TRIM39-RPP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring TRIM39 (tripartite motif-containing 39) and RPP21 (ribonuclease P/MRP 21kDa subunit) genes on chromosome 6. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.97276568
2negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.24287249
3regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.95248844
4L-serine metabolic process (GO:0006563)4.81822868
5cullin deneddylation (GO:0010388)4.70423849
6negative regulation of ligase activity (GO:0051352)4.70259465
7negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.70259465
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.69978413
9establishment of integrated proviral latency (GO:0075713)4.66446387
10anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.64487078
11protein deneddylation (GO:0000338)4.55679493
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.52710352
13mitotic metaphase plate congression (GO:0007080)4.34671830
14protein localization to kinetochore (GO:0034501)4.33070139
15DNA damage response, detection of DNA damage (GO:0042769)4.31449674
16telomere maintenance via semi-conservative replication (GO:0032201)4.24617948
17DNA strand elongation involved in DNA replication (GO:0006271)4.18344135
18regulation of cellular amino acid metabolic process (GO:0006521)4.17142286
19DNA ligation (GO:0006266)4.08439236
20protein localization to chromosome, centromeric region (GO:0071459)4.04719565
21positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.02936196
22establishment of viral latency (GO:0019043)4.01398538
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.01359809
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.01359809
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.01359809
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.00724822
27chaperone-mediated protein transport (GO:0072321)3.96601676
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.95552082
29signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.95552082
30regulation of mitochondrial translation (GO:0070129)3.95151356
31DNA strand elongation (GO:0022616)3.94015714
32spindle checkpoint (GO:0031577)3.89006758
33CENP-A containing nucleosome assembly (GO:0034080)3.85476324
34chromatin remodeling at centromere (GO:0031055)3.84977388
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.84903827
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.84903827
37positive regulation of ligase activity (GO:0051351)3.83086547
38signal transduction involved in cell cycle checkpoint (GO:0072395)3.81072749
39peptidyl-histidine modification (GO:0018202)3.79126955
40regulation of ubiquitin-protein transferase activity (GO:0051438)3.78450289
41lactate metabolic process (GO:0006089)3.73149150
42attachment of spindle microtubules to kinetochore (GO:0008608)3.63804495
43regulation of ligase activity (GO:0051340)3.62713013
44negative regulation of mitotic sister chromatid segregation (GO:0033048)3.60510199
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.60510199
46negative regulation of sister chromatid segregation (GO:0033046)3.60510199
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.60510199
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.60510199
49negative regulation of chromosome segregation (GO:0051985)3.57277318
50metaphase plate congression (GO:0051310)3.56037082
51telomere maintenance via recombination (GO:0000722)3.53406373
52spindle assembly checkpoint (GO:0071173)3.53275633
53purine nucleobase biosynthetic process (GO:0009113)3.48653562
54serine family amino acid biosynthetic process (GO:0009070)3.47455286
55mitotic spindle checkpoint (GO:0071174)3.46536454
56mitotic spindle assembly checkpoint (GO:0007094)3.45966827
57mitotic sister chromatid segregation (GO:0000070)3.44652048
58transcription-coupled nucleotide-excision repair (GO:0006283)3.38117591
59ribosome assembly (GO:0042255)3.34878231
60mitotic recombination (GO:0006312)3.34399744
61oxidative phosphorylation (GO:0006119)3.32068236
62IMP biosynthetic process (GO:0006188)3.28442435
63regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25912610
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25912610
65negative regulation of protein ubiquitination (GO:0031397)3.24009759
66pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22563574
67iron-sulfur cluster assembly (GO:0016226)3.21751592
68metallo-sulfur cluster assembly (GO:0031163)3.21751592
69DNA strand renaturation (GO:0000733)3.21321043
70kinetochore assembly (GO:0051382)3.19731806
71negative regulation of mitosis (GO:0045839)3.18458971
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.18001114
73regulation of sister chromatid segregation (GO:0033045)3.16190617
74regulation of mitotic sister chromatid separation (GO:0010965)3.16190617
75regulation of mitotic sister chromatid segregation (GO:0033047)3.16190617
76negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.06284080
77histone exchange (GO:0043486)3.06116117
78DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.06084186
79mitochondrial respiratory chain complex assembly (GO:0033108)3.04999665
80GTP biosynthetic process (GO:0006183)3.04464210
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.04288158
82CTP biosynthetic process (GO:0006241)3.04198154
83CTP metabolic process (GO:0046036)3.04198154
84regulation of cellular amine metabolic process (GO:0033238)3.04155917
85telomere maintenance via telomere lengthening (GO:0010833)3.03878509
86DNA replication checkpoint (GO:0000076)3.03294715
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02786400
88sister chromatid segregation (GO:0000819)3.01918718
89nucleobase biosynthetic process (GO:0046112)3.01422902
90IMP metabolic process (GO:0046040)3.00200629
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98940877
92regulation of mitotic spindle checkpoint (GO:1903504)2.98940877
93tRNA aminoacylation (GO:0043039)2.98513458
94amino acid activation (GO:0043038)2.98513458
95base-excision repair (GO:0006284)2.98084199
96tRNA aminoacylation for protein translation (GO:0006418)2.97429275
97kinetochore organization (GO:0051383)2.96947397
98DNA double-strand break processing (GO:0000729)2.95021274
99regulation of chromosome segregation (GO:0051983)2.94781467
100protein heterotetramerization (GO:0051290)2.94025051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.51130223
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.43668480
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.95729428
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75748145
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.66108072
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.64724338
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.63230841
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.63020451
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53501404
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.53198006
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.17080612
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99678048
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.95869310
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81474583
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80351460
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80319364
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79004042
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75108047
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58357620
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52380469
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48781651
22DCP1A_22483619_ChIP-Seq_HELA_Human2.48514921
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.42305672
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41916134
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40825051
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39623627
27ELK1_19687146_ChIP-ChIP_HELA_Human2.36316302
28VDR_23849224_ChIP-Seq_CD4+_Human2.32592759
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32004855
30AR_21909140_ChIP-Seq_LNCAP_Human2.28706548
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27625437
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.16697760
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13350248
34FOXP3_21729870_ChIP-Seq_TREG_Human2.11613237
35GABP_19822575_ChIP-Seq_HepG2_Human2.08268224
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06640882
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01111586
38TTF2_22483619_ChIP-Seq_HELA_Human1.89612722
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86962219
40XRN2_22483619_ChIP-Seq_HELA_Human1.82805480
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78556700
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70841515
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70245052
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68291313
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64165737
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62481534
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62022712
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53605846
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.53063964
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49807619
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49403456
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49337212
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.41907749
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39031964
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38982968
56MYC_18940864_ChIP-ChIP_HL60_Human1.37345737
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36470767
58VDR_22108803_ChIP-Seq_LS180_Human1.35231266
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23737214
60KDM5A_27292631_Chip-Seq_BREAST_Human1.19975113
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.18906784
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18014642
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.16136906
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16027823
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.11960367
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10320745
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07904935
68ZNF274_21170338_ChIP-Seq_K562_Hela1.05483057
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02468050
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98137969
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97612988
72IGF1R_20145208_ChIP-Seq_DFB_Human0.95588949
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95578967
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95298683
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94590896
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94196406
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92652821
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90732723
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89850324
80SOX2_16153702_ChIP-ChIP_HESCs_Human0.87968430
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.87497296
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86988976
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.85563064
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85087344
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.84106468
86EWS_26573619_Chip-Seq_HEK293_Human0.82963425
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81959908
88TFEB_21752829_ChIP-Seq_HELA_Human0.81428908
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79748600
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77692108
91CIITA_25753668_ChIP-Seq_RAJI_Human0.76664653
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74806027
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73485113
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72110494
95FUS_26573619_Chip-Seq_HEK293_Human0.71352798
96EOMES_21245162_ChIP-Seq_HESCs_Human0.70550238
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70301466
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.68934000
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68667617
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66581273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.52441719
2MP0008789_abnormal_olfactory_epithelium4.31468240
3MP0003693_abnormal_embryo_hatching4.08973108
4MP0002102_abnormal_ear_morphology4.05651441
5MP0008058_abnormal_DNA_repair3.83864442
6MP0009697_abnormal_copulation3.66537003
7MP0003111_abnormal_nucleus_morphology3.59176081
8MP0003077_abnormal_cell_cycle3.11937812
9MP0004957_abnormal_blastocyst_morpholog2.98108462
10MP0005499_abnormal_olfactory_system2.88489088
11MP0005394_taste/olfaction_phenotype2.88489088
12MP0008932_abnormal_embryonic_tissue2.75236568
13MP0006054_spinal_hemorrhage2.57231768
14MP0008007_abnormal_cellular_replicative2.40099281
15MP0003283_abnormal_digestive_organ2.37026646
16MP0003186_abnormal_redox_activity2.35036366
17MP0003718_maternal_effect2.32908218
18MP0008877_abnormal_DNA_methylation2.22170857
19MP0004147_increased_porphyrin_level2.10450632
20MP0006035_abnormal_mitochondrial_morpho2.06209727
21MP0006072_abnormal_retinal_apoptosis2.05864166
22MP0003786_premature_aging1.96966943
23MP0005075_abnormal_melanosome_morpholog1.94767899
24MP0006036_abnormal_mitochondrial_physio1.89894867
25MP0000749_muscle_degeneration1.84186287
26MP0001727_abnormal_embryo_implantation1.79664729
27MP0004133_heterotaxia1.69637359
28MP0000372_irregular_coat_pigmentation1.65376634
29MP0010030_abnormal_orbit_morphology1.64953688
30MP0005171_absent_coat_pigmentation1.55256417
31MP0001730_embryonic_growth_arrest1.54754553
32MP0000358_abnormal_cell_content/1.44306502
33MP0002090_abnormal_vision1.39709769
34MP0001529_abnormal_vocalization1.39497651
35MP0003806_abnormal_nucleotide_metabolis1.39486618
36MP0002254_reproductive_system_inflammat1.36620545
37MP0008260_abnormal_autophagy1.35289087
38MP0001984_abnormal_olfaction1.30964912
39MP0003136_yellow_coat_color1.28224754
40MP0005253_abnormal_eye_physiology1.26512803
41MP0006292_abnormal_olfactory_placode1.25569212
42MP0001299_abnormal_eye_distance/1.21224055
43MP0002282_abnormal_trachea_morphology1.19984555
44MP0001293_anophthalmia1.19493592
45MP0001346_abnormal_lacrimal_gland1.18367176
46MP0002822_catalepsy1.16907745
47MP0005645_abnormal_hypothalamus_physiol1.16027244
48MP0003941_abnormal_skin_development1.14527552
49MP0003221_abnormal_cardiomyocyte_apopto1.05972614
50MP0002751_abnormal_autonomic_nervous1.05130896
51MP0000350_abnormal_cell_proliferation1.04435572
52MP0002132_abnormal_respiratory_system1.03111147
53MP0003119_abnormal_digestive_system1.01480394
54MP0001119_abnormal_female_reproductive1.01267367
55MP0002233_abnormal_nose_morphology1.00488422
56MP0002638_abnormal_pupillary_reflex1.00405844
57MP0005380_embryogenesis_phenotype0.98686968
58MP0001672_abnormal_embryogenesis/_devel0.98686968
59MP0002837_dystrophic_cardiac_calcinosis0.96580625
60MP0005646_abnormal_pituitary_gland0.96021542
61MP0002653_abnormal_ependyma_morphology0.94392566
62MP0004858_abnormal_nervous_system0.91367244
63MP0001764_abnormal_homeostasis0.91360991
64MP0002085_abnormal_embryonic_tissue0.90940694
65MP0002080_prenatal_lethality0.90101471
66MP0003880_abnormal_central_pattern0.87992581
67MP0001485_abnormal_pinna_reflex0.86966200
68MP0001697_abnormal_embryo_size0.84486130
69MP0008995_early_reproductive_senescence0.84478962
70MP0005084_abnormal_gallbladder_morpholo0.83122831
71MP0000313_abnormal_cell_death0.81905982
72MP0003878_abnormal_ear_physiology0.80991635
73MP0005377_hearing/vestibular/ear_phenot0.80991635
74MP0003937_abnormal_limbs/digits/tail_de0.80231644
75MP0001661_extended_life_span0.80203119
76MP0000653_abnormal_sex_gland0.76862381
77MP0002938_white_spotting0.75464058
78MP0004215_abnormal_myocardial_fiber0.73745194
79MP0002084_abnormal_developmental_patter0.71912378
80MP0001929_abnormal_gametogenesis0.69796106
81MP0003984_embryonic_growth_retardation0.67472584
82MP0005408_hypopigmentation0.66006261
83MP0001145_abnormal_male_reproductive0.63527258
84MP0001324_abnormal_eye_pigmentation0.63430181
85MP0002111_abnormal_tail_morphology0.61616777
86MP0002088_abnormal_embryonic_growth/wei0.59999598
87MP0005330_cardiomyopathy0.59020220
88MP0005391_vision/eye_phenotype0.58960674
89MP0002295_abnormal_pulmonary_circulatio0.57853588
90MP0005551_abnormal_eye_electrophysiolog0.57526172
91MP0004197_abnormal_fetal_growth/weight/0.57382272
92MP0002019_abnormal_tumor_incidence0.57137570
93MP0001963_abnormal_hearing_physiology0.56533390
94MP0002269_muscular_atrophy0.55620102
95MP0005647_abnormal_sex_gland0.52252846
96MP0000647_abnormal_sebaceous_gland0.51596070
97MP0003121_genomic_imprinting0.51536502
98MP0000631_abnormal_neuroendocrine_gland0.50832594
99MP0001286_abnormal_eye_development0.50793938
100MP0003137_abnormal_impulse_conducting0.50022788

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)4.37729007
2Hepatocellular necrosis (HP:0001404)3.98950759
3Abnormality of glycolysis (HP:0004366)3.89928028
4Microvesicular hepatic steatosis (HP:0001414)3.85713177
5Acute necrotizing encephalopathy (HP:0006965)3.71982869
6Abnormal mitochondria in muscle tissue (HP:0008316)3.59936282
7Mitochondrial inheritance (HP:0001427)3.56733255
8Acute encephalopathy (HP:0006846)3.47180312
9Hepatic necrosis (HP:0002605)3.43041261
10Progressive macrocephaly (HP:0004481)3.15844778
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14975361
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14975361
13Increased CSF lactate (HP:0002490)3.14262408
14Hyperglycinemia (HP:0002154)3.03455592
15Type I transferrin isoform profile (HP:0003642)2.98861303
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93988001
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81684758
18Abnormality of alanine metabolism (HP:0010916)2.81684758
19Hyperalaninemia (HP:0003348)2.81684758
20Abnormality of the labia minora (HP:0012880)2.79482267
21Chromsome breakage (HP:0040012)2.76885958
22Cerebral edema (HP:0002181)2.74465320
23Meckel diverticulum (HP:0002245)2.70796772
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68850666
25Abnormal protein N-linked glycosylation (HP:0012347)2.68850666
26Abnormal protein glycosylation (HP:0012346)2.68850666
27Abnormal glycosylation (HP:0012345)2.68850666
28Hypoplastic pelvis (HP:0008839)2.67259283
29Supernumerary spleens (HP:0009799)2.65761895
30Increased serum lactate (HP:0002151)2.62713756
31Lactic acidosis (HP:0003128)2.61765329
32Abnormality of the ileum (HP:0001549)2.58509096
33Abnormality of chromosome stability (HP:0003220)2.54794489
34Short tibia (HP:0005736)2.51068535
35Increased intramyocellular lipid droplets (HP:0012240)2.50830039
36Reticulocytopenia (HP:0001896)2.49098549
37Duodenal stenosis (HP:0100867)2.46677050
38Small intestinal stenosis (HP:0012848)2.46677050
39Methylmalonic aciduria (HP:0012120)2.44720732
40Respiratory failure (HP:0002878)2.43859082
41Colon cancer (HP:0003003)2.43177182
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.35129310
43CNS demyelination (HP:0007305)2.34781777
44Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28242847
45Abnormality of serine family amino acid metabolism (HP:0010894)2.25451551
46Abnormality of glycine metabolism (HP:0010895)2.25451551
47Exercise intolerance (HP:0003546)2.25002496
48Abnormality of serum amino acid levels (HP:0003112)2.21672381
49Adrenal hypoplasia (HP:0000835)2.21529080
50Preaxial hand polydactyly (HP:0001177)2.17237275
51Cerebral hypomyelination (HP:0006808)2.16981003
52Neoplasm of the adrenal gland (HP:0100631)2.16091103
53Postnatal microcephaly (HP:0005484)2.15678495
54Abnormal lung lobation (HP:0002101)2.15326718
55Abnormality of the preputium (HP:0100587)2.15257155
56Congenital primary aphakia (HP:0007707)2.15120719
57Horseshoe kidney (HP:0000085)2.14093034
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.13573007
59True hermaphroditism (HP:0010459)2.12426873
60Renal Fanconi syndrome (HP:0001994)2.11544467
61Pancreatic fibrosis (HP:0100732)2.10133120
62Abnormality of the duodenum (HP:0002246)2.09250102
63Abnormality of the anterior horn cell (HP:0006802)2.09046994
64Degeneration of anterior horn cells (HP:0002398)2.09046994
653-Methylglutaconic aciduria (HP:0003535)2.08944909
66Medial flaring of the eyebrow (HP:0010747)2.07009837
67Single umbilical artery (HP:0001195)2.06144055
68Abnormality of the fetal cardiovascular system (HP:0010948)2.06144055
69Abnormal umbilical cord blood vessels (HP:0011403)2.06144055
70Emotional lability (HP:0000712)2.05695120
71Increased muscle lipid content (HP:0009058)2.00588252
72Gait imbalance (HP:0002141)2.00034869
73Nephrogenic diabetes insipidus (HP:0009806)1.98889915
74Median cleft lip (HP:0000161)1.98193675
75Abnormality of the umbilical cord (HP:0010881)1.97927864
76Sloping forehead (HP:0000340)1.97559165
77Patent foramen ovale (HP:0001655)1.96195525
78Pancreatic cysts (HP:0001737)1.93594554
79Unsteady gait (HP:0002317)1.92463189
80Absent thumb (HP:0009777)1.91819528
81Hyperglycinuria (HP:0003108)1.91320927
82Severe visual impairment (HP:0001141)1.90652063
83Absent epiphyses (HP:0010577)1.90576507
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90576507
85Morphological abnormality of the inner ear (HP:0011390)1.89552180
86Triphalangeal thumb (HP:0001199)1.89509865
87Occipital encephalocele (HP:0002085)1.88793101
88Absent radius (HP:0003974)1.86486666
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.86445736
90Leukodystrophy (HP:0002415)1.85525606
91Anencephaly (HP:0002323)1.84195308
92Abnormalities of placenta or umbilical cord (HP:0001194)1.83411181
93Abnormal gallbladder physiology (HP:0012438)1.83317174
94Cholecystitis (HP:0001082)1.83317174
95Genital tract atresia (HP:0001827)1.80523312
96Absent forearm bone (HP:0003953)1.80272398
97Aplasia involving forearm bones (HP:0009822)1.80272398
98Sclerocornea (HP:0000647)1.77094644
99Secondary amenorrhea (HP:0000869)1.76229433
100Palpitations (HP:0001962)1.75634014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72485297
2TTK3.41982940
3CDC73.40424771
4VRK23.22406148
5NEK13.15130620
6SRPK13.13137406
7ZAK3.12853205
8BCKDK3.07304328
9TSSK63.00772626
10PBK2.83543455
11PLK32.42392068
12BCR2.09136442
13MST1R2.07053563
14PLK11.97147225
15EIF2AK11.87188413
16BRSK11.86633266
17BRSK21.84205735
18WEE11.79673077
19VRK11.79290471
20CCNB11.76457124
21MAP4K21.60698409
22MST41.58965779
23EIF2AK31.54020508
24STK161.53688652
25NME11.48909613
26NUAK11.40678593
27PLK41.34223646
28MAP2K71.26263614
29LMTK21.25446448
30EPHA41.22801895
31ATR1.20531250
32NME21.19549911
33PLK21.15089557
34CDK81.13563610
35MKNK11.10351619
36TRIM281.10270253
37AURKB1.09141907
38NEK21.05438155
39PAK41.05356939
40STK101.04092826
41KDR1.00876986
42CHEK21.00652189
43CSNK1G30.99978345
44DYRK20.92029740
45CDK90.88065705
46ERBB30.86906453
47DAPK10.82400765
48GRK10.81156759
49CSNK1A1L0.80630371
50CDK70.78894220
51TIE10.77545551
52CSNK1G10.74838846
53AURKA0.74273943
54BRAF0.73071256
55CDK190.72693919
56NEK90.71528954
57MET0.68508042
58EIF2AK20.65255529
59PDK20.64661753
60CSNK1G20.62773172
61MAP3K40.61123309
62WNK30.60181185
63PIM20.55961371
64LIMK10.55291869
65CHEK10.54756098
66PASK0.53517175
67PRKD30.50442927
68ATM0.50342298
69CSNK2A10.48792467
70STK40.48001465
71BMPR1B0.46621935
72TNIK0.45851707
73MAP3K120.45462912
74MAP3K80.44302845
75DYRK30.42774168
76FER0.41816354
77PHKG20.40298984
78PHKG10.40298984
79UHMK10.38832523
80INSRR0.38131424
81NTRK20.37421508
82TESK10.36768488
83PRKCI0.36313708
84CDK140.34962440
85RPS6KA40.34442717
86TESK20.33667971
87CDK10.33413262
88CSNK2A20.33322577
89TAF10.32418680
90ERBB40.31897042
91FLT30.31310714
92ALK0.30801514
93EPHB10.30663937
94PAK10.30011604
95ADRBK20.29433581
96CDK30.28851509
97CDK20.28321658
98CDK180.28191691
99CDK11A0.27650258
100TGFBR10.26551590

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.07606386
2Mismatch repair_Homo sapiens_hsa034303.61916841
3DNA replication_Homo sapiens_hsa030303.59620692
4Homologous recombination_Homo sapiens_hsa034402.63420442
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61491175
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42792198
7Base excision repair_Homo sapiens_hsa034102.40709307
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40240405
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.28663201
10RNA polymerase_Homo sapiens_hsa030202.25666089
11Non-homologous end-joining_Homo sapiens_hsa034502.12573689
12Propanoate metabolism_Homo sapiens_hsa006402.11240476
13Fanconi anemia pathway_Homo sapiens_hsa034602.08402818
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.06587215
15Cysteine and methionine metabolism_Homo sapiens_hsa002702.04688081
16Nucleotide excision repair_Homo sapiens_hsa034202.02343848
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92378032
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87891355
19Biosynthesis of amino acids_Homo sapiens_hsa012301.84855626
20RNA transport_Homo sapiens_hsa030131.83256929
21Parkinsons disease_Homo sapiens_hsa050121.82530624
22Pyruvate metabolism_Homo sapiens_hsa006201.82232722
23Oxidative phosphorylation_Homo sapiens_hsa001901.78867499
24Spliceosome_Homo sapiens_hsa030401.77348934
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75693108
26Pyrimidine metabolism_Homo sapiens_hsa002401.74660696
27Cell cycle_Homo sapiens_hsa041101.62412993
28Carbon metabolism_Homo sapiens_hsa012001.57893357
29Protein export_Homo sapiens_hsa030601.57393707
30One carbon pool by folate_Homo sapiens_hsa006701.54417718
31Ribosome_Homo sapiens_hsa030101.46267313
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44641288
33Glutathione metabolism_Homo sapiens_hsa004801.44450656
34Steroid biosynthesis_Homo sapiens_hsa001001.44277000
35Sulfur relay system_Homo sapiens_hsa041221.43802830
36Huntingtons disease_Homo sapiens_hsa050161.37991633
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36594994
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32169938
39RNA degradation_Homo sapiens_hsa030181.31045682
40Basal transcription factors_Homo sapiens_hsa030221.26051068
41Fatty acid elongation_Homo sapiens_hsa000621.21689207
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.20435969
43Purine metabolism_Homo sapiens_hsa002301.19195052
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12247042
45Pentose phosphate pathway_Homo sapiens_hsa000301.04712073
46Vitamin B6 metabolism_Homo sapiens_hsa007501.04279799
47Alzheimers disease_Homo sapiens_hsa050100.98658484
48Oocyte meiosis_Homo sapiens_hsa041140.95121011
49Butanoate metabolism_Homo sapiens_hsa006500.93963191
50Folate biosynthesis_Homo sapiens_hsa007900.89511200
51Arginine and proline metabolism_Homo sapiens_hsa003300.88654580
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85997332
53Peroxisome_Homo sapiens_hsa041460.84275871
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84073075
55Nitrogen metabolism_Homo sapiens_hsa009100.83415487
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78551559
57p53 signaling pathway_Homo sapiens_hsa041150.76428384
58Metabolic pathways_Homo sapiens_hsa011000.73785007
59beta-Alanine metabolism_Homo sapiens_hsa004100.67958245
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65517989
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59144940
62Fatty acid degradation_Homo sapiens_hsa000710.57809222
63Fructose and mannose metabolism_Homo sapiens_hsa000510.55327650
64mRNA surveillance pathway_Homo sapiens_hsa030150.55146812
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54243143
66N-Glycan biosynthesis_Homo sapiens_hsa005100.52813702
67Selenocompound metabolism_Homo sapiens_hsa004500.52714029
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49990530
69Epstein-Barr virus infection_Homo sapiens_hsa051690.48303043
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46266810
71Sulfur metabolism_Homo sapiens_hsa009200.43890448
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43566322
73Basal cell carcinoma_Homo sapiens_hsa052170.43208348
74Fatty acid metabolism_Homo sapiens_hsa012120.43197926
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42986004
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.40622830
77Galactose metabolism_Homo sapiens_hsa000520.38275838
78TGF-beta signaling pathway_Homo sapiens_hsa043500.35845906
79Cardiac muscle contraction_Homo sapiens_hsa042600.32594760
80Tyrosine metabolism_Homo sapiens_hsa003500.31658487
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31517025
82Tryptophan metabolism_Homo sapiens_hsa003800.30506936
83Regulation of autophagy_Homo sapiens_hsa041400.30208816
84Legionellosis_Homo sapiens_hsa051340.29654319
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29006502
86Phenylalanine metabolism_Homo sapiens_hsa003600.28935756
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26179475
88Phototransduction_Homo sapiens_hsa047440.25183962
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.22763193
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21692687
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21509705
92Arginine biosynthesis_Homo sapiens_hsa002200.20901901
93Hedgehog signaling pathway_Homo sapiens_hsa043400.18857702
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17945747
95Vitamin digestion and absorption_Homo sapiens_hsa049770.17342448
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17101834
97Fat digestion and absorption_Homo sapiens_hsa049750.16389169
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15782626
99Vibrio cholerae infection_Homo sapiens_hsa051100.15432477
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14749694

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