TRIM31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.87938856
2angiotensin maturation (GO:0002003)8.98100659
3vitamin A metabolic process (GO:0006776)6.23171553
4flavonoid metabolic process (GO:0009812)5.95542584
5actin filament depolymerization (GO:0030042)5.91950884
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.90420533
7cellular glucuronidation (GO:0052695)5.83250318
8UDP-N-acetylglucosamine metabolic process (GO:0006047)5.79597800
9uronic acid metabolic process (GO:0006063)5.62406610
10glucuronate metabolic process (GO:0019585)5.62406610
11digestive system process (GO:0022600)5.57365712
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.55094325
13intestinal epithelial cell development (GO:0060576)5.49808740
14regulation of respiratory burst (GO:0060263)5.49197290
15maintenance of gastrointestinal epithelium (GO:0030277)5.42561591
16positive regulation of respiratory burst (GO:0060267)5.35639575
17regulation of bile acid biosynthetic process (GO:0070857)5.35280284
18virion attachment to host cell (GO:0019062)5.09773789
19adhesion of symbiont to host cell (GO:0044650)5.09773789
20drug catabolic process (GO:0042737)4.89826457
21epoxygenase P450 pathway (GO:0019373)4.81608792
223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.80672454
23purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.80672454
24sulfation (GO:0051923)4.76837595
25positive regulation of guanylate cyclase activity (GO:0031284)4.70371985
26bile acid and bile salt transport (GO:0015721)4.68336626
27phospholipid efflux (GO:0033700)4.45088128
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44094811
29modified amino acid transport (GO:0072337)4.33329895
30ethanol oxidation (GO:0006069)4.33125611
31positive regulation of triglyceride lipase activity (GO:0061365)4.32391811
32positive regulation of lipoprotein lipase activity (GO:0051006)4.32391811
33NADH metabolic process (GO:0006734)4.27749170
34glucose 6-phosphate metabolic process (GO:0051156)4.26508276
35response to hepatocyte growth factor (GO:0035728)4.26334081
36cellular response to hepatocyte growth factor stimulus (GO:0035729)4.26334081
37regulation of hydrogen peroxide metabolic process (GO:0010310)4.26240146
38regulation of cellular extravasation (GO:0002691)4.24650101
39renal system process involved in regulation of blood volume (GO:0001977)4.23575565
40drug metabolic process (GO:0017144)4.22418126
41negative regulation of epidermal cell differentiation (GO:0045605)4.20533671
42antibacterial humoral response (GO:0019731)4.18314023
43regulation of cGMP biosynthetic process (GO:0030826)4.18116625
44digestion (GO:0007586)4.16211018
45oligosaccharide biosynthetic process (GO:0009312)4.13009230
46regulation of cholesterol esterification (GO:0010872)4.12502239
47glomerular filtration (GO:0003094)4.09831636
48regulation of triglyceride catabolic process (GO:0010896)4.09564923
49sulfate transmembrane transport (GO:1902358)4.09409010
50antimicrobial humoral response (GO:0019730)4.09356441
51fat-soluble vitamin biosynthetic process (GO:0042362)4.04585471
52epithelial structure maintenance (GO:0010669)4.01585648
53adhesion of symbiont to host (GO:0044406)4.00413174
54lipoprotein metabolic process (GO:0042157)3.99326830
55plasma lipoprotein particle assembly (GO:0034377)3.98646045
56positive regulation of pseudopodium assembly (GO:0031274)3.95614262
57alkaloid metabolic process (GO:0009820)3.93745179
58arginine metabolic process (GO:0006525)3.93130852
59O-glycan processing (GO:0016266)3.93064052
60regulation of systemic arterial blood pressure (GO:0003073)3.87987934
61protein-lipid complex assembly (GO:0065005)3.85192540
62renal filtration (GO:0097205)3.80592695
63lung secretory cell differentiation (GO:0061140)3.79620704
64thyroid hormone metabolic process (GO:0042403)3.78412114
65drug transmembrane transport (GO:0006855)3.76107370
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.74870594
67sulfur compound transport (GO:0072348)3.71715214
68urea cycle (GO:0000050)3.69249392
69regulation of cholesterol homeostasis (GO:2000188)3.68375473
70GDP-mannose metabolic process (GO:0019673)3.67569996
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.65340629
72desmosome organization (GO:0002934)3.65206400
73complement activation, classical pathway (GO:0006958)3.65076851
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65040009
75urea metabolic process (GO:0019627)3.62705992
76ethanol metabolic process (GO:0006067)3.60515686
77auditory receptor cell differentiation (GO:0042491)3.55515300
78diacylglycerol metabolic process (GO:0046339)3.54295744
79regulation of vitamin metabolic process (GO:0030656)3.53954583
80regulation of actin nucleation (GO:0051125)3.53816185
81bicarbonate transport (GO:0015701)3.53153800
82regulation of pseudopodium assembly (GO:0031272)3.52590319
83vitamin transmembrane transport (GO:0035461)3.51728878
84cellular response to pH (GO:0071467)3.49391711
85hepatocyte apoptotic process (GO:0097284)3.48549765
86regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.47668710
87drug transport (GO:0015893)3.47326523
88hemidesmosome assembly (GO:0031581)3.47255737
89hormone catabolic process (GO:0042447)3.46670071
90purine nucleotide salvage (GO:0032261)3.45864407
91transcytosis (GO:0045056)3.44707768
92cholesterol efflux (GO:0033344)3.44697591
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42918433
94renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.40935417
95arginine catabolic process (GO:0006527)3.40860059
96fucosylation (GO:0036065)3.40260366
97peptide hormone processing (GO:0016486)3.39103904
98regulation of cGMP metabolic process (GO:0030823)3.38979621
99very-low-density lipoprotein particle assembly (GO:0034379)3.35976554
100sulfate transport (GO:0008272)3.34727448
101nitrogen cycle metabolic process (GO:0071941)3.33468833
102cytidine deamination (GO:0009972)3.33439071
103cytidine metabolic process (GO:0046087)3.33439071
104cytidine catabolic process (GO:0006216)3.33439071
105phenylpropanoid metabolic process (GO:0009698)3.30774659
106transepithelial transport (GO:0070633)3.30495308
107defense response to fungus (GO:0050832)3.30451535
108sperm capacitation (GO:0048240)3.30391254
109cholesterol homeostasis (GO:0042632)3.30318479
110exogenous drug catabolic process (GO:0042738)3.28807482
111sterol homeostasis (GO:0055092)3.28266985
112disruption of cells of other organism (GO:0044364)3.27065935
113killing of cells of other organism (GO:0031640)3.27065935
114negative regulation of sterol transport (GO:0032372)3.27060503
115negative regulation of cholesterol transport (GO:0032375)3.27060503
116drinking behavior (GO:0042756)3.25912455
117oligosaccharide catabolic process (GO:0009313)3.25821472
118lipoprotein transport (GO:0042953)3.25688513
119cGMP-mediated signaling (GO:0019934)3.25317545
120thrombin receptor signaling pathway (GO:0070493)3.23540336
121bile acid metabolic process (GO:0008206)3.20597721
122receptor guanylyl cyclase signaling pathway (GO:0007168)3.18485080
123plasma lipoprotein particle remodeling (GO:0034369)3.17747105
124protein-lipid complex remodeling (GO:0034368)3.17747105
125macromolecular complex remodeling (GO:0034367)3.17747105
126pyrimidine-containing compound transmembrane transport (GO:0072531)3.16350271
127glucocorticoid biosynthetic process (GO:0006704)3.15068391
128sodium ion homeostasis (GO:0055078)3.14128895
129mucosal immune response (GO:0002385)3.13289086
130cholesterol transport (GO:0030301)3.13281397
131sterol transport (GO:0015918)3.13281397
132phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12334186
133positive regulation of fatty acid oxidation (GO:0046321)3.11248935
134proline biosynthetic process (GO:0006561)3.10707077
135negative regulation of keratinocyte proliferation (GO:0010839)3.09748135
136peptide catabolic process (GO:0043171)3.09427847
137positive regulation of fatty acid biosynthetic process (GO:0045723)3.08620475
138glycerol metabolic process (GO:0006071)3.07517895
139regulation of keratinocyte proliferation (GO:0010837)3.06198521
140endocrine process (GO:0050886)3.04074519
141regulation of systemic arterial blood pressure by hormone (GO:0001990)3.04074519
142regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.04074519
143regulation of guanylate cyclase activity (GO:0031282)3.04073544
144negative regulation of myotube differentiation (GO:0010832)3.03728543
145antigen processing and presentation of endogenous antigen (GO:0019883)3.03544796
146positive regulation of lipid catabolic process (GO:0050996)3.01153725
147nucleoside diphosphate biosynthetic process (GO:0009133)3.00634871
148negative regulation of epidermis development (GO:0045683)2.98343205
149fucose catabolic process (GO:0019317)2.98087166
150L-fucose metabolic process (GO:0042354)2.98087166
151L-fucose catabolic process (GO:0042355)2.98087166
152hydrogen peroxide metabolic process (GO:0042743)2.97447280
153striated muscle atrophy (GO:0014891)2.97069043
154fructose metabolic process (GO:0006000)2.96961731
155phosphatidylserine acyl-chain remodeling (GO:0036150)2.95937824
156positive regulation of glycoprotein biosynthetic process (GO:0010560)2.95148721
157organ or tissue specific immune response (GO:0002251)2.94830722
158innate immune response in mucosa (GO:0002227)2.94084065
159sulfur amino acid catabolic process (GO:0000098)2.93899858
160plasma lipoprotein particle organization (GO:0071827)2.91014817
161positive regulation of cGMP biosynthetic process (GO:0030828)2.89936506
162intestinal absorption (GO:0050892)11.1339586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.48638169
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.76744487
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.86143995
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.31925970
5GATA4_25053715_ChIP-Seq_YYC3_Human3.11271989
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07522779
7CDX2_19796622_ChIP-Seq_MESCs_Mouse3.01293213
8* SOX2_20726797_ChIP-Seq_SW620_Human2.98312443
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.96822323
10* GATA6_25053715_ChIP-Seq_YYC3_Human2.86572121
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.74943417
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.70656974
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.56777451
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14656198
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.13924567
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03093377
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.02746763
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.02513531
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01934264
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01653490
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00846465
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.98033560
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91110196
24* KLF5_25053715_ChIP-Seq_YYC3_Human1.80765772
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78606722
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.71795330
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.70716499
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.59683692
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57758266
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54756455
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54576435
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.52774842
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52539679
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52166725
35ZNF263_19887448_ChIP-Seq_K562_Human1.51904328
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49472701
37RACK7_27058665_Chip-Seq_MCF-7_Human1.48376772
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.48240678
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48240574
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42689166
41AR_21909140_ChIP-Seq_LNCAP_Human1.42088483
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38544882
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.37270287
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.35408855
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34869444
46CEBPB_22108803_ChIP-Seq_LS180_Human1.32123214
47ATF3_27146783_Chip-Seq_COLON_Human1.30933695
48DROSHA_22980978_ChIP-Seq_HELA_Human1.29204899
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28733630
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27770205
51* HNF4A_19822575_ChIP-Seq_HepG2_Human1.23474991
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23086219
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23054532
54* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22892869
55VDR_22108803_ChIP-Seq_LS180_Human1.21165950
56E2F1_20622854_ChIP-Seq_HELA_Human1.14425091
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13435297
58GATA2_19941826_ChIP-Seq_K562_Human1.12813151
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10650451
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09122889
61SA1_27219007_Chip-Seq_Bcells_Human1.07182527
62STAT1_20625510_ChIP-Seq_HELA_Human1.05396102
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.05283540
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05165623
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02810919
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01048585
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00281462
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00138032
69JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00091710
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98793047
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98638738
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98527330
73FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97789320
74STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97721773
75RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96693290
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95119478
77* TP63_22573176_ChIP-Seq_HFKS_Human0.95118014
78GATA3_24758297_ChIP-Seq_MCF-7_Human0.95024140
79TP53_16413492_ChIP-PET_HCT116_Human0.94467471
80FOXA2_19822575_ChIP-Seq_HepG2_Human0.93776825
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92953306
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.92760671
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92744394
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92744394
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92622017
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92337734
87CREB1_26743006_Chip-Seq_LNCaP_Human0.92295001
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92187425
89BCAT_22108803_ChIP-Seq_LS180_Human0.91876206
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91029895
91* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90457960
92P300_27268052_Chip-Seq_Bcells_Human0.90383788
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89941087
94* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89918461
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88994596
96CTCF_20526341_ChIP-Seq_ESCs_Human0.88900718
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88627435
98* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87245653
99P53_21459846_ChIP-Seq_SAOS-2_Human0.86912283
100CDX2_22108803_ChIP-Seq_LS180_Human0.86450005
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.85561509
102CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84645956
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83902152
104P68_20966046_ChIP-Seq_HELA_Human0.83169190
105PHF8_20622854_ChIP-Seq_HELA_Human0.83059070
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82859257
107LXR_22292898_ChIP-Seq_THP-1_Human0.82620103
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82339050
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.82016749
110BCL6_27268052_Chip-Seq_Bcells_Human0.82015254
111EGR1_19032775_ChIP-ChIP_M12_Human0.81881668
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81660375
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80369404
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.80122557
115* NANOG_20526341_ChIP-Seq_ESCs_Human0.79953735
116ELF5_23300383_ChIP-Seq_T47D_Human0.79083238
117TAF2_19829295_ChIP-Seq_ESCs_Human0.78543948
118ETS1_21867929_ChIP-Seq_TH2_Mouse0.78177423
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77137353
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76605543
121FOXH1_21741376_ChIP-Seq_ESCs_Human0.76369479
122BCOR_27268052_Chip-Seq_Bcells_Human0.75705745
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75432438
124GATA1_19941826_ChIP-Seq_K562_Human0.75174417
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74731887
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74405634
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74217914
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72198271
129CTCF_27219007_Chip-Seq_Bcells_Human0.70671789
130* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70602433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.17844964
2MP0009840_abnormal_foam_cell5.52047042
3MP0001666_abnormal_nutrient_absorption5.33093247
4MP0010234_abnormal_vibrissa_follicle4.56393740
5MP0000462_abnormal_digestive_system4.41711343
6MP0004264_abnormal_extraembryonic_tissu3.79154574
7MP0003866_abnormal_defecation3.37613038
8MP0005085_abnormal_gallbladder_physiolo3.13826213
9MP0002138_abnormal_hepatobiliary_system3.12049944
10MP0002139_abnormal_hepatobiliary_system2.94045576
11MP0003183_abnormal_peptide_metabolism2.81407911
12MP0008875_abnormal_xenobiotic_pharmacok2.68033386
13MP0003252_abnormal_bile_duct2.56622049
14MP0005381_digestive/alimentary_phenotyp2.53940090
15MP0001873_stomach_inflammation2.45479867
16MP0010155_abnormal_intestine_physiology2.41049692
17MP0001663_abnormal_digestive_system2.39445174
18MP0002822_catalepsy2.23953892
19MP0000490_abnormal_crypts_of2.23755713
20MP0000477_abnormal_intestine_morphology1.99682951
21MP0005377_hearing/vestibular/ear_phenot1.98510939
22MP0003878_abnormal_ear_physiology1.98510939
23MP0010329_abnormal_lipoprotein_level1.96209927
24MP0009379_abnormal_foot_pigmentation1.92993903
25MP0000537_abnormal_urethra_morphology1.90425451
26MP0001664_abnormal_digestion1.86555912
27MP0002102_abnormal_ear_morphology1.82071974
28MP0004019_abnormal_vitamin_homeostasis1.81494261
29MP0010352_gastrointestinal_tract_polyps1.80947849
30MP0000538_abnormal_urinary_bladder1.77059177
31MP0003705_abnormal_hypodermis_morpholog1.68116154
32MP0004147_increased_porphyrin_level1.62398229
33MP0005365_abnormal_bile_salt1.60983461
34MP0003300_gastrointestinal_ulcer1.55356267
35MP0002796_impaired_skin_barrier1.51116090
36MP0000566_synostosis1.45788957
37MP0004043_abnormal_pH_regulation1.42320199
38MP0000465_gastrointestinal_hemorrhage1.41753775
39MP0005670_abnormal_white_adipose1.32684328
40MP0005174_abnormal_tail_pigmentation1.30530960
41MP0003191_abnormal_cellular_cholesterol1.28915272
42MP0005409_darkened_coat_color1.28839375
43MP0002166_altered_tumor_susceptibility1.28138909
44MP0003806_abnormal_nucleotide_metabolis1.20903174
45MP0005448_abnormal_energy_balance1.20567001
46MP0005084_abnormal_gallbladder_morpholo1.19773076
47MP0003315_abnormal_perineum_morphology1.17585610
48MP0003868_abnormal_feces_composition1.13497776
49MP0003724_increased_susceptibility_to1.13273109
50MP0002876_abnormal_thyroid_physiology1.08910382
51MP0001849_ear_inflammation1.08296781
52MP0006054_spinal_hemorrhage1.07433311
53MP0004947_skin_inflammation1.06413677
54MP0003283_abnormal_digestive_organ1.04433845
55MP0005167_abnormal_blood-brain_barrier1.03108520
56MP0009643_abnormal_urine_homeostasis1.01812749
57MP0002006_tumorigenesis0.99088171
58MP0001756_abnormal_urination0.97798303
59MP0002277_abnormal_respiratory_mucosa0.95671960
60MP0000230_abnormal_systemic_arterial0.93064912
61MP0001188_hyperpigmentation0.92795074
62MP0010678_abnormal_skin_adnexa0.92462690
63MP0003718_maternal_effect0.90695544
64MP0005501_abnormal_skin_physiology0.89752249
65MP0001765_abnormal_ion_homeostasis0.89512104
66MP0002060_abnormal_skin_morphology0.89215223
67MP0008872_abnormal_physiological_respon0.88350727
68MP0001845_abnormal_inflammatory_respons0.87920024
69MP0002089_abnormal_postnatal_growth/wei0.85381991
70MP0001485_abnormal_pinna_reflex0.84937962
71MP0005166_decreased_susceptibility_to0.84825801
72MP0002254_reproductive_system_inflammat0.83392082
73MP0001216_abnormal_epidermal_layer0.80408626
74MP0003453_abnormal_keratinocyte_physiol0.80399839
75MP0003938_abnormal_ear_development0.79367167
76MP0005165_increased_susceptibility_to0.79025899
77MP0002118_abnormal_lipid_homeostasis0.77994436
78MP0003693_abnormal_embryo_hatching0.77297316
79MP0000467_abnormal_esophagus_morphology0.76396686
80MP0005451_abnormal_body_composition0.76187165
81MP0002971_abnormal_brown_adipose0.73125008
82MP0005636_abnormal_mineral_homeostasis0.72871819
83MP0005332_abnormal_amino_acid0.72533107
84MP0000377_abnormal_hair_follicle0.71854733
85MP0000609_abnormal_liver_physiology0.70956836
86MP0003879_abnormal_hair_cell0.70498650
87MP0009780_abnormal_chondrocyte_physiolo0.70490194
88MP0005025_abnormal_response_to0.70128538
89MP0005310_abnormal_salivary_gland0.68691300
90MP0002098_abnormal_vibrissa_morphology0.66927232
91MP0009697_abnormal_copulation0.65398632
92MP0004858_abnormal_nervous_system0.64232659
93MP0005535_abnormal_body_temperature0.62191861
94MP0000470_abnormal_stomach_morphology0.61350814
95MP0003045_fibrosis0.61274698
96MP0009642_abnormal_blood_homeostasis0.60291348
97MP0004782_abnormal_surfactant_physiolog0.60166651
98MP0003119_abnormal_digestive_system0.58744440
99MP0000678_abnormal_parathyroid_gland0.58412465
100MP0008469_abnormal_protein_level0.57966817
101MP0010771_integument_phenotype0.57352131
102MP0001835_abnormal_antigen_presentation0.57162224
103MP0002136_abnormal_kidney_physiology0.55902786
104MP0000015_abnormal_ear_pigmentation0.55432155
105MP0002896_abnormal_bone_mineralization0.55431032
106MP0003953_abnormal_hormone_level0.54283229
107MP0005387_immune_system_phenotype0.54229684
108MP0001790_abnormal_immune_system0.54229684
109MP0005319_abnormal_enzyme/_coenzyme0.53131128
110MP0004484_altered_response_of0.52985798
111MP0004270_analgesia0.51469084
112MP0005666_abnormal_adipose_tissue0.51038012
113MP0000579_abnormal_nail_morphology0.50950022
114MP0009053_abnormal_anal_canal0.50123591
115MP0001764_abnormal_homeostasis0.49342799
116MP0009115_abnormal_fat_cell0.49252789
117MP0006082_CNS_inflammation0.47271788
118MP0009333_abnormal_splenocyte_physiolog0.47004272
119MP0008004_abnormal_stomach_pH0.45858801
120MP0009785_altered_susceptibility_to0.44338719
121MP0003656_abnormal_erythrocyte_physiolo0.43652387
122MP0003941_abnormal_skin_development0.43348766
123MP0005266_abnormal_metabolism0.43241680
124MP0003950_abnormal_plasma_membrane0.43134104
125MP0005023_abnormal_wound_healing0.43103364
126MP0008873_increased_physiological_sensi0.41691826
127MP0005584_abnormal_enzyme/coenzyme_acti0.40313859
128MP0001501_abnormal_sleep_pattern0.40244135
129MP0000613_abnormal_salivary_gland0.40098721

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.30528142
2Decreased circulating renin level (HP:0003351)6.49718069
3Abnormality of glutamine family amino acid metabolism (HP:0010902)6.16909485
4Right ventricular cardiomyopathy (HP:0011663)5.91658428
5Abnormality of renin-angiotensin system (HP:0000847)5.79688685
6Acanthocytosis (HP:0001927)5.50459686
7Malnutrition (HP:0004395)5.38944748
8Hypobetalipoproteinemia (HP:0003563)4.86044200
9Alkalosis (HP:0001948)4.83999342
10Abnormality of proline metabolism (HP:0010907)4.55637888
11Hydroxyprolinuria (HP:0003080)4.55637888
12Conjugated hyperbilirubinemia (HP:0002908)4.50427319
13Cupped ribs (HP:0000887)4.19819958
14Hyperaldosteronism (HP:0000859)4.18966503
15Autoimmune thrombocytopenia (HP:0001973)4.11777610
16Pustule (HP:0200039)4.06799363
17Abdominal distention (HP:0003270)4.02377551
18Hemorrhage of the eye (HP:0011885)3.90994167
19Widely patent fontanelles and sutures (HP:0004492)3.90841177
20Chronic diarrhea (HP:0002028)3.69789314
21Gastrointestinal dysmotility (HP:0002579)3.60080547
22Fat malabsorption (HP:0002630)3.56408465
23Wide cranial sutures (HP:0010537)3.47904179
24Rectal prolapse (HP:0002035)3.35779793
25Systemic lupus erythematosus (HP:0002725)3.35010856
26Milia (HP:0001056)3.34612299
27Abnormality of the vitamin B12 metabolism (HP:0004341)3.34146414
28Autoimmune hemolytic anemia (HP:0001890)3.18386128
29Poikilocytosis (HP:0004447)3.18224093
30Pigmentary retinal degeneration (HP:0001146)3.14289945
31Flat acetabular roof (HP:0003180)3.12480592
32Abnormality of vitamin B metabolism (HP:0004340)3.09852310
33Pili torti (HP:0003777)3.06002237
34Hyponatremia (HP:0002902)3.05866212
35Dehydration (HP:0001944)3.03163163
36Villous atrophy (HP:0011473)2.95902213
37Abnormality of small intestinal villus morphology (HP:0011472)2.95902213
38Woolly hair (HP:0002224)2.95202095
39Congenital sensorineural hearing impairment (HP:0008527)2.94500008
40Ventricular fibrillation (HP:0001663)2.93005117
41Hyperkalemia (HP:0002153)2.92415382
42Hyperactive renin-angiotensin system (HP:0000841)2.90227445
43Hypokalemia (HP:0002900)2.90214475
44Abnormality of potassium homeostasis (HP:0011042)2.89379066
45Hypolipoproteinemia (HP:0010981)2.88472786
46Glycosuria (HP:0003076)2.85042785
47Abnormality of urine glucose concentration (HP:0011016)2.85042785
48Focal segmental glomerulosclerosis (HP:0000097)2.84989690
49Progressive hearing impairment (HP:0001730)2.78534770
50Abnormality of the 1st metacarpal (HP:0010009)2.77089553
51Abnormality of vitamin metabolism (HP:0100508)2.73314539
52Hyperammonemia (HP:0001987)2.72520221
53Syncope (HP:0001279)2.65520965
54Atrophic scars (HP:0001075)2.64490063
55Cerebral palsy (HP:0100021)2.63281235
56Intrahepatic cholestasis (HP:0001406)2.62956029
57Micronodular cirrhosis (HP:0001413)2.62947771
58Metabolic alkalosis (HP:0200114)2.62534113
59Cheilitis (HP:0100825)2.61934300
60Palpitations (HP:0001962)2.60663068
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55883781
62Dicarboxylic aciduria (HP:0003215)2.55883781
63Hyperglycinuria (HP:0003108)2.52935463
64Ureteral stenosis (HP:0000071)2.51915491
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51760267
66Abnormality of the gastric mucosa (HP:0004295)2.51022838
67Fragile nails (HP:0001808)2.49852741
68Mildly elevated creatine phosphokinase (HP:0008180)2.45706624
69Abnormal tarsal ossification (HP:0008369)2.44631995
70Mesangial abnormality (HP:0001966)2.43531959
71Abnormality of chloride homeostasis (HP:0011422)2.41006085
72Abnormality of serine family amino acid metabolism (HP:0010894)2.40361153
73Abnormality of glycine metabolism (HP:0010895)2.40361153
74Abnormal biliary tract morphology (HP:0012440)2.39409365
75Alopecia of scalp (HP:0002293)2.39389446
76Hypotension (HP:0002615)2.39109245
77Complement deficiency (HP:0004431)2.38959917
78Glomerulosclerosis (HP:0000096)2.38714729
79Goiter (HP:0000853)2.36377942
80Potter facies (HP:0002009)2.34398127
81Facial shape deformation (HP:0011334)2.34398127
82Ureteral obstruction (HP:0006000)2.32696581
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.32196056
84Confusion (HP:0001289)2.29398013
85Abnormality of complement system (HP:0005339)2.28637230
86Xanthomatosis (HP:0000991)2.26507867
87Fragile skin (HP:0001030)2.26406734
88Thin bony cortex (HP:0002753)2.26127503
89Increased IgE level (HP:0003212)2.25647010
90Glomerulonephritis (HP:0000099)2.24672711
91Abnormality of purine metabolism (HP:0004352)2.22955516
92Hyperparathyroidism (HP:0000843)2.22531863
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.22262681
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22158395
95Nephrolithiasis (HP:0000787)2.20967030
96Onycholysis (HP:0001806)2.20102421
97Increased purine levels (HP:0004368)2.18563645
98Hyperuricemia (HP:0002149)2.18563645
99Curly hair (HP:0002212)2.17964743
100Metabolic acidosis (HP:0001942)2.17803541
101Abnormality of pyrimidine metabolism (HP:0004353)2.17282877
102Short phalanx of the thumb (HP:0009660)2.16858989
103Tongue fasciculations (HP:0001308)2.16409828
104Plantar hyperkeratosis (HP:0007556)2.16021930
105Abnormality of the nasal mucosa (HP:0000433)2.14598758
106Flattened epiphyses (HP:0003071)2.13610494
107Proximal tubulopathy (HP:0000114)2.13567001
108Abnormality of sodium homeostasis (HP:0010931)2.13554356
109Delayed CNS myelination (HP:0002188)2.13403546
110Late onset (HP:0003584)2.12756323
111Adrenal overactivity (HP:0002717)2.09575089
112Increased mean platelet volume (HP:0011877)2.08561465
113Hypercholesterolemia (HP:0003124)2.07707334
114Polycythemia (HP:0001901)2.07068891
115Cone-rod dystrophy (HP:0000548)2.07052458
116Eczematoid dermatitis (HP:0000976)2.06621817
117Abnormal hair laboratory examination (HP:0003328)2.05860001
118Abnormality of sulfur amino acid metabolism (HP:0004339)2.04441166
119Abnormality of carpal bone ossification (HP:0006257)2.02931086
120Bundle branch block (HP:0011710)2.01874474
121Chronic bronchitis (HP:0004469)2.00961932
122Steatorrhea (HP:0002570)1.98414437
123Abnormality of nucleobase metabolism (HP:0010932)1.97383218
124Nephritis (HP:0000123)1.97146141
125Severe combined immunodeficiency (HP:0004430)1.96537980
126Combined immunodeficiency (HP:0005387)1.96157595
127Ventricular tachycardia (HP:0004756)1.95952639
128Abnormality of B cell number (HP:0010975)1.95728743
129B lymphocytopenia (HP:0010976)1.95728743
130Reticulocytosis (HP:0001923)1.94843495
131Progressive sensorineural hearing impairment (HP:0000408)1.93849265
132Hyperphosphaturia (HP:0003109)1.92124066
133Abnormal foot bone ossification (HP:0010675)1.91070856
134Abnormal glucose tolerance (HP:0001952)1.90352099
135Biliary tract neoplasm (HP:0100574)1.90070318
136Hypoalbuminemia (HP:0003073)1.89667045
137Abnormal albumin level (HP:0012116)1.89667045
138Prolonged QT interval (HP:0001657)1.89289706
139Muscle fibrillation (HP:0010546)1.87446473
140Abnormal hand bone ossification (HP:0010660)1.87434106
141Vascular calcification (HP:0004934)1.86073195
142Pancreatitis (HP:0001733)1.85055175
143Growth hormone excess (HP:0000845)1.83326641
144Hyperphosphatemia (HP:0002905)1.82134491
145Ankle clonus (HP:0011448)1.80079894
146Hypophosphatemia (HP:0002148)1.78811219
147Renal salt wasting (HP:0000127)1.76248035
148Nasal polyposis (HP:0100582)1.76117696
149Protuberant abdomen (HP:0001538)1.75605757
150Enlarged epiphyses (HP:0010580)1.75402222
151Chronic otitis media (HP:0000389)1.70894356
152Elevated erythrocyte sedimentation rate (HP:0003565)1.70737633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.92782681
2EIF2AK15.08189930
3LMTK24.87380158
4MST44.75081738
5ACVR1B4.58888830
6MST1R3.99142502
7NME13.28306665
8PRKG23.10059824
9MAP2K22.60643910
10MAP3K92.53360769
11GRK62.48950992
12MAP2K62.34906285
13EPHA22.17982382
14EPHB22.01812969
15PTK61.95861224
16WNK41.95368511
17PIK3CA1.89984430
18MAP3K21.75171255
19TLK11.73995620
20TESK11.70882296
21RIPK11.65513737
22EPHA31.61921633
23KSR21.60984005
24ERN11.58549496
25MAP3K101.52789618
26TAOK11.43606698
27AKT31.39948761
28ARAF1.36427852
29TTK1.35055443
30NUAK11.33366483
31IRAK11.28418839
32MET1.27693074
33TBK11.26826161
34STK101.13506101
35MYLK1.06740871
36MAP3K81.05772838
37TAOK31.01329295
38TESK20.95985559
39MAP2K10.93729394
40SIK10.90521295
41PRKCI0.88835549
42MAP3K130.85938970
43PTK20.82148821
44BLK0.81975622
45DDR20.80901983
46ERBB20.79337245
47LATS10.78531869
48RIPK40.77963620
49PBK0.71570498
50CAMK2D0.71356121
51MATK0.70810528
52PRKAA20.66019984
53TEC0.65084529
54FER0.63995101
55MAP3K10.63574207
56IRAK20.63311966
57FGFR30.63163878
58MAP4K10.63100874
59PDPK10.61671308
60EPHA40.60815217
61CASK0.60776527
62MAP3K110.60336754
63MAP3K70.58405638
64BRAF0.56402307
65PIM20.56136096
66EPHB10.55638986
67LIMK10.55535189
68ABL20.55327357
69TYK20.54498020
70PHKG20.54264556
71PHKG10.54264556
72CDC42BPA0.53454782
73ERBB40.52807644
74MAPK110.52777147
75FGFR40.50734090
76PAK40.49971989
77CHUK0.48675878
78AURKB0.47726980
79IKBKE0.47716664
80MAP3K140.47537686
81CAMK2B0.47399121
82DYRK1B0.47075109
83BMX0.45799639
84CAMK2G0.42620404
85RPS6KB20.42344602
86PAK10.40477084
87NLK0.39511316
88MELK0.39011910
89PRKCA0.38322892
90TNIK0.36530768
91MAP3K60.35075367
92PDK10.34715077
93PINK10.34441727
94STK240.33463424
95MAPKAPK20.32280296
96IKBKB0.31772763
97PRKCZ0.30885343
98PRKAA10.30780406
99CSK0.29853536
100EEF2K0.28407004
101SRC0.26676073
102MAP3K50.23853928
103IRAK40.23515150
104ADRBK20.23494209
105DMPK0.22556708
106ROCK10.21691225
107STK390.21585445
108PRKCQ0.20820441
109MAPKAPK30.20751191
110CSNK1A10.20268855
111MAP3K30.19868673
112LRRK20.19361035
113PAK30.19239860
114RAF10.19181935
115MAP3K120.19117687
116IGF1R0.18245431
117PRKACG0.17264012
118KSR10.17213010
119CDK190.16559144
120GRK10.16326872
121PDK20.15640704
122SCYL20.14878867
123DAPK20.14350799
124RET0.13889589
125OXSR10.13770785
126STK30.13375041
127IRAK30.13139125
128AKT20.12605630
129PRKCE0.12174383
130JAK10.11692687
131FYN0.11675195
132CSF1R0.11351683
133PRKCB0.10801043
134PRKCD0.10208950
135ZAP700.10086176
136CDK90.09952730
137PRPF4B0.09452899
138GRK50.08874254
139LYN0.07533885
140JAK20.07455911

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.75512049
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.79019116
3Mineral absorption_Homo sapiens_hsa049784.08961525
4Renin-angiotensin system_Homo sapiens_hsa046143.78383104
5Vitamin digestion and absorption_Homo sapiens_hsa049773.47166385
6Sulfur metabolism_Homo sapiens_hsa009203.40105007
7Caffeine metabolism_Homo sapiens_hsa002322.62631398
8Galactose metabolism_Homo sapiens_hsa000522.59843088
9Bile secretion_Homo sapiens_hsa049762.24525195
10Starch and sucrose metabolism_Homo sapiens_hsa005002.20981192
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17946486
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.17568231
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.06011221
14Histidine metabolism_Homo sapiens_hsa003402.03974091
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02896009
16Protein digestion and absorption_Homo sapiens_hsa049742.01650703
17Fructose and mannose metabolism_Homo sapiens_hsa000511.93708719
18Folate biosynthesis_Homo sapiens_hsa007901.71218330
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.59919161
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56345433
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52795971
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47927679
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47217880
24Glutathione metabolism_Homo sapiens_hsa004801.38285844
25Linoleic acid metabolism_Homo sapiens_hsa005911.35291431
26Tryptophan metabolism_Homo sapiens_hsa003801.32109995
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29581056
28PPAR signaling pathway_Homo sapiens_hsa033201.27092945
29Glycerolipid metabolism_Homo sapiens_hsa005611.22464885
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19985886
31Arginine and proline metabolism_Homo sapiens_hsa003301.19588086
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11356575
33Thyroid hormone synthesis_Homo sapiens_hsa049181.02455847
34Sphingolipid metabolism_Homo sapiens_hsa006001.00593730
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99209119
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.97665160
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95835094
38Arachidonic acid metabolism_Homo sapiens_hsa005900.94630779
39Fatty acid degradation_Homo sapiens_hsa000710.94596661
40Sulfur relay system_Homo sapiens_hsa041220.93955167
41Pancreatic secretion_Homo sapiens_hsa049720.90165055
42Asthma_Homo sapiens_hsa053100.90063502
43Other glycan degradation_Homo sapiens_hsa005110.85228298
44Arginine biosynthesis_Homo sapiens_hsa002200.84954455
45Tight junction_Homo sapiens_hsa045300.84139974
46ABC transporters_Homo sapiens_hsa020100.82640758
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.81335889
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.77903159
49Staphylococcus aureus infection_Homo sapiens_hsa051500.77285706
50Pyruvate metabolism_Homo sapiens_hsa006200.76015120
51Pentose phosphate pathway_Homo sapiens_hsa000300.75560180
52Fatty acid metabolism_Homo sapiens_hsa012120.74547977
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74166248
54Propanoate metabolism_Homo sapiens_hsa006400.73075011
55Allograft rejection_Homo sapiens_hsa053300.72819605
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.69646196
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68446223
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68033906
59Ether lipid metabolism_Homo sapiens_hsa005650.67349418
60Graft-versus-host disease_Homo sapiens_hsa053320.66803678
61Hepatitis C_Homo sapiens_hsa051600.66111535
62Autoimmune thyroid disease_Homo sapiens_hsa053200.65089235
63Tyrosine metabolism_Homo sapiens_hsa003500.64294997
64Salmonella infection_Homo sapiens_hsa051320.63201697
65Retinol metabolism_Homo sapiens_hsa008300.62966481
66beta-Alanine metabolism_Homo sapiens_hsa004100.59378124
67Chemical carcinogenesis_Homo sapiens_hsa052040.56858729
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.56530355
69Nitrogen metabolism_Homo sapiens_hsa009100.56475875
70Complement and coagulation cascades_Homo sapiens_hsa046100.54143083
71Type I diabetes mellitus_Homo sapiens_hsa049400.53817293
72Butanoate metabolism_Homo sapiens_hsa006500.52034563
73Carbon metabolism_Homo sapiens_hsa012000.50944653
74African trypanosomiasis_Homo sapiens_hsa051430.47257829
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45385853
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.45218693
77Alzheimers disease_Homo sapiens_hsa050100.44804835
78Gastric acid secretion_Homo sapiens_hsa049710.44114382
79Salivary secretion_Homo sapiens_hsa049700.43739276
80Fatty acid biosynthesis_Homo sapiens_hsa000610.42480234
81Systemic lupus erythematosus_Homo sapiens_hsa053220.42043827
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41401117
83Oxidative phosphorylation_Homo sapiens_hsa001900.39227276
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38999964
85Adherens junction_Homo sapiens_hsa045200.38862652
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.37232962
87Parkinsons disease_Homo sapiens_hsa050120.35137808
88Steroid biosynthesis_Homo sapiens_hsa001000.34749776
89Insulin resistance_Homo sapiens_hsa049310.34564636
90Thyroid cancer_Homo sapiens_hsa052160.33771898
91Fatty acid elongation_Homo sapiens_hsa000620.32238661
92Bladder cancer_Homo sapiens_hsa052190.31874661
93GnRH signaling pathway_Homo sapiens_hsa049120.31606417
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31584180
95Metabolic pathways_Homo sapiens_hsa011000.29662232
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29479409
97Influenza A_Homo sapiens_hsa051640.29009206
98Pertussis_Homo sapiens_hsa051330.28790804
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28758037
100Renin secretion_Homo sapiens_hsa049240.27024314
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26620999
102Antigen processing and presentation_Homo sapiens_hsa046120.25633477
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21841144
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.21340745
105Biosynthesis of amino acids_Homo sapiens_hsa012300.20999545
106Type II diabetes mellitus_Homo sapiens_hsa049300.20028767
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19959640
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19790956
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18638312
110Insulin secretion_Homo sapiens_hsa049110.18042315
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16977053
112VEGF signaling pathway_Homo sapiens_hsa043700.14720192
113Vibrio cholerae infection_Homo sapiens_hsa051100.14689896
114Huntingtons disease_Homo sapiens_hsa050160.14326246
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13309395
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12357437
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11311526
118Leishmaniasis_Homo sapiens_hsa051400.10905219
119Cardiac muscle contraction_Homo sapiens_hsa042600.09902616
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09528296
121Selenocompound metabolism_Homo sapiens_hsa004500.09459024
122Peroxisome_Homo sapiens_hsa041460.09193087
123Phenylalanine metabolism_Homo sapiens_hsa003600.07552112
124Toxoplasmosis_Homo sapiens_hsa051450.06758273
125Glucagon signaling pathway_Homo sapiens_hsa049220.06698871
126TNF signaling pathway_Homo sapiens_hsa046680.05492119
127Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0156535

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