TRIM39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation, ncRNA-mediated (GO:0040033)5.18545471
2regulation of translation, ncRNA-mediated (GO:0045974)5.18545471
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.18545471
4positive regulation of gamma-delta T cell activation (GO:0046645)4.71606024
5negative regulation of inclusion body assembly (GO:0090084)4.62191054
6regulation of gamma-delta T cell differentiation (GO:0045586)4.47518180
7histone H3-K4 trimethylation (GO:0080182)4.37755340
8regulation of helicase activity (GO:0051095)4.34395765
9negative regulation of erythrocyte differentiation (GO:0045647)4.33182511
10regulation of gamma-delta T cell activation (GO:0046643)4.32345027
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.28467551
12protein localization to microtubule (GO:0035372)4.23358298
13positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.13677455
143-UTR-mediated mRNA stabilization (GO:0070935)4.10919834
15prepulse inhibition (GO:0060134)4.09465100
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06547340
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04183529
18positive regulation of histone deacetylation (GO:0031065)4.02547501
19response to peptidoglycan (GO:0032494)3.99279243
20peptidyl-lysine trimethylation (GO:0018023)3.96312621
21antigen processing and presentation of endogenous antigen (GO:0019883)3.95873268
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88895825
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.88895825
24modulation by symbiont of host immune response (GO:0052553)3.88895825
25positive regulation by symbiont of host defense response (GO:0052509)3.88895825
26modulation by symbiont of host defense response (GO:0052031)3.88895825
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88895825
28cilium or flagellum-dependent cell motility (GO:0001539)3.83168184
29regulation of B cell receptor signaling pathway (GO:0050855)3.80763492
30pre-miRNA processing (GO:0031054)3.77859901
31regulation of histone H3-K27 methylation (GO:0061085)3.73750677
32regulation of cilium movement (GO:0003352)3.65703291
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64966302
34positive T cell selection (GO:0043368)3.58577918
35peptidyl-lysine dimethylation (GO:0018027)3.53672006
36negative regulation of cell killing (GO:0031342)3.53480431
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53480431
38detection of other organism (GO:0098543)3.53374094
39response to muramyl dipeptide (GO:0032495)3.47619087
40response to interleukin-15 (GO:0070672)3.45262105
41peptidyl-lysine methylation (GO:0018022)3.44620647
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.44369771
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42049816
44protein targeting to Golgi (GO:0000042)3.40573913
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.39224341
46megakaryocyte development (GO:0035855)3.34578805
47tolerance induction (GO:0002507)3.34335417
48establishment of protein localization to Golgi (GO:0072600)3.32835472
49detection of bacterium (GO:0016045)3.30928819
50negative regulation of interleukin-12 production (GO:0032695)3.28614533
51negative regulation of T cell receptor signaling pathway (GO:0050860)3.28572193
52T cell selection (GO:0045058)3.25352975
53neutrophil activation involved in immune response (GO:0002283)3.24930877
54negative regulation of Ras GTPase activity (GO:0034261)3.18094749
55positive regulation of CREB transcription factor activity (GO:0032793)3.15810414
56leukocyte aggregation (GO:0070486)3.14646924
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.12680907
58histone H3-K4 methylation (GO:0051568)3.11210333
59macrophage activation involved in immune response (GO:0002281)3.10174897
60histone H4-K16 acetylation (GO:0043984)3.09110188
61germinal center formation (GO:0002467)3.08147129
62positive thymic T cell selection (GO:0045059)3.08105640
63negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.07540039
64mRNA splice site selection (GO:0006376)3.05426487
65negative regulation of DNA recombination (GO:0045910)3.05325086
66negative T cell selection (GO:0043383)3.04335034
67B cell receptor signaling pathway (GO:0050853)3.00620580
68detection of molecule of bacterial origin (GO:0032490)3.00020091
69detection of external biotic stimulus (GO:0098581)2.98959482
70axonemal dynein complex assembly (GO:0070286)2.97520989
71sperm motility (GO:0030317)2.97491841
72cellular response to interleukin-15 (GO:0071350)2.97311080
73locomotory exploration behavior (GO:0035641)2.96807276
74histone H2A acetylation (GO:0043968)2.96145786
75respiratory burst (GO:0045730)2.95844879
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95651979
77modulation by virus of host process (GO:0019054)2.95457448
78histone lysine methylation (GO:0034968)2.94528203
79regulation of histone deacetylation (GO:0031063)2.93761727
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92861642
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92861642
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.92861642
83negative regulation of leukocyte mediated immunity (GO:0002704)2.92656161
84negative regulation of osteoblast proliferation (GO:0033689)2.92619032
85histone H4-K5 acetylation (GO:0043981)2.89025987
86histone H4-K8 acetylation (GO:0043982)2.89025987
87regulation of interferon-beta biosynthetic process (GO:0045357)2.88873379
88pericardium development (GO:0060039)2.88320334
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.87429026
90relaxation of smooth muscle (GO:0044557)2.87337258
91negative regulation of T cell mediated immunity (GO:0002710)2.87087515
92motile cilium assembly (GO:0044458)2.86873837
93negative regulation of histone methylation (GO:0031061)2.86357644
94negative thymic T cell selection (GO:0045060)2.84575180
95acrosome reaction (GO:0007340)2.84295549
96regulation of regulatory T cell differentiation (GO:0045589)2.83844686
97thymic T cell selection (GO:0045061)2.83478053
98embryonic hemopoiesis (GO:0035162)2.82404172
99negative regulation of innate immune response (GO:0045824)2.80204381
100histone H4-K12 acetylation (GO:0043983)2.77111331
101negative regulation of homotypic cell-cell adhesion (GO:0034111)2.76110555
102oligosaccharide catabolic process (GO:0009313)2.74415675
103NIK/NF-kappaB signaling (GO:0038061)2.74182900
104regulation of ARF protein signal transduction (GO:0032012)2.74160246
105histone H3-K9 modification (GO:0061647)2.70960551
106regulation of histone methylation (GO:0031060)2.70911905
107cerebellar Purkinje cell differentiation (GO:0021702)2.69542345
108positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.69523324
109regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.69523324
110definitive hemopoiesis (GO:0060216)2.69038338
111cellular extravasation (GO:0045123)2.68829298
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68775947
113detection of biotic stimulus (GO:0009595)2.67063253
114neutrophil activation (GO:0042119)2.63202564
115positive regulation of granulocyte differentiation (GO:0030854)2.63120045
116positive regulation of mRNA metabolic process (GO:1903313)2.63006071
117histone H3-K36 demethylation (GO:0070544)2.62385720
118negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.62173897
119calcium ion-dependent exocytosis (GO:0017156)2.61089621
120lactate metabolic process (GO:0006089)2.60579883
121regulation of RNA export from nucleus (GO:0046831)2.60338036
122response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59594394
123response to host immune response (GO:0052572)2.59594394
124regulation of amyloid precursor protein catabolic process (GO:1902991)2.59199982
125regulation of B cell differentiation (GO:0045577)2.59120072
126regulation of mast cell degranulation (GO:0043304)2.58415284
127stress granule assembly (GO:0034063)2.58219913
128positive regulation of mRNA processing (GO:0050685)2.58217618
129histone H4 acetylation (GO:0043967)2.57760160
130immunoglobulin mediated immune response (GO:0016064)2.57520094
131regulation of tolerance induction (GO:0002643)2.55137867
132monoubiquitinated protein deubiquitination (GO:0035520)2.54678788
133regulation of T cell receptor signaling pathway (GO:0050856)2.53574773
134regulation of platelet aggregation (GO:0090330)2.52857072
135regulation of mononuclear cell migration (GO:0071675)2.52157452
136histone H3-K9 methylation (GO:0051567)2.52043762
137regulation of leukocyte degranulation (GO:0043300)2.51504665
138response to host (GO:0075136)2.51424962
139response to host defenses (GO:0052200)2.51424962
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51424962
141defense response to protozoan (GO:0042832)2.50503133
142granulocyte activation (GO:0036230)2.50223714
143positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50207376
144positive regulation of protein deacetylation (GO:0090312)2.49462199
145lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49397237
146epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49201749
147positive regulation of mRNA catabolic process (GO:0061014)2.48600115
148positive regulation of tolerance induction (GO:0002645)2.48019528
149regulation of necroptotic process (GO:0060544)2.47823726
150CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47260255
151mitotic sister chromatid cohesion (GO:0007064)2.47113425
152spermatid development (GO:0007286)2.45394987
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44510509
154regulation of transforming growth factor beta2 production (GO:0032909)2.44445607
155intra-Golgi vesicle-mediated transport (GO:0006891)2.44092284
156positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43449500
157protein localization to microtubule cytoskeleton (GO:0072698)2.42922411
158histone mRNA catabolic process (GO:0071044)2.42745577
159histone H3-K9 demethylation (GO:0033169)2.42348529
160positive regulation of B cell differentiation (GO:0045579)2.42236365
161adaptation of signaling pathway (GO:0023058)2.41884036
162poly(A)+ mRNA export from nucleus (GO:0016973)2.41705667
163regulation of cellular amide metabolic process (GO:0034248)2.40879843
164interferon-gamma production (GO:0032609)2.40655065
165regulation of mRNA catabolic process (GO:0061013)2.40339039
166type I interferon signaling pathway (GO:0060337)2.40161003
167cellular response to type I interferon (GO:0071357)2.40161003
168T cell homeostasis (GO:0043029)2.39917670
169regulation of T cell tolerance induction (GO:0002664)2.39388997
170regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38516165
171histone lysine demethylation (GO:0070076)2.38511633
172response to type I interferon (GO:0034340)2.38438234
173negative regulation of necroptotic process (GO:0060546)2.38082413
174response to protozoan (GO:0001562)2.38051469
175nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.37875336
176positive regulation of RNA splicing (GO:0033120)2.37777077
177histone demethylation (GO:0016577)2.37640899
178vesicle fusion (GO:0006906)2.37341938
179protein localization to Golgi apparatus (GO:0034067)2.34784401
180glycosphingolipid catabolic process (GO:0046479)2.34715309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.99269955
2EZH2_22144423_ChIP-Seq_EOC_Human3.53813237
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37243816
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24424396
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.20364943
6GATA1_22025678_ChIP-Seq_K562_Human3.14336117
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.09272951
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98908800
9MYC_22102868_ChIP-Seq_BL_Human2.83707997
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.63577868
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53087110
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49760070
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48916026
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38004390
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33284628
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19736177
17RUNX_20019798_ChIP-Seq_JUKART_Human2.15459176
18SPI1_23547873_ChIP-Seq_NB4_Human2.09791789
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.07555643
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03553791
21TCF7_22412390_ChIP-Seq_EML_Mouse2.03130796
22* NOTCH1_21737748_ChIP-Seq_TLL_Human2.02538178
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01585993
24* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01431747
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00430243
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99375936
27* RUNX1_22412390_ChIP-Seq_EML_Mouse1.98085543
28DROSHA_22980978_ChIP-Seq_HELA_Human1.96996233
29VDR_24763502_ChIP-Seq_THP-1_Human1.95521736
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92770954
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.89731185
32SCL_19346495_ChIP-Seq_HPC-7_Human1.86764814
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84003021
34MAF_26560356_Chip-Seq_TH2_Human1.83562633
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80371059
36CIITA_25753668_ChIP-Seq_RAJI_Human1.73728210
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.70140926
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69222422
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67507160
40SPI1_23127762_ChIP-Seq_K562_Human1.67178095
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65871971
42REST_21632747_ChIP-Seq_MESCs_Mouse1.63563321
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.63414586
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63056641
45TFEB_21752829_ChIP-Seq_HELA_Human1.62411981
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.59749105
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.57053234
48IGF1R_20145208_ChIP-Seq_DFB_Human1.56230470
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55397271
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53404724
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.53369750
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53356543
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.51277021
54UTX_26944678_Chip-Seq_JUKART_Human1.51239572
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48577941
56MYB_26560356_Chip-Seq_TH2_Human1.46155019
57MYB_26560356_Chip-Seq_TH1_Human1.44494322
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43900258
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42308396
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41981748
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41720115
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41470662
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40030842
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39669088
65* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36994476
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35729517
67KDM2B_26808549_Chip-Seq_DND41_Human1.35172460
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32318038
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32045959
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30766684
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30250399
72NCOR1_26117541_ChIP-Seq_K562_Human1.29569820
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28311785
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28311785
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28154890
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27502277
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.27462439
78PU_27001747_Chip-Seq_BMDM_Mouse1.25995969
79E2F7_22180533_ChIP-Seq_HELA_Human1.25507682
80RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24449502
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24241823
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19886751
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19167478
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.19128611
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18854000
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18703291
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18579237
88STAT3_23295773_ChIP-Seq_U87_Human1.17460131
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14703962
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14573298
91RNF2_27304074_Chip-Seq_NSC_Mouse1.12834712
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12259582
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.11449990
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11287642
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09655203
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09485744
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.08141808
98AR_19668381_ChIP-Seq_PC3_Human1.07628035
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06837261
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06576370
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06263968
102GATA1_19941826_ChIP-Seq_K562_Human1.06070482
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05842612
104RACK7_27058665_Chip-Seq_MCF-7_Human1.05529772
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04961001
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.04297724
107TCF4_23295773_ChIP-Seq_U87_Human1.04178599
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04086159
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04072793
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03998541
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03607589
112MAF_26560356_Chip-Seq_TH1_Human1.03305081
113FOXM1_23109430_ChIP-Seq_U2OS_Human1.03014367
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.02349752
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01059497
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00962516
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00615125
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.00554412
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99975492
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99960220
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99833004
122DCP1A_22483619_ChIP-Seq_HELA_Human0.99404864
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99070189
124* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98744345
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96789382
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95199820
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95096037
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95096037
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95096037
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94617872
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94528453
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.94370845
133HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94280166
134* VDR_23849224_ChIP-Seq_CD4+_Human0.92402539
135ATF3_27146783_Chip-Seq_COLON_Human0.92197311
136LXR_22292898_ChIP-Seq_THP-1_Human0.92085356
137CLOCK_20551151_ChIP-Seq_293T_Human0.91793044
138CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91696956
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91157042
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90901937
141REST_18959480_ChIP-ChIP_MESCs_Mouse0.89690540
142FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89504802
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88777443
144SMAD4_21799915_ChIP-Seq_A2780_Human0.85361706
145GATA3_26560356_Chip-Seq_TH1_Human0.83010445
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82956987
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82706102
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.82330108
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80920021
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79624155
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79043402
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78988299
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78187659
154GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77999084
155PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77768088
156EZH2_27294783_Chip-Seq_ESCs_Mouse0.77679485
157* RUNX2_22187159_ChIP-Seq_PCA_Human0.77369729
158FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77213265
159RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77152346
160TBX3_20139965_ChIP-Seq_MESCs_Mouse0.77070591
161VDR_21846776_ChIP-Seq_THP-1_Human0.76978443
162SUZ12_27294783_Chip-Seq_ESCs_Mouse0.76737951
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.75805811
164TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75782571
165TAF15_26573619_Chip-Seq_HEK293_Human0.74427971
166NFE2_27457419_Chip-Seq_LIVER_Mouse0.74382032
167WDR5_24793694_ChIP-Seq_LNCAP_Human0.74217952
168ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73253821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.90068175
2MP0003763_abnormal_thymus_physiology3.76757392
3MP0003436_decreased_susceptibility_to3.29413911
4MP0003787_abnormal_imprinting3.20619334
5MP0003183_abnormal_peptide_metabolism3.08146366
6MP0001873_stomach_inflammation2.62830647
7MP0006082_CNS_inflammation2.56123926
8MP0005410_abnormal_fertilization2.53326737
9MP0002877_abnormal_melanocyte_morpholog2.53070844
10MP0008260_abnormal_autophagy2.48037111
11MP0003724_increased_susceptibility_to2.45655149
12MP0005451_abnormal_body_composition2.45443600
13MP0009780_abnormal_chondrocyte_physiolo2.27284748
14MP0005000_abnormal_immune_tolerance2.24597384
15MP0002419_abnormal_innate_immunity2.24488976
16MP0005076_abnormal_cell_differentiation2.22961869
17MP0005025_abnormal_response_to2.13591714
18MP0003191_abnormal_cellular_cholesterol2.07073265
19MP0005423_abnormal_somatic_nervous2.03755842
20MP0000569_abnormal_digit_pigmentation2.02537984
21MP0009333_abnormal_splenocyte_physiolog1.98980562
22MP0009697_abnormal_copulation1.98515846
23MP0002405_respiratory_system_inflammati1.93640400
24MP0008569_lethality_at_weaning1.92369488
25MP0008961_abnormal_basal_metabolism1.92036430
26MP0005670_abnormal_white_adipose1.91858406
27MP0002009_preneoplasia1.91653660
28MP0005645_abnormal_hypothalamus_physiol1.90224267
29MP0005174_abnormal_tail_pigmentation1.89602687
30MP0005397_hematopoietic_system_phenotyp1.88786831
31MP0001545_abnormal_hematopoietic_system1.88786831
32MP0000858_altered_metastatic_potential1.88613152
33MP0009785_altered_susceptibility_to1.88120714
34MP0004947_skin_inflammation1.79660123
35MP0002928_abnormal_bile_duct1.78353858
36MP0009278_abnormal_bone_marrow1.75914683
37MP0002396_abnormal_hematopoietic_system1.70854140
38MP0008995_early_reproductive_senescence1.68254345
39MP0003828_pulmonary_edema1.67775924
40MP0000015_abnormal_ear_pigmentation1.67677326
41MP0002398_abnormal_bone_marrow1.66969804
42MP0004264_abnormal_extraembryonic_tissu1.66853382
43MP0005310_abnormal_salivary_gland1.61693229
44MP0000685_abnormal_immune_system1.61653469
45MP0002148_abnormal_hypersensitivity_rea1.59158313
46MP0003698_abnormal_male_reproductive1.57336503
47MP0002132_abnormal_respiratory_system1.56535183
48MP0003453_abnormal_keratinocyte_physiol1.55446694
49MP0003635_abnormal_synaptic_transmissio1.52948040
50MP0001800_abnormal_humoral_immune1.51714857
51MP0000703_abnormal_thymus_morphology1.51305237
52MP0001486_abnormal_startle_reflex1.49796880
53MP0001929_abnormal_gametogenesis1.49189255
54MP0003943_abnormal_hepatobiliary_system1.48892558
55MP0008057_abnormal_DNA_replication1.48868050
56MP0004808_abnormal_hematopoietic_stem1.46768457
57MP0003121_genomic_imprinting1.46672052
58MP0005075_abnormal_melanosome_morpholog1.46650620
59MP0001533_abnormal_skeleton_physiology1.46151926
60MP0005671_abnormal_response_to1.45058882
61MP0005379_endocrine/exocrine_gland_phen1.43042796
62MP0003656_abnormal_erythrocyte_physiolo1.42749787
63MP0009046_muscle_twitch1.41448607
64MP0001944_abnormal_pancreas_morphology1.38589363
65MP0005387_immune_system_phenotype1.38163598
66MP0001790_abnormal_immune_system1.38163598
67MP0002693_abnormal_pancreas_physiology1.37038406
68MP0001845_abnormal_inflammatory_respons1.35774148
69MP0003868_abnormal_feces_composition1.32741570
70MP0002166_altered_tumor_susceptibility1.29867487
71MP0000490_abnormal_crypts_of1.29524441
72MP0001502_abnormal_circadian_rhythm1.29411554
73MP0010234_abnormal_vibrissa_follicle1.28470243
74MP0004859_abnormal_synaptic_plasticity1.28175612
75MP0009840_abnormal_foam_cell1.27808787
76MP0001270_distended_abdomen1.27799775
77MP0005464_abnormal_platelet_physiology1.26089114
78MP0008877_abnormal_DNA_methylation1.25055148
79MP0010386_abnormal_urinary_bladder1.25023653
80MP0006072_abnormal_retinal_apoptosis1.23956187
81MP0002095_abnormal_skin_pigmentation1.23734891
82MP0001986_abnormal_taste_sensitivity1.22375146
83MP0001853_heart_inflammation1.22321195
84MP0004885_abnormal_endolymph1.21749042
85MP0003693_abnormal_embryo_hatching1.21271700
86MP0002019_abnormal_tumor_incidence1.19673347
87MP0002420_abnormal_adaptive_immunity1.19411761
88MP0000716_abnormal_immune_system1.17781920
89MP0002557_abnormal_social/conspecific_i1.17458598
90MP0010094_abnormal_chromosome_stability1.15989979
91MP0001915_intracranial_hemorrhage1.14823214
92MP0010155_abnormal_intestine_physiology1.13951468
93MP0001819_abnormal_immune_cell1.13713670
94MP0001440_abnormal_grooming_behavior1.13697696
95MP0002998_abnormal_bone_remodeling1.10731743
96MP0000566_synostosis1.06072235
97MP0003122_maternal_imprinting1.05183359
98MP0003300_gastrointestinal_ulcer1.04714136
99MP0002277_abnormal_respiratory_mucosa1.04336821
100MP0003448_altered_tumor_morphology1.04015884
101MP0002723_abnormal_immune_serum1.03181781
102MP0008469_abnormal_protein_level1.03151795
103MP0004381_abnormal_hair_follicle1.02678229
104MP0001984_abnormal_olfaction1.02559381
105MP0002163_abnormal_gland_morphology1.01241104
106MP0003091_abnormal_cell_migration1.01235679
107MP0002909_abnormal_adrenal_gland1.00651192
108MP0005551_abnormal_eye_electrophysiolog1.00356980
109MP0001501_abnormal_sleep_pattern0.98351409
110MP0002210_abnormal_sex_determination0.98138803
111MP0000003_abnormal_adipose_tissue0.97836657
112MP0002722_abnormal_immune_system0.97816717
113MP0003866_abnormal_defecation0.96397953
114MP0002429_abnormal_blood_cell0.95928891
115MP0003077_abnormal_cell_cycle0.95035251
116MP0002452_abnormal_antigen_presenting0.94887152
117MP0002063_abnormal_learning/memory/cond0.94684635
118MP0000689_abnormal_spleen_morphology0.94019544
119MP0010352_gastrointestinal_tract_polyps0.92840025
120MP0003111_abnormal_nucleus_morphology0.92517148
121MP0001663_abnormal_digestive_system0.92436914
122MP0005621_abnormal_cell_physiology0.91963532
123MP0009763_increased_sensitivity_to0.91827389
124MP0002161_abnormal_fertility/fecundity0.91597847
125MP0003221_abnormal_cardiomyocyte_apopto0.91438653
126MP0001851_eye_inflammation0.91249514
127MP0000465_gastrointestinal_hemorrhage0.90913544
128MP0000350_abnormal_cell_proliferation0.90469674
129MP0005166_decreased_susceptibility_to0.89079919
130MP0003115_abnormal_respiratory_system0.88798025
131MP0002572_abnormal_emotion/affect_behav0.88267375
132MP0001765_abnormal_ion_homeostasis0.87783565
133MP0001919_abnormal_reproductive_system0.87407207
134MP0000653_abnormal_sex_gland0.86954930
135MP0001664_abnormal_digestion0.86860643
136MP0004185_abnormal_adipocyte_glucose0.86835767
137MP0002067_abnormal_sensory_capabilities0.84244294
138MP0004510_myositis0.83767888
139MP0005394_taste/olfaction_phenotype0.83690370
140MP0005499_abnormal_olfactory_system0.83690370
141MP0002272_abnormal_nervous_system0.83364708
142MP0003045_fibrosis0.82161794
143MP0002796_impaired_skin_barrier0.81182697
144MP0005501_abnormal_skin_physiology0.79961775
145MP0001145_abnormal_male_reproductive0.79195568
146MP0009745_abnormal_behavioral_response0.77896584
147MP0000313_abnormal_cell_death0.76520948
148MP0001835_abnormal_antigen_presentation0.75919574
149MP0002006_tumorigenesis0.75783486
150MP0003075_altered_response_to0.75117377
151MP0008058_abnormal_DNA_repair0.74600333
152MP0009764_decreased_sensitivity_to0.73324046
153MP0004270_analgesia0.73313770
154MP0002160_abnormal_reproductive_system0.73098997
155MP0005058_abnormal_lysosome_morphology0.72877928
156MP0003705_abnormal_hypodermis_morpholog0.71277102
157MP0003566_abnormal_cell_adhesion0.70939784
158MP0005384_cellular_phenotype0.70894464
159MP0003172_abnormal_lysosome_physiology0.70790268
160MP0000631_abnormal_neuroendocrine_gland0.69299608
161MP0010307_abnormal_tumor_latency0.68857833
162MP0002152_abnormal_brain_morphology0.68802655
163MP0005390_skeleton_phenotype0.68570681
164MP0009931_abnormal_skin_appearance0.64604862
165MP0002086_abnormal_extraembryonic_tissu0.64274185
166MP0004957_abnormal_blastocyst_morpholog0.64251748

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.70630676
2Eczematoid dermatitis (HP:0000976)4.69115426
3Abnormality of the fingertips (HP:0001211)4.37746793
4Recurrent bacterial skin infections (HP:0005406)4.15646962
5Myositis (HP:0100614)4.11640653
6Recurrent abscess formation (HP:0002722)4.07513788
7Abnormality of macrophages (HP:0004311)4.00515149
8Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.96731547
9Retrobulbar optic neuritis (HP:0100654)3.92153675
10Optic neuritis (HP:0100653)3.92153675
11Orchitis (HP:0100796)3.90992736
12Progressive muscle weakness (HP:0003323)3.76144663
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.75390324
14Absent/shortened dynein arms (HP:0200106)3.75390324
15Volvulus (HP:0002580)3.73479698
16Abnormal hair whorl (HP:0010721)3.43360262
17Aortic aneurysm (HP:0004942)3.42103279
18Tented upper lip vermilion (HP:0010804)3.39921589
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.37551985
20Panhypogammaglobulinemia (HP:0003139)3.20840013
21Recurrent gram-negative bacterial infections (HP:0005420)3.12637452
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.12312379
23Abnormal respiratory motile cilium physiology (HP:0012261)3.10326333
24Mediastinal lymphadenopathy (HP:0100721)3.07070098
25Arterial thrombosis (HP:0004420)3.06798285
26Recurrent fungal infections (HP:0002841)2.95966027
27Severe visual impairment (HP:0001141)2.94589234
28Meningitis (HP:0001287)2.88864345
29Nasal polyposis (HP:0100582)2.88624981
30Rhinitis (HP:0012384)2.85971776
31Elevated erythrocyte sedimentation rate (HP:0003565)2.85499279
32Genetic anticipation (HP:0003743)2.84443761
33Elfin facies (HP:0004428)2.84375145
34Long foot (HP:0001833)2.83480895
35Duplicated collecting system (HP:0000081)2.81733819
36Pustule (HP:0200039)2.79035232
37Keratoconjunctivitis sicca (HP:0001097)2.73000202
38Recurrent skin infections (HP:0001581)2.72699009
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.71241244
40Renovascular hypertension (HP:0100817)2.70402502
41Abnormal ciliary motility (HP:0012262)2.67984214
42Abnormal respiratory motile cilium morphology (HP:0005938)2.62685002
43Abnormal respiratory epithelium morphology (HP:0012253)2.62685002
44Gastrointestinal infarctions (HP:0005244)2.62312800
45Inflammation of the large intestine (HP:0002037)2.61317497
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61083599
47Bronchiectasis (HP:0002110)2.58185125
48Obstructive lung disease (HP:0006536)2.58042919
49Chronic obstructive pulmonary disease (HP:0006510)2.58042919
50Increased IgE level (HP:0003212)2.57556989
51Prolonged bleeding time (HP:0003010)2.55481280
52Menstrual irregularities (HP:0000858)2.55404225
53T lymphocytopenia (HP:0005403)2.54011326
54Chronic bronchitis (HP:0004469)2.53987884
55Cellulitis (HP:0100658)2.52986048
56Chronic otitis media (HP:0000389)2.51604846
57Slow saccadic eye movements (HP:0000514)2.50803174
58Protruding tongue (HP:0010808)2.49992567
59Agammaglobulinemia (HP:0004432)2.48148406
60Gingivitis (HP:0000230)2.43972357
61Central scotoma (HP:0000603)2.43030757
62Vasculitis (HP:0002633)2.42983289
63Recurrent sinusitis (HP:0011108)2.42915502
64Gastrointestinal inflammation (HP:0004386)2.42550828
65Polyneuropathy (HP:0001271)2.42009045
66Encephalitis (HP:0002383)2.41633975
67Bronchitis (HP:0012387)2.40747229
68Chronic mucocutaneous candidiasis (HP:0002728)2.40195820
69Recurrent cutaneous fungal infections (HP:0011370)2.40195820
70Insomnia (HP:0100785)2.39167224
71Stomatitis (HP:0010280)2.38657047
72Fatigue (HP:0012378)2.37607349
73Keratoconjunctivitis (HP:0001096)2.35934135
74Acute lymphatic leukemia (HP:0006721)2.33754812
75Overriding aorta (HP:0002623)2.33353863
76Spondylolisthesis (HP:0003302)2.32917318
77Recurrent bronchitis (HP:0002837)2.31920125
78Dyschromatopsia (HP:0007641)2.25475192
79Abnormality of the renal collecting system (HP:0004742)2.24744107
80Granulocytopenia (HP:0001913)2.21406879
81Increased serum ferritin (HP:0003281)2.20248759
82Anorexia (HP:0002039)2.20232224
83Gangrene (HP:0100758)2.20126908
84Abnormality of T cell number (HP:0011839)2.19219617
85Supernumerary spleens (HP:0009799)2.17954042
86Abnormality of the intervertebral disk (HP:0005108)2.16383679
87Spontaneous hematomas (HP:0007420)2.15591906
88Progressive inability to walk (HP:0002505)2.15347581
89Rhabdomyolysis (HP:0003201)2.14777268
90Urticaria (HP:0001025)2.14603382
91Abnormality of the nasal mucosa (HP:0000433)2.14306532
92Pulmonary infiltrates (HP:0002113)2.11307851
93Loss of speech (HP:0002371)2.10988764
94Abnormality of the lower motor neuron (HP:0002366)2.09423065
95Pulmonary embolism (HP:0002204)2.08815693
96Flat cornea (HP:0007720)2.07882439
97Generalized hypopigmentation of hair (HP:0011358)2.07390170
98Infertility (HP:0000789)2.06453654
99Osteomyelitis (HP:0002754)2.06098316
100Ureteral duplication (HP:0000073)2.05328704
101Leukocytosis (HP:0001974)2.04917368
102Cystic liver disease (HP:0006706)2.01645202
103Ureteral obstruction (HP:0006000)2.01032512
104Subacute progressive viral hepatitis (HP:0006572)2.00650544
105IgG deficiency (HP:0004315)2.00594257
106Ureteral stenosis (HP:0000071)2.00571990
107Widely spaced teeth (HP:0000687)1.99023839
108Chest pain (HP:0100749)1.98976063
109Pancreatic fibrosis (HP:0100732)1.97278034
110Lymphopenia (HP:0001888)1.97078236
111Autoimmune hemolytic anemia (HP:0001890)1.96555409
112Viral hepatitis (HP:0006562)1.95018608
113Glomerulopathy (HP:0100820)1.94681976
114Intestinal atresia (HP:0011100)1.94441243
115Progressive external ophthalmoplegia (HP:0000590)1.94430624
116Skin ulcer (HP:0200042)1.94153968
117Increased IgM level (HP:0003496)1.93238077
118Recurrent otitis media (HP:0000403)1.92051278
119Neoplasm of the heart (HP:0100544)1.90817644
120Abnormality of T cell physiology (HP:0011840)1.90061715
121Chronic sinusitis (HP:0011109)1.89368225
122Abnormality of B cell number (HP:0010975)1.88241448
123B lymphocytopenia (HP:0010976)1.88241448
124Anhidrosis (HP:0000970)1.87918031
125Macroorchidism (HP:0000053)1.87805690
126Colitis (HP:0002583)1.86875956
127Acute hepatic failure (HP:0006554)1.85882335
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85539129
129Open mouth (HP:0000194)1.85085449
130Asplenia (HP:0001746)1.84660074
131Dry hair (HP:0011359)1.83728472
132Spinal cord lesions (HP:0100561)1.83448707
133Syringomyelia (HP:0003396)1.83448707
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.83332618
135Renal duplication (HP:0000075)1.81934058
136Broad palm (HP:0001169)1.79910062
137Bile duct proliferation (HP:0001408)1.79528895
138Abnormal biliary tract physiology (HP:0012439)1.79528895
139Sepsis (HP:0100806)1.79319360
140Autoamputation (HP:0001218)1.78638306
141Recurrent viral infections (HP:0004429)1.78494495
142Decreased motor nerve conduction velocity (HP:0003431)1.78112075
143Adactyly (HP:0009776)1.77561810
144Interstitial pulmonary disease (HP:0006530)1.77147973
145Menorrhagia (HP:0000132)1.76404464
146Vertebral arch anomaly (HP:0008438)1.75895218
147Abnormal foot bone ossification (HP:0010675)1.75507513
148Exotropia (HP:0000577)1.75442480
149Hypochromic anemia (HP:0001931)1.74915372
150Episodic fever (HP:0001954)1.74689640
151Epileptic encephalopathy (HP:0200134)1.74603477
152Basal cell carcinoma (HP:0002671)1.72592758
153Purpura (HP:0000979)1.72073633
154Amyotrophic lateral sclerosis (HP:0007354)1.70714141
155Hypertensive crisis (HP:0100735)1.70234093
156IgM deficiency (HP:0002850)1.70219304
157Chronic diarrhea (HP:0002028)1.69490866
158Hemoptysis (HP:0002105)1.68652592
159Verrucae (HP:0200043)1.68043913
160Limb hypertonia (HP:0002509)1.66751190
161Pancreatic islet-cell hyperplasia (HP:0004510)1.65257213
162Progressive cerebellar ataxia (HP:0002073)1.63858781
163Abnormality of the right ventricle (HP:0001707)1.63081747
164Bell-shaped thorax (HP:0001591)1.62840761
165Febrile seizures (HP:0002373)1.62442653
166Aplasia/Hypoplasia of the spleen (HP:0010451)1.61971166
167Hypoproteinemia (HP:0003075)1.59014322
168Epistaxis (HP:0000421)1.57725758
169Abnormality of ocular smooth pursuit (HP:0000617)1.57500962
170Abnormality of the diencephalon (HP:0010662)1.56869873
171Heterotopia (HP:0002282)1.55646425
172Abnormality of T cells (HP:0002843)1.55251585
173Bony spicule pigmentary retinopathy (HP:0007737)1.55022878
174Broad-based gait (HP:0002136)1.53616972
175Postaxial foot polydactyly (HP:0001830)1.53006716
176Abnormality of the intrinsic pathway (HP:0010989)1.52758364
177Oligodactyly (hands) (HP:0001180)1.52378027
178Lip pit (HP:0100267)1.52304515
179Constricted visual fields (HP:0001133)1.51147492
180Fair hair (HP:0002286)1.50402752
181Molar tooth sign on MRI (HP:0002419)1.49933417
182Abnormality of midbrain morphology (HP:0002418)1.49933417
183Absent frontal sinuses (HP:0002688)1.49658782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K34.06681350
2TAOK23.97654498
3TAOK13.96891704
4MAP3K33.83499352
5MAP4K13.07326873
6MAP3K112.65794485
7MKNK12.64250176
8CDK122.53986477
9STK242.44614716
10TXK2.37351354
11SGK32.16433936
12CDK92.09844956
13NEK62.08067066
14RIPK42.05417072
15BRD42.01982805
16STK381.99962247
17SIK21.97699252
18PRPF4B1.93413564
19WNK11.82633453
20MAP3K11.76288791
21ITK1.76025249
22TEC1.72626736
23IRAK41.72595331
24TAOK31.72204512
25HIPK21.68163143
26BTK1.64504370
27ERN11.62800574
28PRKG21.55057234
29IRAK31.54958156
30SGK21.54871255
31CSK1.51744011
32MAP3K71.50329131
33INSRR1.47106647
34NTRK21.46395332
35MAP3K141.46251698
36IRAK21.43419910
37PIK3CA1.40934431
38FGR1.37533865
39TESK21.36151205
40FGFR31.35139496
41TBK11.34556279
42CDK81.30197520
43IRAK11.28881956
44TNK21.26305152
45MAP3K51.25074561
46PRKCH1.21991266
47MAP3K41.19511553
48SMG11.18027158
49AKT31.17384811
50BLK1.15806270
51BMPR1B1.14781643
52PNCK1.14286406
53ERBB31.12828559
54TRIB31.10940494
55KSR21.10914548
56SRPK11.09536139
57BMPR21.09403065
58MAP3K101.07479219
59MARK31.04607566
60CDC42BPA1.03151375
61ZAP701.02988712
62SIK31.01855117
63PASK0.95803472
64PTK60.93694214
65JAK10.91196412
66PIM10.91074142
67STK100.89129684
68MAP3K20.88936764
69TSSK60.87369281
70CAMK1G0.87163243
71MARK20.86938019
72CDK40.86613088
73RPS6KB10.85816322
74SGK4940.85698166
75SGK2230.85698166
76CDK60.85388139
77TIE10.84288129
78IKBKE0.84164705
79MELK0.83813705
80MAP3K80.83464907
81EEF2K0.83156366
82SYK0.81270939
83EPHB10.81138204
84SIK10.81024897
85GRK60.80978450
86PDK10.77750079
87FGFR40.76721455
88TNIK0.76481838
89DYRK1A0.72942088
90MAPK70.70749906
91JAK30.70391167
92ICK0.68757600
93NLK0.68704455
94MKNK20.68058109
95MAPK80.67066219
96STK30.66334714
97MTOR0.66206587
98TYK20.66003570
99HCK0.64407356
100CSF1R0.63914855
101MARK10.63893720
102MAPK130.63346537
103LYN0.62889431
104CDK30.61544039
105JAK20.60412977
106MOS0.60291598
107PRKD20.59659052
108MATK0.59057107
109LCK0.58538412
110RAF10.58384173
111UHMK10.56916127
112GSK3B0.55777992
113MAPK140.53930313
114ALK0.52293188
115MAP3K60.50464584
116MAPK30.49921041
117PRKD30.47269363
118FGFR10.46011155
119KIT0.45578059
120MAP2K20.45136300
121PKN20.45111422
122MAP3K130.44860511
123PDPK10.44724519
124ATM0.44547306
125PRKCB0.44391837
126MAPK110.44100313
127IKBKB0.43834982
128FES0.43797358
129TGFBR20.42661192
130PLK30.42355065
131ATR0.41526214
132MAP2K60.41505372
133BMX0.41098052
134FGFR20.40889742
135TTN0.40833771
136YES10.40781169
137SGK10.40158045
138SCYL20.36199002
139KSR10.35660605
140ABL20.33081210
141LRRK20.31991447
142PAK40.31885967
143CLK10.31598613
144CHUK0.31364847
145RET0.28498389
146NME20.28443783
147RPS6KA40.28220969
148MAPKAPK20.28183076
149ARAF0.24832926
150PRKCQ0.24380329

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.96814061
2Leishmaniasis_Homo sapiens_hsa051402.19830099
3Olfactory transduction_Homo sapiens_hsa047402.08869592
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08626848
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95273558
6NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80663540
7Circadian entrainment_Homo sapiens_hsa047131.80066755
8Insulin secretion_Homo sapiens_hsa049111.75186153
9B cell receptor signaling pathway_Homo sapiens_hsa046621.74648384
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.72626743
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71997280
12Nicotine addiction_Homo sapiens_hsa050331.71403254
13TNF signaling pathway_Homo sapiens_hsa046681.65917145
14T cell receptor signaling pathway_Homo sapiens_hsa046601.64095668
15Taste transduction_Homo sapiens_hsa047421.60651963
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59717833
17Morphine addiction_Homo sapiens_hsa050321.58878451
18Type II diabetes mellitus_Homo sapiens_hsa049301.57288529
19Graft-versus-host disease_Homo sapiens_hsa053321.55499857
20Allograft rejection_Homo sapiens_hsa053301.55159629
21Amphetamine addiction_Homo sapiens_hsa050311.54889934
22Tuberculosis_Homo sapiens_hsa051521.54316353
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53847573
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52269340
25Viral myocarditis_Homo sapiens_hsa054161.51112205
26Autoimmune thyroid disease_Homo sapiens_hsa053201.49455711
27Long-term potentiation_Homo sapiens_hsa047201.49098333
28Dorso-ventral axis formation_Homo sapiens_hsa043201.48693835
29Staphylococcus aureus infection_Homo sapiens_hsa051501.46991313
30Legionellosis_Homo sapiens_hsa051341.43466177
31Toxoplasmosis_Homo sapiens_hsa051451.41864162
32Epstein-Barr virus infection_Homo sapiens_hsa051691.41318258
33Lysine degradation_Homo sapiens_hsa003101.39081085
34Acute myeloid leukemia_Homo sapiens_hsa052211.37149633
35Glutamatergic synapse_Homo sapiens_hsa047241.32998512
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32448013
37Cocaine addiction_Homo sapiens_hsa050301.31044997
38Malaria_Homo sapiens_hsa051441.29251714
39Long-term depression_Homo sapiens_hsa047301.28189858
40Colorectal cancer_Homo sapiens_hsa052101.25934293
41mRNA surveillance pathway_Homo sapiens_hsa030151.25791356
42Salivary secretion_Homo sapiens_hsa049701.24061970
43Apoptosis_Homo sapiens_hsa042101.21705039
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.21625612
45Notch signaling pathway_Homo sapiens_hsa043301.19389279
46Cholinergic synapse_Homo sapiens_hsa047251.19046282
47Type I diabetes mellitus_Homo sapiens_hsa049401.18505516
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16809478
49Shigellosis_Homo sapiens_hsa051311.14664725
50Circadian rhythm_Homo sapiens_hsa047101.14145613
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13997240
52Dopaminergic synapse_Homo sapiens_hsa047281.12738163
53Chronic myeloid leukemia_Homo sapiens_hsa052201.11742858
54GABAergic synapse_Homo sapiens_hsa047271.11634072
55Estrogen signaling pathway_Homo sapiens_hsa049151.10680302
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10314027
57Other glycan degradation_Homo sapiens_hsa005111.10069012
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09699953
59Renin secretion_Homo sapiens_hsa049241.09023996
60Phototransduction_Homo sapiens_hsa047441.07381631
61Viral carcinogenesis_Homo sapiens_hsa052031.07076416
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07023321
63Hepatitis C_Homo sapiens_hsa051601.05423163
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04730326
65Measles_Homo sapiens_hsa051621.04636581
66Platelet activation_Homo sapiens_hsa046111.04117666
67VEGF signaling pathway_Homo sapiens_hsa043701.03705825
68Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03190929
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01895618
70Salmonella infection_Homo sapiens_hsa051320.99939708
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97570132
72Prolactin signaling pathway_Homo sapiens_hsa049170.96783625
73Glucagon signaling pathway_Homo sapiens_hsa049220.95866425
74Thyroid cancer_Homo sapiens_hsa052160.95503802
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.94197887
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93681862
77MAPK signaling pathway_Homo sapiens_hsa040100.93190373
78Inositol phosphate metabolism_Homo sapiens_hsa005620.92859378
79Serotonergic synapse_Homo sapiens_hsa047260.89279538
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86565934
81ABC transporters_Homo sapiens_hsa020100.86285495
82Osteoclast differentiation_Homo sapiens_hsa043800.86133077
83cAMP signaling pathway_Homo sapiens_hsa040240.85882375
84FoxO signaling pathway_Homo sapiens_hsa040680.85256995
85mTOR signaling pathway_Homo sapiens_hsa041500.84465577
86Pertussis_Homo sapiens_hsa051330.84411919
87Choline metabolism in cancer_Homo sapiens_hsa052310.83997348
88Wnt signaling pathway_Homo sapiens_hsa043100.83065615
89Gastric acid secretion_Homo sapiens_hsa049710.82205007
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82140170
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81861880
92Amoebiasis_Homo sapiens_hsa051460.79276235
93Renal cell carcinoma_Homo sapiens_hsa052110.79265518
94Spliceosome_Homo sapiens_hsa030400.79163511
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78941353
96Calcium signaling pathway_Homo sapiens_hsa040200.78936297
97Endometrial cancer_Homo sapiens_hsa052130.78297145
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78021523
99Pancreatic secretion_Homo sapiens_hsa049720.77713701
100N-Glycan biosynthesis_Homo sapiens_hsa005100.77597438
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.77118837
102Oxytocin signaling pathway_Homo sapiens_hsa049210.76814508
103ErbB signaling pathway_Homo sapiens_hsa040120.75360071
104Chemokine signaling pathway_Homo sapiens_hsa040620.75065379
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.74914646
106Phagosome_Homo sapiens_hsa041450.74895012
107Antigen processing and presentation_Homo sapiens_hsa046120.74834818
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.74117083
109Influenza A_Homo sapiens_hsa051640.73418586
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.73318428
111Hematopoietic cell lineage_Homo sapiens_hsa046400.73168832
112RNA transport_Homo sapiens_hsa030130.72802541
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72269674
114Prostate cancer_Homo sapiens_hsa052150.72186986
115Bladder cancer_Homo sapiens_hsa052190.70901770
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70566948
117Synaptic vesicle cycle_Homo sapiens_hsa047210.70256910
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69271607
119Non-small cell lung cancer_Homo sapiens_hsa052230.68819099
120MicroRNAs in cancer_Homo sapiens_hsa052060.68707771
121Sphingolipid metabolism_Homo sapiens_hsa006000.68381201
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66973611
123Insulin resistance_Homo sapiens_hsa049310.66901619
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66779723
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.65592202
126GnRH signaling pathway_Homo sapiens_hsa049120.65325239
127Hepatitis B_Homo sapiens_hsa051610.64397860
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63765207
129Pancreatic cancer_Homo sapiens_hsa052120.63222536
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63085274
131Herpes simplex infection_Homo sapiens_hsa051680.62597225
132HTLV-I infection_Homo sapiens_hsa051660.62307390
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.61751608
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61251139
135African trypanosomiasis_Homo sapiens_hsa051430.61167659
136HIF-1 signaling pathway_Homo sapiens_hsa040660.60941510
137Thyroid hormone synthesis_Homo sapiens_hsa049180.60894406
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.60717369
139Pentose phosphate pathway_Homo sapiens_hsa000300.60226787
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.58641877
141Small cell lung cancer_Homo sapiens_hsa052220.57901865
142Endocytosis_Homo sapiens_hsa041440.57631042
143Melanogenesis_Homo sapiens_hsa049160.57627273
144Insulin signaling pathway_Homo sapiens_hsa049100.56988662
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54919495
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54410245
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54350040
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54171124
149Vitamin B6 metabolism_Homo sapiens_hsa007500.53836281
150Basal cell carcinoma_Homo sapiens_hsa052170.53006595
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52988118
152Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51692708
153RNA polymerase_Homo sapiens_hsa030200.50765242
154Rheumatoid arthritis_Homo sapiens_hsa053230.50746128
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49415091
156AMPK signaling pathway_Homo sapiens_hsa041520.48244819
157Cell cycle_Homo sapiens_hsa041100.47213051

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