TRIM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.48618720
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38667217
3locomotory exploration behavior (GO:0035641)5.16286713
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03119554
5synaptic vesicle exocytosis (GO:0016079)4.81209001
6vocalization behavior (GO:0071625)4.73717089
7glutamate secretion (GO:0014047)4.72587113
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59110544
9regulation of synaptic vesicle exocytosis (GO:2000300)4.44417033
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39821042
11neuronal action potential propagation (GO:0019227)4.36893560
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.30346101
13layer formation in cerebral cortex (GO:0021819)4.10577320
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.09687518
15neurotransmitter secretion (GO:0007269)4.01363482
16regulation of glutamate receptor signaling pathway (GO:1900449)3.96234242
17regulation of synaptic vesicle transport (GO:1902803)3.87956009
18protein localization to synapse (GO:0035418)3.85103775
19exploration behavior (GO:0035640)3.77201630
20cerebellar granule cell differentiation (GO:0021707)3.76754419
21cellular potassium ion homeostasis (GO:0030007)3.75417933
22neuron cell-cell adhesion (GO:0007158)3.74561028
23synaptic transmission, glutamatergic (GO:0035249)3.71160277
24glutamate receptor signaling pathway (GO:0007215)3.70317882
25gamma-aminobutyric acid transport (GO:0015812)3.70018276
26regulation of neuronal synaptic plasticity (GO:0048168)3.64734919
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.63759605
28dendritic spine morphogenesis (GO:0060997)3.60388123
29long-term memory (GO:0007616)3.59242865
30sodium ion export (GO:0071436)3.58987964
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56049668
32cerebellar Purkinje cell differentiation (GO:0021702)3.55020171
33activation of protein kinase A activity (GO:0034199)3.51769276
34regulation of synapse structural plasticity (GO:0051823)3.46580043
35dendrite morphogenesis (GO:0048813)3.41081237
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39626999
37neuron-neuron synaptic transmission (GO:0007270)3.39344607
38positive regulation of synapse maturation (GO:0090129)3.29895942
39synaptic vesicle endocytosis (GO:0048488)3.29622719
40neurotransmitter-gated ion channel clustering (GO:0072578)3.28957792
41proline transport (GO:0015824)3.27963077
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27508485
43cell communication by electrical coupling (GO:0010644)3.26000652
44neuron recognition (GO:0008038)3.25664015
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24102645
46glycine transport (GO:0015816)3.23468956
47neuromuscular process controlling balance (GO:0050885)3.23185426
48neurotransmitter transport (GO:0006836)3.22202356
49response to pheromone (GO:0019236)3.21606307
50regulation of female receptivity (GO:0045924)3.17757360
51transmission of nerve impulse (GO:0019226)3.16551638
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15039516
53axonal fasciculation (GO:0007413)3.13338288
54cellular sodium ion homeostasis (GO:0006883)3.13310137
55regulation of postsynaptic membrane potential (GO:0060078)3.12817244
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.10463256
57positive regulation of membrane potential (GO:0045838)3.09859809
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09634395
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.05824030
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05660915
61neuromuscular process controlling posture (GO:0050884)3.03712254
62regulation of neurotransmitter secretion (GO:0046928)3.02431153
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01674836
64regulation of synaptic plasticity (GO:0048167)2.99412129
65regulation of voltage-gated calcium channel activity (GO:1901385)2.99241755
66cell migration in hindbrain (GO:0021535)2.98723731
67regulation of dendritic spine morphogenesis (GO:0061001)2.97855189
68regulation of neurotransmitter levels (GO:0001505)2.96959686
69potassium ion import (GO:0010107)2.93576338
70cell differentiation in hindbrain (GO:0021533)2.93244462
71regulation of vesicle fusion (GO:0031338)2.92188824
72adult walking behavior (GO:0007628)2.91495547
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89863032
74L-amino acid import (GO:0043092)2.88692651
75mating behavior (GO:0007617)2.88412635
76semaphorin-plexin signaling pathway (GO:0071526)2.88125209
77regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87114530
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87087104
79membrane depolarization during action potential (GO:0086010)2.86319477
80establishment of nucleus localization (GO:0040023)2.85106227
81positive regulation of neurotransmitter transport (GO:0051590)2.84217123
82positive regulation of neurotransmitter secretion (GO:0001956)2.82178690
83cerebellar Purkinje cell layer development (GO:0021680)2.81357466
84auditory behavior (GO:0031223)2.80883952
85regulation of neurotransmitter transport (GO:0051588)2.79486618
86membrane depolarization (GO:0051899)2.78983187
87long-term synaptic potentiation (GO:0060291)2.78004918
88neuronal ion channel clustering (GO:0045161)2.77320277
89postsynaptic membrane organization (GO:0001941)2.76665394
90innervation (GO:0060384)2.74575891
91cell-cell junction maintenance (GO:0045217)2.73318249
92dopamine receptor signaling pathway (GO:0007212)2.72797162
93membrane hyperpolarization (GO:0060081)2.72505009
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.72324186
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71657843
96regulation of ARF protein signal transduction (GO:0032012)2.71442612
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.71266365
98response to auditory stimulus (GO:0010996)2.68278570
99dendritic spine organization (GO:0097061)2.67039731
100synapse assembly (GO:0007416)2.65924146
101synapse organization (GO:0050808)2.64814845
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.64345395
103prepulse inhibition (GO:0060134)2.63911867
104neuromuscular process (GO:0050905)2.63396238
105vesicle transport along microtubule (GO:0047496)2.63065507
106organelle transport along microtubule (GO:0072384)2.62801964
107regulation of synapse maturation (GO:0090128)2.61638812
108female mating behavior (GO:0060180)2.60670282
109long term synaptic depression (GO:0060292)2.60395307
110potassium ion homeostasis (GO:0055075)2.60184945
111protein retention in ER lumen (GO:0006621)2.56266215
112retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54011565
113regulation of ARF GTPase activity (GO:0032312)2.53000307
114amino acid import (GO:0043090)2.50476984
115protein localization to endosome (GO:0036010)2.46910738
116establishment of mitochondrion localization (GO:0051654)2.44707466
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.44705781
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.43744035
119response to acidic pH (GO:0010447)2.43628387
120adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.42907987
121actin filament depolymerization (GO:0030042)2.41165386
122chemosensory behavior (GO:0007635)2.39968872
123actin filament capping (GO:0051693)2.38564278
124cerebral cortex neuron differentiation (GO:0021895)2.36716309
125neuron remodeling (GO:0016322)2.34065778
126sperm capacitation (GO:0048240)2.33924628
127negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33299554
128macroautophagy (GO:0016236)2.31495345
129Golgi transport vesicle coating (GO:0048200)2.30986254
130COPI coating of Golgi vesicle (GO:0048205)2.30986254
131barbed-end actin filament capping (GO:0051016)2.30740088
132axonemal dynein complex assembly (GO:0070286)2.29883720
133cell junction maintenance (GO:0034331)2.25916931
134mitochondrion transport along microtubule (GO:0047497)2.25261428
135establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.25261428
136positive regulation of dendrite development (GO:1900006)2.23052381
137receptor recycling (GO:0001881)2.21865092
138cellular component maintenance (GO:0043954)2.20746385
139calcium ion-dependent exocytosis (GO:0017156)2.20503716
140cell volume homeostasis (GO:0006884)2.18847038
141maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.18449732
142protein kinase C signaling (GO:0070528)2.18357320
143negative regulation of dendrite morphogenesis (GO:0050774)2.16613705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96405187
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14237011
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07132584
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97822163
5GBX2_23144817_ChIP-Seq_PC3_Human2.95637551
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83331824
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78326048
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78326048
9DROSHA_22980978_ChIP-Seq_HELA_Human2.64279191
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60041668
11LXR_22292898_ChIP-Seq_THP-1_Human2.59016138
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55592211
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50622943
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48697510
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48326030
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43040944
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.34130909
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.30150745
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.28533888
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.26979538
21REST_21632747_ChIP-Seq_MESCs_Mouse2.26392606
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22899135
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.18142879
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09936578
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02797664
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95854977
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89656305
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.87331962
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.77669653
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75448588
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68335717
32* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64115403
33SMC4_20622854_ChIP-Seq_HELA_Human1.63489779
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.62472100
35AR_21572438_ChIP-Seq_LNCaP_Human1.56960142
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54881566
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51547713
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.47910304
39KDM2B_26808549_Chip-Seq_DND41_Human1.46713802
40P68_20966046_ChIP-Seq_HELA_Human1.45908042
41CREB1_26743006_Chip-Seq_LNCaP_Human1.43646794
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.42583423
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40855350
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37885502
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37643923
46KDM2B_26808549_Chip-Seq_K562_Human1.36942266
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.35974235
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35467228
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34653856
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33903230
51SMAD4_21799915_ChIP-Seq_A2780_Human1.33757024
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.32558036
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30460262
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30016235
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29628110
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29272795
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28711788
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27755813
59* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27456773
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26044361
61TP53_22127205_ChIP-Seq_IMR90_Human1.25360271
62TCF7_22412390_ChIP-Seq_EML_Mouse1.25292402
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23036952
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.21359375
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.20968456
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.20963074
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20509653
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20315274
69* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18820576
70ZNF274_21170338_ChIP-Seq_K562_Hela1.18476769
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18452249
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18036652
73AR_19668381_ChIP-Seq_PC3_Human1.18020914
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16719519
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.16101208
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.15912804
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.15555671
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15364631
79* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14560950
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13609189
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13486560
82AHR_22903824_ChIP-Seq_MCF-7_Human1.12347174
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11423647
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10862228
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.10512526
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10443319
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10403073
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10343111
89TP63_22573176_ChIP-Seq_HFKS_Human1.10034217
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09410318
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08959359
92OCT4_19829295_ChIP-Seq_ESCs_Human1.08801125
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08549050
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.07098338
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.06348079
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.06112480
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05875233
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.03372314
99STAT3_23295773_ChIP-Seq_U87_Human1.02582714
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.02476702
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01807155
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.01580516
103ZNF263_19887448_ChIP-Seq_K562_Human1.01147852
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00760632
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00653033
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00383211
107TP53_16413492_ChIP-PET_HCT116_Human1.00010372
108* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99842659
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99797342
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99771499
111AR_25329375_ChIP-Seq_VCAP_Human0.99633156
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.99164346
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98937337
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97856595
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96999921
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.96618535
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95931197
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.95610240
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95369535
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95060318
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94882148
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94655622
123TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93972475
124SA1_27219007_Chip-Seq_Bcells_Human0.93814934
125BCOR_27268052_Chip-Seq_Bcells_Human0.93316262
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93100602
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92884394
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92573866
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92498128
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92380134
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92056493
132P300_19829295_ChIP-Seq_ESCs_Human0.91931707
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91914891
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91689369
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.91073166
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.91040338
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.90867701
138TAF15_26573619_Chip-Seq_HEK293_Human0.90118221
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.90110817
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89664864
141TCF4_23295773_ChIP-Seq_U87_Human0.88529379
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.88206618
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85746702
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84835713
145CTCF_27219007_Chip-Seq_Bcells_Human0.84523408
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84509220
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.84295134
148DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83794037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.21620588
2MP0003880_abnormal_central_pattern4.13872380
3* MP0003635_abnormal_synaptic_transmissio3.88017006
4MP0004270_analgesia3.57940524
5MP0009046_muscle_twitch3.24274228
6* MP0009745_abnormal_behavioral_response3.03085671
7* MP0002064_seizures3.01144443
8MP0002063_abnormal_learning/memory/cond2.96838023
9MP0002734_abnormal_mechanical_nocicepti2.57683609
10MP0002272_abnormal_nervous_system2.54940116
11MP0001968_abnormal_touch/_nociception2.52900908
12MP0002572_abnormal_emotion/affect_behav2.49045320
13MP0005423_abnormal_somatic_nervous2.41901295
14MP0001486_abnormal_startle_reflex2.40763336
15MP0003705_abnormal_hypodermis_morpholog2.25064998
16MP0009780_abnormal_chondrocyte_physiolo2.21104982
17MP0001440_abnormal_grooming_behavior2.15277526
18MP0008569_lethality_at_weaning2.13768782
19MP0003329_amyloid_beta_deposits2.12174354
20MP0002735_abnormal_chemical_nociception2.10127650
21MP0005409_darkened_coat_color2.06549266
22MP0001501_abnormal_sleep_pattern1.96986085
23MP0004858_abnormal_nervous_system1.94637891
24MP0002067_abnormal_sensory_capabilities1.93602918
25MP0005058_abnormal_lysosome_morphology1.93407778
26MP0002736_abnormal_nociception_after1.91189351
27MP0004885_abnormal_endolymph1.91075735
28MP0002733_abnormal_thermal_nociception1.90861593
29MP0000778_abnormal_nervous_system1.90551276
30MP0001970_abnormal_pain_threshold1.89674587
31MP0002184_abnormal_innervation1.83983245
32MP0000955_abnormal_spinal_cord1.68678017
33MP0004811_abnormal_neuron_physiology1.65561901
34MP0002557_abnormal_social/conspecific_i1.61382538
35MP0002909_abnormal_adrenal_gland1.60199844
36MP0000751_myopathy1.56092256
37MP0004145_abnormal_muscle_electrophysio1.55120938
38MP0005386_behavior/neurological_phenoty1.49947957
39MP0004924_abnormal_behavior1.49947957
40MP0009840_abnormal_foam_cell1.49243294
41MP0002882_abnormal_neuron_morphology1.47752517
42MP0003172_abnormal_lysosome_physiology1.45764959
43MP0002066_abnormal_motor_capabilities/c1.43999572
44MP0005623_abnormal_meninges_morphology1.43148302
45MP0003633_abnormal_nervous_system1.41504204
46MP0002822_catalepsy1.40011537
47MP0000920_abnormal_myelination1.36168925
48MP0010234_abnormal_vibrissa_follicle1.33620894
49MP0003879_abnormal_hair_cell1.29004555
50MP0001502_abnormal_circadian_rhythm1.27668794
51MP0004142_abnormal_muscle_tone1.26278317
52MP0005360_urolithiasis1.23159303
53MP0004742_abnormal_vestibular_system1.22119329
54MP0003631_nervous_system_phenotype1.21791868
55MP0001849_ear_inflammation1.20929711
56MP0003690_abnormal_glial_cell1.20108397
57MP0003283_abnormal_digestive_organ1.19956093
58MP0006276_abnormal_autonomic_nervous1.17835835
59MP0003787_abnormal_imprinting1.17596424
60MP0003634_abnormal_glial_cell1.16125048
61MP0008260_abnormal_autophagy1.13496596
62MP0002152_abnormal_brain_morphology1.10694713
63MP0005670_abnormal_white_adipose1.10026218
64MP0001984_abnormal_olfaction1.09828405
65MP0000013_abnormal_adipose_tissue1.09382732
66MP0002229_neurodegeneration1.07529383
67MP0002896_abnormal_bone_mineralization1.07304017
68MP0003122_maternal_imprinting1.06596794
69MP0001765_abnormal_ion_homeostasis1.06346833
70MP0001299_abnormal_eye_distance/1.05102362
71MP0004085_abnormal_heartbeat1.04957537
72MP0001958_emphysema1.04933417
73MP0003191_abnormal_cellular_cholesterol1.04622752
74MP0003279_aneurysm1.04300838
75MP0005646_abnormal_pituitary_gland1.03632288
76MP0003632_abnormal_nervous_system1.02764154
77MP0008438_abnormal_cutaneous_collagen1.02221594
78MP0002089_abnormal_postnatal_growth/wei0.99754698
79MP0005645_abnormal_hypothalamus_physiol0.99688665
80MP0009384_cardiac_valve_regurgitation0.98221688
81MP0001177_atelectasis0.97484453
82MP0003183_abnormal_peptide_metabolism0.97144527
83MP0003091_abnormal_cell_migration0.96955948
84MP0000003_abnormal_adipose_tissue0.96455085
85MP0004215_abnormal_myocardial_fiber0.95894316
86MP0003137_abnormal_impulse_conducting0.95592361
87MP0000604_amyloidosis0.94031235
88MP0005551_abnormal_eye_electrophysiolog0.92349212
89MP0001905_abnormal_dopamine_level0.91141758
90MP0002837_dystrophic_cardiac_calcinosis0.90995292
91MP0002249_abnormal_larynx_morphology0.89391615
92MP0005410_abnormal_fertilization0.89369735
93MP0008961_abnormal_basal_metabolism0.87954610
94MP0000678_abnormal_parathyroid_gland0.87864567
95MP0002069_abnormal_eating/drinking_beha0.86997033
96MP0000681_abnormal_thyroid_gland0.84047973
97MP0001664_abnormal_digestion0.81351050
98MP0001188_hyperpigmentation0.81274135
99MP0004484_altered_response_of0.81126187
100MP0002752_abnormal_somatic_nervous0.80273426
101MP0000569_abnormal_digit_pigmentation0.79354020
102MP0008874_decreased_physiological_sensi0.79236388
103MP0005167_abnormal_blood-brain_barrier0.79140927
104MP0005451_abnormal_body_composition0.79096274
105MP0004233_abnormal_muscle_weight0.78356581
106MP0004510_myositis0.77589946
107MP0003075_altered_response_to0.77197543
108MP0000747_muscle_weakness0.76544467
109MP0002090_abnormal_vision0.76247946
110MP0005248_abnormal_Harderian_gland0.75660268
111MP0001963_abnormal_hearing_physiology0.75321312
112MP0010386_abnormal_urinary_bladder0.74451112
113MP0002653_abnormal_ependyma_morphology0.71755991
114MP0004130_abnormal_muscle_cell0.70016695
115MP0001485_abnormal_pinna_reflex0.69147544
116MP0003123_paternal_imprinting0.67505755
117MP0005375_adipose_tissue_phenotype0.67066531
118MP0004043_abnormal_pH_regulation0.66880356
119MP0005187_abnormal_penis_morphology0.66043498
120MP0001943_abnormal_respiration0.65560675
121MP0005394_taste/olfaction_phenotype0.65464069
122MP0005499_abnormal_olfactory_system0.65464069
123MP0008872_abnormal_physiological_respon0.64809404
124MP0005535_abnormal_body_temperature0.64639788
125MP0005595_abnormal_vascular_smooth0.64349926
126MP0004036_abnormal_muscle_relaxation0.63309120
127MP0001529_abnormal_vocalization0.62769222
128MP0005620_abnormal_muscle_contractility0.61832556
129MP0004264_abnormal_extraembryonic_tissu0.61425946
130MP0001348_abnormal_lacrimal_gland0.58834963
131MP0000534_abnormal_ureter_morphology0.58441129
132MP0003045_fibrosis0.57923012
133MP0003861_abnormal_nervous_system0.57906791
134MP0004019_abnormal_vitamin_homeostasis0.56495802
135MP0010769_abnormal_survival0.55771356

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.22176814
2Focal motor seizures (HP:0011153)5.70533990
3Focal seizures (HP:0007359)4.92260334
4Visual hallucinations (HP:0002367)4.79427466
5Progressive cerebellar ataxia (HP:0002073)4.59643492
6Action tremor (HP:0002345)4.34606140
7Atonic seizures (HP:0010819)4.07999744
8Supranuclear gaze palsy (HP:0000605)3.98005334
9Nuclear cataract (HP:0100018)3.95917713
10Epileptic encephalopathy (HP:0200134)3.77513554
11Distal upper limb amyotrophy (HP:0007149)3.60066830
12Upper limb amyotrophy (HP:0009129)3.60066830
13Febrile seizures (HP:0002373)3.52730095
14Hand muscle atrophy (HP:0009130)3.52221150
15Absence seizures (HP:0002121)3.32973187
16Ankle clonus (HP:0011448)3.22796279
17Dysmetria (HP:0001310)3.20061212
18Gaze-evoked nystagmus (HP:0000640)3.14443661
19Neurofibrillary tangles (HP:0002185)3.11229568
20Dysdiadochokinesis (HP:0002075)3.10971920
21Generalized tonic-clonic seizures (HP:0002069)3.08593821
22Genetic anticipation (HP:0003743)3.06013242
23Broad-based gait (HP:0002136)3.03972061
24Depression (HP:0000716)3.02437758
25Hyperkalemia (HP:0002153)3.00808107
26Scanning speech (HP:0002168)2.98773729
27Dialeptic seizures (HP:0011146)2.98222409
28Mutism (HP:0002300)2.91074148
29Cerebral inclusion bodies (HP:0100314)2.86354122
30Abnormality of the corticospinal tract (HP:0002492)2.81824818
31Intention tremor (HP:0002080)2.81164932
32Hemiplegia (HP:0002301)2.80920119
33Impaired vibration sensation in the lower limbs (HP:0002166)2.75033907
34Hyperactive renin-angiotensin system (HP:0000841)2.71867582
35Truncal ataxia (HP:0002078)2.70875886
36Akinesia (HP:0002304)2.70754720
37Megalencephaly (HP:0001355)2.65209887
38Abnormality of the lower motor neuron (HP:0002366)2.64532099
39Anxiety (HP:0000739)2.64192343
40Urinary bladder sphincter dysfunction (HP:0002839)2.64106611
41Poor eye contact (HP:0000817)2.63382747
42Cerebral aneurysm (HP:0004944)2.62536156
43Abnormal eating behavior (HP:0100738)2.62487364
44Postural instability (HP:0002172)2.59475754
45Hemiparesis (HP:0001269)2.56852213
46Dysmetric saccades (HP:0000641)2.55505034
47Spastic gait (HP:0002064)2.55322983
48Abnormality of binocular vision (HP:0011514)2.52586899
49Diplopia (HP:0000651)2.52586899
50Asymmetric septal hypertrophy (HP:0001670)2.51123838
51Impaired social interactions (HP:0000735)2.48708935
52Abnormal social behavior (HP:0012433)2.48708935
53Thin bony cortex (HP:0002753)2.46997729
54Termporal pattern (HP:0011008)2.46565743
55Insidious onset (HP:0003587)2.46565743
56Impaired smooth pursuit (HP:0007772)2.44636507
57Increased circulating renin level (HP:0000848)2.40822934
58Amblyopia (HP:0000646)2.40016488
59Distal lower limb amyotrophy (HP:0008944)2.38424316
60Ventricular fibrillation (HP:0001663)2.36088679
61Apathy (HP:0000741)2.33775796
62Urinary urgency (HP:0000012)2.32106045
63Torticollis (HP:0000473)2.31218927
64Decreased circulating renin level (HP:0003351)2.29137565
65Pheochromocytoma (HP:0002666)2.28156764
66Agitation (HP:0000713)2.26991370
67Aplasia involving bones of the upper limbs (HP:0009823)2.23476892
68Aplasia of the phalanges of the hand (HP:0009802)2.23476892
69Aplasia involving bones of the extremities (HP:0009825)2.23476892
70Excessive salivation (HP:0003781)2.22803480
71Drooling (HP:0002307)2.22803480
72Broad metatarsal (HP:0001783)2.21896387
73Cervical subluxation (HP:0003308)2.20410863
74Atrophic scars (HP:0001075)2.19425677
75Limb dystonia (HP:0002451)2.19352616
76Abnormality of ocular smooth pursuit (HP:0000617)2.18075932
77Bundle branch block (HP:0011710)2.16579994
78Lower limb muscle weakness (HP:0007340)2.15776036
79Hyperventilation (HP:0002883)2.14609100
80Increased connective tissue (HP:0009025)2.14196938
81Focal dystonia (HP:0004373)2.13789379
82Neuronal loss in central nervous system (HP:0002529)2.13447897
83Diminished motivation (HP:0000745)2.10795003
84Stereotypic behavior (HP:0000733)2.10235092
85Rapidly progressive (HP:0003678)2.06458500
86Insomnia (HP:0100785)2.05274217
87J-shaped sella turcica (HP:0002680)2.04904840
88Atelectasis (HP:0100750)2.04392215
89Obstructive sleep apnea (HP:0002870)2.02777448
90Male infertility (HP:0003251)2.02633301
91Protrusio acetabuli (HP:0003179)2.02295920
92Progressive inability to walk (HP:0002505)2.00934998
93Broad face (HP:0000283)1.99684201
94Stridor (HP:0010307)1.99609256
95Difficulty climbing stairs (HP:0003551)1.99115915
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.98859358
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98859358
98Annular pancreas (HP:0001734)1.98488099
99Myotonia (HP:0002486)1.98339866
100Distal lower limb muscle weakness (HP:0009053)1.97905476
101Papilledema (HP:0001085)1.97287118
102Bradykinesia (HP:0002067)1.96820881
103Status epilepticus (HP:0002133)1.96631433
104Hypoventilation (HP:0002791)1.96282200
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94933335
106Abnormal ciliary motility (HP:0012262)1.94860756
107Postural tremor (HP:0002174)1.94624197
108Premature rupture of membranes (HP:0001788)1.94002574
109Hyperacusis (HP:0010780)1.93087980
110Mucopolysacchariduria (HP:0008155)1.92730968
111Urinary glycosaminoglycan excretion (HP:0003541)1.92730968
112Abnormality of saccadic eye movements (HP:0000570)1.92657264
113Dysostosis multiplex (HP:0000943)1.91758750
114Fetal akinesia sequence (HP:0001989)1.91585099
115Pointed chin (HP:0000307)1.87417810
116Gait ataxia (HP:0002066)1.87149436
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86371833
118Abnormality of polysaccharide metabolism (HP:0011012)1.86371833
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86371833
120Growth hormone excess (HP:0000845)1.85526557
121Lower limb asymmetry (HP:0100559)1.85047211
122Achilles tendon contracture (HP:0001771)1.84049291
123Lower limb amyotrophy (HP:0007210)1.83829162
124Peripheral hypomyelination (HP:0007182)1.81765968
125Shallow orbits (HP:0000586)1.81468717
126Abnormality of the nasal mucosa (HP:0000433)1.81132813
127Craniofacial dystonia (HP:0012179)1.80332754
128Neuroendocrine neoplasm (HP:0100634)1.79341522
129Abnormal respiratory epithelium morphology (HP:0012253)1.79002929
130Abnormal respiratory motile cilium morphology (HP:0005938)1.79002929
131Psychosis (HP:0000709)1.78196043
132Incomplete penetrance (HP:0003829)1.78117004
133Hammertoe (HP:0001765)1.77618256
134Epileptiform EEG discharges (HP:0011182)1.77579348
135Sudden death (HP:0001699)1.77254543
136Prolonged QT interval (HP:0001657)1.76919498
137Infertility (HP:0000789)1.76875942
138Rigidity (HP:0002063)1.76675849
139Clonus (HP:0002169)1.76578818
140EEG with generalized epileptiform discharges (HP:0011198)1.75975754
141Bronchomalacia (HP:0002780)1.75637815
142Abnormal atrioventricular conduction (HP:0005150)1.75590048
143Polyphagia (HP:0002591)1.75400361
144Slow progression (HP:0003677)1.74677197
145Impaired vibratory sensation (HP:0002495)1.74641063
146Hypercortisolism (HP:0001578)1.73552398
147Abnormal respiratory motile cilium physiology (HP:0012261)1.73410671
148Short nail (HP:0001799)1.73311368
149Generalized myoclonic seizures (HP:0002123)1.72635918
150Hyperparathyroidism (HP:0000843)1.68685602
151Nasal polyposis (HP:0100582)1.66816597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.48498094
2TESK13.22895342
3MAP3K93.20029384
4TAOK23.15198965
5MARK13.10223851
6EPHA42.67625421
7DAPK22.66865043
8MAP3K42.64528976
9MINK12.51329204
10PAK62.49677997
11MAP2K62.41242080
12NTRK22.18006957
13MAP2K72.05700667
14NTRK11.88749848
15SIK11.87474739
16PRKD31.87421172
17CAMKK11.81354764
18KSR21.76619932
19MAP2K41.73998590
20TYRO31.71266132
21PRPF4B1.67832120
22ERN11.57264425
23CDK51.51908098
24PHKG11.49435383
25PHKG21.49435383
26GRK51.48386484
27STK381.45340043
28CDK121.43178462
29PLK21.41631071
30EPHA21.40117527
31CAMKK21.37649705
32UHMK11.35425688
33CASK1.34866050
34SIK21.31115008
35RPS6KA21.29126092
36MAP3K111.27791240
37WNK11.27570438
38CDK191.22565168
39MAP3K121.21983977
40SGK2231.21440511
41SGK4941.21440511
42OXSR11.20842634
43RIPK11.19738298
44RIPK41.13534802
45PAK31.13503889
46TESK21.12406196
47PRKCG1.11197075
48RET1.10744551
49PNCK1.09035885
50KSR11.07843622
51MAPK131.06423822
52MAP3K21.06341394
53PTK2B1.06202828
54PRKCH1.05502320
55LATS21.05112841
56PKN21.02724116
57CDK151.01839333
58STK391.01190803
59CDK181.00770792
60TAOK10.99027519
61MAPK150.97839934
62CDK140.97321087
63DAPK10.91964580
64CAMK2A0.91744692
65CAMK10.91708706
66FGFR20.91246258
67DDR20.90771621
68LMTK20.90624498
69NEK60.90356430
70EEF2K0.89524112
71MARK20.88803194
72STK110.88743795
73CDK11A0.88553577
74FES0.85339391
75CAMK1G0.84983262
76CAMK2B0.84043738
77FGFR40.83862587
78PRKG20.81907107
79PDGFRA0.81712224
80PKN10.81576347
81FER0.81046392
82DYRK1B0.80073854
83DMPK0.77673116
84CSNK1G20.77544796
85CDC42BPA0.76994249
86MAP3K130.76397731
87MST1R0.76147011
88ALK0.75555617
89TNIK0.75228557
90TRIB30.73849848
91ROCK20.73518630
92TIE10.72583566
93PRKD20.72216406
94SGK30.71938389
95CAMK2D0.70070400
96DAPK30.70063938
97PDPK10.67393337
98MAP2K20.65471276
99PINK10.65406345
100MAPKAPK50.65128667
101LIMK10.64885282
102SGK20.64874293
103DYRK1A0.63975371
104CAMK2G0.63583803
105ICK0.63540455
106ARAF0.62169027
107MAP3K70.61960553
108SGK10.61931158
109TTN0.61016008
110PTK20.60382987
111PRKCE0.60349548
112MAP3K30.59222311
113ERBB20.58986445
114TNK20.57145251
115MTOR0.56793190
116PDK10.56419940
117MATK0.55518049
118MAP3K50.55350551
119FYN0.54974567
120BCR0.54090979
121CAMK40.54007706
122PRKD10.52776028
123WNK40.52238576
124PIM20.52035227
125BRAF0.50156310
126MAP3K10.49882014
127FGR0.49231729
128PTK60.49080232
129MAPK100.48448984
130RPS6KA30.47818466
131PRKCZ0.47213469
132EPHB10.45511682
133MAPK120.43858412
134PRKCI0.39495575
135TBK10.39182069
136MAP2K30.38790159

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.06661397
2Nicotine addiction_Homo sapiens_hsa050333.03386207
3Circadian entrainment_Homo sapiens_hsa047132.48566674
4GABAergic synapse_Homo sapiens_hsa047272.46066373
5Glutamatergic synapse_Homo sapiens_hsa047242.45957743
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38921660
7Long-term potentiation_Homo sapiens_hsa047202.34478733
8Morphine addiction_Homo sapiens_hsa050322.23179106
9Olfactory transduction_Homo sapiens_hsa047402.22661555
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20149229
11Salivary secretion_Homo sapiens_hsa049702.06444764
12Amphetamine addiction_Homo sapiens_hsa050311.94570759
13Gastric acid secretion_Homo sapiens_hsa049711.85050440
14Dopaminergic synapse_Homo sapiens_hsa047281.84549532
15Insulin secretion_Homo sapiens_hsa049111.81598325
16Cholinergic synapse_Homo sapiens_hsa047251.79989491
17Long-term depression_Homo sapiens_hsa047301.76270510
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73373108
19Taste transduction_Homo sapiens_hsa047421.66684504
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66168390
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64216435
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60979658
23Oxytocin signaling pathway_Homo sapiens_hsa049211.53186671
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49658905
25Renin secretion_Homo sapiens_hsa049241.44500562
26Serotonergic synapse_Homo sapiens_hsa047261.41664508
27Gap junction_Homo sapiens_hsa045401.40848487
28GnRH signaling pathway_Homo sapiens_hsa049121.40712142
29Cocaine addiction_Homo sapiens_hsa050301.38065602
30Calcium signaling pathway_Homo sapiens_hsa040201.35979352
31Other glycan degradation_Homo sapiens_hsa005111.32355439
32Collecting duct acid secretion_Homo sapiens_hsa049661.31842616
33Axon guidance_Homo sapiens_hsa043601.29398882
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27738366
35Type II diabetes mellitus_Homo sapiens_hsa049301.27319873
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18673876
37cAMP signaling pathway_Homo sapiens_hsa040241.18603806
38Estrogen signaling pathway_Homo sapiens_hsa049151.18301207
39Phenylalanine metabolism_Homo sapiens_hsa003601.14445739
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14396019
41Glioma_Homo sapiens_hsa052141.12574867
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.09264006
43Dilated cardiomyopathy_Homo sapiens_hsa054141.08295648
44Cardiac muscle contraction_Homo sapiens_hsa042601.05392708
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04790337
46Melanogenesis_Homo sapiens_hsa049161.04157099
47ErbB signaling pathway_Homo sapiens_hsa040121.03457080
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03117132
49Nitrogen metabolism_Homo sapiens_hsa009101.02961671
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01155456
51Arginine biosynthesis_Homo sapiens_hsa002200.99030812
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.98190932
53Vibrio cholerae infection_Homo sapiens_hsa051100.97470431
54Notch signaling pathway_Homo sapiens_hsa043300.96417170
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.95769365
56Dorso-ventral axis formation_Homo sapiens_hsa043200.91322668
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.89714564
58Pancreatic secretion_Homo sapiens_hsa049720.89258776
59Histidine metabolism_Homo sapiens_hsa003400.82266211
60Thyroid hormone synthesis_Homo sapiens_hsa049180.81934963
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81561873
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80239890
63Fatty acid biosynthesis_Homo sapiens_hsa000610.77228957
64Lysosome_Homo sapiens_hsa041420.76705271
65Choline metabolism in cancer_Homo sapiens_hsa052310.76562750
66ABC transporters_Homo sapiens_hsa020100.76058770
67AMPK signaling pathway_Homo sapiens_hsa041520.74238765
68VEGF signaling pathway_Homo sapiens_hsa043700.72280810
69Protein digestion and absorption_Homo sapiens_hsa049740.70969723
70Endocytosis_Homo sapiens_hsa041440.70753079
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70634810
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69809563
73MAPK signaling pathway_Homo sapiens_hsa040100.69149206
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.67500282
75Rap1 signaling pathway_Homo sapiens_hsa040150.66628789
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65333205
77Renal cell carcinoma_Homo sapiens_hsa052110.63644751
78Phototransduction_Homo sapiens_hsa047440.63511699
79Ras signaling pathway_Homo sapiens_hsa040140.62556831
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62099069
81Circadian rhythm_Homo sapiens_hsa047100.61655093
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.60768563
83Bile secretion_Homo sapiens_hsa049760.60655045
84Oocyte meiosis_Homo sapiens_hsa041140.60622858
85Fructose and mannose metabolism_Homo sapiens_hsa000510.58287368
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56468503
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56403064
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55691764
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55616333
90Mineral absorption_Homo sapiens_hsa049780.54800965
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54798481
92Tight junction_Homo sapiens_hsa045300.53675080
93Arginine and proline metabolism_Homo sapiens_hsa003300.53660893
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.53367861
95PPAR signaling pathway_Homo sapiens_hsa033200.53366152
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53274861
97Prolactin signaling pathway_Homo sapiens_hsa049170.52728546
98Inositol phosphate metabolism_Homo sapiens_hsa005620.52316648
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51013876
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.50896141
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50082205
102Ovarian steroidogenesis_Homo sapiens_hsa049130.49886377
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.49489341
104mTOR signaling pathway_Homo sapiens_hsa041500.49291370
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47782462
106Insulin signaling pathway_Homo sapiens_hsa049100.46809016
107Glucagon signaling pathway_Homo sapiens_hsa049220.46753627
108Endometrial cancer_Homo sapiens_hsa052130.46394176
109Prion diseases_Homo sapiens_hsa050200.43285894
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42220641
111Non-small cell lung cancer_Homo sapiens_hsa052230.41362957
112Wnt signaling pathway_Homo sapiens_hsa043100.40572769
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40070574
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39553450
115Focal adhesion_Homo sapiens_hsa045100.39511899
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37354749
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37070767
118Proteoglycans in cancer_Homo sapiens_hsa052050.35736787
119Platelet activation_Homo sapiens_hsa046110.35595643
120Chemokine signaling pathway_Homo sapiens_hsa040620.34458549
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33194134
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32576650
123Amoebiasis_Homo sapiens_hsa051460.32211087
124Alzheimers disease_Homo sapiens_hsa050100.30806441

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