TRIM32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20456210
2synaptic vesicle exocytosis (GO:0016079)5.80575290
3synaptic vesicle maturation (GO:0016188)5.74586615
4vocalization behavior (GO:0071625)5.61366449
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51630093
6glutamate secretion (GO:0014047)5.45673933
7locomotory exploration behavior (GO:0035641)5.42658153
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40024007
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.33731024
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31678679
11regulation of synaptic vesicle exocytosis (GO:2000300)5.24976005
12protein localization to synapse (GO:0035418)5.02844742
13regulation of glutamate receptor signaling pathway (GO:1900449)4.96037780
14neuron cell-cell adhesion (GO:0007158)4.78538331
15neurotransmitter-gated ion channel clustering (GO:0072578)4.78174644
16regulation of synaptic vesicle transport (GO:1902803)4.64855594
17neurotransmitter secretion (GO:0007269)4.57448423
18positive regulation of synapse maturation (GO:0090129)4.54819404
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.52992853
20layer formation in cerebral cortex (GO:0021819)4.52216508
21exploration behavior (GO:0035640)4.52013122
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.38645611
23neuronal action potential propagation (GO:0019227)4.34557662
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.30412489
25regulation of neuronal synaptic plasticity (GO:0048168)4.29527787
26Golgi transport vesicle coating (GO:0048200)4.25037109
27COPI coating of Golgi vesicle (GO:0048205)4.25037109
28synaptic transmission, glutamatergic (GO:0035249)4.21574444
29regulation of synapse structural plasticity (GO:0051823)4.18146065
30glutamate receptor signaling pathway (GO:0007215)4.14719366
31neuron-neuron synaptic transmission (GO:0007270)4.10441285
32gamma-aminobutyric acid transport (GO:0015812)3.88541851
33neuron recognition (GO:0008038)3.87745284
34dendritic spine morphogenesis (GO:0060997)3.79864473
35long-term memory (GO:0007616)3.78335987
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76580768
37proline transport (GO:0015824)3.74571356
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.74406551
39postsynaptic membrane organization (GO:0001941)3.73317395
40establishment of integrated proviral latency (GO:0075713)3.72068567
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71219205
42axonal fasciculation (GO:0007413)3.69714622
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.66699192
44cellular potassium ion homeostasis (GO:0030007)3.65684689
45positive regulation of membrane potential (GO:0045838)3.65435402
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64474629
47synaptic vesicle endocytosis (GO:0048488)3.62918519
48neurotransmitter transport (GO:0006836)3.60656680
49long-term synaptic potentiation (GO:0060291)3.58530807
50regulation of synaptic plasticity (GO:0048167)3.57496876
51regulation of postsynaptic membrane potential (GO:0060078)3.57106594
52activation of protein kinase A activity (GO:0034199)3.53502609
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.51730140
54regulation of synapse maturation (GO:0090128)3.50885213
55regulation of dendritic spine morphogenesis (GO:0061001)3.50734346
56regulation of neurotransmitter secretion (GO:0046928)3.48774984
57cullin deneddylation (GO:0010388)3.47150122
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.45489826
59cerebellar granule cell differentiation (GO:0021707)3.44202616
60presynaptic membrane assembly (GO:0097105)3.42456332
61cerebellar Purkinje cell differentiation (GO:0021702)3.37462769
62positive regulation of mitochondrial fission (GO:0090141)3.36762809
63regulation of neurotransmitter levels (GO:0001505)3.34307751
64protein deneddylation (GO:0000338)3.32021147
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31972524
66auditory behavior (GO:0031223)3.30553739
67behavioral fear response (GO:0001662)3.29321071
68behavioral defense response (GO:0002209)3.29321071
69presynaptic membrane organization (GO:0097090)3.26210957
70dendrite morphogenesis (GO:0048813)3.25471425
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25349429
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.25312129
73neuromuscular process controlling balance (GO:0050885)3.24557985
74regulation of neurotransmitter transport (GO:0051588)3.23528725
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23040509
76response to pheromone (GO:0019236)3.22164624
77cell migration in hindbrain (GO:0021535)3.21844682
78sodium ion export (GO:0071436)3.21477775
79regulation of vesicle fusion (GO:0031338)3.17684777
80transmission of nerve impulse (GO:0019226)3.17684676
81positive regulation of neurotransmitter secretion (GO:0001956)3.17604722
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.17106439
83innervation (GO:0060384)3.16697605
84response to auditory stimulus (GO:0010996)3.16310575
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16143732
86positive regulation of neurotransmitter transport (GO:0051590)3.13291058
87synapse assembly (GO:0007416)3.11910784
88learning (GO:0007612)3.09545914
89negative regulation of chondrocyte differentiation (GO:0032331)3.08706854
90vesicle transport along microtubule (GO:0047496)3.06579619
91membrane depolarization (GO:0051899)3.05283614
92positive regulation of synaptic transmission (GO:0050806)3.04437186
93fear response (GO:0042596)3.04270383
94paraxial mesoderm development (GO:0048339)3.03927350
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03536355
96prepulse inhibition (GO:0060134)3.02910947
97membrane hyperpolarization (GO:0060081)3.02621717
98cell communication by electrical coupling (GO:0010644)3.02139407
99regulation of synaptic transmission (GO:0050804)3.01944930
100response to histamine (GO:0034776)3.00652204
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00150113
102establishment of viral latency (GO:0019043)3.00096228
103negative regulation of microtubule polymerization (GO:0031115)2.99874514
104synaptic transmission (GO:0007268)2.97052229
105neuromuscular process controlling posture (GO:0050884)2.97035604
106membrane depolarization during action potential (GO:0086010)2.96843993
107cerebellar Purkinje cell layer development (GO:0021680)2.95784542
108G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94725018
109regulation of dendritic spine development (GO:0060998)2.94259012
110kidney mesenchyme development (GO:0072074)2.91693773
111metanephric mesenchyme development (GO:0072075)2.91564303
112retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87870607
113fibroblast migration (GO:0010761)2.81497884
114mitotic nuclear envelope reassembly (GO:0007084)2.72877365
115nuclear envelope reassembly (GO:0031468)2.72877365
116peptidyl-arginine N-methylation (GO:0035246)2.60273193
117peptidyl-arginine methylation (GO:0018216)2.60273193
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53694210
119collagen fibril organization (GO:0030199)2.51624993
120protein retention in ER lumen (GO:0006621)2.46449933
121axon extension (GO:0048675)2.46153636
122positive regulation of male gonad development (GO:2000020)2.45909606
123ganglion development (GO:0061548)2.41248523
124type B pancreatic cell proliferation (GO:0044342)2.40249662
125neuron projection extension (GO:1990138)2.37947434
126cellular protein complex localization (GO:0034629)2.37652870
127mitochondrial fusion (GO:0008053)2.35760548
128vesicle coating (GO:0006901)2.32956052
129tRNA aminoacylation for protein translation (GO:0006418)2.32613375
130peptidyl-arginine omega-N-methylation (GO:0035247)2.30169102
131proximal/distal pattern formation (GO:0009954)2.29719126
132cell adhesion mediated by integrin (GO:0033627)2.26665583
133tRNA aminoacylation (GO:0043039)2.26207690
134amino acid activation (GO:0043038)2.26207690
135ventricular cardiac muscle cell development (GO:0055015)2.26161909
136muscle cell migration (GO:0014812)2.25923691
137neural crest cell development (GO:0014032)2.20899665
138polarized epithelial cell differentiation (GO:0030859)2.19444305
139protein complex localization (GO:0031503)2.19072569
140mitotic metaphase plate congression (GO:0007080)2.17165230
141positive regulation of actin filament depolymerization (GO:0030836)2.17103714
142axon extension involved in axon guidance (GO:0048846)2.16111289
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.16111289
144ephrin receptor signaling pathway (GO:0048013)2.14823108
145positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.14529812
146regulation of mitotic spindle organization (GO:0060236)2.14064771
147membrane budding (GO:0006900)2.13512738
148bone trabecula formation (GO:0060346)2.12394403
149protein hydroxylation (GO:0018126)2.11841137
150glycolytic process (GO:0006096)2.10810957
151skin morphogenesis (GO:0043589)2.06746941
152de novo posttranslational protein folding (GO:0051084)2.06698580
153generation of neurons (GO:0048699)2.06684193
154organ induction (GO:0001759)2.05050575
155diaphragm development (GO:0060539)2.03913903
156outer ear morphogenesis (GO:0042473)2.02839150
157eyelid development in camera-type eye (GO:0061029)2.02789785
158regulation of transforming growth factor beta2 production (GO:0032909)2.02651101
159intraciliary transport (GO:0042073)2.02399803
160hippo signaling (GO:0035329)2.02280507
161de novo protein folding (GO:0006458)2.02027289
162peptidyl-proline hydroxylation (GO:0019511)2.01775785
163glomerular basement membrane development (GO:0032836)2.01297566
164heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.00859755
165planar cell polarity pathway involved in neural tube closure (GO:0090179)2.00527400
166negative regulation of cartilage development (GO:0061037)1.99685436
167apical protein localization (GO:0045176)1.99448540
168regulation of cardioblast differentiation (GO:0051890)1.99196771
169hemidesmosome assembly (GO:0031581)1.98804584
170developmental cell growth (GO:0048588)1.98776311
171pyrimidine dimer repair (GO:0006290)1.96791041
172regulation of spindle organization (GO:0090224)1.96242655
173skeletal muscle organ development (GO:0060538)1.95681440
174chondrocyte proliferation (GO:0035988)1.95443849
175positive regulation of collagen biosynthetic process (GO:0032967)1.94609064
176adherens junction organization (GO:0034332)1.94252170
177COPII vesicle coating (GO:0048208)1.94019328
178positive regulation of protein targeting to membrane (GO:0090314)1.93621347
179G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.93495191
180regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.91544186
181negative regulation of JAK-STAT cascade (GO:0046426)1.90870697
182regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)1.90191714
183establishment of planar polarity (GO:0001736)1.89889385
184establishment of tissue polarity (GO:0007164)1.89889385
185asymmetric protein localization (GO:0008105)1.89889378
186embryonic cranial skeleton morphogenesis (GO:0048701)1.89778747
187lens morphogenesis in camera-type eye (GO:0002089)1.88447496
188regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.87733048
189positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)1.87054383
190regulation of sister chromatid cohesion (GO:0007063)1.86834829
191pyrimidine nucleobase catabolic process (GO:0006208)1.86643599
192regulation of translational fidelity (GO:0006450)1.86296854
193protein localization to microtubule (GO:0035372)1.86137282
194midgut development (GO:0007494)1.86062365
195regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.85133862
196mitochondrial fission (GO:0000266)1.84812829
197regulation of male gonad development (GO:2000018)1.84380626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17738991
2GBX2_23144817_ChIP-Seq_PC3_Human3.78197124
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25746695
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15586018
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15197560
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04783689
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81068867
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81068867
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.80642985
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.73822475
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72740164
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67654780
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65117885
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.64245072
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61448850
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56296794
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.55444267
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54170761
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50714290
20DROSHA_22980978_ChIP-Seq_HELA_Human2.44699195
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.38334432
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.37803666
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37749531
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36645596
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.31006160
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29914790
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.28309642
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.27835889
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25049718
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22678873
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22384742
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18109681
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15881877
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08117688
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.04254820
36* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99958989
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99900629
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.98328516
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98203083
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97706284
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96052942
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.95818573
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93572709
44AR_21572438_ChIP-Seq_LNCaP_Human1.91020068
45* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83309147
46ZNF263_19887448_ChIP-Seq_K562_Human1.82868637
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.81514327
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81381975
49DCP1A_22483619_ChIP-Seq_HELA_Human1.80312715
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80142653
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78320504
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78047136
53TAF15_26573619_Chip-Seq_HEK293_Human1.77538308
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75123751
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.74833553
56AR_21909140_ChIP-Seq_LNCAP_Human1.74085321
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68095345
58* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67661851
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66383804
60SMAD4_21799915_ChIP-Seq_A2780_Human1.64009282
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63140649
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.61953646
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.61828046
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57587207
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57531910
66ZNF274_21170338_ChIP-Seq_K562_Hela1.55465823
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48429185
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47954249
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45519775
70GABP_19822575_ChIP-Seq_HepG2_Human1.44896095
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44570373
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44409933
73* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43919510
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43591192
75ELK1_19687146_ChIP-ChIP_HELA_Human1.42768322
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40842884
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40281559
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40040873
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39155675
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39066081
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.38968665
82* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38769463
83* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38711284
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38678425
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.38026967
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.37693627
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37364380
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.37055568
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36166213
90P300_19829295_ChIP-Seq_ESCs_Human1.35256366
91XRN2_22483619_ChIP-Seq_HELA_Human1.35002984
92* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32921854
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32793907
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32283029
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.31773335
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30624780
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.29770233
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28910230
99* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28377227
100IGF1R_20145208_ChIP-Seq_DFB_Human1.27834412
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.27454065
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25906639
103AR_25329375_ChIP-Seq_VCAP_Human1.25720319
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.25636262
105AR_19668381_ChIP-Seq_PC3_Human1.25297019
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23157742
107* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22842105
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22270176
109BRD4_25478319_ChIP-Seq_HGPS_Human1.21472225
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21278130
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.21000162
112CLOCK_20551151_ChIP-Seq_293T_Human1.20742986
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20469862
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19972187
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18105397
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17794501
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17427052
118STAT3_23295773_ChIP-Seq_U87_Human1.17172245
119NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16906327
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16798832
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16113820
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15512393
123* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14506359
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14370313
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13693053
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13674842
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13085579
128RNF2_27304074_Chip-Seq_NSC_Mouse1.13029517
129TTF2_22483619_ChIP-Seq_HELA_Human1.12829360
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12689496
131YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12259015
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11306864
133E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10699083
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.10414768
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09792619
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09039282
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08436216
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07943543
139TP53_18474530_ChIP-ChIP_U2OS_Human1.07694291
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06578890
141SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04994830
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04899778
143ARNT_22903824_ChIP-Seq_MCF-7_Human1.04565234
144YY1_21170310_ChIP-Seq_MESCs_Mouse1.04555201
145TCF4_23295773_ChIP-Seq_U87_Human1.04016262
146PIAS1_25552417_ChIP-Seq_VCAP_Human1.03767146
147EP300_21415370_ChIP-Seq_HL-1_Mouse1.03259933
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00960767
149* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00622402
150* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00622402
151KDM2B_26808549_Chip-Seq_K562_Human1.00538834
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00171873
153* NANOG_21062744_ChIP-ChIP_HESCs_Human0.98910931
154AHR_22903824_ChIP-Seq_MCF-7_Human0.98341772
155RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98125957
156EOMES_21245162_ChIP-Seq_HESCs_Human0.97936672
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97271993
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.96555089
159MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96529241
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96389911
161TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96177950
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95894208
163FUS_26573619_Chip-Seq_HEK293_Human0.95399279
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95206994
165E2F7_22180533_ChIP-Seq_HELA_Human0.94616078
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.94083372
167POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93764794
168* JUN_21703547_ChIP-Seq_K562_Human0.93412798
169POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92991748
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.92723321
171RUNX2_22187159_ChIP-Seq_PCA_Human0.92244739
172GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92236192
173TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92153592
174TFEB_21752829_ChIP-Seq_HELA_Human0.90334936
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89614534
176* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89515643
177MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89390121
178VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88433953
179NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87317671
180UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86302888
181TET1_21490601_ChIP-Seq_MESCs_Mouse0.86022580
182* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85780854
183ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85703461
184TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83903156
185RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83134246
186SOX9_26525672_Chip-Seq_HEART_Mouse0.82175571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.47644756
2MP0003880_abnormal_central_pattern4.80774613
3MP0003635_abnormal_synaptic_transmissio4.18609914
4MP0008438_abnormal_cutaneous_collagen3.79764950
5MP0004270_analgesia3.58270657
6MP0002063_abnormal_learning/memory/cond3.42996694
7MP0009745_abnormal_behavioral_response3.38945618
8MP0009046_muscle_twitch3.17550380
9MP0002064_seizures3.15397904
10MP0001968_abnormal_touch/_nociception2.99977013
11MP0002822_catalepsy2.99053064
12MP0002572_abnormal_emotion/affect_behav2.82873829
13MP0005423_abnormal_somatic_nervous2.63346513
14MP0004272_abnormal_basement_membrane2.63043903
15MP0002734_abnormal_mechanical_nocicepti2.61580852
16MP0002272_abnormal_nervous_system2.49033648
17MP0001486_abnormal_startle_reflex2.43984073
18MP0002736_abnormal_nociception_after2.39496415
19MP0005257_abnormal_intraocular_pressure2.39478198
20MP0010030_abnormal_orbit_morphology2.32474577
21MP0005171_absent_coat_pigmentation2.31905253
22MP0002735_abnormal_chemical_nociception2.24797295
23MP0005503_abnormal_tendon_morphology2.18754539
24MP0000778_abnormal_nervous_system2.04638080
25MP0005275_abnormal_skin_tensile2.03783418
26MP0009780_abnormal_chondrocyte_physiolo2.01942297
27MP0002733_abnormal_thermal_nociception2.01619994
28MP0001440_abnormal_grooming_behavior2.01252146
29MP0001501_abnormal_sleep_pattern2.01111134
30MP0002067_abnormal_sensory_capabilities2.00518362
31MP0003941_abnormal_skin_development1.98873396
32MP0003950_abnormal_plasma_membrane1.97430929
33MP0002184_abnormal_innervation1.96615732
34MP0004811_abnormal_neuron_physiology1.90757371
35MP0008569_lethality_at_weaning1.90730964
36MP0001970_abnormal_pain_threshold1.90351446
37MP0003385_abnormal_body_wall1.87633926
38MP0002557_abnormal_social/conspecific_i1.83719882
39MP0000537_abnormal_urethra_morphology1.83237532
40MP0003122_maternal_imprinting1.82420950
41MP0002102_abnormal_ear_morphology1.82022253
42MP0003787_abnormal_imprinting1.80045578
43MP0005386_behavior/neurological_phenoty1.76751765
44MP0004924_abnormal_behavior1.76751765
45MP0003329_amyloid_beta_deposits1.76739379
46MP0008789_abnormal_olfactory_epithelium1.75773777
47MP0008932_abnormal_embryonic_tissue1.72935986
48MP0006276_abnormal_autonomic_nervous1.72703639
49MP0000749_muscle_degeneration1.71894377
50MP0000049_abnormal_middle_ear1.71320089
51MP0005646_abnormal_pituitary_gland1.67129591
52MP0004858_abnormal_nervous_system1.66760284
53MP0002909_abnormal_adrenal_gland1.65328628
54MP0002233_abnormal_nose_morphology1.64875030
55MP0000955_abnormal_spinal_cord1.61484999
56MP0001984_abnormal_olfaction1.57389973
57MP0003879_abnormal_hair_cell1.53435412
58MP0000762_abnormal_tongue_morphology1.51956451
59MP0003755_abnormal_palate_morphology1.51870553
60* MP0002882_abnormal_neuron_morphology1.46497874
61MP0003942_abnormal_urinary_system1.45027851
62MP0001529_abnormal_vocalization1.41272176
63* MP0002066_abnormal_motor_capabilities/c1.41248987
64MP0003937_abnormal_limbs/digits/tail_de1.39567022
65MP0003705_abnormal_hypodermis_morpholog1.37618194
66MP0003279_aneurysm1.33661288
67MP0003221_abnormal_cardiomyocyte_apopto1.33000795
68MP0009250_abnormal_appendicular_skeleto1.32129695
69MP0004885_abnormal_endolymph1.32114207
70MP0000733_abnormal_muscle_development1.31581121
71MP0009697_abnormal_copulation1.29909866
72MP0003693_abnormal_embryo_hatching1.25963698
73MP0001188_hyperpigmentation1.24902182
74MP0003566_abnormal_cell_adhesion1.23990079
75MP0009384_cardiac_valve_regurgitation1.23142520
76MP0005367_renal/urinary_system_phenotyp1.22835215
77MP0000516_abnormal_urinary_system1.22835215
78MP0002152_abnormal_brain_morphology1.22377392
79MP0005645_abnormal_hypothalamus_physiol1.21302127
80MP0002177_abnormal_outer_ear1.17896743
81MP0001502_abnormal_circadian_rhythm1.17229093
82MP0001905_abnormal_dopamine_level1.17196152
83MP0004142_abnormal_muscle_tone1.17085132
84MP0003633_abnormal_nervous_system1.16542501
85MP0003935_abnormal_craniofacial_develop1.15976999
86MP0010352_gastrointestinal_tract_polyps1.09618033
87MP0000750_abnormal_muscle_regeneration1.05760470
88MP0002108_abnormal_muscle_morphology1.05595041
89MP0001542_abnormal_bone_strength1.04874151
90MP0005508_abnormal_skeleton_morphology1.04860987
91MP0002938_white_spotting1.03914527
92MP0003631_nervous_system_phenotype1.03750948
93MP0005197_abnormal_uvea_morphology0.99902222
94MP0002249_abnormal_larynx_morphology0.99704479
95* MP0004233_abnormal_muscle_weight0.98818225
96* MP0000759_abnormal_skeletal_muscle0.98686564
97MP0003718_maternal_effect0.97365504
98MP0005499_abnormal_olfactory_system0.96963394
99MP0005394_taste/olfaction_phenotype0.96963394
100MP0002084_abnormal_developmental_patter0.96138519
101MP0000569_abnormal_digit_pigmentation0.96025315
102MP0002697_abnormal_eye_size0.95282738
103MP0008058_abnormal_DNA_repair0.94981099
104MP0002060_abnormal_skin_morphology0.94753097
105MP0004145_abnormal_muscle_electrophysio0.94735403
106MP0000767_abnormal_smooth_muscle0.93326390
107MP0003123_paternal_imprinting0.92840985
108MP0002085_abnormal_embryonic_tissue0.92246718
109MP0003111_abnormal_nucleus_morphology0.91953807
110MP0003077_abnormal_cell_cycle0.91355936
111MP0004957_abnormal_blastocyst_morpholog0.91152991
112MP0002069_abnormal_eating/drinking_beha0.91112804
113MP0010368_abnormal_lymphatic_system0.90931957
114MP0009053_abnormal_anal_canal0.90790782
115MP0002116_abnormal_craniofacial_bone0.90246337
116MP0005551_abnormal_eye_electrophysiolog0.89788595
117MP0002114_abnormal_axial_skeleton0.88252362
118MP0001177_atelectasis0.87931447
119MP0008872_abnormal_physiological_respon0.87705181
120MP0000631_abnormal_neuroendocrine_gland0.87664175
121MP0000428_abnormal_craniofacial_morphol0.87640805
122MP0002229_neurodegeneration0.87388892
123MP0004085_abnormal_heartbeat0.84123027
124MP0002282_abnormal_trachea_morphology0.83643588
125MP0005248_abnormal_Harderian_gland0.83585090
126MP0002269_muscular_atrophy0.83505193
127MP0000013_abnormal_adipose_tissue0.83083718
128MP0003121_genomic_imprinting0.82235034
129MP0000432_abnormal_head_morphology0.82227409
130MP0003634_abnormal_glial_cell0.81953903
131MP0002896_abnormal_bone_mineralization0.81795398
132MP0006054_spinal_hemorrhage0.81661219
133MP0003315_abnormal_perineum_morphology0.80982291
134MP0002752_abnormal_somatic_nervous0.80750683
135MP0003283_abnormal_digestive_organ0.78706342
136MP0002111_abnormal_tail_morphology0.78067556
137MP0003632_abnormal_nervous_system0.77587361
138MP0001963_abnormal_hearing_physiology0.77353042
139MP0000003_abnormal_adipose_tissue0.77333467
140MP0004197_abnormal_fetal_growth/weight/0.76900079
141MP0003861_abnormal_nervous_system0.76457785
142MP0002295_abnormal_pulmonary_circulatio0.75938404
143MP0008874_decreased_physiological_sensi0.75582550
144MP0003115_abnormal_respiratory_system0.75438832
145MP0004215_abnormal_myocardial_fiber0.75424142
146MP0000747_muscle_weakness0.75276808
147MP0002081_perinatal_lethality0.74559589
148MP0005187_abnormal_penis_morphology0.73677398
149MP0003137_abnormal_impulse_conducting0.73652396
150MP0010386_abnormal_urinary_bladder0.72955046
151MP0005623_abnormal_meninges_morphology0.72650464
152MP0001340_abnormal_eyelid_morphology0.72633964
153MP0002932_abnormal_joint_morphology0.72449633
154MP0005380_embryogenesis_phenotype0.71876394
155MP0001672_abnormal_embryogenesis/_devel0.71876394
156* MP0000751_myopathy0.71841156
157MP0008961_abnormal_basal_metabolism0.71819725
158MP0000579_abnormal_nail_morphology0.70789857
159MP0001730_embryonic_growth_arrest0.70385094
160MP0001286_abnormal_eye_development0.70349994
161MP0002837_dystrophic_cardiac_calcinosis0.69620328
162MP0004742_abnormal_vestibular_system0.69429988
163MP0003890_abnormal_embryonic-extraembry0.69387107
164MP0002090_abnormal_vision0.68464854
165MP0000604_amyloidosis0.67048482
166MP0001299_abnormal_eye_distance/0.66062132
167MP0004484_altered_response_of0.65986748
168MP0001943_abnormal_respiration0.62282993
169MP0001664_abnormal_digestion0.60429267
170MP0000534_abnormal_ureter_morphology0.59647836
171MP0005535_abnormal_body_temperature0.59539820
172MP0010769_abnormal_survival0.59215422
173MP0010770_preweaning_lethality0.58510265
174MP0002082_postnatal_lethality0.58510265
175MP0002653_abnormal_ependyma_morphology0.57844560
176MP0002638_abnormal_pupillary_reflex0.55435695
177MP0010768_mortality/aging0.55409440
178MP0008877_abnormal_DNA_methylation0.54802807
179MP0002751_abnormal_autonomic_nervous0.52187016
180MP0002234_abnormal_pharynx_morphology0.52022992
181* MP0003956_abnormal_body_size0.51367065

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.20858398
2Myokymia (HP:0002411)6.37143531
3Focal seizures (HP:0007359)5.42795168
4Epileptic encephalopathy (HP:0200134)5.04702130
5Visual hallucinations (HP:0002367)5.02444095
6Premature rupture of membranes (HP:0001788)4.67148200
7Atonic seizures (HP:0010819)4.51557194
8Febrile seizures (HP:0002373)4.16823006
9Progressive cerebellar ataxia (HP:0002073)4.00491495
10Absence seizures (HP:0002121)3.97466864
11Hyperventilation (HP:0002883)3.79743786
12Generalized tonic-clonic seizures (HP:0002069)3.59309525
13Dialeptic seizures (HP:0011146)3.57278084
14Broad-based gait (HP:0002136)3.55570694
15Action tremor (HP:0002345)3.55220171
16Poor eye contact (HP:0000817)3.34274998
17Ankle clonus (HP:0011448)3.32218322
18Depression (HP:0000716)3.22894519
19Supranuclear gaze palsy (HP:0000605)3.22543101
20Abnormality of the lower motor neuron (HP:0002366)3.18055228
21Impaired vibration sensation in the lower limbs (HP:0002166)3.16074362
22Abnormal social behavior (HP:0012433)3.10985925
23Impaired social interactions (HP:0000735)3.10985925
24Mutism (HP:0002300)3.05981854
25Protrusio acetabuli (HP:0003179)3.00429473
26Gaze-evoked nystagmus (HP:0000640)2.99904125
27Dysdiadochokinesis (HP:0002075)2.99788165
28Abnormal eating behavior (HP:0100738)2.99678618
29Excessive salivation (HP:0003781)2.99004065
30Drooling (HP:0002307)2.99004065
31Amblyopia (HP:0000646)2.96833993
32Truncal ataxia (HP:0002078)2.91241325
33Ankle contracture (HP:0006466)2.90351965
34* Shoulder girdle muscle weakness (HP:0003547)2.85900866
35Arterial tortuosity (HP:0005116)2.83695754
36Anxiety (HP:0000739)2.82603112
37Vascular tortuosity (HP:0004948)2.80254073
38Progressive inability to walk (HP:0002505)2.75591910
39Epileptiform EEG discharges (HP:0011182)2.75367411
40Urinary bladder sphincter dysfunction (HP:0002839)2.73219023
41Dysmetria (HP:0001310)2.64191980
42Urinary urgency (HP:0000012)2.64044370
43Postural instability (HP:0002172)2.61969185
44Limb dystonia (HP:0002451)2.61615018
45EEG with generalized epileptiform discharges (HP:0011198)2.61588371
46Scanning speech (HP:0002168)2.60950437
47Torticollis (HP:0000473)2.59565323
48Amyotrophic lateral sclerosis (HP:0007354)2.56346605
49Abnormality of dentin (HP:0010299)2.54321862
50Genetic anticipation (HP:0003743)2.52556931
51Pheochromocytoma (HP:0002666)2.50519586
52* Abnormality of the hip-girdle musculature (HP:0001445)2.50382645
53* Abnormality of the musculature of the pelvis (HP:0001469)2.50382645
54Impaired smooth pursuit (HP:0007772)2.49601556
55Polyphagia (HP:0002591)2.49412675
56Hypsarrhythmia (HP:0002521)2.49189556
57Papilledema (HP:0001085)2.47110384
58Aortic dissection (HP:0002647)2.46516334
59Short nail (HP:0001799)2.45361169
60Spastic gait (HP:0002064)2.44409971
61Focal dystonia (HP:0004373)2.42767147
62Unilateral renal agenesis (HP:0000122)2.41683661
63Microglossia (HP:0000171)2.40072049
64Abnormality of binocular vision (HP:0011514)2.39933581
65Diplopia (HP:0000651)2.39933581
66Dysmetric saccades (HP:0000641)2.39221632
67Termporal pattern (HP:0011008)2.38548423
68Insidious onset (HP:0003587)2.38548423
69Spinal rigidity (HP:0003306)2.37800561
70Absent speech (HP:0001344)2.37716428
71Exercise-induced muscle cramps (HP:0003710)2.37478880
72Stereotypic behavior (HP:0000733)2.36239746
73Bradykinesia (HP:0002067)2.35530391
74Atrophic scars (HP:0001075)2.35328372
75Hemiparesis (HP:0001269)2.35093973
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.33354289
77Inability to walk (HP:0002540)2.32889080
78Type 1 muscle fiber predominance (HP:0003803)2.32815298
79Cerebral inclusion bodies (HP:0100314)2.29953798
80Megalencephaly (HP:0001355)2.25595827
81* Limb-girdle muscle weakness (HP:0003325)2.24983953
82* Limb-girdle muscle atrophy (HP:0003797)2.22965680
83Hemiplegia (HP:0002301)2.22125021
84Agitation (HP:0000713)2.21932437
85Hydroureter (HP:0000072)2.21591589
86Fetal akinesia sequence (HP:0001989)2.21516934
87Shallow orbits (HP:0000586)2.20186137
88Abnormality of ocular smooth pursuit (HP:0000617)2.18633474
89Abnormality of the corticospinal tract (HP:0002492)2.17896757
90Craniofacial dystonia (HP:0012179)2.16693717
91Pointed chin (HP:0000307)2.15492961
92Hand muscle atrophy (HP:0009130)2.15327991
93Status epilepticus (HP:0002133)2.14634439
94Delayed gross motor development (HP:0002194)2.14102088
95Bladder diverticulum (HP:0000015)2.14064534
96Neuroendocrine neoplasm (HP:0100634)2.13780915
97Nemaline bodies (HP:0003798)2.10200439
98Lower limb muscle weakness (HP:0007340)2.07835346
99Hypoventilation (HP:0002791)2.07202719
100Neurofibrillary tangles (HP:0002185)2.06112242
101Annular pancreas (HP:0001734)2.04199583
102Abnormality of the phalanges of the hallux (HP:0010057)2.03578637
103Abnormality of the metopic suture (HP:0005556)2.02983483
104Impaired vibratory sensation (HP:0002495)2.02725471
105Intention tremor (HP:0002080)2.00671262
106Soft skin (HP:0000977)2.00612744
107Failure to thrive in infancy (HP:0001531)1.98013513
108Inappropriate behavior (HP:0000719)1.96542480
109Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96429760
110Gait ataxia (HP:0002066)1.95876332
111Entropion (HP:0000621)1.94280568
112Generalized myoclonic seizures (HP:0002123)1.93239499
113Insomnia (HP:0100785)1.91313704
114Incomplete penetrance (HP:0003829)1.91311416
115Aortic aneurysm (HP:0004942)1.90470014
116Neoplasm of the peripheral nervous system (HP:0100007)1.90082159
117Mildly elevated creatine phosphokinase (HP:0008180)1.89957353
118Muscle fiber inclusion bodies (HP:0100299)1.88483751
119Rimmed vacuoles (HP:0003805)1.87657111
120Delusions (HP:0000746)1.87187296
121Blue irides (HP:0000635)1.87067237
122Obstructive sleep apnea (HP:0002870)1.85641482
123Papillary thyroid carcinoma (HP:0002895)1.85560986
124Ventricular fibrillation (HP:0001663)1.85135255
125Prominent metopic ridge (HP:0005487)1.85069580
126Protruding tongue (HP:0010808)1.84643544
127Abnormality of salivation (HP:0100755)1.84538234
128Right ventricular cardiomyopathy (HP:0011663)1.84306487
129Neuronal loss in central nervous system (HP:0002529)1.84028418
130Reduced subcutaneous adipose tissue (HP:0003758)1.83836223
131Hypoplastic pelvis (HP:0008839)1.83106129
132Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82710385
133Hypoplasia of the brainstem (HP:0002365)1.82710385
134Osteolytic defects of the hand bones (HP:0009699)1.81603635
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.81603635
136* Abnormality of the shoulder girdle musculature (HP:0001435)1.81285973
137Sleep apnea (HP:0010535)1.81121189
138Wormian bones (HP:0002645)1.80598358
139Abnormality of the labia minora (HP:0012880)1.79490108
140Follicular hyperkeratosis (HP:0007502)1.79461192
141Upper limb amyotrophy (HP:0009129)1.79061172
142Distal upper limb amyotrophy (HP:0007149)1.79061172
143Hyperthyroidism (HP:0000836)1.78954625
144Narrow nasal bridge (HP:0000446)1.78373819
145Clonus (HP:0002169)1.78235982
146Abnormality of the distal phalanges of the toes (HP:0010182)1.78212812
147Abnormality of glycolysis (HP:0004366)1.77957201
148* Specific learning disability (HP:0001328)1.77063496
149Resting tremor (HP:0002322)1.76016279
150Slender build (HP:0001533)1.72536927
151* Abnormality of the calf musculature (HP:0001430)1.72365583
152Scapular winging (HP:0003691)1.71320153
153Fragile skin (HP:0001030)1.70210304
154* Pelvic girdle muscle weakness (HP:0003749)1.70015020
155High anterior hairline (HP:0009890)1.67721197
156Natal tooth (HP:0000695)1.67254723
157Cholecystitis (HP:0001082)1.66756347
158Abnormal gallbladder physiology (HP:0012438)1.66756347
159Atrophy/Degeneration involving motor neurons (HP:0007373)1.62947551
160Hypoplastic left heart (HP:0004383)1.62317473
161Calcaneovalgus deformity (HP:0001848)1.59460927
162Cortical dysplasia (HP:0002539)1.58860363
163Hypoplasia of the iris (HP:0007676)1.58047679
164Deformed tarsal bones (HP:0008119)1.56879069
165Upper limb muscle weakness (HP:0003484)1.56437578
166Elbow flexion contracture (HP:0002987)1.56109011
167Short clavicles (HP:0000894)1.55765019
168Ulnar bowing (HP:0003031)1.54526106
169Increased serum pyruvate (HP:0003542)1.51702312
170Hammertoe (HP:0001765)1.51160790
171Upper motor neuron abnormality (HP:0002127)1.50568271
172Aplasia/Hypoplasia of the clavicles (HP:0006710)1.49760085
173Broad metatarsal (HP:0001783)1.48771936
174Bowel diverticulosis (HP:0005222)1.48188173
175Increased connective tissue (HP:0009025)1.46908115
176Postnatal microcephaly (HP:0005484)1.45804965
177Vertebral compression fractures (HP:0002953)1.45308964
178Abnormality of the umbilical cord (HP:0010881)1.44191877
179Heterochromia iridis (HP:0001100)1.44021541
180Decreased lacrimation (HP:0000633)1.43870236
181Proximal placement of thumb (HP:0009623)1.43603607
182Proximal amyotrophy (HP:0007126)1.43355757
183Pterygium (HP:0001059)1.43335567
184Morphological abnormality of the middle ear (HP:0008609)1.42063061
185Aplasia of the musculature (HP:0100854)1.41768631
186Myelomeningocele (HP:0002475)1.40715788
187* Dental crowding (HP:0000678)1.40693073
188Trismus (HP:0000211)1.39069615
189Male infertility (HP:0003251)1.38786565
190Long clavicles (HP:0000890)1.38480670
191Hyperacusis (HP:0010780)1.37817880
192Neonatal short-limb short stature (HP:0008921)1.36640664
193Glossoptosis (HP:0000162)1.36260315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.17318835
2EPHA44.08389574
3MAP3K93.64924873
4MARK13.64860026
5TRIM283.38047150
6MAP3K43.20878827
7CASK2.82839232
8MINK12.82333505
9MAP2K72.66707711
10DAPK22.49031698
11SRPK12.34389543
12TESK12.25308272
13PAK62.24775907
14NTRK22.19969366
15LIMK12.08448791
16MAP3K122.07252313
17EIF2AK12.05898669
18CSNK1G31.98785242
19CSNK1A1L1.95279300
20KSR11.94804677
21MAP2K41.93859656
22KSR21.93576549
23PRKD31.80629893
24PLK21.79594499
25NEK91.77436953
26EPHA21.75169776
27CAMKK11.73505655
28DAPK11.69347747
29CDK191.66716195
30CSNK1G11.62866719
31PDGFRA1.61399744
32NTRK11.60730859
33PTK21.59138256
34CDK51.52790443
35MET1.52211031
36VRK21.47466105
37MAPK131.46743812
38PAK41.40252046
39EIF2AK31.38939327
40STK161.37510258
41MYLK1.36509224
42PRPF4B1.33050537
43PHKG11.29972021
44PHKG21.29972021
45LATS21.29835745
46ERBB41.26907298
47GRK51.26161306
48TSSK61.25084339
49MST1R1.22997450
50PRKCG1.22361566
51CAMKK21.20845974
52LATS11.20212856
53EPHB21.19115109
54BCKDK1.18933914
55TYRO31.17811276
56PIM21.16576925
57BUB11.16556093
58RPS6KA41.16249367
59STK381.15844837
60SIK21.13414164
61RIPK41.13060265
62UHMK11.11965274
63CDK181.10754686
64PAK21.10443380
65ARAF1.09051383
66STK38L1.08258314
67CDK151.05857763
68CDK141.05463930
69BRSK21.04679007
70AURKA1.01394640
71TESK21.00017246
72TTN0.97583911
73TIE10.97301964
74TNIK0.96658855
75SGK2230.94905962
76SGK4940.94905962
77PNCK0.93903528
78CDK11A0.91839215
79NEK10.91685694
80CAMK2A0.91102305
81CCNB10.87460788
82DDR20.86584041
83TAOK10.86226325
84FES0.85664319
85LMTK20.83785428
86SGK20.82097814
87PLK10.81912344
88SIK30.79240134
89RET0.77262721
90WNK30.76858688
91RAF10.76631289
92PAK30.76429394
93CSNK1G20.75612872
94DYRK1A0.75507789
95STK110.75499580
96BRD40.74688990
97CAMK2B0.74388517
98PRKCH0.73232122
99CAMK10.72197737
100OXSR10.72080304
101TTK0.71437598
102ABL20.71091784
103DYRK1B0.70824142
104MAP3K130.70709067
105OBSCN0.70228174
106MAP3K20.69061003
107PTK2B0.68376230
108SGK30.67882484
109EPHB10.67711552
110SCYL20.67479086
111MOS0.64799914
112ALK0.61861099
113CDC70.60101254
114AURKB0.59942923
115PRKD20.58885365
116SGK10.58857672
117FLT30.58597728
118MARK20.57035836
119AKT30.55587084
120PBK0.55035351
121CDK120.55011483
122FER0.54484670
123PRKCZ0.51129781
124DYRK30.48499339
125ERBB30.48278503
126PDK10.47703234
127PRKCE0.47674360
128PLK30.47566500
129BCR0.47298268
130PINK10.46147656
131RPS6KA30.44829400
132CDK70.43159642
133MAP2K10.43156256
134PDPK10.42481612
135CDK80.42297300
136EPHA30.42212630
137MAP3K60.41855805
138DAPK30.40289475
139EIF2AK20.40205589
140RIPK10.39664014
141MAP3K50.39657294
142NME10.39179346
143BRAF0.38893753
144AKT20.38758930
145FYN0.38637843
146BMPR20.38596250
147CAMK2D0.37702190
148CDK90.37571651
149CAMK40.37065952
150MAPK100.36795371
151DYRK20.36644973
152CSNK1D0.36303560
153ROCK20.35390019
154CAMK2G0.34642002
155RPS6KA20.34283960
156MAP3K10.33556885
157TNK20.32252485
158BRSK10.32161142
159FGFR20.31094278

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79535667
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62362512
3GABAergic synapse_Homo sapiens_hsa047272.77784996
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71869629
5Circadian entrainment_Homo sapiens_hsa047132.68442881
6Olfactory transduction_Homo sapiens_hsa047402.63405010
7Long-term potentiation_Homo sapiens_hsa047202.60411802
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58742189
9Morphine addiction_Homo sapiens_hsa050322.49900713
10Glutamatergic synapse_Homo sapiens_hsa047242.49315921
11Amphetamine addiction_Homo sapiens_hsa050312.42146018
12Dopaminergic synapse_Homo sapiens_hsa047282.25002698
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24380171
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21960183
15Salivary secretion_Homo sapiens_hsa049702.03588205
16Insulin secretion_Homo sapiens_hsa049111.93107205
17Cholinergic synapse_Homo sapiens_hsa047251.86680037
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79263706
19Gastric acid secretion_Homo sapiens_hsa049711.76302206
20Long-term depression_Homo sapiens_hsa047301.74253595
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73549303
22Taste transduction_Homo sapiens_hsa047421.72179848
23Collecting duct acid secretion_Homo sapiens_hsa049661.71125639
24Hippo signaling pathway_Homo sapiens_hsa043901.69726028
25Biosynthesis of amino acids_Homo sapiens_hsa012301.68798524
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66179631
27Cocaine addiction_Homo sapiens_hsa050301.65944003
28Renin secretion_Homo sapiens_hsa049241.63310024
29Oxytocin signaling pathway_Homo sapiens_hsa049211.62775292
30Serotonergic synapse_Homo sapiens_hsa047261.58668757
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57363633
32Nucleotide excision repair_Homo sapiens_hsa034201.55454063
33Steroid biosynthesis_Homo sapiens_hsa001001.54015483
34Gap junction_Homo sapiens_hsa045401.49505742
35Calcium signaling pathway_Homo sapiens_hsa040201.46464483
36Fatty acid elongation_Homo sapiens_hsa000621.45507599
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44737875
38Non-homologous end-joining_Homo sapiens_hsa034501.44387469
39GnRH signaling pathway_Homo sapiens_hsa049121.39371260
40Adherens junction_Homo sapiens_hsa045201.38815178
41Proteasome_Homo sapiens_hsa030501.37291132
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36891357
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35272931
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31904611
45Base excision repair_Homo sapiens_hsa034101.29157887
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26976383
47Cell cycle_Homo sapiens_hsa041101.26379071
48Basal cell carcinoma_Homo sapiens_hsa052171.25827998
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25463130
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24912980
51Sulfur relay system_Homo sapiens_hsa041221.24773786
52Axon guidance_Homo sapiens_hsa043601.24464690
53Mismatch repair_Homo sapiens_hsa034301.21687750
54Carbon metabolism_Homo sapiens_hsa012001.21160042
55cAMP signaling pathway_Homo sapiens_hsa040241.19858686
56Pyruvate metabolism_Homo sapiens_hsa006201.19812221
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19647104
58Protein export_Homo sapiens_hsa030601.18459909
59Estrogen signaling pathway_Homo sapiens_hsa049151.18354488
60Glioma_Homo sapiens_hsa052141.17004689
61RNA transport_Homo sapiens_hsa030131.16880669
62N-Glycan biosynthesis_Homo sapiens_hsa005101.15725512
63TGF-beta signaling pathway_Homo sapiens_hsa043501.15325622
64Vibrio cholerae infection_Homo sapiens_hsa051101.15059592
65Folate biosynthesis_Homo sapiens_hsa007901.14649995
66Hedgehog signaling pathway_Homo sapiens_hsa043401.12959065
67ECM-receptor interaction_Homo sapiens_hsa045121.12750871
68Basal transcription factors_Homo sapiens_hsa030221.10548298
69* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10039953
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09558530
71ErbB signaling pathway_Homo sapiens_hsa040121.08541666
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08250258
73Type II diabetes mellitus_Homo sapiens_hsa049301.06117971
74Oocyte meiosis_Homo sapiens_hsa041141.05152303
75Melanogenesis_Homo sapiens_hsa049161.04673892
76Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03443656
77Focal adhesion_Homo sapiens_hsa045101.00979210
78cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00770160
79DNA replication_Homo sapiens_hsa030300.99799056
80Vitamin B6 metabolism_Homo sapiens_hsa007500.98179390
81Galactose metabolism_Homo sapiens_hsa000520.95319105
82Spliceosome_Homo sapiens_hsa030400.94252672
83Pentose phosphate pathway_Homo sapiens_hsa000300.94012154
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93795866
85Thyroid cancer_Homo sapiens_hsa052160.93132550
86RNA polymerase_Homo sapiens_hsa030200.92360597
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90663299
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89318949
89Tight junction_Homo sapiens_hsa045300.88846376
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.88271850
91AMPK signaling pathway_Homo sapiens_hsa041520.85298444
92Cardiac muscle contraction_Homo sapiens_hsa042600.85009374
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.84232475
94mRNA surveillance pathway_Homo sapiens_hsa030150.83896603
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83274233
96p53 signaling pathway_Homo sapiens_hsa041150.79308891
97Pyrimidine metabolism_Homo sapiens_hsa002400.79269911
98Fructose and mannose metabolism_Homo sapiens_hsa000510.79156085
99Propanoate metabolism_Homo sapiens_hsa006400.77011782
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.76930709
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.75078354
102Phototransduction_Homo sapiens_hsa047440.74631669
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73562183
104Proteoglycans in cancer_Homo sapiens_hsa052050.72431617
105Sulfur metabolism_Homo sapiens_hsa009200.72408450
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72405600
107Huntingtons disease_Homo sapiens_hsa050160.72112222
108Dilated cardiomyopathy_Homo sapiens_hsa054140.71207041
109Thyroid hormone synthesis_Homo sapiens_hsa049180.70242989
110MAPK signaling pathway_Homo sapiens_hsa040100.69454262
111Dorso-ventral axis formation_Homo sapiens_hsa043200.68948172
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68796454
113RNA degradation_Homo sapiens_hsa030180.67988749
114Arginine and proline metabolism_Homo sapiens_hsa003300.67925855
115Choline metabolism in cancer_Homo sapiens_hsa052310.67051901
116Pancreatic secretion_Homo sapiens_hsa049720.65918159
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65807303
118Endometrial cancer_Homo sapiens_hsa052130.63929009
119Glucagon signaling pathway_Homo sapiens_hsa049220.62922035
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62770170
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61789126
122Alcoholism_Homo sapiens_hsa050340.61380407
123mTOR signaling pathway_Homo sapiens_hsa041500.60960521
124Shigellosis_Homo sapiens_hsa051310.59842657
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59367061
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58873635
127VEGF signaling pathway_Homo sapiens_hsa043700.58868890
128Protein digestion and absorption_Homo sapiens_hsa049740.58405310
129Glutathione metabolism_Homo sapiens_hsa004800.58284486
130Ras signaling pathway_Homo sapiens_hsa040140.57244217
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57177757
132Rap1 signaling pathway_Homo sapiens_hsa040150.56230867
133Purine metabolism_Homo sapiens_hsa002300.54530682
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54497536
135Selenocompound metabolism_Homo sapiens_hsa004500.54441038
136MicroRNAs in cancer_Homo sapiens_hsa052060.53109728
137Colorectal cancer_Homo sapiens_hsa052100.52110457
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51701644
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51401338
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51295149
141Melanoma_Homo sapiens_hsa052180.51060429
142Wnt signaling pathway_Homo sapiens_hsa043100.50421913
143Non-small cell lung cancer_Homo sapiens_hsa052230.50196085
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49282022
145Fanconi anemia pathway_Homo sapiens_hsa034600.48684891
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.48611710
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47564649
148Renal cell carcinoma_Homo sapiens_hsa052110.47296205
149Endocytosis_Homo sapiens_hsa041440.47008493
150Small cell lung cancer_Homo sapiens_hsa052220.46909134
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46625077
152Insulin signaling pathway_Homo sapiens_hsa049100.46380629
153Type I diabetes mellitus_Homo sapiens_hsa049400.46183774
154Circadian rhythm_Homo sapiens_hsa047100.45301270
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44807771
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44643637
157Regulation of autophagy_Homo sapiens_hsa041400.44045230
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43873712
159Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43447364
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41843091
161Nitrogen metabolism_Homo sapiens_hsa009100.41060187
162Inositol phosphate metabolism_Homo sapiens_hsa005620.40000813
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.36486426
164Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35234811
165Prion diseases_Homo sapiens_hsa050200.33057649
166Ovarian steroidogenesis_Homo sapiens_hsa049130.30544455
167Bile secretion_Homo sapiens_hsa049760.30400434
168Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29508191
169Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29400141
170Alzheimers disease_Homo sapiens_hsa050100.24871472
171SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24527578

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