TRIM34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of muscle hypertrophy (GO:0014741)9.62704147
2skeletal muscle tissue regeneration (GO:0043403)8.95610015
3negative regulation of skeletal muscle tissue development (GO:0048642)8.32273765
4muscle filament sliding (GO:0030049)8.17407856
5actin-myosin filament sliding (GO:0033275)8.17407856
6regulation of skeletal muscle contraction (GO:0014819)7.67247877
7response to muscle activity (GO:0014850)7.11637010
8actin-mediated cell contraction (GO:0070252)6.67053887
9cellular response to dexamethasone stimulus (GO:0071549)5.96684304
10response to activity (GO:0014823)5.59752071
11response to dexamethasone (GO:0071548)5.51130631
12actin filament-based movement (GO:0030048)5.01576855
13striated muscle adaptation (GO:0014888)4.94664696
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52828644
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.44314276
16regulation of muscle hypertrophy (GO:0014743)4.36779093
17negative regulation of cell killing (GO:0031342)4.31441829
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.31441829
19muscle adaptation (GO:0043500)4.23325133
20positive regulation of gamma-delta T cell activation (GO:0046645)4.22357663
21negative regulation of fatty acid biosynthetic process (GO:0045717)4.17357118
22dosage compensation (GO:0007549)3.78373469
23tissue regeneration (GO:0042246)3.76371156
24skeletal muscle contraction (GO:0003009)3.76176596
25positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.56645119
26regulation of B cell receptor signaling pathway (GO:0050855)3.39033323
27response to testosterone (GO:0033574)3.36096274
28protein K6-linked ubiquitination (GO:0085020)3.27901075
29cellular response to glucocorticoid stimulus (GO:0071385)3.27225479
30positive regulation of B cell differentiation (GO:0045579)3.25517393
31regulation of gamma-delta T cell activation (GO:0046643)3.25065153
32regulation of relaxation of muscle (GO:1901077)3.19958934
33germinal center formation (GO:0002467)3.15840485
34antigen processing and presentation of endogenous antigen (GO:0019883)3.12779313
35cellular response to type I interferon (GO:0071357)3.12074084
36type I interferon signaling pathway (GO:0060337)3.12074084
37cytidine deamination (GO:0009972)3.09677411
38cytidine metabolic process (GO:0046087)3.09677411
39cytidine catabolic process (GO:0006216)3.09677411
40cellular response to corticosteroid stimulus (GO:0071384)3.08460812
41negative regulation of histone acetylation (GO:0035067)3.07144011
42response to type I interferon (GO:0034340)3.06102681
43interferon-gamma-mediated signaling pathway (GO:0060333)3.05310456
44neutrophil activation involved in immune response (GO:0002283)3.04709015
45negative regulation of T cell mediated immunity (GO:0002710)3.01639605
46response to electrical stimulus (GO:0051602)2.99570466
47cellular response to ketone (GO:1901655)2.99130453
48myotube cell development (GO:0014904)2.99050459
49muscle organ development (GO:0007517)2.98700479
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97646651
51heparin metabolic process (GO:0030202)2.96274117
52heparin biosynthetic process (GO:0030210)2.96274117
53negative regulation of striated muscle tissue development (GO:0045843)2.93004055
54immunoglobulin mediated immune response (GO:0016064)2.91669144
55muscle structure development (GO:0061061)2.90424031
56regulation of germinal center formation (GO:0002634)2.89677136
57macrophage activation involved in immune response (GO:0002281)2.85731649
58regulation of gamma-delta T cell differentiation (GO:0045586)2.83008436
59B cell receptor signaling pathway (GO:0050853)2.82767202
60negative regulation of muscle tissue development (GO:1901862)2.81031531
61negative regulation of muscle organ development (GO:0048635)2.79354933
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78092292
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77899894
64positive regulation by symbiont of host defense response (GO:0052509)2.76850275
65modulation by symbiont of host defense response (GO:0052031)2.76850275
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76850275
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76850275
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.76850275
69modulation by symbiont of host immune response (GO:0052553)2.76850275
70negative regulation of peptidyl-lysine acetylation (GO:2000757)2.74554503
71cellular extravasation (GO:0045123)2.74470077
72regulation of T cell mediated cytotoxicity (GO:0001914)2.69904250
73viral genome replication (GO:0019079)2.69505448
74positive regulation of histone H3-K4 methylation (GO:0051571)2.69453032
75negative regulation of organelle assembly (GO:1902116)2.68797454
76regulation of interferon-beta biosynthetic process (GO:0045357)2.63068476
77pyrimidine ribonucleoside catabolic process (GO:0046133)2.60910044
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59735732
79muscle system process (GO:0003012)2.59355167
80regulation of DNA methylation (GO:0044030)2.56927901
81regulation of regulatory T cell differentiation (GO:0045589)2.50251060
82negative regulation of interleukin-12 production (GO:0032695)2.50238930
83negative regulation of fatty acid metabolic process (GO:0045922)2.46554652
84cellular response to thyroid hormone stimulus (GO:0097067)2.46406062
85response to interferon-beta (GO:0035456)2.43903310
86neutrophil activation (GO:0042119)2.43828853
87regulation of B cell differentiation (GO:0045577)2.41996954
88muscle contraction (GO:0006936)2.41232796
89monocyte differentiation (GO:0030224)2.39760986
90skeletal muscle fiber development (GO:0048741)2.37761466
91sarcoplasmic reticulum calcium ion transport (GO:0070296)2.36783850
92T cell migration (GO:0072678)2.36090325
93regulation of T cell tolerance induction (GO:0002664)2.35827043
94cellular response to interferon-gamma (GO:0071346)2.35073327
95DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.34483026
96regulation of myeloid cell apoptotic process (GO:0033032)2.33847270
97response to gravity (GO:0009629)12.6267843
98skeletal muscle adaptation (GO:0043501)11.9705044
99striated muscle atrophy (GO:0014891)11.7186144
100muscle atrophy (GO:0014889)10.3053461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.97986433
2VDR_22108803_ChIP-Seq_LS180_Human6.05392770
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.96096195
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.35536732
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.89288512
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61819578
7* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38057162
8* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16599559
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05801866
10TAF15_26573619_Chip-Seq_HEK293_Human2.90201682
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.86684243
12GATA1_22025678_ChIP-Seq_K562_Human2.75427911
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54743168
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.48560922
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39923103
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39405183
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22102585
18VDR_24787735_ChIP-Seq_THP-1_Human2.19776210
19* SPI1_23127762_ChIP-Seq_K562_Human2.19011997
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17758372
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15466760
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14971823
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14121861
24RUNX_20019798_ChIP-Seq_JUKART_Human2.08721749
25MYB_26560356_Chip-Seq_TH2_Human2.02191444
26AR_21572438_ChIP-Seq_LNCaP_Human1.96879551
27VDR_24763502_ChIP-Seq_THP-1_Human1.83876256
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81536772
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75489614
30* SPI1_23547873_ChIP-Seq_NB4_Human1.74994183
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70769390
32MYB_26560356_Chip-Seq_TH1_Human1.63995408
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61758168
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.59955412
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55230560
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.53319634
37* MAF_26560356_Chip-Seq_TH1_Human1.44053721
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43431415
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.39949715
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.36813001
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34043723
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33181748
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32038079
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31449856
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25077035
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23439300
47SCL_19346495_ChIP-Seq_HPC-7_Human1.22709176
48RXR_22108803_ChIP-Seq_LS180_Human1.21017799
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19579764
50FUS_26573619_Chip-Seq_HEK293_Human1.18666735
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16609088
52ER_23166858_ChIP-Seq_MCF-7_Human1.15899054
53GATA3_27048872_Chip-Seq_THYMUS_Human1.13222558
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10533642
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08993977
56PU_27001747_Chip-Seq_BMDM_Mouse1.08396013
57UTX_26944678_Chip-Seq_JUKART_Human1.06869977
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06795739
59GATA3_26560356_Chip-Seq_TH2_Human1.05616651
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04882451
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03490647
62BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99868414
63GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99679989
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98788499
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95600153
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94720921
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94478618
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93055121
69RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92690896
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90394544
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90324733
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89704442
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88985272
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88556537
75KDM2B_26808549_Chip-Seq_REH_Human0.88308631
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87853591
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87752238
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87725868
79* CEBPB_22108803_ChIP-Seq_LS180_Human0.82380850
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82082230
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78558155
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76455081
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75499802
84CDX2_22108803_ChIP-Seq_LS180_Human0.74461645
85TCF7_22412390_ChIP-Seq_EML_Mouse0.73756955
86CJUN_26792858_Chip-Seq_BT549_Human0.73289649
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73229760
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72508689
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71922876
90GATA3_26560356_Chip-Seq_TH1_Human0.71828229
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71248323
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70887018
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.69785718
94ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69729959
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.69405494
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.68121717
97TFEB_21752829_ChIP-Seq_HELA_Human0.67018676
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.66926037
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66703784
100* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.66454680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000747_muscle_weakness4.72057239
2MP0004145_abnormal_muscle_electrophysio3.84366596
3MP0003705_abnormal_hypodermis_morpholog3.67353213
4MP0004036_abnormal_muscle_relaxation3.55167578
5MP0002089_abnormal_postnatal_growth/wei3.51487693
6MP0001835_abnormal_antigen_presentation3.20826697
7MP0000749_muscle_degeneration3.19205155
8MP0002269_muscular_atrophy3.18340014
9MP0005083_abnormal_biliary_tract3.08233988
10MP0003724_increased_susceptibility_to2.94292868
11MP0000759_abnormal_skeletal_muscle2.79789721
12MP0002108_abnormal_muscle_morphology2.25132420
13MP0003191_abnormal_cellular_cholesterol2.24856962
14MP0004087_abnormal_muscle_fiber2.18105546
15MP0003303_peritoneal_inflammation2.15958319
16MP0002106_abnormal_muscle_physiology2.10648693
17MP0005387_immune_system_phenotype2.06143611
18MP0001790_abnormal_immune_system2.06143611
19MP0009785_altered_susceptibility_to2.05753065
20MP0005671_abnormal_response_to2.05096914
21MP0002723_abnormal_immune_serum1.99256550
22MP0005620_abnormal_muscle_contractility1.97665655
23MP0003959_abnormal_lean_body1.95213143
24MP0005000_abnormal_immune_tolerance1.92572283
25MP0000685_abnormal_immune_system1.92454533
26MP0002419_abnormal_innate_immunity1.91337817
27MP0001800_abnormal_humoral_immune1.90046624
28MP0003436_decreased_susceptibility_to1.81816493
29MP0002452_abnormal_antigen_presenting1.76464945
30MP0005025_abnormal_response_to1.67851344
31MP0000372_irregular_coat_pigmentation1.67761520
32MP0002420_abnormal_adaptive_immunity1.66969522
33MP0002148_abnormal_hypersensitivity_rea1.65192001
34MP0004947_skin_inflammation1.64388801
35MP0001819_abnormal_immune_cell1.64088883
36MP0003045_fibrosis1.58965213
37MP0005369_muscle_phenotype1.58945252
38MP0003950_abnormal_plasma_membrane1.53670743
39MP0008438_abnormal_cutaneous_collagen1.46627944
40MP0000733_abnormal_muscle_development1.45473944
41MP0006082_CNS_inflammation1.40252102
42MP0003763_abnormal_thymus_physiology1.39195481
43MP0000750_abnormal_muscle_regeneration1.35910606
44MP0000751_myopathy1.32090428
45MP0008469_abnormal_protein_level1.31961655
46MP0002332_abnormal_exercise_endurance1.28322028
47MP0005166_decreased_susceptibility_to1.25751575
48MP0001243_abnormal_dermal_layer1.25576082
49MP0003806_abnormal_nucleotide_metabolis1.25441038
50MP0002896_abnormal_bone_mineralization1.22851833
51MP0005464_abnormal_platelet_physiology1.22493538
52MP0002398_abnormal_bone_marrow1.21239803
53MP0001533_abnormal_skeleton_physiology1.18359729
54MP0000716_abnormal_immune_system1.16374285
55MP0003828_pulmonary_edema1.10355793
56MP0006054_spinal_hemorrhage1.08975641
57MP0004484_altered_response_of1.05767857
58MP0010155_abnormal_intestine_physiology1.05295425
59MP0002166_altered_tumor_susceptibility1.04429670
60MP0010307_abnormal_tumor_latency1.03473854
61MP0001845_abnormal_inflammatory_respons1.02999388
62MP0000427_abnormal_hair_cycle1.02799738
63MP0002722_abnormal_immune_system1.02323154
64MP0002277_abnormal_respiratory_mucosa1.02122696
65MP0000569_abnormal_digit_pigmentation0.99885108
66MP0000689_abnormal_spleen_morphology0.99647518
67MP0005167_abnormal_blood-brain_barrier0.99277574
68MP0003795_abnormal_bone_structure0.98191367
69MP0009764_decreased_sensitivity_to0.96550007
70MP0004130_abnormal_muscle_cell0.95629761
71MP0003300_gastrointestinal_ulcer0.94843983
72MP0002405_respiratory_system_inflammati0.90513968
73MP0000465_gastrointestinal_hemorrhage0.89129126
74MP0003075_altered_response_to0.87703822
75MP0002095_abnormal_skin_pigmentation0.87663741
76MP0005334_abnormal_fat_pad0.86977429
77MP0003646_muscle_fatigue0.86925160
78MP0001542_abnormal_bone_strength0.86539320
79MP0002429_abnormal_blood_cell0.83305381
80MP0002396_abnormal_hematopoietic_system0.83033432
81MP0002138_abnormal_hepatobiliary_system0.82907252
82MP0000343_altered_response_to0.81048169
83MP0003786_premature_aging0.81019928
84MP0000703_abnormal_thymus_morphology0.80227513
85MP0009333_abnormal_splenocyte_physiolog0.78142997
86MP0002971_abnormal_brown_adipose0.77441508
87MP0003091_abnormal_cell_migration0.75200283
88MP0004510_myositis0.74173762
89MP0003252_abnormal_bile_duct0.72480982
90MP0002132_abnormal_respiratory_system0.72024225
91MP0005275_abnormal_skin_tensile0.68730558
92MP0004084_abnormal_cardiac_muscle0.66809644
93MP0002998_abnormal_bone_remodeling0.64586301
94MP0002006_tumorigenesis0.61855342
95MP0001851_eye_inflammation0.61156262
96MP0003566_abnormal_cell_adhesion0.58941031
97MP0005390_skeleton_phenotype0.58583797
98MP0003866_abnormal_defecation0.57726929
99MP0005397_hematopoietic_system_phenotyp0.57576114
100MP0001545_abnormal_hematopoietic_system0.57576114

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)9.41508807
2Exercise-induced myalgia (HP:0003738)7.39387265
3Distal arthrogryposis (HP:0005684)7.12915719
4Mask-like facies (HP:0000298)7.02106307
5Nemaline bodies (HP:0003798)6.93442139
6Round ear (HP:0100830)6.46435785
7Ulnar deviation of the wrist (HP:0003049)5.80037983
8Muscle fiber inclusion bodies (HP:0100299)5.50081142
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.44413842
10Absent phalangeal crease (HP:0006109)5.43372568
11Hyperkalemia (HP:0002153)5.20385029
12Periorbital edema (HP:0100539)4.87754941
13Calcaneovalgus deformity (HP:0001848)4.87290702
14Facial edema (HP:0000282)4.71766472
15Abnormal finger flexion creases (HP:0006143)4.66713009
16Type 1 muscle fiber predominance (HP:0003803)4.42959274
17Deformed tarsal bones (HP:0008119)4.36609690
18Myopathic facies (HP:0002058)3.78601273
19Myoglobinuria (HP:0002913)3.75466989
20Increased connective tissue (HP:0009025)3.60325320
21Exercise-induced muscle cramps (HP:0003710)3.40488903
22Difficulty running (HP:0009046)3.32415308
23Abnormality of the peritoneum (HP:0002585)3.28252137
24Recurrent bacterial skin infections (HP:0005406)3.23275509
25Rhabdomyolysis (HP:0003201)3.06597301
26Recurrent abscess formation (HP:0002722)3.01427684
27Abnormality of potassium homeostasis (HP:0011042)2.95017754
28Reduced subcutaneous adipose tissue (HP:0003758)2.84537069
29Elevated erythrocyte sedimentation rate (HP:0003565)2.82926198
30Neoplasm of the heart (HP:0100544)2.81831527
31Nonprogressive disorder (HP:0003680)2.62723078
32Myositis (HP:0100614)2.59146444
33Metatarsus adductus (HP:0001840)2.54007545
34Eczematoid dermatitis (HP:0000976)2.51946511
35Agammaglobulinemia (HP:0004432)2.44433634
36Abnormality of the calcaneus (HP:0008364)2.43197771
37Increased variability in muscle fiber diameter (HP:0003557)2.38905709
38Myotonia (HP:0002486)2.35656951
39Oligomenorrhea (HP:0000876)2.31158257
40Cellulitis (HP:0100658)2.28963541
41Orchitis (HP:0100796)2.27330193
42Muscle stiffness (HP:0003552)2.26104053
43Abnormality of macrophages (HP:0004311)2.26065814
44Mediastinal lymphadenopathy (HP:0100721)2.24088518
45Optic neuritis (HP:0100653)2.23808138
46Retrobulbar optic neuritis (HP:0100654)2.23808138
47Toxemia of pregnancy (HP:0100603)2.23272871
48Abnormality of skeletal muscle fiber size (HP:0012084)2.22972747
49Meningitis (HP:0001287)2.20649939
50Spontaneous hematomas (HP:0007420)2.16122462
51Malignant hyperthermia (HP:0002047)2.12529497
52Stomatitis (HP:0010280)2.11373253
53Chest pain (HP:0100749)2.06291544
54Decreased circulating renin level (HP:0003351)2.05864522
55Microglossia (HP:0000171)2.05467572
56Recurrent fungal infections (HP:0002841)2.03520472
57Recurrent skin infections (HP:0001581)2.00652899
58Hyperphosphatemia (HP:0002905)2.00549087
59T lymphocytopenia (HP:0005403)1.98939420
60Abnormality of chloride homeostasis (HP:0011422)1.93239276
61Down-sloping shoulders (HP:0200021)1.93218654
62Abnormality of the prostate (HP:0008775)1.90840145
63Gastrointestinal infarctions (HP:0005244)1.90293674
64Paralysis (HP:0003470)1.89910097
65Vasculitis (HP:0002633)1.89278587
66Abnormality of T cell number (HP:0011839)1.87636314
67Autoimmune hemolytic anemia (HP:0001890)1.87541840
68Abnormal delayed hypersensitivity skin test (HP:0002963)1.85812615
69Recurrent viral infections (HP:0004429)1.84948166
70Recurrent gram-negative bacterial infections (HP:0005420)1.81486022
71Pulmonary embolism (HP:0002204)1.80558470
72Bell-shaped thorax (HP:0001591)1.77828741
73IgM deficiency (HP:0002850)1.77662943
74Menstrual irregularities (HP:0000858)1.73645406
75Pulmonary infiltrates (HP:0002113)1.72745613
76Fatigue (HP:0012378)1.72694225
77Lip pit (HP:0100267)1.72620795
78Recurrent bronchitis (HP:0002837)1.71838828
79Chronic mucocutaneous candidiasis (HP:0002728)1.70583120
80Recurrent cutaneous fungal infections (HP:0011370)1.70583120
81Abnormality of the columella (HP:0009929)1.69929249
82Panhypogammaglobulinemia (HP:0003139)1.69786510
83Hypokalemia (HP:0002900)1.69676437
84Obstructive lung disease (HP:0006536)1.69633376
85Chronic obstructive pulmonary disease (HP:0006510)1.69633376
86Encephalitis (HP:0002383)1.69413134
87Peritonitis (HP:0002586)1.67008789
88Keratoconjunctivitis sicca (HP:0001097)1.58938904
89Hemoptysis (HP:0002105)1.55772337
90Facial diplegia (HP:0001349)1.53564080
91Arterial thrombosis (HP:0004420)1.53197692
92Muscle hypertrophy of the lower extremities (HP:0008968)1.53053202
93Prostate neoplasm (HP:0100787)1.51999501
94Hypoalphalipoproteinemia (HP:0003233)1.49747300
95Hematochezia (HP:0002573)1.49280380
96Chronic otitis media (HP:0000389)1.49223528
97Neck muscle weakness (HP:0000467)1.48928009
98Glucose intolerance (HP:0000833)1.48695004
993-Methylglutaconic aciduria (HP:0003535)1.47650400
100Hypoplastic ischia (HP:0003175)1.46065771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.14221761
2TESK23.96693144
3OBSCN3.49088949
4JAK33.37253668
5PHKG13.00560863
6PHKG23.00560863
7RIPK42.30443028
8MAP4K12.24349624
9CAMKK22.13752058
10IRAK12.12192854
11PIK3CG2.07096476
12TEC1.88105090
13WNK41.82420359
14TNK21.82035237
15MAP2K31.80110972
16WNK11.77921596
17BLK1.69942826
18CAMK1D1.67242125
19FES1.53168761
20TXK1.50533537
21MST41.48934743
22CSK1.48530122
23TRPM71.45375582
24SYK1.40498765
25IKBKE1.38703026
26MAP3K141.36325699
27TYRO31.36035196
28TAOK31.32449549
29LIMK11.27771546
30GRK71.27256251
31TBK11.24934595
32CSF1R1.24396448
33TYK21.22808644
34MAPK131.20071387
35PIK3CA1.19008818
36MARK31.16748479
37BTK1.13210020
38CCNB11.08104190
39TESK11.07589039
40CDK41.06867653
41MAP3K111.02651749
42MAPK71.01962171
43MAP3K121.01118842
44DDR21.00616509
45MAP3K10.99419221
46FGFR30.98908714
47KIT0.97718204
48MAP3K30.95837626
49CAMK1G0.95724969
50DYRK1B0.95281974
51IRAK40.95262899
52TLK10.94408379
53ITK0.94286287
54FER0.90466661
55ERN10.84601819
56LYN0.83778464
57NUAK10.81157127
58CAMK2G0.78688673
59HCK0.76721313
60FRK0.76490519
61MAPK120.75057956
62EIF2AK30.74371486
63FGR0.71475285
64IKBKB0.69661675
65BMPR20.68776492
66LCK0.67955403
67TAOK10.67475474
68TGFBR20.67053168
69ZAP700.61883046
70PRKD20.60385694
71STK100.58014906
72OXSR10.56082615
73JAK10.55425925
74PIM10.55291549
75MOS0.54777204
76MAPKAPK30.53198368
77CHEK20.51711599
78PRKCQ0.49777036
79GRK60.49547148
80AURKA0.49389239
81PDK10.47488668
82JAK20.47443761
83NEK90.46748472
84SCYL20.46221279
85EIF2AK20.46013487
86BCKDK0.43838550
87PRKD10.42328941
88DAPK20.41594063
89SIK30.40424466
90CAMKK10.39720043
91TAOK20.38705986
92MATK0.38414368
93GRK10.38407400
94STK390.37276358
95NLK0.36523028
96PTK2B0.35611271
97NME20.35594850
98HIPK20.35471612
99ABL10.34988838
100MAPK110.32917190

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.22231337
2Allograft rejection_Homo sapiens_hsa053303.09849932
3Autoimmune thyroid disease_Homo sapiens_hsa053202.86654423
4Tight junction_Homo sapiens_hsa045302.73834095
5Regulation of autophagy_Homo sapiens_hsa041402.72056796
6Asthma_Homo sapiens_hsa053102.65206053
7Antigen processing and presentation_Homo sapiens_hsa046122.47137924
8Leishmaniasis_Homo sapiens_hsa051402.29841494
9Primary immunodeficiency_Homo sapiens_hsa053402.29327485
10Staphylococcus aureus infection_Homo sapiens_hsa051502.24275552
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.21639297
12Type I diabetes mellitus_Homo sapiens_hsa049402.20062431
13Osteoclast differentiation_Homo sapiens_hsa043802.16266884
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15615636
15Viral myocarditis_Homo sapiens_hsa054162.05968891
16B cell receptor signaling pathway_Homo sapiens_hsa046622.01256852
17Tuberculosis_Homo sapiens_hsa051521.89171584
18Measles_Homo sapiens_hsa051621.77704020
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74224404
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.72112495
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63528757
22Platelet activation_Homo sapiens_hsa046111.54024818
23Rheumatoid arthritis_Homo sapiens_hsa053231.53023157
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50645315
25Hematopoietic cell lineage_Homo sapiens_hsa046401.40881121
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39621199
27Influenza A_Homo sapiens_hsa051641.39403389
28Herpes simplex infection_Homo sapiens_hsa051681.38917599
29Oxytocin signaling pathway_Homo sapiens_hsa049211.37769764
30Toxoplasmosis_Homo sapiens_hsa051451.34744400
31T cell receptor signaling pathway_Homo sapiens_hsa046601.33103537
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22803030
33Legionellosis_Homo sapiens_hsa051341.21096045
34Malaria_Homo sapiens_hsa051441.20083629
35Nitrogen metabolism_Homo sapiens_hsa009101.19324556
36Shigellosis_Homo sapiens_hsa051311.14502555
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14309275
38Renin secretion_Homo sapiens_hsa049241.14056856
39Chemokine signaling pathway_Homo sapiens_hsa040621.12869312
40Systemic lupus erythematosus_Homo sapiens_hsa053221.06671391
41Calcium signaling pathway_Homo sapiens_hsa040201.01886378
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00676661
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.96231366
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.92307357
45Gastric acid secretion_Homo sapiens_hsa049710.91846865
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.91444818
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90244531
48Phagosome_Homo sapiens_hsa041450.88503543
49African trypanosomiasis_Homo sapiens_hsa051430.88121512
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87224433
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83864074
52Epstein-Barr virus infection_Homo sapiens_hsa051690.83314758
53TNF signaling pathway_Homo sapiens_hsa046680.82471860
54Salmonella infection_Homo sapiens_hsa051320.82265889
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74965367
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74550704
57Pertussis_Homo sapiens_hsa051330.73336199
58Endocytosis_Homo sapiens_hsa041440.67860210
59Acute myeloid leukemia_Homo sapiens_hsa052210.66878249
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66272452
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65855110
62Viral carcinogenesis_Homo sapiens_hsa052030.65599827
63Hepatitis C_Homo sapiens_hsa051600.64803824
64Amoebiasis_Homo sapiens_hsa051460.64010159
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63345178
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61517317
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.60110365
68Glucagon signaling pathway_Homo sapiens_hsa049220.55632390
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53197343
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52249029
71HIF-1 signaling pathway_Homo sapiens_hsa040660.51712923
72GnRH signaling pathway_Homo sapiens_hsa049120.50937115
73Circadian rhythm_Homo sapiens_hsa047100.48487264
74Insulin resistance_Homo sapiens_hsa049310.47642993
75HTLV-I infection_Homo sapiens_hsa051660.46625719
76Proteasome_Homo sapiens_hsa030500.46089802
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45665695
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43620996
79Salivary secretion_Homo sapiens_hsa049700.43528170
80Hepatitis B_Homo sapiens_hsa051610.42947398
81Long-term depression_Homo sapiens_hsa047300.42035744
82Circadian entrainment_Homo sapiens_hsa047130.41851291
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41114436
84Dorso-ventral axis formation_Homo sapiens_hsa043200.40481863
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40097540
86Long-term potentiation_Homo sapiens_hsa047200.39815443
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39669019
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37491157
89Pancreatic secretion_Homo sapiens_hsa049720.37007271
90Lysosome_Homo sapiens_hsa041420.36509880
91MAPK signaling pathway_Homo sapiens_hsa040100.36221398
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34033012
93Adherens junction_Homo sapiens_hsa045200.32220841
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.31073437
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30639696
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29872617
97VEGF signaling pathway_Homo sapiens_hsa043700.28432095
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.25733940
99Mineral absorption_Homo sapiens_hsa049780.25122655
100Cholinergic synapse_Homo sapiens_hsa047250.24343921

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