TRIM35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.07255772
2establishment of skin barrier (GO:0061436)6.00928289
3regulation of water loss via skin (GO:0033561)5.08822999
4keratinocyte development (GO:0003334)4.42917234
5layer formation in cerebral cortex (GO:0021819)4.34134291
6mitotic sister chromatid cohesion (GO:0007064)4.23154453
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.06662029
8synaptic vesicle maturation (GO:0016188)3.87188812
9genitalia morphogenesis (GO:0035112)3.82441139
10regulation of synapse structural plasticity (GO:0051823)3.75741754
11DNA double-strand break processing (GO:0000729)3.66224942
12nuclear pore complex assembly (GO:0051292)3.58112006
13Golgi transport vesicle coating (GO:0048200)3.49677207
14COPI coating of Golgi vesicle (GO:0048205)3.49677207
15dendritic spine morphogenesis (GO:0060997)3.46011608
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40039736
17keratinization (GO:0031424)3.38069855
18axonal fasciculation (GO:0007413)3.36974633
19negative regulation of microtubule polymerization (GO:0031115)3.35971110
20cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.35562004
21neuron recognition (GO:0008038)3.33050115
22regulation of transforming growth factor beta2 production (GO:0032909)3.32346531
23negative regulation of keratinocyte proliferation (GO:0010839)3.31717704
24protein localization to endosome (GO:0036010)3.29456892
25locomotory exploration behavior (GO:0035641)3.28933646
26dendrite morphogenesis (GO:0048813)3.28237270
27cerebellar Purkinje cell layer development (GO:0021680)3.28100353
28nuclear pore organization (GO:0006999)3.25703344
29mitotic metaphase plate congression (GO:0007080)3.20210899
30fibroblast migration (GO:0010761)3.16861246
31embryonic process involved in female pregnancy (GO:0060136)3.16324130
32regulation of synaptic vesicle exocytosis (GO:2000300)3.13633195
33mitotic nuclear envelope disassembly (GO:0007077)3.11600875
34cell migration in hindbrain (GO:0021535)3.11439414
35negative regulation of activin receptor signaling pathway (GO:0032926)3.11235253
36positive regulation of glycoprotein biosynthetic process (GO:0010560)3.11169127
37histone mRNA catabolic process (GO:0071044)3.11122680
38acrosome assembly (GO:0001675)3.11043791
39establishment of nucleus localization (GO:0040023)3.09833485
40regulation of keratinocyte proliferation (GO:0010837)3.09295751
41linoleic acid metabolic process (GO:0043651)3.08955544
42metaphase plate congression (GO:0051310)3.05606779
43synaptic vesicle exocytosis (GO:0016079)3.02624745
44activation of protein kinase A activity (GO:0034199)3.00838403
45regulation of cardioblast differentiation (GO:0051890)2.97678572
46plasma membrane repair (GO:0001778)2.97609235
47membrane disassembly (GO:0030397)2.97575789
48nuclear envelope disassembly (GO:0051081)2.97575789
49multicellular organismal water homeostasis (GO:0050891)2.96837109
50hemidesmosome assembly (GO:0031581)2.96462970
51establishment of chromosome localization (GO:0051303)2.91120500
52positive regulation of glycoprotein metabolic process (GO:1903020)2.87357941
53urea metabolic process (GO:0019627)2.86522375
54N-terminal protein amino acid acetylation (GO:0006474)2.85217304
55cell communication by electrical coupling (GO:0010644)2.81834835
56innervation (GO:0060384)2.81790695
57neuron cell-cell adhesion (GO:0007158)2.80317639
58COPII vesicle coating (GO:0048208)2.80011385
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78970013
60pyrimidine nucleobase catabolic process (GO:0006208)2.77362845
61L-serine transport (GO:0015825)2.76195963
62vocalization behavior (GO:0071625)2.75671739
63negative regulation of DNA-dependent DNA replication (GO:2000104)2.75539932
64nuclear envelope organization (GO:0006998)2.75397920
65exploration behavior (GO:0035640)2.73671373
66response to lipoprotein particle (GO:0055094)2.72555926
67dendritic spine organization (GO:0097061)2.72126031
68organelle transport along microtubule (GO:0072384)2.71345047
69synaptic vesicle docking involved in exocytosis (GO:0016081)2.71317768
70axon extension (GO:0048675)2.68666033
71ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.67881398
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.66881085
73regulation of transforming growth factor beta1 production (GO:0032908)2.65134853
74microtubule nucleation (GO:0007020)2.64471590
75regulation of plasminogen activation (GO:0010755)2.63341956
76growth hormone secretion (GO:0030252)2.63061618
77positive regulation of dendrite morphogenesis (GO:0050775)2.62309755
78spindle checkpoint (GO:0031577)2.61456913
79regulation of protein glycosylation (GO:0060049)2.61448490
80regulation of glutamate receptor signaling pathway (GO:1900449)2.61190030
81alpha-linolenic acid metabolic process (GO:0036109)2.61118033
82urea cycle (GO:0000050)2.60961575
83regulation of synaptic vesicle transport (GO:1902803)2.60644619
84protein localization to cell surface (GO:0034394)2.59845914
85rRNA methylation (GO:0031167)2.59707260
86auditory behavior (GO:0031223)2.59157868
87pore complex assembly (GO:0046931)2.57702272
88water homeostasis (GO:0030104)2.56978917
89negative regulation of execution phase of apoptosis (GO:1900118)2.56548167
90central nervous system projection neuron axonogenesis (GO:0021952)2.56011949
91regulation of neuronal synaptic plasticity (GO:0048168)2.55207523
92regulation of fibrinolysis (GO:0051917)2.55069116
93response to follicle-stimulating hormone (GO:0032354)2.54939977
94gonadal mesoderm development (GO:0007506)2.54227291
95negative regulation of catenin import into nucleus (GO:0035414)2.54027047
96protein localization to synapse (GO:0035418)2.53216979
97positive regulation of axon extension (GO:0045773)2.51249066
98S-adenosylmethionine metabolic process (GO:0046500)2.50520278
99neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.50390503
100positive regulation of synapse maturation (GO:0090129)2.49201054
101ether lipid metabolic process (GO:0046485)2.48772555
102regulation of Rac protein signal transduction (GO:0035020)2.48711779
103establishment of mitochondrion localization (GO:0051654)2.48428583
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47530690
105glycine transport (GO:0015816)2.47196716
106vesicle transport along microtubule (GO:0047496)2.46857200
107glutamate secretion (GO:0014047)2.45992635
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45390989
109keratinocyte differentiation (GO:0030216)2.44751588
110triglyceride catabolic process (GO:0019433)2.44454394
111polarized epithelial cell differentiation (GO:0030859)2.43671336
112positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.42786166
113nerve growth factor signaling pathway (GO:0038180)2.42455661
114mitochondrial DNA metabolic process (GO:0032042)2.42165977
115mitotic spindle checkpoint (GO:0071174)2.41749414
116keratinocyte proliferation (GO:0043616)2.41196575
117mitochondrial DNA replication (GO:0006264)2.40952082
118neuron projection extension (GO:1990138)2.40671575
119negative regulation of potassium ion transmembrane transport (GO:1901380)2.40326014
120nitrogen cycle metabolic process (GO:0071941)2.40072056
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39942107
122regulation of long-term neuronal synaptic plasticity (GO:0048169)2.38672069
123cerebellum development (GO:0021549)2.38098337
124Rap protein signal transduction (GO:0032486)2.37873972
125membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.37700725
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.37098099
127positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.36622585
128clathrin coat assembly (GO:0048268)2.36567853
129response to pheromone (GO:0019236)2.35717750
130signal peptide processing (GO:0006465)2.35397282
131response to X-ray (GO:0010165)2.34463244
132regulation of dendritic spine morphogenesis (GO:0061001)2.34369077
133histone H2A acetylation (GO:0043968)2.34362672
134triglyceride homeostasis (GO:0070328)2.34320949
135acylglycerol homeostasis (GO:0055090)2.34320949
136regulation of establishment of cell polarity (GO:2000114)2.33704180
137positive regulation of synaptic transmission, GABAergic (GO:0032230)2.33592408
138mechanosensory behavior (GO:0007638)2.32745036
139positive regulation of vesicle fusion (GO:0031340)2.32561618
140neuronal ion channel clustering (GO:0045161)2.32556699
141detection of calcium ion (GO:0005513)2.32359714
142mating behavior (GO:0007617)2.32268692
143axon cargo transport (GO:0008088)2.32152219
144non-recombinational repair (GO:0000726)2.30522351
145double-strand break repair via nonhomologous end joining (GO:0006303)2.30522351
146establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.30521792
147mitochondrion transport along microtubule (GO:0047497)2.30521792
148regulation of axon extension (GO:0030516)2.29998469
149positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.29917468
150vesicle coating (GO:0006901)2.29896016
151glial cell proliferation (GO:0014009)2.29840156
152female gonad development (GO:0008585)2.29168244
153neuromuscular process controlling balance (GO:0050885)2.29083523
154fatty acid elongation (GO:0030497)2.28543365
155regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.28476965
156cholesterol biosynthetic process (GO:0006695)2.27834524
157positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.27709339
158synapse organization (GO:0050808)2.26862198
159fibrinolysis (GO:0042730)2.26528460
160DNA replication-dependent nucleosome assembly (GO:0006335)2.26370905
161DNA replication-dependent nucleosome organization (GO:0034723)2.26370905
162long-chain fatty acid biosynthetic process (GO:0042759)2.26186177
163lactate metabolic process (GO:0006089)2.26134258
164cellular response to glucagon stimulus (GO:0071377)2.25823479
165regulation of vesicle fusion (GO:0031338)2.24735300
166negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.24630893
167negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.24630893
168negative regulation of mitotic sister chromatid segregation (GO:0033048)2.24630893
169negative regulation of mitotic sister chromatid separation (GO:2000816)2.24630893
170negative regulation of sister chromatid segregation (GO:0033046)2.24630893
171regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.23408169
172regulation of mitotic metaphase/anaphase transition (GO:0030071)2.23408169
173fatty-acyl-CoA metabolic process (GO:0035337)2.23044005
174protein complex localization (GO:0031503)2.23040264
175exogenous drug catabolic process (GO:0042738)2.23035049
176nucleotide-sugar biosynthetic process (GO:0009226)2.22766086
177negative regulation of cell size (GO:0045792)2.22531902
178replication fork processing (GO:0031297)2.22430863
179regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.21619142
180regulation of dendrite morphogenesis (GO:0048814)2.21345213
181negative regulation of chromosome segregation (GO:0051985)2.21290376
182regulation of spindle organization (GO:0090224)2.20134127
183hippocampus development (GO:0021766)2.20083787
184nodal signaling pathway (GO:0038092)2.19995560
185regulation of cholesterol homeostasis (GO:2000188)2.19957386
186mitotic spindle assembly checkpoint (GO:0007094)2.19907753
187negative regulation of axonogenesis (GO:0050771)2.19870947
188protein targeting to plasma membrane (GO:0072661)2.18153761
189neurotransmitter secretion (GO:0007269)2.17947094
190positive regulation of axonogenesis (GO:0050772)2.17931224
191regulation of membrane repolarization (GO:0060306)2.17472366
192stress fiber assembly (GO:0043149)2.16950829
193dopamine receptor signaling pathway (GO:0007212)2.16636573
194response to auditory stimulus (GO:0010996)2.16216231
195positive regulation of potassium ion transport (GO:0043268)2.14552931
196semaphorin-plexin signaling pathway (GO:0071526)2.14375966
197membrane repolarization (GO:0086009)2.14066223
198regulation of potassium ion transmembrane transport (GO:1901379)2.13877043
199positive regulation of dendritic spine morphogenesis (GO:0061003)2.13748154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46423690
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.81184385
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.67086917
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.62982157
5E2F7_22180533_ChIP-Seq_HELA_Human3.06847047
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.88293758
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69227894
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66118616
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56808422
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.54733666
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54417945
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54417945
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53310873
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44815317
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44449560
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44076475
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40246024
18AR_21909140_ChIP-Seq_LNCAP_Human2.35651759
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27546323
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25199166
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.25135346
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24152776
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.23793963
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23329287
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22873334
26DROSHA_22980978_ChIP-Seq_HELA_Human2.22835005
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.21310032
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.19963016
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18572938
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18402632
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.18072674
32GBX2_23144817_ChIP-Seq_PC3_Human2.16810933
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16709402
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14422142
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08729494
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.08091665
37* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05648186
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01164876
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.98276061
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92406336
41REST_21632747_ChIP-Seq_MESCs_Mouse1.91263828
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90286008
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89569631
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88326875
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85826840
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84789505
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81903673
48ZNF274_21170338_ChIP-Seq_K562_Hela1.75106488
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.72874846
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69114593
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.68606368
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.66465250
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65345968
54* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.62900126
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.62662788
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62089263
57KDM2B_26808549_Chip-Seq_K562_Human1.61582655
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59134357
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59017653
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58713354
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57262186
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55632999
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53174855
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52851258
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49963339
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48065137
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.47336221
68BRD4_25478319_ChIP-Seq_HGPS_Human1.47132141
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.45150784
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.43814956
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43690917
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43449338
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43353722
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43122255
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.42528131
76IGF1R_20145208_ChIP-Seq_DFB_Human1.41616643
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39488099
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38605500
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38109413
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37984345
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37984345
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36166565
83* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36014171
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.35698738
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35403239
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.35356928
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34695748
88* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34375285
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32982588
90AR_21572438_ChIP-Seq_LNCaP_Human1.32308079
91P300_19829295_ChIP-Seq_ESCs_Human1.31871815
92TP63_23658742_ChIP-Seq_EP156T_Human1.31827964
93BCAT_22108803_ChIP-Seq_LS180_Human1.31118960
94EWS_26573619_Chip-Seq_HEK293_Human1.29897601
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28563872
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28109255
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26588565
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26037877
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.25755449
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24266728
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23999950
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22955193
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21812689
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20980629
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20980629
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20471191
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.18065731
108* AR_19668381_ChIP-Seq_PC3_Human1.17338103
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17247049
110KDM2B_26808549_Chip-Seq_DND41_Human1.17016550
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15168900
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14310740
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12711428
114LXR_22158963_ChIP-Seq_LIVER_Mouse1.12654914
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.12505648
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12358803
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12246637
118TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10799409
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.10126054
120CHD1_26751641_Chip-Seq_LNCaP_Human1.09413534
121ELK1_19687146_ChIP-ChIP_HELA_Human1.08709909
122TP53_20018659_ChIP-ChIP_R1E_Mouse1.08452362
123TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08080610
124CDX2_22108803_ChIP-Seq_LS180_Human1.06859286
125TFEB_21752829_ChIP-Seq_HELA_Human1.06242401
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.05838140
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04896259
128HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03211397
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01895718
130CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01404098
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00940395
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00877268
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00154722
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.00000788
135TP53_18474530_ChIP-ChIP_U2OS_Human0.99177630
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.99175278
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98897881
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98837429
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98716994
140SMAD4_21799915_ChIP-Seq_A2780_Human0.97593807
141VDR_22108803_ChIP-Seq_LS180_Human0.97448503
142* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97026403
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.95822375
144TAF15_26573619_Chip-Seq_HEK293_Human0.95587518
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94861191
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.94854779
147PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94808108
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94721558
149NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94112922
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93921507
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93654451
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93062729
153EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92667375
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.91507196
155FUS_26573619_Chip-Seq_HEK293_Human0.90561556
156TET1_21490601_ChIP-Seq_MESCs_Mouse0.90381462
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.90221108
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89304917
159TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88747037
160STAT3_23295773_ChIP-Seq_U87_Human0.88648124
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88180059
162E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87999805
163CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87842368
164SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87729620
165FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87140520
166GATA6_25053715_ChIP-Seq_YYC3_Human0.87073866
167* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87036471
168GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86976919
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.86782569
170SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86761622
171NFE2_27457419_Chip-Seq_LIVER_Mouse0.86657168
172TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86583993
173TP53_23651856_ChIP-Seq_MEFs_Mouse0.86046006
174CJUN_26792858_Chip-Seq_BT549_Human0.86012099
175CLOCK_20551151_ChIP-Seq_293T_Human0.85564357
176RNF2_27304074_Chip-Seq_NSC_Mouse0.84388910
177RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84187758
178MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83984782
179FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83892927
180TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83833399
181AHR_22903824_ChIP-Seq_MCF-7_Human0.82961918
182CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81642077
183TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81316696
184TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80714491
185LXR_22292898_ChIP-Seq_THP-1_Human0.79392323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.20700568
2MP0002796_impaired_skin_barrier4.51799663
3MP0004859_abnormal_synaptic_plasticity3.81681829
4MP0006054_spinal_hemorrhage3.47161130
5MP0005501_abnormal_skin_physiology3.18408977
6MP0003705_abnormal_hypodermis_morpholog3.07972031
7MP0004270_analgesia2.98050725
8MP0003122_maternal_imprinting2.97454159
9MP0001661_extended_life_span2.84546746
10MP0000013_abnormal_adipose_tissue2.72801514
11MP0003195_calcinosis2.50801281
12MP0003566_abnormal_cell_adhesion2.35734934
13MP0003635_abnormal_synaptic_transmissio2.33834642
14MP0003941_abnormal_skin_development2.27222408
15MP0008057_abnormal_DNA_replication2.26920379
16MP0002909_abnormal_adrenal_gland2.22795452
17MP0000751_myopathy2.18494844
18MP0003283_abnormal_digestive_organ2.15383223
19MP0009697_abnormal_copulation2.11809266
20MP0001216_abnormal_epidermal_layer2.07670063
21MP0010094_abnormal_chromosome_stability2.07527172
22MP0003880_abnormal_central_pattern2.06890554
23MP0000778_abnormal_nervous_system2.04519115
24MP0008438_abnormal_cutaneous_collagen2.03879760
25MP0010352_gastrointestinal_tract_polyps2.03303601
26MP0005367_renal/urinary_system_phenotyp2.00205095
27MP0000516_abnormal_urinary_system2.00205095
28MP0002063_abnormal_learning/memory/cond1.96979159
29MP0009780_abnormal_chondrocyte_physiolo1.90871797
30MP0000569_abnormal_digit_pigmentation1.89228605
31MP0003453_abnormal_keratinocyte_physiol1.86909223
32MP0005645_abnormal_hypothalamus_physiol1.83721554
33MP0005623_abnormal_meninges_morphology1.80925077
34MP0002837_dystrophic_cardiac_calcinosis1.78546961
35MP0004858_abnormal_nervous_system1.78281025
36MP0003718_maternal_effect1.77504748
37MP0002184_abnormal_innervation1.76428355
38MP0003763_abnormal_thymus_physiology1.71691753
39MP0002734_abnormal_mechanical_nocicepti1.70315998
40MP0005360_urolithiasis1.69939058
41MP0005275_abnormal_skin_tensile1.68960782
42MP0002060_abnormal_skin_morphology1.67575545
43MP0004233_abnormal_muscle_weight1.65297932
44MP0004381_abnormal_hair_follicle1.59670532
45MP0004811_abnormal_neuron_physiology1.59572492
46MP0003121_genomic_imprinting1.57501206
47MP0000003_abnormal_adipose_tissue1.56702614
48MP0003786_premature_aging1.56570463
49MP0004145_abnormal_muscle_electrophysio1.55642062
50MP0000377_abnormal_hair_follicle1.55350239
51MP0001915_intracranial_hemorrhage1.54113037
52MP0001299_abnormal_eye_distance/1.53148495
53MP0003890_abnormal_embryonic-extraembry1.51823241
54MP0002139_abnormal_hepatobiliary_system1.51315681
55MP0000955_abnormal_spinal_cord1.50749606
56MP0003111_abnormal_nucleus_morphology1.48265635
57MP0002254_reproductive_system_inflammat1.47576275
58MP0005647_abnormal_sex_gland1.46379992
59MP0002064_seizures1.46088242
60MP0005395_other_phenotype1.45484463
61MP0010771_integument_phenotype1.45314285
62MP0004957_abnormal_blastocyst_morpholog1.44054626
63MP0009745_abnormal_behavioral_response1.43875779
64MP0002572_abnormal_emotion/affect_behav1.43420389
65MP0005423_abnormal_somatic_nervous1.43089345
66MP0000647_abnormal_sebaceous_gland1.42883901
67MP0000427_abnormal_hair_cycle1.42543201
68MP0000579_abnormal_nail_morphology1.39840052
69MP0010329_abnormal_lipoprotein_level1.34765041
70MP0000537_abnormal_urethra_morphology1.34633120
71MP0006276_abnormal_autonomic_nervous1.34514433
72MP0003329_amyloid_beta_deposits1.33951101
73MP0002733_abnormal_thermal_nociception1.33363576
74MP0010386_abnormal_urinary_bladder1.31562316
75MP0003183_abnormal_peptide_metabolism1.29968602
76MP0003787_abnormal_imprinting1.28996677
77MP0010678_abnormal_skin_adnexa1.27147935
78MP0005670_abnormal_white_adipose1.24160879
79MP0003077_abnormal_cell_cycle1.23809310
80MP0005076_abnormal_cell_differentiation1.23497346
81MP0002557_abnormal_social/conspecific_i1.22783022
82MP0002234_abnormal_pharynx_morphology1.22248517
83MP0002882_abnormal_neuron_morphology1.20064983
84MP0002272_abnormal_nervous_system1.20064321
85MP0009703_decreased_birth_body1.18305955
86MP0001970_abnormal_pain_threshold1.18271956
87MP0003385_abnormal_body_wall1.17876605
88MP0002168_other_aberrant_phenotype1.17622061
89MP0003868_abnormal_feces_composition1.16173079
90MP0001730_embryonic_growth_arrest1.16163470
91MP0001348_abnormal_lacrimal_gland1.16132280
92MP0005503_abnormal_tendon_morphology1.16130000
93MP0004084_abnormal_cardiac_muscle1.12918695
94MP0005075_abnormal_melanosome_morpholog1.12613000
95MP0001191_abnormal_skin_condition1.12392871
96MP0005365_abnormal_bile_salt1.11629523
97MP0009046_muscle_twitch1.11497415
98MP0001968_abnormal_touch/_nociception1.11401453
99MP0004947_skin_inflammation1.11194287
100MP0000534_abnormal_ureter_morphology1.09941672
101MP0003634_abnormal_glial_cell1.09726863
102MP0003123_paternal_imprinting1.09103758
103MP0000631_abnormal_neuroendocrine_gland1.08348650
104MP0001486_abnormal_startle_reflex1.08124070
105MP0001851_eye_inflammation1.07924091
106MP0003693_abnormal_embryo_hatching1.07206220
107MP0001440_abnormal_grooming_behavior1.07043951
108MP0009931_abnormal_skin_appearance1.06712310
109MP0000747_muscle_weakness1.05810078
110MP0008961_abnormal_basal_metabolism1.05608393
111MP0000015_abnormal_ear_pigmentation1.05258459
112MP0002152_abnormal_brain_morphology1.05118964
113MP0010030_abnormal_orbit_morphology1.04853695
114MP0010368_abnormal_lymphatic_system1.04777134
115MP0003828_pulmonary_edema1.03118867
116MP0004272_abnormal_basement_membrane1.02780674
117MP0003942_abnormal_urinary_system1.01854835
118MP0000759_abnormal_skeletal_muscle1.01319300
119MP0004197_abnormal_fetal_growth/weight/1.01244566
120MP0010307_abnormal_tumor_latency1.00880142
121MP0004885_abnormal_endolymph1.00102374
122MP0002877_abnormal_melanocyte_morpholog0.99844144
123MP0008569_lethality_at_weaning0.99815716
124MP0004036_abnormal_muscle_relaxation0.99257285
125MP0005187_abnormal_penis_morphology0.99156541
126MP0005085_abnormal_gallbladder_physiolo0.99080563
127MP0000467_abnormal_esophagus_morphology0.97685635
128MP0000465_gastrointestinal_hemorrhage0.97218536
129MP0000733_abnormal_muscle_development0.95779807
130MP0002751_abnormal_autonomic_nervous0.95529499
131MP0003943_abnormal_hepatobiliary_system0.95448593
132MP0002896_abnormal_bone_mineralization0.95252319
133MP0005257_abnormal_intraocular_pressure0.95216908
134MP0001958_emphysema0.95201406
135MP0003861_abnormal_nervous_system0.94957878
136MP0003119_abnormal_digestive_system0.94640555
137MP0002735_abnormal_chemical_nociception0.94576738
138MP0009672_abnormal_birth_weight0.94453606
139MP0002066_abnormal_motor_capabilities/c0.94218448
140MP0002067_abnormal_sensory_capabilities0.93923210
141MP0001984_abnormal_olfaction0.93851947
142MP0006035_abnormal_mitochondrial_morpho0.93406989
143MP0002106_abnormal_muscle_physiology0.93118566
144MP0008789_abnormal_olfactory_epithelium0.93042134
145MP0004185_abnormal_adipocyte_glucose0.92417793
146MP0009053_abnormal_anal_canal0.91813038
147MP0004924_abnormal_behavior0.91046550
148MP0005386_behavior/neurological_phenoty0.91046550
149MP0008932_abnormal_embryonic_tissue0.90731845
150MP0001529_abnormal_vocalization0.90467022
151MP0004134_abnormal_chest_morphology0.90100002
152MP0003091_abnormal_cell_migration0.89616336
153MP0004087_abnormal_muscle_fiber0.89588619
154MP0002098_abnormal_vibrissa_morphology0.88675850
155MP0000749_muscle_degeneration0.88303556
156MP0002332_abnormal_exercise_endurance0.87966486
157MP0005499_abnormal_olfactory_system0.86668712
158MP0005394_taste/olfaction_phenotype0.86668712
159MP0001243_abnormal_dermal_layer0.85871774
160MP0005369_muscle_phenotype0.85824384
161MP0001944_abnormal_pancreas_morphology0.85230818
162MP0002086_abnormal_extraembryonic_tissu0.84541068
163MP0003137_abnormal_impulse_conducting0.83959132
164MP0000428_abnormal_craniofacial_morphol0.83201816
165MP0002653_abnormal_ependyma_morphology0.83071277
166MP0005464_abnormal_platelet_physiology0.82885341
167MP0003221_abnormal_cardiomyocyte_apopto0.82369318
168MP0005380_embryogenesis_phenotype0.81535943
169MP0001672_abnormal_embryogenesis/_devel0.81535943
170MP0003191_abnormal_cellular_cholesterol0.81450307
171MP0000350_abnormal_cell_proliferation0.81330798
172MP0002938_white_spotting0.80852681
173MP0006072_abnormal_retinal_apoptosis0.80530449
174MP0002638_abnormal_pupillary_reflex0.80235323
175MP0005621_abnormal_cell_physiology0.79635985
176MP0005248_abnormal_Harderian_gland0.79428256
177MP0009333_abnormal_splenocyte_physiolog0.79404213
178MP0003279_aneurysm0.79023186
179MP0003115_abnormal_respiratory_system0.78679168
180MP0003699_abnormal_female_reproductive0.78623380
181MP0002396_abnormal_hematopoietic_system0.78089268
182MP0004085_abnormal_heartbeat0.77557396
183MP0001502_abnormal_circadian_rhythm0.77385241
184MP0002009_preneoplasia0.75023860
185MP0005620_abnormal_muscle_contractility0.74938524
186MP0000358_abnormal_cell_content/0.74917591
187MP0004215_abnormal_myocardial_fiber0.74680413
188MP0001119_abnormal_female_reproductive0.74623672
189MP0008058_abnormal_DNA_repair0.73762781
190MP0003984_embryonic_growth_retardation0.71645050
191MP0005384_cellular_phenotype0.71617881
192MP0002084_abnormal_developmental_patter0.71562357
193MP0000609_abnormal_liver_physiology0.70467747
194MP0001849_ear_inflammation0.70367515

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.25427772
2Degeneration of anterior horn cells (HP:0002398)3.76761224
3Abnormality of the anterior horn cell (HP:0006802)3.76761224
4Curly hair (HP:0002212)3.61463525
5Palmar hyperkeratosis (HP:0010765)3.52945185
6Conjunctival telangiectasia (HP:0000524)3.34876529
7Palmoplantar hyperkeratosis (HP:0000972)3.18972943
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.15857373
9Plantar hyperkeratosis (HP:0007556)3.07952167
10Thick nail (HP:0001805)3.07572835
11Dry hair (HP:0011359)3.00568099
12Ankle clonus (HP:0011448)2.94858236
13Supranuclear gaze palsy (HP:0000605)2.84864615
14Myokymia (HP:0002411)2.77320689
15Eczematoid dermatitis (HP:0000976)2.71191749
16Abnormality of pyrimidine metabolism (HP:0004353)2.70312903
17Hypotrichosis (HP:0001006)2.69404958
18Abnormal umbilical cord blood vessels (HP:0011403)2.64214706
19Single umbilical artery (HP:0001195)2.64214706
20Abnormality of the fetal cardiovascular system (HP:0010948)2.64214706
21Myocardial infarction (HP:0001658)2.63044547
22Neoplasm of the heart (HP:0100544)2.63004339
23Agitation (HP:0000713)2.60985821
24Increased mean platelet volume (HP:0011877)2.59925356
25Alopecia of scalp (HP:0002293)2.59608980
26Pheochromocytoma (HP:0002666)2.59276179
27Erythroderma (HP:0001019)2.57795014
28Ureteral duplication (HP:0000073)2.54769973
29Visual hallucinations (HP:0002367)2.49983639
30Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47412416
31Bladder diverticulum (HP:0000015)2.46738644
32Duplicated collecting system (HP:0000081)2.45164286
33Abnormal platelet volume (HP:0011876)2.41460743
34Hyperacusis (HP:0010780)2.39770299
35Macroorchidism (HP:0000053)2.39597293
36Congenital ichthyosiform erythroderma (HP:0007431)2.38596151
37Type 1 muscle fiber predominance (HP:0003803)2.38252224
38Tongue fasciculations (HP:0001308)2.38208246
39Hypoventilation (HP:0002791)2.36517812
40Insomnia (HP:0100785)2.35323168
41Focal seizures (HP:0007359)2.31677098
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30241966
43Transitional cell carcinoma of the bladder (HP:0006740)2.29945444
44Shallow orbits (HP:0000586)2.29860675
45Buphthalmos (HP:0000557)2.27575930
46Selective tooth agenesis (HP:0001592)2.26562628
47Hypobetalipoproteinemia (HP:0003563)2.25729838
48Hyperlipoproteinemia (HP:0010980)2.25014404
49Sensory axonal neuropathy (HP:0003390)2.24998710
50Limb dystonia (HP:0002451)2.22248758
51Megalencephaly (HP:0001355)2.21387930
52Bladder carcinoma (HP:0002862)2.21357349
53Bladder neoplasm (HP:0009725)2.21357349
54Termporal pattern (HP:0011008)2.20546995
55Insidious onset (HP:0003587)2.20546995
56Protrusio acetabuli (HP:0003179)2.20500066
57Hypoplastic labia majora (HP:0000059)2.20405094
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20046005
59Congenital glaucoma (HP:0001087)2.19755765
60Cerebral aneurysm (HP:0004944)2.19491985
61Upper motor neuron abnormality (HP:0002127)2.17901673
62Pointed chin (HP:0000307)2.17461110
63Abnormality of secondary sexual hair (HP:0009888)2.17377901
64Abnormality of the axillary hair (HP:0100134)2.17377901
65Labial hypoplasia (HP:0000066)2.17163764
66Bowel diverticulosis (HP:0005222)2.16199945
67Neoplasm of the adrenal cortex (HP:0100641)2.16061761
68Cerebral inclusion bodies (HP:0100314)2.15432299
69Renal duplication (HP:0000075)2.15313885
70Leiomyosarcoma (HP:0100243)2.15309119
71Uterine leiomyosarcoma (HP:0002891)2.15309119
72Shoulder girdle muscle weakness (HP:0003547)2.15041126
73Stridor (HP:0010307)2.14311774
74Neuroendocrine neoplasm (HP:0100634)2.13824565
75Intestinal atresia (HP:0011100)2.13689573
76Increased variability in muscle fiber diameter (HP:0003557)2.13549380
77Parakeratosis (HP:0001036)2.12846461
78Muscle fibrillation (HP:0010546)2.12743672
79Hypercortisolism (HP:0001578)2.12588236
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12312377
81Papilledema (HP:0001085)2.11065443
82Neurofibrillary tangles (HP:0002185)2.10327188
83Hematochezia (HP:0002573)2.10114971
84Fragile nails (HP:0001808)2.09867911
85Spinal muscular atrophy (HP:0007269)2.09455308
86Erythema (HP:0010783)2.08649101
87Hypoplastic female external genitalia (HP:0012815)2.07890678
88Ectopic kidney (HP:0000086)2.07460586
89Overriding aorta (HP:0002623)2.06636524
90Upper limb amyotrophy (HP:0009129)2.04773807
91Distal upper limb amyotrophy (HP:0007149)2.04773807
92Depression (HP:0000716)2.04470674
93Impaired proprioception (HP:0010831)2.01940629
94Ectropion (HP:0000656)2.01706700
95Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01196130
96Hypoplasia of the brainstem (HP:0002365)2.01196130
97Menstrual irregularities (HP:0000858)2.00592372
98Premature rupture of membranes (HP:0001788)1.99632002
99Difficulty running (HP:0009046)1.98247842
100White forelock (HP:0002211)1.97657863
101Gaze-evoked nystagmus (HP:0000640)1.96036913
102Abnormal hair laboratory examination (HP:0003328)1.95294148
103Conjunctival hamartoma (HP:0100780)1.95191844
104Chromsome breakage (HP:0040012)1.93815344
105Prolonged partial thromboplastin time (HP:0003645)1.92715766
106Abnormality of the renal collecting system (HP:0004742)1.92199855
107Atrophy/Degeneration involving motor neurons (HP:0007373)1.90786728
108Urinary urgency (HP:0000012)1.89904568
109Urethral obstruction (HP:0000796)1.89370208
110Spontaneous hematomas (HP:0007420)1.89057506
111Elfin facies (HP:0004428)1.88672917
112Flat cornea (HP:0007720)1.88242226
113Conjugated hyperbilirubinemia (HP:0002908)1.88045923
114Abnormality of skeletal muscle fiber size (HP:0012084)1.87897270
115Malignant gastrointestinal tract tumors (HP:0006749)1.87762852
116Gastrointestinal carcinoma (HP:0002672)1.87762852
117Abnormality of the labia majora (HP:0012881)1.87525265
118Hypolipoproteinemia (HP:0010981)1.86078393
119Abnormality of abdominal situs (HP:0011620)1.86009891
120Abdominal situs inversus (HP:0003363)1.86009891
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85875473
122Abnormality of the musculature of the pelvis (HP:0001469)1.85875249
123Abnormality of the hip-girdle musculature (HP:0001445)1.85875249
124Abnormality of the labia minora (HP:0012880)1.84568506
125Scapular winging (HP:0003691)1.84024853
126Impaired vibratory sensation (HP:0002495)1.83882095
127Hemiparesis (HP:0001269)1.83687306
128Truncal ataxia (HP:0002078)1.83160043
129Lissencephaly (HP:0001339)1.82215402
130Apathy (HP:0000741)1.80870155
131Abnormality of dentin (HP:0010299)1.80841210
132Hand muscle atrophy (HP:0009130)1.79757443
133Adducted thumb (HP:0001181)1.79575720
134Pelvic girdle muscle weakness (HP:0003749)1.79432600
135Broad metatarsal (HP:0001783)1.79341208
136Bilateral sensorineural hearing impairment (HP:0008619)1.79247013
137Lower limb muscle weakness (HP:0007340)1.78878061
138Abnormality of chromosome stability (HP:0003220)1.78686901
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77780651
140Pili torti (HP:0003777)1.77439364
141Abnormality of the umbilical cord (HP:0010881)1.76356795
142Focal motor seizures (HP:0011153)1.76211151
143Absent radius (HP:0003974)1.76030511
144Testicular neoplasm (HP:0010788)1.75546739
145Abnormality of the labia (HP:0000058)1.74505009
146Wrist flexion contracture (HP:0001239)1.73960046
147Submucous cleft hard palate (HP:0000176)1.73848759
148Hepatoblastoma (HP:0002884)1.73347553
149Embryonal renal neoplasm (HP:0011794)1.73223993
150Mildly elevated creatine phosphokinase (HP:0008180)1.72285324
151Absent eyelashes (HP:0000561)1.72227800
152Intrahepatic cholestasis (HP:0001406)1.72053916
153Neoplasm of the peripheral nervous system (HP:0100007)1.71892672
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.71644086
155Fair hair (HP:0002286)1.71406995
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71375746
157Corneal erosion (HP:0200020)1.70570103
158Overgrowth (HP:0001548)1.70356691
159Milia (HP:0001056)1.70129053
160Spastic gait (HP:0002064)1.70037985
161Diminished motivation (HP:0000745)1.69740576
162Vascular calcification (HP:0004934)1.69562084
163Ankyloglossia (HP:0010296)1.69524687
164Lower limb amyotrophy (HP:0007210)1.69146121
165Arterial tortuosity (HP:0005116)1.69105114
166Sudden death (HP:0001699)1.68498870
167Action tremor (HP:0002345)1.68459736
168EEG with generalized epileptiform discharges (HP:0011198)1.68255227
169Hypsarrhythmia (HP:0002521)1.68128676
170Amyotrophic lateral sclerosis (HP:0007354)1.67635177
171Secondary amenorrhea (HP:0000869)1.67603050
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67326970
173Dilatation of the ascending aorta (HP:0005111)1.67145583
174Abnormality of calcium-phosphate metabolism (HP:0100530)1.66324855
175Papillary thyroid carcinoma (HP:0002895)1.65924512
176Excessive salivation (HP:0003781)1.64301109
177Drooling (HP:0002307)1.64301109
178Limb-girdle muscle weakness (HP:0003325)1.64273625
179Spastic diplegia (HP:0001264)1.64170350
180Hyperglycemia (HP:0003074)1.64157115
181Hamartoma of the eye (HP:0010568)1.63912309
182Abnormality of methionine metabolism (HP:0010901)1.63544260
183Broad ribs (HP:0000885)1.61979480
184Rapidly progressive (HP:0003678)1.61734539
185Failure to thrive in infancy (HP:0001531)1.61586568
186Hammertoe (HP:0001765)1.61495663
187Akinesia (HP:0002304)1.61278150
188Vascular tortuosity (HP:0004948)1.61267640
189Atonic seizures (HP:0010819)1.61149603
190Epileptiform EEG discharges (HP:0011182)1.60666206
191Striae distensae (HP:0001065)1.60232977
192Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.60126027
193Lymphangioma (HP:0100764)1.60089395
194Abnormality of the calf musculature (HP:0001430)1.59123097
195Prolonged QT interval (HP:0001657)1.58992821
196Large for gestational age (HP:0001520)1.58783645
197Spinal rigidity (HP:0003306)1.58245395
198Torticollis (HP:0000473)1.58127034
199Ankle contracture (HP:0006466)1.56872358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.24989792
2MARK14.07868621
3MKNK23.71389739
4FRK3.27866919
5EIF2AK33.11516075
6WNK33.00601657
7MST42.84333498
8TNIK2.82299503
9TRIB32.72994916
10STK242.56021785
11UHMK12.45103733
12NTRK32.41580002
13MAP3K92.34607073
14ACVR1B2.24528607
15KSR12.22688445
16BUB12.22076625
17PAK62.16763180
18MINK12.13690024
19PRKD32.11979657
20CDK62.11865053
21NEK92.11216160
22KSR22.02510459
23ERBB31.93671873
24LIMK11.93074945
25PAK31.89015654
26PHKG21.89007772
27PHKG11.89007772
28BRSK21.88982708
29NTRK11.88879864
30STK38L1.87187917
31NTRK21.87170803
32MKNK11.82781490
33PLK31.77051016
34PDGFRA1.72333080
35EIF2AK11.69283567
36NLK1.67738089
37MAP3K41.66831178
38TAF11.53285168
39EEF2K1.51732678
40AKT31.48335883
41TTN1.47707078
42SCYL21.46708474
43DYRK21.46630947
44LMTK21.43965820
45TYRO31.42015909
46WEE11.41780724
47SMG11.35648664
48CDK91.35478755
49STK31.34242380
50MAPK151.33713214
51MAPK131.33212183
52TTK1.32797479
53EPHA41.31512629
54CDK51.30960916
55DDR21.28250920
56CAMKK11.28234593
57FGFR31.27595722
58LATS21.26774968
59SIK21.26636358
60BRD41.26286352
61BCR1.25988659
62DMPK1.25979522
63STK101.25748421
64RET1.25667950
65PKN21.25539810
66ZAK1.23992450
67ICK1.20967617
68DAPK21.20402831
69EPHB21.16340646
70MAP3K21.14111455
71CDK141.12320139
72PASK1.10168213
73PRPF4B1.09169967
74MAP3K61.09004300
75WNK41.05579843
76RIPK11.04773608
77TGFBR21.03718531
78TGFBR11.03305518
79CDK181.02844143
80FER1.02778204
81PRKCH1.00111627
82CDK150.98154230
83CSNK1G20.97814333
84PLK10.95195061
85TESK10.94517370
86EIF2AK20.94303688
87MARK20.93430696
88PTK60.92326650
89SIK30.92205889
90SGK20.89902064
91PTK20.89661585
92STK40.88648143
93CSNK1A1L0.84727614
94MAP3K30.83831091
95CDC42BPA0.83021796
96CSNK1G30.82815646
97CDK11A0.82703255
98PNCK0.82557849
99ILK0.82541845
100HIPK20.82205482
101PRKAA20.80209822
102PLK20.79910339
103ROCK10.79745042
104WNK10.79454798
105ROCK20.79147391
106MELK0.79003634
107FGFR20.78796552
108NUAK10.76317243
109DYRK1B0.74612510
110CSNK1G10.72011559
111CAMK1G0.71200306
112SGK30.71137535
113PAK40.70943169
114YES10.69899855
115PTK2B0.69219672
116STK380.68450939
117RPS6KA20.66968155
118VRK10.66477099
119ERBB40.65518407
120MAP2K10.63941772
121CAMKK20.61203493
122PDGFRB0.60649651
123TSSK60.60560440
124ATM0.59298255
125PLK40.58845282
126STK390.58829410
127DYRK1A0.58638445
128RPS6KA40.57880071
129MAP2K70.57752513
130PRKD10.55632963
131FYN0.53987991
132BMPR1B0.51977307
133NEK10.50866965
134SGK4940.50814198
135SGK2230.50814198
136MAP3K100.50577571
137PAK20.49300179
138PRKD20.48552592
139CAMK2A0.48112210
140DAPK30.47147824
141PRKCE0.46323319
142MAP2K30.46147756
143FGFR10.44989623
144CAMK2B0.44945700
145ALK0.44918647
146MAP2K40.44718500
147MTOR0.44252753
148EPHB10.43952916
149ERBB20.43649388
150EPHA30.43565708
151TRPM70.43391194
152TIE10.42471638
153GSK3A0.41957876
154PRKCG0.41755185
155PIK3CG0.41134062
156PKN10.40824513
157OBSCN0.40608557
158CDK40.40594297
159MAP3K10.39915579
160PRKCI0.39882782
161CCNB10.39136455
162CAMK2D0.39118627
163MAPK100.39082110
164JAK10.38631390
165MAP3K50.37260807
166PRKAA10.36253069
167CHEK10.35307033
168GRK10.34885767
169FLT30.33117839
170SRPK10.32669249
171CAMK1D0.31083883
172RPS6KB10.30513997
173TEC0.30064330
174STK110.29706969
175CLK10.29471851
176CDK30.26458180
177CAMK40.22463017

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.86905008
2Vitamin B6 metabolism_Homo sapiens_hsa007502.77446495
3Non-homologous end-joining_Homo sapiens_hsa034502.34023370
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94857093
5p53 signaling pathway_Homo sapiens_hsa041151.92328950
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88724913
7Insulin secretion_Homo sapiens_hsa049111.83934722
8Synaptic vesicle cycle_Homo sapiens_hsa047211.82528236
9Propanoate metabolism_Homo sapiens_hsa006401.81579592
10Circadian entrainment_Homo sapiens_hsa047131.80313560
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78347604
12Dopaminergic synapse_Homo sapiens_hsa047281.74087059
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70108076
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67986300
15GABAergic synapse_Homo sapiens_hsa047271.67723345
16Axon guidance_Homo sapiens_hsa043601.66597216
17Olfactory transduction_Homo sapiens_hsa047401.64310052
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63141559
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61842261
20Long-term potentiation_Homo sapiens_hsa047201.61499348
21Cocaine addiction_Homo sapiens_hsa050301.61486009
22Cholinergic synapse_Homo sapiens_hsa047251.56468859
23Cell cycle_Homo sapiens_hsa041101.56416842
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53419453
25Amphetamine addiction_Homo sapiens_hsa050311.52826883
26Morphine addiction_Homo sapiens_hsa050321.47169839
27Gap junction_Homo sapiens_hsa045401.47063179
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46484913
29Caffeine metabolism_Homo sapiens_hsa002321.46347430
30Dilated cardiomyopathy_Homo sapiens_hsa054141.45772867
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42788431
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42471001
33Glutamatergic synapse_Homo sapiens_hsa047241.41827250
34Type II diabetes mellitus_Homo sapiens_hsa049301.41116260
35Oxytocin signaling pathway_Homo sapiens_hsa049211.37005302
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36008080
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35907679
38Renin secretion_Homo sapiens_hsa049241.35798962
39Nicotine addiction_Homo sapiens_hsa050331.34467697
40Basal transcription factors_Homo sapiens_hsa030221.32927550
41Butanoate metabolism_Homo sapiens_hsa006501.31914108
42Glioma_Homo sapiens_hsa052141.31634742
43Gastric acid secretion_Homo sapiens_hsa049711.30498923
44Selenocompound metabolism_Homo sapiens_hsa004501.30210801
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.26347655
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.25728826
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25403875
48Vibrio cholerae infection_Homo sapiens_hsa051101.25095686
49Estrogen signaling pathway_Homo sapiens_hsa049151.25029386
50Renal cell carcinoma_Homo sapiens_hsa052111.23451020
51Arginine biosynthesis_Homo sapiens_hsa002201.23315809
52GnRH signaling pathway_Homo sapiens_hsa049121.22341049
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20500338
54beta-Alanine metabolism_Homo sapiens_hsa004101.20217178
55Fatty acid degradation_Homo sapiens_hsa000711.20180718
56Long-term depression_Homo sapiens_hsa047301.19965666
57Lysine degradation_Homo sapiens_hsa003101.18883723
58Serotonergic synapse_Homo sapiens_hsa047261.18852297
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.17984181
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15857245
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15307004
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15232177
63Endometrial cancer_Homo sapiens_hsa052131.11010997
64ErbB signaling pathway_Homo sapiens_hsa040121.10967502
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10327340
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09838143
67Inositol phosphate metabolism_Homo sapiens_hsa005621.09034623
68Thyroid cancer_Homo sapiens_hsa052161.08069256
69Fatty acid metabolism_Homo sapiens_hsa012121.07514521
70Melanogenesis_Homo sapiens_hsa049161.07351640
71Focal adhesion_Homo sapiens_hsa045101.05768300
72Pyruvate metabolism_Homo sapiens_hsa006201.05717242
73Sphingolipid metabolism_Homo sapiens_hsa006001.04888796
74Salivary secretion_Homo sapiens_hsa049701.04029602
75Colorectal cancer_Homo sapiens_hsa052101.02435890
76Retinol metabolism_Homo sapiens_hsa008301.01551418
77cAMP signaling pathway_Homo sapiens_hsa040241.01519868
78Fatty acid elongation_Homo sapiens_hsa000620.98979092
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98670319
80VEGF signaling pathway_Homo sapiens_hsa043700.97895173
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96124316
82PPAR signaling pathway_Homo sapiens_hsa033200.94990360
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94687634
84Taste transduction_Homo sapiens_hsa047420.93773390
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93672651
86RNA transport_Homo sapiens_hsa030130.93287248
87TGF-beta signaling pathway_Homo sapiens_hsa043500.92204053
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.91834188
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91039293
90Protein export_Homo sapiens_hsa030600.90639245
91Chronic myeloid leukemia_Homo sapiens_hsa052200.90503766
92mTOR signaling pathway_Homo sapiens_hsa041500.89902888
93Alcoholism_Homo sapiens_hsa050340.88339754
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.88075195
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87384977
96Endocytosis_Homo sapiens_hsa041440.86650894
97Viral myocarditis_Homo sapiens_hsa054160.86516668
98Fatty acid biosynthesis_Homo sapiens_hsa000610.85333351
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85273678
100Cardiac muscle contraction_Homo sapiens_hsa042600.85252070
101Dorso-ventral axis formation_Homo sapiens_hsa043200.84835194
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.84473618
103Calcium signaling pathway_Homo sapiens_hsa040200.83590423
104MicroRNAs in cancer_Homo sapiens_hsa052060.83556306
105Hippo signaling pathway_Homo sapiens_hsa043900.83122576
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82884424
107Oocyte meiosis_Homo sapiens_hsa041140.82452113
108Proteoglycans in cancer_Homo sapiens_hsa052050.80790625
109Tight junction_Homo sapiens_hsa045300.80080101
110Peroxisome_Homo sapiens_hsa041460.79795498
111Wnt signaling pathway_Homo sapiens_hsa043100.79619898
112Hedgehog signaling pathway_Homo sapiens_hsa043400.78578937
113AMPK signaling pathway_Homo sapiens_hsa041520.78518033
114Type I diabetes mellitus_Homo sapiens_hsa049400.78364919
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78314574
116Complement and coagulation cascades_Homo sapiens_hsa046100.78296227
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77677137
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77571771
119MAPK signaling pathway_Homo sapiens_hsa040100.77139611
120Insulin signaling pathway_Homo sapiens_hsa049100.77101971
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77048531
122Biosynthesis of amino acids_Homo sapiens_hsa012300.76901045
123Non-small cell lung cancer_Homo sapiens_hsa052230.76700854
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74139568
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73995910
126Rap1 signaling pathway_Homo sapiens_hsa040150.72993310
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72355932
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.71640288
129Carbon metabolism_Homo sapiens_hsa012000.71168744
130Ras signaling pathway_Homo sapiens_hsa040140.71142035
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70652103
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68577446
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68457068
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67606388
135Glucagon signaling pathway_Homo sapiens_hsa049220.67428758
136Pancreatic cancer_Homo sapiens_hsa052120.66944384
137Thyroid hormone synthesis_Homo sapiens_hsa049180.66862466
138mRNA surveillance pathway_Homo sapiens_hsa030150.65819680
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65443700
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.65310105
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64700754
142Adherens junction_Homo sapiens_hsa045200.64220461
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64214354
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62632789
145Amoebiasis_Homo sapiens_hsa051460.62546462
146Circadian rhythm_Homo sapiens_hsa047100.62442433
147ECM-receptor interaction_Homo sapiens_hsa045120.61444702
148Choline metabolism in cancer_Homo sapiens_hsa052310.61260641
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.60606190
150Prolactin signaling pathway_Homo sapiens_hsa049170.60184432
151Prion diseases_Homo sapiens_hsa050200.59829197
152Pancreatic secretion_Homo sapiens_hsa049720.59818024
153Prostate cancer_Homo sapiens_hsa052150.59603230
154Viral carcinogenesis_Homo sapiens_hsa052030.59014848
155N-Glycan biosynthesis_Homo sapiens_hsa005100.57984679
156Starch and sucrose metabolism_Homo sapiens_hsa005000.57530942
157Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57175343
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56941792
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56646276
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.55655006
161Platelet activation_Homo sapiens_hsa046110.53970893
162Arginine and proline metabolism_Homo sapiens_hsa003300.53970023
163RNA degradation_Homo sapiens_hsa030180.52846256
164FoxO signaling pathway_Homo sapiens_hsa040680.49959956
165Glycerolipid metabolism_Homo sapiens_hsa005610.49866740
166Linoleic acid metabolism_Homo sapiens_hsa005910.48455196
167Ether lipid metabolism_Homo sapiens_hsa005650.48428357
168Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48197366
169Small cell lung cancer_Homo sapiens_hsa052220.47515599
170Fanconi anemia pathway_Homo sapiens_hsa034600.44607558
171Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42624265
172Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41621895
173Tryptophan metabolism_Homo sapiens_hsa003800.41081131
174Sulfur metabolism_Homo sapiens_hsa009200.39638025

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