_hsa034602.28684493
17Non-homologous end-joining_Homo sapiens_hsa034502.00450843
18Basal transcription factors_Homo sapiens_hsa030221.75228516
19RNA degradation_Homo sapiens_hsa030181.72375211
20mRNA surveillance pathway_Homo sapiens_hsa030151.67885027
21p53 signaling pathway_Homo sapiens_hsa041151.57770989
22Sulfur relay system_Homo sapiens_hsa041221.47714529
23Antigen processing and presentation_Homo sapiens_hsa046121.38618739
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34816995
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33499347
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31549301
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29448144
28Systemic lupus erythematosus_Homo sapiens_hsa053221.28982573
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25419508
30Herpes simplex infection_Homo sapiens_hsa051681.19819238
31Purine metabolism_Homo sapiens_hsa002301.17598292
32Epstein-Barr virus infection_Homo sapiens_hsa051691.16373516
33Primary immunodeficiency_Homo sapiens_hsa053401.09948406
34Viral carcinogenesis_Homo sapiens_hsa052031.04784741
35Pentose phosphate pathway_Homo sapiens_hsa000300.98634009
36Selenocompound metabolism_Homo sapiens_hsa004500.98410227
37Lysine degradation_Homo sapiens_hsa003100.97379361
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93093442
39HTLV-I infection_Homo sapiens_hsa051660.87760936
40Legionellosis_Homo sapiens_hsa051340.85318966
41Folate biosynthesis_Homo sapiens_hsa007900.84934981
42Thyroid cancer_Homo sapiens_hsa052160.81702215
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78008496
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76639946
45Measles_Homo sapiens_hsa051620.76212486
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76196114
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75985946
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74904858
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.73792341
50Oocyte meiosis_Homo sapiens_hsa041140.71868023
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71747769
52Hepatitis C_Homo sapiens_hsa051600.71088238
53Protein export_Homo sapiens_hsa030600.70821683
54N-Glycan biosynthesis_Homo sapiens_hsa005100.70738499
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69924832
56Small cell lung cancer_Homo sapiens_hsa052220.69368678
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67377167
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67239072
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.65649042
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65418201
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64224467
62Apoptosis_Homo sapiens_hsa042100.62945610
63Acute myeloid leukemia_Homo sapiens_hsa052210.59672811
64Biosynthesis of amino acids_Homo sapiens_hsa012300.59535418
65Hepatitis B_Homo sapiens_hsa051610.58273299
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.57699189
67Shigellosis_Homo sapiens_hsa051310.55748995
68MicroRNAs in cancer_Homo sapiens_hsa052060.54945544
69Prolactin signaling pathway_Homo sapiens_hsa049170.54311097
70Inositol phosphate metabolism_Homo sapiens_hsa005620.52971115
71Colorectal cancer_Homo sapiens_hsa052100.52463392
72Endometrial cancer_Homo sapiens_hsa052130.52407815
73Chronic myeloid leukemia_Homo sapiens_hsa052200.52192170
74Influenza A_Homo sapiens_hsa051640.52036395
75VEGF signaling pathway_Homo sapiens_hsa043700.51527169
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.51415555
77Notch signaling pathway_Homo sapiens_hsa043300.49606286
78Steroid biosynthesis_Homo sapiens_hsa001000.49085194
79Hematopoietic cell lineage_Homo sapiens_hsa046400.47235476
80mTOR signaling pathway_Homo sapiens_hsa041500.46563448
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46240858
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45446742
83B cell receptor signaling pathway_Homo sapiens_hsa046620.44105310
84Osteoclast differentiation_Homo sapiens_hsa043800.43801134
85Alcoholism_Homo sapiens_hsa050340.43122543
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43061551
87Leishmaniasis_Homo sapiens_hsa051400.41977809
88Bladder cancer_Homo sapiens_hsa052190.41913819
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.40104140
90Vibrio cholerae infection_Homo sapiens_hsa051100.39356064
91Basal cell carcinoma_Homo sapiens_hsa052170.38592080
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38082632
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38056675
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36899900
95Glutathione metabolism_Homo sapiens_hsa004800.35419323
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.35082197
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34892514
98AMPK signaling pathway_Homo sapiens_hsa041520.34566898
99Vitamin B6 metabolism_Homo sapiens_hsa007500.34143501
100Salmonella infection_Homo sapiens_hsa051320.31701285
101Hippo signaling pathway_Homo sapiens_hsa043900.31164059
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30284626
103Insulin signaling pathway_Homo sapiens_hsa049100.30152735
104Metabolic pathways_Homo sapiens_hsa011000.30050003
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.29610109
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29521521
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.28612733
108HIF-1 signaling pathway_Homo sapiens_hsa040660.27539149
109Pathways in cancer_Homo sapiens_hsa052000.26838586
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26528286
111Pancreatic cancer_Homo sapiens_hsa052120.25923349
112TGF-beta signaling pathway_Homo sapiens_hsa043500.25583318
113T cell receptor signaling pathway_Homo sapiens_hsa046600.25113890
114Carbon metabolism_Homo sapiens_hsa012000.25054984
115Viral myocarditis_Homo sapiens_hsa054160.24403379
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24158088
117Galactose metabolism_Homo sapiens_hsa000520.24060609
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23312739
119Toxoplasmosis_Homo sapiens_hsa051450.22048941
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22012753
121Fructose and mannose metabolism_Homo sapiens_hsa000510.21919870
122Renin-angiotensin system_Homo sapiens_hsa046140.21794735
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18982732
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18272778
125Other glycan degradation_Homo sapiens_hsa005110.17850988
126Prostate cancer_Homo sapiens_hsa052150.17533570
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.17494309
128Non-small cell lung cancer_Homo sapiens_hsa052230.16819076

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