TRIM38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.33368970
2interferon-gamma secretion (GO:0072643)5.70788519
3intestinal epithelial cell development (GO:0060576)5.52272829
4positive regulation of gamma-delta T cell activation (GO:0046645)5.51685172
5fructose metabolic process (GO:0006000)5.49982934
6regulation of cellular amino acid metabolic process (GO:0006521)5.44135088
7folic acid metabolic process (GO:0046655)5.40541923
8ribosome assembly (GO:0042255)5.38864469
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.28431649
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)5.27626060
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:05.25166229
12negative regulation of cell killing (GO:0031342)5.20592032
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.20592032
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13493118
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)5.12663586
16purine nucleobase biosynthetic process (GO:0009113)4.91963984
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85849261
18folic acid transport (GO:0015884)4.82867366
19antigen processing and presentation of endogenous antigen (GO:0019883)4.79375738
20positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.75681376
21negative regulation of ligase activity (GO:0051352)4.74586753
22negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.74586753
23signal transduction involved in DNA integrity checkpoint (GO:0072401)4.71010072
24signal transduction involved in DNA damage checkpoint (GO:0072422)4.71010072
25signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.69577710
26signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.69577710
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.69577710
28regulation of B cell receptor signaling pathway (GO:0050855)4.63039220
29signal transduction involved in cell cycle checkpoint (GO:0072395)4.62521359
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.61851008
31nucleobase biosynthetic process (GO:0046112)4.58499796
32rRNA modification (GO:0000154)4.55339461
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52876330
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.51843938
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.51843938
36cellular extravasation (GO:0045123)4.51047966
37positive regulation of ligase activity (GO:0051351)4.49919359
38regulation of histone H3-K27 methylation (GO:0061085)4.44810610
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.25519338
40positive regulation by organism of defense response of other organism involved in symbiotic interact4.25519338
41modulation by symbiont of host immune response (GO:0052553)4.25519338
42positive regulation by symbiont of host defense response (GO:0052509)4.25519338
43modulation by symbiont of host defense response (GO:0052031)4.25519338
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.25519338
45amino sugar catabolic process (GO:0046348)4.25445069
46immunoglobulin mediated immune response (GO:0016064)4.17947452
47regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.13553707
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.10342493
49regulation of ubiquitin-protein transferase activity (GO:0051438)4.09695244
50lung-associated mesenchyme development (GO:0060484)4.09571559
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09326350
52regulation of gamma-delta T cell activation (GO:0046643)4.05712154
53mitotic metaphase plate congression (GO:0007080)4.01028167
54regulation of cellular amine metabolic process (GO:0033238)3.96151749
55macrophage activation involved in immune response (GO:0002281)3.94066585
56regulation of ligase activity (GO:0051340)3.90934387
57formation of translation preinitiation complex (GO:0001731)3.89332948
58positive regulation of cell cycle arrest (GO:0071158)3.88060781
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.86472870
60detection of other organism (GO:0098543)3.82537984
61response to type I interferon (GO:0034340)3.79682501
62negative regulation of interleukin-12 production (GO:0032695)3.79290511
63type I interferon signaling pathway (GO:0060337)3.75597915
64cellular response to type I interferon (GO:0071357)3.75597915
65B cell receptor signaling pathway (GO:0050853)3.73489749
66neutrophil activation involved in immune response (GO:0002283)3.73267692
67L-methionine salvage (GO:0071267)3.71045030
68L-methionine biosynthetic process (GO:0071265)3.71045030
69amino acid salvage (GO:0043102)3.71045030
70response to peptidoglycan (GO:0032494)3.69238398
71regulation of gamma-delta T cell differentiation (GO:0045586)3.68680167
72detection of bacterium (GO:0016045)3.63343555
73negative thymic T cell selection (GO:0045060)3.61993270
74negative T cell selection (GO:0043383)3.61126144
75interferon-gamma-mediated signaling pathway (GO:0060333)3.58369407
76DNA replication checkpoint (GO:0000076)3.58059477
77negative regulation of T cell mediated immunity (GO:0002710)3.56363201
78regulation of interferon-beta biosynthetic process (GO:0045357)3.54437305
79regulation of translation in response to stress (GO:0043555)3.53719951
80regulation of antigen processing and presentation (GO:0002577)3.51998836
81detection of molecule of bacterial origin (GO:0032490)3.51865279
82microglial cell activation (GO:0001774)3.50802184
83nucleoside diphosphate biosynthetic process (GO:0009133)3.50585765
84DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.49029103
85negative regulation of lymphocyte mediated immunity (GO:0002707)3.48151073
86N-acetylneuraminate metabolic process (GO:0006054)3.46067176
87detection of external biotic stimulus (GO:0098581)3.45022601
88T cell migration (GO:0072678)3.44876333
89blastocyst development (GO:0001824)3.44545957
90positive thymic T cell selection (GO:0045059)3.43537847
91ribosome biogenesis (GO:0042254)3.42795179
92modified amino acid transport (GO:0072337)3.42559155
93DNA deamination (GO:0045006)3.41821641
94maturation of 5.8S rRNA (GO:0000460)3.40401880
95GDP-mannose metabolic process (GO:0019673)3.36428355
96regulation of mitochondrial translation (GO:0070129)3.35999842
97ADP metabolic process (GO:0046031)3.35970282
98positive regulation of interferon-alpha production (GO:0032727)3.32031871
99cell cycle G1/S phase transition (GO:0044843)3.31320798
100G1/S transition of mitotic cell cycle (GO:0000082)3.31320798
101response to interleukin-15 (GO:0070672)3.31019541
102regulation of translational termination (GO:0006449)3.30659118
103myeloid cell activation involved in immune response (GO:0002275)3.28487616
104negative regulation of protein ubiquitination (GO:0031397)3.26482619
105intestinal absorption (GO:0050892)3.26451378
106cyclooxygenase pathway (GO:0019371)3.26230681
107oligosaccharide catabolic process (GO:0009313)3.23184939
108germinal center formation (GO:0002467)3.23054313
109leukocyte aggregation (GO:0070486)3.22988208
110regulation of interferon-alpha production (GO:0032647)3.21978168
111regulation of B cell differentiation (GO:0045577)3.20938690
112cellular response to interleukin-15 (GO:0071350)3.20509753
113positive regulation of B cell differentiation (GO:0045579)3.20084919
114B cell mediated immunity (GO:0019724)3.19910349
115establishment of protein localization to mitochondrial membrane (GO:0090151)3.17169029
116signal transduction in response to DNA damage (GO:0042770)3.16905372
117nucleobase-containing small molecule interconversion (GO:0015949)3.16778904
118keratinocyte development (GO:0003334)3.14468730
119positive T cell selection (GO:0043368)3.14256764
120neutrophil activation (GO:0042119)3.12939499
121regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12839367
122regulation of cell cycle arrest (GO:0071156)3.11891384
123regulation of alpha-beta T cell proliferation (GO:0046640)3.10556713
124positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10001247
125antigen processing and presentation via MHC class Ib (GO:0002475)3.09542256
126negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.09025666
127rRNA methylation (GO:0031167)3.08831072
128transcription elongation from RNA polymerase I promoter (GO:0006362)3.08296290
129defense response to protozoan (GO:0042832)3.08080242
130regulation of regulatory T cell differentiation (GO:0045589)3.06805034
131methionine metabolic process (GO:0006555)3.06486830
132methionine biosynthetic process (GO:0009086)3.06250286
133macrophage activation (GO:0042116)3.06080336
1347-methylguanosine mRNA capping (GO:0006370)3.05348816
135negative regulation of cell cycle G1/S phase transition (GO:1902807)3.05257058
136negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.05257058
137response to host immune response (GO:0052572)3.05253512
138response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05253512
139DNA damage induced protein phosphorylation (GO:0006975)3.03831124
140positive regulation of mast cell activation (GO:0033005)3.03702718
141antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.03157144
142regulation of mast cell activation (GO:0033003)3.01752077
143NADH metabolic process (GO:0006734)3.01389047
144detection of biotic stimulus (GO:0009595)3.01245412
145negative regulation of leukocyte mediated immunity (GO:0002704)2.99916529
146DNA damage response, detection of DNA damage (GO:0042769)2.99067339
147metaphase plate congression (GO:0051310)2.98795990
148mast cell activation (GO:0045576)2.97702364
149sulfur amino acid biosynthetic process (GO:0000097)2.97701955
150negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97135290
151neutrophil mediated immunity (GO:0002446)2.96722774
152cellular response to exogenous dsRNA (GO:0071360)2.96068640
153positive regulation of antigen processing and presentation (GO:0002579)2.96029739
154regulation of T cell mediated cytotoxicity (GO:0001914)2.95765657
155regulation of germinal center formation (GO:0002634)2.95730365
156galactose catabolic process (GO:0019388)2.95249213
157regulation of T cell tolerance induction (GO:0002664)2.94396850
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93395790
159negative regulation of T-helper cell differentiation (GO:0045623)2.93395790
160termination of RNA polymerase I transcription (GO:0006363)2.93064165
161tolerance induction (GO:0002507)2.91854725
162respiratory burst (GO:0045730)2.91656832
163response to protozoan (GO:0001562)2.90790497
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90689940
165positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.90237522
166meiosis I (GO:0007127)2.89276739
167positive regulation of interferon-beta production (GO:0032728)2.88775876
168granulocyte activation (GO:0036230)2.88611870
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88419078
170regulation of tolerance induction (GO:0002643)2.88320299
171RNA capping (GO:0036260)2.87618825
1727-methylguanosine RNA capping (GO:0009452)2.87618825
173production of molecular mediator involved in inflammatory response (GO:0002532)2.87366119
174activated T cell proliferation (GO:0050798)2.87211532
175termination of RNA polymerase III transcription (GO:0006386)2.86447524
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.86447524
177L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86063823
178regulation of spindle organization (GO:0090224)2.85785116
179T cell selection (GO:0045058)2.85603293
180transcription from RNA polymerase I promoter (GO:0006360)2.84743449
181positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82828464
182interferon-gamma production (GO:0032609)2.82485438
183ribosomal large subunit biogenesis (GO:0042273)2.82453793
184positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81802085
185establishment of chromosome localization (GO:0051303)2.81740556
186response to host (GO:0075136)2.81511736
187response to host defenses (GO:0052200)2.81511736
188response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81511736
189water-soluble vitamin biosynthetic process (GO:0042364)2.80934985
190protein localization to kinetochore (GO:0034501)2.80365954
191CDP-diacylglycerol metabolic process (GO:0046341)2.79392267
192regulation of double-strand break repair via homologous recombination (GO:0010569)2.79377930
193regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79070064
194regulation of interleukin-12 biosynthetic process (GO:0045075)2.78561303
195leukocyte degranulation (GO:0043299)2.78422870
196attachment of spindle microtubules to kinetochore (GO:0008608)2.77118309
197CENP-A containing nucleosome assembly (GO:0034080)2.77088919
198regulation of mast cell degranulation (GO:0043304)2.74083727
199negative regulation of innate immune response (GO:0045824)2.73999797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.76875477
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.64110854
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.45918019
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28653576
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.27785165
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.13084863
7E2F7_22180533_ChIP-Seq_HELA_Human3.90572915
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.90177390
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.82505769
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82000690
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.74002082
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.70938255
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.56532019
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.52165743
15GABP_17652178_ChIP-ChIP_JURKAT_Human3.49905032
16MYC_18555785_ChIP-Seq_MESCs_Mouse3.45802574
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13429314
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13130054
19IRF8_27001747_Chip-Seq_BMDM_Mouse3.08387119
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98778685
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95048562
22RUNX_20019798_ChIP-Seq_JUKART_Human2.91799668
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76414984
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76016409
25AR_21909140_ChIP-Seq_LNCAP_Human2.68574971
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68507055
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62148194
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.61325269
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.51336082
30MYB_26560356_Chip-Seq_TH2_Human2.49681950
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49678998
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47380078
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46153727
34NANOG_18555785_ChIP-Seq_MESCs_Mouse2.44036734
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.30246658
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29823652
37SCL_19346495_ChIP-Seq_HPC-7_Human2.27929018
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27205749
39E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26171058
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23928083
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23029487
42MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19112809
43* VDR_23849224_ChIP-Seq_CD4+_Human2.18702795
44STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18304803
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08948824
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05711503
47NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05459514
48VDR_24787735_ChIP-Seq_THP-1_Human2.04571236
49* SPI1_23547873_ChIP-Seq_NB4_Human2.03607290
50SPI1_23127762_ChIP-Seq_K562_Human2.02768741
51* MYB_26560356_Chip-Seq_TH1_Human2.02304195
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02297563
53E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00060341
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94592941
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94492915
56* VDR_24763502_ChIP-Seq_THP-1_Human1.92745982
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92196607
58DCP1A_22483619_ChIP-Seq_HELA_Human1.91937019
59GATA3_27048872_Chip-Seq_THYMUS_Human1.91624689
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90517815
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86460557
62ZNF263_19887448_ChIP-Seq_K562_Human1.85782542
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.85164414
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83641496
65GABP_19822575_ChIP-Seq_HepG2_Human1.81999925
66MAF_26560356_Chip-Seq_TH1_Human1.77565950
67* GATA3_26560356_Chip-Seq_TH2_Human1.76236265
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75039132
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73420750
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72988297
71XRN2_22483619_ChIP-Seq_HELA_Human1.66808860
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59131992
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57110032
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56365441
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56293563
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55468897
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53680693
78* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52760156
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.51349912
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.51105898
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.51085186
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50913559
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50784927
84FOXP3_21729870_ChIP-Seq_TREG_Human1.50092287
85UTX_26944678_Chip-Seq_JUKART_Human1.48283391
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47908571
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45670121
88KDM5A_27292631_Chip-Seq_BREAST_Human1.45524231
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44839493
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.44818127
91VDR_21846776_ChIP-Seq_THP-1_Human1.44108730
92TTF2_22483619_ChIP-Seq_HELA_Human1.44077436
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.42387519
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41184871
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40667259
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.38309629
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37403109
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37237112
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36773211
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35251651
101KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32039441
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31403105
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30782957
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30588727
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30136909
106KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27717466
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26711373
108GATA1_22025678_ChIP-Seq_K562_Human1.26160494
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23741584
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22651534
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21396666
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21010244
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19274367
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19011559
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18688999
116PU_27001747_Chip-Seq_BMDM_Mouse1.18154492
117MAF_26560356_Chip-Seq_TH2_Human1.17380030
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16995665
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.15501650
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15401705
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15177959
122* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13915301
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.13040264
124GATA1_19941826_ChIP-Seq_K562_Human1.12925694
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12792858
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12408915
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.12272264
128GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10896381
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10248147
130CIITA_25753668_ChIP-Seq_RAJI_Human1.09642797
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09134083
132GATA1_26923725_Chip-Seq_HPCs_Mouse1.07717587
133ELK1_19687146_ChIP-ChIP_HELA_Human1.04976664
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04949635
135MYC_22102868_ChIP-Seq_BL_Human1.04898833
136SMRT_27268052_Chip-Seq_Bcells_Human1.04510354
137RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04413481
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02420271
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00905193
140* GATA2_19941826_ChIP-Seq_K562_Human1.00536162
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99148463
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98951099
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98856828
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98218348
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98100861
146NANOG_21062744_ChIP-ChIP_HESCs_Human0.97734566
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95956018
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94940610
149* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94061435
150PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91168461
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91082298
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91019296
153TCF7_22412390_ChIP-Seq_EML_Mouse0.90894765
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90425218
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89949518
156* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89196730
157SOX17_20123909_ChIP-Seq_XEN_Mouse0.89123884
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87999213
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87978026
160SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87580496
161FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86263423
162KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86035569
163POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85866788
164TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85565811
165KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85204525
166HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84439391
167NOTCH1_21737748_ChIP-Seq_TLL_Human0.84363501
168ATF3_27146783_Chip-Seq_COLON_Human0.84203967
169SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83966408
170PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83225224
171NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81611862
172MYC_18940864_ChIP-ChIP_HL60_Human0.80664313
173YY1_22570637_ChIP-Seq_MALME-3M_Human0.80265187
174CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79925578
175KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79074708
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79074708
177FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78170329
178RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76989765
179GATA3_26560356_Chip-Seq_TH1_Human0.76764187
180IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76288125
181STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75984481
182EGR1_19374776_ChIP-ChIP_THP-1_Human0.75777752
183STAT1_20625510_ChIP-Seq_HELA_Human0.75536301
184RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74102451
185CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74004405
186JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73933998
187* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71511325
188SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71422184
189PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70712169
190PRDM14_20953172_ChIP-Seq_ESCs_Human0.70223415
191KDM2B_26808549_Chip-Seq_DND41_Human0.68678372
192EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67469969
193FOXO3_23340844_ChIP-Seq_DLD1_Human0.67433219
194LXR_22158963_ChIP-Seq_LIVER_Mouse0.67259694
195ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.66677144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.56447947
2MP0003718_maternal_effect4.92109879
3MP0003111_abnormal_nucleus_morphology4.53911141
4MP0001835_abnormal_antigen_presentation4.36573950
5MP0003724_increased_susceptibility_to4.35929340
6MP0009840_abnormal_foam_cell4.32392104
7MP0004957_abnormal_blastocyst_morpholog3.98765068
8MP0003436_decreased_susceptibility_to3.63994007
9MP0005671_abnormal_response_to3.26794550
10MP0008260_abnormal_autophagy3.21490934
11MP0000685_abnormal_immune_system3.19191601
12MP0001800_abnormal_humoral_immune3.18080928
13MP0005387_immune_system_phenotype3.03813013
14MP0001790_abnormal_immune_system3.03813013
15MP0003806_abnormal_nucleotide_metabolis3.01326629
16MP0009785_altered_susceptibility_to2.92130246
17MP0005000_abnormal_immune_tolerance2.90052344
18MP0005360_urolithiasis2.86897327
19MP0003303_peritoneal_inflammation2.86733492
20MP0003878_abnormal_ear_physiology2.81726413
21MP0005377_hearing/vestibular/ear_phenot2.81726413
22MP0002419_abnormal_innate_immunity2.76769521
23MP0005451_abnormal_body_composition2.71288540
24MP0002723_abnormal_immune_serum2.69360724
25MP0005025_abnormal_response_to2.68874809
26MP0003763_abnormal_thymus_physiology2.66598535
27MP0003077_abnormal_cell_cycle2.66172693
28MP0002452_abnormal_antigen_presenting2.65608392
29MP0002148_abnormal_hypersensitivity_rea2.62540171
30MP0002420_abnormal_adaptive_immunity2.48339333
31MP0001819_abnormal_immune_cell2.45979178
32MP0004019_abnormal_vitamin_homeostasis2.40155778
33MP0010094_abnormal_chromosome_stability2.37702344
34MP0001666_abnormal_nutrient_absorption2.28606812
35MP0006082_CNS_inflammation2.25812546
36MP0008932_abnormal_embryonic_tissue2.22280241
37MP0005395_other_phenotype2.10423654
38MP0002138_abnormal_hepatobiliary_system2.03743837
39MP0008058_abnormal_DNA_repair1.99688539
40MP0003300_gastrointestinal_ulcer1.96816235
41MP0002166_altered_tumor_susceptibility1.96200831
42MP0010155_abnormal_intestine_physiology1.94251374
43MP0005464_abnormal_platelet_physiology1.94232491
44MP0002405_respiratory_system_inflammati1.93099880
45MP0001533_abnormal_skeleton_physiology1.91656821
46MP0000716_abnormal_immune_system1.88009243
47MP0002398_abnormal_bone_marrow1.87681793
48MP0003315_abnormal_perineum_morphology1.87074697
49MP0001845_abnormal_inflammatory_respons1.80574865
50MP0003172_abnormal_lysosome_physiology1.80183108
51MP0004264_abnormal_extraembryonic_tissu1.79757332
52MP0005666_abnormal_adipose_tissue1.79745857
53MP0005670_abnormal_white_adipose1.78783233
54MP0004947_skin_inflammation1.78218033
55MP0001730_embryonic_growth_arrest1.77675854
56MP0010352_gastrointestinal_tract_polyps1.72392187
57MP0003786_premature_aging1.71357369
58MP0009764_decreased_sensitivity_to1.66432866
59MP0004185_abnormal_adipocyte_glucose1.65354949
60MP0003646_muscle_fatigue1.65258962
61MP0000689_abnormal_spleen_morphology1.64542163
62MP0003950_abnormal_plasma_membrane1.62918835
63MP0000569_abnormal_digit_pigmentation1.59557537
64MP0005310_abnormal_salivary_gland1.52921323
65MP0002722_abnormal_immune_system1.51773487
66MP0000490_abnormal_crypts_of1.51411638
67MP0002653_abnormal_ependyma_morphology1.51345261
68MP0002006_tumorigenesis1.49775180
69MP0008057_abnormal_DNA_replication1.45631137
70MP0008875_abnormal_xenobiotic_pharmacok1.44280269
71MP0002429_abnormal_blood_cell1.43828484
72MP0003567_abnormal_fetal_cardiomyocyte1.41321461
73MP0008469_abnormal_protein_level1.40552256
74MP0008877_abnormal_DNA_methylation1.38432310
75MP0003045_fibrosis1.33452297
76MP0005332_abnormal_amino_acid1.32794679
77MP0001727_abnormal_embryo_implantation1.31551036
78MP0001853_heart_inflammation1.30300871
79MP0000703_abnormal_thymus_morphology1.28311790
80MP0002396_abnormal_hematopoietic_system1.27774660
81MP0003329_amyloid_beta_deposits1.27542307
82MP0003828_pulmonary_edema1.26931267
83MP0004883_abnormal_blood_vessel1.25825003
84MP0009697_abnormal_copulation1.24715157
85MP0005085_abnormal_gallbladder_physiolo1.21704928
86MP0002139_abnormal_hepatobiliary_system1.21584309
87MP0003866_abnormal_defecation1.21126698
88MP0000465_gastrointestinal_hemorrhage1.20502148
89MP0001873_stomach_inflammation1.18758531
90MP0002933_joint_inflammation1.17558723
91MP0006035_abnormal_mitochondrial_morpho1.16758416
92MP0002998_abnormal_bone_remodeling1.16556517
93MP0005164_abnormal_response_to1.15502361
94MP0009278_abnormal_bone_marrow1.13972448
95MP0000350_abnormal_cell_proliferation1.12590440
96MP0001851_eye_inflammation1.11890481
97MP0002132_abnormal_respiratory_system1.11875777
98MP0003938_abnormal_ear_development1.11700008
99MP0001756_abnormal_urination1.11195659
100MP0001672_abnormal_embryogenesis/_devel1.09452012
101MP0005380_embryogenesis_phenotype1.09452012
102MP0008007_abnormal_cellular_replicative1.09317363
103MP0003879_abnormal_hair_cell1.08151917
104MP0003656_abnormal_erythrocyte_physiolo1.04482383
105MP0002080_prenatal_lethality0.99073801
106MP0003699_abnormal_female_reproductive0.98770488
107MP0000015_abnormal_ear_pigmentation0.98247881
108MP0005075_abnormal_melanosome_morpholog0.97779890
109MP0003183_abnormal_peptide_metabolism0.97383282
110MP0000477_abnormal_intestine_morphology0.96359691
111MP0000858_altered_metastatic_potential0.95423957
112MP0003252_abnormal_bile_duct0.93852835
113MP0005389_reproductive_system_phenotype0.93395177
114MP0001929_abnormal_gametogenesis0.91704032
115MP0001919_abnormal_reproductive_system0.91369540
116MP0005621_abnormal_cell_physiology0.91305216
117MP0002210_abnormal_sex_determination0.90705132
118MP0001542_abnormal_bone_strength0.90674141
119MP0001697_abnormal_embryo_size0.90003922
120MP0001986_abnormal_taste_sensitivity0.89109464
121MP0003195_calcinosis0.88799775
122MP0000462_abnormal_digestive_system0.88480135
123MP0003075_altered_response_to0.88475781
124MP0000358_abnormal_cell_content/0.88208591
125MP0009763_increased_sensitivity_to0.88029814
126MP0005166_decreased_susceptibility_to0.87827436
127MP0003186_abnormal_redox_activity0.87543704
128MP0002088_abnormal_embryonic_growth/wei0.87321391
129MP0000627_abnormal_mammary_gland0.87300164
130MP0003984_embryonic_growth_retardation0.85653554
131MP0002876_abnormal_thyroid_physiology0.85520962
132MP0001764_abnormal_homeostasis0.84956416
133MP0001440_abnormal_grooming_behavior0.83015663
134MP0002277_abnormal_respiratory_mucosa0.82854386
135MP0001145_abnormal_male_reproductive0.82612081
136MP0001663_abnormal_digestive_system0.81494754
137MP0010329_abnormal_lipoprotein_level0.81120268
138MP0000249_abnormal_blood_vessel0.80713245
139MP0003448_altered_tumor_morphology0.80658151
140MP0000653_abnormal_sex_gland0.80646487
141MP0009643_abnormal_urine_homeostasis0.79964431
142MP0002796_impaired_skin_barrier0.79885588
143MP0005384_cellular_phenotype0.77976341
144MP0005390_skeleton_phenotype0.77918505
145MP0002085_abnormal_embryonic_tissue0.77798856
146MP0004130_abnormal_muscle_cell0.77444810
147MP0010234_abnormal_vibrissa_follicle0.77427800
148MP0000313_abnormal_cell_death0.76723999
149MP0009765_abnormal_xenobiotic_induced0.76611335
150MP0005319_abnormal_enzyme/_coenzyme0.76247832
151MP0004381_abnormal_hair_follicle0.75157350
152MP0004043_abnormal_pH_regulation0.74607217
153MP0002086_abnormal_extraembryonic_tissu0.74369209
154MP0003191_abnormal_cellular_cholesterol0.72761478
155MP0000537_abnormal_urethra_morphology0.72130744
156MP0004147_increased_porphyrin_level0.72018265
157MP0004808_abnormal_hematopoietic_stem0.71682473
158MP0000343_altered_response_to0.71660657
159MP0005375_adipose_tissue_phenotype0.70085091
160MP0000604_amyloidosis0.69860056
161MP0004510_myositis0.69817027
162MP0005058_abnormal_lysosome_morphology0.69391220
163MP0005174_abnormal_tail_pigmentation0.68093725
164MP0002136_abnormal_kidney_physiology0.67620010
165MP0001849_ear_inflammation0.67256460
166MP0002269_muscular_atrophy0.67093526
167MP0003868_abnormal_feces_composition0.66902414
168MP0002019_abnormal_tumor_incidence0.66787828
169MP0008004_abnormal_stomach_pH0.66666055
170MP0005266_abnormal_metabolism0.65582749
171MP0001661_extended_life_span0.65490163
172MP0002161_abnormal_fertility/fecundity0.64832477
173MP0005397_hematopoietic_system_phenotyp0.62795930
174MP0001545_abnormal_hematopoietic_system0.62795930
175MP0009333_abnormal_splenocyte_physiolog0.62654520
176MP0001119_abnormal_female_reproductive0.62325733
177MP0006036_abnormal_mitochondrial_physio0.61679476
178MP0005408_hypopigmentation0.61184286
179MP0009115_abnormal_fat_cell0.60449873
180MP0005083_abnormal_biliary_tract0.60185869
181MP0003795_abnormal_bone_structure0.59502882
182MP0000371_diluted_coat_color0.58931213
183MP0002009_preneoplasia0.57746703
184MP0004484_altered_response_of0.56689606
185MP0002332_abnormal_exercise_endurance0.55948821
186MP0005167_abnormal_blood-brain_barrier0.54485295
187MP0006054_spinal_hemorrhage0.53755096

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.91965089
2Eczematoid dermatitis (HP:0000976)4.91519821
3Elevated erythrocyte sedimentation rate (HP:0003565)4.88893641
4Myositis (HP:0100614)4.80842233
5Breast hypoplasia (HP:0003187)4.80343132
6Recurrent bacterial skin infections (HP:0005406)4.76816921
7Recurrent abscess formation (HP:0002722)4.61088320
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.52724475
9Retrobulbar optic neuritis (HP:0100654)4.47566239
10Optic neuritis (HP:0100653)4.47566239
11Orchitis (HP:0100796)4.43436092
12Recurrent fungal infections (HP:0002841)4.42190263
13Rough bone trabeculation (HP:0100670)4.22618472
14T lymphocytopenia (HP:0005403)4.13244470
15Proximal tubulopathy (HP:0000114)4.10184405
16Carpal bone hypoplasia (HP:0001498)4.04919517
17Abnormality of T cell number (HP:0011839)4.04640990
18Mediastinal lymphadenopathy (HP:0100721)3.97097642
19Chronic mucocutaneous candidiasis (HP:0002728)3.95619334
20Recurrent cutaneous fungal infections (HP:0011370)3.95619334
21Ureteral duplication (HP:0000073)3.90729108
22Abnormality of macrophages (HP:0004311)3.87210037
23Megaloblastic anemia (HP:0001889)3.85343455
24Meningitis (HP:0001287)3.82480339
25Cerebral hypomyelination (HP:0006808)3.77549434
26Pulmonary infiltrates (HP:0002113)3.74995663
27Nausea (HP:0002018)3.69478397
28Vasculitis (HP:0002633)3.69155246
29Recurrent skin infections (HP:0001581)3.61909850
30Birth length less than 3rd percentile (HP:0003561)3.59400774
31Panhypogammaglobulinemia (HP:0003139)3.57660841
32Gastrointestinal infarctions (HP:0005244)3.47332420
33Spontaneous hematomas (HP:0007420)3.46951355
34Encephalitis (HP:0002383)3.46365420
35Recurrent gram-negative bacterial infections (HP:0005420)3.46154710
36Hyperglycinuria (HP:0003108)3.44246784
37Ileus (HP:0002595)3.44054765
38Abnormality of T cells (HP:0002843)3.41752702
39Recurrent viral infections (HP:0004429)3.36258164
40Hemoptysis (HP:0002105)3.30981267
41Aplasia/Hypoplasia involving the musculature (HP:0001460)3.30572013
42Abnormality of the umbilical cord (HP:0010881)3.29662102
43Keratoconjunctivitis sicca (HP:0001097)3.22387966
44Obstructive lung disease (HP:0006536)3.18587529
45Chronic obstructive pulmonary disease (HP:0006510)3.18587529
46Secondary amenorrhea (HP:0000869)3.11439580
47Leukocytosis (HP:0001974)3.10124571
48Keratoconjunctivitis (HP:0001096)3.09780872
49Abnormal trabecular bone morphology (HP:0100671)3.08242812
50Abnormality of glycine metabolism (HP:0010895)3.05240027
51Abnormality of serine family amino acid metabolism (HP:0010894)3.05240027
52Pustule (HP:0200039)3.01677157
53Gingival bleeding (HP:0000225)2.97827729
54Chest pain (HP:0100749)2.96754715
55Abnormality of T cell physiology (HP:0011840)2.96213149
56Autoimmune hemolytic anemia (HP:0001890)2.95438717
57Multiple enchondromatosis (HP:0005701)2.95272219
58Progressive muscle weakness (HP:0003323)2.93467844
59Premature ovarian failure (HP:0008209)2.91626341
60Patent foramen ovale (HP:0001655)2.90532140
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88575702
62Dicarboxylic aciduria (HP:0003215)2.88575702
63Hyperglycinemia (HP:0002154)2.87623763
64Eosinophilia (HP:0001880)2.84712196
65Abnormality of the vitamin B12 metabolism (HP:0004341)2.82050095
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.81848550
67IgG deficiency (HP:0004315)2.81359937
68Agammaglobulinemia (HP:0004432)2.80985516
69Recurrent bronchitis (HP:0002837)2.79199366
70Prolonged bleeding time (HP:0003010)2.77104690
71Gingivitis (HP:0000230)2.76975705
72Abnormality of the pleura (HP:0002103)2.75940782
73Inflammation of the large intestine (HP:0002037)2.74138305
74Increased IgE level (HP:0003212)2.74106548
75Urticaria (HP:0001025)2.73827501
76Epistaxis (HP:0000421)2.73494523
77Abnormality of the anterior horn cell (HP:0006802)2.71900961
78Degeneration of anterior horn cells (HP:0002398)2.71900961
79Methylmalonic aciduria (HP:0012120)2.69873751
80Abnormality of the fetal cardiovascular system (HP:0010948)2.66428520
81Abnormal umbilical cord blood vessels (HP:0011403)2.66428520
82Single umbilical artery (HP:0001195)2.66428520
83Abnormality of liposaccharide metabolism (HP:0010968)2.65857652
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.65857652
85Abnormality of glycolipid metabolism (HP:0010969)2.65857652
86Abnormality of alanine metabolism (HP:0010916)2.61297871
87Hyperalaninemia (HP:0003348)2.61297871
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61297871
89Abnormality of serum amino acid levels (HP:0003112)2.60990686
90Hyperactive renin-angiotensin system (HP:0000841)2.60238653
91Colitis (HP:0002583)2.58877052
92Arterial thrombosis (HP:0004420)2.58674492
93Absent radius (HP:0003974)2.58632505
94Hypobetalipoproteinemia (HP:0003563)2.57940315
95Abnormality of vitamin B metabolism (HP:0004340)2.57317594
96Poor head control (HP:0002421)2.56026461
97Progressive external ophthalmoplegia (HP:0000590)2.54010931
98Aplasia/Hypoplasia of the patella (HP:0006498)2.53348702
99Prolonged neonatal jaundice (HP:0006579)2.52771128
100Glycosuria (HP:0003076)2.52456880
101Abnormality of urine glucose concentration (HP:0011016)2.52456880
102Impulsivity (HP:0100710)2.50521763
103Episodic fever (HP:0001954)2.50125528
104Lymphopenia (HP:0001888)2.49612837
105Gastrointestinal inflammation (HP:0004386)2.49543469
106Abnormality of eosinophils (HP:0001879)2.47344266
107Pulmonary embolism (HP:0002204)2.47105437
108Cellulitis (HP:0100658)2.46861139
109Increased IgM level (HP:0003496)2.46634001
110Autoimmune thrombocytopenia (HP:0001973)2.44221484
111Agnosia (HP:0010524)2.44031842
112Spinal muscular atrophy (HP:0007269)2.42623297
113Patellar aplasia (HP:0006443)2.42541321
114Absent forearm bone (HP:0003953)2.40500230
115Aplasia involving forearm bones (HP:0009822)2.40500230
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39269490
117Abnormalities of placenta or umbilical cord (HP:0001194)2.39092534
118Anorexia (HP:0002039)2.38630066
119Absent hand (HP:0004050)2.37851867
120Hyperglycemia (HP:0003074)2.37562556
121Hypochromic anemia (HP:0001931)2.37218481
122Increased cerebral lipofuscin (HP:0011813)2.35926603
123Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35909731
124Abnormality of B cell number (HP:0010975)2.35875035
125Congenital malformation of the right heart (HP:0011723)2.35545775
126Double outlet right ventricle (HP:0001719)2.35545775
127Hematochezia (HP:0002573)2.34549959
128Abnormality of cells of the lymphoid lineage (HP:0012140)2.34233379
129Granulocytopenia (HP:0001913)2.33828860
130Chronic diarrhea (HP:0002028)2.33316740
131Thyroiditis (HP:0100646)2.33262752
132Congenital, generalized hypertrichosis (HP:0004540)2.32584353
133Increased neuronal autofluorescent lipopigment (HP:0002074)2.30267432
134Hypergammaglobulinemia (HP:0010702)2.29744086
135Sparse eyelashes (HP:0000653)2.28378868
136Generalized aminoaciduria (HP:0002909)2.28253474
137CNS hypomyelination (HP:0003429)2.26789138
138Abnormality of vitamin metabolism (HP:0100508)2.25980442
139Homocystinuria (HP:0002156)2.25529135
140Abnormality of homocysteine metabolism (HP:0010919)2.25529135
141Abnormality of the prostate (HP:0008775)2.25506392
142Gangrene (HP:0100758)2.24388563
143Gastrointestinal stroma tumor (HP:0100723)2.23813528
144Severe combined immunodeficiency (HP:0004430)2.20517813
145Chronic sinusitis (HP:0011109)2.18680428
146Chronic otitis media (HP:0000389)2.18187551
147Decreased circulating renin level (HP:0003351)2.18043816
148Personality changes (HP:0000751)2.17693461
149Microretrognathia (HP:0000308)2.17585918
150Lethargy (HP:0001254)2.17309082
151Death in infancy (HP:0001522)2.16112682
152CNS demyelination (HP:0007305)2.15750478
153Petechiae (HP:0000967)2.15367782
154Bundle branch block (HP:0011710)2.14330165
155Osteomyelitis (HP:0002754)2.12673628
156Abnormal spermatogenesis (HP:0008669)2.11764874
157Abnormality of the pericardium (HP:0001697)2.11440451
158Meckel diverticulum (HP:0002245)2.10576095
159Restrictive lung disease (HP:0002091)2.09601962
160Methylmalonic acidemia (HP:0002912)2.08871506
161Hypochromic microcytic anemia (HP:0004840)2.06277151
162Peritonitis (HP:0002586)2.06236589
163Microcytic anemia (HP:0001935)2.05496672
164Macrocytic anemia (HP:0001972)2.02804481
165Papilloma (HP:0012740)2.01492501
166Verrucae (HP:0200043)2.01492501
167Short clavicles (HP:0000894)2.01138095
168Unsteady gait (HP:0002317)2.00682302
169Male infertility (HP:0003251)2.00585819
170Testicular atrophy (HP:0000029)2.00333176
171Horseshoe kidney (HP:0000085)2.00287819
172Hypolipoproteinemia (HP:0010981)1.99726693
173Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99507833
174Stomach cancer (HP:0012126)1.99292902
175Athetosis (HP:0002305)1.98149676
176Keratitis (HP:0000491)1.96605608
177Aplasia/Hypoplasia of the earlobes (HP:0009906)1.95822947
178Polyneuropathy (HP:0001271)1.95585839
179Increased circulating renin level (HP:0000848)1.94369171
180Hepatic necrosis (HP:0002605)1.93221990
181Recurrent sinusitis (HP:0011108)1.93146833
182IgM deficiency (HP:0002850)1.92879817
183Fused cervical vertebrae (HP:0002949)1.92516501
184Emphysema (HP:0002097)1.92437438
185Viral hepatitis (HP:0006562)1.91883772
186Hypoglycemic coma (HP:0001325)1.91792218
187Skin rash (HP:0000988)1.91692504
188Sepsis (HP:0100806)1.91290903
189Fibular aplasia (HP:0002990)1.91020881
190Neoplasm of the tracheobronchial system (HP:0100552)1.89916527
191Breast aplasia (HP:0100783)1.89658668
192Stenosis of the external auditory canal (HP:0000402)1.88085186
193Neoplasm of the pancreas (HP:0002894)1.87976433
194Malnutrition (HP:0004395)1.87466482
195Aplasia/hypoplasia of the uterus (HP:0008684)1.86763842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.32389636
2EPHA24.83809666
3WEE14.64705347
4RIPK43.66978131
5MAP4K13.59268474
6PLK43.44860332
7STK163.39868929
8BLK3.39758408
9PNCK3.31768682
10EIF2AK13.17753012
11IRAK33.16491627
12TXK3.05776834
13TTK2.98073957
14TAOK32.92751600
15NME12.88741105
16ZAK2.78759005
17TYK22.63301645
18NEK12.31737378
19IKBKE2.26382883
20MARK12.23164190
21MAP3K142.21823152
22AKT32.15117007
23TSSK62.11511400
24JAK32.08509056
25CSK2.07093964
26SYK2.03713126
27ZAP702.00749600
28FES1.97872841
29BTK1.95270370
30ARAF1.88897532
31JAK11.87046685
32ERN11.84634770
33SRPK11.84150850
34KIT1.83410761
35NUAK11.76232279
36MAP2K31.75414161
37BRAF1.71705465
38IKBKB1.69255524
39TNK21.67005417
40TEC1.66134708
41EIF2AK31.65387934
42TBK11.59434397
43BMPR21.56988636
44RPS6KB21.51516484
45BRSK21.50925093
46HCK1.50275359
47LYN1.49729926
48MAP3K131.47149148
49ITK1.47002169
50PRKCI1.42256222
51PIK3CG1.38947484
52PLK31.35102933
53LCK1.34309885
54PLK11.33977083
55NEK21.25275697
56CSF1R1.24644386
57PDK31.21562021
58PDK41.21562021
59MARK31.18752088
60MAP3K111.15111110
61JAK21.14482410
62CHEK21.12969957
63TESK21.11573433
64FGFR31.11025279
65LATS21.10966877
66ADRBK21.10961935
67TGFBR21.09193960
68MAP3K31.09193882
69PRPF4B1.07970096
70PDK21.07362439
71NEK91.06789570
72STK241.04522118
73STK38L1.03893504
74FGR1.03440523
75LATS11.00737484
76MAP3K81.00631432
77CAMKK21.00319811
78AURKA1.00258859
79EPHB11.00066144
80IRAK41.00004161
81MATK0.99168991
82BRSK10.97396417
83MST40.96082857
84EPHA40.94158588
85GRK70.93523017
86FRK0.93334879
87PBK0.93206054
88ABL20.92499688
89IRAK20.90855268
90PTK2B0.90622897
91MST1R0.90557067
92CHUK0.90078162
93MAP3K10.86341098
94HIPK20.86335574
95PRKCQ0.86258666
96PIM20.84738329
97AURKB0.83707399
98CDC42BPA0.81398773
99PRKD20.78060702
100TRPM70.77570230
101STK100.75802569
102EPHA30.75743342
103MAP2K20.75592535
104CAMK2B0.72830654
105GRK10.71182134
106MAPK70.71090906
107SIK20.69369582
108PAK40.69258764
109PAK10.68346713
110MAP3K70.67991947
111PDK10.67102851
112MAP3K20.65677177
113IRAK10.64892703
114FGFR40.64298145
115MKNK20.64044760
116TLK10.62962659
117TAOK20.58633987
118MAPK110.56999348
119CAMK2G0.56253891
120DYRK30.55583918
121SGK20.55574548
122ABL10.55191385
123CSNK1G20.52612274
124EIF2AK20.51687884
125SIK30.51534301
126MAPK120.51483257
127PLK20.48830183
128MOS0.48183741
129TAOK10.47752325
130MAP2K10.46208058
131CHEK10.44891974
132NME20.44511497
133WNK10.43885215
134DYRK20.43850797
135PDPK10.42921038
136CAMK2D0.42211990
137STK30.41756025
138SGK30.41422166
139ACVR1B0.41415387
140CDK40.40773809
141FYN0.40053143
142STK40.39852566
143MKNK10.39707604
144MAPKAPK20.39210442
145YES10.39162498
146ADRBK10.39138315
147CSNK1E0.38867741
148VRK10.38657029
149CSNK2A10.38016450
150ATR0.36780927
151KDR0.36706106
152RPS6KA60.36600647
153CDK20.35404918
154CDC70.34342535
155STK110.33536791
156PDGFRB0.33159824
157MAP3K90.32997611
158ALK0.32739230
159LRRK20.32594055
160OXSR10.32118198
161RAF10.30797531
162NLK0.30583610
163GRK50.29564058
164MARK20.29179570
165CCNB10.27607194
166MAPK30.26898904
167SCYL20.26535672
168CSNK1A10.25680267
169MAP3K50.25671271
170MELK0.24454550
171CSNK2A20.23969140
172PRKCG0.20876938
173PRKAA20.20794810
174CDK10.19999439
175GRK60.17253697
176ILK0.16025176
177MAP2K60.15761930
178CDK70.14174450
179TESK10.14080477
180MAP3K60.11913819
181PIM10.11469822
182STK380.10586110

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.78911099
2Graft-versus-host disease_Homo sapiens_hsa053323.31364462
3Allograft rejection_Homo sapiens_hsa053303.31131170
4RNA polymerase_Homo sapiens_hsa030203.24541352
5Autoimmune thyroid disease_Homo sapiens_hsa053203.12049194
6Staphylococcus aureus infection_Homo sapiens_hsa051502.95831696
7Asthma_Homo sapiens_hsa053102.91598681
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87932389
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.86676174
10Leishmaniasis_Homo sapiens_hsa051402.82298836
11Primary immunodeficiency_Homo sapiens_hsa053402.77043028
12Vitamin B6 metabolism_Homo sapiens_hsa007502.75563345
13Fructose and mannose metabolism_Homo sapiens_hsa000512.74357841
14Fat digestion and absorption_Homo sapiens_hsa049752.68620512
15Pentose phosphate pathway_Homo sapiens_hsa000302.67476899
16RNA transport_Homo sapiens_hsa030132.55401753
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54330238
18Type I diabetes mellitus_Homo sapiens_hsa049402.48356796
19Regulation of autophagy_Homo sapiens_hsa041402.41877681
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.41266128
21Osteoclast differentiation_Homo sapiens_hsa043802.29866589
22DNA replication_Homo sapiens_hsa030302.22739688
23Mismatch repair_Homo sapiens_hsa034302.14174762
24Pyrimidine metabolism_Homo sapiens_hsa002402.13257099
25Antigen processing and presentation_Homo sapiens_hsa046122.06523366
26B cell receptor signaling pathway_Homo sapiens_hsa046622.03538675
27NF-kappa B signaling pathway_Homo sapiens_hsa040642.00886968
28Vitamin digestion and absorption_Homo sapiens_hsa049771.99101717
29Hematopoietic cell lineage_Homo sapiens_hsa046401.95673630
30Folate biosynthesis_Homo sapiens_hsa007901.93783709
31Tuberculosis_Homo sapiens_hsa051521.90361125
32Renin-angiotensin system_Homo sapiens_hsa046141.85113456
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82686996
34Viral myocarditis_Homo sapiens_hsa054161.79312646
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.76844061
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75806484
37Glutathione metabolism_Homo sapiens_hsa004801.74356044
38Ribosome_Homo sapiens_hsa030101.74312779
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74071501
40Spliceosome_Homo sapiens_hsa030401.69462887
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67940273
42Toxoplasmosis_Homo sapiens_hsa051451.67095040
43Measles_Homo sapiens_hsa051621.65763392
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64588959
45Cell cycle_Homo sapiens_hsa041101.61700219
46Influenza A_Homo sapiens_hsa051641.61325250
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61055617
48Homologous recombination_Homo sapiens_hsa034401.60670557
49Galactose metabolism_Homo sapiens_hsa000521.60072161
50T cell receptor signaling pathway_Homo sapiens_hsa046601.57338294
51Rheumatoid arthritis_Homo sapiens_hsa053231.50614040
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.47833812
53Linoleic acid metabolism_Homo sapiens_hsa005911.47137408
54Malaria_Homo sapiens_hsa051441.47100457
55Base excision repair_Homo sapiens_hsa034101.46403983
56Arachidonic acid metabolism_Homo sapiens_hsa005901.45941440
57Mineral absorption_Homo sapiens_hsa049781.44754899
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.43285738
59Herpes simplex infection_Homo sapiens_hsa051681.40848156
60Purine metabolism_Homo sapiens_hsa002301.40145243
61Nucleotide excision repair_Homo sapiens_hsa034201.39397663
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38502545
63Glycerophospholipid metabolism_Homo sapiens_hsa005641.36194272
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35548300
65Basal transcription factors_Homo sapiens_hsa030221.31330285
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30772811
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30744519
68TNF signaling pathway_Homo sapiens_hsa046681.29819281
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29583087
70Drug metabolism - other enzymes_Homo sapiens_hsa009831.25846423
71Fanconi anemia pathway_Homo sapiens_hsa034601.25566312
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23727623
73Carbon metabolism_Homo sapiens_hsa012001.20733216
74Chemokine signaling pathway_Homo sapiens_hsa040621.20292618
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.19694726
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18913057
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16687931
78Legionellosis_Homo sapiens_hsa051341.16348272
79Other glycan degradation_Homo sapiens_hsa005111.13487685
80Epstein-Barr virus infection_Homo sapiens_hsa051691.10463836
81African trypanosomiasis_Homo sapiens_hsa051431.06140723
82Acute myeloid leukemia_Homo sapiens_hsa052211.04693597
83Platelet activation_Homo sapiens_hsa046111.03661849
84Caffeine metabolism_Homo sapiens_hsa002321.02402198
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00595069
86p53 signaling pathway_Homo sapiens_hsa041151.00481807
87Hepatitis C_Homo sapiens_hsa051600.99740226
88Phagosome_Homo sapiens_hsa041450.99692813
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98599766
90Pertussis_Homo sapiens_hsa051330.98511984
91Dorso-ventral axis formation_Homo sapiens_hsa043200.97075423
92Hepatitis B_Homo sapiens_hsa051610.96352630
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92446909
94Oocyte meiosis_Homo sapiens_hsa041140.88220561
95Sphingolipid metabolism_Homo sapiens_hsa006000.87586241
96Systemic lupus erythematosus_Homo sapiens_hsa053220.87267875
97Selenocompound metabolism_Homo sapiens_hsa004500.85460282
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85442336
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84382207
100Non-small cell lung cancer_Homo sapiens_hsa052230.80363106
101One carbon pool by folate_Homo sapiens_hsa006700.79923548
102Arginine and proline metabolism_Homo sapiens_hsa003300.79457049
103Huntingtons disease_Homo sapiens_hsa050160.75749831
104RNA degradation_Homo sapiens_hsa030180.74108818
105Biosynthesis of amino acids_Homo sapiens_hsa012300.74019935
106Apoptosis_Homo sapiens_hsa042100.71815466
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.70268369
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69319875
109Pancreatic cancer_Homo sapiens_hsa052120.66949876
110Prolactin signaling pathway_Homo sapiens_hsa049170.66281781
111Metabolic pathways_Homo sapiens_hsa011000.65824728
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65113188
113Circadian rhythm_Homo sapiens_hsa047100.64579299
114Glycerolipid metabolism_Homo sapiens_hsa005610.61522627
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61263469
116VEGF signaling pathway_Homo sapiens_hsa043700.59715859
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59085200
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58572330
119Ether lipid metabolism_Homo sapiens_hsa005650.58456659
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53159876
121FoxO signaling pathway_Homo sapiens_hsa040680.52599689
122Oxidative phosphorylation_Homo sapiens_hsa001900.52552161
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52175831
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.52087608
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51397165
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48293523
127beta-Alanine metabolism_Homo sapiens_hsa004100.47932953
128Viral carcinogenesis_Homo sapiens_hsa052030.47495187
129HTLV-I infection_Homo sapiens_hsa051660.47434651
130Complement and coagulation cascades_Homo sapiens_hsa046100.47100089
131Shigellosis_Homo sapiens_hsa051310.46132713
132Salmonella infection_Homo sapiens_hsa051320.46013805
133Insulin resistance_Homo sapiens_hsa049310.45827868
134Parkinsons disease_Homo sapiens_hsa050120.44104126
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43470355
136PPAR signaling pathway_Homo sapiens_hsa033200.41854625
137Histidine metabolism_Homo sapiens_hsa003400.41306175
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.41194980
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40299401
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.39951233
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.39483549
142ABC transporters_Homo sapiens_hsa020100.39227981
143Type II diabetes mellitus_Homo sapiens_hsa049300.38850944
144Renal cell carcinoma_Homo sapiens_hsa052110.38550086
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37954617
146Retinol metabolism_Homo sapiens_hsa008300.37527712
147Starch and sucrose metabolism_Homo sapiens_hsa005000.37247535
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36466470
149Non-homologous end-joining_Homo sapiens_hsa034500.36346640
150mTOR signaling pathway_Homo sapiens_hsa041500.36070718
151Chronic myeloid leukemia_Homo sapiens_hsa052200.36065986
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34898771
153Tight junction_Homo sapiens_hsa045300.34755938
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.34522463
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.34370415
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34025052
157Choline metabolism in cancer_Homo sapiens_hsa052310.32545427
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32153576
159MAPK signaling pathway_Homo sapiens_hsa040100.31503625
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30500314
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28069798
162Prostate cancer_Homo sapiens_hsa052150.26873199
163Arginine biosynthesis_Homo sapiens_hsa002200.26581864
164Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25846662
165Endocytosis_Homo sapiens_hsa041440.25537586
166Inositol phosphate metabolism_Homo sapiens_hsa005620.24663185
167Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23736846
168Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22940246
169Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22788775
170Amoebiasis_Homo sapiens_hsa051460.22781350
171mRNA surveillance pathway_Homo sapiens_hsa030150.22668145
172HIF-1 signaling pathway_Homo sapiens_hsa040660.21640837
173Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21427943
174Protein digestion and absorption_Homo sapiens_hsa049740.19089811
175Collecting duct acid secretion_Homo sapiens_hsa049660.18954318
176Pyruvate metabolism_Homo sapiens_hsa006200.18191007
177Bile secretion_Homo sapiens_hsa049760.15093988
178Sulfur metabolism_Homo sapiens_hsa009200.11384610
179Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10448219
180Vibrio cholerae infection_Homo sapiens_hsa051100.10285061
181Protein export_Homo sapiens_hsa030600.09849566
182Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.09176080
183Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.07653602
184Propanoate metabolism_Homo sapiens_hsa006400.07275826
185Butanoate metabolism_Homo sapiens_hsa006500.07088779
186Peroxisome_Homo sapiens_hsa041460.05941339
187Fatty acid degradation_Homo sapiens_hsa000710.04153110
188Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04032839
189Lysosome_Homo sapiens_hsa041420.03637006

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