TRIM29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)7.81659128
2intermediate filament organization (GO:0045109)7.81468093
3peptide cross-linking (GO:0018149)7.44684051
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.43806716
5multicellular organismal water homeostasis (GO:0050891)7.40342576
6epidermis development (GO:0008544)6.32578795
7water homeostasis (GO:0030104)6.16616876
8epidermal cell differentiation (GO:0009913)6.04082765
9virion attachment to host cell (GO:0019062)5.72382789
10adhesion of symbiont to host cell (GO:0044650)5.72382789
11keratinocyte proliferation (GO:0043616)5.59979278
12skin morphogenesis (GO:0043589)5.16615331
13epithelial cell differentiation involved in prostate gland development (GO:0060742)4.99187731
14keratinocyte development (GO:0003334)4.94233009
15intermediate filament cytoskeleton organization (GO:0045104)4.78448034
16intermediate filament-based process (GO:0045103)4.63632052
17polarized epithelial cell differentiation (GO:0030859)4.63067533
18adhesion of symbiont to host (GO:0044406)4.61862644
19gap junction assembly (GO:0016264)4.43849897
20surfactant homeostasis (GO:0043129)4.40780155
21ectoderm development (GO:0007398)4.34134962
22negative regulation of keratinocyte proliferation (GO:0010839)4.33117555
23cell-substrate junction assembly (GO:0007044)4.26078986
24skin development (GO:0043588)3.83541274
25regulation of ruffle assembly (GO:1900027)3.81698997
26atrioventricular valve morphogenesis (GO:0003181)3.80401788
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.71760787
28hair follicle morphogenesis (GO:0031069)3.67127059
29negative regulation of cell fate specification (GO:0009996)3.66528216
30chemical homeostasis within a tissue (GO:0048875)3.56679147
31long-chain fatty acid biosynthetic process (GO:0042759)3.54535131
32axonemal dynein complex assembly (GO:0070286)3.51080553
33positive regulation of keratinocyte differentiation (GO:0045618)3.49064149
34regulation of hair follicle development (GO:0051797)3.44374960
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44322064
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.37429477
37hair cycle process (GO:0022405)3.37147541
38molting cycle process (GO:0022404)3.37147541
39sphingoid metabolic process (GO:0046519)3.37068501
40regulation of phospholipase A2 activity (GO:0032429)3.33806957
41interferon-gamma secretion (GO:0072643)3.26846646
42fatty acid elongation (GO:0030497)3.25606589
43cytoskeletal anchoring at plasma membrane (GO:0007016)3.20174128
44intestinal epithelial cell development (GO:0060576)3.18945385
45sphingosine metabolic process (GO:0006670)3.15492510
46epithelium development (GO:0060429)3.14385554
47establishment of tissue polarity (GO:0007164)3.07389467
48establishment of planar polarity (GO:0001736)3.07389467
49positive regulation of epidermis development (GO:0045684)3.05892790
50glucosamine-containing compound catabolic process (GO:1901072)3.05872075
51primary alcohol catabolic process (GO:0034310)3.03584272
52morphogenesis of embryonic epithelium (GO:0016331)3.00862482
53hypotonic response (GO:0006971)2.99582930
54one-carbon compound transport (GO:0019755)2.99194488
55cellular response to interferon-alpha (GO:0035457)2.98971451
56hair follicle development (GO:0001942)2.98617150
57regulation of hair cycle (GO:0042634)2.98205204
58negative regulation of cell fate commitment (GO:0010454)2.97398771
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.97207841
60positive regulation of hair cycle (GO:0042635)2.96726519
61positive regulation of hair follicle development (GO:0051798)2.96726519
62regulation of keratinocyte proliferation (GO:0010837)2.95856291
63gland morphogenesis (GO:0022612)2.95243726
64lateral sprouting from an epithelium (GO:0060601)2.92643608
65apical protein localization (GO:0045176)2.89146996
66mitotic G1 DNA damage checkpoint (GO:0031571)2.88347270
67ventricular cardiac muscle cell action potential (GO:0086005)2.87379711
68epithelial cell-cell adhesion (GO:0090136)2.86057011
69negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85162304
70diol metabolic process (GO:0034311)2.84677590
71detection of other organism (GO:0098543)2.81038777
72regulation of epidermis development (GO:0045682)2.80062607
73non-canonical Wnt signaling pathway (GO:0035567)2.79112906
74phosphatidylinositol acyl-chain remodeling (GO:0036149)2.78086031
75Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.75349627
76cardiac right ventricle morphogenesis (GO:0003215)2.73541644
77regulation of chemokine secretion (GO:0090196)2.72007355
78regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.70993506
79positive regulation of epidermal cell differentiation (GO:0045606)2.69925300
80positive regulation of interleukin-8 secretion (GO:2000484)2.69258694
81cell communication involved in cardiac conduction (GO:0086065)2.68661995
82regulation of establishment of planar polarity (GO:0090175)2.67457421
83eyelid development in camera-type eye (GO:0061029)2.65388337
84detection of bacterium (GO:0016045)2.64968730
85odontogenesis (GO:0042476)2.63917875
86regulation of cardioblast differentiation (GO:0051890)2.63472771
87odontogenesis of dentin-containing tooth (GO:0042475)2.63180013
88regulation of keratinocyte differentiation (GO:0045616)2.62168892
89establishment of apical/basal cell polarity (GO:0035089)2.61477107
90cell junction organization (GO:0034330)2.61416341
91motile cilium assembly (GO:0044458)2.60900200
92mitotic G1/S transition checkpoint (GO:0044819)2.60871333
93regulation of glomerular filtration (GO:0003093)2.60824368
94G1 DNA damage checkpoint (GO:0044783)2.59082833
95protein localization to endosome (GO:0036010)2.57990808
96regulation of cell proliferation involved in kidney development (GO:1901722)2.57659295
97cell junction assembly (GO:0034329)2.55407138
98asymmetric protein localization (GO:0008105)2.54452082
99phosphatidylserine metabolic process (GO:0006658)2.53976911
100negative regulation of stress fiber assembly (GO:0051497)2.52255471
101negative regulation of chondrocyte differentiation (GO:0032331)2.50718128
102cell-cell junction assembly (GO:0007043)2.48235381
103phosphatidylserine acyl-chain remodeling (GO:0036150)2.47605189
104lipoxygenase pathway (GO:0019372)2.47082329
105viral transcription (GO:0019083)2.46525322
106phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.46172759
107cilium or flagellum-dependent cell motility (GO:0001539)2.45709345
108regulation of transforming growth factor beta1 production (GO:0032908)2.45381762
109regulation of natural killer cell differentiation (GO:0032823)2.45156823
110cell surface receptor signaling pathway involved in heart development (GO:0061311)2.43573435
111plasma membrane repair (GO:0001778)2.42550298
112outer ear morphogenesis (GO:0042473)2.40674052
113heart valve morphogenesis (GO:0003179)2.40409584
114regulation of secondary heart field cardioblast proliferation (GO:0003266)2.40330223
115regulation of cardioblast proliferation (GO:0003264)2.40330223
116linoleic acid metabolic process (GO:0043651)2.39944984
117cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.37806058
118regulation of somitogenesis (GO:0014807)2.36114218
119G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.35757231
120regulation of transforming growth factor beta2 production (GO:0032909)2.35291257
121positive regulation of monocyte chemotaxis (GO:0090026)2.34127281
122negative regulation of interferon-gamma production (GO:0032689)2.32250497
123regulation of heart rate by cardiac conduction (GO:0086091)2.32174219
124regulation of epidermal cell differentiation (GO:0045604)2.31249505
125translational termination (GO:0006415)2.28419776
126collecting duct development (GO:0072044)2.26446988
127negative regulation of epidermis development (GO:0045683)2.26395342
128antigen processing and presentation of endogenous antigen (GO:0019883)2.25658475
129oocyte development (GO:0048599)2.24881999
130desmosome organization (GO:0002934)14.6129880
131molting cycle (GO:0042303)13.9402102
132hair cycle (GO:0042633)13.9402102
133keratinization (GO:0031424)13.8054793
134hemidesmosome assembly (GO:0031581)12.7282173
135establishment of skin barrier (GO:0061436)12.0314307
136regulation of water loss via skin (GO:0033561)10.9311140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.96791143
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.08149059
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.81415159
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.45307185
5ZNF263_19887448_ChIP-Seq_K562_Human2.33279817
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.29361828
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21152472
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.10213467
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00136361
10TP63_17297297_ChIP-ChIP_HaCaT_Human16.0576292
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99144403
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99144403
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.96116491
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.78171403
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73854184
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58473356
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53394761
18RACK7_27058665_Chip-Seq_MCF-7_Human1.37004651
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36310667
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35738928
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33197000
22SMC4_20622854_ChIP-Seq_HELA_Human1.31789536
23* TP63_22573176_ChIP-Seq_HFKS_Human1.31620614
24* TP63_23658742_ChIP-Seq_EP156T_Human1.30103026
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.29457145
26CJUN_26792858_Chip-Seq_BT549_Human1.29121595
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28397379
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.27323209
29KLF5_25053715_ChIP-Seq_YYC3_Human1.26549336
30* SOX2_20726797_ChIP-Seq_SW620_Human1.22547024
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22277482
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21932930
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21378049
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18498108
35UBF1/2_26484160_Chip-Seq_HMECs_Human1.15943160
36ATF3_27146783_Chip-Seq_COLON_Human1.15208144
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15014923
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14733682
39* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14419894
40RXR_22108803_ChIP-Seq_LS180_Human1.11787837
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.10164369
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09955308
43AHR_22903824_ChIP-Seq_MCF-7_Human1.06601755
44EGR1_19032775_ChIP-ChIP_M12_Human1.06289353
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04040783
46CTCF_27219007_Chip-Seq_Bcells_Human1.02860808
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.02634211
48P68_20966046_ChIP-Seq_HELA_Human1.00759783
49SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99756469
50ESR1_20079471_ChIP-ChIP_T-47D_Human0.97326192
51DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95837420
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95145861
53P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.94875595
54* LXR_22292898_ChIP-Seq_THP-1_Human0.94753789
55CREB1_26743006_Chip-Seq_LNCaP_Human0.94039766
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91045266
57* TP53_18474530_ChIP-ChIP_U2OS_Human0.90834465
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89444749
59SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89147061
60CLOCK_20551151_ChIP-Seq_293T_Human0.88041018
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87332471
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87049399
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87048790
64SA1_27219007_Chip-Seq_ERYTHROID_Human0.86810910
65GATA4_25053715_ChIP-Seq_YYC3_Human0.86785645
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86147997
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85753885
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85423326
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85225484
70JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85166812
71GATA6_25053715_ChIP-Seq_YYC3_Human0.85158851
72ARNT_22903824_ChIP-Seq_MCF-7_Human0.84721526
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84438358
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83984925
75* CTCF_20526341_ChIP-Seq_ESCs_Human0.83740753
76RNF2_27304074_Chip-Seq_ESCs_Mouse0.81646083
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.80266798
78TET1_21490601_ChIP-Seq_MESCs_Mouse0.80231949
79EZH2_27304074_Chip-Seq_ESCs_Mouse0.80030730
80PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79796726
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79384201
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78000194
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77965775
84CEBPB_22108803_ChIP-Seq_LS180_Human0.77643962
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76976826
86P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75746634
87PPARA_22158963_ChIP-Seq_LIVER_Mouse0.74979945
88CDX2_20551321_ChIP-Seq_CACO-2_Human0.74343826
89BCOR_27268052_Chip-Seq_Bcells_Human0.74312255
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73850661
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73564238
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.72991477
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.72658092
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.71990030
95EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71358807
96RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71358807
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70355457
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70181034
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70097283
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.69402690
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69283709
102TCF7_22412390_ChIP-Seq_EML_Mouse0.69119617
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.68746114
104TP53_22127205_ChIP-Seq_IMR90_Human0.68617622
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.68480271
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.68442859
107BCAT_22108803_ChIP-Seq_LS180_Human0.68014101
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67908453
109E2F1_20622854_ChIP-Seq_HELA_Human0.67812599
110* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67593201
111* KDM2B_26808549_Chip-Seq_K562_Human0.67158147
112CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65353004
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.65094756
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.64979231
115* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.64425170
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64227472
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.63885328
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.63732701
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.63732701
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.63094278
121NANOG_20526341_ChIP-Seq_ESCs_Human0.62172968
122* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.61878672
123MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.61801684
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61573810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.83256168
2MP0005275_abnormal_skin_tensile5.66945526
3MP0000579_abnormal_nail_morphology5.36973571
4MP0002254_reproductive_system_inflammat4.63316986
5MP0010234_abnormal_vibrissa_follicle4.57543937
6MP0005501_abnormal_skin_physiology4.16393593
7MP0000383_abnormal_hair_follicle3.86387310
8MP0002098_abnormal_vibrissa_morphology3.75857438
9MP0002060_abnormal_skin_morphology3.45360707
10MP0010678_abnormal_skin_adnexa3.39162750
11MP0003941_abnormal_skin_development3.38166644
12MP0001216_abnormal_epidermal_layer3.33419865
13MP0000647_abnormal_sebaceous_gland3.31083917
14MP0004381_abnormal_hair_follicle3.22724531
15MP0003705_abnormal_hypodermis_morpholog2.99769120
16MP0003453_abnormal_keratinocyte_physiol2.97407268
17MP0000467_abnormal_esophagus_morphology2.82722279
18MP0010771_integument_phenotype2.82688519
19MP0000377_abnormal_hair_follicle2.73984427
20MP0000427_abnormal_hair_cycle2.64284951
21MP0004947_skin_inflammation2.48487525
22MP0000762_abnormal_tongue_morphology2.35574873
23MP0001346_abnormal_lacrimal_gland2.11319971
24MP0002234_abnormal_pharynx_morphology2.04131425
25MP0003566_abnormal_cell_adhesion1.87405680
26MP0000566_synostosis1.75810497
27MP0009931_abnormal_skin_appearance1.70946073
28MP0001243_abnormal_dermal_layer1.61813166
29MP0001849_ear_inflammation1.57182470
30MP0001191_abnormal_skin_condition1.50384943
31MP0000367_abnormal_coat/_hair1.47492531
32MP0009379_abnormal_foot_pigmentation1.41149317
33MP0001851_eye_inflammation1.32500054
34MP0004185_abnormal_adipocyte_glucose1.32075324
35MP0003878_abnormal_ear_physiology1.31573430
36MP0005377_hearing/vestibular/ear_phenot1.31573430
37MP0010030_abnormal_orbit_morphology1.30123492
38MP0009780_abnormal_chondrocyte_physiolo1.29249750
39MP0004885_abnormal_endolymph1.21898930
40MP0005451_abnormal_body_composition1.18006080
41MP0009053_abnormal_anal_canal1.14022768
42MP0005023_abnormal_wound_healing1.05232097
43MP0005409_darkened_coat_color1.00628343
44MP0001340_abnormal_eyelid_morphology1.00144205
45MP0005367_renal/urinary_system_phenotyp0.99641881
46MP0000516_abnormal_urinary_system0.99641881
47MP0002009_preneoplasia0.94084138
48MP0002095_abnormal_skin_pigmentation0.89103185
49MP0002877_abnormal_melanocyte_morpholog0.84213339
50MP0003191_abnormal_cellular_cholesterol0.83953628
51MP0008789_abnormal_olfactory_epithelium0.79894092
52MP0002177_abnormal_outer_ear0.79779439
53MP0003755_abnormal_palate_morphology0.78862272
54MP0000538_abnormal_urinary_bladder0.76308334
55MP0000627_abnormal_mammary_gland0.74732255
56MP0004272_abnormal_basement_membrane0.73269466
57MP0008438_abnormal_cutaneous_collagen0.70966807
58MP0002249_abnormal_larynx_morphology0.68772833
59MP0010352_gastrointestinal_tract_polyps0.68744596
60MP0005075_abnormal_melanosome_morpholog0.68701639
61MP0000537_abnormal_urethra_morphology0.68583153
62MP0000465_gastrointestinal_hemorrhage0.68377947
63MP0005076_abnormal_cell_differentiation0.68030064
64MP0003011_delayed_dark_adaptation0.65709345
65MP0002282_abnormal_trachea_morphology0.62546012
66MP0002111_abnormal_tail_morphology0.60340687
67MP0005257_abnormal_intraocular_pressure0.59776070
68MP0004043_abnormal_pH_regulation0.59057227
69MP0002233_abnormal_nose_morphology0.57993081
70MP0000678_abnormal_parathyroid_gland0.56744256
71MP0008260_abnormal_autophagy0.54465103
72MP0001784_abnormal_fluid_regulation0.53955902
73MP0004782_abnormal_surfactant_physiolog0.52492809
74MP0000015_abnormal_ear_pigmentation0.51893746
75MP0003763_abnormal_thymus_physiology0.51535864
76MP0005508_abnormal_skeleton_morphology0.51490868
77MP0000613_abnormal_salivary_gland0.50445786
78MP0000858_altered_metastatic_potential0.49187727
79MP0003315_abnormal_perineum_morphology0.48938866
80MP0003385_abnormal_body_wall0.48654834
81MP0002006_tumorigenesis0.48051492
82MP0009250_abnormal_appendicular_skeleto0.46699288
83MP0002166_altered_tumor_susceptibility0.45542832
84MP0005394_taste/olfaction_phenotype0.45359106
85MP0005499_abnormal_olfactory_system0.45359106
86MP0004264_abnormal_extraembryonic_tissu0.43188436
87MP0000733_abnormal_muscle_development0.42714063
88MP0001188_hyperpigmentation0.41858512
89MP0003045_fibrosis0.41715991
90MP0004858_abnormal_nervous_system0.41256715
91MP0001958_emphysema0.40738619
92MP0009384_cardiac_valve_regurgitation0.40512244
93MP0003950_abnormal_plasma_membrane0.39733374
94MP0000432_abnormal_head_morphology0.39725890
95MP0006138_congestive_heart_failure0.36161045
96MP0006054_spinal_hemorrhage0.35422269
97MP0000470_abnormal_stomach_morphology0.35140145
98MP0001984_abnormal_olfaction0.34258993
99MP0005666_abnormal_adipose_tissue0.32703646
100MP0002109_abnormal_limb_morphology0.31395418
101MP0001299_abnormal_eye_distance/0.31360063
102MP0005503_abnormal_tendon_morphology0.31256135
103MP0008961_abnormal_basal_metabolism0.31164714
104MP0002896_abnormal_bone_mineralization0.30706913
105MP0001765_abnormal_ion_homeostasis0.30677954
106MP0000003_abnormal_adipose_tissue0.30651873
107MP0005193_abnormal_anterior_eye0.29683595
108MP0003436_decreased_susceptibility_to0.29305566
109MP0003935_abnormal_craniofacial_develop0.29022998
110MP0004019_abnormal_vitamin_homeostasis0.28930542
111MP0003300_gastrointestinal_ulcer0.28059995
112MP0000428_abnormal_craniofacial_morphol0.27679833
113MP0003091_abnormal_cell_migration0.27670908
114MP0005390_skeleton_phenotype0.27188099
115MP0005174_abnormal_tail_pigmentation0.27092590
116MP0005248_abnormal_Harderian_gland0.26534415
117MP0000685_abnormal_immune_system0.25459955
118MP0002697_abnormal_eye_size0.25456504
119MP0003638_abnormal_response/metabolism_0.25161973
120MP0002133_abnormal_respiratory_system0.25035075
121MP0005388_respiratory_system_phenotype0.25035075
122MP0001270_distended_abdomen0.24918928
123MP0003448_altered_tumor_morphology0.24536614
124MP0005375_adipose_tissue_phenotype0.24360278
125MP0004197_abnormal_fetal_growth/weight/0.21956927

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.55183623
2Plantar hyperkeratosis (HP:0007556)7.64738653
3Onycholysis (HP:0001806)7.35108847
4Milia (HP:0001056)7.32405987
5Fragile nails (HP:0001808)7.24872511
6Woolly hair (HP:0002224)7.00452068
7Palmoplantar hyperkeratosis (HP:0000972)6.66464341
8Pili torti (HP:0003777)6.34465527
9Palmar hyperkeratosis (HP:0010765)6.28282170
10Abnormality of nail color (HP:0100643)6.26412943
11Increased IgE level (HP:0003212)6.15813863
12Thick nail (HP:0001805)5.98240714
13Right ventricular cardiomyopathy (HP:0011663)5.93599884
14Nail dystrophy (HP:0008404)5.27288690
15Atrophic scars (HP:0001075)4.87814689
16Abnormal blistering of the skin (HP:0008066)4.51492460
17Erythema (HP:0010783)4.41284832
18Conjunctival hamartoma (HP:0100780)4.30193490
19Alopecia of scalp (HP:0002293)4.26653375
20Congenital ichthyosiform erythroderma (HP:0007431)4.24846654
21Erythroderma (HP:0001019)4.13943256
22Lip pit (HP:0100267)4.11629711
23Abnormal hair laboratory examination (HP:0003328)3.95975415
24Ridged nail (HP:0001807)3.62670741
25Parakeratosis (HP:0001036)3.57599400
26Natal tooth (HP:0000695)3.44030151
27Sparse eyelashes (HP:0000653)3.34502779
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.32125562
29Advanced eruption of teeth (HP:0006288)3.18064184
30Aplasia cutis congenita (HP:0001057)3.10441449
31Follicular hyperkeratosis (HP:0007502)3.08739555
32Ectropion (HP:0000656)3.08230175
33Corneal erosion (HP:0200020)2.91847860
34Fragile skin (HP:0001030)2.89721135
35Palmoplantar keratoderma (HP:0000982)2.88852947
36Abnormality of the neuromuscular junction (HP:0003398)2.86463835
37Fatigable weakness (HP:0003473)2.86463835
38Brittle hair (HP:0002299)2.79456905
39Sparse scalp hair (HP:0002209)2.77803033
40Ventricular tachycardia (HP:0004756)2.74406396
41Gangrene (HP:0100758)2.72421808
42Hypohidrosis (HP:0000966)2.69890289
43Hamartoma of the eye (HP:0010568)2.68610509
44Curly hair (HP:0002212)2.66394367
45Abnormality of hair growth rate (HP:0011363)2.58169666
46Slow-growing hair (HP:0002217)2.58169666
47Absent hair (HP:0002298)2.50194724
48Hyporeflexia of lower limbs (HP:0002600)2.48467358
49Distal lower limb muscle weakness (HP:0009053)2.44713172
50Increased connective tissue (HP:0009025)2.41694323
51Amelogenesis imperfecta (HP:0000705)2.40752864
52Pruritus (HP:0000989)2.39561507
53Acanthosis nigricans (HP:0000956)2.37120679
54Hypoplasia of dental enamel (HP:0006297)2.28009402
55Abnormality of permanent molar morphology (HP:0011071)2.26317257
56Abnormality of the dental root (HP:0006486)2.26317257
57Taurodontia (HP:0000679)2.26317257
58Pterygium (HP:0001059)2.22581408
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22023481
60Abnormality of secondary sexual hair (HP:0009888)2.21743685
61Abnormality of the axillary hair (HP:0100134)2.21743685
62Type 1 muscle fiber predominance (HP:0003803)2.20437877
63Blepharitis (HP:0000498)2.16172769
64Oral leukoplakia (HP:0002745)2.16131116
65Abnormality of placental membranes (HP:0011409)2.13802453
66Amniotic constriction ring (HP:0009775)2.13802453
67Abnormality of molar (HP:0011077)2.13446142
68Abnormality of molar morphology (HP:0011070)2.13446142
69Anonychia (HP:0001798)2.13229847
70Chronic bronchitis (HP:0004469)2.13094242
71Hyperhidrosis (HP:0000975)2.09160637
72Duplicated collecting system (HP:0000081)2.02328294
73Esophageal atresia (HP:0002032)2.00638889
74Abnormality of the dental pulp (HP:0006479)1.98070908
75Popliteal pterygium (HP:0009756)1.97084549
76Abnormality of the gastric mucosa (HP:0004295)1.95806099
77Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94876018
78Xerostomia (HP:0000217)1.91673290
79Ankyloglossia (HP:0010296)1.90797162
80Skin ulcer (HP:0200042)1.89644546
81Eczematoid dermatitis (HP:0000976)1.88845251
82Congenital, generalized hypertrichosis (HP:0004540)1.88109595
83Septate vagina (HP:0001153)1.87660540
84Round ear (HP:0100830)1.86271582
85Hypergammaglobulinemia (HP:0010702)1.84909957
86Furrowed tongue (HP:0000221)1.84452443
87Down-sloping shoulders (HP:0200021)1.84300566
88Skin pits (HP:0100276)1.83776715
89Carious teeth (HP:0000670)1.82985013
90Split foot (HP:0001839)1.82598645
91Labial hypoplasia (HP:0000066)1.82332585
92Hypoplastic labia majora (HP:0000059)1.81964476
93Ventricular fibrillation (HP:0001663)1.81717721
94Nasolacrimal duct obstruction (HP:0000579)1.80193841
95Abnormality of the fingernails (HP:0001231)1.79037770
96Laryngomalacia (HP:0001601)1.78908695
97Nasal polyposis (HP:0100582)1.77412224
98Abnormal respiratory motile cilium physiology (HP:0012261)1.74915442
99Conical tooth (HP:0000698)1.73032374
100Melanocytic nevus (HP:0000995)1.70990121
101Hypodontia (HP:0000668)1.70043967
102Multifactorial inheritance (HP:0001426)1.69808559
103Abnormality of the renal collecting system (HP:0004742)1.69357498
104Concave nail (HP:0001598)1.68773632
105Hypoplastic female external genitalia (HP:0012815)1.67851392
106Abnormal respiratory epithelium morphology (HP:0012253)1.67726692
107Abnormal respiratory motile cilium morphology (HP:0005938)1.67726692
108Neonatal death (HP:0003811)1.65983451
109Abnormality of the labia majora (HP:0012881)1.62640238
110Aplasia involving bones of the extremities (HP:0009825)1.62047075
111Aplasia involving bones of the upper limbs (HP:0009823)1.62047075
112Aplasia of the phalanges of the hand (HP:0009802)1.62047075
113Corneal dystrophy (HP:0001131)1.61300102
114Abnormality of the salivary glands (HP:0010286)1.60009952
115Dry hair (HP:0011359)1.59618799
116Abnormality of the lacrimal duct (HP:0011481)1.59342473
117Oligodontia (HP:0000677)1.57850506
118Premature loss of primary teeth (HP:0006323)1.57638807
119Distal arthrogryposis (HP:0005684)1.55503472
120Lack of skin elasticity (HP:0100679)1.55317989
121Abnormality of the distal phalanges of the toes (HP:0010182)1.54966071
122Dehydration (HP:0001944)1.54896604
123Myopathic facies (HP:0002058)1.53770064
124Scapular winging (HP:0003691)1.52369379
125Achilles tendon contracture (HP:0001771)1.52266603
126Absent eyelashes (HP:0000561)1.50223977
127Fine hair (HP:0002213)1.48457717
128Unilateral renal agenesis (HP:0000122)1.48091580
129Selective tooth agenesis (HP:0001592)1.47468268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.30905637
2MAPKAPK34.23782091
3MST1R4.05948863
4FER3.73751024
5ERN13.23810578
6MAP3K22.96182881
7LATS12.80401596
8EPHB22.71408871
9RPS6KB22.43097475
10TTN2.28626052
11PIK3CG2.18778233
12EPHA22.18670163
13MST42.15706422
14EPHA31.99380599
15FGFR21.95427068
16SMG11.94215596
17MAPK151.89324165
18EPHB11.88133644
19EEF2K1.74994744
20FGFR41.73573168
21TRPM71.68022179
22TRIB31.64244721
23TAOK11.63951668
24RIPK11.55741180
25CDK121.45399397
26MET1.44034811
27FGFR11.40571242
28RPS6KA41.39822073
29NTRK11.31631739
30LRRK21.31102272
31MAPKAPK51.31065643
32LMTK21.30617357
33FGFR31.29422190
34TYK21.29314451
35STK241.29104956
36PTK61.24958129
37MAP3K111.21042717
38NME11.16843375
39MAP3K11.14655277
40ERBB31.14642550
41MAP2K61.10992270
42BCR1.06947099
43SIK11.06044231
44OBSCN1.05959056
45ICK1.04737270
46PAK41.02715060
47STK380.99647656
48ARAF0.99046297
49CDK60.96384007
50PIM20.94226261
51PTK20.93826243
52TGFBR20.92192220
53DYRK1B0.91880149
54PRPF4B0.90345718
55MAP3K70.89641241
56MARK20.83339583
57BLK0.83111997
58LATS20.81728928
59MAP2K20.81057947
60PRKD20.78224432
61MTOR0.75890518
62ERBB20.74919642
63PBK0.74873242
64MAP2K30.74392572
65NTRK20.73792642
66DMPK0.73177918
67NEK60.71923194
68STK100.69689597
69MAP3K140.69659259
70NME20.69497425
71MAP2K10.68851010
72CDC42BPA0.66968026
73MAP3K60.66950602
74CDK30.63278916
75MAP3K90.63099632
76TESK10.62721388
77FLT30.62146357
78PRKD10.61736804
79RPS6KA10.61307764
80BMX0.60712738
81PDGFRB0.57058599
82IRAK30.55404353
83IKBKE0.55105152
84STK30.51360057
85ITK0.50046513
86JAK10.49099590
87HIPK20.47436634
88DDR20.47108176
89MAP3K120.46727096
90ILK0.46700208
91TGFBR10.45249704
92GRK60.43672537
93JAK20.43089327
94STK38L0.42028686
95NLK0.41960371
96PRKCI0.41731253
97KSR20.40789948
98GSK3A0.40603737
99WNK10.40590203
100RPS6KB10.38864364
101RPS6KA20.38316183
102PDGFRA0.37539369
103PAK20.37304322
104MAP3K100.34500687
105CSK0.33914897
106PRKAA20.33051052
107PKN20.33023357
108SGK4940.32954952
109SGK2230.32954952
110MAPK120.32660021
111RPS6KC10.31133619
112RPS6KL10.31133619
113CHUK0.30393602
114* MAPKAPK20.30122496
115MAP3K130.30109973
116IRAK10.29221719
117MAPK110.27478829
118BMPR1B0.27459212
119TBK10.27191439
120SGK30.27086052
121TYRO30.27045424
122RET0.26701153
123ROCK20.25172074
124RPS6KA60.24673742
125HCK0.24568680
126BTK0.24517113
127MAPK70.24313915
128ROCK10.24192148
129ABL20.23243252
130FRK0.22813750
131IKBKB0.22716408
132JAK30.21803143
133MYLK0.19443922
134PRKCD0.16083109

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004602.84537859
2Basal cell carcinoma_Homo sapiens_hsa052172.69218203
3Linoleic acid metabolism_Homo sapiens_hsa005912.69012174
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.65653016
5ECM-receptor interaction_Homo sapiens_hsa045122.53310703
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31457493
7Arachidonic acid metabolism_Homo sapiens_hsa005902.04133825
8Sphingolipid metabolism_Homo sapiens_hsa006001.89129636
9Phenylalanine metabolism_Homo sapiens_hsa003601.88337476
10Fatty acid elongation_Homo sapiens_hsa000621.87167423
11Hedgehog signaling pathway_Homo sapiens_hsa043401.81048459
12Hippo signaling pathway_Homo sapiens_hsa043901.73882805
13Amoebiasis_Homo sapiens_hsa051461.67117261
14Ribosome_Homo sapiens_hsa030101.65977112
15Proteoglycans in cancer_Homo sapiens_hsa052051.64371105
16Adherens junction_Homo sapiens_hsa045201.64198695
17Toxoplasmosis_Homo sapiens_hsa051451.62033677
18Histidine metabolism_Homo sapiens_hsa003401.54949034
19VEGF signaling pathway_Homo sapiens_hsa043701.49192284
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42768713
21Bladder cancer_Homo sapiens_hsa052191.41999633
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38369758
23Ether lipid metabolism_Homo sapiens_hsa005651.36630750
24Notch signaling pathway_Homo sapiens_hsa043301.36157829
25Melanogenesis_Homo sapiens_hsa049161.35844288
26Tight junction_Homo sapiens_hsa045301.33837016
27Axon guidance_Homo sapiens_hsa043601.32072795
28Small cell lung cancer_Homo sapiens_hsa052221.29059104
29Ovarian steroidogenesis_Homo sapiens_hsa049131.26877632
30Circadian rhythm_Homo sapiens_hsa047101.26839611
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.21529325
32Caffeine metabolism_Homo sapiens_hsa002321.18687004
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18199607
34Focal adhesion_Homo sapiens_hsa045101.16743845
35GnRH signaling pathway_Homo sapiens_hsa049121.15790600
36Choline metabolism in cancer_Homo sapiens_hsa052311.15203584
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12613889
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11972650
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10701165
40Protein digestion and absorption_Homo sapiens_hsa049741.09577124
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.07929811
42Fatty acid biosynthesis_Homo sapiens_hsa000611.07228817
43Acute myeloid leukemia_Homo sapiens_hsa052211.07057729
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06996608
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04611276
46Thyroid cancer_Homo sapiens_hsa052161.03699535
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.00337965
48Staphylococcus aureus infection_Homo sapiens_hsa051500.95817706
49Chemical carcinogenesis_Homo sapiens_hsa052040.95029372
50Fat digestion and absorption_Homo sapiens_hsa049750.94939655
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93962657
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92546074
53Pertussis_Homo sapiens_hsa051330.91136654
54TNF signaling pathway_Homo sapiens_hsa046680.90966471
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.90796128
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90449964
57MicroRNAs in cancer_Homo sapiens_hsa052060.90048842
58Tyrosine metabolism_Homo sapiens_hsa003500.89503856
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.88865282
60TGF-beta signaling pathway_Homo sapiens_hsa043500.88623693
61Insulin signaling pathway_Homo sapiens_hsa049100.87409917
62p53 signaling pathway_Homo sapiens_hsa041150.87081825
63Hepatitis C_Homo sapiens_hsa051600.85725391
64Retinol metabolism_Homo sapiens_hsa008300.84553790
65Endocytosis_Homo sapiens_hsa041440.84276169
66Pancreatic cancer_Homo sapiens_hsa052120.84146751
67Wnt signaling pathway_Homo sapiens_hsa043100.84077675
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83997100
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83430581
70Inositol phosphate metabolism_Homo sapiens_hsa005620.83137605
71Antigen processing and presentation_Homo sapiens_hsa046120.81527108
72Pathways in cancer_Homo sapiens_hsa052000.80237474
73Dorso-ventral axis formation_Homo sapiens_hsa043200.78235292
74Chronic myeloid leukemia_Homo sapiens_hsa052200.76883015
75Endometrial cancer_Homo sapiens_hsa052130.76715776
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76443575
77Insulin resistance_Homo sapiens_hsa049310.76332616
78Pancreatic secretion_Homo sapiens_hsa049720.74576220
79Arginine biosynthesis_Homo sapiens_hsa002200.74184396
80Estrogen signaling pathway_Homo sapiens_hsa049150.74129587
81Osteoclast differentiation_Homo sapiens_hsa043800.73043101
82Ras signaling pathway_Homo sapiens_hsa040140.71422764
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70379804
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70037456
85Renin secretion_Homo sapiens_hsa049240.69993741
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69409951
87Platelet activation_Homo sapiens_hsa046110.68708492
88Rap1 signaling pathway_Homo sapiens_hsa040150.68232998
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.67733444
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.66583365
91Gastric acid secretion_Homo sapiens_hsa049710.65967713
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63902165
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62542878
94Apoptosis_Homo sapiens_hsa042100.62455219
95Salivary secretion_Homo sapiens_hsa049700.62344079
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.62101637
97Prolactin signaling pathway_Homo sapiens_hsa049170.61282379
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61162670
99Tuberculosis_Homo sapiens_hsa051520.60817003
100PPAR signaling pathway_Homo sapiens_hsa033200.59681227
101Influenza A_Homo sapiens_hsa051640.59571900
102Leishmaniasis_Homo sapiens_hsa051400.59396297
103Dilated cardiomyopathy_Homo sapiens_hsa054140.58264962
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57847904
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57399984
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57298546
107Phototransduction_Homo sapiens_hsa047440.55862522
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.55358581
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55289897
110Glioma_Homo sapiens_hsa052140.55180993
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54925246
112Melanoma_Homo sapiens_hsa052180.53458739
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51630327
114Salmonella infection_Homo sapiens_hsa051320.51181246
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50739105
116Malaria_Homo sapiens_hsa051440.49842267
117ErbB signaling pathway_Homo sapiens_hsa040120.49775592
118HTLV-I infection_Homo sapiens_hsa051660.48886257
119beta-Alanine metabolism_Homo sapiens_hsa004100.48830213
120Long-term depression_Homo sapiens_hsa047300.48580399
121Prostate cancer_Homo sapiens_hsa052150.47428421
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46187958
123Steroid biosynthesis_Homo sapiens_hsa001000.45387334
124ABC transporters_Homo sapiens_hsa020100.43980150
125Renal cell carcinoma_Homo sapiens_hsa052110.43617008
126Non-small cell lung cancer_Homo sapiens_hsa052230.43577031
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43471075
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.42288616
129Glucagon signaling pathway_Homo sapiens_hsa049220.41656396
130Glycerolipid metabolism_Homo sapiens_hsa005610.40536027
131Vitamin digestion and absorption_Homo sapiens_hsa049770.38718645

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