TRIM33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.71409617
2mitotic sister chromatid cohesion (GO:0007064)5.39629559
3nuclear pore organization (GO:0006999)5.28907182
4pre-miRNA processing (GO:0031054)4.76674094
5regulation of RNA export from nucleus (GO:0046831)4.50429670
6pore complex assembly (GO:0046931)4.40563060
7regulation of establishment of cell polarity (GO:2000114)4.06944415
8negative regulation of histone methylation (GO:0031061)3.91440650
9regulation of histone H3-K27 methylation (GO:0061085)3.86104308
10monoubiquitinated protein deubiquitination (GO:0035520)3.79159139
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77030822
12regulation of DNA endoreduplication (GO:0032875)3.73216638
13regulation of histone H3-K9 methylation (GO:0051570)3.58371445
14regulation of nucleobase-containing compound transport (GO:0032239)3.56724225
15histone H3-K4 trimethylation (GO:0080182)3.55580146
16regulation of histone H3-K4 methylation (GO:0051569)3.54215523
17regulation of establishment or maintenance of cell polarity (GO:0032878)3.49271083
18histone H2A monoubiquitination (GO:0035518)3.48623998
19peptidyl-lysine trimethylation (GO:0018023)3.45516283
20sister chromatid segregation (GO:0000819)3.39296299
21embryonic camera-type eye morphogenesis (GO:0048596)3.37572944
22intestinal epithelial cell development (GO:0060576)3.35604444
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33198718
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.31614033
25regulation of DNA methylation (GO:0044030)3.29696717
26sister chromatid cohesion (GO:0007062)3.29414421
27cytoplasmic mRNA processing body assembly (GO:0033962)3.26382486
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.23709486
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23709486
30positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23709486
31positive regulation of histone H3-K4 methylation (GO:0051571)3.22692247
32kinetochore organization (GO:0051383)3.20851276
33protein localization to kinetochore (GO:0034501)3.20575091
34embryonic retina morphogenesis in camera-type eye (GO:0060059)3.18822229
35negative regulation of DNA repair (GO:0045738)3.18116132
36regulation of sister chromatid cohesion (GO:0007063)3.11733426
37regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.08961621
38microtubule depolymerization (GO:0007019)3.08855615
39TOR signaling (GO:0031929)3.06121562
40regulation of centriole replication (GO:0046599)3.06099279
41histone H3-K9 demethylation (GO:0033169)3.05162963
42mitotic nuclear envelope disassembly (GO:0007077)3.04083620
43NLS-bearing protein import into nucleus (GO:0006607)3.03082002
44prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.02523960
45negative regulation of translation, ncRNA-mediated (GO:0040033)3.02099655
46regulation of translation, ncRNA-mediated (GO:0045974)3.02099655
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.02099655
48regulation of telomere maintenance via telomerase (GO:0032210)2.97569089
49positive regulation of chromosome segregation (GO:0051984)2.97346604
50mitotic metaphase plate congression (GO:0007080)2.97043592
51nuclear envelope disassembly (GO:0051081)2.93438107
52membrane disassembly (GO:0030397)2.93438107
53glucocorticoid receptor signaling pathway (GO:0042921)2.92893077
54histone H3-K36 demethylation (GO:0070544)2.92849487
55mitotic chromosome condensation (GO:0007076)2.91508867
56meiotic chromosome segregation (GO:0045132)2.91236456
57DNA methylation (GO:0006306)2.88930695
58DNA alkylation (GO:0006305)2.88930695
59chromatin assembly (GO:0031497)2.88377067
60histone H4-K16 acetylation (GO:0043984)2.87917799
61DNA unwinding involved in DNA replication (GO:0006268)2.87386247
62histone H3-K9 methylation (GO:0051567)2.87257564
63histone H3-K4 methylation (GO:0051568)2.86031443
64mitotic sister chromatid segregation (GO:0000070)2.86010721
65gene silencing by RNA (GO:0031047)2.85594748
66DNA topological change (GO:0006265)2.85142760
67centriole replication (GO:0007099)2.84111659
68metaphase plate congression (GO:0051310)2.83078437
69peptidyl-lysine methylation (GO:0018022)2.82917880
70dosage compensation (GO:0007549)2.80459034
71protein localization to chromosome, centromeric region (GO:0071459)2.79022658
72positive regulation of histone methylation (GO:0031062)2.78895279
73ATP-dependent chromatin remodeling (GO:0043044)2.78778645
74histone lysine methylation (GO:0034968)2.78423855
75DNA duplex unwinding (GO:0032508)2.77794277
76DNA geometric change (GO:0032392)2.77378491
77regulation of spindle organization (GO:0090224)2.77100775
78regulation of chromosome segregation (GO:0051983)2.76035629
79spindle assembly involved in mitosis (GO:0090307)2.74645209
80protein localization to chromosome (GO:0034502)2.74008585
81hepatocyte apoptotic process (GO:0097284)2.71691045
82oocyte development (GO:0048599)2.69589251
83attachment of spindle microtubules to kinetochore (GO:0008608)2.69233098
84regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69065709
85negative regulation of histone modification (GO:0031057)2.68562963
86regulation of meiosis I (GO:0060631)2.68562364
87centrosome duplication (GO:0051298)2.67586140
88histone H2A acetylation (GO:0043968)2.67569055
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.66759631
90peptidyl-threonine dephosphorylation (GO:0035970)2.66602045
91histone lysine demethylation (GO:0070076)2.66561188
92microtubule anchoring (GO:0034453)2.66454816
93microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.65667237
94chromatin assembly or disassembly (GO:0006333)2.65226360
95negative regulation of DNA-dependent DNA replication (GO:2000104)2.65157174
96cardiac right ventricle morphogenesis (GO:0003215)2.65105578
97N-terminal protein amino acid acetylation (GO:0006474)2.62682756
98prostate gland growth (GO:0060736)2.62589184
99kinetochore assembly (GO:0051382)2.62374555
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62295684
101regulation of mitotic sister chromatid separation (GO:0010965)2.61802751
102regulation of mitotic sister chromatid segregation (GO:0033047)2.61802751
103regulation of sister chromatid segregation (GO:0033045)2.61802751
104heterochromatin organization (GO:0070828)2.60454741
105positive regulation of mRNA 3-end processing (GO:0031442)2.60379946
106spindle checkpoint (GO:0031577)2.60288842
107resolution of meiotic recombination intermediates (GO:0000712)2.60094727
108mRNA splice site selection (GO:0006376)2.59319916
109mRNA transport (GO:0051028)2.58867399
110histone demethylation (GO:0016577)2.58386895
111regulation of centrosome cycle (GO:0046605)2.57782511
112regulation of mRNA 3-end processing (GO:0031440)2.57100522
113interkinetic nuclear migration (GO:0022027)2.56925132
114corticosteroid receptor signaling pathway (GO:0031958)2.56575231
115histone-serine phosphorylation (GO:0035404)2.56416988
116positive regulation by host of viral transcription (GO:0043923)2.56320285
117negative regulation of chromatin modification (GO:1903309)2.56076938
118nucleosome disassembly (GO:0006337)2.55928059
119protein-DNA complex disassembly (GO:0032986)2.55928059
120DNA replication-dependent nucleosome organization (GO:0034723)2.55781174
121DNA replication-dependent nucleosome assembly (GO:0006335)2.55781174
122DNA replication-independent nucleosome assembly (GO:0006336)2.55622621
123DNA replication-independent nucleosome organization (GO:0034724)2.55622621
124DNA synthesis involved in DNA repair (GO:0000731)2.54929984
125DNA replication checkpoint (GO:0000076)2.54702091
126embryonic eye morphogenesis (GO:0048048)2.52773178
127nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52718628
128spindle assembly checkpoint (GO:0071173)2.52651787
129synapsis (GO:0007129)2.52616911
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.52478158
131negative regulation of chromosome segregation (GO:0051985)2.51827591
132ear development (GO:0043583)2.51540359
133regulation of centrosome duplication (GO:0010824)2.51197920
134regulation of histone methylation (GO:0031060)2.50429721
135meiotic cell cycle (GO:0051321)2.49628166
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.49266859
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49266859
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49266859
139negative regulation of sister chromatid segregation (GO:0033046)2.49266859
140mitotic spindle checkpoint (GO:0071174)2.48936721
141positive regulation of DNA-templated transcription, initiation (GO:2000144)2.48817390
142regulation of telomere maintenance (GO:0032204)2.48623267
143establishment of chromosome localization (GO:0051303)2.48588731
144negative regulation of fibroblast apoptotic process (GO:2000270)2.47600225
145stress granule assembly (GO:0034063)2.47200602
146positive regulation of cell cycle G2/M phase transition (GO:1902751)2.45976092
147positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.45976092
148protein K48-linked deubiquitination (GO:0071108)2.41226918
149positive regulation of mRNA processing (GO:0050685)2.41073355
150regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.40872436
151positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.40872436
152negative regulation of organelle assembly (GO:1902116)2.40385707
153histone methylation (GO:0016571)2.40034764
154nucleus organization (GO:0006997)2.39696677
155DNA conformation change (GO:0071103)2.38616297
156regulation of DNA-dependent DNA replication (GO:0090329)2.38131571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45262174
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75440148
3* SALL1_21062744_ChIP-ChIP_HESCs_Human4.00841573
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71360141
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.67124650
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.56848838
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.50326586
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.46290106
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.91907377
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66750396
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66209534
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52135653
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.36542628
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30259215
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25640517
16* ER_23166858_ChIP-Seq_MCF-7_Human2.21472208
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.15799303
18AHR_22903824_ChIP-Seq_MCF-7_Human2.08228468
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.03912327
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.00552671
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.99125464
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.95254155
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92404047
24TAF15_26573619_Chip-Seq_HEK293_Human1.78535973
25* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74583002
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72219424
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70019746
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69306255
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66704817
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66704817
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66704817
32FUS_26573619_Chip-Seq_HEK293_Human1.64344048
33* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.62221654
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61915930
35MYC_22102868_ChIP-Seq_BL_Human1.61386111
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57611802
37AR_21909140_ChIP-Seq_LNCAP_Human1.52892143
38GBX2_23144817_ChIP-Seq_PC3_Human1.52607702
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51836565
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50817577
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45243600
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.45150600
43* EWS_26573619_Chip-Seq_HEK293_Human1.43926732
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43067548
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39299636
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.37627817
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37544914
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37285101
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36335769
50IGF1R_20145208_ChIP-Seq_DFB_Human1.34844570
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33957029
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.33042345
53* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31675711
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28796201
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27885529
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27270316
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26630153
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26255526
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25431700
60EZH2_22144423_ChIP-Seq_EOC_Human1.23735314
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22233080
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21614404
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.19745438
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19399553
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18333676
66AR_21572438_ChIP-Seq_LNCaP_Human1.18230562
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.17955862
68GATA1_22025678_ChIP-Seq_K562_Human1.16990159
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.16922167
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16883643
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.16504896
72* SMAD4_21799915_ChIP-Seq_A2780_Human1.14371541
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13256961
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.13020648
75* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09030121
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08833960
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08606996
78P300_19829295_ChIP-Seq_ESCs_Human1.06626399
79CIITA_25753668_ChIP-Seq_RAJI_Human1.05545514
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04376355
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04319523
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04199758
83* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03938187
84* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03012524
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01409963
86* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01385487
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01276795
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00360877
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.00082625
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00061733
91* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99805986
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.99656858
93ELK1_19687146_ChIP-ChIP_HELA_Human0.99267045
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98880877
95* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97654599
96CBX2_27304074_Chip-Seq_ESCs_Mouse0.96653838
97* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95876690
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.95641707
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95552862
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94643696
101* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94239963
102* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94228132
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94094921
104TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94067599
105TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93361403
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93093546
107* CHD1_26751641_Chip-Seq_LNCaP_Human0.93041366
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92553074
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92553074
110TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91505513
111KDM5A_27292631_Chip-Seq_BREAST_Human0.90789516
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90505808
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.89051878
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88083089
115CBP_20019798_ChIP-Seq_JUKART_Human0.88083089
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88036697
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.87060899
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86652456
119* SOX9_26525672_Chip-Seq_HEART_Mouse0.86626058
120BRD4_25478319_ChIP-Seq_HGPS_Human0.84707246
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83101361
122* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82686087
123STAT3_23295773_ChIP-Seq_U87_Human0.81511533
124IRF1_19129219_ChIP-ChIP_H3396_Human0.81213593
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81089748
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.79942841
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78392974
128* TCF7_22412390_ChIP-Seq_EML_Mouse0.78287883
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77961083
130TCF4_23295773_ChIP-Seq_U87_Human0.76342905
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.76199792
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75981201
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.74696124
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.74501504
135RNF2_27304074_Chip-Seq_NSC_Mouse0.74259262
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.73898333
137WDR5_24793694_ChIP-Seq_LNCAP_Human0.72083587
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71586212
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71047850
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.70764325
141ZNF274_21170338_ChIP-Seq_K562_Hela0.70619573
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70518641
143* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.70324580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.42063523
2MP0000569_abnormal_digit_pigmentation3.38989217
3MP0010094_abnormal_chromosome_stability2.88735503
4MP0008877_abnormal_DNA_methylation2.75283977
5MP0003111_abnormal_nucleus_morphology2.60550380
6MP0003121_genomic_imprinting2.55475920
7MP0003787_abnormal_imprinting2.54964151
8MP0003123_paternal_imprinting2.45665991
9MP0003077_abnormal_cell_cycle2.33518513
10MP0000537_abnormal_urethra_morphology2.30388558
11MP0004957_abnormal_blastocyst_morpholog2.14808273
12MP0005076_abnormal_cell_differentiation2.14425876
13MP0003693_abnormal_embryo_hatching2.11823382
14MP0008058_abnormal_DNA_repair2.04126306
15* MP0003890_abnormal_embryonic-extraembry2.03116329
16MP0010352_gastrointestinal_tract_polyps2.02919300
17MP0005646_abnormal_pituitary_gland1.96883120
18MP0000427_abnormal_hair_cycle1.94834402
19* MP0002084_abnormal_developmental_patter1.86729768
20MP0001730_embryonic_growth_arrest1.73931693
21MP0002009_preneoplasia1.72760500
22MP0010307_abnormal_tumor_latency1.69940830
23MP0003119_abnormal_digestive_system1.69934983
24MP0004197_abnormal_fetal_growth/weight/1.69604648
25MP0000350_abnormal_cell_proliferation1.69131339
26MP0004381_abnormal_hair_follicle1.67190361
27MP0005187_abnormal_penis_morphology1.64173480
28* MP0001672_abnormal_embryogenesis/_devel1.62678851
29* MP0005380_embryogenesis_phenotype1.62678851
30MP0001293_anophthalmia1.61838111
31* MP0002085_abnormal_embryonic_tissue1.61050687
32MP0008007_abnormal_cellular_replicative1.61012421
33MP0003937_abnormal_limbs/digits/tail_de1.55247997
34MP0006292_abnormal_olfactory_placode1.54661238
35* MP0003984_embryonic_growth_retardation1.50127111
36MP0009053_abnormal_anal_canal1.48422334
37MP0004264_abnormal_extraembryonic_tissu1.48268176
38MP0002160_abnormal_reproductive_system1.48026532
39* MP0002088_abnormal_embryonic_growth/wei1.47060132
40MP0009703_decreased_birth_body1.45566771
41MP0003122_maternal_imprinting1.44919010
42* MP0002086_abnormal_extraembryonic_tissu1.42376357
43MP0003861_abnormal_nervous_system1.41826548
44MP0003718_maternal_effect1.40382478
45* MP0001697_abnormal_embryo_size1.39806420
46MP0003935_abnormal_craniofacial_develop1.39342379
47MP0005367_renal/urinary_system_phenotyp1.37399179
48MP0000516_abnormal_urinary_system1.37399179
49MP0005248_abnormal_Harderian_gland1.35811040
50MP0000778_abnormal_nervous_system1.31160894
51MP0005075_abnormal_melanosome_morpholog1.29999243
52MP0009780_abnormal_chondrocyte_physiolo1.28403225
53MP0002653_abnormal_ependyma_morphology1.27450997
54MP0000566_synostosis1.24303761
55MP0002098_abnormal_vibrissa_morphology1.23562201
56MP0005409_darkened_coat_color1.23435336
57MP0000428_abnormal_craniofacial_morphol1.23429829
58MP0002210_abnormal_sex_determination1.22330267
59MP0003943_abnormal_hepatobiliary_system1.21665380
60MP0004808_abnormal_hematopoietic_stem1.20557058
61MP0005408_hypopigmentation1.20370565
62MP0009672_abnormal_birth_weight1.17761877
63MP0005499_abnormal_olfactory_system1.16216941
64MP0005394_taste/olfaction_phenotype1.16216941
65MP0001286_abnormal_eye_development1.16134068
66MP0000432_abnormal_head_morphology1.14948912
67MP0003936_abnormal_reproductive_system1.13885803
68MP0002396_abnormal_hematopoietic_system1.13665828
69MP0000647_abnormal_sebaceous_gland1.13546952
70MP0003755_abnormal_palate_morphology1.13459367
71MP0003315_abnormal_perineum_morphology1.13131372
72MP0009697_abnormal_copulation1.12947298
73MP0008789_abnormal_olfactory_epithelium1.12655435
74* MP0002080_prenatal_lethality1.12316822
75MP0010234_abnormal_vibrissa_follicle1.11033679
76MP0003115_abnormal_respiratory_system1.10169823
77MP0002938_white_spotting1.09757712
78MP0003567_abnormal_fetal_cardiomyocyte1.09674986
79MP0008932_abnormal_embryonic_tissue1.09569478
80MP0003942_abnormal_urinary_system1.08677929
81MP0000377_abnormal_hair_follicle1.07488499
82MP0001929_abnormal_gametogenesis1.06095416
83MP0001145_abnormal_male_reproductive1.04506068
84MP0002751_abnormal_autonomic_nervous1.04285131
85MP0003786_premature_aging1.02772957
86MP0003385_abnormal_body_wall1.02462838
87MP0010678_abnormal_skin_adnexa1.00524942
88MP0001919_abnormal_reproductive_system0.98310019
89MP0000383_abnormal_hair_follicle0.97699491
90MP0004859_abnormal_synaptic_plasticity0.97580434
91MP0005623_abnormal_meninges_morphology0.97120028
92MP0002233_abnormal_nose_morphology0.95674097
93MP0002184_abnormal_innervation0.95665083
94MP0010030_abnormal_orbit_morphology0.95497276
95MP0002116_abnormal_craniofacial_bone0.94139324
96MP0008995_early_reproductive_senescence0.93417301
97MP0000627_abnormal_mammary_gland0.92457473
98MP0000653_abnormal_sex_gland0.92246706
99MP0002092_abnormal_eye_morphology0.91560912
100MP0004233_abnormal_muscle_weight0.91330059
101MP0000733_abnormal_muscle_development0.90979044
102MP0002095_abnormal_skin_pigmentation0.89910666
103MP0003698_abnormal_male_reproductive0.88988318
104MP0002796_impaired_skin_barrier0.88797676
105MP0002925_abnormal_cardiovascular_devel0.88222946
106MP0002081_perinatal_lethality0.88196266
107MP0002152_abnormal_brain_morphology0.86726538
108MP0005389_reproductive_system_phenotype0.86720185
109MP0003699_abnormal_female_reproductive0.86587054
110MP0003705_abnormal_hypodermis_morpholog0.84551330
111MP0002111_abnormal_tail_morphology0.83493567
112MP0001188_hyperpigmentation0.83487155
113MP0004185_abnormal_adipocyte_glucose0.83335253
114MP0003941_abnormal_skin_development0.83096727
115MP0000015_abnormal_ear_pigmentation0.82373743
116MP0002114_abnormal_axial_skeleton0.80063632
117MP0002697_abnormal_eye_size0.78100419
118MP0001119_abnormal_female_reproductive0.76578282
119MP0001849_ear_inflammation0.75111819
120MP0000703_abnormal_thymus_morphology0.74438512
121MP0000631_abnormal_neuroendocrine_gland0.74378387
122MP0002177_abnormal_outer_ear0.72304026
123MP0001340_abnormal_eyelid_morphology0.71686600
124MP0003136_yellow_coat_color0.71652461
125MP0000470_abnormal_stomach_morphology0.70983020
126MP0000313_abnormal_cell_death0.70316775
127MP0004742_abnormal_vestibular_system0.69240510
128MP0002877_abnormal_melanocyte_morpholog0.68561416
129MP0003938_abnormal_ear_development0.68317911
130MP0005174_abnormal_tail_pigmentation0.67899511
131MP0005391_vision/eye_phenotype0.67842596
132MP0002109_abnormal_limb_morphology0.66961489
133MP0002102_abnormal_ear_morphology0.66888798

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.33524203
2Short 4th metacarpal (HP:0010044)3.17825716
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.17825716
4Asymmetry of the thorax (HP:0001555)3.06614451
5Colon cancer (HP:0003003)2.82622718
6Astrocytoma (HP:0009592)2.77857314
7Abnormality of the astrocytes (HP:0100707)2.77857314
8Increased nuchal translucency (HP:0010880)2.77416321
9Septate vagina (HP:0001153)2.75789395
10Medulloblastoma (HP:0002885)2.72221153
11Curly hair (HP:0002212)2.70054655
12Abnormality of the labia minora (HP:0012880)2.66013152
13Acute lymphatic leukemia (HP:0006721)2.65992802
14Abnormality of the fingertips (HP:0001211)2.61537616
15Meckel diverticulum (HP:0002245)2.61276850
16Neoplasm of the oral cavity (HP:0100649)2.53393679
17Abnormality of the ileum (HP:0001549)2.51855574
18Abnormality of the preputium (HP:0100587)2.46369412
19* Thyroid carcinoma (HP:0002890)2.45699395
20Ectopic kidney (HP:0000086)2.44858337
21Glioma (HP:0009733)2.43370906
22Ependymoma (HP:0002888)2.41455234
23Acute myeloid leukemia (HP:0004808)2.38473653
24* Papillary thyroid carcinoma (HP:0002895)2.37548178
25Embryonal neoplasm (HP:0002898)2.31464244
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.30595300
27Diastasis recti (HP:0001540)2.30426575
28Facial hemangioma (HP:0000329)2.23791458
29Hypoplastic labia majora (HP:0000059)2.18151252
30Obsessive-compulsive behavior (HP:0000722)2.17527487
31Germ cell neoplasia (HP:0100728)2.16752367
32Proximal placement of thumb (HP:0009623)2.15332694
33Deviation of the thumb (HP:0009603)2.13998926
34Long eyelashes (HP:0000527)2.12616626
35Deep philtrum (HP:0002002)2.12422825
36Neoplasm of the adrenal cortex (HP:0100641)2.12272069
37Microglossia (HP:0000171)2.11795662
38Abnormality of the 4th metacarpal (HP:0010012)2.11614598
39Birth length less than 3rd percentile (HP:0003561)2.11100344
40Clubbing of toes (HP:0100760)2.09980971
41Truncal obesity (HP:0001956)2.09261414
42High anterior hairline (HP:0009890)2.08628901
43Supernumerary ribs (HP:0005815)2.06233942
44Renal duplication (HP:0000075)2.05360828
45Chromsome breakage (HP:0040012)2.04470040
46Breast carcinoma (HP:0003002)2.03595031
47Cystic hygroma (HP:0000476)2.03112655
48Subacute progressive viral hepatitis (HP:0006572)2.02359059
49Abnormality of the nasal septum (HP:0000419)2.01292439
50Abnormality of the septum pellucidum (HP:0007375)1.99985188
51Trigonocephaly (HP:0000243)1.99976248
52Oligodactyly (hands) (HP:0001180)1.99255181
53Hepatoblastoma (HP:0002884)1.99140646
54Macroorchidism (HP:0000053)1.98913493
55Absent eyebrow (HP:0002223)1.98617102
56Cafe-au-lait spot (HP:0000957)1.98344196
57Abnormal lung lobation (HP:0002101)1.97652397
58Myelodysplasia (HP:0002863)1.97550410
59Absent frontal sinuses (HP:0002688)1.96883112
60Malignant gastrointestinal tract tumors (HP:0006749)1.96690763
61Gastrointestinal carcinoma (HP:0002672)1.96690763
62Absent radius (HP:0003974)1.96008213
63Heterotopia (HP:0002282)1.93973437
64Abnormal number of incisors (HP:0011064)1.91335128
65Abnormality of the labia majora (HP:0012881)1.91048368
66Impulsivity (HP:0100710)1.90241140
67Narrow palate (HP:0000189)1.88801379
68Oligodactyly (HP:0012165)1.88005120
69Transitional cell carcinoma of the bladder (HP:0006740)1.86874607
70Small intestinal stenosis (HP:0012848)1.86549685
71Duodenal stenosis (HP:0100867)1.86549685
72Triphalangeal thumb (HP:0001199)1.86531868
73Abnormal hair whorl (HP:0010721)1.83884837
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83102667
75Degeneration of the lateral corticospinal tracts (HP:0002314)1.83102667
76Absent forearm bone (HP:0003953)1.82139336
77Aplasia involving forearm bones (HP:0009822)1.82139336
78Overlapping toe (HP:0001845)1.81337568
79Rhabdomyosarcoma (HP:0002859)1.81098263
80Abnormality of the frontal sinuses (HP:0002687)1.80648814
81Supernumerary bones of the axial skeleton (HP:0009144)1.79999499
82Cutis marmorata (HP:0000965)1.79983519
83Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79865103
84Aqueductal stenosis (HP:0002410)1.79581797
85Protruding tongue (HP:0010808)1.79305034
86Broad thumb (HP:0011304)1.79147237
87Arteriovenous malformation (HP:0100026)1.78899202
88Hyperacusis (HP:0010780)1.78845219
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77996894
90Hamartoma (HP:0010566)1.77428423
91Biliary tract neoplasm (HP:0100574)1.77402933
92Renovascular hypertension (HP:0100817)1.77377384
93Nephroblastoma (Wilms tumor) (HP:0002667)1.76565282
94Neoplasm of striated muscle (HP:0009728)1.76530734
95Myelomeningocele (HP:0002475)1.76489567
96Abnormality of the duodenum (HP:0002246)1.76404062
97Abnormality of the lower motor neuron (HP:0002366)1.76114682
98Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75779651
99Genetic anticipation (HP:0003743)1.75294659
100Abnormality of chromosome segregation (HP:0002916)1.74308591
101Hyperventilation (HP:0002883)1.73853034
102Bladder neoplasm (HP:0009725)1.73080047
103Bladder carcinoma (HP:0002862)1.73080047
104Midline defect of the nose (HP:0004122)1.72905972
105Prominent nose (HP:0000448)1.72825767
106Patellar aplasia (HP:0006443)1.72768284
107Anal stenosis (HP:0002025)1.72448339
108Low anterior hairline (HP:0000294)1.72012162
109Missing ribs (HP:0000921)1.70130031
1102-3 toe syndactyly (HP:0004691)1.69008737
111Leiomyosarcoma (HP:0100243)1.68611113
112Uterine leiomyosarcoma (HP:0002891)1.68611113
113Fair hair (HP:0002286)1.67110046
114Increased number of teeth (HP:0011069)1.66998045
115Drooling (HP:0002307)1.66878975
116Embryonal renal neoplasm (HP:0011794)1.66812933
117Atresia of the external auditory canal (HP:0000413)1.66060507
118Abnormality of chromosome stability (HP:0003220)1.65100429
119Lip pit (HP:0100267)1.65056473
120Cupped ear (HP:0000378)1.65001325
121* Neoplasm of the thyroid gland (HP:0100031)1.64863529
122Partial agenesis of the corpus callosum (HP:0001338)1.64045287
123Meningioma (HP:0002858)1.63931591
124Skull defect (HP:0001362)1.63526748
125Hypoplasia of the maxilla (HP:0000327)1.61702906
126Amyotrophic lateral sclerosis (HP:0007354)1.61660414
127Sandal gap (HP:0001852)1.60183532
128Abnormality of the corticospinal tract (HP:0002492)1.60130568
129Abnormality of the diencephalon (HP:0010662)1.59523890
130Short thumb (HP:0009778)1.58265222
131Aplasia/Hypoplasia of the patella (HP:0006498)1.58106616
132Urethral obstruction (HP:0000796)1.57910752
133Choanal atresia (HP:0000453)1.57559855
134Overriding aorta (HP:0002623)1.57246317
135Abnormality of the carotid arteries (HP:0005344)1.57169080
136Elfin facies (HP:0004428)1.56970268
137Uterine neoplasm (HP:0010784)1.56951622
138Smooth philtrum (HP:0000319)1.56113341
139Shawl scrotum (HP:0000049)1.55356777
140Rectal prolapse (HP:0002035)1.54877028
141Spinal muscular atrophy (HP:0007269)1.54755508
142Basal cell carcinoma (HP:0002671)1.53305882
143Impaired smooth pursuit (HP:0007772)1.51529586
144Inappropriate behavior (HP:0000719)1.49769919
145Amaurosis fugax (HP:0100576)1.49724427
146Vesicoureteral reflux (HP:0000076)1.48126749
147Supernumerary spleens (HP:0009799)1.47483876
148Broad palm (HP:0001169)1.47268507
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.47004476
150Abnormality of ocular smooth pursuit (HP:0000617)1.46098618
151Broad phalanges of the hand (HP:0009768)1.45982786
152Labial hypoplasia (HP:0000066)1.45962070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.41304108
2CDC73.42189702
3AKT32.51126151
4PIK3CA2.49293420
5TAF12.32899117
6LATS12.31169154
7NEK22.27645604
8SRPK12.27359531
9MKNK12.25697437
10BRD42.24480567
11NEK62.20110678
12MKNK22.07478608
13PNCK2.07409694
14PKN21.77754604
15PLK31.72863414
16CASK1.72283078
17ERBB31.70057548
18MARK11.62181039
19WEE11.59247516
20FRK1.55989512
21FGFR21.53767383
22KSR11.53523917
23STK31.52869376
24TYRO31.49694482
25STK391.49076484
26CHEK21.48531479
27CHEK11.47086482
28NEK11.46793552
29ATR1.43608873
30MELK1.41539871
31TRIB31.39212937
32BRSK21.38524169
33TNIK1.35023214
34TSSK61.33549849
35CAMK1G1.30421364
36ACVR1B1.30409517
37ALK1.29540080
38PLK11.23774281
39ATM1.22402233
40TTK1.18101535
41PASK1.17977633
42MAP3K41.13882829
43CAMK1D1.12071635
44CDK61.11006521
45SGK21.08571972
46PLK41.07287899
47MAP3K101.05499484
48EIF2AK31.04400022
49CDK21.03966420
50CSNK1A1L1.01322920
51BRSK11.01251611
52ICK1.00756483
53EEF2K0.98669031
54MTOR0.98128265
55FGFR10.97428849
56TAOK20.97406367
57PLK20.97382777
58AURKB0.96920427
59WNK40.96513528
60NUAK10.95932398
61NLK0.95754750
62EIF2AK10.93923926
63PRKD30.91475086
64TAOK10.91361780
65STK38L0.91047652
66CDK10.89611903
67NTRK30.88925721
68FGFR30.88725993
69SGK30.87238981
70SGK4940.86720651
71SGK2230.86720651
72CDK40.85561246
73BMPR1B0.84596509
74CSNK1D0.81131534
75SCYL20.79071845
76EIF2AK20.79002231
77DYRK30.78937776
78RET0.78420334
79CDK90.77463769
80CDK70.76261666
81LATS20.76190274
82PBK0.75968443
83PDGFRB0.75811478
84CCNB10.72976491
85RPS6KA40.72474241
86CSNK1E0.72225053
87PDGFRA0.72074184
88MAPK130.71138287
89CSNK1G10.69146981
90PRKDC0.68401434
91MAPK140.66621612
92YES10.66563794
93MAP2K20.66346999
94GSK3B0.63798222
95CSNK1G20.63230079
96RPS6KB10.62290690
97MAP3K80.61827250
98DMPK0.60818060
99OXSR10.60764518
100EPHA40.60298715
101SGK10.57281247
102RIPK10.57271268
103MAP3K20.56662134
104MAPK100.56244981
105MAP3K60.56104336
106EPHA20.55158878
107WNK10.53174028
108BCR0.51461795
109MAPK80.50415415
110STK40.48779646
111NTRK20.48474004
112CHUK0.47995176
113RPS6KB20.46808517
114WNK30.46114970
115CSNK1G30.45837510
116TGFBR10.45155475
117MAP2K40.44887050
118RPS6KA10.44829801
119STK110.44697552
120DYRK1A0.44679582
121SMG10.43762007
122AKT10.43228355
123CAMK40.42889974
124FGFR40.41877756
125MAP3K50.41699454
126MAP3K90.41413241
127CDK30.40494780
128STK240.38269056

Predicted pathways (KEGG)

RankGene SetZ-score
1mRNA surveillance pathway_Homo sapiens_hsa030152.35253010
2RNA transport_Homo sapiens_hsa030132.27009127
3Cell cycle_Homo sapiens_hsa041102.22140283
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89338877
5Spliceosome_Homo sapiens_hsa030401.74556131
6Oocyte meiosis_Homo sapiens_hsa041141.71489695
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70348192
8Colorectal cancer_Homo sapiens_hsa052101.62825146
9Fanconi anemia pathway_Homo sapiens_hsa034601.62501246
10Endometrial cancer_Homo sapiens_hsa052131.61295105
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.55773437
12Mismatch repair_Homo sapiens_hsa034301.55575333
13MicroRNAs in cancer_Homo sapiens_hsa052061.48631493
14Hippo signaling pathway_Homo sapiens_hsa043901.45651467
15mTOR signaling pathway_Homo sapiens_hsa041501.42822267
16Basal cell carcinoma_Homo sapiens_hsa052171.41055487
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40567452
18Adherens junction_Homo sapiens_hsa045201.40218231
19DNA replication_Homo sapiens_hsa030301.37707692
20Long-term potentiation_Homo sapiens_hsa047201.35460077
21Non-homologous end-joining_Homo sapiens_hsa034501.35098430
22Basal transcription factors_Homo sapiens_hsa030221.29580255
23Wnt signaling pathway_Homo sapiens_hsa043101.28621568
24RNA degradation_Homo sapiens_hsa030181.27693954
25Homologous recombination_Homo sapiens_hsa034401.23720477
26Chronic myeloid leukemia_Homo sapiens_hsa052201.16220216
27Dorso-ventral axis formation_Homo sapiens_hsa043201.13824230
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12069890
29Axon guidance_Homo sapiens_hsa043601.11700343
30Hedgehog signaling pathway_Homo sapiens_hsa043401.09280971
31Prostate cancer_Homo sapiens_hsa052151.09047599
32Glioma_Homo sapiens_hsa052141.08626205
33Non-small cell lung cancer_Homo sapiens_hsa052231.07510636
34TGF-beta signaling pathway_Homo sapiens_hsa043501.06619179
35Systemic lupus erythematosus_Homo sapiens_hsa053221.05758314
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03839930
37Viral carcinogenesis_Homo sapiens_hsa052031.03244874
38Alcoholism_Homo sapiens_hsa050341.01087706
39HTLV-I infection_Homo sapiens_hsa051661.00864466
40Thyroid cancer_Homo sapiens_hsa052160.98665333
41ErbB signaling pathway_Homo sapiens_hsa040120.98569681
42p53 signaling pathway_Homo sapiens_hsa041150.97243032
43Small cell lung cancer_Homo sapiens_hsa052220.94986080
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92255984
45Dopaminergic synapse_Homo sapiens_hsa047280.91522392
46Amphetamine addiction_Homo sapiens_hsa050310.90958165
47Estrogen signaling pathway_Homo sapiens_hsa049150.89943301
48Renal cell carcinoma_Homo sapiens_hsa052110.88790382
49FoxO signaling pathway_Homo sapiens_hsa040680.88278614
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87394870
51Pancreatic cancer_Homo sapiens_hsa052120.87381395
52RNA polymerase_Homo sapiens_hsa030200.86675907
53Epstein-Barr virus infection_Homo sapiens_hsa051690.86669944
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.86306501
55Base excision repair_Homo sapiens_hsa034100.86141542
56Nucleotide excision repair_Homo sapiens_hsa034200.85010346
57Melanogenesis_Homo sapiens_hsa049160.84343053
58Type II diabetes mellitus_Homo sapiens_hsa049300.84015216
59AMPK signaling pathway_Homo sapiens_hsa041520.84010753
60Proteoglycans in cancer_Homo sapiens_hsa052050.81602307
61Tight junction_Homo sapiens_hsa045300.79846548
62Notch signaling pathway_Homo sapiens_hsa043300.79764844
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79291340
64Pathways in cancer_Homo sapiens_hsa052000.78862708
65T cell receptor signaling pathway_Homo sapiens_hsa046600.78357908
66Circadian rhythm_Homo sapiens_hsa047100.78270276
67Insulin signaling pathway_Homo sapiens_hsa049100.78201780
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77574100
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76824600
70Olfactory transduction_Homo sapiens_hsa047400.76538478
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76125585
72MAPK signaling pathway_Homo sapiens_hsa040100.75664669
73Long-term depression_Homo sapiens_hsa047300.73214971
74Herpes simplex infection_Homo sapiens_hsa051680.73015270
75Circadian entrainment_Homo sapiens_hsa047130.71613179
76Nicotine addiction_Homo sapiens_hsa050330.70886553
77Insulin resistance_Homo sapiens_hsa049310.70828325
78Antigen processing and presentation_Homo sapiens_hsa046120.70292766
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70089192
80Inositol phosphate metabolism_Homo sapiens_hsa005620.69949155
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69689105
82Hepatitis B_Homo sapiens_hsa051610.69184575
83Prolactin signaling pathway_Homo sapiens_hsa049170.68034394
84Viral myocarditis_Homo sapiens_hsa054160.66685273
85Choline metabolism in cancer_Homo sapiens_hsa052310.63923767
86Glutamatergic synapse_Homo sapiens_hsa047240.62837527
87Taste transduction_Homo sapiens_hsa047420.62662445
88Lysine degradation_Homo sapiens_hsa003100.62521977
89Melanoma_Homo sapiens_hsa052180.62517102
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62203133
91VEGF signaling pathway_Homo sapiens_hsa043700.60844004
92Selenocompound metabolism_Homo sapiens_hsa004500.60384176
93One carbon pool by folate_Homo sapiens_hsa006700.60355799
94Rap1 signaling pathway_Homo sapiens_hsa040150.60328756
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.58114438
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57991512
97Oxytocin signaling pathway_Homo sapiens_hsa049210.57689642
98GnRH signaling pathway_Homo sapiens_hsa049120.57007922
99Focal adhesion_Homo sapiens_hsa045100.56898592
100B cell receptor signaling pathway_Homo sapiens_hsa046620.56791680
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56474829
102Acute myeloid leukemia_Homo sapiens_hsa052210.56198423
103Cholinergic synapse_Homo sapiens_hsa047250.55283674
104Gap junction_Homo sapiens_hsa045400.54593846
105Fatty acid biosynthesis_Homo sapiens_hsa000610.54002520
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.53667860
107Steroid biosynthesis_Homo sapiens_hsa001000.52759694
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52675038
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51853005
110Ovarian steroidogenesis_Homo sapiens_hsa049130.51528476
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.50628388
112Hepatitis C_Homo sapiens_hsa051600.50334926
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49208739
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43250952
115cAMP signaling pathway_Homo sapiens_hsa040240.41780627
116Ras signaling pathway_Homo sapiens_hsa040140.41567253
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41289581
118HIF-1 signaling pathway_Homo sapiens_hsa040660.39967092

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